Class ID,Preferred Label,Synonyms,Definitions,Obsolete,CUI,Semantic Types,Parents,alternative term,axiom_lost_from_external_ontology,BFO CLIF specification label,BFO OWL specification label,binds molecular entity,curator note,database_cross_reference,definition,definition source,depicted_by,derives from organ,derives from/develops from,dubious_for_taxon,editor note,editor preferred term,elucidation,example of usage,external_definition,fma_set_term,has amino acid position,has amino acid residue,has associated axiom(fol),has associated axiom(nl),has associated disease from DISEASES,has associated disease with at least some evidence from DISEASES,has associated disease with at least weak evidence from DISEASES,has associated disease with strong evidence from DISEASES,has associated gene from DISEASE,has associated gene with at least some evidence from DISEASE,has associated gene with at least weak evidence from DISEASE,has associated gene with strong evidence from DISEASE,has associated tissue,has curation status,has functional parent,has gating mechanism,has gene template,has quality,has quaternary organization,has role,has target development level,has topology,has_alternative_id,has_broad_synonym,has_exact_synonym,has_narrow_synonym,has_obo_namespace,has_related_synonym,has_relational_adjective,homology_notes,http://data.bioontology.org/metadata/prefixIRI,http://purl.obolibrary.org/obo/created_by,http://purl.obolibrary.org/obo/creation_date,http://purl.obolibrary.org/obo/hasAlternativeId,http://purl.obolibrary.org/obo/hasDbXref,http://purl.obolibrary.org/obo/hasExactSynonym,http://purl.obolibrary.org/obo/hasNarrowSynonym,http://purl.obolibrary.org/obo/hasOBONamespace,http://purl.obolibrary.org/obo/hasRelatedSynonym,http://purl.obolibrary.org/obo/id,http://purl.obolibrary.org/obo/inSubset,http://purl.org/dc/elements/1.1/contributor,http://purl.org/dc/elements/1.1/date,http://purl.org/dc/elements/1.1/description,http://purl.org/dc/elements/1.1/license,http://www.drugtargetontology.org/dto/definition,http://www.drugtargetontology.org/dto/entrez_xref,http://www.drugtargetontology.org/dto/geneSymbol,http://www.drugtargetontology.org/dto/geneSynonym,http://www.drugtargetontology.org/dto/lincs_id,http://www.drugtargetontology.org/dto/uniprot_xref,http://www.geneontology.org/formats/oboInOwl#created_by,http://www.geneontology.org/formats/oboInOwl#creation_date,http://www.geneontology.org/formats/oboInOwl#id,http://www.geneontology.org/formats/oboInOwl#is_class_level,http://www.geneontology.org/formats/oboInOwl#is_metadata_tag,http://www.w3.org/2000/01/rdf-schema#comment,http://www.w3.org/2000/01/rdf-schema#isDefinedBy,http://www.w3.org/2000/01/rdf-schema#label,http://www.w3.org/2002/07/owl#deprecated,http://www.w3.org/2004/02/skos/core#notation,http://xmlns.com/foaf/0.1/page,imported from,in_subset,is associated tissue of,is conjugate acid of,is conjugate base of,is enantiomer of,is expressed in tissue with at least some evidence from TISSUES,is expressed in tissue with at least weak evidence from TISSUES,is expressed in tissue with strong evidence from TISSUES,is expression location of gene with at least some evidence from TISSUES,is expression location of gene with at least weak evidence from TISSUES,is expression location of gene with strong evidence from TISSUES,is gene template of,is mutated form of,is part of,is target development level of,is tautomer of,is transported by,logical macro assertion on an object property,map to pfam domain,part of,related to,shorthand,taxon_notes,temporal interpretation,transports molecular entity
http://www.drugtargetontology.org/dto/DTO_62000173,"[""MET448 in SYK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000173,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET448 in SYK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100507,"[""Serine/threonine-protein kinase 40""]",,"A serine/threonine-protein kinase 40 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N2I9] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300229,,,,,,,,"A serine/threonine-protein kinase 40 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N2I9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100507,,,,https://pharos.nih.gov/idg/targets/Q8N2I9,,,,,,,,,,,,,STK40,SGK495|SHIK,,Q8N2I9,,,,,,,,Serine/threonine-protein kinase 40,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100465,"[""Opsin-3""]",,"An encephalopsin that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H1Y3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"An encephalopsin that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H1Y3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100465,,,,https://pharos.nih.gov/idg/targets/Q9H1Y3,,,,,,,,,,,,,OPN3,ECPN,,Q9H1Y3,,,,,,,,Opsin-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10017,"[""multiple endocrine neoplasia type 1""]",,"An autosomal dominant disease that has_material_basis_in a mutation in the MEN1 tumor suppressor gene and is characterized by over active endocrine glands frequently involving tumors of the parathyroid glands, the pituitary gland, and the pancreas.",false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,"An autosomal dominant disease that has_material_basis_in a mutation in the MEN1 tumor suppressor gene and is characterized by over active endocrine glands frequently involving tumors of the parathyroid glands, the pituitary gland, and the pancreas.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10017,,,,ICD10CM:E31.21|SNOMEDCT_US_2016_03_01:30664006|MESH:D018761|UMLS_CUI:C0025267|OMIM:131100|SNOMEDCT_US_2016_03_01:190566000|NCI:C3225|ICD9CM:258.01|ORDO:652,Wermer's syndrome|multiple endocrine neoplasia type 1|MEN type I|Wermer syndrome,,disease_ontology,,DOID:10017,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,multiple endocrine neoplasia type 1,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10016,"[""multiple endocrine neoplasia type 2B""]",,"An autosomal dominant disease characterized by medullary thyroid carcinoma, pheochromocytoma, multiple mucosal neuromas and intestinal ganglioneuromas, and often a marfanoid habitus and other skeletal abnormalities.",false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,"An autosomal dominant disease characterized by medullary thyroid carcinoma, pheochromocytoma, multiple mucosal neuromas and intestinal ganglioneuromas, and often a marfanoid habitus and other skeletal abnormalities.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10016,,,,OMIM:162300|NCI:C3227|ICD9CM:258.03|SNOMEDCT_US_2016_03_01:61530001|ICD10CM:E31.23|UMLS_CUI:C0025269|MESH:D018814|ORDO:247709,"Wagenmann-Froboese syndrome|multiple endocrine neoplasia type 2b|Multiple endocrine neoplasia, type 3|mucosal neuroma syndrome|MEN2B|MEN type IIB",,disease_ontology,,DOID:10016,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,multiple endocrine neoplasia type 2B,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02302004,"[""5-HT5 receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300017,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02302004,,,,,,,,,,,,,,,,,,,,,,,,,,,,5-HT5 receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300124,"[""RIPK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300107,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300124,,,,,,,,,,,,,,,,,,,,,,,,,,,,RIPK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100816,"[""Vasopressin v1b receptor""]",,"A vasopressin V1b receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47901] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A vasopressin V1b receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47901] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100816,,,,https://pharos.nih.gov/idg/targets/P47901,,,,,,,,,,,,,AVPR1B,AVPR3|VPR3,,P47901,,,,,,,,Vasopressin v1b receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100345,"[""Serine/threonine-protein kinase mtor""]",,"serine/threonine-protein kinase mtor (MTOR)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase mTOR that is encoded in the genome of human. [PRO:CL, UniProtKB:P42345] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391035,,,,,,,,"serine/threonine-protein kinase mtor (MTOR)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase mTOR that is encoded in the genome of human. [PRO:CL, UniProtKB:P42345] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100345,,,,https://pharos.nih.gov/idg/targets/P42345,,,,,,,,,,,,,MTOR,FRAP|FRAP1|FRAP2|RAFT1|RAPT1,,P42345,,,,,,,,Serine/threonine-protein kinase mtor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3007,"[""breast ductal carcinoma""]",,A breast carcinoma that derives_from the lining of milk ducts.,false,,,http://purl.obolibrary.org/obo/DOID_3459,,,,,,,,A breast carcinoma that derives_from the lining of milk ducts.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3007,,,,UMLS_CUI:C1176475|MESH:D044584|SNOMEDCT_US_2016_03_01:82711006,"duct carcinoma, NOS",,disease_ontology,,DOID:3007,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,breast ductal carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13096,"[""Sneddon syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0050828,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13096,,,,SNOMEDCT_US_2016_03_01:238776001|OMIM:182410|UMLS_CUI:C0282492|MESH:D018860,Idiopathic livedo reticularis with systemic involvement (disorder),,disease_ontology,,DOID:13096,,,,,,,,,,,,,,,,,,,Sneddon syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13099,"[""Moyamoya disease""]",,A cerebral arterial disease characterized by constriction of certain arteries at the base of the brain. Blood flow is blocked by the constriction and also by blood clots.,false,,,http://purl.obolibrary.org/obo/DOID_3527,,,,,,,,A cerebral arterial disease characterized by constriction of certain arteries at the base of the brain. Blood flow is blocked by the constriction and also by blood clots.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13099,,,,SNOMEDCT_US_2016_03_01:89142007|ORDO:2573|NCI:C84895|OMIM:608796|SNOMEDCT_US_2016_03_01:69116000|OMIM:614042|ORDO:401945|ORDO:280679|ICD9CM:437.5|OMIM:252350|ICD10CM:I67.5|OMIM:615750|OMIM:300845|MESH:D009072|OMIM:607151|UMLS_CUI:C0026654,progressive intracranial arterial occlusion,,disease_ontology,,DOID:13099,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,Moyamoya disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100110,"[""Frizzled-8""]",,"A frizzled-8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H461] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300043,,,,,,,,"A frizzled-8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H461] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100110,,,,https://pharos.nih.gov/idg/targets/Q9H461,,,,,,,,,,,,,FZD8,,,Q9H461,,,,,,,,Frizzled-8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100128,"[""Protein gpr107""]",,"A protein GPR107 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5VW38] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300051,,,,,,,,"A protein GPR107 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5VW38] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100128,,,,https://pharos.nih.gov/idg/targets/Q5VW38,,,,,,,,,,,,,GPR107,KIAA1624|LUSTR1,,Q5VW38,,,,,,,,Protein gpr107,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001054,"[""pheochromocytoma cell""]",,"Pheochromocytoma is a rare tumor that arises from tissue in the adrenal gland. The tumor increases production of adrenaline and noradrenaline, which raises blood pressure and heart rate.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000592,,,,,,,,"Pheochromocytoma is a rare tumor that arises from tissue in the adrenal gland. The tumor increases production of adrenaline and noradrenaline, which raises blood pressure and heart rate.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001054,,,,,,,BrendaTissueOBO,,BTO:0001054,,,,,,,,,,,,,,,,,,,pheochromocytoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13543,"[""hyperparathyroidism""]",,"A parathyroid gland disease characterized by an overactivity of the parathyroid glands, leading to an excess of parathyroid hormone in the body.",false,,,http://purl.obolibrary.org/obo/DOID_11201,,,,,,,,"A parathyroid gland disease characterized by an overactivity of the parathyroid glands, leading to an excess of parathyroid hormone in the body.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13543,,,,ICD9CM:252.00|OMIM:145001|OMIM:610071|SNOMEDCT_US_2016_03_01:190451000|OMIM:145000|MESH:D006961|SNOMEDCT_US_2016_03_01:154696001|ORDO:99879|ICD9CM:252.0|SNOMEDCT_US_2016_03_01:66999008|NCI:C48259|ICD10CM:E21.3|UMLS_CUI:C0020502,,,disease_ontology,,DOID:13543,,,,,,,,,,,,,,,,,Xref MGI.,,hyperparathyroidism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13544,"[""low tension glaucoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1067,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13544,,,,UMLS_CUI:C0152136|SNOMEDCT_US_2016_03_01:193567005|SNOMEDCT_US_2016_03_01:50485007|SNOMEDCT_US_2016_03_01:155124000|ICD10CM:H40.12|MESH:D057066|ICD9CM:365.12,Normal tension glaucoma,,disease_ontology,,DOID:13544,,,,,,,,,,,,,,,,,,,low tension glaucoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000062,"[""LEU172 in S6K1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000062,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU172 in S6K1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300313,"[""ROCK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300145,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300313,,,,,,,,,,,,,,,,,,,,,,,,,,,,ROCK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200592,"[""OR4K3 gene""]",,"An olfactory receptor 4K3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R72] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4K3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R72] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200592,,,,,,,,,,,,,,,,283617,OR4K3,OR4K3P,,,,,,,,,,OR4K3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001421,"[""uterine cervix""]",,A constricted portion of an organ or part; especially: the narrow outer end of the uterus.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,,A constricted portion of an organ or part; especially: the narrow outer end of the uterus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001421,,,,,,,BrendaTissueOBO,cervix|neck of uterus|cervix of uterus,BTO:0001421,,,,,,,,,,,,,,,,,,,uterine cervix,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2462,"[""retinal vascular disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5679|http://purl.obolibrary.org/obo/DOID_178,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2462,,,,NCI:C35170|SNOMEDCT_US_2016_03_01:57534004|UMLS_CUI:C0154833,retina circulation disorder,,disease_ontology,,DOID:2462,,,,,,,,,,,,,,,,,,,retinal vascular disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217532,"[""RARA gene""]",,"This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_00217461,,,,,,,,"This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217532,,,,,,,,,,,,,,,,5914,RARA,NR1B1,,,,,,,,,,RARA gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1920,"[""hyperuricemia""]",,An acquired metabolic disease that has_material_basis_in an abnormally high level of uric acid in the blood.,false,,,http://purl.obolibrary.org/obo/DOID_0060158,,,,,,,,An acquired metabolic disease that has_material_basis_in an abnormally high level of uric acid in the blood.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1920,,,,SNOMEDCT_US_2016_03_01:166733000|NCI:C3961|SNOMEDCT_US_2016_03_01:271198001|SNOMEDCT_US_2016_03_01:237857006|UMLS_CUI:C0740394|MESH:D033461|SNOMEDCT_US_2016_03_01:144021008|SNOMEDCT_US_2016_03_01:35885006,uricacidemia|(Blood urate raized) or (hyperuricemia),,disease_ontology,,DOID:1920,,,,,,,,,,,,,,,,,,,hyperuricemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200700,"[""OR8I2 gene""]",,"An olfactory receptor 8I2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N0Y5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 8I2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N0Y5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200700,,,,,,,,,,,,,,,,120586,OR8I2,,,,,,,,,,,OR8I2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80338,"[""Calcitonin gene-related peptide 2""]",beta-CGRP|Calcitonin-related polypeptide beta,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16126,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,beta-CGRP|Calcitonin-related polypeptide beta,,,CHEBI:80338,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80338,,,,,Calcitonin gene-related peptide 2,,CHEBI:80338,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100443,"[""Putative olfactory receptor 56b2""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100443,,,,https://pharos.nih.gov/idg/targets/Q8NGI1,,,,,,,,,,,,,OR56B2P,,,Q8NGI1,,,,,,,,Putative olfactory receptor 56b2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100267,"[""Lim domain kinase 1""]",,"A LIM domain kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P53667] |LIM domain kinase 1 (LIMK1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300283,,,,,,,,"A LIM domain kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P53667] |LIM domain kinase 1 (LIMK1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100267,,,,https://pharos.nih.gov/idg/targets/P53667,,,,,,,,,,,,,LIMK1,LIMK,,P53667,,,,,,,,Lim domain kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5419,"[""schizophrenia""]",,A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness.,false,,,http://purl.obolibrary.org/obo/DOID_2468,,,,,,,,A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5419,,,DOID:14734,MESH:D012559|OMIM:608078|ICD9CM:295.8|OMIM:613959|HP:0100753|OMIM:615232|OMIM:603013|OMIM:603175|OMIM:608543|OMIM:603342|OMIM:605419|ICD9CM:295.80|OMIM:600511|OMIM:612361|OMIM:613025|OMIM:604906|OMIM:600850|EFO:0000692|OMIM:613950|OMIM:603176|OMIM:181500|UMLS_CUI:C0029838|OMIM:603206|UMLS_CUI:C0220702|OMIM:181510,schizophrenia-1,,disease_ontology,,DOID:5419,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,schizophrenia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001300,"[""stem""]",,The main trunk of a plant; specifically: a primary plant axis that develops buds and shoots instead of roots.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The main trunk of a plant; specifically: a primary plant axis that develops buds and shoots instead of roots.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001300,,,,,,,BrendaTissueOBO,culm|axis|stalk,BTO:0001300,,,,,,,,,,,,,,,,,,,stem,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000078,"[""microglia""]",,"The small, non-neural, interstitial cells of mesodermal origin that form part of the supporting structure of the central nervous system. They are of various forms and may have slender branched processes. They are migratory and act as phagocytes to waste products of nerve tissue.",false,,,http://purl.obolibrary.org/obo/BTO_0000801|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000524|http://purl.obolibrary.org/obo/BTO_0002606,,,,,,,,"The small, non-neural, interstitial cells of mesodermal origin that form part of the supporting structure of the central nervous system. They are of various forms and may have slender branched processes. They are migratory and act as phagocytes to waste products of nerve tissue.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000078,,,,,,,BrendaTissueOBO,microgliocyte|Hortega cell|microglial cell,BTO:0000078,,,,,,,,,,,,,,,,,,,microglia,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200088,"[""ADGRL4 gene""]",,"An EGF, latrophilin and seven transmembrane domain-containing protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HBW9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400039,,,,,,,,"An EGF, latrophilin and seven transmembrane domain-containing protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HBW9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200088,,,,,,,,,,,,,,,,64123,ELTD1,ETL,,,,,,,,,,ADGRL4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100019,"[""Atypical chemokine receptor 3""]",,"A C-X-C chemokine receptor type 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25106] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300031,,,,,,,,"A C-X-C chemokine receptor type 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25106] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100019,,,,https://pharos.nih.gov/idg/targets/P25106,,,,,,,,,,,,,ACKR3,CMKOR1|CXCR7|GPR159|RDC1,,P25106,,,,,,,,Atypical chemokine receptor 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2151,"[""malignant ovarian surface epithelial-stromal neoplasm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2152,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2151,,,,NCI:C40026|UMLS_CUI:C1518236,,,disease_ontology,,DOID:2151,,,,,,,,,,,,,,,,,,,malignant ovarian surface epithelial-stromal neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200079,"[""CDKL4 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400138,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200079,,,,,,,,,,,,,,,,344387,CDKL4,,,,,,,,,,,CDKL4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8501,"[""fundus dystrophy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5614,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8501,,,,MESH:D058499|UMLS_CUI:C0854723|NCI:C35625|SNOMEDCT_US_2016_03_01:314407005,Retinal Dystrophy,,disease_ontology,,DOID:8501,,,,,,,,,,,,,,,,,,,fundus dystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100217,"[""Calcium/calmodulin-dependent protein kinase type 1g""]",,"A calcium/calmodulin-dependent protein kinase type 1G that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96NX5] |calcium/calmodulin-dependent protein kinase type 1g (CAMK1G)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300171,,,,,,,,"A calcium/calmodulin-dependent protein kinase type 1G that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96NX5] |calcium/calmodulin-dependent protein kinase type 1g (CAMK1G)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100217,,,,https://pharos.nih.gov/idg/targets/Q96NX5,,,,,,,,,,,,,CAMK1G,CLICK3|VWS1,,Q96NX5,,,,,,,,Calcium/calmodulin-dependent protein kinase type 1g,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1342,"[""congenital hypoplastic anemia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_12449,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1342,,,DOID:13639,ICD10CM:D61.01|SNOMEDCT_US_2016_03_01:188588001|UMLS_CUI:C0702159|ICD10CM:D61.0|SNOMEDCT_US_2016_03_01:191235004|SNOMEDCT_US_2016_03_01:154808006|UMLS_CUI:C0949116|SNOMEDCT_US_2016_03_01:191236003|SNOMEDCT_US_2016_03_01:191242004|SNOMEDCT_US_2016_03_01:28975000|MESH:D029502|SNOMEDCT_US_2016_03_01:88854002|ICD9CM:284.0|SNOMEDCT_US_2016_03_01:267523003,congenital aplastic anemia,,disease_ontology,Constitutional aplastic anaemia,DOID:1342,,,,,,,,,,,,,,,,,,,congenital hypoplastic anemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200122,"[""EEF2K gene""]",,"This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400270,,,,,,,,"This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200122,,,,,,,,,,,,,,,,101930123|29904,EEF2K,,,,,,,,,,,EEF2K gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200505,"[""OR1Q1 gene""]",,"An olfactory receptor 1Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15612] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15612] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200505,,,,,,,,,,,,,,,,158131,OR1Q1,OR1Q2|OR1Q3,,,,,,,,,,OR1Q1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_845,"[""cyclothymic disorder""]",,"A bipolar disorder that involves recurrent hypomanic and dysthymic episodes, but no full manic episodes or full major depressive episodes.",false,,,http://purl.obolibrary.org/obo/DOID_3312,,,,,,,,"A bipolar disorder that involves recurrent hypomanic and dysthymic episodes, but no full manic episodes or full major depressive episodes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:845,,,,SNOMEDCT_US_2016_03_01:286737005|ICD9CM:301.10|ICD9CM:301.13|SNOMEDCT_US_2016_03_01:191755004|SNOMEDCT_US_2016_03_01:386798001|SNOMEDCT_US_2016_03_01:191751008|ICD9CM:301.1|ICD10CM:F34.0|SNOMEDCT_US_2016_03_01:14697007|SNOMEDCT_US_2016_03_01:191752001|SNOMEDCT_US_2016_03_01:268756002|SNOMEDCT_US_2016_03_01:192383002|SNOMEDCT_US_2016_03_01:191754000|MESH:D003527|SNOMEDCT_US_2016_03_01:76105009|UMLS_CUI:C0010598,Cycloid personality|Affective personality disorder|Cyclothymia|Cyclothymic personality,,disease_ontology,,DOID:845,,,,,,,,,,,,,,,,,,,cyclothymic disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_848,"[""arthritis""]",,"A bone inflammation disease that involves a response to irritation or injury, characterized by joint pain, swelling, stiffness located_in joint and/or redness located_in skin over the joint.",false,,,http://purl.obolibrary.org/obo/DOID_3342,,,,,,,,"A bone inflammation disease that involves a response to irritation or injury, characterized by joint pain, swelling, stiffness located_in joint and/or redness located_in skin over the joint.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:848,,,,SNOMEDCT_US_2016_03_01:363178003|ICD10CM:M19.90|NCI:C2883|SNOMEDCT_US_2016_03_01:202059001|MESH:D001168|SNOMEDCT_US_2016_03_01:3723001|UMLS_CUI:C0003864|SNOMEDCT_US_2016_03_01:372091005,Inflammatory disorder of joint,,disease_ontology,arthritis,DOID:848,,,,,,,,,,,,,,,,,,,arthritis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_841,"[""extrinsic allergic alveolitis""]",,"An interstitial lung disease involving inflammation of alveoli and smallest airways (bronchioles) of the lung caused by an allergic reaction to inhaled organic dusts containing microorganisms or proteins, and chemicals. Symptoms include chills, cough, fever, malaise, shortness of breath, loss of appetite and weight loss.",false,,,http://purl.obolibrary.org/obo/DOID_3082,,,,,,,,"An interstitial lung disease involving inflammation of alveoli and smallest airways (bronchioles) of the lung caused by an allergic reaction to inhaled organic dusts containing microorganisms or proteins, and chemicals. Symptoms include chills, cough, fever, malaise, shortness of breath, loss of appetite and weight loss.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:841,,,DOID:2707,ICD10CM:J67.9|ICD9CM:495|MESH:D000542|UMLS_CUI:C0002390|ICD9CM:495.9|SNOMEDCT_US_2016_03_01:155581001|SNOMEDCT_US_2016_03_01:195993008|SNOMEDCT_US_2016_03_01:37471005|SNOMEDCT_US_2016_03_01:195994002|SNOMEDCT_US_2016_03_01:266399001|NCI:C34369,alveolitis|hypersensitivity pneumonitis ,,disease_ontology,,DOID:841,,,,,,,,,,,,,,,,,,,extrinsic allergic alveolitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200638,"[""OR5M8 gene""]",,"An olfactory receptor 5M8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5M8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200638,,,,,,,,,,,,,,,,219484,OR5M8,,,,,,,,,,,OR5M8 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001403,"[""gastrula""]",,"An early metazoan embryo in which the ectoderm, mesoderm, and endoderm are established either by invagination of the blastula (as in fish and amphibians) to form a multilayered cellular cup with a blastopore opening into the archenteron or by differentiation of the blastodisc (as in reptiles, birds, and mammals) and inward cellular migration.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"An early metazoan embryo in which the ectoderm, mesoderm, and endoderm are established either by invagination of the blastula (as in fish and amphibians) to form a multilayered cellular cup with a blastopore opening into the archenteron or by differentiation of the blastodisc (as in reptiles, birds, and mammals) and inward cellular migration.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001403,,,,,,,BrendaTissueOBO,,BTO:0001403,,,,,,,,,,,,,,,,,,,gastrula,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12241,"[""beta thalassemia""]",,A thalassemia characterized by the reduced or absent synthesis of the beta globin chains of hemoglobin.,false,,,http://purl.obolibrary.org/obo/DOID_10241,,,,,,,,A thalassemia characterized by the reduced or absent synthesis of the beta globin chains of hemoglobin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12241,,,,SNOMEDCT_US_2016_03_01:191190000|ORDO:848|SNOMEDCT_US_2016_03_01:65959000|ICD9CM:282.44|ICD10CM:D56.1|MESH:D017086|OMIM:603902|NCI:C34375|OMIM:187550|UMLS_CUI:C0005283|OMIM:613985,,,disease_ontology,,DOID:12241,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,beta thalassemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000323,"[""PAK1 kinase domain""]",,P21 protein (Cdc42/Rac)-activated kinase 1; MGC130000; MGC130001; PAK1; PAKalpha,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,P21 protein (Cdc42/Rac)-activated kinase 1; MGC130000; MGC130001; PAK1; PAKalpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000323,,,,,,,,,,,,,,,,,,,200302,,,,,,,,,PAK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100091,"[""Casein kinase II subunit alpha""]",,A casein kinase II subunit alpha' that is encoded in the genome of human. |casein kinase ii subunit alpha (CSNK2A1)  with  no mutation  in a nonphosphorylated state|casein kinase ii subunit alpha (CSNK2A2)  with  no mutation  in a nonphosphorylated state,false,,,http://www.drugtargetontology.org/dto/DTO_03300142,,,,,,,,A casein kinase II subunit alpha' that is encoded in the genome of human. |casein kinase ii subunit alpha (CSNK2A1)  with  no mutation  in a nonphosphorylated state|casein kinase ii subunit alpha (CSNK2A2)  with  no mutation  in a nonphosphorylated state,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100091,,,,https://pharos.nih.gov/idg/targets/P68400,,,,,,,,,,,,,CSNK2A1,CK2A1,,P68400,,,,,,,,Casein kinase II subunit alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200359,"[""NEK5 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400197,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200359,,,,,,,,,,,,,,,,341676,NEK5,,,,,,,,,,,NEK5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8781,"[""rubella""]",,"A viral infectious disease that results_in infection located_in skin, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom rash on the face which spreads to the trunk and limbs, has_symptom fever, has_symptom lymphadenopathy, has_symptom joint pains, has_symptom headache, and has_symptom conjunctivitis.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in infection located_in skin, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom rash on the face which spreads to the trunk and limbs, has_symptom fever, has_symptom lymphadenopathy, has_symptom joint pains, has_symptom headache, and has_symptom conjunctivitis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8781,,,DOID:11765|DOID:1464|DOID:8780|DOID:8816|DOID:9179|DOID:9162|DOID:1463|DOID:9116|DOID:9106|DOID:8909,SNOMEDCT_US_2016_03_01:154343004|SNOMEDCT_US_2016_03_01:36653000|NCI:C85051|ICD10CM:B06|ICD10CM:B06.9|MESH:D012409|SNOMEDCT_US_2016_03_01:266192003|ICD9CM:056|UMLS_CUI:C0035920,german measles,,disease_ontology,,DOID:8781,,,,,,,,,,,,,,,,,,,rubella,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8893,"[""psoriasis""]",,"Xref MGI.
Update outdated UMLS CUI from C00295134 to C0033860.",false,,,http://purl.obolibrary.org/obo/DOID_37,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8893,,,,OMIM:614070|OMIM:612950|SNOMEDCT_US_2016_03_01:156369008|OMIM:177900|SNOMEDCT_US_2016_03_01:156371008|UMLS_CUI:C0033860|OMIM:612599|OMIM:602723|ICD10CM:L40|OMIM:605364|SNOMEDCT_US_2016_03_01:9014002|NCI:C3346|OMIM:604316|SNOMEDCT_US_2016_03_01:200978009|SNOMEDCT_US_2016_03_01:200961000|OMIM:605606|OMIM:607857|MESH:D011565|OMIM:610707|OMIM:601454|SNOMEDCT_US_2016_03_01:267851002|ICD10CM:L40.9|OMIM:612410|OMIM:603935|EFO:0000676,,,disease_ontology,,DOID:8893,,,,,,,,,,,,,,,,,"Xref MGI.
Update outdated UMLS CUI from C00295134 to C0033860.",,psoriasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200019,"[""AKT1 gene""]",,"The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400121,,,,,,,,"The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200019,,,,,,,,,,,,,,,,207,AKT1,PKB|RAC,,,,,,,,,,AKT1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80243,"[""Endothelin-3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG COMPOUND:C16013|KEGG COMPOUND:125692-40-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80243,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80243,,,,,Endothelin-3,,CHEBI:80243,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8469,"[""influenza""]",,"A viral infectious disease that results_in infection, located_in respiratory tract, has_material_basis_in Influenzavirus A, has_material_basis_in Influenzavirus B, or has_material_basis_in Influenzavirus C, which are transmitted_by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. It is a highly contagious disease that affects birds and mammals and has_symptom chills, has_symptom fever, has_symptom sore throat, has_symptom runny nose, has_symptom muscle pains, has_symptom severe headache, has_symptom cough, and has_symptom weakness.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in infection, located_in respiratory tract, has_material_basis_in Influenzavirus A, has_material_basis_in Influenzavirus B, or has_material_basis_in Influenzavirus C, which are transmitted_by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. It is a highly contagious disease that affects birds and mammals and has_symptom chills, has_symptom fever, has_symptom sore throat, has_symptom runny nose, has_symptom muscle pains, has_symptom severe headache, has_symptom cough, and has_symptom weakness.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8469,,,DOID:8468,SNOMEDCT_US_2016_03_01:195931008|ICD9CM:487|SNOMEDCT_US_2016_03_01:266353003|SNOMEDCT_US_2016_03_01:155562009|MESH:D007251|NCI:C53482|SNOMEDCT_US_2016_03_01:6142004|SNOMEDCT_US_2016_03_01:266393000|ICD10CM:J11.1|SNOMEDCT_US_2016_03_01:155559006|UMLS_CUI:C0021400,Influenza with other manifestations|Influenza with non-respiratory manifestation (disorder)|Influenza with other manifestations NOS (disorder)|Influenza with other manifestations (disorder)|flu|influenza with non-respiratory manifestation,,disease_ontology,,DOID:8469,,,,,,,,,,,,,,,,,,,influenza,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002651,"[""piriform area""]",,"An area in the rhinencephalon, pear-shaped in some species but not in humans; it includes the lateral olfactory process or gyrus, the limen insulae, the uncus, and part of the parahippocampal gyrus; subdivided into the prepiriform area, the periamygdaloid area, and the entorhinal area.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"An area in the rhinencephalon, pear-shaped in some species but not in humans; it includes the lateral olfactory process or gyrus, the limen insulae, the uncus, and part of the parahippocampal gyrus; subdivided into the prepiriform area, the periamygdaloid area, and the entorhinal area.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002651,,,,,,,BrendaTissueOBO,pyriform area|piriform lobe|pyriform lobe|piriform cortex,BTO:0002651,,,,,,,,,,,,,,,,,,,piriform area,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3702,"[""cervical adenocarcinoma""]",,A cervix carcinoma that derives_from epithelial cells of glandular origin.,false,,,http://purl.obolibrary.org/obo/DOID_2893,,,,,,,,A cervix carcinoma that derives_from epithelial cells of glandular origin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3702,,,,SNOMEDCT_US_2016_03_01:254887002|NCI:C4029|SNOMEDCT_US_2016_03_01:154522004|UMLS_CUI:C0279672|SNOMEDCT_US_2016_03_01:269596006,adenocarcinoma of the uterine Cervix|adenocarcinoma of cervix (disorder)|adenocarcinoma cervix uteri,,disease_ontology,,DOID:3702,,,,,,,,,,,,,,,,,,,cervical adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200027,"[""ADRA1A gene""]",,"An alpha-1A adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35348] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400093,,,,,,,,"An alpha-1A adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35348] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200027,,,,,,,,,,,,,,,,148,ADRA1A,ADRA1C,,,,,,,,,,ADRA1A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004676,"[""cerebral peduncle""]",,Either of two large bundles of nerve fibers passing from the pons forward and outward to form the main connection between the cerebral hemispheres and the spinal cord.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002191,,,,,,,,Either of two large bundles of nerve fibers passing from the pons forward and outward to form the main connection between the cerebral hemispheres and the spinal cord.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004676,mgr,2010-05-12T01:08:56Z,,,,,BrendaTissueOBO,,BTO:0004676,,,,,,,,,,,,,,,,,,,cerebral peduncle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005261,"[""B-lymphoblast cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005261,XPMUser,2011-10-03T09:25:46Z,,,,,BrendaTissueOBO,,BTO:0005261,,,,,,,,,,,,,,,,,,,B-lymphoblast cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400212,"[""WEE family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400212,,,,,,,,,,,,,,,,,,,,,,,,,,,,WEE family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100780,"[""Taste receptor type 2 member 19""]",,"A taste receptor type 2 member 19 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59542] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300014,,,,,,,,"A taste receptor type 2 member 19 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59542] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100780,,,,https://pharos.nih.gov/idg/targets/P59542,,,,,,,,,,,,,TAS2R19,TAS2R23|TAS2R48,,P59542,,,,,,,,Taste receptor type 2 member 19,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200343,"[""CDC42BPG gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400265,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200343,,,,,,,,,,,,,,,,55561,CDC42BPG,DMPK2,,,,,,,,,,CDC42BPG gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000895,"[""myelin membrane""]",,The multilamellar myelin membrane is a specialised lipid-rich domain of the glial cell plasma membrane.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The multilamellar myelin membrane is a specialised lipid-rich domain of the glial cell plasma membrane.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000895,,,,,,,BrendaTissueOBO,,BTO:0000895,,,,,,,,,,,,,,,,,,,myelin membrane,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100084,"[""D(4) dopamine receptor""]",,"A D(4) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21917] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300037,,,,,,,,"A D(4) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21917] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100084,,,,https://pharos.nih.gov/idg/targets/P21917,,,,,,,,,,,,,DRD4,,,P21917,,,,,,,,D(4) dopamine receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000823,"[""cerebral gray matter""]",,"Brownish-gray nerve tissue, especially of the brain and spinal cord, composed of nerve cell bodies and their dendrites and some supportive tissue.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Brownish-gray nerve tissue, especially of the brain and spinal cord, composed of nerve cell bodies and their dendrites and some supportive tissue.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000823,,,,,,,BrendaTissueOBO,cerebral grey matter|gray matter|grey matter,BTO:0000823,,,,,,,,,,,,,,,,,,,cerebral gray matter,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9744,"[""type 1 diabetes mellitus""]",,A diabetes mellitus that results from the body's failure to produce insulin and has_material_basis_in autoimmune destruction of insulin-producing beta cells of the pancreas.,false,,,http://purl.obolibrary.org/obo/DOID_9351,,,,,,,,A diabetes mellitus that results from the body's failure to produce insulin and has_material_basis_in autoimmune destruction of insulin-producing beta cells of the pancreas.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9744,,,,UMLS_CUI:C0011854|SNOMEDCT_US_2016_03_01:46635009|OMIM:300136|MESH:D003922|KEGG:04940|EFO:0001359|SNOMEDCT_US_2016_03_01:190362004|SNOMEDCT_US_2016_03_01:190322003|NCI:C2986|ICD10CM:E10|SNOMEDCT_US_2016_03_01:267469001|OMIM:222100|SNOMEDCT_US_2016_03_01:154673001,type I diabetes mellitus|IDDM|insulin-dependent diabetes mellitus,,disease_ontology,,DOID:9744,,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,type 1 diabetes mellitus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100619,"[""ATP-dependent 6-phosphofructokinase, platelet type""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100619,,,,,,,,,,,,,,,,,PFKP,,,Q01813,,,,,,,,"ATP-dependent 6-phosphofructokinase, platelet type",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2769,"[""tic disorder""]",,A specific developmental disorder that is characterized by the persistent presence of involuntary brief movements or sounds occuring intermittently and unpredictably out of a background of normal motor activity.,false,,,http://purl.obolibrary.org/obo/DOID_0060038,,,,,,,,A specific developmental disorder that is characterized by the persistent presence of involuntary brief movements or sounds occuring intermittently and unpredictably out of a background of normal motor activity.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2769,,,,SNOMEDCT_US_2016_03_01:568005|SNOMEDCT_US_2016_03_01:192621007|UMLS_CUI:C0040188|SNOMEDCT_US_2016_03_01:386783003|SNOMEDCT_US_2016_03_01:191989005|SNOMEDCT_US_2016_03_01:112086008|ICD10CM:F95|ICD9CM:307.20|SNOMEDCT_US_2016_03_01:192626002|SNOMEDCT_US_2016_03_01:35042001|ICD9CM:307.2|SNOMEDCT_US_2016_03_01:191991002|MESH:D013981|SNOMEDCT_US_2016_03_01:155005001|ICD10CM:F95.9|SNOMEDCT_US_2016_03_01:191988002|SNOMEDCT_US_2016_03_01:393585001,,,disease_ontology,,DOID:2769,,,,,,,,,,,,,,,,,,,tic disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3265,"[""chronic granulomatous disease""]",,"A phagocyte bactericidal dysfunction characterized by an inability to resist repeated infectious diseases and a tendency to develop chronic inflammation. Life-threatening recurrent fungal and bacterial infections affecting the skin, lungs, and bones may occur along with swollen areas of inflamed tissues known as granulomas that can be widely distributed.",false,,,http://purl.obolibrary.org/obo/DOID_3262,,,,,,,,"A phagocyte bactericidal dysfunction characterized by an inability to resist repeated infectious diseases and a tendency to develop chronic inflammation. Life-threatening recurrent fungal and bacterial infections affecting the skin, lungs, and bones may occur along with swollen areas of inflamed tissues known as granulomas that can be widely distributed.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3265,,,,OMIM:233700|OMIM:233710|ICD10CM:D71|UMLS_CUI:C0018203|OMIM:613960|SNOMEDCT_US_2016_03_01:387759001|SNOMEDCT_US_2016_03_01:191354002|SNOMEDCT_US_2016_03_01:191352003|ORDO:379|NCI:C26788|OMIM:233690|OMIM:306400|OMIM:138990|MESH:D006105|SNOMEDCT_US_2016_03_01:11210002,CGD|Quie syndrome|Congenital dysphagocytosis|Bridges-Good syndrome,,disease_ontology,,DOID:3265,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,chronic granulomatous disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300126,"[""RAF family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300107,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300126,,,,,,,,,,,,,,,,,,,,,,,,,,,,RAF family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9432,"[""renal glycosuria""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_447,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9432,,,,UMLS_CUI:C0017980|MESH:D006030|SNOMEDCT_US_2016_03_01:1913007|SNOMEDCT_US_2016_03_01:367418000|OMIM:233100|ICD10CM:E74.8|ICD9CM:271.4|SNOMEDCT_US_2016_03_01:154737003|SNOMEDCT_US_2016_03_01:236367002|SNOMEDCT_US_2016_03_01:267430007|SNOMEDCT_US_2016_03_01:190759004,renal diabetes,,disease_ontology,,DOID:9432,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,renal glycosuria,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_15355,"[""Acetylcholine""]","2-acetyloxyethyl(trimethyl)ammonium|Azetylcholin|
InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1
|Acetyl choline ion|2-acetyloxyethyl(trimethyl)azanium|2-(acetyloxy)-N,N,N-trimethylethanaminium|choline acetate|CC(=O)OCC[N+](C)(C)C|C7H16NO2|OIPILFWXSMYKGL-UHFFFAOYSA-N|O-Acetylcholine|2-acetoxyethyl(trimethyl)ammonium|Acetylcholinium: acetyl-Choline|ACh|Choline acetate (ester)|Acetylcholine cation|[2-(acetyloxy)ethyl]trimethylazanium","
Actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter.
",false,,,http://purl.obolibrary.org/obo/CHEBI_32952,,,,,,,HMDB:HMDB00895|CiteXplore:17284361|CiteXplore:15231705|CiteXplore:15556286|CiteXplore:16362770|KEGG COMPOUND:C01996|CiteXplore:20963497|CiteXplore:15288882|ChemIDplus:1764436|CiteXplore:21545631|Wikipedia:Acetylcholine|CiteXplore:18050502|KEGG COMPOUND:51-84-3|CiteXplore:8331294|CiteXplore:21601579|CiteXplore:11228162|CiteXplore:21130809|DrugBank:DB03128|CiteXplore:15014918|CiteXplore:15013569|CiteXplore:15894309|CiteXplore:17011181|CiteXplore:21246223|MetaCyc:ACETYLCHOLINE|CiteXplore:15675987|CiteXplore:15008956|CiteXplore:16275899|PDBeChem:ACH|Gmelin:326108|CiteXplore:15210062|CiteXplore:19255787|CiteXplore:14764638|CiteXplore:11348607|CiteXplore:8500722|CiteXplore:18407448|CiteXplore:14698651|CiteXplore:15361288|ChemIDplus:51-84-3,"
Actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:22197|CHEBI:2416|CHEBI:12686|CHEBI:13715|CHEBI:40559,,"ACETYLCHOLINE|acetylcholine|Acetylcholine|2-acetyloxy-N,N,N-trimethylethanaminium",,chebi_ontology,"2-acetyloxyethyl(trimethyl)ammonium|Azetylcholin|
InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1
|Acetyl choline ion|2-acetyloxyethyl(trimethyl)azanium|2-(acetyloxy)-N,N,N-trimethylethanaminium|choline acetate|CC(=O)OCC[N+](C)(C)C|C7H16NO2|OIPILFWXSMYKGL-UHFFFAOYSA-N|O-Acetylcholine|2-acetoxyethyl(trimethyl)ammonium|Acetylcholinium: acetyl-Choline|ACh|Choline acetate (ester)|Acetylcholine cation|[2-(acetyloxy)ethyl]trimethylazanium",,,CHEBI:15355,,,,,,,,,,,,,,,,,,,,,,,CHEBI:15355,,,,,acetylcholine|Acetylcholine,,CHEBI:15355,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11184,"[""acute conjunctivitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_6195,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11184,,,,UMLS_CUI:C0029668|ICD10CM:H10.02|ICD9CM:372.03,,,disease_ontology,,DOID:11184,,,,,,,,,,,,,,,,,,,acute conjunctivitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200293,"[""MAP4K1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400287,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200293,,,,,,,,,,,,,,,,11184,MAP4K1,HPK1,,,,,,,,,,MAP4K1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9240,"[""erythromelalgia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_341,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9240,,,,ICD9CM:443.82|NCI:C34593|MESH:D004916|SNOMEDCT_US_2016_03_01:37151006|ICD10CM:I73.81|UMLS_CUI:C0014804|SNOMEDCT_US_2016_03_01:238777005,,,disease_ontology,,DOID:9240,,,,,,,,,,,,,,,,,,,erythromelalgia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100344,"[""Serine/threonine-protein kinase 26""]",,serine/threonine-protein kinase mst4 (MST4)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase MST4 that is encoded in the genome of human. [PRO:WCB] ,false,,,http://www.drugtargetontology.org/dto/DTO_03300297,,,,,,,,serine/threonine-protein kinase mst4 (MST4)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase MST4 that is encoded in the genome of human. [PRO:WCB] ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100344,,,,https://pharos.nih.gov/idg/targets/Q9P289,,,,,,,,,,,,,MST4,MASK|MST4|STK26,,Q9P289,,,,,,,,Serine/threonine-protein kinase 26,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001073,"[""hypophysis""]",,"A small oval endocrine organ that is attached to the infundibulum of the brain, consists of an epithelial anterior lobe joined by an intermediate part to a posterior lobe of nervous origin, and produces various internal secretions directly or indirectly impinging on most basic body functions.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001488,,,,,,,,"A small oval endocrine organ that is attached to the infundibulum of the brain, consists of an epithelial anterior lobe joined by an intermediate part to a posterior lobe of nervous origin, and produces various internal secretions directly or indirectly impinging on most basic body functions.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001073,,,,,,,BrendaTissueOBO,pituitary body|pituitary gland|hypophysis cerebri|pituitary|glandula pituitaria,BTO:0001073,,,,,,,,,,,,,,,,,,,hypophysis,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1556,"[""arthus reaction""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1557,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1556,,,,NCI:C34400|UMLS_CUI:C0003907|ICD9CM:995.21|SNOMEDCT_US_2016_03_01:29548007|SNOMEDCT_US_2016_03_01:402413008|MESH:D001183|ICD10CM:T78.41,Arthus reaction (function)|Arthus type urticaria|Arthus Phenomenon|Arthus phenomenon,,disease_ontology,,DOID:1556,,,,,,,,,,,,,,,,,,,arthus reaction,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300173,"[""PKG family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300173,,,,,,,,,,,,,,,,,,,,,,,,,,,,PKG family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200162,"[""GPR162 gene""]",,"A G-protein coupled receptor 162 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q16538] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400052,,,,,,,,"A G-protein coupled receptor 162 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q16538] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200162,,,,,,,,,,,,,,,,27239,GPR162,GRCA,,,,,,,,,,GPR162 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100387,"[""Olfactory receptor 51b2""]",,"An olfactory receptor 51B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y5P1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 51B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y5P1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100387,,,,https://pharos.nih.gov/idg/targets/Q9Y5P1,,,,,,,,,,,,,OR51B2,OR51B1P,,Q9Y5P1,,,,,,,,Olfactory receptor 51b2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/UBERON_0000056,"[""ureter""]",metanephric duct,"Muscular duct that propels urine from the kidneys to the urinary bladder, or related organs. In humans, organ with organ cavity which connects the renal sinus to the urinary bladder. Examples: the right and the left ureters.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,http://en.wikipedia.org/wiki/Ureter|http://linkedlifedata.com/resource/umls/id/C0041951|http://www.snomedbrowser.com/Codes/Details/302511008|XAO:0000144|EV:0100097|MAT:0000120|ncithesaurus:Ureter|OpenCyc:Mx4rvhmm6JwpEbGdrcN5Y29ycA|FMA:9704|MA:0000378|galen:Ureter|EMAPA:17950|BTO:0001409|EHDAA2:0002139|EFO:0000930|EHDAA:9341|CALOHA:TS-1084|MESH:A05.810.776|MIAA:0000120|AAO:0010254|UMLS:C0041951|GAID:438|VHOG:0000605,"Muscular duct that propels urine from the kidneys to the urinary bladder, or related organs. In humans, organ with organ cavity which connects the renal sinus to the urinary bladder. Examples: the right and the left ureters.",,http://upload.wikimedia.org/wikipedia/commons/3/30/Urinary_system.svg|http://upload.wikimedia.org/wikipedia/commons/thumb/3/30/Urinary_system.svg/200px-Urinary_system.svg.png,,,,,,,,"Anatomical structure consisting of long narrow duct which carries urine from the kidney to the urinary bladder.[AAO]|The duct of amniotes that carries urine from a metanephric kidney to the urinary bladder. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]",,,,,,,,,,,,,,,,,,,,,,,,,,,,uberon,metanephric duct,ureteral|ureteric,"The first embryonic hint of a metanephros is the formation of the metanephric duct that appears as a ureteric diverticulum arising at the base of preexisting mesonephric duct. The ureteric diverticulum grows dorsally into the posterior region of the nephric ridge. Here it enlarges and stimulates the growth of metanephric tubules that come to make up the metanephric kidney. The metanephros becomes the adult kidney of amniotes, and the metanephric duct is usually called the ureter.[well established][VHOG]",,,,,,,,,,,,,,,,,,,,,,,,UBERON:0000056,,,,,ureter,,UBERON:0000056,,http://purl.obolibrary.org/obo/uberon.owl,http://purl.obolibrary.org/obo/uberon/core#efo_slim|http://purl.obolibrary.org/obo/uberon/core#organ_slim|http://purl.obolibrary.org/obo/uberon/core#major_organ|http://purl.obolibrary.org/obo/uberon/core#uberon_slim,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000046,"[""AURKC kinase domain""]",,Aurora kinase C; AIE2; AIK3; ARK3; Aur3; AurC; AurC/Aur3; AURKC; aurora-C; STK13,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Aurora kinase C; AIE2; AIK3; ARK3; Aur3; AurC; AurC/Aur3; AURKC; aurora-C; STK13,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000046,,,,,,,,,,,,,,,,,,,200046,,,,,,,,,AURKC kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100278,"[""Neuropeptide ff receptor 1""]",,"A neuropeptide FF receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9GZQ6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300069,,,,,,,,"A neuropeptide FF receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9GZQ6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100278,,,,https://pharos.nih.gov/idg/targets/Q9GZQ6,,,,,,,,,,,,,NPFFR1,GPR147|NPFF1,,Q9GZQ6,,,,,,,,Neuropeptide ff receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400421,"[""KCNJ10 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400421,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ10 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060365,"[""mandibulofacial dysostosis with alopecia""]",,"A syndrome characterized_by malar and mandibular hypoplasia, typically associated with abnormalities of the ears and eyelids, and with alopecia.",false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,"A syndrome characterized_by malar and mandibular hypoplasia, typically associated with abnormalities of the ears and eyelids, and with alopecia.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060365,elvira,2015-09-17T16:20:00Z,,OMIM:616367,MFDA,,disease_ontology,,DOID:0060365,,,,,,,,,,,,,,,,,,,mandibulofacial dysostosis with alopecia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060366,"[""Hennekam syndrome""]",,"A lymphatic system disease characterized by he presence of intestinal lymphangiectasia, mental retardation, and characteristic facial anomalies. It is inherited in an autosomal recessive pattern. Most individuals with Hennekam syndrome have characteristic facial abnormalities, such as a flat face with accompanying puffy eyelids and hypertelorism; the nasal bridge is typically flat and the ears are typically small. Congenital extremity and genital lymphedema is present in most patients.",false,,,http://purl.obolibrary.org/obo/DOID_75,,,,,,,,"A lymphatic system disease characterized by he presence of intestinal lymphangiectasia, mental retardation, and characteristic facial anomalies. It is inherited in an autosomal recessive pattern. Most individuals with Hennekam syndrome have characteristic facial abnormalities, such as a flat face with accompanying puffy eyelids and hypertelorism; the nasal bridge is typically flat and the ears are typically small. Congenital extremity and genital lymphedema is present in most patients.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060366,elvira,2015-09-17T16:36:59Z,,OMIM:616006|SNOMEDCT_US_2016_03_01:234146006|OMIM:235510|UMLS_CUI:C0340834|MESH:C537255|ORDO:2136,lymphedem-lymphangiectasia-intellectual disability syndrome|Hennekam lymphangiectasia-lymphedema syndrome,,disease_ontology,,DOID:0060366,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,Hennekam syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060363,"[""glycerol kinase deficiency""]",,"An inherited metabolic disorder characterized_by wide range of phenotypic variability; patients can have severe metabolic and CNS abnormalities, while others possess hyperglycerolemia and glyceroluria with no other apparent phenotype. It has material basis in mutation in the GK gene on chromosome Xp21.",false,,,http://purl.obolibrary.org/obo/DOID_655,,,,,,,,"An inherited metabolic disorder characterized_by wide range of phenotypic variability; patients can have severe metabolic and CNS abnormalities, while others possess hyperglycerolemia and glyceroluria with no other apparent phenotype. It has material basis in mutation in the GK gene on chromosome Xp21.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060363,elvira,2015-09-17T15:45:20Z,,SNOMEDCT_US_2016_03_01:297256008|ORDO:408|OMIM:307030|UMLS_CUI:C0574108,,,disease_ontology,,DOID:0060363,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,glycerol kinase deficiency,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400307,"[""PDK1 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400203,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400307,,,,,,,,,,,,,,,,,,,,,,,,,,,,PDK1 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100171,"[""Putative G-protein coupled receptor GPR32P1""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100171,,,,https://pharos.nih.gov/idg/targets/Q8NGA4,,,,,,,,,,,,,GPR32P1,,,Q8NGA4,,,,,,,,Putative G-protein coupled receptor GPR32P1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100119,"[""Growth hormone-releasing hormone receptor""]",,"A growth hormone-releasing hormone receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02643] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300047,,,,,,,,"A growth hormone-releasing hormone receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02643] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100119,,,,https://pharos.nih.gov/idg/targets/Q02643,,,,,,,,,,,,,GHRHR,,,Q02643,,,,,,,,Growth hormone-releasing hormone receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200534,"[""OR2L2 gene""]",,"An olfactory receptor 2L2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH16] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2L2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH16] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200534,,,,,,,,,,,,,,,,26246,OR2L2,OR2L12|OR2L4P,,,,,,,,,,OR2L2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100082,"[""D(2) dopamine receptor""]",,"A D(2) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P14416] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300037,,,,,,,,"A D(2) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P14416] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100082,,,,https://pharos.nih.gov/idg/targets/P14416,,,,,,,,,,,,,DRD2,,,P14416,,,,,,,,D(2) dopamine receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200070,"[""CLCNKA gene""]",,"This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400393,,,,,,,,"This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200070,,,,,,,,,,,,,,,,1187,CLCNKA,,,,,,,,,,,CLCNKA gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1485,"[""cystic fibrosis""]",,"An autosomal recessive disease that is characterized by the buildup of thick, sticky mucus that can damage many organs.",false,,,http://purl.obolibrary.org/obo/DOID_0050737,,,,,,,,"An autosomal recessive disease that is characterized by the buildup of thick, sticky mucus that can damage many organs.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1485,,,DOID:1484|DOID:13383|DOID:12447|DOID:14395,ICD10CM:E84.9|SNOMEDCT_US_2016_03_01:154767009|NCI:C2975|SNOMEDCT_US_2016_03_01:190905008|MESH:D003550|OMIM:219700|ICD10CM:E84|UMLS_CUI:C0010674|SNOMEDCT_US_2016_03_01:190911006|SNOMEDCT_US_2016_03_01:85809002|ICD9CM:277.0,CF|mucoviscidosis,,disease_ontology,,DOID:1485,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,cystic fibrosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100057,"[""Voltage-dependent calcium channel gamma-3 subunit""]",,"A voltage-dependent calcium channel gamma-3 subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60359] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300336,,,,,,,,"A voltage-dependent calcium channel gamma-3 subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60359] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100057,,,,https://pharos.nih.gov/idg/targets/O60359,,,,,,,,,,,,,CACNG3,,,O60359,,,,,,,,Voltage-dependent calcium channel gamma-3 subunit,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80127,"[""Angiotensin IV""]","Angiotensin II, 1-des-asn-2-arg",,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C15849|CAS:12676-15-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,"Angiotensin II, 1-des-asn-2-arg",,,CHEBI:80127,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80127,,,,,Angiotensin IV,,CHEBI:80127,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000398,"[""RSK3(Kin.Dom.1-N-terminal) kinase domain""]",,"Ribosomal protein S6 kinase, 90kDa, polypeptide 2; HU-2; MAPKAPK1C; p90RSK; p90-RSK3; pp90RSK3; RPS6KA2; RSK; RSK1; RSK1/p90RSK; RSK3; S6K-alpha; S6K-alpha2",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Ribosomal protein S6 kinase, 90kDa, polypeptide 2; HU-2; MAPKAPK1C; p90RSK; p90-RSK3; pp90RSK3; RPS6KA2; RSK; RSK1; RSK1/p90RSK; RSK3; S6K-alpha; S6K-alpha2",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000398,,,,,,,,,,,,,,,,,,,"200386, 200402",,,,,,,,,RSK3(Kin.Dom.1-N-terminal) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100643,"[""Olfactory receptor 5P3""]",,"An olfactory receptor 5P3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZ94] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5P3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZ94] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100643,,,,https://pharos.nih.gov/idg/targets/Q8WZ94,,,,,,,,,,,,,OR5P3,,,Q8WZ94,,,,,,,,Olfactory receptor 5P3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_438,"[""autoimmune disease of the nervous system""]",,,false,,,http://purl.obolibrary.org/obo/DOID_417,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:438,,,,MESH:D020274|UMLS_CUI:C0751871|NCI:C99383,,,disease_ontology,autoimmune nervous system disorder,DOID:438,,,,,,,,,,,,,,,,,,,autoimmune disease of the nervous system,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_437,"[""myasthenia gravis""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_439|http://purl.obolibrary.org/obo/DOID_0060033,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:437,,,DOID:443|DOID:444,ICD10CM:G70.0|UMLS_CUI:C0026896|ICD9CM:358.0|SNOMEDCT_US_2016_03_01:155092009|MESH:D009157|OMIM:254200|NCI:C60989|SNOMEDCT_US_2016_03_01:91637004|UMLS_CUI:C1260409|ICD10CM:G70.00|SNOMEDCT_US_2016_03_01:193208002|ICD9CM:358.00,,,disease_ontology,,DOID:437,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,myasthenia gravis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_439,"[""neuromuscular junction disease""]",,A neuromuscular disease that is characterized by the disfunction of conduction through the neuromuscular junction.,false,,,http://purl.obolibrary.org/obo/DOID_440,,,,,,,,A neuromuscular disease that is characterized by the disfunction of conduction through the neuromuscular junction.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:439,,,,UMLS_CUI:C0751950|SNOMEDCT_US_2016_03_01:128213006|MESH:D020511,,,disease_ontology,,DOID:439,,,,,,,,,,,,,,,,,,,neuromuscular junction disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300187,"[""STE20 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300113,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300187,,,,,,,,,,,,,,,,,,,,,,,,,,,,STE20 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12098,"[""trigeminal neuralgia""]",,OMIM mapping confirmed by DO. [LS].,false,,,http://purl.obolibrary.org/obo/DOID_561,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12098,,,,OMIM:190400|SNOMEDCT_US_2016_03_01:193090007|SNOMEDCT_US_2016_03_01:31681005|SNOMEDCT_US_2016_03_01:155066002|ICD9CM:350.1|ICD10CM:G50.0|MESH:D014277|SNOMEDCT_US_2016_03_01:322769008|UMLS_CUI:C0040997,trifocal neuralgia|Trigeminal neuralgia (disorder)|Trigeminal neuralgia [no drugs here] (disorder)|Trigeminal neuralgia|Trigeminal neuralgia NOS (disorder)|Trifacial neuralgia,,disease_ontology,,DOID:12098,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,trigeminal neuralgia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001742,"[""jejunal mucosa""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0000642|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001742,,,,,,,BrendaTissueOBO,,BTO:0001742,,,,,,,,,,,,,,,,,,,jejunal mucosa,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300386,"[""CACNA1F subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300333,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300386,,,,,,,,,,,,,,,,,,,,,,,,,,,,CACNA1F subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004094,"[""epithelial ovarian cancer cell""]",,Cancer that occurs in the cells on the surface of the ovary.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001023,,,,,,,,Cancer that occurs in the cells on the surface of the ovary.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004094,,,,,,,BrendaTissueOBO,ovarian epithelial cancer cell|EOC cell,BTO:0004094,,,,,,,,,,,,,,,,,,,epithelial ovarian cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100113,"[""Gamma-aminobutyric acid type B receptor subunit 1""]",,"A gamma-aminobutyric acid type B receptor subunit 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UBS5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300045,,,,,,,,"A gamma-aminobutyric acid type B receptor subunit 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UBS5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100113,,,,https://pharos.nih.gov/idg/targets/Q9UBS5,,,,,,,,,,,,,GABBR1,GPRC3A,,Q9UBS5,,,,,,,,Gamma-aminobutyric acid type B receptor subunit 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100279,"[""Neuropeptide FF receptor 2""]",,"A neuropeptide FF receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5X5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300069,,,,,,,,"A neuropeptide FF receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5X5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100279,,,,https://pharos.nih.gov/idg/targets/Q9Y5X5,,,,,,,,,,,,,NPFFR2,GPR74|NPFF2|NPGPR,,Q9Y5X5,,,,,,,,Neuropeptide FF receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200451,"[""RIPK2 gene""]",,"This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400124,,,,,,,,"This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200451,,,,,,,,,,,,,,,,8767,RIPK2,CARDIAK|RICK|RIP2,,,,,,,,,,RIPK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200213,"[""KCNK1 gene""]",,"This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400359,,,,,,,,"This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200213,,,,,,,,,,,,,,,,3775,KCNK1,HOHO1|KCNO1|TWIK1,,,,,,,,,,KCNK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002694,"[""leiomyoma cell""]",,"A benign tumor derived from smooth muscle, most commonly of the uterus.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A benign tumor derived from smooth muscle, most commonly of the uterus.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002694,,,,,,,BrendaTissueOBO,fibroid tumor cell|fibroid cell,BTO:0002694,,,,,,,,,,,,,,,,,,,leiomyoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14115,"[""toxic shock syndrome""]",,"A commensal bacterial infectious disease that results_in infection, has_material_basis_in Streptococcus pyogenes or has_material_basis_in Staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has_symptom fever, has_symptom rash, has_symptom hypotension, has_symptom multiorgan failure, has_symptom desquamation, has_symptom vomiting, has_symptom diarrhea, has_symptom headache, and has_symptom nonfocal neurologic abnormalities.",false,,,http://purl.obolibrary.org/obo/DOID_0050339,,,,,,,,"A commensal bacterial infectious disease that results_in infection, has_material_basis_in Streptococcus pyogenes or has_material_basis_in Staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has_symptom fever, has_symptom rash, has_symptom hypotension, has_symptom multiorgan failure, has_symptom desquamation, has_symptom vomiting, has_symptom diarrhea, has_symptom headache, and has_symptom nonfocal neurologic abnormalities.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14115,,,,NCI:C35498|ICD10CM:A48.3|UMLS_CUI:C0600327|MESH:D012772|SNOMEDCT_US_2016_03_01:18504008|ICD9CM:040.82,toxic shock|Toxic shock syndrome (disorder)|Toxic shock syndrome|TSS|Toxic Shock syndrome,,disease_ontology,,DOID:14115,http://purl.obolibrary.org/obo/doid#gram-positive_bacterial_infectious_disease,,,,,,,,,,,,,,,,,,toxic shock syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000256,"[""myoblast cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000256,,,,,,,BrendaTissueOBO,,BTO:0000256,,,,,,,,,,,,,,,,,,,myoblast cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11724,"[""limb-girdle muscular dystrophy""]",,A muscular dystrophy that is characterized by weakening of the muscles of the hip and shoulders which comprise the limb girdle muscles.,false,,,http://purl.obolibrary.org/obo/DOID_9884,,,,,,,,A muscular dystrophy that is characterized by weakening of the muscles of the hip and shoulders which comprise the limb girdle muscles.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11724,,,,ICD10CM:G71.0|ORDO:263|SNOMEDCT_US_2016_03_01:93153005|SNOMEDCT_US_2016_03_01:56096001|NCI:C84828|UMLS_CUI:C0686353|MESH:D049288,Leyden-Mbius muscular dystrophy|limb girdle muscular dystrophy|Erb's muscular dystrophy,,disease_ontology,,DOID:11724,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,limb-girdle muscular dystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11722,"[""myotonic dystrophy type 1""]",,"A myotonic disease that is characterized by progressive muscle wasting and weakness affecting the distal skeletal and smooth muscles of lower legs, hands, neck, and face along with myotonia and cataracts and has_physical_basis_in the autosomal dominant inheritance of the DMPK gene containing an expansion of a CTG trinucleotide repeat in the non-coding region.",false,,,http://purl.obolibrary.org/obo/DOID_450,,,,,,,,"A myotonic disease that is characterized by progressive muscle wasting and weakness affecting the distal skeletal and smooth muscles of lower legs, hands, neck, and face along with myotonia and cataracts and has_physical_basis_in the autosomal dominant inheritance of the DMPK gene containing an expansion of a CTG trinucleotide repeat in the non-coding region.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11722,,,,NCI:C84914|SNOMEDCT_US_2016_03_01:77956009|SNOMEDCT_US_2016_03_01:155096007|UMLS_CUI:C0027126|OMIM:160900|ICD9CM:359.21|SNOMEDCT_US_2016_03_01:267713009|MESH:D009223|ICD10CM:G71.11,Steinert disease|Dystrophia myotonica|congenital myotonic dystrophy|myotonic dystrophy of Steinert,,disease_ontology,,DOID:11722,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,myotonic dystrophy type 1,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11723,"[""Duchenne muscular dystrophy""]",,A muscular dystrophy that has_material_basis_in X-linked disease that has material basis in mutations in the DMD gene found on the X chromosome. It is characterized by rapidly progressing muscle weakness and muscle atrophy initially involving the lower extremities and eventually affecting the whole body. It affects males whereas females can be carriers. The symptoms start before the age of six and may appear at infancy.,false,,,http://purl.obolibrary.org/obo/DOID_9884,,,,,,,,A muscular dystrophy that has_material_basis_in X-linked disease that has material basis in mutations in the DMD gene found on the X chromosome. It is characterized by rapidly progressing muscle weakness and muscle atrophy initially involving the lower extremities and eventually affecting the whole body. It affects males whereas females can be carriers. The symptoms start before the age of six and may appear at infancy.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11723,,,,NCI:C75482|OMIM:310200|SNOMEDCT_US_2016_03_01:129619006|SNOMEDCT_US_2016_03_01:387732009|MESH:D020388|SNOMEDCT_US_2016_03_01:155095006|SNOMEDCT_US_2016_03_01:76670001|UMLS_CUI:C0013264|SNOMEDCT_US_2016_03_01:267712004,"Muscular dystrophy, Duchenne",,disease_ontology,,DOID:11723,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Duchenne muscular dystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11729,"[""Lyme disease""]",,"A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia burgdorferi, which is transmitted_by blacklegged tick (Ixodes scapularis) or transmitted_by western blacklegged tick (Ixodes pacificus). The infection has_symptom fever, has_symptom headache, has_symptom fatigue, and has_symptom skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system.",false,,,http://purl.obolibrary.org/obo/DOID_37|http://purl.obolibrary.org/obo/DOID_0050338,,,,,,,,"A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia burgdorferi, which is transmitted_by blacklegged tick (Ixodes scapularis) or transmitted_by western blacklegged tick (Ixodes pacificus). The infection has_symptom fever, has_symptom headache, has_symptom fatigue, and has_symptom skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11729,,,DOID:12233,ICD9CM:088.81|SNOMEDCT_US_2016_03_01:154376000|ICD10CM:A69.20|UMLS_CUI:C0752235|MESH:D008193|SNOMEDCT_US_2016_03_01:48982009|MESH:D020852|SNOMEDCT_US_2016_03_01:240672009|SNOMEDCT_US_2016_03_01:23502006|UMLS_CUI:C0024198|ICD10CM:A69.2|NCI:C45161,lyme neuroborreliosis|Bannworth's syndrome|Bannwarth syndrome (disorder)|Lyme borreliosis|neuroborreliosis|Neurological Lyme disease,,disease_ontology,,DOID:11729,http://purl.obolibrary.org/obo/doid#tick-borne_infectious_disease|http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease|http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,Lyme disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11726,"[""Emery-Dreifuss muscular dystrophy""]",,A muscular dystrophy that chiefly affects muscles used for movement (skeletal) and heart (cardiac) muscle.,false,,,http://purl.obolibrary.org/obo/DOID_9884,,,,,,,,A muscular dystrophy that chiefly affects muscles used for movement (skeletal) and heart (cardiac) muscle.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11726,,,,OMIM:614302|UMLS_CUI:C0410189|ORDO:98855|NCI:C84685|SNOMEDCT_US_2016_03_01:193233004|SNOMEDCT_US_2016_03_01:129620000|ORDO:261|OMIM:300696|OMIM:612999|OMIM:181350|MESH:D020389|ORDO:98863|SNOMEDCT_US_2016_03_01:111508004|OMIM:612998|OMIM:310300|ORDO:98853,EDMD,,disease_ontology,,DOID:11726,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,Emery-Dreifuss muscular dystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11721,"[""glycogen storage disease VII""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_2747,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11721,,,,OMIM:232800|NCI:C118437|MESH:D006014|ICD10CM:E74.09|SNOMEDCT_US_2016_03_01:89597008|SNOMEDCT_US_2016_03_01:234406005|UMLS_CUI:C0017926,"Muscle phosphofructokinase deficiency (disorder)|glycogen storage disease type VII|Glycogen storage disease, type VII (disorder)|phosphofructokinase myopathy",,disease_ontology,,DOID:11721,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,glycogen storage disease VII,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02402004,"[""5-HT5 receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400017,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02402004,,,,,,,,,,,,,,,,,,,,,,,,,,,,5-HT5 receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000049,"[""Gastrin releasing peptide(14-27) (human)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000049,,,,,,,,,,,,,,,,,,,,,,,,,,,,Gastrin releasing peptide(14-27) (human),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300248,"[""ABC1-C subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300120,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300248,,,,,,,,,,,,,,,,,,,,,,,,,,,,ABC1-C subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100428,"[""Serine/threonine-protein kinase n2""]",,"serine/threonine-protein kinase n2 (PKN2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase N2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16513] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300210,,,,,,,,"serine/threonine-protein kinase n2 (PKN2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase N2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16513] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100428,,,,https://pharos.nih.gov/idg/targets/Q16513,,,,,,,,,,,,,PKN2,PRK2|PRKCL2,,Q16513,,,,,,,,Serine/threonine-protein kinase n2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005085,"[""common penile artery""]",,"The artery that serves blood to the penis. It subdivides into three arteries, the bulbourethral artery, the dorsal artery of the penis and the cavernosal artery.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The artery that serves blood to the penis. It subdivides into three arteries, the bulbourethral artery, the dorsal artery of the penis and the cavernosal artery.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005085,XPMUser,2011-03-08T08:35:13Z,,,,,BrendaTissueOBO,penile artery,BTO:0005085,,,,,,,,,,,,,,,,,,,common penile artery,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200044,"[""BRS3 gene""]",,"A bombesin receptor subtype-3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32247] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400026,,,,,,,,"A bombesin receptor subtype-3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32247] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200044,,,,,,,,,,,,,,,,680,BRS3,,,,,,,,,,,BRS3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200560,"[""OR2Z1 gene""]",,"An olfactory receptor 2Z1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG97] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2Z1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG97] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200560,,,,,,,,,,,,,,,,284383,OR2Z1,OR2Z2,,,,,,,,,,OR2Z1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100029,"[""K546 in PIK3CA(Q546K)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100029,,,,,,,,,,,,,,,,,,,,,,,,,,,,K546 in PIK3CA(Q546K),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100253,"[""Membrane protein MLC1""]",,"A membrane protein MLC1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15049] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300362,,,,,,,,"A membrane protein MLC1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15049] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100253,,,,https://pharos.nih.gov/idg/targets/Q15049,,,,,,,,,,,,,MLC1,KIAA0027|WKL1,,Q15049,,,,,,,,Membrane protein MLC1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200630,"[""OR5K1 gene""]",,"An olfactory receptor 5K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHB7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHB7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200630,,,,,,,,,,,,,,,,26339,OR5K1,,,,,,,,,,,OR5K1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100544,"[""Olfactory receptor 2s2""]",,"An olfactory receptor 2S2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NQN1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2S2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NQN1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100544,,,,https://pharos.nih.gov/idg/targets/Q9NQN1,,,,,,,,,,,,,OR2S2,,,Q9NQN1,,,,,,,,Olfactory receptor 2s2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200011,"[""HTR6 gene""]",,"A 5-hydroxytryptamine receptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P50406] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402005,,,,,,,,"A 5-hydroxytryptamine receptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P50406] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200011,,,,,,,,,,,,,,,,3362,HTR6,,,,,,,,,,,HTR6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100612,"[""Nucleoside diphosphate kinase 6""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100612,,,,,,,,,,,,,,,,,NME6,,,O75414,,,,,,,,Nucleoside diphosphate kinase 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003053,"[""NCI-N87 cell""]",,NCI-N87 is a gastric carcinoma cell line derived in 1976 by A. Gazdar and associates at the National Cancer Institute from a liver metastasis of a well differentiated carcinoma of the stomach taken prior to cytotoxic therapy. The tumor was passaged as a xenograft in athymic nude mice for three passages before the cell line was established.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000787,,,,,,,,NCI-N87 is a gastric carcinoma cell line derived in 1976 by A. Gazdar and associates at the National Cancer Institute from a liver metastasis of a well differentiated carcinoma of the stomach taken prior to cytotoxic therapy. The tumor was passaged as a xenograft in athymic nude mice for three passages before the cell line was established.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003053,,,,,,,BrendaTissueOBO,,BTO:0003053,,,,,,,,,,,,,,,,,,,NCI-N87 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001555,"[""endometrial cancer cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0001996|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001555,Marion,2010-01-28T06:07:46Z,,,,,BrendaTissueOBO,endometrial carcinoma cell line,BTO:0001555,,,,,,,,,,,,,,,,,,,endometrial cancer cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300361,"[""MCU family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300361,,,,,,,,,,,,,,,,,,,,,,,,,,,,MCU family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100203,"[""Potassium voltage-gated channel subfamily G member 3""]",,"A voltage-gated potassium channel KCNG3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8TAE7] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300551,,,,,,,,"A voltage-gated potassium channel KCNG3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8TAE7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100203,,,,https://pharos.nih.gov/idg/targets/Q8TAE7,,,,,,,,,,,,,KCNG3,,,Q8TAE7,,,,,,,,Potassium voltage-gated channel subfamily G member 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000202,"[""sense organ""]",,A bodily structure that receives a stimulus (as heat or sound waves) and is affected in such a manner as to initiate a wave of excitation in associated sensory nerve fibers which convey specific impulses to the central nervous system where they are interpreted as corresponding sensations: RECEPTOR.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A bodily structure that receives a stimulus (as heat or sound waves) and is affected in such a manner as to initiate a wave of excitation in associated sensory nerve fibers which convey specific impulses to the central nervous system where they are interpreted as corresponding sensations: RECEPTOR.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000202,,,,,,,BrendaTissueOBO,Sinnesorgan,BTO:0000202,,,,,,,,,,,,,,,,,,,sense organ,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200059,"[""CDK13 gene""]",,"The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described.[provided by RefSeq, Dec 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400255,,,,,,,,"The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described.[provided by RefSeq, Dec 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200059,,,,,,,,,,,,,,,,8621,CDK13,CDC2L|CDC2L5|CHED,,,,,,,,,,CDK13 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100252,"[""Ribosomal protein s6 kinase alpha-2""]",,"ribosomal protein s6 kinase alpha-2 (RSK3(Kin.Dom.2-C-terminal))  with  no mutation  in a nonphosphorylated state|A ribosomal protein S6 kinase alpha-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15349] |ribosomal protein s6 kinase alpha-2 (RSK3(Kin.Dom.1-N-terminal))  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300280,,,,,,,,"ribosomal protein s6 kinase alpha-2 (RSK3(Kin.Dom.2-C-terminal))  with  no mutation  in a nonphosphorylated state|A ribosomal protein S6 kinase alpha-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15349] |ribosomal protein s6 kinase alpha-2 (RSK3(Kin.Dom.1-N-terminal))  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100252,,,,https://pharos.nih.gov/idg/targets/Q15349,,,,,,,,,,,,,RPS6KA2,MAPKAPK1C|RSK3,,Q15349,,,,,,,,Ribosomal protein s6 kinase alpha-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200567,"[""OR4A8P gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200567,,,,,,,,,,,,,,,,81315,OR4A8P,OR4A8,,,,,,,,,,OR4A8P gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300192,"[""TKL-UNIQUE family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300107,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300192,,,,,,,,,,,,,,,,,,,,,,,,,,,,TKL-UNIQUE family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400292,"[""ERK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400191,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400292,,,,,,,,,,,,,,,,,,,,,,,,,,,,ERK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400499,"[""Beta-2/CHRNB2 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400499,,,,,,,,,,,,,,,,,,,,,,,,,,,,Beta-2/CHRNB2 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100035,"[""L800 in PIK3CA(I800L)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100035,,,,,,,,,,,,,,,,,,,,,,,,,,,,L800 in PIK3CA(I800L),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060340,"[""ciliopathy""]",,"A genetic disease associated with mutations encoding defective proteins, which result in either abnormal function formation or function of cilia.",false,,,http://purl.obolibrary.org/obo/DOID_630,,,,,,,,"A genetic disease associated with mutations encoding defective proteins, which result in either abnormal function formation or function of cilia.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060340,emitraka,2015-05-21T10:41:29Z,,,,,disease_ontology,,DOID:0060340,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,ciliopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060345,"[""bacillary angiomatosis""]",,"A bartonellosis that has_material_basis_in Bartonella henselae or has_material_basis_in Bartonella quintana. The disease is characterized by the proliferation of blood vessels, resulting in them forming tumour-like masses in the skin and other organs.",false,,,http://purl.obolibrary.org/obo/DOID_11102,,,,,,,,"A bartonellosis that has_material_basis_in Bartonella henselae or has_material_basis_in Bartonella quintana. The disease is characterized by the proliferation of blood vessels, resulting in them forming tumour-like masses in the skin and other organs.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060345,emitraka,2015-05-28T16:26:12Z,,MESH:D016917|NCI:C3477|UMLS_CUI:C0085434|SNOMEDCT_US_2016_03_01:58213005,,,disease_ontology,,DOID:0060345,http://purl.obolibrary.org/obo/doid#GOLD,,,,,,,,,,,,,,,,,,bacillary angiomatosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060344,"[""acrodermatitis chronica atrophicans""]",,"An acrodermatitis characterized by a chronically progressive course, leading to widespread atrophy of the skin. It is a clinical manifestation of Lyme borreliosis.",false,,,http://purl.obolibrary.org/obo/DOID_2722,,,,,,,,"An acrodermatitis characterized by a chronically progressive course, leading to widespread atrophy of the skin. It is a clinical manifestation of Lyme borreliosis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060344,emitraka,2015-05-28T14:45:56Z,,DERMO:0002165|SNOMEDCT_US_2016_03_01:201088002|SNOMEDCT_US_2016_03_01:201079006|ICD9CM:701.8|UMLS_CUI:C0029805,primary diffuse atrophy|Herxheimer disease,,disease_ontology,,DOID:0060344,http://purl.obolibrary.org/obo/doid#GOLD,,,,,,,,,,,,,,,,,,acrodermatitis chronica atrophicans,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000359,"[""THR489 in RSK1(Kin.Dom.2-C-terminal)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000359,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR489 in RSK1(Kin.Dom.2-C-terminal),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100750,"[""Prokineticin receptor 2""]",,"A prokineticin receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8NFJ6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A prokineticin receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8NFJ6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100750,,,,https://pharos.nih.gov/idg/targets/Q8NFJ6,,,,,,,,,,,,,PROKR2,GPR73L1|PKR2,,Q8NFJ6,,,,,,,,Prokineticin receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400240,"[""TTK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400240,,,,,,,,,,,,,,,,,,,,,,,,,,,,TTK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200569,"[""OR4C3 gene""]",,"An olfactory receptor 4C3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH37] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4C3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH37] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200569,,,,,,,,,,,,,,,,256144,OR4C3,,,,,,,,,,,OR4C3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100022,"[""I317 in ABL1(F317I)-phosphorylated""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100022,,,,,,,,,,,,,,,,,,,,,,,,,,,,I317 in ABL1(F317I)-phosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5603,"[""acute T cell leukemia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_715,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5603,,,,MESH:D015459|SNOMEDCT_US_2016_03_01:188729005|ICD10CM:C91.5|ICD10CM:C91.50|NCI:C3184|SNOMEDCT_US_2016_03_01:77430005|CSP:2004-1803|UMLS_CUI:C0023493|CSP:2004-1600|SNOMEDCT_US_2016_03_01:110007008,Precursor T Lymphoblastic Leukemia|T-cell acute lymphoblastic leukemia (disorder),,disease_ontology,,DOID:5603,,,,,,,,,,,,,,,,,,,acute T cell leukemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100792,"[""Taste receptor type 2 member 60""]",,"A taste receptor type 2 member 60 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59551] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300014,,,,,,,,"A taste receptor type 2 member 60 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59551] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100792,,,,https://pharos.nih.gov/idg/targets/P59551,,,,,,,,,,,,,TAS2R60,,,P59551,,,,,,,,Taste receptor type 2 member 60,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003483,"[""sebaceous gland cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003483,,,,,,,BrendaTissueOBO,,BTO:0003483,,,,,,,,,,,,,,,,,,,sebaceous gland cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200068,"[""CDK2 gene""]",,"This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400258,,,,,,,,"This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200068,,,,,,,,,,,,,,,,1017,CDK2,CDKN2,,,,,,,,,,CDK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4195,"[""hyperglycemia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4194,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4195,,,,SNOMEDCT_US_2016_03_01:144187006|MESH:D006943|SNOMEDCT_US_2016_03_01:237598005|SNOMEDCT_US_2016_03_01:315299009|SNOMEDCT_US_2016_03_01:390730002|ICD10CM:R73.9|NCI:C26797|SNOMEDCT_US_2016_03_01:80394007|SNOMEDCT_US_2016_03_01:207289007|SNOMEDCT_US_2016_03_01:154719004|UMLS_CUI:C0020456|SNOMEDCT_US_2016_03_01:207643008|SNOMEDCT_US_2016_03_01:270004003,,,disease_ontology,,DOID:4195,,,,,,,,,,,,,,,,,,,hyperglycemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000934,"[""IMR-32 cell""]",,"Human neuroblastoma, established from an abdominal mass (diagnosed as neuroblastoma) of a 1-year-old caucasian boy in 1967.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000932,,,,,,,,"Human neuroblastoma, established from an abdominal mass (diagnosed as neuroblastoma) of a 1-year-old caucasian boy in 1967.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000934,,,,,,,BrendaTissueOBO,,BTO:0000934,,,,,,,,,,,,,,,,,,,IMR-32 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050471,"[""Carney complex""]",,"An autosomal dominant disease characterized by myxomas, spotty pigmentation of the skin and endocrine overactivity.",false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,"An autosomal dominant disease characterized by myxomas, spotty pigmentation of the skin and endocrine overactivity.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050471,,,,OMIM:605244|SNOMEDCT_US_2016_03_01:239132009|ORDO:1359|MESH:D056733|NCI:C4705|OMIM:160980|UMLS_CUI:C0406810|UMLS_CUI:C1854540|UMLS_CUI:C2607929|OMIM:608837,"Carney complex variant|Carney Complex, Type 1|LAMB Syndrome|NAME Syndrome|Carney Complex, Type 2|Carney Syndrome",,disease_ontology,,DOID:0050471,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,Carney complex,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050472,"[""monilethrix""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050472,,,,NCI:C84894|SNOMEDCT_US_2016_03_01:69488000|SNOMEDCT_US_2016_03_01:276482004|MESH:D056734|SNOMEDCT_US_2016_03_01:205596006|OMIM:158000|ICD10CM:Q84.1|UMLS_CUI:C0546966,,,disease_ontology,,DOID:0050472,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,monilethrix,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050470,"[""Donohue syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050737,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050470,,,,SNOMEDCT_US_2016_03_01:33559001|SNOMEDCT_US_2016_03_01:111307005|NCI:C84676|UMLS_CUI:C0265344|OMIM:246200|MESH:D056731|UMLS_CUI:C0271695,Leprechaunism,,disease_ontology,,DOID:0050470,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Donohue syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050477,"[""Liddle syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_447,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050477,,,,SNOMEDCT_US_2016_03_01:237493003|UMLS_CUI:C0221043|MESH:D056929|SNOMEDCT_US_2016_03_01:190901004|OMIM:177200|SNOMEDCT_US_2016_03_01:707749005|NCI:C84827|SNOMEDCT_US_2016_03_01:71275003,Pseudoaldosteronism|Liddle's syndrome,,disease_ontology,,DOID:0050477,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Liddle syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100037,"[""Voltage-dependent calcium channel subunit alpha-2/delta-4""]",,"A voltage-dependent calcium channel subunit alpha-2/delta-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z3S7] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300332,,,,,,,,"A voltage-dependent calcium channel subunit alpha-2/delta-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z3S7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100037,,,,https://pharos.nih.gov/idg/targets/Q7Z3S7,,,,,,,,,,,,,CACNA2D4,,,Q7Z3S7,,,,,,,,Voltage-dependent calcium channel subunit alpha-2/delta-4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100040,"[""[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial""]",,"A [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14874] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300131,,,,,,,,"A [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14874] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100040,,,,https://pharos.nih.gov/idg/targets/O14874,,,,,,,,,,,,,BCKDK,,,O14874,,,,,,,,"[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400395,"[""ClC-1/CLCN1 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400341,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400395,,,,,,,,,,,,,,,,,,,,,,,,,,,,ClC-1/CLCN1 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000830,"[""mast cell""]",,A large cell that occurs especially in connective tissue and has basophilic granules containing substances (as histamine and heparin) which mediate allergic reactions.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000421,,,,,,,,A large cell that occurs especially in connective tissue and has basophilic granules containing substances (as histamine and heparin) which mediate allergic reactions.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000830,,,,,,,BrendaTissueOBO,labrocyte|mastocyte,BTO:0000830,,,,,,,,,,,,,,,,,,,mast cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200460,"[""OR6C74 gene""]",,"An olfactory receptor 6C74 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NCV1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6C74 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NCV1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200460,,,,,,,,,,,,,,,,254783,OR6C74,,,,,,,,,,,OR6C74 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_7166,"[""thyroiditis""]",,Updating to more specific UMLS_CUI from C0029495 to C0040147.,false,,,http://purl.obolibrary.org/obo/DOID_50,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:7166,,,,SNOMEDCT_US_2016_03_01:154668007|SNOMEDCT_US_2016_03_01:82119001|SNOMEDCT_US_2016_03_01:154664009|ICD9CM:245|MESH:D013966|ICD10CM:E06.9|NCI:C26894|ICD10CM:E06|ICD9CM:245.9|UMLS_CUI:C0040147|SNOMEDCT_US_2016_03_01:190301009,,,disease_ontology,,DOID:7166,,,,,,,,,,,,,,,,,Updating to more specific UMLS_CUI from C0029495 to C0040147.,,thyroiditis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300135,"[""CAMK-UNIQUE family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300135,,,,,,,,,,,,,,,,,,,,,,,,,,,,CAMK-UNIQUE family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001859,"[""wart""]",,A horny projection on the skin usually of the extremities produced by proliferation of the skin papillae and caused by a papillomavirus.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A horny projection on the skin usually of the extremities produced by proliferation of the skin papillae and caused by a papillomavirus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001859,,,,,,,BrendaTissueOBO,verruca vulgaris,BTO:0001859,,,,,,,,,,,,,,,,,,,wart,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000273,"[""ink gland""]",,The ink gland and ink sac are specializations of the rectal gland.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001157,,,,,,,,The ink gland and ink sac are specializations of the rectal gland.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000273,,,,,,,BrendaTissueOBO,,BTO:0000273,,,,,,,,,,,,,,,,,,,ink gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000254,"[""PHE241 in CLK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000254,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE241 in CLK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300040,"[""Free fatty acid receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300040,,,,,,,,,,,,,,,,,,,,,,,,,,,,Free fatty acid receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000275,"[""MK11 kinase domain""]",,Mitogen-activated protein kinase 11; MAPK11; p38-2; p38b; p38Beta; p38-beta; P38BETA2; PRKM11; SAPK2; SAPK2B,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase 11; MAPK11; p38-2; p38b; p38Beta; p38-beta; P38BETA2; PRKM11; SAPK2; SAPK2B,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000275,,,,,,,,,,,,,,,,,,,200299,,,,,,,,,MK11 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100457,"[""Olfactory receptor 6c65""]",,"An olfactory receptor 6C65 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NJZ3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6C65 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NJZ3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100457,,,,https://pharos.nih.gov/idg/targets/A6NJZ3,,,,,,,,,,,,,OR6C65,,,A6NJZ3,,,,,,,,Olfactory receptor 6c65,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004669,"[""finger""]",,"Any of the five terminating members of the hand, a digit of the forelimb.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Any of the five terminating members of the hand, a digit of the forelimb.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004669,mgr,2010-05-10T12:30:15Z,,,,,BrendaTissueOBO,forelimb digit|digit,BTO:0004669,,,,,,,,,,,,,,,,,,,finger,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000173,"[""FRK kinase domain""]",,Tyrosine-protein kinase FRK; Fyn-related kinase; FRK; GTK; PTK5; RAK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Tyrosine-protein kinase FRK; Fyn-related kinase; FRK; GTK; PTK5; RAK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000173,,,,,,,,,,,,,,,,,,,200176,,,,,,,,,FRK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100553,"[""Olfactory receptor 2V1""]",,"An olfactory receptor 2V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHB1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHB1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100553,,,,https://pharos.nih.gov/idg/targets/Q8NHB1,,,,,,,,,,,,,OR2V1,,,Q8NHB1,,,,,,,,Olfactory receptor 2V1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13025,"[""retinopathy of prematurity""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5679,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13025,,,,ICD9CM:362.21|ICD10CM:H35.17|MESH:D012178|SNOMEDCT_US_2016_03_01:74277007|NCI:C34982|ICD10CM:H35.10|ICD9CM:362.20|UMLS_CUI:C0035344|SNOMEDCT_US_2016_03_01:415297005|SNOMEDCT_US_2016_03_01:155110004|ICD10CM:H35.1,premature retinopathy|Retrolental fibroplasia,,disease_ontology,,DOID:13025,,,,,,,,,,,,,,,,,,,retinopathy of prematurity,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002575,"[""IGROV-1 cell""]",,Human ovary carcinoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000811,,,,,,,,Human ovary carcinoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002575,,,,,,,BrendaTissueOBO,IGROV1 cell,BTO:0002575,,,,,,,,,,,,,,,,,,,IGROV-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100579,"[""Olfactory receptor 4D5""]",,"An olfactory receptor 4D5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4D5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100579,,,,https://pharos.nih.gov/idg/targets/Q8NGN0,,,,,,,,,,,,,OR4D5,,,Q8NGN0,,,,,,,,Olfactory receptor 4D5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004059,"[""CCD-18Co cell""]",,Human normal colon fibroblast cell line established from a black 2.5-months-old human female.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000188,,,,,,,,Human normal colon fibroblast cell line established from a black 2.5-months-old human female.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004059,,,,,,,BrendaTissueOBO,,BTO:0004059,,,,,,,,,,,,,,,,,,,CCD-18Co cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00000002,"[""gatekeeper role""]",,Any amino acid residue of the kinase that is annotated as a gatekeeper. A gatekeeper residue is a residue that partially or fully blocks a hydrophobic region deep in the ATP binding pocket of a kinase.,false,,,http://purl.obolibrary.org/obo/BFO_0000023,,,,,,,,Any amino acid residue of the kinase that is annotated as a gatekeeper. A gatekeeper residue is a residue that partially or fully blocks a hydrophobic region deep in the ATP binding pocket of a kinase.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00000002,,,,,,,,,,,,,,,,,,,,,,,,,,,,gatekeeper role,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100212,"[""Potassium voltage-gated channel subfamily H member 8""]",,"A voltage-gated potassium channel KCNH8 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q96L42] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300560,,,,,,,,"A voltage-gated potassium channel KCNH8 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q96L42] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100212,,,,https://pharos.nih.gov/idg/targets/Q96L42,,,,,,,,,,,,,KCNH8,,,Q96L42,,,,,,,,Potassium voltage-gated channel subfamily H member 8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100183,"[""G-protein coupled receptor 20""]",,"A G-protein coupled receptor 20 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99678] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300053,,,,,,,,"A G-protein coupled receptor 20 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99678] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100183,,,,https://pharos.nih.gov/idg/targets/Q99678,,,,,,,,,,,,,GPR20,,,Q99678,,,,,,,,G-protein coupled receptor 20,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200152,"[""FGFR4 gene""]",,"The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400158,,,,,,,,"The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200152,,,,,,,,,,,,,,,,2264,FGFR4,JTK2|TKF,,,,,,,,,,FGFR4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400006,"[""Other 7TM proteins gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400001,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400006,,,,,,,,,,,,,,,,,,,,,,,,,,,,Other 7TM proteins gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100811,"[""Taste receptor type 1 member 2""]",,"A taste receptor type 1 member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TE23] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300015,,,,,,,,"A taste receptor type 1 member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TE23] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100811,,,,https://pharos.nih.gov/idg/targets/Q8TE23,,,,,,,,,,,,,TAS1R2,GPR71|T1R2|TR2,,Q8TE23,,,,,,,,Taste receptor type 1 member 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200210,"[""GPR82 gene""]",,"A G-protein coupled receptor 82 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P67] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400023,,,,,,,,"A G-protein coupled receptor 82 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P67] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200210,,,,,,,,,,,,,,,,27197,GPR82,,,,,,,,,,,GPR82 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000803,"[""pancreatic delta cell""]",,A type of cell in the pancreatic islets that secretes somatostatin.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A type of cell in the pancreatic islets that secretes somatostatin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000803,,,,,,,BrendaTissueOBO,,BTO:0000803,,,,,,,,,,,,,,,,,,,pancreatic delta cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000156,"[""brown adipose tissue""]",,A mammalian heat-producing tissue occurring especially in human newborns and in hibernators.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001487,,,,,,,,A mammalian heat-producing tissue occurring especially in human newborns and in hibernators.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000156,,,,,,,BrendaTissueOBO,brown fat,BTO:0000156,,,,,,,,,,,,,,,,,,,brown adipose tissue,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_17544,"[""Hydrogencarbonate""]","Bicarbonate anion|Carbonate (HCO31-)|Hydrogentrioxocarbonate|hydrogen carbonate|Monohydrogen carbonate|Bicarbonate|bicarbonate|Bicarbonate ion (HCO31-)|Hydrogen carbonate anion|InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1|Carbonic acid|HCO3(-)|Hydrogen carbonate ion (HCO3-)|Carbonate ion (HCO31-)|OC([O-])=O|HCO3-|CHO3|Hydrocarbonate(1-)|Carbonate|Bicarbonate (HCO3-)|Hydrogen carbonate (HCO3-)|Bicarbonate ion|BICARBONATE ION|Hydrogen carbonate ion|[CO2(OH)](-)|BVKZGUZCCUSVTD-UHFFFAOYSA-M|Acid carbonate|Bicarbonate ions","
The carbon oxoanion resulting from the removal of a proton from carbonic acid.
",false,,,http://purl.obolibrary.org/obo/CHEBI_22563,,,,,,,KEGG COMPOUND:C00288|ChemIDplus:71-52-3|Beilstein:3903504|PDBeChem:BCT|HMDB:HMDB00595|MetaCyc:HCO3|CiteXplore:17215880|CiteXplore:4208463|Wikipedia:Bicarbonate|CiteXplore:17505962|Gmelin:49249,"
The carbon oxoanion resulting from the removal of a proton from carbonic acid.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:40961|CHEBI:5589|CHEBI:22863|CHEBI:13363,,hydrogentrioxocarbonate(IV)|Hydrogencarbonate|hydrogencarbonate|hydroxidodioxidocarbonate(1-)|hydrogentrioxocarbonate(1-)|hydrogen(trioxidocarbonate)(1-)|hydrogencarbonate(1-),,chebi_ontology,"Bicarbonate anion|Carbonate (HCO31-)|Hydrogentrioxocarbonate|hydrogen carbonate|Monohydrogen carbonate|Bicarbonate|bicarbonate|Bicarbonate ion (HCO31-)|Hydrogen carbonate anion|InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1|Carbonic acid|HCO3(-)|Hydrogen carbonate ion (HCO3-)|Carbonate ion (HCO31-)|OC([O-])=O|HCO3-|CHO3|Hydrocarbonate(1-)|Carbonate|Bicarbonate (HCO3-)|Hydrogen carbonate (HCO3-)|Bicarbonate ion|BICARBONATE ION|Hydrogen carbonate ion|[CO2(OH)](-)|BVKZGUZCCUSVTD-UHFFFAOYSA-M|Acid carbonate|Bicarbonate ions",,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:17544,,,,,Hydrogencarbonate|hydrogencarbonate,,CHEBI:17544,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300131,"[""PDHK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300108,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300131,,,,,,,,,,,,,,,,,,,,,,,,,,,,PDHK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2064,"[""vulvar syringoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2064,,,,UMLS_CUI:C1520099|NCI:C40311,,,disease_ontology,,DOID:2064,,,,,,,,,,,,,,,,,,,vulvar syringoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100490,"[""Olfactory receptor 1G1""]",,"An olfactory receptor 1G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47890] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47890] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100490,,,,https://pharos.nih.gov/idg/targets/P47890,,,,,,,,,,,,,OR1G1,OR1G2,,P47890,,,,,,,,Olfactory receptor 1G1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03390001,"[""Pseudokinase""]",,A protein containing a catalytically inactive kinase domain.,false,,,http://www.drugtargetontology.org/dto/DTO_03300101,,,,,,,,A protein containing a catalytically inactive kinase domain.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03390001,,,,,,,,,,,,,,,,,,,,,,,,,,,https://en.wiktionary.org/wiki/pseudokinase,Pseudokinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002587,"[""NCI-H295 cell""]",,Pluripotent adrenocortical carcinoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Pluripotent adrenocortical carcinoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002587,,,,,,,BrendaTissueOBO,H-295 cell|H295 cell,BTO:0002587,,,,,,,,,,,,,,,,,,,NCI-H295 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004607,"[""MDCK-2 cell""]",,Cell line was derived by cloning  the parental cell line MDCK.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Cell line was derived by cloning  the parental cell line MDCK.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004607,mgr,2010-04-13T10:58:41Z,,,,,BrendaTissueOBO,MDCK2 cell|MDCK.2 cell|MDCK II cell,BTO:0004607,,,,,,,,,,,,,,,,,,,MDCK-2 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100132,"[""Ephrin type-a receptor 8""]",,"ephrin type-a receptor 8 (EPHA8)  with  no mutation  in a nonphosphorylated state|An ephrin type-A receptor 8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P29322] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300153,,,,,,,,"ephrin type-a receptor 8 (EPHA8)  with  no mutation  in a nonphosphorylated state|An ephrin type-A receptor 8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P29322] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100132,,,,https://pharos.nih.gov/idg/targets/P29322,,,,,,,,,,,,,EPHA8,EEK|HEK3|KIAA1459,,P29322,,,,,,,,Ephrin type-a receptor 8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3012,"[""Li-Fraumeni syndrome""]",,"An autosomal dominant disease characterized by increases risk of developing several types of cancer, including breast cancer, osteosarcomata and soft tissue sarcomata.",false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,"An autosomal dominant disease characterized by increases risk of developing several types of cancer, including breast cancer, osteosarcomata and soft tissue sarcomata.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3012,,,,UMLS_CUI:C0085390|OMIM:609265|NCI:C3476|SNOMEDCT_US_2016_03_01:428850001|MESH:D016864|OMIM:151623|ORDO:524|OMIM:609266,"SBLA syndrome|Li-Fraumeni Familiar cancer Susceptibility syndrome|sarcoma, breast, leukaemia and adrenal gland syndrome",,disease_ontology,,DOID:3012,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,Li-Fraumeni syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200616,"[""PGK2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200616,,,,,,,,,,,,,,,,,,,,,,,,,,,,PGK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200113,"[""DYRK1A gene""]",,"This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400266,,,,,,,,"This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200113,,,,,,,,,,,,,,,,1859,DYRK1A,DYRK|MNB|MNBH,,,,,,,,,,DYRK1A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100773,"[""Somatostatin receptor type 4""]",,"A somatostatin receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P31391] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A somatostatin receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P31391] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100773,,,,https://pharos.nih.gov/idg/targets/P31391,,,,,,,,,,,,,SSTR4,,,P31391,,,,,,,,Somatostatin receptor type 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100093,"[""Casein kinase ii subunit alpha 3""]",,"A protein that is a translation product of the human CSNK2A3 gene. [PRO:DNx, UniProtKB:Q8NEV1] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300142,,,,,,,,"A protein that is a translation product of the human CSNK2A3 gene. [PRO:DNx, UniProtKB:Q8NEV1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100093,,,,https://pharos.nih.gov/idg/targets/Q8NEV1,,,,,,,,,,,,,CSNK2A3,CSNK2A1P,,Q8NEV1,,,,,,,,Casein kinase ii subunit alpha 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200493,"[""STK32C gene""]",,"The protein encoded by this gene is a member of the serine/threonine protein kinase family. The specific function of this kinase is not known. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400227,,,,,,,,"The protein encoded by this gene is a member of the serine/threonine protein kinase family. The specific function of this kinase is not known. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200493,,,,,,,,,,,,,,,,282974,STK32C,YANK3,,,,,,,,,,STK32C gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000331,"[""L-929 cell""]",,"Mouse connective tissue fibroblast, established from the normal subcutaneous areolar and adipose tissue of a male C3H/An mouse; used as target in TNF detection assays.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000453,,,,,,,,"Mouse connective tissue fibroblast, established from the normal subcutaneous areolar and adipose tissue of a male C3H/An mouse; used as target in TNF detection assays.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000331,,,,,,,BrendaTissueOBO,L cell|NCTC clone 929|L929 cell|L-cell,BTO:0000331,,,,,,,,,,,,,,,,,,,L-929 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200497,"[""OR1L3 gene""]",,"An olfactory receptor 1L3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH93] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1L3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH93] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200497,,,,,,,,,,,,,,,,26735,OR1L3,,,,,,,,,,,OR1L3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100354,"[""Serine/threonine-protein kinase nek11""]",,"A serine/threonine-protein kinase Nek11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG66] |serine/threonine-protein kinase nek11 (NEK11)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300197,,,,,,,,"A serine/threonine-protein kinase Nek11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG66] |serine/threonine-protein kinase nek11 (NEK11)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100354,,,,https://pharos.nih.gov/idg/targets/Q8NG66,,,,,,,,,,,,,NEK11,,,Q8NG66,,,,,,,,Serine/threonine-protein kinase nek11,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200114,"[""GABRB2 gene""]",,"The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400513,,,,,,,,"The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200114,,,,,,,,,,,,,,,,2561,GABRB2,,,,,,,,,,,GABRB2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200029,"[""NPR2 gene""]",,"This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400125,,,,,,,,"This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200029,,,,,,,,,,,,,,,,4882,NPR2,ANPRB,,,,,,,,,,NPR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050452,"[""mevalonic aciduria""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_906,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050452,,,,UMLS_CUI:C0398691|NCI:C84890|MESH:D054078|UMLS_CUI:C0342731|SNOMEDCT_US_2016_03_01:234538002|OMIM:610377|UMLS_CUI:C1959626|SNOMEDCT_US_2016_03_01:124327008,Mevalonate Kinase Deficiency,,disease_ontology,,DOID:0050452,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,mevalonic aciduria,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050459,"[""hyperphosphatemia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2485,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050459,,,,NCI:C113750|SNOMEDCT_US_2016_03_01:20165001|UMLS_CUI:C0085681|MESH:D054559,,,disease_ontology,,DOID:0050459,,,,,,,,,,,,,,,,,,,hyperphosphatemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050450,"[""Gitelman syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_447,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050450,,,,OMIM:263800|SNOMEDCT_US_2016_03_01:707756004|UMLS_CUI:C0268450|SNOMEDCT_US_2016_03_01:3188003|NCI:C84730|MESH:D053579,"HYPOMAGNESEMIA-HYPOKALEMIA, PRIMARY RENOTUBULAR, WITH HYPOCALCIURIA",,disease_ontology,,DOID:0050450,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Gitelman syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050453,"[""lissencephaly""]",,A congenital nervous system abnormality characterized by the absence of folds in the cerebral cortex and caused_by defective neuronal migration during the 12th to 24th weeks of gestation.,false,,,http://purl.obolibrary.org/obo/DOID_2490,,,,,,,,A congenital nervous system abnormality characterized by the absence of folds in the cerebral cortex and caused_by defective neuronal migration during the 12th to 24th weeks of gestation.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050453,,,,MESH:D054082|ICD10CM:Q04.3|OMIM:300215|OMIM:611603|ORDO:102009|OMIM:300067|ICD10CM:Q04.8|SNOMEDCT_US_2016_03_01:204036008|OMIM:615191|UMLS_CUI:C0266463|OMIM:614019|SNOMEDCT_US_2016_03_01:23024003|OMIM:607432|UMLS_CUI:C0266483|NCI:C103921,,,disease_ontology,,DOID:0050453,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,lissencephaly,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050454,"[""periventricular nodular heterotopia""]",,A congenital nervous system abnormality characterized by non proper migration of neurons during the early development of the fetal brain.,false,,,http://purl.obolibrary.org/obo/DOID_2490,,,,,,,,A congenital nervous system abnormality characterized by non proper migration of neurons during the early development of the fetal brain.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050454,,,,OMIM:612881|ORDO:98892|UMLS_CUI:C1868720|SNOMEDCT_US_2016_03_01:448227009|OMIM:615544|MESH:D054091|OMIM:608097|OMIM:300049|UMLS_CUI:C1848213|OMIM:608098,periventricular heterotopia,,disease_ontology,,DOID:0050454,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,periventricular nodular heterotopia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050451,"[""Brugada syndrome""]",,A heart conduction disease that is characterized by abnormal electrocardiogram (ECG) findings and an increased risk of sudden cardiac death.,false,,,http://purl.obolibrary.org/obo/DOID_10273,,,,,,,,A heart conduction disease that is characterized by abnormal electrocardiogram (ECG) findings and an increased risk of sudden cardiac death.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050451,,,,MESH:D053840|ICD10CM:I49.8|UMLS_CUI:C1955837|SNOMEDCT_US_2016_03_01:418818005|UMLS_CUI:C1142166|UMLS_CUI:C1721096|NCI:C71059,,,disease_ontology,,DOID:0050451,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Brugada syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100229,"[""Hydroxycarboxylic acid receptor 3""]",,"A hydroxycarboxylic acid receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49019] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300060,,,,,,,,"A hydroxycarboxylic acid receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49019] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100229,,,,https://pharos.nih.gov/idg/targets/P49019,,,,,,,,,,,,,HCAR3,GPR109B|HCA3|HM74B|NIACR2,,P49019,,,,,,,,Hydroxycarboxylic acid receptor 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100207,"[""Potassium voltage-gated channel subfamily H member 3""]",,"A voltage-gated potassium channel KCNH3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9ULD8] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300555,,,,,,,,"A voltage-gated potassium channel KCNH3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9ULD8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100207,,,,https://pharos.nih.gov/idg/targets/Q9ULD8,,,,,,,,,,,,,KCNH3,KIAA1282,,Q9ULD8,,,,,,,,Potassium voltage-gated channel subfamily H member 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100118,"[""Gamma-aminobutyric acid receptor subunit gamma-1""]",,"A gamma-aminobutyric acid receptor subunit gamma-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N1C3] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300517,,,,,,,,"A gamma-aminobutyric acid receptor subunit gamma-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N1C3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100118,,,,https://pharos.nih.gov/idg/targets/Q8N1C3,,,,,,,,,,,,,GABRG1,,,Q8N1C3,,,,,,,,Gamma-aminobutyric acid receptor subunit gamma-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000642,"[""intestinal mucosa""]",,The surface lining of the intestines where the cells absorb nutrients.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000886,,,,,,,,The surface lining of the intestines where the cells absorb nutrients.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000642,,,,,,,BrendaTissueOBO,,BTO:0000642,,,,,,,,,,,,,,,,,,,intestinal mucosa,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200052,"[""BUB1 gene""]",,"This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400134,,,,,,,,"This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200052,,,,,,,,,,,,,,,,699,BUB1,BUB1L,,,,,,,,,,BUB1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200732,"[""P2RY11 gene""]",,"A P2Y purinoceptor 11 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96G91] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400100,,,,,,,,"A P2Y purinoceptor 11 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96G91] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200732,,,,,,,,,,,,,,,,5032,P2RY11,,,,,,,,,,,P2RY11 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400199,"[""SCY1 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400199,,,,,,,,,,,,,,,,,,,,,,,,,,,,SCY1 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400270,"[""EEF2K subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400123,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400270,,,,,,,,,,,,,,,,,,,,,,,,,,,,EEF2K subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100096,"[""Tyrosine-protein kinase csk""]",,"tyrosine-protein kinase csk (CSK)  with  no mutation  in a nonphosphorylated state|A tyrosine-protein kinase CSK that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41240] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300144,,,,,,,,"tyrosine-protein kinase csk (CSK)  with  no mutation  in a nonphosphorylated state|A tyrosine-protein kinase CSK that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41240] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100096,,,,https://pharos.nih.gov/idg/targets/P41240,,,,,,,,,,,,,CSK,,,P41240,,,,,,,,Tyrosine-protein kinase csk,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003640,"[""esophageal cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003640,,,,,,,BrendaTissueOBO,,BTO:0003640,,,,,,,,,,,,,,,,,,,esophageal cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100108,"[""Diacylglycerol kinase eta""]",,"A diacylglycerol kinase eta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86XP1] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391025,,,,,,,,"A diacylglycerol kinase eta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86XP1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100108,,,,https://pharos.nih.gov/idg/targets/Q86XP1,,,,,,,,,,,,,DGKH,,,Q86XP1,,,,,,,,Diacylglycerol kinase eta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000044,"[""HCG""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000044,,,,,,,,,,,,,,,,,,,,,,,,,,,,HCG,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000933,"[""N18TG2 cell""]",,Mouse neuroblastoma 6-thioguanine resistant mutant of cell line N18 that was established from a mouse of strain A/Jax with neuroblastoma C1300; cells were described to form cAMP in response to prostaglandin E1 and to be aneuploid (modal chromosome number of 81).,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000932,,,,,,,,Mouse neuroblastoma 6-thioguanine resistant mutant of cell line N18 that was established from a mouse of strain A/Jax with neuroblastoma C1300; cells were described to form cAMP in response to prostaglandin E1 and to be aneuploid (modal chromosome number of 81).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000933,,,,,,,BrendaTissueOBO,,BTO:0000933,,,,,,,,,,,,,,,,,,,N18TG2 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200263,"[""MRGPRX3 gene""]",,"A mas-related G-protein coupled receptor X3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96LB0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400063,,,,,,,,"A mas-related G-protein coupled receptor X3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96LB0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200263,,,,,,,,,,,,,,,,117195,MRGPRX3,MRGX3|SNSR1|SNSR2,,,,,,,,,,MRGPRX3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400068,"[""Neuropeptide W/neuropeptide B receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400068,,,,,,,,,,,,,,,,,,,,,,,,,,,,Neuropeptide W/neuropeptide B receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2717,"[""Bloom syndrome""]",,"An autosomal recessive disease characterized by sun sensitivity, short stature, predisposition to the development of cancer and genomic instability.",false,,,http://purl.obolibrary.org/obo/DOID_0050737,,,,,,,,"An autosomal recessive disease characterized by sun sensitivity, short stature, predisposition to the development of cancer and genomic instability.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2717,,,,ORDO:125|UMLS_CUI:C0005859|NCI:C2903|OMIM:210900|SNOMEDCT_US_2016_03_01:4434006|MESH:D001816,Bloom-Torre-Machacek syndrome|Congenital Telangiectatic Erythema syndrome,,disease_ontology,,DOID:2717,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Bloom syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11665,"[""Patau syndrome""]",,OMIM mapping confirmed by DO. [LS].,false,,,http://purl.obolibrary.org/obo/DOID_0080014,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11665,,,,SNOMEDCT_US_2016_03_01:205622008|UMLS_CUI:C0152095|ICD9CM:758.1|SNOMEDCT_US_2016_03_01:21111006|NCI:C101223|SNOMEDCT_US_2016_03_01:156995003|MESH:C536305|ICD10CM:Q91.7|SNOMEDCT_US_2016_03_01:157021007|SNOMEDCT_US_2016_03_01:268344000|SNOMEDCT_US_2016_03_01:254267009|SNOMEDCT_US_2016_03_01:268357008,trisomy 13|D1 Trisomy ,,disease_ontology,Patau's syndrome,DOID:11665,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,Patau syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400419,"[""GRIK4 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400419,,,,,,,,,,,,,,,,,,,,,,,,,,,,GRIK4 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200250,"[""PKM gene""]",,"This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400324,,,,,,,,"This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200250,,,,,,,,,,,,,,,,5315,PKM,OIP3|PK2|PK3,,,,,,,,,,PKM gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300394,"[""CLCNKB subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300341,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300394,,,,,,,,,,,,,,,,,,,,,,,,,,,,CLCNKB subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100058,"[""Cyclin-dependent kinase 12""]",,"A cyclin-dependent kinase 12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYV4] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300136,,,,,,,,"A cyclin-dependent kinase 12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYV4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100058,,,,https://pharos.nih.gov/idg/targets/Q9NYV4,,,,,,,,,,,,,CDK12,CRK7|CRKRS|KIAA0904,,Q9NYV4,,,,,,,,Cyclin-dependent kinase 12,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000093,"[""SDF-1 beta""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000093,,,,,,,,,,,,,,,,,,,,,,,,,,,,SDF-1 beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400029,"[""Calcium-sensing receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400004,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400029,,,,,,,,,,,,,,,,,,,,,,,,,,,,Calcium-sensing receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000218,"[""KIT(L576P) kinase domain""]",,V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; C-Kit; KIT; PBT; SCFR,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; C-Kit; KIT; PBT; SCFR,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000218,,,,,,,,,,,,,,,,,,,200218,,,,,,,,,KIT(L576P) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200307,"[""TMEM38A gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400371,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200307,,,,,,,,,,,,,,,,79041,TMEM38A,,,,,,,,,,,TMEM38A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100248,"[""Leucine-rich repeat-containing protein 55""]",,"A leucine-rich repeat-containing protein 55 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6ZSA7] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,"A leucine-rich repeat-containing protein 55 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6ZSA7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100248,,,,https://pharos.nih.gov/idg/targets/Q6ZSA7,,,,,,,,,,,,,LRRC55,,,Q6ZSA7,,,,,,,,Leucine-rich repeat-containing protein 55,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100065,"[""Calcium-activated chloride channel regulator 1""]",,"A calcium-activated chloride channel regulator 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A8K7I4] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300339,,,,,,,,"A calcium-activated chloride channel regulator 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A8K7I4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100065,,,,https://pharos.nih.gov/idg/targets/A8K7I4,,,,,,,,,,,,,CLCA1,CACC1,,A8K7I4,,,,,,,,Calcium-activated chloride channel regulator 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100583,"[""Glycerate kinase""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100583,,,,,,,,,,,,,,,,,GLYCTK,,,Q8IVS8,,,,,,,,Glycerate kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100380,"[""Phosphatidylinositol 4-phosphate 3-kinase c2 domain-containing subunit gamma""]",,"phosphatidylinositol 4-phosphate 3-kinase c2 domain-containing subunit gamma (PIK3C2G)  with  no mutation  in a nonphosphorylated state|A phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75747] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391009,,,,,,,,"phosphatidylinositol 4-phosphate 3-kinase c2 domain-containing subunit gamma (PIK3C2G)  with  no mutation  in a nonphosphorylated state|A phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75747] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100380,,,,https://pharos.nih.gov/idg/targets/O75747,,,,,,,,,,,,,PIK3C2G,,,O75747,,,,,,,,Phosphatidylinositol 4-phosphate 3-kinase c2 domain-containing subunit gamma,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060250,"[""idiopathic scoliosis""]",,A scoliosis with no known cause.,false,,,http://purl.obolibrary.org/obo/DOID_0060249,,,,,,,,A scoliosis with no known cause.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060250,emitraka,2015-01-29T15:52:18Z,,OMIM:181800|OMIM:612239|OMIM:607354|OMIM:608765|OMIM:612238,,,disease_ontology,,DOID:0060250,,,,,,,,,,,,,,,,,NT MGI.,,idiopathic scoliosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060256,"[""Dowling-Degos disease""]",,"A pigmentation disease characterized by a reticulate pattern of abnormally dark skin coloring, particularly in the body's folds and creases.",false,,,http://purl.obolibrary.org/obo/DOID_10123,,,,,,,,"A pigmentation disease characterized by a reticulate pattern of abnormally dark skin coloring, particularly in the body's folds and creases.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060256,emitraka,2015-01-30T11:04:57Z,,OMIM:615696|UMLS_CUI:C0406811|OMIM:179850|MESH:C562924|UMLS_CUI:C3714534|ORDO:79145|OMIM:615674|SNOMEDCT_US_2016_03_01:239133004|OMIM:615327,dark dot disease|reticular pigment anomaly of flexures,,disease_ontology,,DOID:0060256,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,NT MGI.,,Dowling-Degos disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060254,"[""Robinow syndrome""]",,"A syndrome characterized by mild to moderate short stature due to growth delays after birth, distinctive craniofacial abnormalities, skeletal malformations and genital abnormalities.",false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,"A syndrome characterized by mild to moderate short stature due to growth delays after birth, distinctive craniofacial abnormalities, skeletal malformations and genital abnormalities.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060254,emitraka,2015-01-29T16:42:52Z,,MESH:C562492|ICD10CM:Q87.1|SNOMEDCT_US_2016_03_01:76520005|ORDO:97360|NCI:C85048|UMLS_CUI:C0265205,acral dysostosis with facial and genital abnormalities|Robinow dwarfism|fetal face syndrome,,disease_ontology,,DOID:0060254,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,NT MGI.,,Robinow syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060255,"[""rippling muscle disease 2""]",,"A muscle tissue disease characterized by muscles unusually sensitive to movement or pressure; the proximal muscles are most affected, especially the thighs.",false,,,http://purl.obolibrary.org/obo/DOID_66,,,,,,,,"A muscle tissue disease characterized by muscles unusually sensitive to movement or pressure; the proximal muscles are most affected, especially the thighs.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060255,emitraka,2015-01-29T16:51:43Z,,ORDO:97238|OMIM:600332|UMLS_CUI:C1853698|OMIM:606072,,,disease_ontology,,DOID:0060255,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,NT MGI.,,rippling muscle disease 2,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060259,"[""renal-hepatic-pancreatic dysplasia""]",,"A physical disorder characterized by pancreatic fibrosis, renal dysplasia and hepatic dysgenesis; it is usual fatal soon after birth.",false,,,http://purl.obolibrary.org/obo/DOID_0080015,,,,,,,,"A physical disorder characterized by pancreatic fibrosis, renal dysplasia and hepatic dysgenesis; it is usual fatal soon after birth.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060259,emitraka,2015-01-30T16:33:37Z,,OMIM:615415|ORDO:294415|OMIM:208540,Ivemark's syndrome,,disease_ontology,,DOID:0060259,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,renal-hepatic-pancreatic dysplasia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200791,"[""TAS2R50 gene""]",,"A taste receptor type 2 member 50 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59544] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400014,,,,,,,,"A taste receptor type 2 member 50 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59544] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200791,,,,,,,,,,,,,,,,259296,TAS2R50,,,,,,,,,,,TAS2R50 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400132,"[""SRC family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400132,,,,,,,,,,,,,,,,,,,,,,,,,,,,SRC family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300048,"[""Ghrelin receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300048,,,,,,,,,,,,,,,,,,,,,,,,,,,,Ghrelin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200343,"[""PKD1L1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200343,,,,,,,,,,,,,,,,,PKD1L1,,,,,,,,,,,PKD1L1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200024,"[""ALPK2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400123,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200024,,,,,,,,,,,,,,,,115701,ALPK2,HAK,,,,,,,,,,ALPK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3717,"[""gastric adenocarcinoma""]",,A stomach carcinoma that derives_from epithelial cells of glandular origin.,false,,,http://purl.obolibrary.org/obo/DOID_5517|http://purl.obolibrary.org/obo/DOID_299,,,,,,,,A stomach carcinoma that derives_from epithelial cells of glandular origin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3717,,,,UMLS_CUI:C0278701|SNOMEDCT_US_2016_03_01:408647009|NCI:C4004,adenocarcinoma of stomach (disorder)|stomach adenocarcinoma,,disease_ontology,,DOID:3717,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,gastric adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100009,"[""5-hydroxytryptamine receptor 4""]",,"A 5-hydroxytryptamine receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13639] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302003,,,,,,,,"A 5-hydroxytryptamine receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13639] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100009,,,,https://pharos.nih.gov/idg/targets/Q13639,,,,,,,,,,,,,HTR4,,,Q13639,,,,,,,,5-hydroxytryptamine receptor 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200025,"[""CHRM5 gene""]",,"A muscarinic acetylcholine receptor M5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08912] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400020,,,,,,,,"A muscarinic acetylcholine receptor M5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08912] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200025,,,,,,,,,,,,,,,,1133,CHRM5,,,,,,,,,,,CHRM5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200235,"[""LGR4 gene""]",,"A leucine-rich repeat-containing G-protein coupled receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BXB1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A leucine-rich repeat-containing G-protein coupled receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BXB1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200235,,,,,,,,,,,,,,,,55366,LGR4,GPR48,,,,,,,,,,LGR4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200223,"[""GRM6 gene""]",,"A metabotropic glutamate receptor 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15303] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400059,,,,,,,,"A metabotropic glutamate receptor 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15303] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200223,,,,,,,,,,,,,,,,2916,GRM6,GPRC1F|MGLUR6,,,,,,,,,,GRM6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000042,"[""LEU1196 in ALK(C1156Y)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000042,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU1196 in ALK(C1156Y),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100739,"[""Proteinase-activated receptor 3""]",,"A proteinase-activated receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00254] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300079,,,,,,,,"A proteinase-activated receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00254] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100739,,,,https://pharos.nih.gov/idg/targets/O00254,,,,,,,,,,,,,F2RL2,PAR3,,O00254,,,,,,,,Proteinase-activated receptor 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100012,"[""Neuronal acetylcholine receptor subunit alpha-7""]",,"A neuronal acetylcholine receptor subunit alpha-7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P36544] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300496,,,,,,,,"A neuronal acetylcholine receptor subunit alpha-7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P36544] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100012,,,,https://pharos.nih.gov/idg/targets/P36544,,,,,,,,,,,,,CHRNA7,CHRFAM7A|NACHRA7,,P36544,,,,,,,,Neuronal acetylcholine receptor subunit alpha-7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200193,"[""GPR35 gene""]",,"A G-protein coupled receptor 35 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HC97] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 35 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HC97] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200193,,,,,,,,,,,,,,,,2859,GPR35,,,,,,,,,,,GPR35 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200194,"[""ITK gene""]",,"This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400133,,,,,,,,"This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200194,,,,,,,,,,,,,,,,3702,ITK,EMT|LYK,,,,,,,,,,ITK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004253,"[""plant candle""]",,The new vegetative growth of Pinus taeda plants in the center surrounded by young male cones. This young growth is called a candle and will expand into stem and needles.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001243,,,,,,,,The new vegetative growth of Pinus taeda plants in the center surrounded by young male cones. This young growth is called a candle and will expand into stem and needles.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004253,,,,,,,BrendaTissueOBO,candle,BTO:0004253,,,,,,,,,,,,,,,,,,,plant candle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100134,"[""Adhesion G protein-coupled receptor F4""]",,"A G-protein coupled receptor 115 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,"A G-protein coupled receptor 115 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100134,,,,https://pharos.nih.gov/idg/targets/Q8IZF3,,,,,,,,,,,,,GPR115,ADGRF4|PGR18,,Q8IZF3,,,,,,,,Adhesion G protein-coupled receptor F4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400026,"[""Bombesin receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400026,,,,,,,,,,,,,,,,,,,,,,,,,,,,Bombesin receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003021,"[""NCI-H187 cell""]",,Small cell lung cancer cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002206,,,,,,,,Small cell lung cancer cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003021,,,,,,,BrendaTissueOBO,H-187 cell|H187 cell,BTO:0003021,,,,,,,,,,,,,,,,,,,NCI-H187 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200400,"[""PDPK2P gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400102,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200400,,,,,,,,,,,,,,,,653650,PDPK2P,PDPK2,,,,,,,,,,PDPK2P gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000849,"[""melanoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000849,,,,,,,BrendaTissueOBO,,BTO:0000849,,,,,,,,,,,,,,,,,,,melanoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200085,"[""DRD5 gene""]",,"A D(1B) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21918] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400037,,,,,,,,"A D(1B) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21918] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200085,,,,,,,,,,,,,,,,1816,DRD5,DRD1B|DRD1L2,,,,,,,,,,DRD5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000323,"[""THR309 in BMPR1A""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000323,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR309 in BMPR1A,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300307,"[""PDK1 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300203,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300307,,,,,,,,,,,,,,,,,,,,,,,,,,,,PDK1 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200450,"[""OR5AN1 gene""]",,"An olfactory receptor 5AN1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5AN1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200450,,,,,,,,,,,,,,,,390195,OR5AN1,,,,,,,,,,,OR5AN1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200545,"[""TTBK1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400239,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200545,,,,,,,,,,,,,,,,84630,TTBK1,BDTK|KIAA1855,,,,,,,,,,TTBK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14793,"[""hypohidrotic ectodermal dysplasia""]",,"A monogenic disease that is characterized by malformation of ectodermal (skin, hair, teeth and sweat glands) structures including hypotrichosis (sparseness of scalp and body hair), hypohidrosis (reduced ability to sweat), and hypodontia (congenital absence of teeth).",false,,,http://purl.obolibrary.org/obo/DOID_14693,,,,,,,,"A monogenic disease that is characterized by malformation of ectodermal (skin, hair, teeth and sweat glands) structures including hypotrichosis (sparseness of scalp and body hair), hypohidrosis (reduced ability to sweat), and hypodontia (congenital absence of teeth).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14793,,,DOID:0050446|DOID:0050447,SNOMEDCT_US_2016_03_01:4826006|OMIM:300291|MESH:D053358|UMLS_CUI:C0162359|OMIM:305100|OMIM:224900|SNOMEDCT_US_2016_03_01:239007005|NCI:C84562|OMIM:129490|SNOMEDCT_US_2016_03_01:7731005,"Christ-Siemens-Touraine Syndrome|anhidrotic ectodermal dysplasia 3|Ectodermal Dysplasia 1, Anhydrotic|Hypohidrotic X-linked ectodermal dysplasia (disorder)",,disease_ontology,,DOID:14793,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,hypohidrotic ectodermal dysplasia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14791,"[""Leber congenital amaurosis""]",,"A retinal disease that is characterized by nystagmus, sluggish or no pupillary responses, and severe vision loss or blindness.",false,,,http://purl.obolibrary.org/obo/DOID_5679,,,,,,,,"A retinal disease that is characterized by nystagmus, sluggish or no pupillary responses, and severe vision loss or blindness.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14791,,,,OMIM:PS204000|MESH:D057130|ORDO:65|SNOMEDCT_US_2016_03_01:193413001|UMLS_CUI:C0339527,Leber's disease|Leber's amaurosis|LCA|Leber's congenital amaurosis,,disease_ontology,,DOID:14791,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,Leber congenital amaurosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002666,"[""adult stem cell""]",,"Adult stem cells are undifferentiated cells that reproduce daily to provide certain specialized cells. Until recently it was thought that each of these cells could produce just one particular type of cell. This is called differentiation. However in the past few years, evidence has been gathered of stem cells that can transform into several different forms.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Adult stem cells are undifferentiated cells that reproduce daily to provide certain specialized cells. Until recently it was thought that each of these cells could produce just one particular type of cell. This is called differentiation. However in the past few years, evidence has been gathered of stem cells that can transform into several different forms.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002666,,,,,,,BrendaTissueOBO,multipotent adult progenitor cell|adulte Stammzelle|somatic stem cell,BTO:0002666,,,,,,,,,,,,,,,,,,,adult stem cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003728,"[""TXM-13 cell""]",,Human melanoma cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0000849|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human melanoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003728,,,,,,,BrendaTissueOBO,TXM13 cell,BTO:0003728,,,,,,,,,,,,,,,,,,,TXM-13 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100495,"[""Olfactory receptor 1K1""]",,"An olfactory receptor 1K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100495,,,,https://pharos.nih.gov/idg/targets/Q8NGR3,,,,,,,,,,,,,OR1K1,,,Q8NGR3,,,,,,,,Olfactory receptor 1K1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200803,"[""TAAR3 gene""]",,"A trace amine-associated receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9P1P4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A trace amine-associated receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9P1P4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200803,,,,,,,,,,,,,,,,9288,TAAR3,GPR57,,,,,,,,,,TAAR3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1414,"[""ovarian dysfunction""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1100,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1414,,,,ICD9CM:256.39|SNOMEDCT_US_2016_03_01:267399006|ICD9CM:256.3|SNOMEDCT_US_2016_03_01:190543001|SNOMEDCT_US_2016_03_01:190548005|UMLS_CUI:C0029697,,,disease_ontology,,DOID:1414,,,,,,,,,,,,,,,,,,,ovarian dysfunction,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14146,"[""ureterolithiasis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1426,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14146,,,,UMLS_CUI:C0041952|SNOMEDCT_US_2016_03_01:95573009|MESH:D053039|NCI:C114696|ICD9CM:592.1|SNOMEDCT_US_2016_03_01:31054009,Ureteric calculus|Ureteric stone|calculus of ureter,,disease_ontology,,DOID:14146,,,,,,,,,,,,,,,,,,,ureterolithiasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200207,"[""KCNH3 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400555,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200207,,,,,,,,,,,,,,,,23416,KCNH3,KIAA1282,,,,,,,,,,KCNH3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004271,"[""hyalocyte""]",,A cell occurring in the peripheral part of the vitreous body that may be responsible for production of hyaluronic acid and possibly of collagen.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A cell occurring in the peripheral part of the vitreous body that may be responsible for production of hyaluronic acid and possibly of collagen.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004271,,,,,,,BrendaTissueOBO,vitreous cell,BTO:0004271,,,,,,,,,,,,,,,,,,,hyalocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100326,"[""Transient receptor potential cation channel subfamily m member 1""]",,"A transient receptor potential cation channel subfamily M member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z4N2] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300583,,,,,,,,"A transient receptor potential cation channel subfamily M member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z4N2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100326,,,,https://pharos.nih.gov/idg/targets/Q7Z4N2,,,,,,,,,,,,,TRPM1,LTRPC1|MLSN|MLSN1,,Q7Z4N2,,,,,,,,Transient receptor potential cation channel subfamily m member 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100078,"[""C-x-c chemokine receptor type 4""]",,"A C-X-C chemokine receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P61073] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300097,,,,,,,,"A C-X-C chemokine receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P61073] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100078,,,,https://pharos.nih.gov/idg/targets/P61073,,,,,,,,,,,,,CXCR4,,,P61073,,,,,,,,C-x-c chemokine receptor type 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100733,"[""P2y purinoceptor 12""]",,"A P2Y purinoceptor 12 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H244] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300100,,,,,,,,"A P2Y purinoceptor 12 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H244] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100733,,,,https://pharos.nih.gov/idg/targets/Q9H244,,,,,,,,,,,,,P2RY12,HORK3,,Q9H244,,,,,,,,P2y purinoceptor 12,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100210,"[""Casein kinase i isoform epsilon""]",,"casein kinase i isoform epsilon (CSNK1E)  with  no mutation  in a nonphosphorylated state|A casein kinase I isoform epsilon that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49674] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300170,,,,,,,,"casein kinase i isoform epsilon (CSNK1E)  with  no mutation  in a nonphosphorylated state|A casein kinase I isoform epsilon that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49674] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100210,,,,https://pharos.nih.gov/idg/targets/P49674,,,,,,,,,,,,,CSNK1E,,,P49674,,,,,,,,Casein kinase i isoform epsilon,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117464,"[""Retinoic acid-related orphans""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00102000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117464,,,,,,,,,,,,,,,,,,,,,,,,,,,,Retinoic acid-related orphans,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100552,"[""Olfactory receptor 2t8""]",,"An olfactory receptor 2T8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NH00] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2T8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NH00] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100552,,,,https://pharos.nih.gov/idg/targets/A6NH00,,,,,,,,,,,,,OR2T8,OR2T8P,,A6NH00,,,,,,,,Olfactory receptor 2t8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400067,"[""Neuromedin U receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400067,,,,,,,,,,,,,,,,,,,,,,,,,,,,Neuromedin U receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003803,"[""serous adenocarcinoma cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0000167|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003803,,,,,,,BrendaTissueOBO,,BTO:0003803,,,,,,,,,,,,,,,,,,,serous adenocarcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2768,"[""transient tic disorder""]",,"A tic disorder that consists of multiple motor and/or phonic tics with duration of at least 4 weeks, but less than 12 months.",false,,,http://purl.obolibrary.org/obo/DOID_2769,,,,,,,,"A tic disorder that consists of multiple motor and/or phonic tics with duration of at least 4 weeks, but less than 12 months.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2768,,,,SNOMEDCT_US_2016_03_01:192622000|SNOMEDCT_US_2016_03_01:56573006|NCI:C116767|UMLS_CUI:C0040702|ICD10CM:F95.0|MESH:D013981|ICD9CM:307.21,,,disease_ontology,,DOID:2768,,,,,,,,,,,,,,,,,,,transient tic disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4664,"[""filamentary keratitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4677,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4664,,,,SNOMEDCT_US_2016_03_01:51286002|UMLS_CUI:C0155077|ICD9CM:370.23|ICD10CM:H16.12,,,disease_ontology,,DOID:4664,,,,,,,,,,,,,,,,,,,filamentary keratitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_15729,"[""L-ornithine""]","AHLPHDHHMVZTML-BYPYZUCNSA-N|(S)-2,5-Diaminopentanoic acid|132.16106|(S)-2,5-Diaminopentanoate|(S)-2,5-diaminovaleric acid|NCCC[C@H](N)C(O)=O|132.090|C5H12N2O2|0|(S)-alpha,delta-diaminovaleric acid|(S)-ornithine|InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)/t4-/m0/s1",An optically active form of ornithine having L-configuration.,false,,,http://purl.obolibrary.org/obo/CHEBI_33709,,,,,,,PMID:19083482|KEGG:D08302|Gmelin:327282|KEGG:C00077|PMID:22387109|DrugBank:DB00129|CAS:70-26-8|Wikipedia:Ornithine|Reaxys:1722298|PMID:22133808|PMID:18676473|PMID:22735334|Beilstein:1722298|PMID:22033378|PDBeChem:ORN|PMID:19173225|PMID:17190852|HMDB:HMDB00214|KNApSAcK:C00001384|Drug_Central:3401|MetaCyc:ORNITHINE|PMID:15576628,An optically active form of ornithine having L-configuration.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:13148|CHEBI:21367|CHEBI:6280,,"L-Ornithine|L-ornithine|(2S)-2,5-diaminopentanoic acid",,chebi_ontology,"AHLPHDHHMVZTML-BYPYZUCNSA-N|(S)-2,5-Diaminopentanoic acid|132.16106|(S)-2,5-Diaminopentanoate|(S)-2,5-diaminovaleric acid|NCCC[C@H](N)C(O)=O|132.090|C5H12N2O2|0|(S)-alpha,delta-diaminovaleric acid|(S)-ornithine|InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)/t4-/m0/s1",,,CHEBI:15729,,,,,,,,,,,,,,,,,,,,,,,CHEBI:15729,,,,,L-ornithine,,CHEBI:15729,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100208,"[""Potassium voltage-gated channel subfamily H member 4""]",,"A voltage-gated potassium channel KCNH4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9UQ05] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300556,,,,,,,,"A voltage-gated potassium channel KCNH4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9UQ05] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100208,,,,https://pharos.nih.gov/idg/targets/Q9UQ05,,,,,,,,,,,,,KCNH4,,,Q9UQ05,,,,,,,,Potassium voltage-gated channel subfamily H member 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060084,"[""cell type benign neoplasm""]",,A benign neoplasm that is classified by the type of cell or tissue from which it is derived.,false,,,http://purl.obolibrary.org/obo/DOID_0060072,,,,,,,,A benign neoplasm that is classified by the type of cell or tissue from which it is derived.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060084,lschriml,2011-07-14T11:59:48Z,,,,,disease_ontology,,DOID:0060084,,,,,,,,,,,,,,,,,,,cell type benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060087,"[""male reproductive organ benign neoplasm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0050622,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060087,lschriml,2011-07-14T12:20:52Z,,,,,disease_ontology,,DOID:0060087,,,,,,,,,,,,,,,,,,,male reproductive organ benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060085,"[""organ system benign neoplasm""]",,A benign neoplasm that is classified by the organ system from which it is arising from.,false,,,http://purl.obolibrary.org/obo/DOID_0060072,,,,,,,,A benign neoplasm that is classified by the organ system from which it is arising from.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060085,lschriml,2011-07-14T12:12:23Z,,,,,disease_ontology,,DOID:0060085,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,organ system benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060083,"[""immune system cancer""]",,An organ system cancer located_in the immune system that is characterized by uncontrolled cellular proliferation in organs of the immune system.,false,,,http://purl.obolibrary.org/obo/DOID_0050686|http://purl.obolibrary.org/obo/DOID_2914,,,,,,,,An organ system cancer located_in the immune system that is characterized by uncontrolled cellular proliferation in organs of the immune system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060083,lschriml,2011-06-08T01:11:18Z,,,,,disease_ontology,,DOID:0060083,,,,,,,,,,,,,,,,,,,immune system cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060082,"[""breast benign neoplasm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060097|http://purl.obolibrary.org/obo/DOID_3463,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060082,lschriml,2011-06-08T01:02:29Z,,,,,disease_ontology,,DOID:0060082,,,,,,,,,,,,,,,,,,,breast benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060086,"[""female reproductive organ benign neoplasm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0050622,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060086,lschriml,2011-07-14T12:20:52Z,,,,,disease_ontology,,DOID:0060086,,,,,,,,,,,,,,,,,,,female reproductive organ benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060089,"[""endocrine organ benign neoplasm""]",,An organ system benign neoplasm that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.,false,,,http://purl.obolibrary.org/obo/DOID_0060085,,,,,,,,An organ system benign neoplasm that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060089,lschriml,2011-07-14T01:45:15Z,,,,,disease_ontology,,DOID:0060089,,,,,,,,,,,,,,,,,,,endocrine organ benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000290,"[""PHE90 in CAMK2B""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000290,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE90 in CAMK2B,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100295,"[""Sodium channel protein type 4 subunit alpha""]",,"A sodium channel type 4 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35499] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300469,,,,,,,,"A sodium channel type 4 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35499] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100295,,,,https://pharos.nih.gov/idg/targets/P35499,,,,,,,,,,,,,SCN4A,,,P35499,,,,,,,,Sodium channel protein type 4 subunit alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9159,"[""gas gangrene""]",,"A commensal bacterial infectious disease that results_in infection, located_in muscle tissue, has_material_basis_in Clostridium perfringens, which produce gas that becomes trapped in the infected tissue. Gas gangrene usually develops after injuries or surgery. The infection has_symptom large blisters, has_symptom pain in the infected area, has_symptom myonecrosis, has_symptom gas production, and has_symptom sepsis.",false,,,http://purl.obolibrary.org/obo/DOID_37|http://purl.obolibrary.org/obo/DOID_0050339,,,,,,,,"A commensal bacterial infectious disease that results_in infection, located_in muscle tissue, has_material_basis_in Clostridium perfringens, which produce gas that becomes trapped in the infected tissue. Gas gangrene usually develops after injuries or surgery. The infection has_symptom large blisters, has_symptom pain in the infected area, has_symptom myonecrosis, has_symptom gas production, and has_symptom sepsis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9159,,,,SNOMEDCT_US_2016_03_01:276198000|ICD9CM:040.0|UMLS_CUI:C0017105|SNOMEDCT_US_2016_03_01:186407003|ICD10CM:A48.0|SNOMEDCT_US_2016_03_01:186413007|MESH:D005738|SNOMEDCT_US_2016_03_01:80466000,Gas gangrene|Myonecrosis|Gas bacillus infection,,disease_ontology,,DOID:9159,http://purl.obolibrary.org/obo/doid#gram-positive_bacterial_infectious_disease,,,,,,,,,,,,,,,,,,gas gangrene,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100324,"[""Mitogen-activated protein kinase 12""]",,"A mitogen-activated protein kinase 12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P53778] |mitogen-activated protein kinase 12 (MK12)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300294,,,,,,,,"A mitogen-activated protein kinase 12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P53778] |mitogen-activated protein kinase 12 (MK12)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100324,,,,https://pharos.nih.gov/idg/targets/P53778,,,,,,,,,,,,,MAPK12,ERK6|SAPK3,,P53778,,,,,,,,Mitogen-activated protein kinase 12,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100429,"[""Olfactory receptor 52M1""]",,"An olfactory receptor 52M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 52M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100429,,,,https://pharos.nih.gov/idg/targets/Q8NGK5,,,,,,,,,,,,,OR52M1,OR52M1P,,Q8NGK5,,,,,,,,Olfactory receptor 52M1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300113,"[""STE group""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300102,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300113,,,,,,,,,,,,,,,,,,,,,,,,,,,,STE group,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14177,"[""congenital hypogammaglobulinemia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2115,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14177,,,,UMLS_CUI:C1457897|SNOMEDCT_US_2016_03_01:267460002|ICD9CM:279.04|SNOMEDCT_US_2016_03_01:190983003,Congenital hypogammaglobulinaemia|Congenital hypogammaglobulinemia (finding),,disease_ontology,,DOID:14177,,,,,,,,,,,,,,,,,,,congenital hypogammaglobulinemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14174,"[""central neurocytoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3541,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14174,,,,UMLS_CUI:C0206719|NCI:C3791|SNOMEDCT_US_2016_03_01:302832007|MESH:D018306|SNOMEDCT_US_2016_03_01:128858006,Neurolipocytoma,,disease_ontology,,DOID:14174,,,,,,,,,,,,,,,,,,,central neurocytoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2272,"[""vulvovaginal candidiasis""]",,"A candidiasis that involves fungal infection of the vaginal mucous membranes in women caused by Candida albicans. The symptoms include intense vulval pruritus, burning, erythema and dyspareunia associated with a creamy white, curd-like discharge.",false,,,http://purl.obolibrary.org/obo/DOID_37|http://purl.obolibrary.org/obo/DOID_1508,,,,,,,,"A candidiasis that involves fungal infection of the vaginal mucous membranes in women caused by Candida albicans. The symptoms include intense vulval pruritus, burning, erythema and dyspareunia associated with a creamy white, curd-like discharge.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2272,,,,ICD10CM:B37.3|SNOMEDCT_US_2016_03_01:72605008|UMLS_CUI:C0700345|SNOMEDCT_US_2016_03_01:266155003|NCI:C2914|SNOMEDCT_US_2016_03_01:154404004|ICD9CM:112.1|SNOMEDCT_US_2016_03_01:187009004|MESH:D002181,Candidal vulvovaginitis (disorder)|Candidiasis of vulva and vagina|Monilial vulvovaginitis|Candidal vulvovaginitis|Vulvovaginal Candidiasis|Candidal vulvovaginitis NOS (disorder)|Candidal: [vulvovaginitis NOS] or [cervix],,disease_ontology,,DOID:2272,,,,,,,,,,,,,,,,,,,vulvovaginal candidiasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100536,"[""Olfactory receptor 2L5""]",,"An olfactory receptor 2L5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG80] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2L5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG80] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100536,,,,https://pharos.nih.gov/idg/targets/Q8NG80,,,,,,,,,,,,,OR2L5,OR2L11,,Q8NG80,,,,,,,,Olfactory receptor 2L5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100659,"[""Olfactory receptor 6f1""]",,"An olfactory receptor 6F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100659,,,,https://pharos.nih.gov/idg/targets/Q8NGZ6,,,,,,,,,,,,,OR6F1,,,Q8NGZ6,,,,,,,,Olfactory receptor 6f1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002860,"[""oral mucosa""]",,The mucous coat (membrane) lining the oral cavity.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000886,,,,,,,,The mucous coat (membrane) lining the oral cavity.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002860,,,,,,,BrendaTissueOBO,tunica mucosa oris,BTO:0002860,,,,,,,,,,,,,,,,,,,oral mucosa,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200222,"[""GRM5 gene""]",,"A metabotropic glutamate receptor 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41594] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400059,,,,,,,,"A metabotropic glutamate receptor 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41594] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200222,,,,,,,,,,,,,,,,2915,GRM5,GPRC1E|MGLUR5,,,,,,,,,,GRM5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_452,"[""pleomorphic adenoma""]",,A gastrointestinal benign neoplasm that is a located_in the salivary glands.,false,,,http://purl.obolibrary.org/obo/DOID_0050624,,,,,,,,A gastrointestinal benign neoplasm that is a located_in the salivary glands.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:452,,,,NCI:C35691|OMIM:181030|NCI:C8602|SNOMEDCT_US_2016_03_01:8360001|UMLS_CUI:C0026277|MESH:D008949,Pleomorphic adenoma|mixed tumor of the Salivary gland|Pleomorphic adenoma (morphologic abnormality),,disease_ontology,,DOID:452,,,,,,,,,,,,,,,,,,,pleomorphic adenoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_450,"[""myotonic disease""]",,A muscular dystrophy that is characterized by progressive muscle wasting and weakness.,false,,,http://purl.obolibrary.org/obo/DOID_9884,,,,,,,,A muscular dystrophy that is characterized by progressive muscle wasting and weakness.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:450,,,,MESH:D020967|NCI:C84913|SNOMEDCT_US_2016_03_01:155096007|UMLS_CUI:C0553604|ICD9CM:359.2|SNOMEDCT_US_2016_03_01:193240003|ICD10CM:G71.1|SNOMEDCT_US_2016_03_01:267713009|SNOMEDCT_US_2016_03_01:193237003,,,disease_ontology,,DOID:450,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,myotonic disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000290,"[""coronary artery""]",,Either of two arteries that arise one from the left and one from the right side of the aorta immediately above the semilunar valves and supply the tissues of the heart itself.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000573,,,,,,,,Either of two arteries that arise one from the left and one from the right side of the aorta immediately above the semilunar valves and supply the tissues of the heart itself.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000290,,,,,,,BrendaTissueOBO,,BTO:0000290,,,,,,,,,,,,,,,,,,,coronary artery,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200558,"[""ULK4 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400228,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200558,,,,,,,,,,,,,,,,54986,ULK4,,,,,,,,,,,ULK4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000137,"[""H3 relaxin (B chain)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000137,,,,,,,,,,,,,,,,,,,,,,,,,,,,H3 relaxin (B chain),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300138,"[""CDKL family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300111,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300138,,,,,,,,,,,,,,,,,,,,,,,,,,,,CDKL family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000263,"[""MARK3 kinase domain""]",,MAP/microtubule affinity-regulating kinase 3; CTAK1; KP78; MARK3; PAR1A,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,MAP/microtubule affinity-regulating kinase 3; CTAK1; KP78; MARK3; PAR1A,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000263,,,,,,,,,,,,,,,,,,,200248,,,,,,,,,MARK3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300389,"[""CACNA1I subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300333,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300389,,,,,,,,,,,,,,,,,,,,,,,,,,,,CACNA1I subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100655,"[""Olfactory receptor 6c2""]",,"An olfactory receptor 6C2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZP2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6C2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZP2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100655,,,,https://pharos.nih.gov/idg/targets/Q9NZP2,,,,,,,,,,,,,OR6C2,,,Q9NZP2,,,,,,,,Olfactory receptor 6c2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004779,"[""soft tissue sarcoma cell""]",,"A malignant tumor that begins in the muscle, fat, fibrous tissue, blood vessels, or other ""soft"" supporting tissues of the body. Soft tissue sarcomas do not originate in bone or cartilage.",false,,,http://purl.obolibrary.org/obo/BTO_0001801|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A malignant tumor that begins in the muscle, fat, fibrous tissue, blood vessels, or other ""soft"" supporting tissues of the body. Soft tissue sarcomas do not originate in bone or cartilage.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004779,mgr,2010-10-04T08:59:10Z,,,,,BrendaTissueOBO,,BTO:0004779,,,,,,,,,,,,,,,,,,,soft tissue sarcoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200439,"[""PRKY gene""]",,"This gene is similar to the protein kinase, X-linked gene in the pseudoautosomal region of the X chromosome. The gene is classified as a transcribed pseudogene because it has lost a coding exon that results in all transcripts being candidates for nonsense-mediated decay (NMD) and unlikely to express a protein. Abnormal recombination between this gene and a related gene on chromosome X is a frequent cause of XX males and XY females. [provided by RefSeq, Jul 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400169,,,,,,,,"This gene is similar to the protein kinase, X-linked gene in the pseudoautosomal region of the X chromosome. The gene is classified as a transcribed pseudogene because it has lost a coding exon that results in all transcripts being candidates for nonsense-mediated decay (NMD) and unlikely to express a protein. Abnormal recombination between this gene and a related gene on chromosome X is a frequent cause of XX males and XY females. [provided by RefSeq, Jul 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200439,,,,,,,,,,,,,,,,5616,PRKY,,,,,,,,,,,PRKY gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80132,"[""Apelin-36""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C15856,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80132,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80132,,,,,Apelin-36,,CHEBI:80132,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117498,"[""Nuclear receptor subfamily 1 group i member 3""]",,"A nuclear receptor subfamily 1 group I member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14994] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117466,,,,,,,,"A nuclear receptor subfamily 1 group I member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14994] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117498,,,,https://pharos.nih.gov/idg/targets/Q14994,,,,,,,,,,,,,NR1I3,,,Q14994,,,,,,,,Nuclear receptor subfamily 1 group i member 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000069,"[""WISH cell""]",,Human amnion cell line with HeLa markers.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000110,,,,,,,,Human amnion cell line with HeLa markers.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000069,,,,,,,BrendaTissueOBO,,BTO:0000069,,,,,,,,,,,,,,,,,,,WISH cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391035,"[""FRAP subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300129,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391035,,,,,,,,,,,,,,,,,,,,,,,,,,,,FRAP subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200039,"[""CACNA1B gene""]",,"The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400382,,,,,,,,"The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200039,,,,,,,,,,,,,,,,774,CACNA1B,CACH5|CACNL1A5,,,,,,,,,,CACNA1B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000124,"[""EGFR(L747-E749del, A750P) kinase domain""]",,"Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000124,,,,,,,,,,,,,,,,,,,200126,,,,,,,,,"EGFR(L747-E749del, A750P) kinase domain",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300529,"[""GLRB sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300409,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300529,,,,,,,,,,,,,,,,,,,,,,,,,,,,GLRB sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4280,"[""nodular basal cell carcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2513,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4280,,,DOID:4296,SNOMEDCT_US_2016_03_01:403910009|SNOMEDCT_US_2016_03_01:128636006|NCI:C62282|UMLS_CUI:C1304300,"skin nodulo-ulcerative basal cell carcinoma|Circumscribed solid basal cell carcinoma|skin solid (nodular) Basal cell carcinoma|Basal cell carcinoma, nodular (morphologic abnormality)",,disease_ontology,,DOID:4280,,,,,,,,,,,,,,,,,,,nodular basal cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200373,"[""OR2T33 gene""]",,"An olfactory receptor 2T33 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG76] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2T33 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG76] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200373,,,,,,,,,,,,,,,,391195,OR2T33,,,,,,,,,,,OR2T33 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100070,"[""Cannabinoid receptor 1""]",,"A cannabinoid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21554] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300035,,,,,,,,"A cannabinoid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21554] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100070,,,,https://pharos.nih.gov/idg/targets/P21554,,,,,,,,,,,,,CNR1,CNR,,P21554,,,,,,,,Cannabinoid receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400528,"[""GLRA4 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400409,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400528,,,,,,,,,,,,,,,,,,,,,,,,,,,,GLRA4 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_15713,"[""UTP""]","
[[[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid
|PGAVKCOVUIYSFO-XVFCMESISA-N|Uridine mono(tetrahydrogen triphosphate)|
O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
|
({[({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid
|Uteplex|C9H15N2O15P3|H4utp|
InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
|5'-UTP|uridine 5'-triphosphoric acid|Uridine triphosphate|Uridine 5'-triphosphate|
[[[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid
","
A pyrimidine ribonucleoside 5'-triphosphate having uracil as the nucleobase.
",false,,,http://purl.obolibrary.org/obo/CHEBI_36976,,,,,,,KEGG COMPOUND:C00075|CiteXplore:6734601|ChemIDplus:63-39-8|CiteXplore:10927039|MetaCyc:UTP|Beilstein:71520|Gmelin:307896|DrugBank:DB04005|KEGG COMPOUND:63-39-8|CiteXplore:14719996|HMDB:HMDB00285|CiteXplore:15837087|Wikipedia:Uridine triphosphate|PDBeChem:UTP,"
A pyrimidine ribonucleoside 5'-triphosphate having uracil as the nucleobase.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:9850|CHEBI:27233|CHEBI:13510,,UTP|uridine 5'-(tetrahydrogen triphosphate),,chebi_ontology,"
[[[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid
|PGAVKCOVUIYSFO-XVFCMESISA-N|Uridine mono(tetrahydrogen triphosphate)|
O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
|
({[({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid
|Uteplex|C9H15N2O15P3|H4utp|
InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
|5'-UTP|uridine 5'-triphosphoric acid|Uridine triphosphate|Uridine 5'-triphosphate|
[[[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid
",,,CHEBI:15713,,,,,,,,,,,,,,,,,,,,,,,CHEBI:15713,,,,,UTP,,CHEBI:15713,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000988,"[""pancreas""]",,A large lobulated gland of vertebrates that secretes digestive enzymes and the hormones insulin and glucagon.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000345|http://purl.obolibrary.org/obo/BTO_0001491|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,,A large lobulated gland of vertebrates that secretes digestive enzymes and the hormones insulin and glucagon.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000988,,,,,,,BrendaTissueOBO,,BTO:0000988,,,,,,,,,,,,,,,,,,,pancreas,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002126,"[""U-373MG cell""]",,Human caucasian glioblastoma-astrocytoma cell line; established from a 61-years-old caucasian male.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001530,,,,,,,,Human caucasian glioblastoma-astrocytoma cell line; established from a 61-years-old caucasian male.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002126,,,,,,,BrendaTissueOBO,U-373 cell|U-373 MG cell|U373MG cell,BTO:0002126,,,,,,,,,,,,,,,,,,,U-373MG cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000801,"[""macrophage""]",,"Relatively long-lived phagocytic cell of mammalian tissues, derived from blood monocyte. Macrophages from different sites have distinctly different properties. Main types are peritoneal and alveolar macrophages, tissue macrophages (histiocytes), Kupffer cells of the liver, and osteoclasts. In response to foreign materials may become stimulated or activated. Macrophages play an important role in killing of some bacteria, protozoa, and tumour cells, release substances that stimulate other cells of the immune system, and are involved in antigen presentation. May further differentiate within chronic inflammatory lesions to epithelioid cells or may fuse to form foreign body giant cells or Langhans giant cells.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Relatively long-lived phagocytic cell of mammalian tissues, derived from blood monocyte. Macrophages from different sites have distinctly different properties. Main types are peritoneal and alveolar macrophages, tissue macrophages (histiocytes), Kupffer cells of the liver, and osteoclasts. In response to foreign materials may become stimulated or activated. Macrophages play an important role in killing of some bacteria, protozoa, and tumour cells, release substances that stimulate other cells of the immune system, and are involved in antigen presentation. May further differentiate within chronic inflammatory lesions to epithelioid cells or may fuse to form foreign body giant cells or Langhans giant cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000801,,,,,,,BrendaTissueOBO,monocyte-derived macrophage|macrophagocyte,BTO:0000801,,,,,,,,,,,,,,,,,,,macrophage,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000089,"[""blood""]",,"1: The fluid that circulates in the heart, arteries, capillaries, and veins of a vertebrate animal carrying nourishment and oxygen to and bringing away waste products from all parts of the body. 2: A comparable fluid of an invertebrate.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"1: The fluid that circulates in the heart, arteries, capillaries, and veins of a vertebrate animal carrying nourishment and oxygen to and bringing away waste products from all parts of the body. 2: A comparable fluid of an invertebrate.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000089,,,,,,,BrendaTissueOBO,whole blood,BTO:0000089,,,,,,,,,,,,,,,,,,,blood,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200213,"[""GPR85 gene""]",,"A G-protein coupled receptor 85 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P60893] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 85 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P60893] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200213,,,,,,,,,,,,,,,,54329,GPR85,SREB2,,,,,,,,,,GPR85 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200378,"[""PIK3C2A gene""]",,"The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03491010,,,,,,,,"The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200378,,,,,,,,,,,,,,,,5286,PIK3C2A,,,,,,,,,,,PIK3C2A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300231,"[""TAF1 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300108,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300231,,,,,,,,,,,,,,,,,,,,,,,,,,,,TAF1 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100820,"[""Vomeronasal type-1 receptor 1""]",,"A vomeronasal type-1 receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZP7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300016,,,,,,,,"A vomeronasal type-1 receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZP7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100820,,,,https://pharos.nih.gov/idg/targets/Q9GZP7,,,,,,,,,,,,,VN1R1,V1RL1|VNR19I1,,Q9GZP7,,,,,,,,Vomeronasal type-1 receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400261,"[""CDK5 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400136,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400261,,,,,,,,,,,,,,,,,,,,,,,,,,,,CDK5 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000391,"[""THR748 in EPHB6""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000391,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR748 in EPHB6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200301,"[""SCN10A gene""]",,"The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_01400475,,,,,,,,"The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200301,,,,,,,,,,,,,,,,6336,SCN10A,,,,,,,,,,,SCN10A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10113,"[""trypanosomiasis""]",,A parasitic protozoa infectious disease that involves infection caused by parasitic protozoan of the genus Trypanosoma in animals and humans.,false,,,http://purl.obolibrary.org/obo/DOID_2789,,,,,,,,A parasitic protozoa infectious disease that involves infection caused by parasitic protozoan of the genus Trypanosoma in animals and humans.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10113,,,,SNOMEDCT_US_2016_03_01:186819000|UMLS_CUI:C0041227|SNOMEDCT_US_2016_03_01:266205000|ICD10CM:B57.2|ICD9CM:086.9|ICD9CM:086|SNOMEDCT_US_2016_03_01:154375001|MESH:D014352|SNOMEDCT_US_2016_03_01:78940002,,,disease_ontology,,DOID:10113,,,,,,,,,,,,,,,,,,,trypanosomiasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10112,"[""sleeping sickness""]",,"A trypanosomiasis that results from infection by Trypanosoma brucei and gambiense, which is transmitted by the bite of an infected tsetse fly (Glossina spp). The symptoms include fever, headache, joint pain, itching, confusion, sensory disturbances, poor coordination and sleep disturbances.",false,,,http://purl.obolibrary.org/obo/DOID_10113,,,,,,,,"A trypanosomiasis that results from infection by Trypanosoma brucei and gambiense, which is transmitted by the bite of an infected tsetse fly (Glossina spp). The symptoms include fever, headache, joint pain, itching, confusion, sensory disturbances, poor coordination and sleep disturbances.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10112,,,,ICD10CM:B56.9|UMLS_CUI:C0041228|ICD10CM:B56|MESH:D014353|SNOMEDCT_US_2016_03_01:27031003|NCI:C84541|SNOMEDCT_US_2016_03_01:187512007|SNOMEDCT_US_2016_03_01:186818008|KEGG:05143|ICD9CM:086.5|SNOMEDCT_US_2016_03_01:78940002,African sleeping sickness|African trypanosomiasis,,disease_ontology,,DOID:10112,http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,sleeping sickness,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100249,"[""Serine/threonine-protein kinase h2""]",,"A serine/threonine-protein kinase H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96QS6] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300177,,,,,,,,"A serine/threonine-protein kinase H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96QS6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100249,,,,https://pharos.nih.gov/idg/targets/Q96QS6,,,,,,,,,,,,,PSKH2,,,Q96QS6,,,,,,,,Serine/threonine-protein kinase h2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100037,"[""Aurora kinase c""]",,"An aurora kinase C that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UQB9] |aurora kinase c (AURKC)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300130,,,,,,,,"An aurora kinase C that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UQB9] |aurora kinase c (AURKC)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100037,,,,https://pharos.nih.gov/idg/targets/Q9UQB9,,,,,,,,,,,,,AURKC,AIE2|AIK3|AIRK3|ARK3|STK13,,Q9UQB9,,,,,,,,Aurora kinase c,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200177,"[""GPR12 gene""]",,"A G-protein coupled receptor 12 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47775] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 12 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47775] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200177,,,,,,,,,,,,,,,,2835,GPR12,,,,,,,,,,,GPR12 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200110,"[""GABRA4 gene""]",,"Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400509,,,,,,,,"Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200110,,,,,,,,,,,,,,,,2557,GABRA4,,,,,,,,,,,GABRA4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100050,"[""Voltage-dependent l-type calcium channel subunit beta-3""]",,"A voltage-dependent L-type calcium channel subunit beta-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54284] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300334,,,,,,,,"A voltage-dependent L-type calcium channel subunit beta-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54284] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100050,,,,https://pharos.nih.gov/idg/targets/P54284,,,,,,,,,,,,,CACNB3,CACNLB3,,P54284,,,,,,,,Voltage-dependent l-type calcium channel subunit beta-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_16893,"[""sphinganine 1-phosphate""]","
InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/t17-,18+/m0/s1
|
{[(2S,3R)-2-amino-3-hydroxyoctadecyl]oxy}phosphonic acid
|C18H40NO5P|YHEDRJPUIRMZMP-ZWKOTPCHSA-N|dihydrosphingosine-1-phosphate|
(2S,3R)-2-amino-3-hydroxyoctadecyl dihydrogen phosphate
|2-Amino-3-hydroxyoctadecyl dihydrogen phosphate|Dihydrosphingosine 1-phosphate|CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)COP(O)(O)=O","
A sphingoid 1-phosphate that is the monophosphorylated derivative of sphinganine.
",false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,Reaxys:6780476|CiteXplore:20671299|Beilstein:6780476|KEGG COMPOUND:C01120|HMDB:HMDB01383|ChemIDplus:19794-97-9|LIPID MAPS:LMSP01050002|KNApSAcK:C00007541|MetaCyc:CPD-649|KEGG COMPOUND:19794-97-9,"
A sphingoid 1-phosphate that is the monophosphorylated derivative of sphinganine.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:23767|CHEBI:9222|CHEBI:15100,,sphinganine 1-(dihydrogen phosphate)|Sphinganine 1-phosphate,,chebi_ontology,"
InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/t17-,18+/m0/s1
|
{[(2S,3R)-2-amino-3-hydroxyoctadecyl]oxy}phosphonic acid
|C18H40NO5P|YHEDRJPUIRMZMP-ZWKOTPCHSA-N|dihydrosphingosine-1-phosphate|
(2S,3R)-2-amino-3-hydroxyoctadecyl dihydrogen phosphate
|2-Amino-3-hydroxyoctadecyl dihydrogen phosphate|Dihydrosphingosine 1-phosphate|CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)COP(O)(O)=O",,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:16893,,,,,Dihydrosphingosine-1-phosphate|sphinganine 1-phosphate,,CHEBI:16893,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000313,"[""NEK3 kinase domain""]",,NIMA (never in mitosis gene a)-related kinase 3; HSPK36; MGC29949; NEK3,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,NIMA (never in mitosis gene a)-related kinase 3; HSPK36; MGC29949; NEK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000313,,,,,,,,,,,,,,,,,,,200289,,,,,,,,,NEK3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1412,"[""bacteriuria""]",,A urinary system disease which consists of the presence of bacteria in urine.,false,,,http://purl.obolibrary.org/obo/DOID_18,,,,,,,,A urinary system disease which consists of the presence of bacteria in urine.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1412,,,,SNOMEDCT_US_2016_03_01:61373006|MESH:D001437|UMLS_CUI:C0004659|CSP:3045-9976|MedDRA:10004056|HP:0012461,,,disease_ontology,,DOID:1412,,,,,,,,,,,,,,,,,,,bacteriuria,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200620,"[""PRPS1L1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200620,,,,,,,,,,,,,,,,,,,,,,,,,,,,PRPS1L1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200012,"[""HTR7 gene""]",,"A 5-hydroxytryptamine receptor 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P34969] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402006,,,,,,,,"A 5-hydroxytryptamine receptor 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P34969] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200012,,,,,,,,,,,,,,,,3363,HTR7,,,,,,,,,,,HTR7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200056,"[""CDC7 gene""]",,"This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400137,,,,,,,,"This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200056,,,,,,,,,,,,,,,,8317,CDC7,CDC7L1,,,,,,,,,,CDC7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002107,"[""submucosa""]",,"The layer of areolar tissue situated beneath the mucous membrane. The layer of loose connective tissue between the lamina muscularis mucosae and the tunica muscularis in most parts of the digestive, respiratory, urinary, and genital tracts.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000886,,,,,,,,"The layer of areolar tissue situated beneath the mucous membrane. The layer of loose connective tissue between the lamina muscularis mucosae and the tunica muscularis in most parts of the digestive, respiratory, urinary, and genital tracts.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002107,,,,,,,BrendaTissueOBO,tela submucosa|submucous layer,BTO:0002107,,,,,,,,,,,,,,,,,,,submucosa,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100691,"[""Olfactory receptor 8D1""]",,"An olfactory receptor 8D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZ84] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 8D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZ84] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100691,,,,https://pharos.nih.gov/idg/targets/Q8WZ84,,,,,,,,,,,,,OR8D1,OR8D3,,Q8WZ84,,,,,,,,Olfactory receptor 8D1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300123,"[""Alpha family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300108,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300123,,,,,,,,,,,,,,,,,,,,,,,,,,,,Alpha family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_24432,"[""biological role""]",,A role played by the molecular entity or part thereof within a biological context.,false,,,http://purl.obolibrary.org/obo/BFO_0000023,,,,,,,,A role played by the molecular entity or part thereof within a biological context.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:24432,,,,,,,chebi_ontology,biological function,CHEBI:24432,http://purl.obolibrary.org/obo/chebi#3_STAR,,,,,,,,,,,,,,,,,,biological role,,,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000220,"[""MET91 in ULK3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000220,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET91 in ULK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400459,"[""NR1/GRIN1 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400459,,,,,,,,,,,,,,,,,,,,,,,,,,,,NR1/GRIN1 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10816,"[""duodenum adenocarcinoma""]",,A duodenum cancer that derives_from epithelial cells of glandular origin.,false,,,http://purl.obolibrary.org/obo/DOID_4906|http://purl.obolibrary.org/obo/DOID_10021,,,,,,,,A duodenum cancer that derives_from epithelial cells of glandular origin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10816,,,,SNOMEDCT_US_2016_03_01:408644002|UMLS_CUI:C0278804|NCI:C7889,Duodenal adenocarcinoma|adenocarcinoma of duodenum (disorder),,disease_ontology,adenocarcinoma of duodenum,DOID:10816,,,,,,,,,,,,,,,,,,,duodenum adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10811,"[""nasal cavity cancer""]",,A respiratory system cancer that is located_in the nasal cavity.,false,,,http://purl.obolibrary.org/obo/DOID_2163|http://purl.obolibrary.org/obo/DOID_0050615,,,,,,,,A respiratory system cancer that is located_in the nasal cavity.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10811,,,,SNOMEDCT_US_2016_03_01:187832001|ICD10CM:C30.0|SNOMEDCT_US_2016_03_01:93917007|ICD9CM:160.0|UMLS_CUI:C0728864|SNOMEDCT_US_2016_03_01:363422006|NCI:C4918,malignant neoplasm of nasal cavities|malignant tumor of the nasal cavity,,disease_ontology,,DOID:10811,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,nasal cavity cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300311,"[""RIO2 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300217,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300311,,,,,,,,,,,,,,,,,,,,,,,,,,,,RIO2 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000008,"[""C5a des-Arg""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000008,,,,,,,,,,,,,,,,,,,,,,,,,,,,C5a des-Arg,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000108,"[""MET121 in PKAC-alpha""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000108,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET121 in PKAC-alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100140,"[""Glutamate receptor ionotropic, kainate 2""]",,"A glutamate receptor ionotropic, kainate 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13002] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300417,,,,,,,,"A glutamate receptor ionotropic, kainate 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13002] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100140,,,,https://pharos.nih.gov/idg/targets/Q13002,,,,,,,,,,,,,GRIK2,GLUR6,,Q13002,,,,,,,,"Glutamate receptor ionotropic, kainate 2",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200066,"[""CLCA2 gene""]",,"The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400339,,,,,,,,"The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200066,,,,,,,,,,,,,,,,9635,CLCA2,CACC3,,,,,,,,,,CLCA2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000191,"[""medullary carcinoma cell""]",,A cell of a carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000176,,,,,,,,A cell of a carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000191,,,,,,,BrendaTissueOBO,carcinoma molle cell|carcinoma spongiosum cell|cerebriform cancer cell|cerebriform carcinoma cell|encephaloid cancer cell|soft cancer cell,BTO:0000191,,,,,,,,,,,,,,,,,,,medullary carcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000942,"[""NG-108-15 cell""]",,Neuroblastoma glioma hybrid cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000932|http://purl.obolibrary.org/obo/BTO_0000711,,,,,,,,Neuroblastoma glioma hybrid cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000942,,,,,,,BrendaTissueOBO,NG 108-15 cell|NG108-15 cell,BTO:0000942,,,,,,,,,,,,,,,,,,,NG-108-15 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14219,"[""renal tubular acidosis""]",,"A renal tubular transport disease characterized by excess levels of acid in the blood, due to a failure of the kidneys to appropriately acidify the urine.",false,,,http://purl.obolibrary.org/obo/DOID_447,,,,,,,,"A renal tubular transport disease characterized by excess levels of acid in the blood, due to a failure of the kidneys to appropriately acidify the urine.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14219,,,,NCI:C28129|ICD10CM:N25.89|OMIM:267200|UMLS_CUI:C0001126|MESH:D000141|OMIM:602722|SNOMEDCT_US_2016_03_01:1776003|OMIM:179830,,,disease_ontology,,DOID:14219,,,,,,,,,,,,,,,,,Xref MGI.,,renal tubular acidosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12161,"[""peripheral retinal degeneration""]",,,false,,,http://purl.obolibrary.org/obo/DOID_8466,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12161,,,,SNOMEDCT_US_2016_03_01:193393004|SNOMEDCT_US_2016_03_01:95704002|ICD9CM:362.6|UMLS_CUI:C1320640|ICD9CM:362.60|ICD10CM:H35.40|SNOMEDCT_US_2016_03_01:61536007|SNOMEDCT_US_2016_03_01:193398008|SNOMEDCT_US_2016_03_01:405721006|NCI:C34919|ICD10CM:H35.4|SNOMEDCT_US_2016_03_01:193394005,peripheral degeneration of retina,,disease_ontology,,DOID:12161,,,,,,,,,,,,,,,,,,,peripheral retinal degeneration,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000029,"[""Wnt-3a""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000029,,,,,,,,,,,,,,,,,,,,,,,,,,,,Wnt-3a,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200082,"[""DRD2 gene""]",,"A D(2) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P14416] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400037,,,,,,,,"A D(2) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P14416] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200082,,,,,,,,,,,,,,,,1813,DRD2,,,,,,,,,,,DRD2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_63000006,"[""Pkinase""]",,"A Pfam protein family that is a structurally conserved protein domain containing the catalytic function of protein kinases. Protein kinases are a group of enzymes that move a phosphate group onto proteins, in a process called phosphorylation. This functions as an on/off switch for many cellular processes, including metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. They also function in embryonic development, physiological responses, and in the nervous and immune system. Abnormal phosphorylation causes many human diseases, including cancer, and drugs that affect phosphorylation can treat those diseases.",false,,,http://www.drugtargetontology.org/dto/DTO_63000000,,,,,,,,"A Pfam protein family that is a structurally conserved protein domain containing the catalytic function of protein kinases. Protein kinases are a group of enzymes that move a phosphate group onto proteins, in a process called phosphorylation. This functions as an on/off switch for many cellular processes, including metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. They also function in embryonic development, physiological responses, and in the nervous and immune system. Abnormal phosphorylation causes many human diseases, including cancer, and drugs that affect phosphorylation can treat those diseases.",http://pfam.xfam.org/family/PF00069,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_63000006,,,,,,,,,,,,,,,,,,,,,,,,,,,,Pkinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005084,"[""vocal fold""]",,Either of two pairs of folds of mucous membrane projecting into the larynx.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Either of two pairs of folds of mucous membrane projecting into the larynx.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005084,XPMUser,2011-03-07T08:43:12Z,,,,,BrendaTissueOBO,Stimmlippe|plica vocalis|vocal cord|vocal band|vocal chord|Stimmband,BTO:0005084,,,,,,,,,,,,,,,,,,,vocal fold,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200223,"[""CKM gene""]",,"The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03491027,,,,,,,,"The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200223,,,,,,,,,,,,,,,,1158,CKM,CKMM,,,,,,,,,,CKM gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_350,"[""mastocytosis""]",,OMIM mapping confirmed by DO. [LS].,false,,,http://purl.obolibrary.org/obo/DOID_9500,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:350,,,,SNOMEDCT_US_2016_03_01:397007003|SNOMEDCT_US_2016_03_01:78745000|ICD10CM:Q82.2|UMLS_CUI:C0024899|SNOMEDCT_US_2016_03_01:125541005|OMIM:154800|MESH:D008415|NCI:C84269,mast cell hyperplasia,,disease_ontology,,DOID:350,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,mastocytosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5113,"[""nutritional deficiency disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_374,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5113,,,,UMLS_CUI:C0011156|MESH:D003677,,,disease_ontology,,DOID:5113,,,,,,,,,,,,,,,,,,,nutritional deficiency disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000136,"[""MET166 in NDR1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000136,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET166 in NDR1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100677,"[""Olfactory receptor 7a17""]",,"An olfactory receptor 7A17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14581] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 7A17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14581] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100677,,,,https://pharos.nih.gov/idg/targets/O14581,,,,,,,,,,,,,OR7A17,,,O14581,,,,,,,,Olfactory receptor 7a17,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200406,"[""OR51T1 gene""]",,"An olfactory receptor 51T1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 51T1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200406,,,,,,,,,,,,,,,,401665,OR51T1,,,,,,,,,,,OR51T1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000936,"[""neurofibrillary tangle""]",,Intracellular knot or clump of neurofibrils seen in the cerebral cortex in Alzheimer's disease.,false,,,http://purl.obolibrary.org/obo/BTO_0000590|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Intracellular knot or clump of neurofibrils seen in the cerebral cortex in Alzheimer's disease.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000936,,,,,,,BrendaTissueOBO,neurofilament tangle,BTO:0000936,,,,,,,,,,,,,,,,,,,neurofibrillary tangle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300195,"[""MUSK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300195,,,,,,,,,,,,,,,,,,,,,,,,,,,,MUSK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00000010,"[""amine GPCR ligand""]",,A GPCR ligand that is classified as amine in CHEBI.,false,,,http://www.drugtargetontology.org/dto/DTO_00000001|http://purl.obolibrary.org/obo/CHEBI_32952,,,,,,,,A GPCR ligand that is classified as amine in CHEBI.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00000010,,,,,,,,,,,,,,,,,,,,,,,,,,,Asiyah Yu Lin,amine GPCR ligand,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100297,"[""Sodium channel protein type 5 subunit alpha""]",,"A sodium channel protein type 5 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14524] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300471,,,,,,,,"A sodium channel protein type 5 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14524] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100297,,,,https://pharos.nih.gov/idg/targets/Q14524,,,,,,,,,,,,,SCN5A,,,Q14524,,,,,,,,Sodium channel protein type 5 subunit alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200145,"[""PTK2B gene""]",,"This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400155,,,,,,,,"This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200145,,,,,,,,,,,,,,,,2185,PTK2B,FAK2|PYK2|RAFTK,,,,,,,,,,PTK2B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200159,"[""GPR158 gene""]",,"A G-protein coupled receptor 158 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5T848] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400004,,,,,,,,"A G-protein coupled receptor 158 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5T848] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200159,,,,,,,,,,,,,,,,57512,GPR158,KIAA1136,,,,,,,,,,GPR158 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000545,"[""gut""]",,"1: The alimentary canal or a portion thereof, especially the intestine or stomach. 2: The embryonic digestive tube, consisting of the foregut, the midgut, and the hindgut.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"1: The alimentary canal or a portion thereof, especially the intestine or stomach. 2: The embryonic digestive tube, consisting of the foregut, the midgut, and the hindgut.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000545,,,,,,,BrendaTissueOBO,,BTO:0000545,,,,,,,,,,,,,,,,,,,gut,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9080,"[""macroglobulinemia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2345,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9080,,,,UMLS_CUI:C0024419|SNOMEDCT_US_2016_03_01:190821002|UMLS_CUI:C2936755|SNOMEDCT_US_2016_03_01:154750002|ICD10CM:C88.0|SNOMEDCT_US_2016_03_01:190817009|SNOMEDCT_US_2016_03_01:35562000|SNOMEDCT_US_2016_03_01:190818004|ICD9CM:273.3|MESH:D008258|SNOMEDCT_US_2016_03_01:267503004|NCI:C80307|SNOMEDCT_US_2016_03_01:190014001|SNOMEDCT_US_2016_03_01:109981009|NCI:C115212,primary macroglobulinemia,,disease_ontology,,DOID:9080,,,,,,,,,,,,,,,,,,,macroglobulinemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12196,"[""superficial keratitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4677,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12196,,,,ICD9CM:370.20|UMLS_CUI:C0155074|ICD10CM:H16.10|SNOMEDCT_US_2016_03_01:27019000|SNOMEDCT_US_2016_03_01:193766004,,,disease_ontology,,DOID:12196,,,,,,,,,,,,,,,,,,,superficial keratitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12197,"[""punctate epithelial keratoconjunctivitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_12196|http://purl.obolibrary.org/obo/DOID_9368,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12197,,,,ICD9CM:370.21|ICD10CM:H16.14|SNOMEDCT_US_2016_03_01:267634006|SNOMEDCT_US_2016_03_01:416069001|UMLS_CUI:C0259799|SNOMEDCT_US_2016_03_01:42513006|SNOMEDCT_US_2016_03_01:193767008,Thygeson superficial punctate keratitis|Thygeson's superficial punctate keratitis|Punctate keratitis,,disease_ontology,,DOID:12197,,,,,,,,,,,,,,,,,,,punctate epithelial keratoconjunctivitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14766,"[""renal agenesis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_557,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14766,,,,OMIM:191830,hereditary renal aplasia|renal adysplasia|renal aplasia|hereditary urogenital adysplasia,,disease_ontology,,DOID:14766,,,,,,,,,,,,,,,,,,,renal agenesis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300141,"[""PDGFR family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300141,,,,,,,,,,,,,,,,,,,,,,,,,,,,PDGFR family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200671,"[""OR6V1 gene""]",,"An olfactory receptor 6V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N148] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N148] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200671,,,,,,,,,,,,,,,,346517,OR6V1,,,,,,,,,,,OR6V1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200324,"[""MAPK12 gene""]",,"Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400294,,,,,,,,"Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200324,,,,,,,,,,,,,,,,6300,MAPK12,ERK6|SAPK3,,,,,,,,,,MAPK12 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003209,"[""anaplastic thyroid cancer cell line""]",,Cells to a more primitive or undifferentiated form of thyroid cancer.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001610,,,,,,,,Cells to a more primitive or undifferentiated form of thyroid cancer.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003209,,,,,,,BrendaTissueOBO,,BTO:0003209,,,,,,,,,,,,,,,,,,,anaplastic thyroid cancer cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004438,"[""HSCC cell""]",,Human squamous cell carcinoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002024,,,,,,,,Human squamous cell carcinoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004438,Marion,2010-02-02T03:08:47Z,,,,,BrendaTissueOBO,human SCC cell|hSCC cell,BTO:0004438,,,,,,,,,,,,,,,,,,,HSCC cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200298,"[""MAK gene""]",,"The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400162,,,,,,,,"The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200298,,,,,,,,,,,,,,,,4117,MAK,,,,,,,,,,,MAK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005669,"[""NCI-H295A cell""]",,"NCI-H295A cells are an adherent subline of human adrenocortical carcinoma NCI-H295 cells that express all adrenal steroidogenic enzymes in a physiologically appropriate, hormonal responsive fashion.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"NCI-H295A cells are an adherent subline of human adrenocortical carcinoma NCI-H295 cells that express all adrenal steroidogenic enzymes in a physiologically appropriate, hormonal responsive fashion.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005669,Marion,2014-09-05T08:38:16Z,,,,,BrendaTissueOBO,H295A cell,BTO:0005669,,,,,,,,,,,,,,,,,,,NCI-H295A cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200781,"[""TAS2R20 gene""]",,"A taste receptor type 2 member 20 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59543] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400014,,,,,,,,"A taste receptor type 2 member 20 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59543] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200781,,,,,,,,,,,,,,,,259295,TAS2R20,TAS2R49,,,,,,,,,,TAS2R20 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100567,"[""Serine/threonine-protein kinase wnk1""]",,"A serine/threonine-protein kinase WNK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H4A3] |serine/threonine-protein kinase wnk1 (WNK1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300244,,,,,,,,"A serine/threonine-protein kinase WNK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H4A3] |serine/threonine-protein kinase wnk1 (WNK1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100567,,,,https://pharos.nih.gov/idg/targets/Q9H4A3,,,,,,,,,,,,,WNK1,HSN2|KDP|KIAA0344|PRKWNK1,,Q9H4A3,,,,,,,,Serine/threonine-protein kinase wnk1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400166,"[""IRAK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400107,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400166,,,,,,,,,,,,,,,,,,,,,,,,,,,,IRAK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200214,"[""CAMK1 gene""]",,"Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade.  Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400171,,,,,,,,"Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade.  Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200214,,,,,,,,,,,,,,,,8536,CAMK1,,,,,,,,,,,CAMK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002610,"[""pseudopodium""]",,A temporary cytoplasmic extrusion by means of which an ameba or other ameboid organism or cell moves about or engulfs food.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001262,,,,,,,,A temporary cytoplasmic extrusion by means of which an ameba or other ameboid organism or cell moves about or engulfs food.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002610,,,,,,,BrendaTissueOBO,,BTO:0002610,,,,,,,,,,,,,,,,,,,pseudopodium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001996,"[""endometrial cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001996,,,,,,,BrendaTissueOBO,,BTO:0001996,,,,,,,,,,,,,,,,,,,endometrial cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100559,"[""Vascular endothelial growth factor receptor 1""]",,A vascular endothelial growth factor receptor 1 that is encoded in the genome of human. [PRO:CNA] |vascular endothelial growth factor receptor 1 (VGFR1)  with  no mutation  in a nonphosphorylated state,false,,,http://www.drugtargetontology.org/dto/DTO_03300242,,,,,,,,A vascular endothelial growth factor receptor 1 that is encoded in the genome of human. [PRO:CNA] |vascular endothelial growth factor receptor 1 (VGFR1)  with  no mutation  in a nonphosphorylated state,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100559,,,,https://pharos.nih.gov/idg/targets/P17948,,,,,,,,,,,,,FLT1,FLT|FRT|VEGFR1,,P17948,,,,,,,,Vascular endothelial growth factor receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000444,"[""VAL""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_33700,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62000444,,,,,,,,,,,,,,,,,,,,,,,,,,,,VAL,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050138,"[""podoconiosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4976,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050138,,,,,,,disease_ontology,,DOID:0050138,,,,,,,,,,,,,,,,,,,podoconiosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050134,"[""cutaneous mycosis""]",,"A fungal infectious disease that results_in infection of the keratinized layers located_in skin, located_in hair or located_in nail, which extends deeper into the epidermis, has_material_basis_in Fungi and results_in_formation_of skin lesions.",false,,,http://purl.obolibrary.org/obo/DOID_1564,,,,,,,,"A fungal infectious disease that results_in infection of the keratinized layers located_in skin, located_in hair or located_in nail, which extends deeper into the epidermis, has_material_basis_in Fungi and results_in_formation_of skin lesions.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050134,,,,,,,disease_ontology,,DOID:0050134,,,,,,,,,,,,,,,,,,,cutaneous mycosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050133,"[""superficial mycosis""]",,"A fungal infectious disease that results_in infection of the outermost layer located_in skin or located_in hair shaft, has_material_basis_in Fungi. No living tissue is invaded and there is no cellular response from the host.",false,,,http://purl.obolibrary.org/obo/DOID_1564,,,,,,,,"A fungal infectious disease that results_in infection of the outermost layer located_in skin or located_in hair shaft, has_material_basis_in Fungi. No living tissue is invaded and there is no cellular response from the host.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050133,,,DOID:13370,UMLS_CUI:C0031898|SNOMEDCT_US_2016_03_01:154408001|SNOMEDCT_US_2016_03_01:276206000|SNOMEDCT_US_2016_03_01:187476003|SNOMEDCT_US_2016_03_01:187002008|SNOMEDCT_US_2016_03_01:47382004|ICD10CM:B36.9|UMLS_CUI:C2980104|SNOMEDCT_US_2016_03_01:402135006|SNOMEDCT_US_2016_03_01:266218008|MESH:D010854,piedra|Steroid-modified tinea infection,,disease_ontology,,DOID:0050133,,,,,,,,,,,,,,,,,Adding a UMLS CUI for piedra C2980104.,,superficial mycosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050136,"[""systemic mycosis""]",,"A fungal infectious disease that results_in infection of internal organs and tissues located_in human body, has_material_basis_in Fungi, which enter the body via the respiratory tract, through the gut, paranasal sinuses or skin and spread through the bloodstream to multiple organs.",false,,,http://purl.obolibrary.org/obo/DOID_1564,,,,,,,,"A fungal infectious disease that results_in infection of internal organs and tissues located_in human body, has_material_basis_in Fungi, which enter the body via the respiratory tract, through the gut, paranasal sinuses or skin and spread through the bloodstream to multiple organs.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050136,,,,,,,disease_ontology,,DOID:0050136,,,,,,,,,,,,,,,,,,,systemic mycosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002285,"[""granulosa cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002290,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002285,,,,,,,BrendaTissueOBO,primary granulosa cell line,BTO:0002285,,,,,,,,,,,,,,,,,,,granulosa cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400362,"[""Membrane protein mlc1 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400362,,,,,,,,,,,,,,,,,,,,,,,,,,,,Membrane protein mlc1 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8791,"[""breast carcinoma in situ""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3463|http://purl.obolibrary.org/obo/DOID_8719,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8791,,,,ICD9CM:233.0|NCI:C3641|SNOMEDCT_US_2016_03_01:154636004|ICD10CM:D05|SNOMEDCT_US_2016_03_01:189336000|UMLS_CUI:C0154084|ICD10CM:D05.9,Non-Infiltrating carcinoma of breast|carcinoma in situ of breast,,disease_ontology,,DOID:8791,,,,,,,,,,,,,,,,,,,breast carcinoma in situ,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100366,"[""Serine/threonine-protein kinase nlk""]",,"A serine/threonine-protein kinase NLK that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UBE8] |serine/threonine-protein kinase nlk (NLK)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300300,,,,,,,,"A serine/threonine-protein kinase NLK that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UBE8] |serine/threonine-protein kinase nlk (NLK)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100366,,,,https://pharos.nih.gov/idg/targets/Q9UBE8,,,,,,,,,,,,,NLK,LAK1,,Q9UBE8,,,,,,,,Serine/threonine-protein kinase nlk,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000968,"[""osteoclast""]",,"A large multinucleate cell found in growing bone that resorbs bony tissue, as in the formation of canals and cavities.",false,,,http://purl.obolibrary.org/obo/BTO_0000801|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002050,,,,,,,,"A large multinucleate cell found in growing bone that resorbs bony tissue, as in the formation of canals and cavities.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000968,,,,,,,BrendaTissueOBO,,BTO:0000968,,,,,,,,,,,,,,,,,,,osteoclast,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100283,"[""Mitogen-activated protein kinase kinase kinase 1""]",,"mitogen-activated protein kinase kinase kinase 1 (MAP3K1)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase kinase kinase 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13233] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300186,,,,,,,,"mitogen-activated protein kinase kinase kinase 1 (MAP3K1)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase kinase kinase 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13233] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100283,,,,https://pharos.nih.gov/idg/targets/Q13233,,,,,,,,,,,,,MAP3K1,MAPKKK1|MEKK|MEKK1,,Q13233,,,,,,,,Mitogen-activated protein kinase kinase kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100033,"[""L747-E749del and P750 in EGFR(L747-E749del, A750P)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100033,,,,,,,,,,,,,,,,,,,,,,,,,,,,"L747-E749del and P750 in EGFR(L747-E749del, A750P)",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000977,"[""ovary cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000977,,,,,,,BrendaTissueOBO,,BTO:0000977,,,,,,,,,,,,,,,,,,,ovary cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100008,"[""Activated cdc42 kinase 1""]",,"An activated CDC42 kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q07912] |activated cdc42 kinase 1 (TNK2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300118,,,,,,,,"An activated CDC42 kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q07912] |activated cdc42 kinase 1 (TNK2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100008,,,,https://pharos.nih.gov/idg/targets/Q07912,,,,,,,,,,,,,TNK2,ACK1,,Q07912,,,,,,,,Activated cdc42 kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13636,"[""Fanconi anemia""]",,"A congenital hypoplastic anemia characterized by progressive pancytopenia with bone marrow failure, variable congenital malformations and predisposition to develop hematological or solid tumors. It is a result of a genetic defect in a cluster of proteins responsible for DNA repair.",false,,,http://purl.obolibrary.org/obo/DOID_1342,,,,,,,,"A congenital hypoplastic anemia characterized by progressive pancytopenia with bone marrow failure, variable congenital malformations and predisposition to develop hematological or solid tumors. It is a result of a genetic defect in a cluster of proteins responsible for DNA repair.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13636,,,,OMIM:616435|OMIM:617243|OMIM:617244|OMIM:617247|OMIM:603467|OMIM:300514|OMIM:609053|OMIM:227650|OMIM:613951|OMIM:614083|OMIM:614082|OMIM:610832|NCI:C62505|OMIM:600901|OMIM:605724|OMIM:613390|SNOMEDCT_US_2016_03_01:30575002|UMLS_CUI:C0015625|ICD10CM:D61.09|OMIM:615272|MESH:D005199|OMIM:227646|OMIM:227645|ORDO:84|OMIM:609054,Fanconi's anemia|Fanconi panmyelopathy|Fanconi pancytopenia,,disease_ontology,,DOID:13636,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].
OMIM mapping by NeuroDevNet. [LS].",,Fanconi anemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200484,"[""OR1E1 gene""]",,"An olfactory receptor 1E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30953] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30953] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200484,,,,,,,,,,,,,,,,8387,OR1E1,OR1E5|OR1E6|OR1E9P,,,,,,,,,,OR1E1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200472,"[""OPN1SW gene""]",,"A short-wave-sensitive opsin 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P03999] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A short-wave-sensitive opsin 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P03999] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200472,,,,,,,,,,,,,,,,611,OPN1SW,BCP,,,,,,,,,,OPN1SW gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9669,"[""senile cataract""]",,,false,,,http://purl.obolibrary.org/obo/DOID_83,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9669,,,,SNOMEDCT_US_2016_03_01:193594009|SNOMEDCT_US_2016_03_01:155127007|UMLS_CUI:C0036646|NCI:C35012|ICD9CM:366.1|ICD10CM:H25|SNOMEDCT_US_2016_03_01:193583005|ICD9CM:366.10|SNOMEDCT_US_2016_03_01:193582000|SNOMEDCT_US_2016_03_01:39450006,,,disease_ontology,,DOID:9669,,,,,,,,,,,,,,,,,,,senile cataract,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100574,"[""Ethanolamine kinase 2""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100574,,,,,,,,,,,,,,,,,ETNK2,,,Q9NVF9,,,,,,,,Ethanolamine kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004731,"[""lymphoid progenitor cell""]",,"One of the two stem cells derived from hematopoietic stem cells, the other being the myeloid progenitor cell. Derived from these myeloid progenitor cells are the erythroid progenitor cells and the myeloid cells.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"One of the two stem cells derived from hematopoietic stem cells, the other being the myeloid progenitor cell. Derived from these myeloid progenitor cells are the erythroid progenitor cells and the myeloid cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004731,mgr,2010-08-20T09:36:51Z,,,,,BrendaTissueOBO,,BTO:0004731,,,,,,,,,,,,,,,,,,,lymphoid progenitor cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200003,"[""PRKAG1 gene""]",,"The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400116,,,,,,,,"The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200003,,,,,,,,,,,,,,,,5571,PRKAG1,,,,,,,,,,,PRKAG1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300130,"[""AUR family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300130,,,,,,,,,,,,,,,,,,,,,,,,,,,,AUR family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100247,"[""Protein kinase c zeta type""]",,"A protein kinase C zeta type that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q05513] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300279,,,,,,,,"A protein kinase C zeta type that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q05513] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100247,,,,https://pharos.nih.gov/idg/targets/Q05513,,,,,,,,,,,,,PRKCZ,PKC2,,Q05513,,,,,,,,Protein kinase c zeta type,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400544,"[""Kv3.4/KCNC4 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400443,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400544,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv3.4/KCNC4 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_48432,"[""angiotensin II""]","ang II|Angiotonin|1-8-angiotensin I|Angiotensin II (mouse)|angiotensinum II|Asp-arg-val-TYR-ile-his-pro-phe|Angiotensin II (human)|Angiotensin 2|1-L-Aspasaginyl-5-L-valyl angiotensin octapeptide|Human angiotensin II|Hypertensin|
(3S)-3-amino-3-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S,2S)-1-{[(2S)-1-[(2S)-2-{[(1S)-1-carboxy-2-phenylethyl]carbamoyl}pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]carbamoyl}-2-methylbutyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(diaminomethylidene)amino]butyl]carbamoyl}propanoic acid
|.|Ile(5)-angiotensin II|angiotensina II",,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,CiteXplore:18562510|CiteXplore:12609766|Wikipedia:Angiotensin II|ChemIDplus:11128-99-7|CiteXplore:1422942|HMDB:HMDB01035|CiteXplore:16601568|CiteXplore:16672146|CiteXplore:16481883|CiteXplore:17147923|CiteXplore:16075377,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,"ang II|Angiotonin|1-8-angiotensin I|Angiotensin II (mouse)|angiotensinum II|Asp-arg-val-TYR-ile-his-pro-phe|Angiotensin II (human)|Angiotensin 2|1-L-Aspasaginyl-5-L-valyl angiotensin octapeptide|Human angiotensin II|Hypertensin|
(3S)-3-amino-3-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S,2S)-1-{[(2S)-1-[(2S)-2-{[(1S)-1-carboxy-2-phenylethyl]carbamoyl}pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]carbamoyl}-2-methylbutyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(diaminomethylidene)amino]butyl]carbamoyl}propanoic acid
|.|Ile(5)-angiotensin II|angiotensina II",,,CHEBI:48432,,,,,,,,,,,,,,,,,,,,,,,CHEBI:48432,,,,,angiotensin II|Angiotensin II,,CHEBI:48432,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400040,"[""Free fatty acid receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400040,,,,,,,,,,,,,,,,,,,,,,,,,,,,Free fatty acid receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003452,"[""adipocyte cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003452,,,,,,,BrendaTissueOBO,lipocyte cell line,BTO:0003452,,,,,,,,,,,,,,,,,,,adipocyte cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200393,"[""PCK2 gene""]",,"This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03491022,,,,,,,,"This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200393,,,,,,,,,,,,,,,,5106,PCK2,PEPCK2,,,,,,,,,,PCK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100449,"[""Olfactory receptor 5al1""]",,"An olfactory receptor 5AL1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C617] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5AL1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C617] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100449,,,,https://pharos.nih.gov/idg/targets/P0C617,,,,,,,,,,,,,OR5AL1,OR5AL1P,,P0C617,,,,,,,,Olfactory receptor 5al1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000365,"[""duodenum""]",,The first part of the small intestine extending from the pylorus to the jejunum.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,,The first part of the small intestine extending from the pylorus to the jejunum.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000365,,,,,,,BrendaTissueOBO,anterior intestine|upper intestine|proximal intestine,BTO:0000365,,,,,,,,,,,,,,,,,,,duodenum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400117,"[""ABL family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400117,,,,,,,,,,,,,,,,,,,,,,,,,,,,ABL family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001542,"[""mesonephron""]",,"The excretory organ of the embryo, arising caudal to the pronephros or pronephric rudiments and using its duct; it consists of a long tube in the lower part of the body cavity, running parallel with the vertebral axis and joined at right angles by a row of twisting tubes.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The excretory organ of the embryo, arising caudal to the pronephros or pronephric rudiments and using its duct; it consists of a long tube in the lower part of the body cavity, running parallel with the vertebral axis and joined at right angles by a row of twisting tubes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001542,,,,,,,BrendaTissueOBO,corpus Wolffi|mesonephros|middle kidney|wolffian body|mesonephric kidney,BTO:0001542,,,,,,,,,,,,,,,,,,,mesonephron,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00200000,"[""Gene""]",,"A genomic sequence, which is the unit of heredity of a living organism. It consists of regulatory regions and transcribed regions.",false,,,http://www.w3.org/2002/07/owl#Thing,,,,,,,,"A genomic sequence, which is the unit of heredity of a living organism. It consists of regulatory regions and transcribed regions.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00200000,,,,,,,,,,,,,,,,,,,,,,,,,,,,Gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400252,"[""STKR Type 2 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400119,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400252,,,,,,,,,,,,,,,,,,,,,,,,,,,,STKR Type 2 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200065,"[""CELSR2 gene""]",,"A cadherin EGF LAG seven-pass G-type receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HCU4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400032,,,,,,,,"A cadherin EGF LAG seven-pass G-type receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HCU4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200065,,,,,,,,,,,,,,,,1952,CELSR2,CDHF10|EGFL2|KIAA0279|MEGF3,,,,,,,,,,CELSR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003724,"[""RT-112 cell""]",,Human urinary bladder transitional cell carcinoma established from the transitional cell carcinoma histological grade G2 excised from a female patient with untreated primary urinary bladder carcinoma in 1973.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002868,,,,,,,,Human urinary bladder transitional cell carcinoma established from the transitional cell carcinoma histological grade G2 excised from a female patient with untreated primary urinary bladder carcinoma in 1973.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003724,,,,,,,BrendaTissueOBO,RT 112 cell|RT112 cell,BTO:0003724,,,,,,,,,,,,,,,,,,,RT-112 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060413,"[""chromosome 22q11.2 deletion syndrome, distal""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060388,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060413,elvira,2015-09-28T17:28:28Z,,ORDO:261330|OMIM:611867,distal 22q11.2 microdeletion syndrome,,disease_ontology,,DOID:0060413,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,"chromosome 22q11.2 deletion syndrome, distal",,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060410,"[""chromosome 1p36 deletion syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060388,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060410,elvira,2015-09-28T17:14:10Z,,UMLS_CUI:C1842870|NCI:C74983|MESH:C535362|ORDO:1606|OMIM:607872|SNOMEDCT_US_2016_03_01:699306003,monosomy 1p36|deletion 1p36|1p36 deletion syndrome,,disease_ontology,subtelomeric 1p36 deletion,DOID:0060410,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,chromosome 1p36 deletion syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060417,"[""3p- syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060388,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060417,elvira,2015-09-28T17:38:32Z,,ORDO:1620|OMIM:613792|ICD10CM:Q93.5,distal monosomy 3p|chromosome 3pter-P25 deletion syndrome,,disease_ontology,,DOID:0060417,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,3p- syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060415,"[""chromosome 2p16.1-p15 deletion syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060388,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060415,elvira,2015-09-28T17:32:44Z,,ORDO:261349|OMIM:612513|ICD10CM:Q93.5,2p15p16.1 microdeletion syndrome,,disease_ontology,2p15-p16.1 microdeletion syndrome,DOID:0060415,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,chromosome 2p16.1-p15 deletion syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200541,"[""OR2M4 gene""]",,"An olfactory receptor 2M4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R27] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2M4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R27] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200541,,,,,,,,,,,,,,,,26245,OR2M4,,,,,,,,,,,OR2M4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200316,"[""OR10J6P gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200316,,,,,,,,,,,,,,,,401973,OR10J6P,OR10J6,,,,,,,,,,OR10J6P gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000405,"[""THR790 in EGFR(T790M)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000405,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR790 in EGFR(T790M),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00000008,"[""Tdark protein""]",,"Tdark refers to proteins that have been described at the sequence level and have very few associated studies. They do not have any known drug or small molecule activities that satisfy the activity thresholds detailed in 2), lack OMIM and GO terms that would match Tbio criteria, and meet at least two of the following conditions: 1)A PubMed text-mining score < 5; 2) < = 3 Gene RIFs; 3)<= 50 Antibodies available according to http://antibodypedia.com",false,,,http://www.w3.org/2002/07/owl#Thing,,,,,,,,"Tdark refers to proteins that have been described at the sequence level and have very few associated studies. They do not have any known drug or small molecule activities that satisfy the activity thresholds detailed in 2), lack OMIM and GO terms that would match Tbio criteria, and meet at least two of the following conditions: 1)A PubMed text-mining score < 5; 2) < = 3 Gene RIFs; 3)<= 50 Antibodies available according to http://antibodypedia.com",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00000008,,,,,,,,,,,,,,,,,,,,,,,,,,,IDG; http://www.nature.com/nrd/posters/druggablegenome/nrd_druggablegenome.pdf,Tdark protein,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001849,"[""urinary bladder smooth muscle""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001260,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001849,,,,,,,BrendaTissueOBO,,BTO:0001849,,,,,,,,,,,,,,,,,,,urinary bladder smooth muscle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000062,"[""PrRP-20""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000062,,,,,,,,,,,,,,,,,,,,,,,,,,,,PrRP-20,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400106,"[""TK group gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400102,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,TK group gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004997,"[""non-myelinating Schwann cell""]",,A variety of glial cell that keep unmyelinated peripheral nerve fibres alive.,false,,,http://purl.obolibrary.org/obo/BTO_0001220|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A variety of glial cell that keep unmyelinated peripheral nerve fibres alive.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004997,XPMUser,2011-02-26T05:35:28Z,,,,,BrendaTissueOBO,nonmyelinating Schwann cell,BTO:0004997,,,,,,,,,,,,,,,,,,,non-myelinating Schwann cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004787,"[""SK-N-LO cell""]",,Ewing's sarcoma family tumor cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0004785,,,,,,,,Ewing's sarcoma family tumor cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004787,mgr,2010-10-04T09:52:54Z,,,,,BrendaTissueOBO,,BTO:0004787,,,,,,,,,,,,,,,,,,,SK-N-LO cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100215,"[""Potassium channel subfamily K member 3""]",,"A potassium channel subfamily K member 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14649] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300359,,,,,,,,"A potassium channel subfamily K member 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14649] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100215,,,,https://pharos.nih.gov/idg/targets/O14649,,,,,,,,,,,,,KCNK3,TASK|TASK1,,O14649,,,,,,,,Potassium channel subfamily K member 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002775,"[""ANA-1 cell""]",,The ANA-1 immortalized murine macrophage cell line was established by infecting the normal bone marrow of C57BL/6 mice with the murine recombinant 52 retrovirus (expressing the v-raf and v-myc oncogenes).,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002278|http://purl.obolibrary.org/obo/BTO_0000264,,,,,,,,The ANA-1 immortalized murine macrophage cell line was established by infecting the normal bone marrow of C57BL/6 mice with the murine recombinant 52 retrovirus (expressing the v-raf and v-myc oncogenes).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002775,,,,,,,BrendaTissueOBO,,BTO:0002775,,,,,,,,,,,,,,,,,,,ANA-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_16325,"[""lithocholic acid""]","5beta-cholanic acid-3alpha-ol|[H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@]([H])(CC[C@@]34[H])[C@H](C)CCC(O)=O)[C@@]1(C)CC[C@@H](O)C2|376.298|3alpha-Hydroxy-5beta-cholanate|3alpha-hydroxy-5beta-cholanic acid|3alpha-hydroxy-5beta-cholanoic acid|SMEROWZSTRWXGI-HVATVPOCSA-N|(3alpha,5beta)-3-hydroxycholan-24-oic acid|376.57260|3alpha-Hydroxy-5beta-cholanic acid|InChI=1S/C24H40O3/c1-15(4-9-22(26)27)19-7-8-20-18-6-5-16-14-17(25)10-12-23(16,2)21(18)11-13-24(19,20)3/h15-21,25H,4-14H2,1-3H3,(H,26,27)/t15-,16-,17-,18+,19-,20+,21+,23+,24-/m1/s1|0|C24H40O3",A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.,false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,PMID:24332653|HMDB:HMDB00761|Wikipedia:Lithocholic_acid|PMID:24399466|Reaxys:3217757|PDBeChem:4OA|PMID:24270587|LINCS:LSM-5371|MetaCyc:CPD-7235|PMID:23639599|KEGG:C03990|Beilstein:3217757|CAS:434-13-9|LIPID_MAPS_instance:LMST04010003|PMID:7068113,A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:1711|CHEBI:20239|CHEBI:20238,,3alpha-hydroxy-5beta-cholan-24-oic acid|Lithocholic acid,,chebi_ontology,"5beta-cholanic acid-3alpha-ol|[H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@]([H])(CC[C@@]34[H])[C@H](C)CCC(O)=O)[C@@]1(C)CC[C@@H](O)C2|376.298|3alpha-Hydroxy-5beta-cholanate|3alpha-hydroxy-5beta-cholanic acid|3alpha-hydroxy-5beta-cholanoic acid|SMEROWZSTRWXGI-HVATVPOCSA-N|(3alpha,5beta)-3-hydroxycholan-24-oic acid|376.57260|3alpha-Hydroxy-5beta-cholanic acid|InChI=1S/C24H40O3/c1-15(4-9-22(26)27)19-7-8-20-18-6-5-16-14-17(25)10-12-23(16,2)21(18)11-13-24(19,20)3/h15-21,25H,4-14H2,1-3H3,(H,26,27)/t15-,16-,17-,18+,19-,20+,21+,23+,24-/m1/s1|0|C24H40O3",,,CHEBI:16325,,,,,,,,,,,,,,,,,,,,,,,CHEBI:16325,,,,,lithocholic acid,,CHEBI:16325,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005492,"[""MT-2 cell""]",,"Human lymphoblastic T-lymphocyte cell line, carrying the human T-cell leukemia virus type I.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001045,,,,,,,,"Human lymphoblastic T-lymphocyte cell line, carrying the human T-cell leukemia virus type I.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005492,XPMUser,2013-09-11T09:05:17Z,,,,,BrendaTissueOBO,MT2 cell,BTO:0005492,,,,,,,,,,,,,,,,,,,MT-2 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400480,"[""SCNN1G subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400330,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400480,,,,,,,,,,,,,,,,,,,,,,,,,,,,SCNN1G subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200588,"[""OR4F5 gene""]",,"An olfactory receptor 4F5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH21] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4F5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH21] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200588,,,,,,,,,,,,,,,,79501,OR4F5,,,,,,,,,,,OR4F5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000156,"[""CXCL6""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000156,,,,,,,,,,,,,,,,,,,,,,,,,,,,CXCL6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100001,"[""Ap2-associated protein kinase 1""]",,"An AP2-associated protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q2M2I8] |AP2-associated protein kinase 1 (AAK1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300115,,,,,,,,"An AP2-associated protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q2M2I8] |AP2-associated protein kinase 1 (AAK1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100001,,,,https://pharos.nih.gov/idg/targets/Q2M2I8,,,,,,,,,,,,,AAK1,KIAA1048,,Q2M2I8,,,,,,,,Ap2-associated protein kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200454,"[""GRK1 gene""]",,"This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400271,,,,,,,,"This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200454,,,,,,,,,,,,,,,,6011,GRK1,RHOK,,,,,,,,,,GRK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200330,"[""OR11H1 gene""]",,"An olfactory receptor 11H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG94] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 11H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG94] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200330,,,,,,,,,,,,,,,,81061,OR11H1,,,,,,,,,,,OR11H1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100349,"[""Olfactory receptor 13H1""]",,"An olfactory receptor 13H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG92] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 13H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG92] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100349,,,,https://pharos.nih.gov/idg/targets/Q8NG92,,,,,,,,,,,,,OR13H1,,,Q8NG92,,,,,,,,Olfactory receptor 13H1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000813,"[""Pt-K1 cell""]",,"Marsupial - potoroo, kidney cell line.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000067,,,,,,,,"Marsupial - potoroo, kidney cell line.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000813,,,,,,,BrendaTissueOBO,Pt K1 cell,BTO:0000813,,,,,,,,,,,,,,,,,,,Pt-K1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300320,"[""HH498 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300165,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300320,,,,,,,,,,,,,,,,,,,,,,,,,,,,HH498 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003659,"[""secretory cell""]",,"Cell specialised for secretion, usually epithelial. Those that secrete proteins characteristically have well developed rough endoplasmic reticulum, whereas conspicuous smooth endoplasmic reticulum is typical of cells that secrete lipid or lipid derived products (e.g. Steroids).",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000522,,,,,,,,"Cell specialised for secretion, usually epithelial. Those that secrete proteins characteristically have well developed rough endoplasmic reticulum, whereas conspicuous smooth endoplasmic reticulum is typical of cells that secrete lipid or lipid derived products (e.g. Steroids).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003659,,,,,,,BrendaTissueOBO,,BTO:0003659,,,,,,,,,,,,,,,,,,,secretory cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001677,"[""SCHNEIDER-2 cell""]",,"Insect - fruitfly (Drosophila melanogaster) cell line, established from the late embryo of a Drosophila melanogaster (fruitfly) in 1972; originally the cells were diploid with 5-10% XY, currently the cell line has only XX cells that are now 60-80% tetraploid.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000669,,,,,,,,"Insect - fruitfly (Drosophila melanogaster) cell line, established from the late embryo of a Drosophila melanogaster (fruitfly) in 1972; originally the cells were diploid with 5-10% XY, currently the cell line has only XX cells that are now 60-80% tetraploid.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001677,,,,,,,BrendaTissueOBO,SL-2 cell|Schneider cell|S2 cell|SCHNEIDER S2 Cell|SL2 cell|Schneider's Line S2 cell|S-2 cell,BTO:0001677,,,,,,,,,,,,,,,,,,,SCHNEIDER-2 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000484,"[""frontal lobe""]",,"Front part of the brain, involved in planning, organizing, problem solving, selective attention, personality and a variety of higher cognitive functions including behavior and emotions.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Front part of the brain, involved in planning, organizing, problem solving, selective attention, personality and a variety of higher cognitive functions including behavior and emotions.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000484,,,,,,,BrendaTissueOBO,frontal cortex,BTO:0000484,,,,,,,,,,,,,,,,,,,frontal lobe,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200297,"[""SCN5A gene""]",,"The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400471,,,,,,,,"The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200297,,,,,,,,,,,,,,,,6331,SCN5A,,,,,,,,,,,SCN5A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001656,"[""nerve cord""]",,1. The pair of closely united ventral longitudinal nerves with their segmental ganglia that is characteristic of many elongate invertebrates (as earthworms). 2. The dorsal tubular cord of nervous tissue above the notochord of a chordate that comprises or develops into the central nervous system.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,1. The pair of closely united ventral longitudinal nerves with their segmental ganglia that is characteristic of many elongate invertebrates (as earthworms). 2. The dorsal tubular cord of nervous tissue above the notochord of a chordate that comprises or develops into the central nervous system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001656,,,,,,,BrendaTissueOBO,,BTO:0001656,,,,,,,,,,,,,,,,,,,nerve cord,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217466,"[""Vitamin d receptor-like receptors gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00200002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217466,,,,,,,,,,,,,,,,,,,,,,,,,,,,Vitamin d receptor-like receptors gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005755,"[""choroid plexus papilloma cell""]",,"Choroid plexus papillomas are an uncommon, benign neuroepithelial intraventricular tumour which can occur in both the paediatric and adult population.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0005754,,,,,,,,"Choroid plexus papillomas are an uncommon, benign neuroepithelial intraventricular tumour which can occur in both the paediatric and adult population.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005755,Marion,2015-09-13T14:01:16Z,,,,,BrendaTissueOBO,CPP cell,BTO:0005755,,,,,,,,,,,,,,,,,,,choroid plexus papilloma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004398,"[""meningioma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004398,Marion,2010-02-01T09:41:16Z,,,,,BrendaTissueOBO,,BTO:0004398,,,,,,,,,,,,,,,,,,,meningioma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400247,"[""ABC1-B subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400120,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400247,,,,,,,,,,,,,,,,,,,,,,,,,,,,ABC1-B subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_30011,"[""L-glutamine residue""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_33700,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:30011,,,,RESID:AA0007,L-glutamine residue,,chebi_ontology,Gln|Q|C5H8N2O2|L-glutamine|128.059|128.12930|Glu(NH2)|-Gln-|L-glutaminyl|0,CHEBI:30011,http://purl.obolibrary.org/obo/chebi#3_STAR,,,,,,,,,,,,,,,,,,L-glutamine residue,,,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200754,"[""PTH1R gene""]",,"A parathyroid hormone/parathyroid hormone-related peptide receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q03431] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400084|http://www.drugtargetontology.org/dto/DTO_02400003,,,,,,,,"A parathyroid hormone/parathyroid hormone-related peptide receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q03431] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200754,,,,,,,,,,,,,,,,5745,PTH1R,PTHR|PTHR1,,,,,,,,,,PTH1R gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_7165,"[""subacute thyroiditis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_7166,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:7165,,,,NCI:C35071|UMLS_CUI:C0040149|SNOMEDCT_US_2016_03_01:237530000|MESH:D013968|SNOMEDCT_US_2016_03_01:237531001|ICD10CM:E06.1|SNOMEDCT_US_2016_03_01:190296009|SNOMEDCT_US_2016_03_01:237533003|SNOMEDCT_US_2016_03_01:237532008|ICD9CM:245.1|NCI:C35828|SNOMEDCT_US_2016_03_01:38727009|SNOMEDCT_US_2016_03_01:154666006|SNOMEDCT_US_2016_03_01:428041004,Subacute thyroiditis (disorder)|de Quervain's thyroiditis|Giant-cell thyroiditis|Subacute Thyroiditis|De Quervain's thyroiditis|Subacute Granulomatous Thyroiditis|Granulomatous thyroiditis,,disease_ontology,,DOID:7165,,,,,,,,,,,,,,,,,,,subacute thyroiditis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100151,"[""Probable G-protein coupled receptor 148""]",,"A G-protein coupled receptor 148 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDV2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 148 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDV2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100151,,,,https://pharos.nih.gov/idg/targets/Q8TDV2,,,,,,,,,,,,,GPR148,BTR|PGR6,,Q8TDV2,,,,,,,,Probable G-protein coupled receptor 148,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100164,"[""Glycogen synthase kinase-3 alpha""]",,"A glycogen synthase kinase-3 alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49840] |glycogen synthase kinase-3 alpha (GSK3A)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300272,,,,,,,,"A glycogen synthase kinase-3 alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49840] |glycogen synthase kinase-3 alpha (GSK3A)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100164,,,,https://pharos.nih.gov/idg/targets/P49840,,,,,,,,,,,,,GSK3A,,,P49840,,,,,,,,Glycogen synthase kinase-3 alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300577,"[""TRPC1 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300482,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300577,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPC1 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_30009,"[""L-isoleucine residue""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_33700,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:30009,,,,RESID:AA0010,L-isoleucine residue,,chebi_ontology,-Ile-|Ile|113.084|C6H11NO|L-isoleucyl|113.15768|0|I|L-isoleucine,CHEBI:30009,http://purl.obolibrary.org/obo/chebi#3_STAR,,,,,,,,,,,,,,,,,,L-isoleucine residue,,,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000947,"[""neuronal cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000947,,,,,,,BrendaTissueOBO,,BTO:0000947,,,,,,,,,,,,,,,,,,,neuronal cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001176,"[""endothelial cell""]",,"The main type of cell found in the inside lining of blood vessels, lymph vessels, and the heart.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The main type of cell found in the inside lining of blood vessels, lymph vessels, and the heart.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001176,,,,,,,BrendaTissueOBO,,BTO:0001176,,,,,,,,,,,,,,,,,,,endothelial cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300159,"[""GSK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300111,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300159,,,,,,,,,,,,,,,,,,,,,,,,,,,,GSK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400173,"[""PKG family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400173,,,,,,,,,,,,,,,,,,,,,,,,,,,,PKG family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200362,"[""OR2AG1 gene""]",,"An olfactory receptor 2AG1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H205] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2AG1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H205] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200362,,,,,,,,,,,,,,,,144125,OR2AG1,OR2AG3,,,,,,,,,,OR2AG1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200031,"[""ADRA2B gene""]",,"An alpha-2B adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P18089] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400093,,,,,,,,"An alpha-2B adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P18089] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200031,,,,,,,,,,,,,,,,151,ADRA2B,ADRA2L1|ADRA2RL1,,,,,,,,,,ADRA2B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000283,"[""PHE80 in CDK3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000283,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE80 in CDK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200043,"[""BMPR2 gene""]",,"This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400252,,,,,,,,"This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200043,,,,,,,,,,,,,,,,659,BMPR2,PPH1,,,,,,,,,,BMPR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200097,"[""CIT gene""]",,"This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400145,,,,,,,,"This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200097,,,,,,,,,,,,,,,,11113,CIT,CRIK|KIAA0949|STK21,,,,,,,,,,CIT gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8025,"[""gastric signet ring cell adenocarcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_6217,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8025,,,,UMLS_CUI:C1335965|NCI:C5250,Signet Ring cell adenocarcinoma of the stomach,,disease_ontology,,DOID:8025,,,,,,,,,,,,,,,,,,,gastric signet ring cell adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200427,"[""OR52L1 gene""]",,"An olfactory receptor 52L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 52L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200427,,,,,,,,,,,,,,,,338751,OR52L1,,,,,,,,,,,OR52L1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400496,"[""Alpha-7/CHRNA7 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400496,,,,,,,,,,,,,,,,,,,,,,,,,,,,Alpha-7/CHRNA7 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200302,"[""MARK1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400290,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200302,,,,,,,,,,,,,,,,4139,MARK1,KIAA1477|MARK,,,,,,,,,,MARK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300239,"[""TTBK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300112,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300239,,,,,,,,,,,,,,,,,,,,,,,,,,,,TTBK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000122,"[""bile duct""]",,Any of the ducts that convey bile in and from the liver.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Any of the ducts that convey bile in and from the liver.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000122,,,,,,,BrendaTissueOBO,gall duct|biliary duct,BTO:0000122,,,,,,,,,,,,,,,,,,,bile duct,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_28209,"[""5(S)-HETE""]","(6E,8Z,11Z,14Z)-(5S)-5-Hydroxyicosa-6,8,11,14-tetraenoic acid|5S-HETE|5(S)-hydroxyeicosatetraenoic acid|6,8,11,14-Eicosatetraenoic acid, 5-hydroxy-, (S-(E,Z,Z,Z))-|320.46628|(5S,6E,8Z,11Z,14Z)-5-hydroxyeicosa-6,8,11,14-tetraenoic acid|KGIJOOYOSFUGPC-JGKLHWIESA-N|320.235|(S)-(E,Z,Z,Z)-5-hydroxyeicosa-6,8,11,14-tetraenoic acid|InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h6-7,9-10,12-14,16,19,21H,2-5,8,11,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1|0|5-Hydroxyeicosatetraenoate|CCCCC\C=C/C\C=C/C\C=C/C=C/[C@@H](O)CCCC(O)=O|C20H32O3|5(S)-hydroxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid","A HETE having a (5S)-hydroxy group and (6E)-, (8Z)-, (11Z)- and (14Z)-double bonds.",false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,Reaxys:4691533|CAS:70608-72-9|Wikipedia:5-Hydroxyeicosatetraenoic_acid|LIPID_MAPS_instance:LMFA03060002|Beilstein:4691533|PMID:3460103|KEGG:C04805|PMID:3592413|HMDB:HMDB11134|PMID:10987416|KNApSAcK:C00000423,"A HETE having a (5S)-hydroxy group and (6E)-, (8Z)-, (11Z)- and (14Z)-double bonds.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:20581|CHEBI:2068,,"5(S)-HETE|(5S,6E,8Z,11Z,14Z)-5-hydroxyicosa-6,8,11,14-tetraenoic acid",,chebi_ontology,"(6E,8Z,11Z,14Z)-(5S)-5-Hydroxyicosa-6,8,11,14-tetraenoic acid|5S-HETE|5(S)-hydroxyeicosatetraenoic acid|6,8,11,14-Eicosatetraenoic acid, 5-hydroxy-, (S-(E,Z,Z,Z))-|320.46628|(5S,6E,8Z,11Z,14Z)-5-hydroxyeicosa-6,8,11,14-tetraenoic acid|KGIJOOYOSFUGPC-JGKLHWIESA-N|320.235|(S)-(E,Z,Z,Z)-5-hydroxyeicosa-6,8,11,14-tetraenoic acid|InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h6-7,9-10,12-14,16,19,21H,2-5,8,11,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1|0|5-Hydroxyeicosatetraenoate|CCCCC\C=C/C\C=C/C\C=C/C=C/[C@@H](O)CCCC(O)=O|C20H32O3|5(S)-hydroxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid",,,CHEBI:28209,,,,,,,,,,,,,,,,,,,,,,,CHEBI:28209,,,,,5(S)-HETE,,CHEBI:28209,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200174,"[""HIPK3 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400273,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200174,,,,,,,,,,,,,,,,10114,HIPK3,DYRK6|FIST3|PKY,,,,,,,,,,HIPK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100343,"[""Serine/threonine-protein kinase mrck gamma""]",,"serine/threonine-protein kinase mrck gamma (DMPK2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase MRCK gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6DT37] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300265,,,,,,,,"serine/threonine-protein kinase mrck gamma (DMPK2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase MRCK gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6DT37] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100343,,,,https://pharos.nih.gov/idg/targets/Q6DT37,,,,,,,,,,,,,CDC42BPG,DMPK2,,Q6DT37,,,,,,,,Serine/threonine-protein kinase mrck gamma,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000125,"[""EGFR(L747-S752del, P753S) kinase domain""]",,"Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000125,,,,,,,,,,,,,,,,,,,200127,,,,,,,,,"EGFR(L747-S752del, P753S) kinase domain",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001088,"[""gastric cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001088,,,,,,,BrendaTissueOBO,,BTO:0001088,,,,,,,,,,,,,,,,,,,gastric cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200675,"[""OR7A5 gene""]",,"An olfactory receptor 7A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15622] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 7A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15622] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200675,,,,,,,,,,,,,,,,26659,OR7A5,,,,,,,,,,,OR7A5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000152,"[""CCL2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000152,,,,,,,,,,,,,,,,,,,,,,,,,,,,CCL2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4329,"[""Erdheim-Chester disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4330,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4329,,,,UMLS_CUI:C0878675|SNOMEDCT_US_2016_03_01:699537002|SNOMEDCT_US_2016_03_01:703711007|NCI:C53972|MESH:D031249,,,disease_ontology,,DOID:4329,,,,,,,,,,,,,,,,,,,Erdheim-Chester disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100379,"[""Olfactory receptor 4c45""]",,"An olfactory receptor 4C45 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NMZ5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4C45 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NMZ5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100379,,,,https://pharos.nih.gov/idg/targets/A6NMZ5,,,,,,,,,,,,,OR4C45,,,A6NMZ5,,,,,,,,Olfactory receptor 4c45,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100256,"[""Melanin-concentrating hormone receptor 2""]",,"A melanin-concentrating hormone receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q969V1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300052,,,,,,,,"A melanin-concentrating hormone receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q969V1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100256,,,,https://pharos.nih.gov/idg/targets/Q969V1,,,,,,,,,,,,,MCHR2,GPR145|SLT,,Q969V1,,,,,,,,Melanin-concentrating hormone receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100272,"[""Leucine-rich repeat serine/threonine-protein kinase 1""]",,"A leucine-rich repeat serine/threonine-protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q38SD2] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300184,,,,,,,,"A leucine-rich repeat serine/threonine-protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q38SD2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100272,,,,https://pharos.nih.gov/idg/targets/Q38SD2,,,,,,,,,,,,,LRRK1,KIAA1790,,Q38SD2,,,,,,,,Leucine-rich repeat serine/threonine-protein kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000230,"[""KPCL kinase domain""]",,"Protein kinase C, eta; MGC26269; MGC5363; nPKC-eta; PKCL; PKC-L; PRKCH; PRKCL",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Protein kinase C, eta; MGC26269; MGC5363; nPKC-eta; PKCL; PKC-L; PRKCH; PRKCL",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000230,,,,,,,,,,,,,,,,,,,200356,,,,,,,,,KPCL kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4223,"[""pyoderma""]",,Pyoderma is a skin infectious disease where the infection is pyogenic causing the formation of pus.,false,,,http://purl.obolibrary.org/obo/DOID_2723,,,,,,,,Pyoderma is a skin infectious disease where the infection is pyogenic causing the formation of pus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4223,,,,SNOMEDCT_US_2016_03_01:156323008|MESH:D011711|ICD10CM:L08.0|SNOMEDCT_US_2016_03_01:267838007|SNOMEDCT_US_2016_03_01:200719000|ICD9CM:686.00|SNOMEDCT_US_2016_03_01:70759006|UMLS_CUI:C0034212|ICD9CM:686.0,,,disease_ontology,,DOID:4223,,,,,,,,,,,,,,,,,,,pyoderma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000132,"[""MET150 in NIM1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000132,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET150 in NIM1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001620,"[""SK-N-SH cell""]",,"Human, Caucasian, bone marrow, neuroblastoma cell line. Species: human, Caucasian female 4 years old; Tissue: bone marrow; Tumor: neuroblastoma.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000932,,,,,,,,"Human, Caucasian, bone marrow, neuroblastoma cell line. Species: human, Caucasian female 4 years old; Tissue: bone marrow; Tumor: neuroblastoma.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001620,,,,,,,BrendaTissueOBO,,BTO:0001620,,,,,,,,,,,,,,,,,,,SK-N-SH cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200144,"[""HCN1 gene""]",,"The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400343,,,,,,,,"The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200144,,,,,,,,,,,,,,,,348980,HCN1,BCNG1,,,,,,,,,,HCN1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100093,"[""Cation channel sperm-associated protein 1""]",,"A cation channel sperm-associated protein 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8NEC5] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300345,,,,,,,,"A cation channel sperm-associated protein 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8NEC5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100093,,,,https://pharos.nih.gov/idg/targets/Q8NEC5,,,,,,,,,,,,,CATSPER1,,,Q8NEC5,,,,,,,,Cation channel sperm-associated protein 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00500669,"[""Gating mechanism""]",,The mechanism for the inter-conversion of the open-and-closed states of an ion channel.,false,,,http://purl.obolibrary.org/obo/BFO_0000019,,,,,,,,The mechanism for the inter-conversion of the open-and-closed states of an ion channel.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00500669,,,,,,,,,,,,,,,,,,,,,,,,,,,,Gating mechanism,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100266,"[""Motilin receptor""]",,A motilin receptor that is encoded in the genome of human. [Reactome:REACT_21601] ,false,,,http://www.drugtargetontology.org/dto/DTO_02300064,,,,,,,,A motilin receptor that is encoded in the genome of human. [Reactome:REACT_21601] ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100266,,,,https://pharos.nih.gov/idg/targets/O43193,,,,,,,,,,,,,MLNR,GPR38|MTLR|MTLR1,,O43193,,,,,,,,Motilin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200601,"[""AK9 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200601,,,,,,,,,,,,,,,,,,,,,,,,,,,,AK9 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200387,"[""OR51B2 gene""]",,"An olfactory receptor 51B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y5P1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 51B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y5P1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200387,,,,,,,,,,,,,,,,79345,OR51B2,OR51B1P,,,,,,,,,,OR51B2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200719,"[""OR9Q1 gene""]",,"An olfactory receptor 9Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 9Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200719,,,,,,,,,,,,,,,,219956,OR9Q1,,,,,,,,,,,OR9Q1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100517,"[""Olfactory receptor 2B11""]",,"An olfactory receptor 2B11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5JQS5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2B11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5JQS5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100517,,,,https://pharos.nih.gov/idg/targets/Q5JQS5,,,,,,,,,,,,,OR2B11,,,Q5JQS5,,,,,,,,Olfactory receptor 2B11,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002999,"[""22Rv-1 cell""]",,"Human prostate carcinoma cell line; derived from a human prostate carcinoma xenograft (CWR22R) that was serially propagated in nude mice after castration-induced regression and relapse of the parental, androgen-dependent CWR22 xenograft.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Human prostate carcinoma cell line; derived from a human prostate carcinoma xenograft (CWR22R) that was serially propagated in nude mice after castration-induced regression and relapse of the parental, androgen-dependent CWR22 xenograft.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002999,,,,,,,BrendaTissueOBO,CWR22-Rv1 cell|CWR22R-V1 cell|CWR22Rv1 cell|22Rv1 cell,BTO:0002999,,,,,,,,,,,,,,,,,,,22Rv-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400201,"[""PAN3 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400201,,,,,,,,,,,,,,,,,,,,,,,,,,,,PAN3 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300593,"[""TRPV4 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300484,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300593,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPV4 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004086,"[""mammary gland tumor cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0000356|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003568,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004086,,,,,,,BrendaTissueOBO,mammary tumor cell line,BTO:0004086,,,,,,,,,,,,,,,,,,,mammary gland tumor cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002098,"[""tympanum""]",,"The major portion of the middle ear (auris media), consisting of a narrow air-filled cavity in the temporal bone that contains the auditory ossicles. It communicates with the mastoid air cells and the mastoid antrum via the aditus and with the nasopharynx via the auditory tube. The middle ear and the tympanic cavity were formerly regarded as being synonymous.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The major portion of the middle ear (auris media), consisting of a narrow air-filled cavity in the temporal bone that contains the auditory ossicles. It communicates with the mastoid air cells and the mastoid antrum via the aditus and with the nasopharynx via the auditory tube. The middle ear and the tympanic cavity were formerly regarded as being synonymous.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002098,,,,,,,BrendaTissueOBO,tympanic cavity|cavitas tympanica|cavitas tympani,BTO:0002098,,,,,,,,,,,,,,,,,,,tympanum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000127,"[""MET143 in MP2K1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000127,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET143 in MP2K1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200575,"[""GALK2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200575,,,,,,,,,,,,,,,,,,,,,,,,,,,,GALK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300028,"[""Calcitonin receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300003,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300028,,,,,,,,,,,,,,,,,,,,,,,,,,,,Calcitonin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100147,"[""Tyrosine-protein kinase fer""]",,"A tyrosine-protein kinase Fer that is encoded in the genome of human. [PRO:DNx, UniProtKB:P16591] |tyrosine-protein kinase fer (FER)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300157,,,,,,,,"A tyrosine-protein kinase Fer that is encoded in the genome of human. [PRO:DNx, UniProtKB:P16591] |tyrosine-protein kinase fer (FER)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100147,,,,https://pharos.nih.gov/idg/targets/P16591,,,,,,,,,,,,,FER,TYK3,,P16591,,,,,,,,Tyrosine-protein kinase fer,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4347,"[""lymphocele""]",,,false,,,http://purl.obolibrary.org/obo/DOID_75,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4347,,,,SNOMEDCT_US_2016_03_01:234109007|UMLS_CUI:C0024248|MESH:D008210|SNOMEDCT_US_2016_03_01:234110002|NCI:C78442|SNOMEDCT_US_2016_03_01:12167004,Lymph cyst,,disease_ontology,,DOID:4347,,,,,,,,,,,,,,,,,,,lymphocele,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1612,"[""breast cancer""]",,A thoracic cancer that originates in the mammary gland.,false,,,http://purl.obolibrary.org/obo/DOID_3463|http://purl.obolibrary.org/obo/DOID_5093,,,,,,,,A thoracic cancer that originates in the mammary gland.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1612,,,DOID:4241|DOID:1648,ICD10CM:C50|NCI:C2910|ICD10CM:C50-C50|SNOMEDCT_US_2016_03_01:269595005|SNOMEDCT_US_2016_03_01:254837009|UMLS_CUI:C1458155|SNOMEDCT_US_2016_03_01:190121004|MESH:D001943|OMIM:600048|SNOMEDCT_US_2016_03_01:126926005|OMIM:605365|UMLS_CUI:C0153555|OMIM:114480|UMLS_CUI:C0006142|NCI:C9335|ICD9CM:174.8|SNOMEDCT_US_2016_03_01:154521006,mammary cancer|primary breast cancer|malignant tumor of the breast|breast tumor|mammary tumor|malignant neoplasm of breast,,disease_ontology,mammary neoplasm,DOID:1612,http://purl.obolibrary.org/obo/doid#DO_cancer_slim|http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,breast cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000146,"[""XCL1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000146,,,,,,,,,,,,,,,,,,,,,,,,,,,,XCL1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001330,"[""hepatoma ascites cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000608,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001330,,,,,,,BrendaTissueOBO,,BTO:0001330,,,,,,,,,,,,,,,,,,,hepatoma ascites cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002869,"[""transitional cell carcinoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000297,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002869,,,,,,,BrendaTissueOBO,,BTO:0002869,,,,,,,,,,,,,,,,,,,transitional cell carcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100408,"[""Phosphoinositide 3-kinase regulatory subunit 4""]",,"A phosphoinositide 3-kinase regulatory subunit 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99570] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300206,,,,,,,,"A phosphoinositide 3-kinase regulatory subunit 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99570] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100408,,,,https://pharos.nih.gov/idg/targets/Q99570,,,,,,,,,,,,,PIK3R4,,,Q99570,,,,,,,,Phosphoinositide 3-kinase regulatory subunit 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000944,"[""NIH-3T3 cell""]",,"Very widely used mouse fibroblast cell line; 3T3 cells have been derived from different mouse strains and it is therefore important to define the particular cell line. NIH strain were from the National Institute of Health in the USA; Mouse embryonic fibroblast cell line, established from disaggregated Swiss albino mouse embryos in 1962.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001958,,,,,,,,"Very widely used mouse fibroblast cell line; 3T3 cells have been derived from different mouse strains and it is therefore important to define the particular cell line. NIH strain were from the National Institute of Health in the USA; Mouse embryonic fibroblast cell line, established from disaggregated Swiss albino mouse embryos in 1962.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000944,,,,,,,BrendaTissueOBO,3T3 cell|NIH/3T3 cell|NIH 3T3 cell|NIH3T3 cell|3T3 fibroblast|3T3-Swiss albino cell,BTO:0000944,,,,,,,,,,,,,,,,,,,NIH-3T3 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200172,"[""KCNIP1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200172,,,,,,,,,,,,,,,,,KCNIP1,,,,,,,,,,,KCNIP1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100008,"[""5-hydroxytryptamine receptor 2c""]",,"A 5-hydroxytryptamine receptor 2C that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28335] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302002,,,,,,,,"A 5-hydroxytryptamine receptor 2C that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28335] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100008,,,,https://pharos.nih.gov/idg/targets/P28335,,,,,,,,,,,,,HTR2C,HTR1C,,P28335,,,,,,,,5-hydroxytryptamine receptor 2c,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200082,"[""CHEK1 gene""]",,"The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400264,,,,,,,,"The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200082,,,,,,,,,,,,,,,,1111,CHEK1,CHK1,,,,,,,,,,CHEK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400300,"[""NMO subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400191,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400300,,,,,,,,,,,,,,,,,,,,,,,,,,,,NMO subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400285,"[""LZK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400165,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400285,,,,,,,,,,,,,,,,,,,,,,,,,,,,LZK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000243,"[""vagina""]",,A canal in a female mammal that leads from the uterus to the external orifice of the genital canal.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003099,,,,,,,,A canal in a female mammal that leads from the uterus to the external orifice of the genital canal.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000243,,,,,,,BrendaTissueOBO,,BTO:0000243,,,,,,,,,,,,,,,,,,,vagina,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000151,"[""MET225 in AKT3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000151,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET225 in AKT3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100091,"[""Adhesion G protein-coupled receptor E3""]",,"An EGF-like module-containing mucin-like hormone receptor-like 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BY15] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,"An EGF-like module-containing mucin-like hormone receptor-like 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BY15] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100091,,,,https://pharos.nih.gov/idg/targets/Q9BY15,,,,,,,,,,,,,EMR3,ADGRE3,,Q9BY15,,,,,,,,Adhesion G protein-coupled receptor E3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000087,"[""LEU95 in BRSK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000087,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU95 in BRSK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100414,"[""Olfactory receptor 52D1""]",,"An olfactory receptor 52D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H346] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 52D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H346] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100414,,,,https://pharos.nih.gov/idg/targets/Q9H346,,,,,,,,,,,,,OR52D1,,,Q9H346,,,,,,,,Olfactory receptor 52D1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400144,"[""CSK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400144,,,,,,,,,,,,,,,,,,,,,,,,,,,,CSK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003777,"[""SCaBER cell""]",,Human urinary bladder squamous cell carcinoma cell line; established from a 58 years old black men.,false,,,http://purl.obolibrary.org/obo/BTO_0003776|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human urinary bladder squamous cell carcinoma cell line; established from a 58 years old black men.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003777,,,,,,,BrendaTissueOBO,,BTO:0003777,,,,,,,,,,,,,,,,,,,SCaBER cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200036,"[""AURKB gene""]",,"This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400130,,,,,,,,"This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200036,,,,,,,,,,,,,,,,9212,AURKB,AIK2|AIM1|AIRK2,,,,,,,,,,AURKB gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200333,"[""OR11H6 gene""]",,"An olfactory receptor 11H6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 11H6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200333,,,,,,,,,,,,,,,,122748,OR11H6,,,,,,,,,,,OR11H6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200428,"[""OR52L2P gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200428,,,,,,,,,,,,,,,,79274,OR52L2P,OR52L2,,,,,,,,,,OR52L2P gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100033,"[""Serine-protein kinase atm""]",,A serine-protein kinase ATM that is encoded in the genome of human. [PRO:CNA] ,false,,,http://www.drugtargetontology.org/dto/DTO_03300129,,,,,,,,A serine-protein kinase ATM that is encoded in the genome of human. [PRO:CNA] ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100033,,,,https://pharos.nih.gov/idg/targets/Q13315,,,,,,,,,,,,,ATM,,,Q13315,,,,,,,,Serine-protein kinase atm,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200608,"[""NME1-NME2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200608,,,,,,,,,,,,,,,,,,,,,,,,,,,,NME1-NME2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002503,"[""protozoan form""]",,Any individual of the Protozoa.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000284,,,,,,,,Any individual of the Protozoa.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002503,,,,,,,BrendaTissueOBO,protozoal form,BTO:0002503,,,,,,,,,,,,,,,,,,,protozoan form,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100389,"[""Serine/threonine-protein kinase pak 7""]",,"A serine/threonine-protein kinase PAK 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P286] |serine/threonine-protein kinase pak 7 (PAK7)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300304,,,,,,,,"A serine/threonine-protein kinase PAK 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P286] |serine/threonine-protein kinase pak 7 (PAK7)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100389,,,,https://pharos.nih.gov/idg/targets/Q9P286,,,,,,,,,,,,,PAK7,KIAA1264|PAK5,,Q9P286,,,,,,,,Serine/threonine-protein kinase pak 7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9834,"[""hyperopia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_9835,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9834,,,,SNOMEDCT_US_2016_03_01:155132008|ICD9CM:367.0|MESH:D006956|ICD10CM:H52.0|SNOMEDCT_US_2016_03_01:38101003|UMLS_CUI:C0020490,hypermetropia|Far-sightedness,,disease_ontology,,DOID:9834,,,,,,,,,,,,,,,,,,,hyperopia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000276,"[""MK12 kinase domain""]",,Mitogen-activated protein kinase 12; ERK3; ERK6; MAPK12; p38g; P38GAMMA; p38-gamma; PRKM12; SAPK3; SAPK-3,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase 12; ERK3; ERK6; MAPK12; p38g; P38GAMMA; p38-gamma; PRKM12; SAPK3; SAPK-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000276,,,,,,,,,,,,,,,,,,,200301,,,,,,,,,MK12 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200646,"[""OR5T2 gene""]",,"An olfactory receptor 5T2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5T2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200646,,,,,,,,,,,,,,,,219464,OR5T2,,,,,,,,,,,OR5T2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000578,"[""hepatoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000578,,,,,,,BrendaTissueOBO,hepatocarcinoma cell line|HCC cell line|hepatocellular carcinoma cell line,BTO:0000578,,,,,,,,,,,,,,,,,,,hepatoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060329,"[""ectopic pregnancy""]",,A female reproductive system disease characterized by the implantation of the embryo outside the uterine cavity.,false,,,http://purl.obolibrary.org/obo/DOID_229,,,,,,,,A female reproductive system disease characterized by the implantation of the embryo outside the uterine cavity.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060329,elvira,2015-02-25T19:27:50Z,,ICD10CM:O00.9|ICD10CM:O00|MESH:D011271|SNOMEDCT_US_2016_03_01:34801009|NCI:C34945|SNOMEDCT_US_2016_03_01:198630007|UMLS_CUI:C0032987|ICD9CM:633|SNOMEDCT_US_2016_03_01:156080003|ICD9CM:633.9|SNOMEDCT_US_2016_03_01:156083001,eccyesis,,disease_ontology,,DOID:0060329,,,,,,,,,,,,,,,,,,,ectopic pregnancy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060320,"[""inguinal hernia""]",,An intestinal disease characterized by a protrusion of abdominal cavity contests through the inguinal canal.,false,,,http://purl.obolibrary.org/obo/DOID_5295,,,,,,,,An intestinal disease characterized by a protrusion of abdominal cavity contests through the inguinal canal.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060320,emitraka,2015-02-25T15:54:50Z,,SNOMEDCT_US_2016_03_01:155741005|SNOMEDCT_US_2016_03_01:196828002|SNOMEDCT_US_2016_03_01:286969006|SNOMEDCT_US_2016_03_01:155738001|ICD10CM:K40.90|ICD9CM:550|UMLS_CUI:C0019294|SNOMEDCT_US_2016_03_01:196822001|ICD10CM:K40|SNOMEDCT_US_2016_03_01:266508004|MESH:D006552|SNOMEDCT_US_2016_03_01:73147001|SNOMEDCT_US_2016_03_01:65626001|SNOMEDCT_US_2016_03_01:261478001|HP:0000023|NCI:C34692|SNOMEDCT_US_2016_03_01:396232000|SNOMEDCT_US_2016_03_01:266509007|SNOMEDCT_US_2016_03_01:44297005|UMLS_CUI:C0019296|SNOMEDCT_US_2016_03_01:266440002|UMLS_CUI:C0019295|SNOMEDCT_US_2016_03_01:286968003|NCI:C34691|SNOMEDCT_US_2016_03_01:266510002|SNOMEDCT_US_2016_03_01:196827007|SNOMEDCT_US_2016_03_01:196800008|NCI:C34690|SNOMEDCT_US_2016_03_01:261480007|SNOMEDCT_US_2016_03_01:155744002,,,disease_ontology,,DOID:0060320,,,,,,,,,,,,,,,,,,,inguinal hernia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060327,"[""omphalocele""]",,"A physical disorder characterized by a defect in the development of the abdominal wall muscles, resulting in the intestines, liver and other organs to remain outside of the abdomen in a sac.",false,,,http://purl.obolibrary.org/obo/DOID_0080015,,,,,,,,"A physical disorder characterized by a defect in the development of the abdominal wall muscles, resulting in the intestines, liver and other organs to remain outside of the abdomen in a sac.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060327,emitraka,2015-02-25T17:54:05Z,,NCI:C98997|MESH:D006554|SNOMEDCT_US_2016_03_01:396347007|SNOMEDCT_US_2016_03_01:196872004|UMLS_CUI:C1306503|ICD10CM:Q79.2|SNOMEDCT_US_2016_03_01:196854005|SNOMEDCT_US_2016_03_01:271017007|SNOMEDCT_US_2016_03_01:5867007|ICD9CM:756.72|OMIM:164750|SNOMEDCT_US_2016_03_01:18735004|SNOMEDCT_US_2016_03_01:157007005|SNOMEDCT_US_2016_03_01:205516007|HP:0001539|UMLS_CUI:C0795690|SNOMEDCT_US_2016_03_01:49324006,omphalocoele,,disease_ontology,,DOID:0060327,,,,,,,,,,,,,,,,,,,omphalocele,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100418,"[""Olfactory receptor 52E5""]",,"An olfactory receptor 52E5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH55] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 52E5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH55] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100418,,,,https://pharos.nih.gov/idg/targets/Q8NH55,,,,,,,,,,,,,OR52E5,,,Q8NH55,,,,,,,,Olfactory receptor 52E5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000326,"[""PAK4 kinase domain""]",,P21 protein (Cdc42/Rac)-activated kinase 4; PAK4,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,P21 protein (Cdc42/Rac)-activated kinase 4; PAK4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000326,,,,,,,,,,,,,,,,,,,200305,,,,,,,,,PAK4 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002504,"[""T-lymphoblastic leukemia cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000739,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002504,,,,,,,BrendaTissueOBO,,BTO:0002504,,,,,,,,,,,,,,,,,,,T-lymphoblastic leukemia cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200729,"[""P2RY6 gene""]",,"A P2Y purinoceptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15077] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400100,,,,,,,,"A P2Y purinoceptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15077] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200729,,,,,,,,,,,,,,,,5031,P2RY6,,,,,,,,,,,P2RY6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100459,"[""Tyrosine-protein kinase transmembrane receptor ror1""]",,"A tyrosine-protein kinase transmembrane receptor ROR1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q01973] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300219,,,,,,,,"A tyrosine-protein kinase transmembrane receptor ROR1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q01973] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100459,,,,https://pharos.nih.gov/idg/targets/Q01973,,,,,,,,,,,,,ROR1,NTRKR1,,Q01973,,,,,,,,Tyrosine-protein kinase transmembrane receptor ror1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100245,"[""Protein kinase c eta type""]",,"protein kinase c eta type (KPCL)  with  no mutation  in a nonphosphorylated state|A protein kinase C eta type that is encoded in the genome of human. [PRO:WCB, UniProtKB:P24723] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300278,,,,,,,,"protein kinase c eta type (KPCL)  with  no mutation  in a nonphosphorylated state|A protein kinase C eta type that is encoded in the genome of human. [PRO:WCB, UniProtKB:P24723] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100245,,,,https://pharos.nih.gov/idg/targets/P24723,,,,,,,,,,,,,PRKCH,PKCL|PRKCL,,P24723,,,,,,,,Protein kinase c eta type,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200574,"[""OR4C13 gene""]",,"An olfactory receptor 4C13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4C13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200574,,,,,,,,,,,,,,,,283092,OR4C13,,,,,,,,,,,OR4C13 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200306,"[""MAST1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400160,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200306,,,,,,,,,,,,,,,,22983,MAST1,KIAA0973|SAST,,,,,,,,,,MAST1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80342,"[""Amylin""]",Islet amyloid polypeptide,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16130,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,Islet amyloid polypeptide,,,CHEBI:80342,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80342,,,,,Amylin,,CHEBI:80342,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100150,"[""ATP-sensitive inward rectifier potassium channel 11""]",,"An ATP-sensitive inward rectifier potassium channel 11 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14654] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300422,,,,,,,,"An ATP-sensitive inward rectifier potassium channel 11 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14654] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100150,,,,https://pharos.nih.gov/idg/targets/Q14654,,,,,,,,,,,,,KCNJ11,,,Q14654,,,,,,,,ATP-sensitive inward rectifier potassium channel 11,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000076,"[""LEU544 in TLK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000076,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU544 in TLK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100277,"[""Mitogen-activated protein kinase kinase kinase 11""]",,"A mitogen-activated protein kinase kinase kinase 11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16584] |mitogen-activated protein kinase kinase kinase 11 (MLK3)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300284,,,,,,,,"A mitogen-activated protein kinase kinase kinase 11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16584] |mitogen-activated protein kinase kinase kinase 11 (MLK3)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100277,,,,https://pharos.nih.gov/idg/targets/Q16584,,,,,,,,,,,,,MAP3K11,MLK3|PTK1|SPRK,,Q16584,,,,,,,,Mitogen-activated protein kinase kinase kinase 11,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100516,"[""Putative olfactory receptor 2B8""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100516,,,,https://pharos.nih.gov/idg/targets/P59922,,,,,,,,,,,,,OR2B8P,OR2B8,,P59922,,,,,,,,Putative olfactory receptor 2B8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_18420,"[""magnesium(2+)""]","Mg|magnesium, ion (Mg(2+))|Magnesium ions|Mg2+|InChI=1S/Mg/q+2|JLVVSXFLKOJNIY-UHFFFAOYSA-N|MAGNESIUM ION|magnesium, doubly charged positive ion|magnesium|Mg(2+)|[Mg++]",A magnesium cation that has formula Mg.,false,,,http://purl.obolibrary.org/obo/CHEBI_36916,,,,,,,CiteXplore:16419627|CiteXplore:14756024|CiteXplore:15584394|CiteXplore:15167956|CiteXplore:16732795|CiteXplore:15967566|CiteXplore:15059297|CiteXplore:15310301|CiteXplore:15999464|MetaCyc:13-HYDROXY-MAGNESIUM-PROTOPORP|CiteXplore:14770022|ChemIDplus:22537-22-0|CiteXplore:16548140|CiteXplore:15552844|CiteXplore:15585675|CiteXplore:15323205|CiteXplore:14979638|KEGG COMPOUND:C00305|CiteXplore:15243474|CiteXplore:24023812|HMDB:HMDB00547|CiteXplore:14734878|CiteXplore:22546835|PDBeChem:MG|Wikipedia:Magnesium|CiteXplore:15262910|CiteXplore:15116072|CiteXplore:16052852|Gmelin:6857|CiteXplore:16244393|NIST Chemistry WebBook:22537-22-0,A magnesium cation that has formula Mg.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:6635|CHEBI:25112|CHEBI:13379|CHEBI:49736,,magnesium(2+) ion|magnesium(2+)|magnesium(II) cation|magnesium cation,,chebi_ontology,"Mg|magnesium, ion (Mg(2+))|Magnesium ions|Mg2+|InChI=1S/Mg/q+2|JLVVSXFLKOJNIY-UHFFFAOYSA-N|MAGNESIUM ION|magnesium, doubly charged positive ion|magnesium|Mg(2+)|[Mg++]",,,CHEBI:18420,,,,,,,,,,,,,,,,,,,,,,,CHEBI:18420,,,,,magnesium(2+),,CHEBI:18420,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100235,"[""Leucine-rich repeat-containing g-protein coupled receptor 4""]",,"A leucine-rich repeat-containing G-protein coupled receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BXB1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A leucine-rich repeat-containing G-protein coupled receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BXB1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100235,,,,https://pharos.nih.gov/idg/targets/Q9BXB1,,,,,,,,,,,,,LGR4,GPR48,,Q9BXB1,,,,,,,,Leucine-rich repeat-containing g-protein coupled receptor 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100474,"[""Medium-wave-sensitive opsin 1""]",,A medium-wave-sensitive opsin 1 that is encoded in the genome of human. [PRO:WCB] ,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,A medium-wave-sensitive opsin 1 that is encoded in the genome of human. [PRO:WCB] ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100474,,,,https://pharos.nih.gov/idg/targets/P04001,,,,,,,,,,,,,OPN1MW,GCP|OPN1MW2,,P04001,,,,,,,,Medium-wave-sensitive opsin 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100299,"[""Sodium channel protein type 8 subunit alpha""]",,"A sodium channel protein type 8 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UQD0] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300473,,,,,,,,"A sodium channel protein type 8 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UQD0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100299,,,,https://pharos.nih.gov/idg/targets/Q9UQD0,,,,,,,,,,,,,SCN8A,MED,,Q9UQD0,,,,,,,,Sodium channel protein type 8 subunit alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000039,"[""L-lactic acid""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_33575,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000039,,,,,,,,,,,,,,,,,,,,,,,,,,,,L-lactic acid,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400025,"[""Bradykinin receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400025,,,,,,,,,,,,,,,,,,,,,,,,,,,,Bradykinin receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3978,"[""extrinsic cardiomyopathy""]",,A cardiomyopathy that is characterized by the pathology occuring outside of the myocardium.,false,,,http://purl.obolibrary.org/obo/DOID_0050700,,,,,,,,A cardiomyopathy that is characterized by the pathology occuring outside of the myocardium.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3978,,,,ICD9CM:425.8|SNOMEDCT_US_2016_03_01:195580005|UMLS_CUI:C0155699,,,disease_ontology,,DOID:3978,,,,,,,,,,,,,,,,,,,extrinsic cardiomyopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2256,"[""osteochondrodysplasia""]",,A bone development disease that results_in defective development of cartilage or bone.,false,,,http://purl.obolibrary.org/obo/DOID_0080006,,,,,,,,A bone development disease that results_in defective development of cartilage or bone.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2256,,,DOID:1764,OMIM:215050|SNOMEDCT_US_2016_03_01:205510001|SNOMEDCT_US_2016_03_01:205539001|UMLS_CUI:C0008449|UMLS_CUI:C0029422|SNOMEDCT_US_2016_03_01:105985007|NCI:C34466|SNOMEDCT_US_2016_03_01:378007|SNOMEDCT_US_2016_03_01:67988000|NCI:C84978|ICD9CM:756.4|SNOMEDCT_US_2016_03_01:268350005|MESH:D010009|SNOMEDCT_US_2016_03_01:240190009|ICD10CM:Q78.9,Congenital anomaly of cartilage (disorder)|chondrodystrophy|Osteochondrodysplasia syndrome (disorder)|Cartilage Development disorder,,disease_ontology,,DOID:2256,,,,,,,,,,,,,,,,,,,osteochondrodysplasia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100195,"[""Inositol-tetrakisphosphate 1-kinase""]",,"An inositol-tetrakisphosphate 1-kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13572] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391020,,,,,,,,"An inositol-tetrakisphosphate 1-kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13572] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100195,,,,https://pharos.nih.gov/idg/targets/Q13572,,,,,,,,,,,,,ITPK1,,,Q13572,,,,,,,,Inositol-tetrakisphosphate 1-kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000209,"[""CXCL10""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000209,,,,,,,,,,,,,,,,,,,,,,,,,,,,CXCL10,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200037,"[""CACNA2D4 gene""]",,"This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400332,,,,,,,,"This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200037,,,,,,,,,,,,,,,,93589,CACNA2D4,,,,,,,,,,,CACNA2D4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100433,"[""Serine/threonine-protein kinase plk4""]",,"serine/threonine-protein kinase plk4 (PLK4)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase PLK4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00444] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300211,,,,,,,,"serine/threonine-protein kinase plk4 (PLK4)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase PLK4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00444] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100433,,,,https://pharos.nih.gov/idg/targets/O00444,,,,,,,,,,,,,PLK4,SAK|STK18,,O00444,,,,,,,,Serine/threonine-protein kinase plk4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100088,"[""Adhesion G protein-coupled receptor L4""]",,"An EGF, latrophilin and seven transmembrane domain-containing protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HBW9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300039,,,,,,,,"An EGF, latrophilin and seven transmembrane domain-containing protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HBW9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100088,,,,https://pharos.nih.gov/idg/targets/Q9HBW9,,,,,,,,,,,,,ELTD1,ADGRL4|ETL,,Q9HBW9,,,,,,,,Adhesion G protein-coupled receptor L4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00500648,"[""Mechanically-gated""]",,"""Mechanically-gated"" is used in context to certain ion channel proteins. Mechanically-gated ion channels are the channels that open in response to mechanical movement of adjacent structures.",false,,,http://www.drugtargetontology.org/dto/DTO_00500669,,,,,,,,"""Mechanically-gated"" is used in context to certain ion channel proteins. Mechanically-gated ion channels are the channels that open in response to mechanical movement of adjacent structures.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00500648,,,,,,,,,,,,,,,,,,,,,,,,,,,https://courses.washington.edu/conj/membrane/transport.htm,Mechanically-gated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000331,"[""THR315 in ABL1(H396P)-nonphosphorylated""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000331,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR315 in ABL1(H396P)-nonphosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000057,"[""LEU152 in RSK4(Kin.Dom.1-N-terminal)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000057,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU152 in RSK4(Kin.Dom.1-N-terminal),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300367,"[""Polycystin cation channel (pcc) family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300367,,,,,,,,,,,,,,,,,,,,,,,,,,,,Polycystin cation channel (pcc) family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300266,"[""Dyrk1 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300150,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300266,,,,,,,,,,,,,,,,,,,,,,,,,,,,Dyrk1 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11227,"[""acute hemorrhagic conjunctivitis""]",,"A viral infectious disease that results_in inflammation located in conjunctiva, has_material_basis_in Human coxsackievirus A24 or has_material_basis_in Human enterovirus 70, which are transmitted_by contaminated fomites or transmitted_by contact with contaminated hands. The infection has_symptom vascular dilation, has_symptom eyelid edema, has_symptom photophobia, has_symptom redness of the eyes, has_symptom watering of the eye, has_symptom conjunctival congestion, and has_symptom superficial punctate epithelial keratitis.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in inflammation located in conjunctiva, has_material_basis_in Human coxsackievirus A24 or has_material_basis_in Human enterovirus 70, which are transmitted_by contaminated fomites or transmitted_by contact with contaminated hands. The infection has_symptom vascular dilation, has_symptom eyelid edema, has_symptom photophobia, has_symptom redness of the eyes, has_symptom watering of the eye, has_symptom conjunctival congestion, and has_symptom superficial punctate epithelial keratitis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11227,,,,NCI:C34505|SNOMEDCT_US_2016_03_01:186677009|ICD9CM:077.4|SNOMEDCT_US_2016_03_01:398264003|UMLS_CUI:C0009765|SNOMEDCT_US_2016_03_01:31502007|SNOMEDCT_US_2016_03_01:398273006|MESH:D003232,Apollo disease|Epidemic hemorrhagic conjunctivitis,,disease_ontology,viral conjunctivitis,DOID:11227,,,,,,,,,,,,,,,,,,,acute hemorrhagic conjunctivitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200164,"[""GPR173 gene""]",,"A G-protein coupled receptor 173 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NS66] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 173 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NS66] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200164,,,,,,,,,,,,,,,,54328,GPR173,SREB3,,,,,,,,,,GPR173 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200656,"[""OR6C3 gene""]",,"An olfactory receptor 6C3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZP0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6C3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZP0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200656,,,,,,,,,,,,,,,,254786,OR6C3,,,,,,,,,,,OR6C3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100162,"[""G protein-activated inward rectifier potassium channel 2""]",,"A G protein-activated inward rectifier potassium channel 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48051] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300433,,,,,,,,"A G protein-activated inward rectifier potassium channel 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48051] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100162,,,,https://pharos.nih.gov/idg/targets/P48051,,,,,,,,,,,,,KCNJ6,GIRK2|KATP2|KCNJ7,,P48051,,,,,,,,G protein-activated inward rectifier potassium channel 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11320,"[""Kyasanur forest disease""]",,"A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Kyasanur forest disease virus, which is transmitted_by Haemaphysalis spinigera tick bite. The infection has_symptom fever, has_symptom headache, has_symptom stiffness of the neck, has_symptom severe muscle pain, has_symptom cough, has_symptom dehydration, and has_symptom bleeding problems.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Kyasanur forest disease virus, which is transmitted_by Haemaphysalis spinigera tick bite. The infection has_symptom fever, has_symptom headache, has_symptom stiffness of the neck, has_symptom severe muscle pain, has_symptom cough, has_symptom dehydration, and has_symptom bleeding problems.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11320,,,,UMLS_CUI:C0022810|MESH:D007733|SNOMEDCT_US_2016_03_01:23097003|ICD9CM:065.2|ICD10CM:A98.2,,,disease_ontology,,DOID:11320,http://purl.obolibrary.org/obo/doid#tick-borne_infectious_disease,,,,,,,,,,,,,,,,,,Kyasanur forest disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11328,"[""schizophreniform disorder""]",,A psychotic disorder that involves schizophrenia symptoms over time period of one month.,false,,,http://purl.obolibrary.org/obo/DOID_2468,,,,,,,,A psychotic disorder that involves schizophrenia symptoms over time period of one month.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11328,,,,UMLS_CUI:C0036358|SNOMEDCT_US_2016_03_01:88975006|ICD10CM:F20.81|NCI:C94376|ICD9CM:295.4|MESH:D011618,,,disease_ontology,,DOID:11328,,,,,,,,,,,,,,,,,,,schizophreniform disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200079,"[""CLIC1 gene""]",,"Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1  is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400342,,,,,,,,"Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1  is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200079,,,,,,,,,,,,,,,,1192,CLIC1,G6|NCC27,,,,,,,,,,CLIC1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200294,"[""MAP4K2 gene""]",," The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400287,,,,,,,," The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200294,,,,,,,,,,,,,,,,5871,MAP4K2,GCK|RAB8IP,,,,,,,,,,MAP4K2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100709,"[""Olfactory receptor 8u8""]",,"An olfactory receptor 8U8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7N1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 8U8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7N1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100709,,,,https://pharos.nih.gov/idg/targets/P0C7N1,,,,,,,,,,,,,OR8U8,,,P0C7N1,,,,,,,,Olfactory receptor 8u8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1115,"[""sarcoma""]",,A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from embryonic mesoderm.,false,,,http://purl.obolibrary.org/obo/DOID_0050687,,,,,,,,A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from embryonic mesoderm.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1115,,,DOID:3936,ICD10CM:C49|SNOMEDCT_US_2016_03_01:187985009|UMLS_CUI:C0153519|SNOMEDCT_US_2016_03_01:93765001|ICD9CM:171.9|ICD9CM:171,connective and soft tissue neoplasm|tumor of soft tissue and skeleton,,disease_ontology,,DOID:1115,http://purl.obolibrary.org/obo/doid#DO_cancer_slim|http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,sarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11151,"[""cholecystolithiasis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060262,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11151,,,,SNOMEDCT_US_2016_03_01:266541001|MESH:D041761|UMLS_CUI:C0947622|NCI:C34443|SNOMEDCT_US_2016_03_01:44900007|SNOMEDCT_US_2016_03_01:197376000|SNOMEDCT_US_2016_03_01:235919008,,,disease_ontology,,DOID:11151,,,,,,,,,,,,,,,,,,,cholecystolithiasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11155,"[""hypohidrosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1383,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11155,,,,MESH:D007007|SNOMEDCT_US_2016_03_01:45004005|ICD10CM:L74.4|UMLS_CUI:C0020620|SNOMEDCT_US_2016_03_01:201189007|NCI:C34718,Hypohidrosis (disorder)|Oligohidrosis,,disease_ontology,,DOID:11155,,,,,,,,,,,,,,,,,,,hypohidrosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11156,"[""anhidrosis""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_1383,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11156,,,,MESH:D007007|SNOMEDCT_US_2016_03_01:39659002|SNOMEDCT_US_2016_03_01:156414006|SNOMEDCT_US_2016_03_01:14662005|ICD10CM:L74.4|UMLS_CUI:C0003028|OMIM:206600|ICD9CM:705.0|NCI:C34385|SNOMEDCT_US_2016_03_01:201189007,absence of sweating|Adiaphoresis,,disease_ontology,,DOID:11156,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,anhidrosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11153,"[""miliaria rubra""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1382,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11153,,,,MESH:D008883|SNOMEDCT_US_2016_03_01:72658003|ICD9CM:705.1|SNOMEDCT_US_2016_03_01:44279002|ICD10CM:L74.0|SNOMEDCT_US_2016_03_01:267813002|SNOMEDCT_US_2016_03_01:201194007|UMLS_CUI:C0162423|SNOMEDCT_US_2016_03_01:201197000|SNOMEDCT_US_2016_03_01:156415007|ICD10CM:L74.2|SNOMEDCT_US_2016_03_01:201190003,Sudamina|Miliaria crystallina|Prickly heat - miliaria,,disease_ontology,,DOID:11153,,,,,,,,,,,,,,,,,,,miliaria rubra,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000175,"[""MET458 in KPCT""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000175,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET458 in KPCT,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200253,"[""RPS6KA3 gene""]",,"This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400280,,,,,,,,"This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200253,,,,,,,,,,,,,,,,6197,RPS6KA3,ISPK1|MAPKAPK1B|RSK2,,,,,,,,,,RPS6KA3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100028,"[""K545 in PIK3CA(E545K)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100028,,,,,,,,,,,,,,,,,,,,,,,,,,,,K545 in PIK3CA(E545K),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100676,"[""Olfactory receptor 7A10""]",,"An olfactory receptor 7A10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76100] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 7A10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76100] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100676,,,,https://pharos.nih.gov/idg/targets/O76100,,,,,,,,,,,,,OR7A10,,,O76100,,,,,,,,Olfactory receptor 7A10,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200004,"[""HTR3D gene""]",,"The protein encoded this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit D of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a mitogen and a hormone. This hormone has been linked to neuropsychiatric disorders, including anxiety, depression, and migraine. Serotonin receptors causes fast and depolarizing responses in neurons following activation. The genes encoding subunits C, D and E of this type 3 receptor form a cluster on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01409932,,,,,,,,"The protein encoded this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit D of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a mitogen and a hormone. This hormone has been linked to neuropsychiatric disorders, including anxiety, depression, and migraine. Serotonin receptors causes fast and depolarizing responses in neurons following activation. The genes encoding subunits C, D and E of this type 3 receptor form a cluster on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200004,,,,,,,,,,,,,,,,200909,HTR3D,,,,,,,,,,,HTR3D gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3122,"[""gastric outlet obstruction""]",,,false,,,http://purl.obolibrary.org/obo/DOID_76,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3122,,,,UMLS_CUI:C0162651|MESH:D017219|SNOMEDCT_US_2016_03_01:244815007|SNOMEDCT_US_2016_03_01:196759006,gastric outflow obstruction,,disease_ontology,,DOID:3122,,,,,,,,,,,,,,,,,,,gastric outlet obstruction,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3082,"[""interstitial lung disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_850,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3082,,,,ICD10CM:J84.9|MESH:D017563|SNOMEDCT_US_2016_03_01:233703007|SNOMEDCT_US_2016_03_01:64667001|UMLS_CUI:C0206062,ILD,,disease_ontology,,DOID:3082,,,,,,,,,,,,,,,,,,,interstitial lung disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001049,"[""pharynx""]",,The part of the vertebrate alimentary canal between the cavity of the mouth and the esophagus. The pharynx of Nematodes is an efficient pump and forces food into the intestines.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The part of the vertebrate alimentary canal between the cavity of the mouth and the esophagus. The pharynx of Nematodes is an efficient pump and forces food into the intestines.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001049,,,,,,,BrendaTissueOBO,,BTO:0001049,,,,,,,,,,,,,,,,,,,pharynx,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000291,"[""MP2K6 kinase domain""]",,Dual specificity mitogen-activated protein kinase kinase 6; mitogen-activated protein kinase kinase 6; MAP2K6; MAPKK6; MEK6; MKK6; MKK6/MAP2K6; PRKMK6; SAPKK3,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Dual specificity mitogen-activated protein kinase kinase 6; mitogen-activated protein kinase kinase 6; MAP2K6; MAPKK6; MEK6; MKK6; MKK6/MAP2K6; PRKMK6; SAPKK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000291,,,,,,,,,,,,,,,,,,,200256,,,,,,,,,MP2K6 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400573,"[""Kv8.2/KCNV2 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400451,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400573,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv8.2/KCNV2 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004190,"[""pacemaker cell""]",,A group of cells or a body part (as the sinus node of the heart) that serves to establish and maintain a rhythmic activity.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A group of cells or a body part (as the sinus node of the heart) that serves to establish and maintain a rhythmic activity.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004190,,,,,,,BrendaTissueOBO,Reizbildungszentrum,BTO:0004190,,,,,,,,,,,,,,,,,,,pacemaker cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100652,"[""Olfactory receptor 6b2""]",,"An olfactory receptor 6B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IFH4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IFH4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100652,,,,https://pharos.nih.gov/idg/targets/Q6IFH4,,,,,,,,,,,,,OR6B2,OR6B2P,,Q6IFH4,,,,,,,,Olfactory receptor 6b2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100471,"[""Nociceptin receptor""]",,"A nociceptin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41146] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A nociceptin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41146] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100471,,,,https://pharos.nih.gov/idg/targets/P41146,,,,,,,,,,,,,OPRL1,OOR|ORL1,,P41146,,,,,,,,Nociceptin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2101,"[""vulva squamous cell carcinoma""]",,A vulva carcinoma and has_material_basis_in squamous cells and is located_in the epidermis of the vulvar tissue.,false,,,http://purl.obolibrary.org/obo/DOID_1749|http://purl.obolibrary.org/obo/DOID_1294,,,,,,,,A vulva carcinoma and has_material_basis_in squamous cells and is located_in the epidermis of the vulvar tissue.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2101,,,,NCI:C4052|UMLS_CUI:C0280856|SNOMEDCT_US_2016_03_01:254895003,Vulvar Epidermoid carcinoma|vulvar squamous cell carcinoma,,disease_ontology,squamous cell carcinoma of vulva,DOID:2101,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,vulva squamous cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100177,"[""Hexokinase-1""]",,"A hexokinase-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P19367] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391017,,,,,,,,"A hexokinase-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P19367] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100177,,,,https://pharos.nih.gov/idg/targets/P19367,,,,,,,,,,,,,HK1,,,P19367,,,,,,,,Hexokinase-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_29999,"[""L-serine residue""]",,A serine residue that has L configuration.,false,,,http://purl.obolibrary.org/obo/CHEBI_33700,,,,,,,,A serine residue that has L configuration.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:29999,,,,RESID:AA0016,L-serine residue,,chebi_ontology,87.07734|L-seryl|87.032|S|Ser|C3H5NO2|-Ser-|0|L-serine,CHEBI:29999,http://purl.obolibrary.org/obo/chebi#3_STAR,,,,,,,,,,,,,,,,,,L-serine residue,,,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002075,"[""mesenchymal epithelium""]",,"The epithelium which lines the subdural and subarachnoid spaces, the perilymphatic spaces in the inner ear, and the chamber of the eye.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000416,,,,,,,,"The epithelium which lines the subdural and subarachnoid spaces, the perilymphatic spaces in the inner ear, and the chamber of the eye.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002075,,,,,,,BrendaTissueOBO,,BTO:0002075,,,,,,,,,,,,,,,,,,,mesenchymal epithelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000930,"[""neuroblast""]",,Any embryonic cell which develops into a nerve cell or neuron; an immature nerve cell.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Any embryonic cell which develops into a nerve cell or neuron; an immature nerve cell.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000930,,,,,,,BrendaTissueOBO,,BTO:0000930,,,,,,,,,,,,,,,,,,,neuroblast,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100439,"[""Putative serine/threonine-protein kinase prky""]",,"A serine/threonine-protein kinase PRKY that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43930] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300169,,,,,,,,"A serine/threonine-protein kinase PRKY that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43930] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100439,,,,https://pharos.nih.gov/idg/targets/O43930,,,,,,,,,,,,,PRKY,,,O43930,,,,,,,,Putative serine/threonine-protein kinase prky,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001439,"[""venom""]",,"Poisonous matter normally secreted by some animals (as snakes, scorpions, or bees) and transmitted to prey or an enemy chiefly by biting or stinging; broadly: material that is poisonous.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Poisonous matter normally secreted by some animals (as snakes, scorpions, or bees) and transmitted to prey or an enemy chiefly by biting or stinging; broadly: material that is poisonous.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001439,,,,,,,BrendaTissueOBO,,BTO:0001439,,,,,,,,,,,,,,,,,,,venom,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200410,"[""PIP4K2B gene""]",,"The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400323,,,,,,,,"The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200410,,,,,,,,,,,,,,,,8396,PIP4K2B,PIP5K2B,,,,,,,,,,PIP4K2B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100787,"[""Taste receptor type 2 member 41""]",,"A taste receptor type 2 member 41 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59536] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300014,,,,,,,,"A taste receptor type 2 member 41 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59536] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100787,,,,https://pharos.nih.gov/idg/targets/P59536,,,,,,,,,,,,,TAS2R41,,,P59536,,,,,,,,Taste receptor type 2 member 41,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000590,"[""Alzheimer disease specific cell type""]",,"Alzheimer is a disease marked by the loss of cognitive ability, generally over a period of 10 to 15 years, and associated with the development of abnormal tissues and protein deposits in the cerebral cortex.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Alzheimer is a disease marked by the loss of cognitive ability, generally over a period of 10 to 15 years, and associated with the development of abnormal tissues and protein deposits in the cerebral cortex.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000590,,,,,,,BrendaTissueOBO,Alzheimer specific cell type,BTO:0000590,,,,,,,,,,,,,,,,,,,Alzheimer disease specific cell type,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000223,"[""teratocarcinoma cell""]",,A malignant tumor cell of the testis composed of teratoma and embryonal carcinoma.,false,,,http://purl.obolibrary.org/obo/BTO_0000279|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A malignant tumor cell of the testis composed of teratoma and embryonal carcinoma.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000223,,,,,,,BrendaTissueOBO,,BTO:0000223,,,,,,,,,,,,,,,,,,,teratocarcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400059,"[""Metabotropic glutamate receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400004,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400059,,,,,,,,,,,,,,,,,,,,,,,,,,,,Metabotropic glutamate receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300301,"[""NuaK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300116,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300301,,,,,,,,,,,,,,,,,,,,,,,,,,,,NuaK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3587,"[""pancreatic ductal carcinoma""]",,A pancreatic carcinoma located_in the pancreatic duct.,false,,,http://purl.obolibrary.org/obo/DOID_4905,,,,,,,,A pancreatic carcinoma located_in the pancreatic duct.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3587,,,DOID:10023,UMLS_CUI:C0887833|SNOMEDCT_US_2016_03_01:187793004|ICD10CM:C25.3|ICD9CM:157.3|UMLS_CUI:C0153461|MESH:D021441|SNOMEDCT_US_2016_03_01:93939009,malignant neoplasm of duct of Wirsung|pancreatic duct cancer,,disease_ontology,,DOID:3587,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,pancreatic ductal carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200281,"[""NPY1R gene""]",,"A neuropeptide Y receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25929] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400071,,,,,,,,"A neuropeptide Y receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25929] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200281,,,,,,,,,,,,,,,,4886,NPY1R,NPYR|NPYY1,,,,,,,,,,NPY1R gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000276,"[""PHE691 in FLT3-autoinhibited""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000276,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE691 in FLT3-autoinhibited,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100824,"[""Vomeronasal type-1 receptor 5""]",,"A vomeronasal type-1 receptor 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z5H4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300016,,,,,,,,"A vomeronasal type-1 receptor 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z5H4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100824,,,,https://pharos.nih.gov/idg/targets/Q7Z5H4,,,,,,,,,,,,,VN1R5,V1RL5,,Q7Z5H4,,,,,,,,Vomeronasal type-1 receptor 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100629,"[""ADP-dependent glucokinase""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100629,,,,,,,,,,,,,,,,,ADPGK,,,Q9BRR6,,,,,,,,ADP-dependent glucokinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200522,"[""OR2F1 gene""]",,"An olfactory receptor 2F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13607] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13607] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200522,,,,,,,,,,,,,,,,26211,OR2F1,OLF3|OR2F3|OR2F3P|OR2F4|OR2F5,,,,,,,,,,OR2F1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300530,"[""Kv1.8/KCNA10 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300436,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300530,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv1.8/KCNA10 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003219,"[""TMK-1 cell""]",,Human gastric cancer cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000787,,,,,,,,Human gastric cancer cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003219,,,,,,,BrendaTissueOBO,TMK1 cell,BTO:0003219,,,,,,,,,,,,,,,,,,,TMK-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200350,"[""OR13J1 gene""]",,"An olfactory receptor 13J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 13J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200350,,,,,,,,,,,,,,,,392309,OR13J1,,,,,,,,,,,OR13J1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100606,"[""Olfactory receptor 4Q3""]",,"An olfactory receptor 4Q3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH05] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4Q3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH05] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100606,,,,https://pharos.nih.gov/idg/targets/Q8NH05,,,,,,,,,,,,,OR4Q3,C14orf13|OR4Q4,,Q8NH05,,,,,,,,Olfactory receptor 4Q3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100043,"[""Bone morphogenetic protein receptor type-2""]",,"A BMP receptor type-2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13873] |bone morphogenetic protein receptor type-2 (BMPR2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300252,,,,,,,,"A BMP receptor type-2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13873] |bone morphogenetic protein receptor type-2 (BMPR2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100043,,,,https://pharos.nih.gov/idg/targets/Q13873,,,,,,,,,,,,,BMPR2,PPH1,,Q13873,,,,,,,,Bone morphogenetic protein receptor type-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200149,"[""KCNJ10 gene""]",,"This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400421,,,,,,,,"This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200149,,,,,,,,,,,,,,,,3766,KCNJ10,,,,,,,,,,,KCNJ10 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200666,"[""OR6N2 gene""]",,"An olfactory receptor 6N2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6N2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200666,,,,,,,,,,,,,,,,81442,OR6N2,,,,,,,,,,,OR6N2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200037,"[""AURKC gene""]",,"This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400130,,,,,,,,"This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200037,,,,,,,,,,,,,,,,6795,AURKC,AIE2|AIK3|AIRK3|ARK3,,,,,,,,,,AURKC gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100613,"[""Olfactory receptor 5B2""]",,"An olfactory receptor 5B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R09] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R09] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100613,,,,https://pharos.nih.gov/idg/targets/Q96R09,,,,,,,,,,,,,OR5B2,,,Q96R09,,,,,,,,Olfactory receptor 5B2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8805,"[""intermediate coronary syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3393,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8805,,,,ICD10CM:I20.0|SNOMEDCT_US_2016_03_01:4557003|SNOMEDCT_US_2016_03_01:64333001|SNOMEDCT_US_2016_03_01:194816008|SNOMEDCT_US_2016_03_01:155314002|SNOMEDCT_US_2016_03_01:155308009|SNOMEDCT_US_2016_03_01:233818002|ICD9CM:411.1|SNOMEDCT_US_2016_03_01:59021001|SNOMEDCT_US_2016_03_01:233820004|SNOMEDCT_US_2016_03_01:194819001|SNOMEDCT_US_2016_03_01:194814006|SNOMEDCT_US_2016_03_01:194817004|SNOMEDCT_US_2016_03_01:25106000|SNOMEDCT_US_2016_03_01:155313008|NCI:C66911|MESH:D000789|UMLS_CUI:C0002965,Worsening angina|Preinfarction angina|Unstable angina|Preinfarction angina (disorder)|Angina at rest|(Angina: [crescendo] or [unstable] or [at rest]) or (preinfarction syndrome) or (impending infarction)|Impending infarction (disorder)|Anginal chest pain at rest,,disease_ontology,,DOID:8805,,,,,,,,,,,,,,,,,,,intermediate coronary syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003709,"[""RWPE-1 cell""]",,Epithelial cells derived from the peripheral zone of a histologically normal adult human prostate were transfected with a single copy of the human papilloma virus 18 to establish the cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002398,,,,,,,,Epithelial cells derived from the peripheral zone of a histologically normal adult human prostate were transfected with a single copy of the human papilloma virus 18 to establish the cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003709,,,,,,,BrendaTissueOBO,RWPE1 cell,BTO:0003709,,,,,,,,,,,,,,,,,,,RWPE-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200463,"[""OR7E24 gene""]",,"An olfactory receptor 7E24 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IFN5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 7E24 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IFN5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200463,,,,,,,,,,,,,,,,26648,OR7E24,OR7E24P,,,,,,,,,,OR7E24 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1686,"[""glaucoma""]",,An eye disease that is characterized by an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function.,false,,,http://purl.obolibrary.org/obo/DOID_5614,,,,,,,,An eye disease that is characterized by an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1686,,,,ICD10CM:H40-H42|SNOMEDCT_US_2016_03_01:194631001|MESH:D005901|ICD9CM:365|NCI:C26782|SNOMEDCT_US_2016_03_01:155120009|ICD9CM:365.9|UMLS_CUI:C0017601|SNOMEDCT_US_2016_03_01:193569008|SNOMEDCT_US_2016_03_01:23986001|ICD10CM:H40.9|ICD10CM:H40|EFO:0000516,,,disease_ontology,,DOID:1686,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,glaucoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100390,"[""Pab-dependent poly(a)-specific ribonuclease subunit pan3""]",,"A PAB-dependent poly(A)-specific ribonuclease subunit 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q58A45] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300201,,,,,,,,"A PAB-dependent poly(A)-specific ribonuclease subunit 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q58A45] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100390,,,,https://pharos.nih.gov/idg/targets/Q58A45,,,,,,,,,,,,,PAN3,,,Q58A45,,,,,,,,Pab-dependent poly(a)-specific ribonuclease subunit pan3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000395,"[""RSK1(Kin.Dom.2-C-terminal) kinase domain""]",,"Ribosomal protein S6 kinase, 90kDa, polypeptide 1; HU-1; MAPKAPK1A; RPS6KA1; RSK; RSK1; RSK3",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Ribosomal protein S6 kinase, 90kDa, polypeptide 1; HU-1; MAPKAPK1A; RPS6KA1; RSK; RSK1; RSK3",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000395,,,,,,,,,,,,,,,,,,,"200385, 200400",,,,,,,,,RSK1(Kin.Dom.2-C-terminal) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000259,"[""MAPKAPK2 kinase domain""]",,Mitogen-activated protein kinase-activated protein kinase 2; MAPKAPK2; MK2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase-activated protein kinase 2; MAPKAPK2; MK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000259,,,,,,,,,,,,,,,,,,,200244,,,,,,,,,MAPKAPK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400239,"[""TTBK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400112,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400239,,,,,,,,,,,,,,,,,,,,,,,,,,,,TTBK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200447,"[""OR5AK2 gene""]",,"An olfactory receptor 5AK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH90] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5AK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH90] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200447,,,,,,,,,,,,,,,,390181,OR5AK2,,,,,,,,,,,OR5AK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400022,"[""Adrenoceptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400022,,,,,,,,,,,,,,,,,,,,,,,,,,,,Adrenoceptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000304,"[""THR106 in MK14""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000304,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR106 in MK14,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100254,"[""Melanocortin receptor 5""]",,"A melanocortin receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P33032] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300021,,,,,,,,"A melanocortin receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P33032] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100254,,,,https://pharos.nih.gov/idg/targets/P33032,,,,,,,,,,,,,MC5R,,,P33032,,,,,,,,Melanocortin receptor 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001374,"[""thymus""]",,"A glandular structure of largely lymphoid tissue that functions especially in the development of the body's immune system, is present in the young of most vertebrates typically in the upper anterior chest or at the base of the neck, and tends to atrophy in the adult.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001488|http://purl.obolibrary.org/obo/BTO_0000753,,,,,,,,"A glandular structure of largely lymphoid tissue that functions especially in the development of the body's immune system, is present in the young of most vertebrates typically in the upper anterior chest or at the base of the neck, and tends to atrophy in the adult.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001374,,,,,,,BrendaTissueOBO,,BTO:0001374,,,,,,,,,,,,,,,,,,,thymus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9274,"[""hyperlysinemia""]",,An amino acid metabolic disorder that involves an abnormal increase of lysine in the blood.,false,,,http://purl.obolibrary.org/obo/DOID_9252,,,,,,,,An amino acid metabolic disorder that involves an abnormal increase of lysine in the blood.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9274,,,,NCI:C123433|ORDO:2203|MESH:D020167|OMIM:238700|UMLS_CUI:C0268553|SNOMEDCT_US_2016_03_01:58558003|OMIM:238710|ICD10CM:E72.3,,,disease_ontology,,DOID:9274,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,hyperlysinemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000391,"[""RPS6KA4(Kin.Dom.2-C-terminal) kinase domain""]",,"Ribosomal protein S6 kinase, 90kDa, polypeptide 4; MSK2; MSK2~b; RPS6KA4; RSK-B",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Ribosomal protein S6 kinase, 90kDa, polypeptide 4; MSK2; MSK2~b; RPS6KA4; RSK-B",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000391,,,,,,,,,,,,,,,,,,,"200391, 200392",,,,,,,,,RPS6KA4(Kin.Dom.2-C-terminal) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100025,"[""Muscarinic acetylcholine receptor M5""]",,"A muscarinic acetylcholine receptor M5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08912] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300020,,,,,,,,"A muscarinic acetylcholine receptor M5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08912] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100025,,,,https://pharos.nih.gov/idg/targets/P08912,,,,,,,,,,,,,CHRM5,,,P08912,,,,,,,,Muscarinic acetylcholine receptor M5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100342,"[""Serine/threonine-protein kinase mrck beta""]",,"A serine/threonine-protein kinase MRCK beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y5S2] |serine/threonine-protein kinase mrck beta (MRCKB)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300265,,,,,,,,"A serine/threonine-protein kinase MRCK beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y5S2] |serine/threonine-protein kinase mrck beta (MRCKB)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100342,,,,https://pharos.nih.gov/idg/targets/Q9Y5S2,,,,,,,,,,,,,CDC42BPB,KIAA1124,,Q9Y5S2,,,,,,,,Serine/threonine-protein kinase mrck beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_7608,"[""parathyroid adenoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060089|http://purl.obolibrary.org/obo/DOID_11201|http://purl.obolibrary.org/obo/DOID_657,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:7608,,,,SNOMEDCT_US_2016_03_01:128474007|UMLS_CUI:C0262587|NCI:C3916|MESH:D010282,adenoma of the Parathyroid gland,,disease_ontology,adenoma of parathyroid,DOID:7608,,,,,,,,,,,,,,,,,,,parathyroid adenoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9870,"[""galactosemia""]",,A carbohydrate metabolic disorder that involves a defect in galactose metabolism resulting in toxic levels of galactose 1-phosphate in various tissues.,false,,,http://purl.obolibrary.org/obo/DOID_2978,,,,,,,,A carbohydrate metabolic disorder that involves a defect in galactose metabolism resulting in toxic levels of galactose 1-phosphate in various tissues.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9870,,,,SNOMEDCT_US_2016_03_01:190747003|SNOMEDCT_US_2016_03_01:154738008|ICD9CM:271.1|SNOMEDCT_US_2016_03_01:190749000|SNOMEDCT_US_2016_03_01:38177000|MESH:D005693|ICD10CM:E74.21|OMIM:230350|UMLS_CUI:C0016952|SNOMEDCT_US_2016_03_01:190745006|NCI:C84723|SNOMEDCT_US_2016_03_01:267498002|OMIM:230400,Galactosaemia|Galactose intolerance,,disease_ontology,,DOID:9870,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping by NeuroDevNet. [LS].,,galactosemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200027,"[""ASIC3 gene""]",,"This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400378,,,,,,,,"This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200027,,,,,,,,,,,,,,,,9311,ASIC3,ACCN3|SLNAC1|TNAC1,,,,,,,,,,ASIC3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100120,"[""Eukaryotic translation initiation factor 2-alpha kinase 3""]",,"A eukaryotic translation initiation factor 2-alpha kinase 3 that is encoded in the genome of human. [PRO:CNx, Reactome:REACT_18737] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300268,,,,,,,,"A eukaryotic translation initiation factor 2-alpha kinase 3 that is encoded in the genome of human. [PRO:CNx, Reactome:REACT_18737] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100120,,,,https://pharos.nih.gov/idg/targets/Q9NZJ5,,,,,,,,,,,,,EIF2AK3,PEK|PERK,,Q9NZJ5,,,,,,,,Eukaryotic translation initiation factor 2-alpha kinase 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100478,"[""Ste20-like serine/threonine-protein kinase""]",,"STE20-like serine/threonine-protein kinase (SLK)  with  no mutation  in a nonphosphorylated state|A STE20-like serine/threonine-protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H2G2] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300315,,,,,,,,"STE20-like serine/threonine-protein kinase (SLK)  with  no mutation  in a nonphosphorylated state|A STE20-like serine/threonine-protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H2G2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100478,,,,https://pharos.nih.gov/idg/targets/Q9H2G2,,,,,,,,,,,,,SLK,KIAA0204|STK2,,Q9H2G2,,,,,,,,Ste20-like serine/threonine-protein kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300446,"[""F subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300446,,,,,,,,,,,,,,,,,,,,,,,,,,,,F subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100331,"[""Olfactory receptor 11H2""]",,"An olfactory receptor 11H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH07] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 11H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH07] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100331,,,,https://pharos.nih.gov/idg/targets/Q8NH07,,,,,,,,,,,,,OR11H2,C14orf15|OR11H2P,,Q8NH07,,,,,,,,Olfactory receptor 11H2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100706,"[""Olfactory receptor 8K5""]",,"An olfactory receptor 8K5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH50] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 8K5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH50] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100706,,,,https://pharos.nih.gov/idg/targets/Q8NH50,,,,,,,,,,,,,OR8K5,,,Q8NH50,,,,,,,,Olfactory receptor 8K5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100155,"[""Tyrosine-protein kinase frk""]",,"A tyrosine-protein kinase FRK that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42685] |tyrosine-protein kinase frk (FRK)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300132,,,,,,,,"A tyrosine-protein kinase FRK that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42685] |tyrosine-protein kinase frk (FRK)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100155,,,,https://pharos.nih.gov/idg/targets/P42685,,,,,,,,,,,,,FRK,PTK5|RAK,,P42685,,,,,,,,Tyrosine-protein kinase frk,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100452,"[""Receptor-interacting serine/threonine-protein kinase 3""]",,"A receptor-interacting serine/threonine-protein kinase 3 that is encoded in the genome of human. [PRO:CNA, Reactome:REACT_22021] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300124,,,,,,,,"A receptor-interacting serine/threonine-protein kinase 3 that is encoded in the genome of human. [PRO:CNA, Reactome:REACT_22021] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100452,,,,https://pharos.nih.gov/idg/targets/Q9Y572,,,,,,,,,,,,,RIPK3,RIP3,,Q9Y572,,,,,,,,Receptor-interacting serine/threonine-protein kinase 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100179,"[""Calcium-activated potassium channel subunit beta-4""]",,"A calcium-activated potassium channel subunit beta-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86W47] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300441,,,,,,,,"A calcium-activated potassium channel subunit beta-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86W47] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100179,,,,https://pharos.nih.gov/idg/targets/Q86W47,,,,,,,,,,,,,KCNMB4,,,Q86W47,,,,,,,,Calcium-activated potassium channel subunit beta-4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300106,"[""TK group""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300102,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,TK group,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200268,"[""P2RX5 gene""]",,"The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream gene, TAX1BP3 (Tax1 binding protein 3). [provided by RefSeq, Mar 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400364,,,,,,,,"The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream gene, TAX1BP3 (Tax1 binding protein 3). [provided by RefSeq, Mar 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200268,,,,,,,,,,,,,,,,5026,P2RX5,P2X5,,,,,,,,,,P2RX5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200141,"[""GRIK3 gene""]",,"Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400418,,,,,,,,"Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200141,,,,,,,,,,,,,,,,2899,GRIK3,GLUR7,,,,,,,,,,GRIK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100286,"[""Mitogen-activated protein kinase kinase kinase 4""]",,"mitogen-activated protein kinase kinase kinase 4 (MAP3K4)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase kinase kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y6R4] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300186,,,,,,,,"mitogen-activated protein kinase kinase kinase 4 (MAP3K4)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase kinase kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y6R4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100286,,,,https://pharos.nih.gov/idg/targets/Q9Y6R4,,,,,,,,,,,,,MAP3K4,KIAA0213|MAPKKK4|MEKK4|MTK1,,Q9Y6R4,,,,,,,,Mitogen-activated protein kinase kinase kinase 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000329,"[""THR315 in ABL1(F317L)-nonphosphorylated""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000329,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR315 in ABL1(F317L)-nonphosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300063,"[""Mas proto-oncogene and Mas-related (MRGs) receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300063,,,,,,,,,,,,,,,,,,,,,,,,,,,,Mas proto-oncogene and Mas-related (MRGs) receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300409,"[""Glycine receptor subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300328,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300409,,,,,,,,,,,,,,,,,,,,,,,,,,,,Glycine receptor subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004974,"[""Hodgkin lymphoma cell""]",,A disease of the lymph nodes named after the English physician Thomas Hodgkin.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000785,,,,,,,,A disease of the lymph nodes named after the English physician Thomas Hodgkin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004974,Marion Gremse,2010-10-28T01:37:17Z,,,,,BrendaTissueOBO,,BTO:0004974,,,,,,,,,,,,,,,,,,,Hodgkin lymphoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400293,"[""JNK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400191,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400293,,,,,,,,,,,,,,,,,,,,,,,,,,,,JNK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100440,"[""Serine/threonine-protein kinase prp4 homolog""]",,"serine/threonine-protein kinase prp4 homolog (PRP4)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase PRP4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13523] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300150,,,,,,,,"serine/threonine-protein kinase prp4 homolog (PRP4)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase PRP4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13523] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100440,,,,https://pharos.nih.gov/idg/targets/Q13523,,,,,,,,,,,,,PRPF4B,KIAA0536|PRP4|PRP4H|PRP4K,,Q13523,,,,,,,,Serine/threonine-protein kinase prp4 homolog,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400283,"[""LIMK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400182,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400283,,,,,,,,,,,,,,,,,,,,,,,,,,,,LIMK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100505,"[""Olfactory receptor 1Q1""]",,"An olfactory receptor 1Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15612] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15612] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100505,,,,https://pharos.nih.gov/idg/targets/Q15612,,,,,,,,,,,,,OR1Q1,OR1Q2|OR1Q3,,Q15612,,,,,,,,Olfactory receptor 1Q1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100670,"[""Olfactory receptor 6t1""]",,"An olfactory receptor 6T1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6T1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100670,,,,https://pharos.nih.gov/idg/targets/Q8NGN1,,,,,,,,,,,,,OR6T1,,,Q8NGN1,,,,,,,,Olfactory receptor 6t1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200494,"[""OR1J4 gene""]",,"An olfactory receptor 1J4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1J4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200494,,,,,,,,,,,,,,,,26219,OR1J4,,,,,,,,,,,OR1J4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300211,"[""PLK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300211,,,,,,,,,,,,,,,,,,,,,,,,,,,,PLK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400236,"[""TOPK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400236,,,,,,,,,,,,,,,,,,,,,,,,,,,,TOPK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000260,"[""ciliary body""]",,"Tissue that includes the group of muscles that act on the eye lens to produce accommodation and the arterial circle of the iris. The inner ciliary epithelium is continuous with the pigmented retinal epithelium, the outer ciliary epithelium secretes the aqueous humour.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Tissue that includes the group of muscles that act on the eye lens to produce accommodation and the arterial circle of the iris. The inner ciliary epithelium is continuous with the pigmented retinal epithelium, the outer ciliary epithelium secretes the aqueous humour.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000260,,,,,,,BrendaTissueOBO,,BTO:0000260,,,,,,,,,,,,,,,,,,,ciliary body,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002974,"[""HEK-293-EBNA cell""]",,"Human embryonic kidney cell line, expressing EBNA.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Human embryonic kidney cell line, expressing EBNA.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002974,,,,,,,BrendaTissueOBO,293 EBNA cell|HEK-293E cell|293-EBNA cell|EBNA-293 cell|HEK293EBNA cell|293/EBNA cell|HEK 293 EBNA cell,BTO:0002974,,,,,,,,,,,,,,,,,,,HEK-293-EBNA cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200259,"[""GRIN2C gene""]",,"This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_01400457,,,,,,,,"This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200259,,,,,,,,,,,,,,,,2905,GRIN2C,NMDAR2C,,,,,,,,,,GRIN2C gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005612,"[""BL-6 cell""]",,Highly metastatic  murine  melanoma  overexpressing PKC delta BL6 (BL6T) and wild type (BL6) cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0000849|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Highly metastatic  murine  melanoma  overexpressing PKC delta BL6 (BL6T) and wild type (BL6) cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005612,Marion,2014-03-11T17:26:29Z,,,,,BrendaTissueOBO,BL6 cell,BTO:0005612,,,,,,,,,,,,,,,,,,,BL-6 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400271,"[""GRK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400127,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400271,,,,,,,,,,,,,,,,,,,,,,,,,,,,GRK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100089,"[""Adhesion G protein-coupled receptor E1""]",,"An EGF-like module-containing mucin-like hormone receptor-like 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14246] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,"An EGF-like module-containing mucin-like hormone receptor-like 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14246] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100089,,,,https://pharos.nih.gov/idg/targets/Q14246,,,,,,,,,,,,,EMR1,ADGRE1|TM7LN3,,Q14246,,,,,,,,Adhesion G protein-coupled receptor E1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100107,"[""Gamma-aminobutyric acid receptor subunit alpha-1""]",,"A gamma-aminobutyric acid receptor subunit alpha-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P14867] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300506,,,,,,,,"A gamma-aminobutyric acid receptor subunit alpha-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P14867] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100107,,,,https://pharos.nih.gov/idg/targets/P14867,,,,,,,,,,,,,GABRA1,,,P14867,,,,,,,,Gamma-aminobutyric acid receptor subunit alpha-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200115,"[""DYRK2 gene""]",," DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development.  The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues.  DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro.  Two isoforms of DYRK2 have been isolated.  The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400267,,,,,,,," DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development.  The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues.  DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro.  Two isoforms of DYRK2 have been isolated.  The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200115,,,,,,,,,,,,,,,,8445,DYRK2,,,,,,,,,,,DYRK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000418,"[""VAL170 in YANK3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000418,,,,,,,,,,,,,,,,,,,,,,,,,,,,VAL170 in YANK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80156,"[""Endomorphin-1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C15890,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80156,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80156,,,,,Endomorphin-1,,CHEBI:80156,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3969,"[""papillary thyroid carcinoma""]",,A thyroid carcinoma that is characterized by the small mushroom shape of the tumor which has a stem attached to the epithelial layer.,false,,,http://purl.obolibrary.org/obo/DOID_3963,,,,,,,,A thyroid carcinoma that is characterized by the small mushroom shape of the tumor which has a stem attached to the epithelial layer.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3969,,,,MESH:C536915|SNOMEDCT_US_2016_03_01:4797003|UMLS_CUI:C0238463|NCI:C4035|OMIM:188550|SNOMEDCT_US_2016_03_01:255029007,Papillary carcinoma of the Thyroid gland,,disease_ontology,,DOID:3969,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,papillary thyroid carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391021,"[""FGGY kinase family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300324,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391021,,,,,,,,,,,,,,,,,,,,,,,,,,,,FGGY kinase family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400259,"[""CCRK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400136,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400259,,,,,,,,,,,,,,,,,,,,,,,,,,,,CCRK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100208,"[""Probable G-protein coupled receptor 75""]",,"A G-protein coupled receptor 75 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95800] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 75 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95800] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100208,,,,https://pharos.nih.gov/idg/targets/O95800,,,,,,,,,,,,,GPR75,,,O95800,,,,,,,,Probable G-protein coupled receptor 75,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100699,"[""Olfactory receptor 8h3""]",,"An olfactory receptor 8H3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N146] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 8H3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N146] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100699,,,,https://pharos.nih.gov/idg/targets/Q8N146,,,,,,,,,,,,,OR8H3,,,Q8N146,,,,,,,,Olfactory receptor 8h3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000198,"[""PYY-(3-36)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000198,,,,,,,,,,,,,,,,,,,,,,,,,,,,PYY-(3-36),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300379,"[""Acid-sensing ion channel 4 (ASIC4) subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300330,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300379,,,,,,,,,,,,,,,,,,,,,,,,,,,,Acid-sensing ion channel 4 (ASIC4) subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400497,"[""Alpha-9/CHRNA9 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400497,,,,,,,,,,,,,,,,,,,,,,,,,,,,Alpha-9/CHRNA9 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_67119,"[""UDP-alpha-D-galactose""]","HSCJRCZFDFQWRP-ABVWGUQPSA-N|
OC[C@H]1O[C@H](OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@H](O)[C@@H](O)[C@H]1O
|UDP-alpha-D-galactopyranose|Uridine diphosphate galactose|C15H24N2O17P2|Uridine pyrophosphogalactose|Udp galactose|UDP-D-galactopyranose|
InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/t5-,6-,8+,9-,10+,11-,12-,13-,14-/m1/s1
|Uridinediphosphogalactose|UDP-galactose|Uridine diphosphogalactose","
A UDP-D-galactose in which the anomeric centre of the galactose moiety has alpha-configuration.
",false,,,http://purl.obolibrary.org/obo/CHEBI_36976,,,,,,,KNApSAcK:C00007390|KEGG COMPOUND:C00052|KEGG COMPOUND:2956-16-3|ChemIDplus:2956-16-3|KEGG GLYCAN:G10609|PDBeChem:GDU|Reaxys:102009,"
A UDP-D-galactose in which the anomeric centre of the galactose moiety has alpha-configuration.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,"
uridine 5'-[3-(alpha-D-galactopyranosyl) dihydrogen diphosphate]
",,chebi_ontology,"HSCJRCZFDFQWRP-ABVWGUQPSA-N|
OC[C@H]1O[C@H](OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@H](O)[C@@H](O)[C@H]1O
|UDP-alpha-D-galactopyranose|Uridine diphosphate galactose|C15H24N2O17P2|Uridine pyrophosphogalactose|Udp galactose|UDP-D-galactopyranose|
InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/t5-,6-,8+,9-,10+,11-,12-,13-,14-/m1/s1
|Uridinediphosphogalactose|UDP-galactose|Uridine diphosphogalactose",,,CHEBI:67119,,,,,,,,,,,,,,,,,,,,,,,CHEBI:67119,,,,,UDP-galactose|UDP-alpha-D-galactose,,CHEBI:67119,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200419,"[""PIM3 gene""]",,"The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is overexpressed in hematological and epithelial tumors and is associated with MYC coexpression. It plays a role in the regulation of signal transduction cascades, contributing to both cell proliferation and survival, and provides a selective advantage in tumorigenesis. [provided by RefSeq, Jun 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400207,,,,,,,,"The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is overexpressed in hematological and epithelial tumors and is associated with MYC coexpression. It plays a role in the regulation of signal transduction cascades, contributing to both cell proliferation and survival, and provides a selective advantage in tumorigenesis. [provided by RefSeq, Jun 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200419,,,,,,,,,,,,,,,,415116,PIM3,,,,,,,,,,,PIM3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117504,"[""Nuclear receptor subfamily 2 group c member 1""]",,"A nuclear receptor subfamily 2 group C member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P13056] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117469,,,,,,,,"A nuclear receptor subfamily 2 group C member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P13056] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117504,,,,https://pharos.nih.gov/idg/targets/P13056,,,,,,,,,,,,,NR2C1,,,P13056,,,,,,,,Nuclear receptor subfamily 2 group c member 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100343,"[""Olfactory receptor 13C5""]",,"An olfactory receptor 13C5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 13C5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100343,,,,https://pharos.nih.gov/idg/targets/Q8NGS8,,,,,,,,,,,,,OR13C5,,,Q8NGS8,,,,,,,,Olfactory receptor 13C5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001827,"[""tail fin""]",,"A fin at the posterior part of the body of a fish, crustacean, whale, or other aquatic animal.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0004649,,,,,,,,"A fin at the posterior part of the body of a fish, crustacean, whale, or other aquatic animal.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001827,,,,,,,BrendaTissueOBO,tailfin|caudal fin,BTO:0001827,,,,,,,,,,,,,,,,,,,tail fin,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13268,"[""porphyria""]",,An inherited metabolic disorder that involves certain enzymes in the heme bio-synthetic pathway resulting in the overproduction and accumulation of the porphyrins.,false,,,http://purl.obolibrary.org/obo/DOID_655,,,,,,,,An inherited metabolic disorder that involves certain enzymes in the heme bio-synthetic pathway resulting in the overproduction and accumulation of the porphyrins.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13268,,,,MESH:D011164|SNOMEDCT_US_2016_03_01:371628009|SNOMEDCT_US_2016_03_01:274090006|NCI:C97096|SNOMEDCT_US_2016_03_01:29094004|ICD9CM:277.1|SNOMEDCT_US_2016_03_01:238052001|SNOMEDCT_US_2016_03_01:86292002|SNOMEDCT_US_2016_03_01:418470004|SNOMEDCT_US_2016_03_01:190916001|ICD10CM:E80.20|SNOMEDCT_US_2016_03_01:190912004|SNOMEDCT_US_2016_03_01:154768004|UMLS_CUI:C0032708,disorder of porphyrin metabolism|Porphyrinopathy|disorder of porphyrin and hem metabolism|Hematoporphyria,,disease_ontology,,DOID:13268,,,,,,,,,,,,,,,,,,,porphyria,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001544,"[""chronic myeloid leukemia cell""]",,"Neoplasia of myeloid stem cells, commonest in middle-aged or elderly people, characterized by excessive numbers of circulating leucocytes, most commonly neutrophils (or precursors), but occasionally eosinophils or basophils.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001056,,,,,,,,"Neoplasia of myeloid stem cells, commonest in middle-aged or elderly people, characterized by excessive numbers of circulating leucocytes, most commonly neutrophils (or precursors), but occasionally eosinophils or basophils.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001544,,,,,,,BrendaTissueOBO,CML cell|cronic myelogenous leukemia cell,BTO:0001544,,,,,,,,,,,,,,,,,,,chronic myeloid leukemia cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200151,"[""FGFR3 gene""]",,"This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400158,,,,,,,,"This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200151,,,,,,,,,,,,,,,,2261,FGFR3,JTK4,,,,,,,,,,FGFR3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100188,"[""Probable g-protein coupled receptor 27""]",,"A G-protein coupled receptor 27 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NS67] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 27 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NS67] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100188,,,,https://pharos.nih.gov/idg/targets/Q9NS67,,,,,,,,,,,,,GPR27,SREB1,,Q9NS67,,,,,,,,Probable g-protein coupled receptor 27,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100094,"[""Casein kinase ii subunit beta""]",,A casein kinase II subunit beta that is encoded in the genome of human. ,false,,,http://www.drugtargetontology.org/dto/DTO_03300142,,,,,,,,A casein kinase II subunit beta that is encoded in the genome of human. ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100094,,,,https://pharos.nih.gov/idg/targets/P67870,,,,,,,,,,,,,CSNK2B,CK2N|G5A,,P67870,,,,,,,,Casein kinase ii subunit beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001368,"[""thorax""]",,1: The part of the mammalian body between the neck and the abdomen; also: its cavity in which the heart and lungs lie. 2: The middle of the three chief divisions of the body of an insect; also: the corresponding part of a crustacean or an arachnid.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,1: The part of the mammalian body between the neck and the abdomen; also: its cavity in which the heart and lungs lie. 2: The middle of the three chief divisions of the body of an insect; also: the corresponding part of a crustacean or an arachnid.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001368,,,,,,,BrendaTissueOBO,chest,BTO:0001368,,,,,,,,,,,,,,,,,,,thorax,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5768,"[""Nager acrofacial dysostosis""]",,"An acrofacial dysostosis characterized by underdeveloped cheek bones, very small lower jaw, cleft palate, defects in the middle ear, absent eyelashes, and a notch in the lower eyelids called a coloboma, in children.",false,,,http://purl.obolibrary.org/obo/DOID_0060379,,,,,,,,"An acrofacial dysostosis characterized by underdeveloped cheek bones, very small lower jaw, cleft palate, defects in the middle ear, absent eyelashes, and a notch in the lower eyelids called a coloboma, in children.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5768,,,,NCI:C35795|UMLS_CUI:C1332140|OMIM:154400,"AFD|preaxial manibulofacial dysostosis|preaxial acrofacial dysostosis|acrofacial dysostosis 1, Nager type|Nager syndrome",,disease_ontology,,DOID:5768,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Nager acrofacial dysostosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001158,"[""rectum""]",,The terminal part of the intestine from the sigmoid flexure to the anus.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The terminal part of the intestine from the sigmoid flexure to the anus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001158,,,,,,,BrendaTissueOBO,intestinum rectum,BTO:0001158,,,,,,,,,,,,,,,,,,,rectum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002064,"[""stromal cell""]",,Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002064,,,,,,,BrendaTissueOBO,,BTO:0002064,,,,,,,,,,,,,,,,,,,stromal cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100026,"[""K255 in ABL1(E255K)-phosphorylated""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100026,,,,,,,,,,,,,,,,,,,,,,,,,,,,K255 in ABL1(E255K)-phosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300519,"[""GABRG3 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300519,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRG3 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200556,"[""OR2W3 gene""]",,"An olfactory receptor 2W3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z3T1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2W3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z3T1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200556,,,,,,,,,,,,,,,,343171,OR2W3,OR2W3P|OR2W8P,,,,,,,,,,OR2W3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005049,"[""prostate adenocarcinoma cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0000167|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001033,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005049,XPMUser,2011-03-05T08:56:21Z,,,,,BrendaTissueOBO,,BTO:0005049,,,,,,,,,,,,,,,,,,,prostate adenocarcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000066,"[""QRFP""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000066,,,,,,,,,,,,,,,,,,,,,,,,,,,,QRFP,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300343,"[""Cyclic nucleotide-gated cation channel family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300343,,,,,,,,,,,,,,,,,,,,,,,,,,,,Cyclic nucleotide-gated cation channel family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000367,"[""THR663 in CSF1R-autoinhibited""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000367,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR663 in CSF1R-autoinhibited,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400474,"[""Nav1.7/SCN9A subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400369,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400474,,,,,,,,,,,,,,,,,,,,,,,,,,,,Nav1.7/SCN9A subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100184,"[""Potassium voltage-gated channel subfamily a member 5""]",,A voltage-gated potassium channel subunit KCNA5 that is encoded in the genome of human. [] ,false,,,http://www.drugtargetontology.org/dto/DTO_01300536,,,,,,,,A voltage-gated potassium channel subunit KCNA5 that is encoded in the genome of human. [] ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100184,,,,https://pharos.nih.gov/idg/targets/P22460,,,,,,,,,,,,,KCNA5,,,P22460,,,,,,,,Potassium voltage-gated channel subfamily a member 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100404,"[""Platelet-derived growth factor receptor beta""]",,"platelet-derived growth factor receptor beta (PGFRB)  with  no mutation  in a nonphosphorylated state|A beta-type platelet-derived growth factor receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P09619] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300141,,,,,,,,"platelet-derived growth factor receptor beta (PGFRB)  with  no mutation  in a nonphosphorylated state|A beta-type platelet-derived growth factor receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P09619] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100404,,,,https://pharos.nih.gov/idg/targets/P09619,,,,,,,,,,,,,PDGFRB,PDGFR|PDGFR1,,P09619,,,,,,,,Platelet-derived growth factor receptor beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100458,"[""Macrophage-stimulating protein receptor""]",,"macrophage-stimulating protein receptor (MST1R)  with  no mutation  in a nonphosphorylated state|A macrophage-stimulating protein receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q04912] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300190,,,,,,,,"macrophage-stimulating protein receptor (MST1R)  with  no mutation  in a nonphosphorylated state|A macrophage-stimulating protein receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q04912] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100458,,,,https://pharos.nih.gov/idg/targets/Q04912,,,,,,,,,,,,,MST1R,PTK8|RON,,Q04912,,,,,,,,Macrophage-stimulating protein receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100165,"[""Probable G-protein coupled receptor 174""]",,"A G-protein coupled receptor 174 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BXC1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 174 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BXC1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100165,,,,https://pharos.nih.gov/idg/targets/Q9BXC1,,,,,,,,,,,,,GPR174,,,Q9BXC1,,,,,,,,Probable G-protein coupled receptor 174,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300588,"[""TRPM7 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300483,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300588,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPM7 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400524,"[""GABRQ sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400524,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRQ sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400471,"[""Nav1.5/SCN5A subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400369,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400471,,,,,,,,,,,,,,,,,,,,,,,,,,,,Nav1.5/SCN5A subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4310,"[""smooth muscle tumor""]",,,false,,,http://purl.obolibrary.org/obo/DOID_461,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4310,,,,SNOMEDCT_US_2016_03_01:189799007|MESH:D018235|SNOMEDCT_US_2016_03_01:75109009|NCI:C3751|UMLS_CUI:C0206658,neoplasm of the Smooth Muscle|Smooth muscle tumour of uncertain malignant potential| Smooth muscle tumor NOS (morphologic abnormality),,disease_ontology,,DOID:4310,,,,,,,,,,,,,,,,,,,smooth muscle tumor,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100332,"[""Mapk/mak/mrk overlapping kinase""]",,"A MAPK/MAK/MRK overlapping kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UQ07] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300162,,,,,,,,"A MAPK/MAK/MRK overlapping kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UQ07] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100332,,,,https://pharos.nih.gov/idg/targets/Q9UQ07,,,,,,,,,,,,,MOK,RAGE|RAGE1,,Q9UQ07,,,,,,,,Mapk/mak/mrk overlapping kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000094,"[""MET105 in MAP4K4""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000094,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET105 in MAP4K4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002354,"[""talus""]",,The highest of the tarsal bones and the one that articulates with the tibia and fibula to form the ankle joint.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002343,,,,,,,,The highest of the tarsal bones and the one that articulates with the tibia and fibula to form the ankle joint.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002354,,,,,,,BrendaTissueOBO,ankle|astragalus|ankle bone|astragaloid bone|os tarsi tibiale,BTO:0002354,,,,,,,,,,,,,,,,,,,talus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000045,"[""AURKB kinase domain""]",,Aurora kinase B; AIK2; AIM1; AIM-1; ARK2; Aur1; AurB; AurB/Aur1; AURKB; aurkb-sv1; aurkb-sv2; IPL1; STK12; STK5,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Aurora kinase B; AIK2; AIM1; AIM-1; ARK2; Aur1; AurB; AurB/Aur1; AURKB; aurkb-sv1; aurkb-sv2; IPL1; STK12; STK5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000045,,,,,,,,,,,,,,,,,,,200045,,,,,,,,,AURKB kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100355,"[""Serine/threonine-protein kinase nek1""]",,"A serine/threonine-protein kinase Nek1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96PY6] |serine/threonine-protein kinase nek1 (NEK1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300197,,,,,,,,"A serine/threonine-protein kinase Nek1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96PY6] |serine/threonine-protein kinase nek1 (NEK1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100355,,,,https://pharos.nih.gov/idg/targets/Q96PY6,,,,,,,,,,,,,NEK1,KIAA1901,,Q96PY6,,,,,,,,Serine/threonine-protein kinase nek1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100052,"[""Calcium homeostasis modulator protein 1""]",,"A calcium homeostasis modulator protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IU99] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300335,,,,,,,,"A calcium homeostasis modulator protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IU99] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100052,,,,https://pharos.nih.gov/idg/targets/Q8IU99,,,,,,,,,,,,,CALHM1,FAM26C,,Q8IU99,,,,,,,,Calcium homeostasis modulator protein 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9971,"[""hypervitaminosis D""]",,,false,,,http://purl.obolibrary.org/obo/DOID_654,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9971,,,,ICD10CM:E67.3|UMLS_CUI:C1442839|ICD9CM:278.4|SNOMEDCT_US_2016_03_01:27712000|SNOMEDCT_US_2016_03_01:190969000,,,disease_ontology,,DOID:9971,,,,,,,,,,,,,,,,,,,hypervitaminosis D,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117466,"[""Vitamin d receptor-like receptors""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00102000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117466,,,,,,,,,,,,,,,,,,,,,,,,,,,,Vitamin d receptor-like receptors,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200367,"[""OR2AT4 gene""]",,"An olfactory receptor 2AT4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NND4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2AT4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NND4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200367,,,,,,,,,,,,,,,,341152,OR2AT4,,,,,,,,,,,OR2AT4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000139,"[""MET174 in CIT""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000139,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET174 in CIT,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002913,"[""epithelioma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002913,,,,,,,BrendaTissueOBO,,BTO:0002913,,,,,,,,,,,,,,,,,,,epithelioma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200778,"[""TAS2R14 gene""]",,"A taste receptor type 2 member 14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYV8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400014,,,,,,,,"A taste receptor type 2 member 14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYV8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200778,,,,,,,,,,,,,,,,50840,TAS2R14,,,,,,,,,,,TAS2R14 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001460,"[""thymic cancer cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001460,,,,,,,BrendaTissueOBO,,BTO:0001460,,,,,,,,,,,,,,,,,,,thymic cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100287,"[""Mitogen-activated protein kinase kinase kinase 5""]",,"A mitogen-activated protein kinase kinase kinase 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99683] |mitogen-activated protein kinase kinase kinase 5 (M3K5)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300186,,,,,,,,"A mitogen-activated protein kinase kinase kinase 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99683] |mitogen-activated protein kinase kinase kinase 5 (M3K5)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100287,,,,https://pharos.nih.gov/idg/targets/Q99683,,,,,,,,,,,,,MAP3K5,ASK1|MAPKKK5|MEKK5,,Q99683,,,,,,,,Mitogen-activated protein kinase kinase kinase 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000239,"[""PHE104 in PHKG1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000239,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE104 in PHKG1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100669,"[""Olfactory receptor 6S1""]",,"An olfactory receptor 6S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH40] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH40] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100669,,,,https://pharos.nih.gov/idg/targets/Q8NH40,,,,,,,,,,,,,OR6S1,,,Q8NH40,,,,,,,,Olfactory receptor 6S1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300341,"[""Chloride channel family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300341,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chloride channel family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_720,"[""normocytic anemia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:720,,,,UMLS_CUI:C0085577|NCI:C35142|SNOMEDCT_US_2016_03_01:300980002,ANEMIA NORMOCYTIC|Normocytic anemia (disorder),,disease_ontology,,DOID:720,,,,,,,,,,,,,,,,,,,normocytic anemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003165,"[""cervical adenocarcinoma cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000180|http://purl.obolibrary.org/obo/BTO_0000604,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003165,,,,,,,BrendaTissueOBO,,BTO:0003165,,,,,,,,,,,,,,,,,,,cervical adenocarcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200106,"[""FXYD6P3 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400348,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200106,,,,,,,,,,,,,,,,406875,FXYD6P3,FXYD8,,,,,,,,,,FXYD6P3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100519,"[""Olfactory receptor 2C3""]",,"An olfactory receptor 2C3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N628] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2C3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N628] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100519,,,,https://pharos.nih.gov/idg/targets/Q8N628,,,,,,,,,,,,,OR2C3,OR2C4|OR2C5P,,Q8N628,,,,,,,,Olfactory receptor 2C3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200046,"[""C5AR1 gene""]",,"A C5a anaphylatoxin chemotactic receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21730] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400027,,,,,,,,"A C5a anaphylatoxin chemotactic receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21730] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200046,,,,,,,,,,,,,,,,728,C5AR1,C5AR|C5R1,,,,,,,,,,C5AR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11612,"[""polycystic ovary syndrome""]",,"A syndrome characterized by hyperandrogenism, polycystic ovaries, hirsutism, oligomenorrhea or amenorrhea, anovulation and excessive body weight.",false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,"A syndrome characterized by hyperandrogenism, polycystic ovaries, hirsutism, oligomenorrhea or amenorrhea, anovulation and excessive body weight.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11612,,,,UMLS_CUI:C0032460|SNOMEDCT_US_2016_03_01:154714009|EFO:0000660|SNOMEDCT_US_2016_03_01:237792009|SNOMEDCT_US_2016_03_01:237055002|ICD10CM:E28.2|NCI:C26862|OMIM:184700|SNOMEDCT_US_2016_03_01:190549002|MESH:D011085|ICD9CM:256.4|SNOMEDCT_US_2016_03_01:271199009|SNOMEDCT_US_2016_03_01:69878008,Stein-Leventhal synd.|Multicystic ovaries|Stein-Leventhal syndrome|PCOS|Polycystic ovaries (disorder)|Polycystic ovary syndrome|polycystic ovary|Polycystic Ovarian disease|Polycystic ovaries,,disease_ontology,,DOID:11612,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,polycystic ovary syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11613,"[""hyperandrogenism""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1923,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11613,,,,UMLS_CUI:C0206081|MESH:D017588|SNOMEDCT_US_2016_03_01:237793004,hyperandrogenization syndrome,,disease_ontology,,DOID:11613,,,,,,,,,,,,,,,,,,,hyperandrogenism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4467,"[""renal clear cell carcinoma""]",,A renal cell carcinoma that has_material_basis_in cells that appear very pale or clear when examined under microscope.,false,,,http://purl.obolibrary.org/obo/DOID_4450,,,,,,,,A renal cell carcinoma that has_material_basis_in cells that appear very pale or clear when examined under microscope.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4467,,,,SNOMEDCT_US_2016_03_01:254915003|NCI:C4033|SNOMEDCT_US_2016_03_01:188251003|SNOMEDCT_US_2016_03_01:41607009|MESH:D002292|UMLS_CUI:C0279702,conventional (Clear cell) renal cell carcinoma|conventional renal cell carcinoma|Clear cell carcinoma of kidney (disorder)|clear cell kidney carcinoma,,disease_ontology,Clear-cell metastatic renal cell carcinoma,DOID:4467,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,MESH:C538445 added from NeuroDevNet [WAK].,,renal clear cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300252,"[""STKR Type 2 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300119,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300252,,,,,,,,,,,,,,,,,,,,,,,,,,,,STKR Type 2 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_998,"[""eosinophilia-myalgia syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_999,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:998,,,,SNOMEDCT_US_2016_03_01:95416007|MESH:D016603|UMLS_CUI:C0085179|ICD9CM:710.5,Eosinophilia myalgia syndrome,,disease_ontology,,DOID:998,,,,,,,,,,,,,,,,,,,eosinophilia-myalgia syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_999,"[""hypereosinophilic syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_9500,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:999,,,,MESH:D017681|ICD10CM:D72.1|MESH:D004802|SNOMEDCT_US_2016_03_01:418928000|ICD9CM:288.3|UMLS_CUI:C0014457|SNOMEDCT_US_2016_03_01:191363000|SNOMEDCT_US_2016_03_01:27955006|SNOMEDCT_US_2016_03_01:165524009,eosinophilia|Eosinophilic leukocytosis,,disease_ontology,,DOID:999,,,,,,,,,,,,,,,,,,,hypereosinophilic syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300358,"[""Calcium-activated potassium channel auxiliary subunit slowpoke- (slo) family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300358,,,,,,,,,,,,,,,,,,,,,,,,,,,,Calcium-activated potassium channel auxiliary subunit slowpoke- (slo) family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9682,"[""yellow fever""]",,"A viral infectious disease that results_in infection, has_material_basis_in Yellow fever virus, which is transmitted_by Aedes, transmitted_by Haemagogus, or transmitted_by Sabethes species of mosquitoes. The infection has_symptom fever, has_symptom muscle pain, has_symptom backache, has_symptom headache, has_symptom shivers, has_symptom loss of appetite, has_symptom jaundice, and has_symptom bleeding from the mouth, nose, eyes or stomach leading to vomitus containing blood.",false,,,http://purl.obolibrary.org/obo/DOID_37|http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in infection, has_material_basis_in Yellow fever virus, which is transmitted_by Aedes, transmitted_by Haemagogus, or transmitted_by Sabethes species of mosquitoes. The infection has_symptom fever, has_symptom muscle pain, has_symptom backache, has_symptom headache, has_symptom shivers, has_symptom loss of appetite, has_symptom jaundice, and has_symptom bleeding from the mouth, nose, eyes or stomach leading to vomitus containing blood.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9682,,,DOID:9683|DOID:9684,NCI:C35547|ICD9CM:060.9|ICD10CM:A95.9|SNOMEDCT_US_2016_03_01:187411002|MESH:D015004|SNOMEDCT_US_2016_03_01:16541001|ICD9CM:060|UMLS_CUI:C0043395|SNOMEDCT_US_2016_03_01:186587002|SNOMEDCT_US_2016_03_01:266194002|ICD10CM:A95|SNOMEDCT_US_2016_03_01:154345006,"jungle yellow fever|urban yellow fever|Sylvatic yellow fever|Yellow fever, sylvan",,disease_ontology,,DOID:9682,http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,yellow fever,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000199,"[""MET737 in PKN2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000199,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET737 in PKN2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000273,"[""MK03 kinase domain""]",,Mitogen-activated protein kinase 3; ERK1; HS44KDAP; HUMKER1A; MAPK3; MGC20180; P44ERK1; P44MAPK; PRKM3,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase 3; ERK1; HS44KDAP; HUMKER1A; MAPK3; MGC20180; P44ERK1; P44MAPK; PRKM3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000273,,,,,,,,,,,,,,,,,,,200151,,,,,,,,,MK03 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050952,"[""spastic ataxia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0050951,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050952,lschriml,2015-10-05T14:39:34Z,,,,,disease_ontology,,DOID:0050952,,,,,,,,,,,,,,,,,,,spastic ataxia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050950,"[""autosomal recessive cerebellar ataxia""]",,A hereditary ataxia that has_material_basis_in autosomal recessive inheritance.,false,,,http://purl.obolibrary.org/obo/DOID_0050951,,,,,,,,A hereditary ataxia that has_material_basis_in autosomal recessive inheritance.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050950,lschriml,2015-10-05T14:21:08Z,,,,,disease_ontology,,DOID:0050950,,,,,,,,,,,,,,,,,,,autosomal recessive cerebellar ataxia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050951,"[""hereditary ataxia""]",,"A neurodegenerative disease that is characterized by slowly progressive incoordination of gait and often associated with poor coordination of hands, speech, and eye movements.",false,,,http://purl.obolibrary.org/obo/DOID_1289,,,,,,,,"A neurodegenerative disease that is characterized by slowly progressive incoordination of gait and often associated with poor coordination of hands, speech, and eye movements.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050951,lschriml,2015-10-05T14:38:17Z,,,,,disease_ontology,,DOID:0050951,,,,,,,,,,,,,,,,,,,hereditary ataxia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050955,"[""spinocerebellar ataxia type 2""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1441,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050955,lschriml,2015-10-05T16:07:27Z,,OMIM:183090,,,disease_ontology,,DOID:0050955,,,,,,,,,,,,,,,,,,,spinocerebellar ataxia type 2,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050958,"[""spinocerebellar ataxia type 7""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1441,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050958,lschriml,2015-10-05T16:07:27Z,,OMIM:164500,,,disease_ontology,,DOID:0050958,,,,,,,,,,,,,,,,,,,spinocerebellar ataxia type 7,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100082,"[""Serine/threonine-protein kinase chk1""]",,A serine/threonine-protein kinase CHK1 that is encoded in the genome of humans. [PRO:CNA] |serine/threonine-protein kinase chk1 (CHEK1)  with  no mutation  in a nonphosphorylated state,false,,,http://www.drugtargetontology.org/dto/DTO_03300264,,,,,,,,A serine/threonine-protein kinase CHK1 that is encoded in the genome of humans. [PRO:CNA] |serine/threonine-protein kinase chk1 (CHEK1)  with  no mutation  in a nonphosphorylated state,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100082,,,,https://pharos.nih.gov/idg/targets/O14757,,,,,,,,,,,,,CHEK1,CHK1,,O14757,,,,,,,,Serine/threonine-protein kinase chk1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100187,"[""G-protein coupled receptor 26""]",,"A G-protein coupled receptor 26 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8NDV2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 26 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8NDV2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100187,,,,https://pharos.nih.gov/idg/targets/Q8NDV2,,,,,,,,,,,,,GPR26,,,Q8NDV2,,,,,,,,G-protein coupled receptor 26,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003646,"[""pleomorphic adenoma cell""]",,"Carcinoma arising in a benign mixed tumour of a salivary gland, characterised by rapid enlargement and pain.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002773,,,,,,,,"Carcinoma arising in a benign mixed tumour of a salivary gland, characterised by rapid enlargement and pain.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003646,,,,,,,BrendaTissueOBO,carcinoma ex pleomorphic adenoma,BTO:0003646,,,,,,,,,,,,,,,,,,,pleomorphic adenoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400161,"[""HASPIN family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400161,,,,,,,,,,,,,,,,,,,,,,,,,,,,HASPIN family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_29972,"[""L-glutamic acid residue""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_33700,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:29972,,,,RESID:AA0006,L-glutamic acid residue,,chebi_ontology,129.11402|C5H7NO3|L-glutamic residue|E|-Glu-|129.043|L-glutamic acid|0|Glu|L-glutamyl,CHEBI:29972,http://purl.obolibrary.org/obo/chebi#3_STAR,,,,,,,,,,,,,,,,,,L-glutamic acid residue,,,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100027,"[""K542 in PIK3CA(E542K)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100027,,,,,,,,,,,,,,,,,,,,,,,,,,,,K542 in PIK3CA(E542K),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000019,"[""ILE1323 in MAP3K1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30009,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000019,,,,,,,,,,,,,,,,,,,,,,,,,,,,ILE1323 in MAP3K1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100047,"[""Voltage-dependent l-type calcium channel subunit alpha-1s""]",,"A voltage-dependent L-type calcium channel subunit alpha-1S that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13698] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300390,,,,,,,,"A voltage-dependent L-type calcium channel subunit alpha-1S that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13698] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100047,,,,https://pharos.nih.gov/idg/targets/Q13698,,,,,,,,,,,,,CACNA1S,CACH1|CACN1|CACNL1A3,,Q13698,,,,,,,,Voltage-dependent l-type calcium channel subunit alpha-1s,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200297,"[""OR10C1 gene""]",,"An olfactory receptor 10C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96KK4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96KK4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200297,,,,,,,,,,,,,,,,442194,OR10C1,OR10C2,,,,,,,,,,OR10C1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300453,"[""NR3A/GRIN3A subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300453,,,,,,,,,,,,,,,,,,,,,,,,,,,,NR3A/GRIN3A subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300303,"[""PAKA subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300187,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300303,,,,,,,,,,,,,,,,,,,,,,,,,,,,PAKA subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400553,"[""Kv10.1/KCNH1 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400448,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400553,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv10.1/KCNH1 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000158,"[""MET304 in CTK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000158,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET304 in CTK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100296,"[""Olfactory receptor 10AG1""]",,"An olfactory receptor 10AG1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH19] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10AG1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH19] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100296,,,,https://pharos.nih.gov/idg/targets/Q8NH19,,,,,,,,,,,,,OR10AG1,,,Q8NH19,,,,,,,,Olfactory receptor 10AG1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003718,"[""vasculature""]",,The blood vessels or arrangement of blood vessels in an organ or part.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The blood vessels or arrangement of blood vessels in an organ or part.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003718,,,,,,,BrendaTissueOBO,,BTO:0003718,,,,,,,,,,,,,,,,,,,vasculature,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100160,"[""Inward rectifier potassium channel 4""]",,"An inward rectifier potassium channel 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48050] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300431,,,,,,,,"An inward rectifier potassium channel 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48050] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100160,,,,https://pharos.nih.gov/idg/targets/P48050,,,,,,,,,,,,,KCNJ4,IRK3,,P48050,,,,,,,,Inward rectifier potassium channel 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050152,"[""aspiration pneumonia""]",,A bacterial pneumonia which is an acute pulmonary inflammatory response that develops after the inhalation of colonized oropharyngeal material containing bacteria. It is seen in individuals with dysphagia and gastric dysmotility. The disease has_symptom tachypnea and has_symptom cough.,false,,,http://purl.obolibrary.org/obo/DOID_874,,,,,,,,A bacterial pneumonia which is an acute pulmonary inflammatory response that develops after the inhalation of colonized oropharyngeal material containing bacteria. It is seen in individuals with dysphagia and gastric dysmotility. The disease has_symptom tachypnea and has_symptom cough.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050152,,,,ICD10CM:J69.0|SNOMEDCT_US_2016_03_01:47839005|SNOMEDCT_US_2016_03_01:422588002|UMLS_CUI:C0032290|MESH:D011015,,,disease_ontology,,DOID:0050152,,,,,,,,,,,,,,,,,,,aspiration pneumonia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050156,"[""idiopathic pulmonary fibrosis""]",,"An idiopathic interstitial pneumonia which is a distinctive type of chronic fibrosing interstitial pneumonia with thick scarring in the lung creating a honeycomb appearance. The main symptoms start insidiously as shortness of breath on exertion, cough, and diminished stamina. Other common complaints include weight loss and fatigue. The level of oxygen in the blood decreases, and the skin may take on a bluish tinge (called cyanosis) and the ends of the fingers may become thick or club-shape. In most people, symptoms worsen over a period ranging from about 6 months to several years.",false,,,http://purl.obolibrary.org/obo/DOID_2797,,,,,,,,"An idiopathic interstitial pneumonia which is a distinctive type of chronic fibrosing interstitial pneumonia with thick scarring in the lung creating a honeycomb appearance. The main symptoms start insidiously as shortness of breath on exertion, cough, and diminished stamina. Other common complaints include weight loss and fatigue. The level of oxygen in the blood decreases, and the skin may take on a bluish tinge (called cyanosis) and the ends of the fingers may become thick or club-shape. In most people, symptoms worsen over a period ranging from about 6 months to several years.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050156,,,,SNOMEDCT_US_2016_03_01:196125002|MESH:D054990|SNOMEDCT_US_2016_03_01:233721005|SNOMEDCT_US_2016_03_01:28168000|EFO:0000768|NCI:C35716|ICD9CM:516.31|UMLS_CUI:C1800706|SNOMEDCT_US_2016_03_01:426437004|OMIM:178500|NCI:C35715|SNOMEDCT_US_2016_03_01:237121003|ICD10CM:J84.112,"FIBROCYSTIC PULMONARY DYSPLASIA|IDIOPATHIC PULMONARY FIBROSIS, FAMILIAL|cryptogenic fibrosing alveolitis",,disease_ontology,,DOID:0050156,http://purl.obolibrary.org/obo/doid#NCIthesaurus,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,idiopathic pulmonary fibrosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050155,"[""sensory system disease""]",,"A nervous system disease which is located in a part of the nervous system responsible for processing sensory information that consists of sensory receptors, neural pathways, and parts of the brain involved in sensory perception. Commonly recognized sensory systems are those for vision, hearing, somatic sensation (touch), taste and olfaction (smell).",false,,,http://purl.obolibrary.org/obo/DOID_863,,,,,,,,"A nervous system disease which is located in a part of the nervous system responsible for processing sensory information that consists of sensory receptors, neural pathways, and parts of the brain involved in sensory perception. Commonly recognized sensory systems are those for vision, hearing, somatic sensation (touch), taste and olfaction (smell).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050155,,,,,,,disease_ontology,,DOID:0050155,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,sensory system disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200065,"[""CDK19 gene""]",,"This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400257,,,,,,,,"This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200065,,,,,,,,,,,,,,,,23097,CDK19,CDC2L6|CDK11|KIAA1028,,,,,,,,,,CDK19 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000331,"[""PDPK1 kinase domain""]",,3-phosphoinositide dependent protein kinase-1; MGC20087; MGC35290; PDK1; PDPK1; PRO0461,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,3-phosphoinositide dependent protein kinase-1; MGC20087; MGC35290; PDK1; PDPK1; PRO0461,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000331,,,,,,,,,,,,,,,,,,,200314,,,,,,,,,PDPK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200565,"[""OR4A4P gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200565,,,,,,,,,,,,,,,,390134,OR4A4P,,,,,,,,,,,OR4A4P gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004744,"[""hair cell""]",,"Hair cells are the sensory receptors of both the auditory system and the vestibular system in all vertebrates. In mammals, the auditory hair cells are located within the organ of Corti on a thin basilar membrane in the cochlea of the inner ear.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Hair cells are the sensory receptors of both the auditory system and the vestibular system in all vertebrates. In mammals, the auditory hair cells are located within the organ of Corti on a thin basilar membrane in the cochlea of the inner ear.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004744,mgr,2010-09-29T09:36:28Z,,,,,BrendaTissueOBO,,BTO:0004744,,,,,,,,,,,,,,,,,,,hair cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100372,"[""Olfactory receptor 2t29""]",,"An olfactory receptor 2T29 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH02] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2T29 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH02] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100372,,,,https://pharos.nih.gov/idg/targets/Q8NH02,,,,,,,,,,,,,OR2T29,,,Q8NH02,,,,,,,,Olfactory receptor 2t29,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02402008,"[""Adhesion class gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400001,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02402008,,,,,,,,,,,,,,,,,,,,,,,,,,,,Adhesion class gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001492,"[""limb""]",,1. One of the projecting paired appendages (as wings) of an animal body used especially for movement and grasping but sometimes modified into sensory or sexual organs. 2. A leg or arm of a human being.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,1. One of the projecting paired appendages (as wings) of an animal body used especially for movement and grasping but sometimes modified into sensory or sexual organs. 2. A leg or arm of a human being.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001492,,,,,,,BrendaTissueOBO,Extremitaet,BTO:0001492,,,,,,,,,,,,,,,,,,,limb,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100085,"[""D(1B) dopamine receptor""]",,"A D(1B) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21918] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300037,,,,,,,,"A D(1B) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21918] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100085,,,,https://pharos.nih.gov/idg/targets/P21918,,,,,,,,,,,,,DRD5,DRD1B|DRD1L2,,P21918,,,,,,,,D(1B) dopamine receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217531,"[""THRB gene""]",,"The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_00217460,,,,,,,,"The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217531,,,,,,,,,,,,,,,,7068,THRB,ERBA2|NR1A2|THR1,,,,,,,,,,THRB gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200042,"[""BMP2K gene""]",,"This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400115,,,,,,,,"This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200042,,,,,,,,,,,,,,,,55589,BMP2K,BIKE,,,,,,,,,,BMP2K gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000202,"[""JAK2(JH1domain-catalytic) kinase domain""]",,Janus kinase 2; JAK2; JAK2-catalytic; JTK10,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Janus kinase 2; JAK2; JAK2-catalytic; JTK10,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000202,,,,,,,,,,,,,,,,,,,200207,,,,,,,,,JAK2(JH1domain-catalytic) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100722,"[""Orexin receptor type 2""]",,An orexin receptor type 2 that is encoded in the genome of human. [Reactome:REACT_17071] ,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,An orexin receptor type 2 that is encoded in the genome of human. [Reactome:REACT_17071] ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100722,,,,https://pharos.nih.gov/idg/targets/O43614,,,,,,,,,,,,,HCRTR2,,,O43614,,,,,,,,Orexin receptor type 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200170,"[""GPBAR1 gene""]",,"A G-protein coupled bile acid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDU6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400055,,,,,,,,"A G-protein coupled bile acid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDU6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200170,,,,,,,,,,,,,,,,151306,GPBAR1,TGR5,,,,,,,,,,GPBAR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000371,"[""egg yolk""]",,The yellow spheroidal mass of stored food that forms the inner portion of the egg of a bird or reptile and is surrounded by the white.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The yellow spheroidal mass of stored food that forms the inner portion of the egg of a bird or reptile and is surrounded by the white.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000371,,,,,,,BrendaTissueOBO,yolk,BTO:0000371,,,,,,,,,,,,,,,,,,,egg yolk,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200455,"[""RNASEL gene""]",,"This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400218,,,,,,,,"This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200455,,,,,,,,,,,,,,,,6041,RNASEL,RNS4,,,,,,,,,,RNASEL gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001321,"[""LNCaP cell""]",,"Human prostate carcinoma, established from the left supraclavicular lymph node metastasis from a 50-year-old man with prostate carcinoma in 1977; cells were described to be androgen-sensitive.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001033,,,,,,,,"Human prostate carcinoma, established from the left supraclavicular lymph node metastasis from a 50-year-old man with prostate carcinoma in 1977; cells were described to be androgen-sensitive.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001321,,,,,,,BrendaTissueOBO,LNCAP cell,BTO:0001321,,,,,,,,,,,,,,,,,,,LNCaP cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/UBERON_0001474,"[""bone element""]",bone,Skeletal element that is composed of bone tissue.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000421|http://purl.obolibrary.org/obo/UBERON_0001062,,relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO],,,,,http://linkedlifedata.com/resource/umls/id/C0262950|http://en.wikipedia.org/wiki/Bone|http://www.snomedbrowser.com/Codes/Details/90780006|MA:0001459|MAT:0000299|AAO:0000047|ENVO:00002039|EHDAA2:0003082|BTO:0000140|galen:Bone|OpenCyc:Mx4rvViDlpwpEbGdrcN5Y29ycA|OpenCyc:Mx4rvVkCG5wpEbGdrcN5Y29ycA|UMLS:C0262950|EV:0100140|VSAO:0000057|XAO:0000169|VHOG:0001190|AEO:0000082|EMAPA:32782|FMA:30317|GAID:92|EFO:0000298|TAO:0001514|ZFA:0001514|CALOHA:TS-0088|ncithesaurus:Bone|FMA:5018|MIAA:0000299,Skeletal element that is composed of bone tissue.,,,,,,,,,,"Also called osseous tissue, (Latin: os). Is a type of hard endoskeletal connective tissue found in many vertebrate animals. Bone is the main tissue of body organs that support body structures, protect internal organs, (in conjunction with muscles) facilitate movement; and are involved with cell formation, calcium metabolism, and mineral storage.[AAO]|Skeletal element that is composed of bone tissue.[VSAO]|Portion of tissue which is calcified connective tissue making up the structural elements of the skeletal system.[TAO]",,,,,,,,,,,,,,,,,,,,,,,,,,bone organ|bone element,,uberon,bone,,"The 'new animal phylogeny' reveals that many of the groups known to biomineralize sit among close relatives that do not, and it favours an interpretation of convergent or parallel evolution for biomineralization in animals. (...) Whether this 'biomineralization toolkit'of genes reflects a parallel co-option of a common suite of genes or the inheritance of a skeletogenic gene regulatory network from a biomineralizing common ancestor remains an open debate.[debated][VHOG]",,,,,,,,,,,,,,,,,,,,,,,,UBERON:0001474,,,"Alternate definition: Organ with cavitated organ parts, which primarily consists of compact (cortical) and cancellous bone, which surround bone marrow cavities; together with other bones, cartilages and joints, it constitutes the skeletal system. Examples: femur, sternum, maxilla, vertebra, talus[FMA]",,bone element,,UBERON:0001474,,http://purl.obolibrary.org/obo/uberon.owl,http://purl.obolibrary.org/obo/uberon/core#efo_slim|http://purl.obolibrary.org/obo/uberon/core#organ_slim|http://purl.obolibrary.org/obo/uberon/core#vertebrate_core|http://purl.obolibrary.org/obo/uberon/core#major_organ|http://purl.obolibrary.org/obo/uberon/core#uberon_slim,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300148,"[""DDR family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300148,,,,,,,,,,,,,,,,,,,,,,,,,,,,DDR family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000417,"[""SRPK2 kinase domain""]",,SFRS protein kinase 2; FLJ36101; SFRSK2; SRPK2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,SFRS protein kinase 2; FLJ36101; SFRSK2; SRPK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000417,,,,,,,,,,,,,,,,,,,200418,,,,,,,,,SRPK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200391,"[""PANK1 gene""]",,"This gene encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636). [provided by RefSeq, Apr 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03491028,,,,,,,,"This gene encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636). [provided by RefSeq, Apr 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200391,,,,,,,,,,,,,,,,53354,PANK1,PANK,,,,,,,,,,PANK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004124,"[""HT-1197 cell""]",,"Human urinary bladder carcinoma cell line, established from a 44 years old caucasian male.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000792,,,,,,,,"Human urinary bladder carcinoma cell line, established from a 44 years old caucasian male.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004124,,,,,,,BrendaTissueOBO,HT 1197 cell|HT1197 cell,BTO:0004124,,,,,,,,,,,,,,,,,,,HT-1197 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117469,"[""Testicular receptors""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00102000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117469,,,,,,,,,,,,,,,,,,,,,,,,,,,,Testicular receptors,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200175,"[""HIPK4 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400273,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200175,,,,,,,,,,,,,,,,147746,HIPK4,,,,,,,,,,,HIPK4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001545,"[""acute myeloid leukemia cell""]",,"Adult acute myeloid leukemia (AML) is a disease in which cancer (malignant) cells are found in the blood and bone marrow. More common in adults, the proliferating cells are of the myeloid hematopoietic series and the cells appearing in the blood are primitive granulocytes or monocytes.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001056,,,,,,,,"Adult acute myeloid leukemia (AML) is a disease in which cancer (malignant) cells are found in the blood and bone marrow. More common in adults, the proliferating cells are of the myeloid hematopoietic series and the cells appearing in the blood are primitive granulocytes or monocytes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001545,,,,,,,BrendaTissueOBO,acute myeloblastic leukemia cell|acute myelogenous leukemia cell|AML cell,BTO:0001545,,,,,,,,,,,,,,,,,,,acute myeloid leukemia cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200174,"[""KCNIP4 gene""]",,"This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400357,,,,,,,,"This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200174,,,,,,,,,,,,,,,,80333,KCNIP4,CALP|KCHIP4,,,,,,,,,,KCNIP4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14557,"[""primary pulmonary hypertension""]",,"A chronic pulmonary heart disease characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein, or pulmonary capillaries, among others, has symptoms shortness of breath, dizziness, fainting, leg swelling.",false,,,http://purl.obolibrary.org/obo/DOID_12326,,,,,,,,"A chronic pulmonary heart disease characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein, or pulmonary capillaries, among others, has symptoms shortness of breath, dizziness, fainting, leg swelling.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14557,,,,OMIM:178600|ICD9CM:416.0|OMIM:265400|ORDO:422|SNOMEDCT_US_2016_03_01:155328008|UMLS_CUI:C0152171|SNOMEDCT_US_2016_03_01:26174007|OMIM:615344|SNOMEDCT_US_2016_03_01:266293003|NCI:C97119|OMIM:615342|ICD10CM:I27.0|OMIM:615343,,,disease_ontology,,DOID:14557,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,primary pulmonary hypertension,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14550,"[""root resorption""]",,,false,,,http://purl.obolibrary.org/obo/DOID_13240,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14550,,,,MESH:D012391|UMLS_CUI:C0035851,,,disease_ontology,,DOID:14550,,,,,,,,,,,,,,,,,,,root resorption,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200581,"[""OR4D9 gene""]",,"An olfactory receptor 4D9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4D9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200581,,,,,,,,,,,,,,,,390199,OR4D9,,,,,,,,,,,OR4D9 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000232,"[""Serum amyloid A""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000232,,,,,,,,,,,,,,,,,,,,,,,,,,,,Serum amyloid A,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400475,"[""Nav1.8/SCN10A subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400369,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400475,,,,,,,,,,,,,,,,,,,,,,,,,,,,Nav1.8/SCN10A subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000198,"[""MET736 in MAP3K15""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000198,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET736 in MAP3K15,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200121,"[""GABRP gene""]",,"The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_01400520,,,,,,,,"The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200121,,,,,,,,,,,,,,,,2568,GABRP,,,,,,,,,,,GABRP gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200283,"[""MAP3K1 gene""]",,"The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400186,,,,,,,,"The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200283,,,,,,,,,,,,,,,,4214,MAP3K1,MAPKKK1|MEKK|MEKK1,,,,,,,,,,MAP3K1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200611,"[""OR5A1 gene""]",,"An olfactory receptor 5A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200611,,,,,,,,,,,,,,,,219982,OR5A1,OR5A1P,,,,,,,,,,OR5A1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001122,"[""procyclic form""]",,"African trypanosomes have a digenetic life cycle, which includes growth in the bloodstream and tissue spaces of a mammalian host and several distinct developmental stages, including the procyclic form, in an insect host, Glossina spp., tsetse fly.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000092,,,,,,,,"African trypanosomes have a digenetic life cycle, which includes growth in the bloodstream and tissue spaces of a mammalian host and several distinct developmental stages, including the procyclic form, in an insect host, Glossina spp., tsetse fly.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001122,,,,,,,BrendaTissueOBO,,BTO:0001122,,,,,,,,,,,,,,,,,,,procyclic form,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9351,"[""diabetes mellitus""]",,"A glucose metabolism disease characterized  by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both.",false,,,http://purl.obolibrary.org/obo/DOID_4194,,,,,,,,"A glucose metabolism disease characterized  by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9351,,,,MESH:D003920|NCI:C2985|ICD9CM:250|UMLS_CUI:C0011849|SNOMEDCT_US_2016_03_01:154671004|ICD10CM:E11|SNOMEDCT_US_2016_03_01:191044006|ICD10CM:E08-E13|SNOMEDCT_US_2016_03_01:73211009|SNOMEDCT_US_2016_03_01:267467004,,,disease_ontology,,DOID:9351,,,,,,,,,,,,,,,,,,,diabetes mellitus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9719,"[""proliferative vitreoretinopathy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5679|http://purl.obolibrary.org/obo/DOID_9720,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9719,,,,MESH:D018630|SNOMEDCT_US_2016_03_01:232016005|SNOMEDCT_US_2016_03_01:193364004|UMLS_CUI:C0242852,Retinitis proliferans,,disease_ontology,,DOID:9719,,,,,,,,,,,,,,,,,,,proliferative vitreoretinopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400309,"[""DNAPK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400129,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400309,,,,,,,,,,,,,,,,,,,,,,,,,,,,DNAPK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6725,"[""spinal stenosis""]",,"A bone deterioration disease that has_material_basis_in bony spurs, disc degeneration, or thickened ligaments which results_in narrowing located_in spinal cord.",false,,,http://purl.obolibrary.org/obo/DOID_0080007,,,,,,,,"A bone deterioration disease that has_material_basis_in bony spurs, disc degeneration, or thickened ligaments which results_in narrowing located_in spinal cord.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6725,,,DOID:12235|DOID:10097,MESH:D013130|ICD10CM:M48.06|SNOMEDCT_US_2016_03_01:156646000|UMLS_CUI:C0158288|SNOMEDCT_US_2016_03_01:18347007|ICD10CM:M48.02|SNOMEDCT_US_2016_03_01:83561009|SNOMEDCT_US_2016_03_01:268082002|SNOMEDCT_US_2016_03_01:202791007|UMLS_CUI:C0037944|ICD10CM:M48.0|ICD9CM:724.00|SNOMEDCT_US_2016_03_01:202781001|UMLS_CUI:C0158280|SNOMEDCT_US_2016_03_01:156640006|ICD9CM:723.0|ICD10CM:M48.00|SNOMEDCT_US_2016_03_01:202780000|SNOMEDCT_US_2016_03_01:76107001,Spinal stenosis of lumbar region|cervical spinal stenosis|lumbar spinal stenosis,,disease_ontology,,DOID:6725,,,,,,,,,,,,,,,,,,,spinal stenosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0070004,"[""myeloid neoplasm""]",,"A bone marrow cancer that is formed of any one of the bone marrow cells 
belonging to the granulocytic (neutrophil, eosinophil, basophil), monocytic/macrophage, erythroid, megakaryocytic and mast cell lineages. ",false,,,http://purl.obolibrary.org/obo/DOID_4960,,,,,,,,"A bone marrow cancer that is formed of any one of the bone marrow cells 
belonging to the granulocytic (neutrophil, eosinophil, basophil), monocytic/macrophage, erythroid, megakaryocytic and mast cell lineages. ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0070004,,,,,myeloma,,disease_ontology,,DOID:0070004,,,,,,,,,,,,,,,,,,,myeloid neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0070003,"[""blastoma""]",,A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from precursor cells called blast cells.,false,,,http://purl.obolibrary.org/obo/DOID_0050687,,,,,,,,A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from precursor cells called blast cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0070003,,,,,,,disease_ontology,,DOID:0070003,,,,,,,,,,,,,,,,,,,blastoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000250,"[""chondrosarcoma cell""]",,"Chondrosarcoma is a malignant tumor derived from cartilage cells or their precursors, but lacking direct osteoid formation; it occurs predominantly in the pelvis, femur, and shoulder girdle in middle-aged to older adults. It may be primary, arising from cartilage cells, or secondary to a pre-existing benign lesion.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001207,,,,,,,,"Chondrosarcoma is a malignant tumor derived from cartilage cells or their precursors, but lacking direct osteoid formation; it occurs predominantly in the pelvis, femur, and shoulder girdle in middle-aged to older adults. It may be primary, arising from cartilage cells, or secondary to a pre-existing benign lesion.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000250,,,,,,,BrendaTissueOBO,,BTO:0000250,,,,,,,,,,,,,,,,,,,chondrosarcoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000162,"[""FGFR4 kinase domain""]",,Fibroblast growth factor receptor 4; CD334; FGFR4; JTK2; MGC20292; TKF,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Fibroblast growth factor receptor 4; CD334; FGFR4; JTK2; MGC20292; TKF,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000162,,,,,,,,,,,,,,,,,,,200165,,,,,,,,,FGFR4 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200008,"[""CHRNA3 gene""]",,"This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400492,,,,,,,,"This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200008,,,,,,,,,,,,,,,,1136,CHRNA3,NACHRA3,,,,,,,,,,CHRNA3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003124,"[""microvascular endothelial cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001973,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003124,,,,,,,BrendaTissueOBO,,BTO:0003124,,,,,,,,,,,,,,,,,,,microvascular endothelial cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4988,"[""alcoholic pancreatitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4989,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4988,,,,SNOMEDCT_US_2016_03_01:445507008|MESH:D019512|UMLS_CUI:C0376670,,,disease_ontology,,DOID:4988,,,,,,,,,,,,,,,,,,,alcoholic pancreatitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9976,"[""heroin dependence""]",,An opiate dependence that involves the continued use of heroin despite problems related to use of the substance.,false,,,http://purl.obolibrary.org/obo/DOID_2559,,,,,,,,An opiate dependence that involves the continued use of heroin despite problems related to use of the substance.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9976,,,,NCI:C34694|MESH:D006556|SNOMEDCT_US_2016_03_01:191817000|UMLS_CUI:C0019337|SNOMEDCT_US_2016_03_01:231477003|SNOMEDCT_US_2016_03_01:192220003,,,disease_ontology,,DOID:9976,,,,,,,,,,,,,,,,,,,heroin dependence,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000810,"[""malpighian tubule""]",,Any of a group of long blind vessels opening into the posterior part of the alimentary canal in most insects and some other arthropods and functioning primarily as excretory organs.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001491|http://purl.obolibrary.org/obo/BTO_0000431,,,,,,,,Any of a group of long blind vessels opening into the posterior part of the alimentary canal in most insects and some other arthropods and functioning primarily as excretory organs.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000810,,,,,,,BrendaTissueOBO,tuba Malpighii|malphigian tube,BTO:0000810,,,,,,,,,,,,,,,,,,,malpighian tubule,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200115,"[""GALR1 gene""]",,"A galanin receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47211] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400046,,,,,,,,"A galanin receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47211] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200115,,,,,,,,,,,,,,,,2587,GALR1,GALNR|GALNR1,,,,,,,,,,GALR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100402,"[""Olfactory receptor 51l1""]",,"An olfactory receptor 51L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 51L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100402,,,,https://pharos.nih.gov/idg/targets/Q8NGJ5,,,,,,,,,,,,,OR51L1,,,Q8NGJ5,,,,,,,,Olfactory receptor 51l1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003267,"[""HS-766T cell""]",,Human pancreatic cancer cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000794,,,,,,,,Human pancreatic cancer cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003267,,,,,,,BrendaTissueOBO,Hs766T cell|HS 766T cell|HS766T cell,BTO:0003267,,,,,,,,,,,,,,,,,,,HS-766T cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8643,"[""duodenitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5295,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8643,,,DOID:8983|DOID:8897,UMLS_CUI:C0013298|MESH:D004382|SNOMEDCT_US_2016_03_01:155715004|NCI:C94409|SNOMEDCT_US_2016_03_01:72007001|ICD10CM:K29.8|ICD9CM:535.6,Hemorrhagic duodenitis,,disease_ontology,,DOID:8643,,,,,,,,,,,,,,,,,,,duodenitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300196,"[""MLCK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300196,,,,,,,,,,,,,,,,,,,,,,,,,,,,MLCK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001129,"[""prostate gland""]",,A firm partly muscular partly glandular body that is situated about the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062|http://purl.obolibrary.org/obo/BTO_0000080|http://purl.obolibrary.org/obo/BTO_0003096,,,,,,,,A firm partly muscular partly glandular body that is situated about the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001129,,,,,,,BrendaTissueOBO,prostate,BTO:0001129,,,,,,,,,,,,,,,,,,,prostate gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100003,"[""5-hydroxytryptamine receptor 3C""]",,"A 5-hydroxytryptamine receptor 3C that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WXA8] ",false,,,http://www.drugtargetontology.org/dto/DTO_01309332,,,,,,,,"A 5-hydroxytryptamine receptor 3C that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WXA8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100003,,,,https://pharos.nih.gov/idg/targets/Q8WXA8,,,,,,,,,,,,,HTR3C,,,Q8WXA8,,,,,,,,5-hydroxytryptamine receptor 3C,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100721,"[""Orexin receptor type 1""]",,An orexin receptor type 1 that is encoded in the genome of human. [Reactome:REACT_17344] ,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,An orexin receptor type 1 that is encoded in the genome of human. [Reactome:REACT_17344] ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100721,,,,https://pharos.nih.gov/idg/targets/O43613,,,,,,,,,,,,,HCRTR1,,,O43613,,,,,,,,Orexin receptor type 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003218,"[""U-343 MG-A cell""]",,Human glioma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000711,,,,,,,,Human glioma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003218,,,,,,,BrendaTissueOBO,U-343-MG-A cell|U-343 cell|U343 MG-A cell|U343 cell|U343-MG-A cell,BTO:0003218,,,,,,,,,,,,,,,,,,,U-343 MG-A cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000318,"[""THR279 in BMPR1B""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000318,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR279 in BMPR1B,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200102,"[""FZD10 gene""]",,"A frizzled-10 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9ULW2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400043,,,,,,,,"A frizzled-10 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9ULW2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200102,,,,,,,,,,,,,,,,11211,FZD10,,,,,,,,,,,FZD10 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000243,"[""M3K12 kinase domain""]",,Mitogen-activated protein kinase kinase kinase 12; Dual leucine zipper bearing kinase; DLK; MAP3K12; MEKK12; MUK; ZPK; ZPKP1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase kinase kinase 12; Dual leucine zipper bearing kinase; DLK; MAP3K12; MEKK12; MUK; ZPK; ZPKP1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000243,,,,,,,,,,,,,,,,,,,200114,,,,,,,,,M3K12 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000392,"[""plasma cell""]",,"A terminally differentiated cell of the B lymphocyte lineage that produces antibodies; plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A terminally differentiated cell of the B lymphocyte lineage that produces antibodies; plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000392,,,,,,,BrendaTissueOBO,plasmacyte|plasmocyte,BTO:0000392,,,,,,,,,,,,,,,,,,,plasma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001519,"[""endothelial cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001120,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001519,,,,,,,BrendaTissueOBO,,BTO:0001519,,,,,,,,,,,,,,,,,,,endothelial cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003190,"[""SNU-354 cell""]",,Human hepatocellular carcinoma cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0000578|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human hepatocellular carcinoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003190,,,,,,,BrendaTissueOBO,SNU354 cell,BTO:0003190,,,,,,,,,,,,,,,,,,,SNU-354 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004580,"[""862L cell""]",,Mouse pheochromocytoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000201,,,,,,,,Mouse pheochromocytoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004580,mgr,2010-04-12T10:32:38Z,,,,,BrendaTissueOBO,,BTO:0004580,,,,,,,,,,,,,,,,,,,862L cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200083,"[""CHEK2 gene""]",,"In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400139,,,,,,,,"In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200083,,,,,,,,,,,,,,,,11200,CHEK2,CDS1|CHK2|RAD53,,,,,,,,,,CHEK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000194,"[""INSR kinase domain""]",,Insulin receptor; CD220; HHF5; INSR; IR,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Insulin receptor; CD220; HHF5; INSR; IR,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000194,,,,,,,,,,,,,,,,,,,200197,,,,,,,,,INSR kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100469,"[""Kappa-type opioid receptor""]",,"A kappa-type opioid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41145] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A kappa-type opioid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41145] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100469,,,,https://pharos.nih.gov/idg/targets/P41145,,,,,,,,,,,,,OPRK1,OPRK,,P41145,,,,,,,,Kappa-type opioid receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100075,"[""Cyclin-dependent kinase 9""]",,"cyclin-dependent kinase 9 (CDK9)  with  no mutation  in a nonphosphorylated state|A cyclin-dependent kinase 9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P50750] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300263,,,,,,,,"cyclin-dependent kinase 9 (CDK9)  with  no mutation  in a nonphosphorylated state|A cyclin-dependent kinase 9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P50750] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100075,,,,https://pharos.nih.gov/idg/targets/P50750,,,,,,,,,,,,,CDK9,CDC2L4|TAK,,P50750,,,,,,,,Cyclin-dependent kinase 9,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200450,"[""RIPK1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400124,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200450,,,,,,,,,,,,,,,,8737,RIPK1,RIP|RIP1,,,,,,,,,,RIPK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100013,"[""Uncharacterized aarf domain-containing protein kinase 1""]",,"An uncharacterized aarF domain-containing protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86TW2] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300247,,,,,,,,"An uncharacterized aarF domain-containing protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86TW2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100013,,,,https://pharos.nih.gov/idg/targets/Q86TW2,,,,,,,,,,,,,ADCK1,,,Q86TW2,,,,,,,,Uncharacterized aarf domain-containing protein kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200104,"[""FZD2 gene""]",,"A frizzled-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14332] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400043,,,,,,,,"A frizzled-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14332] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200104,,,,,,,,,,,,,,,,2535,FZD2,,,,,,,,,,,FZD2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400344,"[""Calcium release-activated calcium (crac) channel (crac-c) family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400344,,,,,,,,,,,,,,,,,,,,,,,,,,,,Calcium release-activated calcium (crac) channel (crac-c) family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4194,"[""glucose metabolism disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0050013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4194,,,,MESH:D044882|NCI:C53655|UMLS_CUI:C1257958|SNOMEDCT_US_2016_03_01:126877002,disorder of glucose metabolism (disorder),,disease_ontology,,DOID:4194,,,,,,,,,,,,,,,,,,,glucose metabolism disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11105,"[""fundus albipunctatus""]",,A fundus dystrophy that is characterized by discrete uniform white dots over the entire fundus with greatest density in the midperiphery and no macular involvement.,false,,,http://purl.obolibrary.org/obo/DOID_8501,,,,,,,,A fundus dystrophy that is characterized by discrete uniform white dots over the entire fundus with greatest density in the midperiphery and no macular involvement.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11105,,,,ICD9CM:362.74|SNOMEDCT_US_2016_03_01:68222009|MESH:C562733|ICD10CM:H35.52|OMIM:136880|UMLS_CUI:C0311338,retinitis punctata albescens |Pigmentary retinal dystrophy,,disease_ontology,,DOID:11105,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,fundus albipunctatus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11102,"[""bartonellosis""]",,A primary bacterial infectious disease that is caused by the bacteria of the genus Bartonella.,false,,,http://purl.obolibrary.org/obo/DOID_0050338,,,,,,,,A primary bacterial infectious disease that is caused by the bacteria of the genus Bartonella.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11102,,,,SNOMEDCT_US_2016_03_01:17116008|MESH:D001474|SNOMEDCT_US_2016_03_01:266123003|ICD10CM:A44|UMLS_CUI:C0004771|SNOMEDCT_US_2016_03_01:240454008|SNOMEDCT_US_2016_03_01:240623002|SNOMEDCT_US_2016_03_01:186824002|SNOMEDCT_US_2016_03_01:187340003|NCI:C84586|ICD10CM:A44.9|ICD9CM:088.0,bartonelliasis|Rochalimaea infection (disorder)|Bartonella infectious disease,,disease_ontology,,DOID:11102,http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease|http://purl.obolibrary.org/obo/doid#GOLD,,,,,,,,,,,,,,,,,,bartonellosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11104,"[""spotted fever""]",,"A primary bacterial infectious disease that results_in infection, located_in endothelial cell of artery or located_in endothelial cell of vein, has_material_basis_in Rickettsia, which is transmitted_by ticks and mites. The infection has_symptom fever, has_symptom headache, has_symptom fatigue, has_symptom muscle aches, and has_symptom maculopapular or petechial rash. A distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite.",false,,,http://purl.obolibrary.org/obo/DOID_0050338,,,,,,,,"A primary bacterial infectious disease that results_in infection, located_in endothelial cell of artery or located_in endothelial cell of vein, has_material_basis_in Rickettsia, which is transmitted_by ticks and mites. The infection has_symptom fever, has_symptom headache, has_symptom fatigue, has_symptom muscle aches, and has_symptom maculopapular or petechial rash. A distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11104,,,,SNOMEDCT_US_2016_03_01:186773004|ICD10CM:A77.9|UMLS_CUI:C0038041|SNOMEDCT_US_2016_03_01:187385002|SNOMEDCT_US_2016_03_01:186771002|ICD9CM:082.0|ICD10CM:A77,Spotted fever group rickettsial disease (disorder),,disease_ontology,,DOID:11104,http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease,,,,,,,,,,,,,,,,,,spotted fever,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200050,"[""CASR gene""]",,"An extracellular calcium-sensing receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41180] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400029,,,,,,,,"An extracellular calcium-sensing receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41180] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200050,,,,,,,,,,,,,,,,846,CASR,GPRC2A|PCAR1,,,,,,,,,,CASR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400051,"[""LU7TM family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400051,,,,,,,,,,,,,,,,,,,,,,,,,,,,LU7TM family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_28834,"[""deoxycholic acid""]","[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@]([H])([C@H](C)CCC(O)=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2|C24H40O4|KXGVEGMKQFWNSR-LLQZFEROSA-N|7alpha-deoxycholic acid|Desoxycholsaeure|(3alpha,5beta,12alpha)-3,12-dihydroxycholan-24-oic acid|desoxycholic acid|392.293|392.57200|InChI=1S/C24H40O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-/m1/s1|(3ALPHA,5ALPHA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID|3alpha,12alpha-Dihydroxy-5beta-cholanic acid|0",A bile acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 12 respectively.,false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,CAS:83-44-3|KEGG:C04483|DrugBank:DB03619|KNApSAcK:C00030117|LINCS:LSM-5529|PDBeChem:DXC|Gmelin:670078|Beilstein:3219882|Drug_Central:4988|LIPID_MAPS_instance:LMST04010040,A bile acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 12 respectively.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:23616|CHEBI:1687|CHEBI:42317,,"Deoxycholic acid|3alpha,12alpha-dihydroxy-5beta-cholan-24-oic acid",,chebi_ontology,"[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@]([H])([C@H](C)CCC(O)=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2|C24H40O4|KXGVEGMKQFWNSR-LLQZFEROSA-N|7alpha-deoxycholic acid|Desoxycholsaeure|(3alpha,5beta,12alpha)-3,12-dihydroxycholan-24-oic acid|desoxycholic acid|392.293|392.57200|InChI=1S/C24H40O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-/m1/s1|(3ALPHA,5ALPHA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID|3alpha,12alpha-Dihydroxy-5beta-cholanic acid|0",,,CHEBI:28834,,,,,,,,,,,,,,,,,,,,,,,CHEBI:28834,,,,,deoxycholic acid,,CHEBI:28834,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117520,"[""Nuclear receptor subfamily 4 group a member 1""]",,"A nuclear receptor subfamily 4 group A member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P22736] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117475,,,,,,,,"A nuclear receptor subfamily 4 group A member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P22736] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117520,,,,https://pharos.nih.gov/idg/targets/P22736,,,,,,,,,,,,,NR4A1,HMR,,P22736,,,,,,,,Nuclear receptor subfamily 4 group a member 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000203,"[""respiratory system""]",,A system of organs subserving the function of respiration and in air-breathing vertebrates consisting typically of the lungs and their nervous and circulatory supply and the channels by which these are continuous with the outer air.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A system of organs subserving the function of respiration and in air-breathing vertebrates consisting typically of the lungs and their nervous and circulatory supply and the channels by which these are continuous with the outer air.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000203,,,,,,,BrendaTissueOBO,respiratory tract|apparatus respiratorius |Atmungssystem,BTO:0000203,,,,,,,,,,,,,,,,,,,respiratory system,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100205,"[""Potassium voltage-gated channel subfamily H member 1""]",,"A voltage-gated potassium channel KCNH1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O95259] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300553,,,,,,,,"A voltage-gated potassium channel KCNH1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O95259] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100205,,,,https://pharos.nih.gov/idg/targets/O95259,,,,,,,,,,,,,KCNH1,EAG|EAG1,,O95259,,,,,,,,Potassium voltage-gated channel subfamily H member 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300056,"[""Estrogen (G protein-coupled) receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300056,,,,,,,,,,,,,,,,,,,,,,,,,,,,Estrogen (G protein-coupled) receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391034,"[""HUNK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300116,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391034,,,,,,,,,,,,,,,,,,,,,,,,,,,,HUNK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400139,"[""RAD53 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400139,,,,,,,,,,,,,,,,,,,,,,,,,,,,RAD53 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1542,"[""head and neck carcinoma""]",,"A head and neck cancer that has_material_basis_in epithelial cells and is located_in the upper aerodigestive tract, including the lip, oral cavity (mouth), nasal cavity, paranasal sinuses, pharynx, and larynx.",false,,,http://purl.obolibrary.org/obo/DOID_11934,,,,,,,,"A head and neck cancer that has_material_basis_in epithelial cells and is located_in the upper aerodigestive tract, including the lip, oral cavity (mouth), nasal cavity, paranasal sinuses, pharynx, and larynx.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1542,,,,UMLS_CUI:C1334927|NCI:C6077,carcinoma of the neck,,disease_ontology,carcinoma of neck,DOID:1542,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,head and neck carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10825,"[""essential hypertension""]",,A hypertension with no known cause. It is the most common type of hypertension.,false,,,http://purl.obolibrary.org/obo/DOID_10763,,,,,,,,A hypertension with no known cause. It is the most common type of hypertension.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10825,,,,ICD9CM:401|SNOMEDCT_US_2016_03_01:194760004|ICD10CM:I10|MESH:C562386|OMIM:610261|OMIM:604329|SNOMEDCT_US_2016_03_01:155296003|SNOMEDCT_US_2016_03_01:266228004|OMIM:610948|OMIM:145500|NCI:C3478|SNOMEDCT_US_2016_03_01:59621000|ORDO:243761|ICD9CM:401.9|SNOMEDCT_US_2016_03_01:194757006|OMIM:607329|OMIM:611014|OMIM:603918|OMIM:610262|UMLS_CUI:C0085580|OMIM:608742,idiopathic hypertension|primary hypertension,,disease_ontology,,DOID:10825,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,essential hypertension,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100001,"[""5-hydroxytryptamine receptor 1a""]",,"A 5-hydroxytryptamine receptor 1A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08908] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302001,,,,,,,,"A 5-hydroxytryptamine receptor 1A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08908] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100001,,,,https://pharos.nih.gov/idg/targets/P08908,,,,,,,,,,,,,HTR1A,ADRB2RL1|ADRBRL1,,P08908,,,,,,,,5-hydroxytryptamine receptor 1a,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300551,"[""Kv6.3/KCNG3 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300447,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300551,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv6.3/KCNG3 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300109,"[""AGC group""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300102,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300109,,,,,,,,,,,,,,,,,,,,,,,,,,,,AGC group,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000190,"[""IGF1R kinase domain""]",,Insulin-like growth factor 1 receptor; CD221; IGF1R; IGFIR; IGFR; JTK13; MGC142170; MGC142172; MGC18216,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Insulin-like growth factor 1 receptor; CD221; IGF1R; IGFIR; IGFR; JTK13; MGC142170; MGC142172; MGC18216,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000190,,,,,,,,,,,,,,,,,,,200193,,,,,,,,,IGF1R kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200079,"[""CXCR5 gene""]",,"A C-X-C chemokine receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32302] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400097,,,,,,,,"A C-X-C chemokine receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32302] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200079,,,,,,,,,,,,,,,,643,CXCR5,BLR1|MDR15,,,,,,,,,,CXCR5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000039,"[""LEU118 in KCC4""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000039,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU118 in KCC4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100024,"[""ITD in FLT3(ITD)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100024,,,,,,,,,,,,,,,,,,,,,,,,,,,,ITD in FLT3(ITD),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100290,"[""Olfactory receptor 10A4""]",,"An olfactory receptor 10A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H209] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H209] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100290,,,,https://pharos.nih.gov/idg/targets/Q9H209,,,,,,,,,,,,,OR10A4,OR10A4P,,Q9H209,,,,,,,,Olfactory receptor 10A4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200595,"[""PANK4 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200595,,,,,,,,,,,,,,,,,,,,,,,,,,,,PANK4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000077,"[""CDK4-cyclinD1 kinase domain""]",,Cyclin-dependent kinase 4; cell division protein kinase 4,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Cyclin-dependent kinase 4; cell division protein kinase 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000077,,,,,,,,,,,,,,,,,,,200077,,,,,,,,,CDK4-cyclinD1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01390003,"[""Chloride channel""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01390003,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chloride channel,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100334,"[""Transient receptor potential cation channel subfamily v member 2""]",,"A transient receptor potential cation channel TRPV2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9Y5S1] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300591,,,,,,,,"A transient receptor potential cation channel TRPV2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9Y5S1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100334,,,,https://pharos.nih.gov/idg/targets/Q9Y5S1,,,,,,,,,,,,,TRPV2,VRL,,Q9Y5S1,,,,,,,,Transient receptor potential cation channel subfamily v member 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200081,"[""CERK gene""]",,"CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400323,,,,,,,,"CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200081,,,,,,,,,,,,,,,,64781,CERK,KIAA1646,,,,,,,,,,CERK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200481,"[""OR1D2 gene""]",,"An olfactory receptor 1D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P34982] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P34982] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200481,,,,,,,,,,,,,,,,4991,OR1D2,OLFR1,,,,,,,,,,OR1D2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300491,"[""Alpha-2/CHRNA2 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300491,,,,,,,,,,,,,,,,,,,,,,,,,,,,Alpha-2/CHRNA2 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000227,"[""MET95 in CAMK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000227,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET95 in CAMK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003038,"[""HEC-1-B cell""]",,This is a substrain of HEC-1-A.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,This is a substrain of HEC-1-A.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003038,Marion,2010-01-29T10:24:37Z,,,,,BrendaTissueOBO,HEC1B cell|HEC-1B cell,BTO:0003038,,,,,,,,,,,,,,,,,,,HEC-1-B cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002353,"[""digitum minimus pedis""]",,"The fifth, and smallest, digit of the foot.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002348,,,,,,,,"The fifth, and smallest, digit of the foot.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002353,,,,,,,BrendaTissueOBO,digitus quintus (V) pedis|little toe,BTO:0002353,,,,,,,,,,,,,,,,,,,digitum minimus pedis,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003684,"[""habenula""]",,"A component of the epithalamus, being the small eminence on the dorsomedial surface of the thalamus, just in front of the dorsal commissure on the lateral edge of the habenular trigone.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A component of the epithalamus, being the small eminence on the dorsomedial surface of the thalamus, just in front of the dorsal commissure on the lateral edge of the habenular trigone.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003684,,,,,,,BrendaTissueOBO,pineal peduncle,BTO:0003684,,,,,,,,,,,,,,,,,,,habenula,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217537,"[""PPARG gene""]",,"This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_00217462,,,,,,,,"This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217537,,,,,,,,,,,,,,,,5468,PPARG,NR1C3,,,,,,,,,,PPARG gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200659,"[""OR6F1 gene""]",,"An olfactory receptor 6F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200659,,,,,,,,,,,,,,,,343169,OR6F1,,,,,,,,,,,OR6F1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005788,"[""SH-EP1 cell""]",,"Human neuroblastoma cell line, established from brain bone marrow tissue from a 4 years old caucasian white with neuroblastoma.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000932,,,,,,,,"Human neuroblastoma cell line, established from brain bone marrow tissue from a 4 years old caucasian white with neuroblastoma.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005788,Marion,2015-10-01T09:14:25Z,,,,,BrendaTissueOBO,,BTO:0005788,,,,,,,,,,,,,,,,,,,SH-EP1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2997,"[""Sertoli-Leydig cell tumor""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4757,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2997,,,,SNOMEDCT_US_2016_03_01:34110004|MESH:D018310|UMLS_CUI:C0206723,,,disease_ontology,,DOID:2997,,,,,,,,,,,,,,,,,,,Sertoli-Leydig cell tumor,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000961,"[""olfactory bulb""]",,A bulbous anterior projection of the olfactory lobe that is the place of termination of the olfactory nerves and is especially well developed in lower vertebrates (as fishes).,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A bulbous anterior projection of the olfactory lobe that is the place of termination of the olfactory nerves and is especially well developed in lower vertebrates (as fishes).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000961,,,,,,,BrendaTissueOBO,bulbus olfactorius,BTO:0000961,,,,,,,,,,,,,,,,,,,olfactory bulb,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217468,"[""Retinoid x receptors gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00200002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217468,,,,,,,,,,,,,,,,,,,,,,,,,,,,Retinoid x receptors gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300215,"[""SLOB family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300215,,,,,,,,,,,,,,,,,,,,,,,,,,,,SLOB family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002061,"[""bronchogenic carcinoma cell""]",,"Any of a large group of carcinomas of the lung, so called because they arise from the epithelium of the bronchial tree. Four primary subtypes are distinguished: adenocarcinoma of the lung, large cell carcinoma, small cell carcinoma, and squamous cell carcinoma.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000551,,,,,,,,"Any of a large group of carcinomas of the lung, so called because they arise from the epithelium of the bronchial tree. Four primary subtypes are distinguished: adenocarcinoma of the lung, large cell carcinoma, small cell carcinoma, and squamous cell carcinoma.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002061,,,,,,,BrendaTissueOBO,,BTO:0002061,,,,,,,,,,,,,,,,,,,bronchogenic carcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100249,"[""Mucolipin-1""]",,"A mucolipin-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZU1] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300574,,,,,,,,"A mucolipin-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZU1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100249,,,,https://pharos.nih.gov/idg/targets/Q9GZU1,,,,,,,,,,,,,MCOLN1,ML4,,Q9GZU1,,,,,,,,Mucolipin-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200613,"[""OR5B2 gene""]",,"An olfactory receptor 5B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R09] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R09] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200613,,,,,,,,,,,,,,,,390190,OR5B2,,,,,,,,,,,OR5B2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100382,"[""Phosphatidylinositol 3-kinase regulatory subunit alpha""]",,A phosphatidylinositol 3-kinase regulatory subunit alpha that is encoded in the genome of human. ,false,,,http://www.drugtargetontology.org/dto/DTO_03391031,,,,,,,,A phosphatidylinositol 3-kinase regulatory subunit alpha that is encoded in the genome of human. ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100382,,,,https://pharos.nih.gov/idg/targets/P27986,,,,,,,,,,,,,PIK3R1,GRB1,,P27986,,,,,,,,Phosphatidylinositol 3-kinase regulatory subunit alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100569,"[""Serine/threonine-protein kinase wnk3""]",,"serine/threonine-protein kinase wnk3 (WNK3)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase WNK3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BYP7] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300244,,,,,,,,"serine/threonine-protein kinase wnk3 (WNK3)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase WNK3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BYP7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100569,,,,https://pharos.nih.gov/idg/targets/Q9BYP7,,,,,,,,,,,,,WNK3,KIAA1566|PRKWNK3,,Q9BYP7,,,,,,,,Serine/threonine-protein kinase wnk3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200118,"[""GABRG1 gene""]",,"The protein encoded by this gene belongs to the ligand-gated ionic channel family. It is an integral membrane protein and plays an important role in inhibiting neurotransmission by binding to the benzodiazepine receptor and opening an integral chloride channel. This gene is clustered with three other family members on chromosome 4. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400517,,,,,,,,"The protein encoded by this gene belongs to the ligand-gated ionic channel family. It is an integral membrane protein and plays an important role in inhibiting neurotransmission by binding to the benzodiazepine receptor and opening an integral chloride channel. This gene is clustered with three other family members on chromosome 4. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200118,,,,,,,,,,,,,,,,2565,GABRG1,,,,,,,,,,,GABRG1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000372,"[""THR670 in KIT(L576P)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000372,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR670 in KIT(L576P),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000000,"[""tissues, cell types and enzyme sources""]",,"A structured controlled vocabulary for the source of an enzyme. It comprises terms of tissues, cell lines, cell types and cell cultures from uni- and multicellular organisms.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A structured controlled vocabulary for the source of an enzyme. It comprises terms of tissues, cell lines, cell types and cell cultures from uni- and multicellular organisms.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000000,,,,,,,BrendaTissueOBO,,BTO:0000000,,,,,,,,,,,,,,,,,,,"tissues, cell types and enzyme sources",,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000104,"[""lymphoma cell line""]",,Lymphoma means any neoplastic disorder of the lymphoid tissue.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Lymphoma means any neoplastic disorder of the lymphoid tissue.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000104,,,,,,,BrendaTissueOBO,lymphadenoma cell line,BTO:0000104,,,,,,,,,,,,,,,,,,,lymphoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200114,"[""DYRK1B gene""]",,"This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400266,,,,,,,,"This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200114,,,,,,,,,,,,,,,,9149,DYRK1B,MIRK,,,,,,,,,,DYRK1B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001801,"[""skeletal muscle cancer cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001801,,,,,,,BrendaTissueOBO,,BTO:0001801,,,,,,,,,,,,,,,,,,,skeletal muscle cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100488,"[""Putative olfactory receptor 1f2""]",,"An olfactory receptor 1F2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R84] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1F2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R84] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100488,,,,https://pharos.nih.gov/idg/targets/Q96R84,,,,,,,,,,,,,OR1F2P,OR1F2,,Q96R84,,,,,,,,Putative olfactory receptor 1f2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000013,"[""GLN600 in JAK3(Kin.Dom.2)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30011,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000013,,,,,,,,,,,,,,,,,,,,,,,,,,,,GLN600 in JAK3(Kin.Dom.2),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300244,"[""WNK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300244,,,,,,,,,,,,,,,,,,,,,,,,,,,,WNK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400237,"[""TRBL family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400237,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRBL family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/UBERON_0001255,"[""urinary bladder""]",urocyst|vesica,distensible musculomembranous organ situated in the anterior part of the pelvic cavity in which urine collects before excretion[MP].,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062|http://purl.obolibrary.org/obo/BTO_0000123,,,,,,,http://en.wikipedia.org/wiki/Urinary_bladder|http://linkedlifedata.com/resource/umls/id/C0005682|http://www.snomedbrowser.com/Codes/Details/302512001|EFO:0000290|MIAA:0000122|EMAPA:18321|MA:0000380|MAT:0000122|BTO:0001418|CALOHA:TS-1090|XAO:0000154|EHDAA2:0000174|GAID:0000004|EV:0100098|EHDAA:9328|VHOG:0000740|OpenCyc:Mx4rvVjMmZwpEbGdrcN5Y29ycA|AAO:0000623|ncithesaurus:Bladder|UMLS:C0005682|galen:UrinaryBladder|FMA:15900|MESH:A05.810.161,distensible musculomembranous organ situated in the anterior part of the pelvic cavity in which urine collects before excretion[MP].,,http://upload.wikimedia.org/wikipedia/commons/3/30/Urinary_system.svg|http://upload.wikimedia.org/wikipedia/commons/thumb/3/30/Urinary_system.svg/200px-Urinary_system.svg.png,,,,,,,,"A saccular organ in which urine accumulates before discharge from the body. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]|Anatomical structure which consists of a membranous sac used to temporarily store urine until it is excreted from the body.[AAO]",,,,,,,,,,,,,,,,,,,,,,,,,,vesica urinaria|bladder,,uberon,urocyst|vesica,vesical,"In tetrapods, the urinary bladder arises as an outpocketing of the cloaca. (...) The tetrapod urinary bladder appears first among amphibians and is present in Sphenodon, turtles, most lizards, ostriches among birds, and all mammals.[well established][VHOG]",,,,,,,,,,,,,,,,,,,,,,,,UBERON:0001255,,,,,urinary bladder,,UBERON:0001255,,http://purl.obolibrary.org/obo/uberon.owl,http://purl.obolibrary.org/obo/uberon/core#efo_slim|http://purl.obolibrary.org/obo/uberon/core#organ_slim|http://purl.obolibrary.org/obo/uberon/core#major_organ|http://purl.obolibrary.org/obo/uberon/core#uberon_slim,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200140,"[""ERBB3 gene""]",,"This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400152,,,,,,,,"This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200140,,,,,,,,,,,,,,,,2065,ERBB3,HER3,,,,,,,,,,ERBB3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400171,"[""CAMK1 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400171,,,,,,,,,,,,,,,,,,,,,,,,,,,,CAMK1 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004368,"[""vestibular nucleus""]",,Any of four nuclei in the medulla oblongata on each side of the floor of the fourth ventricle of the brain in which fibers of the vestibular nerve terminate.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Any of four nuclei in the medulla oblongata on each side of the floor of the fourth ventricle of the brain in which fibers of the vestibular nerve terminate.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004368,,,,,,,BrendaTissueOBO,,BTO:0004368,,,,,,,,,,,,,,,,,,,vestibular nucleus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000220,"[""CXCL7""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000220,,,,,,,,,,,,,,,,,,,,,,,,,,,,CXCL7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000304,"[""MYLK4 kinase domain""]",,"Myosin light chain kinase family, member 4; MYLK4; SgK085",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Myosin light chain kinase family, member 4; MYLK4; SgK085",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000304,,,,,,,,,,,,,,,,,,,200281,,,,,,,,,MYLK4 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000011,"[""ABL1(F317L)-phosphorylated kinase domain""]",,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",false,,,http://www.drugtargetontology.org/dto/DTO_61000009,,,,,,,,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000011,,,,,,,,,,,,,,,,,,,200010,,,,,,,,,ABL1(F317L)-phosphorylated kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000234,"[""MET98 in ANKK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000234,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET98 in ANKK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200408,"[""PIK3R4 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400206,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200408,,,,,,,,,,,,,,,,30849,PIK3R4,,,,,,,,,,,PIK3R4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100015,"[""Atypical kinase adck3, mitochondrial""]",,"Atypical kinase ADCK3, mitochondrial (ADCK3)  with  no mutation  in a nonphosphorylated state|A chaperone activity of bc1 complex-like, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NI60] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300249,,,,,,,,"Atypical kinase ADCK3, mitochondrial (ADCK3)  with  no mutation  in a nonphosphorylated state|A chaperone activity of bc1 complex-like, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NI60] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100015,,,,https://pharos.nih.gov/idg/targets/Q8NI60,,,,,,,,,,,,,ADCK3,CABC1,,Q8NI60,,,,,,,,"Atypical kinase adck3, mitochondrial",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000075,"[""CDK2 kinase domain""]",,Cyclin-dependent kinase 2; p33 protein kinase,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Cyclin-dependent kinase 2; p33 protein kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000075,,,,,,,,,,,,,,,,,,,200075,,,,,,,,,CDK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200206,"[""PRKACG gene""]",,"Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400169,,,,,,,,"Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200206,,,,,,,,,,,,,,,,5568,PRKACG,,,,,,,,,,,PRKACG gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14737,"[""craniofrontonasal syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050735,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14737,,,,MESH:C536456|OMIM:304110|UMLS_CUI:C0220767,craniofrontonasal dysplasia,,disease_ontology,,DOID:14737,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,craniofrontonasal syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300221,"[""RYK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300221,,,,,,,,,,,,,,,,,,,,,,,,,,,,RYK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001086,"[""embryonic stem cell""]",,Totipotent cell cultured from early embryo. Have the advantage that following modification in vitrothey can be used to produce chimeric embryos and thus transgenic animals.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Totipotent cell cultured from early embryo. Have the advantage that following modification in vitrothey can be used to produce chimeric embryos and thus transgenic animals.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001086,,,,,,,BrendaTissueOBO,ES cell,BTO:0001086,,,,,,,,,,,,,,,,,,,embryonic stem cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100045,"[""Q834 in FLT3(R834Q)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100045,,,,,,,,,,,,,,,,,,,,,,,,,,,,Q834 in FLT3(R834Q),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200566,"[""WEE2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400212,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200566,,,,,,,,,,,,,,,,494551,WEE2,WEE1B,,,,,,,,,,WEE2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9835,"[""refractive error""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5614,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9835,,,,SNOMEDCT_US_2016_03_01:39021009|NCI:C87145|MESH:D012030|SNOMEDCT_US_2016_03_01:267723000|SNOMEDCT_US_2016_03_01:21324001|SNOMEDCT_US_2016_03_01:314027003|UMLS_CUI:C0034951|ICD10CM:H52.7|EFO:0003908,,,disease_ontology,,DOID:9835,,,,,,,,,,,,,,,,,,,refractive error,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3675,"[""childhood kidney neoplasm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_263,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3675,,,,UMLS_CUI:C1333003|NCI:C6563,pediatric renal tumor,,disease_ontology,,DOID:3675,,,,,,,,,,,,,,,,,,,childhood kidney neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200048,"[""CACNB1 gene""]",,"The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400334,,,,,,,,"The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200048,,,,,,,,,,,,,,,,782,CACNB1,CACNLB1,,,,,,,,,,CACNB1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100667,"[""Olfactory receptor 6p1""]",,"An olfactory receptor 6P1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6P1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100667,,,,https://pharos.nih.gov/idg/targets/Q8NGX9,,,,,,,,,,,,,OR6P1,,,Q8NGX9,,,,,,,,Olfactory receptor 6p1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000237,"[""MET99 in MST4""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000237,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET99 in MST4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003019,"[""NCI-H345 cell""]",,Small cell lung cancer cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002206,,,,,,,,Small cell lung cancer cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003019,,,,,,,BrendaTissueOBO,H345 cell|H-345 cell,BTO:0003019,,,,,,,,,,,,,,,,,,,NCI-H345 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100562,"[""Olfactory receptor 3a2""]",,"An olfactory receptor 3A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47893] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 3A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47893] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100562,,,,https://pharos.nih.gov/idg/targets/P47893,,,,,,,,,,,,,OR3A2,OLFRA04,,P47893,,,,,,,,Olfactory receptor 3a2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000359,"[""PIP5K1C kinase domain""]",,"Phosphatidylinositol-4-phosphate 5-kinase, type I, gamma; KIAA0589; LCCS3; PIP5K1C; PIP5Kgamma; PIP5K-GAMMA; PIPKIg_v4",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Phosphatidylinositol-4-phosphate 5-kinase, type I, gamma; KIAA0589; LCCS3; PIP5K1C; PIP5Kgamma; PIP5K-GAMMA; PIPKIg_v4",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000359,,,,,,,,,,,,,,,,,,,200341,,,,,,,,,PIP5K1C kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000131,"[""EGFR(T790M) kinase domain""]",,"Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000131,,,,,,,,,,,,,,,,,,,200133,,,,,,,,,EGFR(T790M) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005729,"[""chemoreceptor cell""]",,"A sensory nerve cell or sense organ, as of smell or taste, that responds to chemical stimuli.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001037,,,,,,,,"A sensory nerve cell or sense organ, as of smell or taste, that responds to chemical stimuli.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005729,Marion,2015-04-27T09:44:25Z,,,,,BrendaTissueOBO,,BTO:0005729,,,,,,,,,,,,,,,,,,,chemoreceptor cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001757,"[""medulloblastoma cell""]",,"A cell of a malignant, highly radiosensitive cerebellar tumor composed of undifferentiated neuroglial cells.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000526,,,,,,,,"A cell of a malignant, highly radiosensitive cerebellar tumor composed of undifferentiated neuroglial cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001757,,,,,,,BrendaTissueOBO,,BTO:0001757,,,,,,,,,,,,,,,,,,,medulloblastoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003716,"[""ScN2a cell""]",,Scrapie-infected mouse neuroblastoma N2a cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Scrapie-infected mouse neuroblastoma N2a cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003716,,,,,,,BrendaTissueOBO,,BTO:0003716,,,,,,,,,,,,,,,,,,,ScN2a cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000364,"[""PKN1 kinase domain""]",,Protein kinase N1; DBK; MGC46204; PAK1; PAK-1; PKN; PKN1; PKN1/PRK1; PKN-ALPHA; PRK1; PRKCL1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Protein kinase N1; DBK; MGC46204; PAK1; PAK-1; PKN; PKN1; PKN1/PRK1; PKN-ALPHA; PRK1; PRKCL1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000364,,,,,,,,,,,,,,,,,,,200347,,,,,,,,,PKN1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100157,"[""1-phosphatidylinositol 3-phosphate 5-kinase""]",,"A 1-phosphatidylinositol 3-phosphate 5-kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y2I7] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300323,,,,,,,,"A 1-phosphatidylinositol 3-phosphate 5-kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y2I7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100157,,,,https://pharos.nih.gov/idg/targets/Q9Y2I7,,,,,,,,,,,,,PIKFYVE,KIAA0981|PIP5K3,,Q9Y2I7,,,,,,,,1-phosphatidylinositol 3-phosphate 5-kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400258,"[""CDK1 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400136,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400258,,,,,,,,,,,,,,,,,,,,,,,,,,,,CDK1 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2559,"[""opiate dependence""]",,A drug dependence that involves the continued use of opiate drugs despite despite problems related to use of the substance.,false,,,http://purl.obolibrary.org/obo/DOID_9974,,,,,,,,A drug dependence that involves the continued use of opiate drugs despite despite problems related to use of the substance.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2559,,,,UMLS_CUI:C0524662|ICD9CM:304.00|SNOMEDCT_US_2016_03_01:191817000|ICD9CM:304.0|MESH:D009293|SNOMEDCT_US_2016_03_01:191818005|ICD10CM:F11.2|SNOMEDCT_US_2016_03_01:75544000|SNOMEDCT_US_2016_03_01:192220003,Opioid type dependence,,disease_ontology,,DOID:2559,,,,,,,,,,,,,,,,,,,opiate dependence,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000464,"[""flagellate""]",,A flagellate protozoan or alga.,false,,,http://purl.obolibrary.org/obo/BTO_0002503|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000720,,,,,,,,A flagellate protozoan or alga.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000464,,,,,,,BrendaTissueOBO,,BTO:0000464,,,,,,,,,,,,,,,,,,,flagellate,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100041,"[""P396 in ABL1(H396P)-phosphorylated""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100041,,,,,,,,,,,,,,,,,,,,,,,,,,,,P396 in ABL1(H396P)-phosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400425,"[""KCNJ14 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400425,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ14 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100240,"[""Serine/threonine-protein kinase d3""]",,"serine/threonine-protein kinase d3 (KPCD3)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase D3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O94806] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300176,,,,,,,,"serine/threonine-protein kinase d3 (KPCD3)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase D3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O94806] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100240,,,,https://pharos.nih.gov/idg/targets/O94806,,,,,,,,,,,,,PRKD3,EPK2|PRKCN,,O94806,,,,,,,,Serine/threonine-protein kinase d3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200586,"[""OR4F3; OR4F16; OR4F29 gene""]",,An olfactory receptor 4F3/4F16/4F29 that is encoded in the genome of human. ,false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,An olfactory receptor 4F3/4F16/4F29 that is encoded in the genome of human. ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200586,,,,,,,,,,,,,,,,26683|729759|81399,OR4F3,OR4F16|OR4F29,,,,,,,,,,OR4F3; OR4F16; OR4F29 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100576,"[""Olfactory receptor 4c16""]",,"An olfactory receptor 4C16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4C16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100576,,,,https://pharos.nih.gov/idg/targets/Q8NGL9,,,,,,,,,,,,,OR4C16,,,Q8NGL9,,,,,,,,Olfactory receptor 4c16,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100621,"[""Olfactory receptor 5d16""]",,"An olfactory receptor 5D16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5D16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100621,,,,https://pharos.nih.gov/idg/targets/Q8NGK9,,,,,,,,,,,,,OR5D16,,,Q8NGK9,,,,,,,,Olfactory receptor 5d16,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100185,"[""Insulin receptor-related protein""]",,"insulin receptor-related protein (INSRR)  with  no mutation  in a nonphosphorylated state|An insulin receptor-related protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:P14616] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300163,,,,,,,,"insulin receptor-related protein (INSRR)  with  no mutation  in a nonphosphorylated state|An insulin receptor-related protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:P14616] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100185,,,,https://pharos.nih.gov/idg/targets/P14616,,,,,,,,,,,,,INSRR,IRR,,P14616,,,,,,,,Insulin receptor-related protein,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004798,"[""accessory sex gland""]",,"Male accessory glands in humans are the seminal vesicles, prostate gland, and the bulbourethral glands. In insects, male accessory glands produce products that mix with the sperm to protect and preserve them.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000080,,,,,,,,"Male accessory glands in humans are the seminal vesicles, prostate gland, and the bulbourethral glands. In insects, male accessory glands produce products that mix with the sperm to protect and preserve them.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004798,mgr,2010-10-05T09:32:58Z,,,,,BrendaTissueOBO,male accessory gland,BTO:0004798,,,,,,,,,,,,,,,,,,,accessory sex gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100007,"[""5-hydroxytryptamine receptor 2B""]",,"A 5-hydroxytryptamine receptor 2B that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41595] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302002,,,,,,,,"A 5-hydroxytryptamine receptor 2B that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41595] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100007,,,,https://pharos.nih.gov/idg/targets/P41595,,,,,,,,,,,,,HTR2B,,,P41595,,,,,,,,5-hydroxytryptamine receptor 2B,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100112,"[""Dual serine/threonine and tyrosine protein kinase""]",,"A dual serine/threonine and tyrosine protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6XUX3] |dual serine/threonine and tyrosine protein kinase (RIPK5)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300149,,,,,,,,"A dual serine/threonine and tyrosine protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6XUX3] |dual serine/threonine and tyrosine protein kinase (RIPK5)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100112,,,,https://pharos.nih.gov/idg/targets/Q6XUX3,,,,,,,,,,,,,DSTYK,KIAA0472|RIP5|RIPK5|SGK496,,Q6XUX3,,,,,,,,Dual serine/threonine and tyrosine protein kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100453,"[""Olfactory receptor 5as1""]",,"An olfactory receptor 5AS1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N127] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5AS1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N127] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100453,,,,https://pharos.nih.gov/idg/targets/Q8N127,,,,,,,,,,,,,OR5AS1,,,Q8N127,,,,,,,,Olfactory receptor 5as1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100806,"[""Trace amine-associated receptor 8""]",,"A trace amine-associated receptor 8 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q969N4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A trace amine-associated receptor 8 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q969N4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100806,,,,https://pharos.nih.gov/idg/targets/Q969N4,,,,,,,,,,,,,TAAR8,GPR102|TA5|TAR5|TRAR5,,Q969N4,,,,,,,,Trace amine-associated receptor 8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6603,"[""Kummell's disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1123,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6603,,,,SNOMEDCT_US_2016_03_01:65753008|SNOMEDCT_US_2016_03_01:111232005|SNOMEDCT_US_2016_03_01:156628006|UMLS_CUI:C0152088|SNOMEDCT_US_2016_03_01:268075001|SNOMEDCT_US_2016_03_01:240218006|ICD9CM:721.7|ICD10CM:M48.3|SNOMEDCT_US_2016_03_01:202682000,Traumatic spondylopathy|Kummell's spondylitis|Kummell disease,,disease_ontology,,DOID:6603,,,,,,,,,,,,,,,,,,,Kummell's disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400430,"[""KCNJ3 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400430,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ3 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491003,"[""Type III PI4K subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491009,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491003,,,,,,,,,,,,,,,,,,,,,,,,,,,,Type III PI4K subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001422,"[""uterine endometrium""]",,The mucous membrane lining the uterus.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000886,,,,,,,,The mucous membrane lining the uterus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001422,,,,,,,BrendaTissueOBO,uterine mucous membrane|endometrium,BTO:0001422,,,,,,,,,,,,,,,,,,,uterine endometrium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001572,"[""articular cartilage""]",,"A thin layer of cartilage, usually hyaline, on the articular surface of bones in synovial joints.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000206,,,,,,,,"A thin layer of cartilage, usually hyaline, on the articular surface of bones in synovial joints.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001572,,,,,,,BrendaTissueOBO,hyaline cartilage,BTO:0001572,,,,,,,,,,,,,,,,,,,articular cartilage,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100173,"[""G-protein coupled receptor family c group 5 member c""]",,"A G-protein coupled receptor family C group 5 member C that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NQ84] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300004,,,,,,,,"A G-protein coupled receptor family C group 5 member C that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NQ84] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100173,,,,https://pharos.nih.gov/idg/targets/Q9NQ84,,,,,,,,,,,,,GPRC5C,RAIG3,,Q9NQ84,,,,,,,,G-protein coupled receptor family c group 5 member c,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03390989,"[""Eukaryotic two domain clade \\\""E\\\"" sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03390989,,,,,,,,,,,,,,,,,,,,,,,,,,,,"Eukaryotic two domain clade ""E"" sub-subfamily",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13374,"[""fibrodysplasia ossificans progressiva""]",,".A connective tissue disease that is characterized by progressive ossification of skeletal muscle, fascia, tendons, and ligaments and has_material_basis_in heterozygous mutation in the ACVR1 gene.",false,,,http://purl.obolibrary.org/obo/DOID_65,,,,,,,,".A connective tissue disease that is characterized by progressive ossification of skeletal muscle, fascia, tendons, and ligaments and has_material_basis_in heterozygous mutation in the ACVR1 gene.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13374,,,,ICD9CM:728.11|SNOMEDCT_US_2016_03_01:205527009|ICD10CM:M61.10|SNOMEDCT_US_2016_03_01:240121004|ICD10CM:M61.1|SNOMEDCT_US_2016_03_01:82725007|OMIM:135100|MESH:D009221|NCI:C3040|UMLS_CUI:C0016037,Stone Man Syndrome|progressive ossifying myositis|progressive myositis ossificans|myositis ossificans progressiva,,disease_ontology,,DOID:13374,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,fibrodysplasia ossificans progressiva,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13378,"[""Kawasaki disease""]",,"A lymphadenitis characterized by swelling of cervical lymph nodes in infants and young children and inflammation of medium-sized blood vessels located_in body, has_symptom fever, has_symptom congestion of ocular conjunctivae, has_symptom reddening of lips, has_symptom reddening of oral cavity, has_symptom protuberance of tongue papillae and has_symptom edema of extremities.",false,,,http://purl.obolibrary.org/obo/DOID_1602,,,,,,,,"A lymphadenitis characterized by swelling of cervical lymph nodes in infants and young children and inflammation of medium-sized blood vessels located_in body, has_symptom fever, has_symptom congestion of ocular conjunctivae, has_symptom reddening of lips, has_symptom reddening of oral cavity, has_symptom protuberance of tongue papillae and has_symptom edema of extremities.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13378,,,,EFO:0004246|OMIM:611775|ICD10CM:M30.3|SNOMEDCT_US_2016_03_01:195348009|MESH:D009080|SNOMEDCT_US_2016_03_01:155444003|SNOMEDCT_US_2016_03_01:75053002|SNOMEDCT_US_2016_03_01:195349001|UMLS_CUI:C0026691|ICD9CM:446.1|NCI:C34825,Kawasaki's disease|mucocutaneous lymph node syndrome|acute febrile mucocutaneous lymph node syndrome [MCLS]|acute febrile MCLS|MLNS,,disease_ontology,,DOID:13378,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Kawasaki disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13372,"[""alpha 1-antitrypsin deficiency""]",,"A plasma protein metabolism disease that has_material_basis_in defective production of the protease inhibitor alpha 1-antitrypsin (A1AT), leading to decreased A1AT activity in the blood and lungs, and deposition of excessive abnormal A1AT protein in liver cells.",false,,,http://purl.obolibrary.org/obo/DOID_2345,,,,,,,,"A plasma protein metabolism disease that has_material_basis_in defective production of the protease inhibitor alpha 1-antitrypsin (A1AT), leading to decreased A1AT activity in the blood and lungs, and deposition of excessive abnormal A1AT protein in liver cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13372,,,,ICD9CM:273.4|OMIM:613490|SNOMEDCT_US_2016_03_01:30188007|UMLS_CUI:C0221757|MESH:D019896|SNOMEDCT_US_2016_03_01:154771007|NCI:C84397|ICD10CM:E88.01,AAT deficiency,,disease_ontology,,DOID:13372,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,alpha 1-antitrypsin deficiency,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8927,"[""learning disability""]",,"A specific developmental disorder that involves difficulty in scholastic skills such as reading, writing, spelling, reasoning, recalling and/or organizing information resulting from the brain's inability to receive and process information.",false,,,http://purl.obolibrary.org/obo/DOID_0060038,,,,,,,,"A specific developmental disorder that involves difficulty in scholastic skills such as reading, writing, spelling, reasoning, recalling and/or organizing information resulting from the brain's inability to receive and process information.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8927,,,DOID:2847,NCI:C89334|SNOMEDCT_US_2016_03_01:192531005|SNOMEDCT_US_2016_03_01:247576004|MESH:D007859|SNOMEDCT_US_2016_03_01:367332004|SNOMEDCT_US_2016_03_01:389991004|SNOMEDCT_US_2016_03_01:154973004|SNOMEDCT_US_2016_03_01:154974005|UMLS_CUI:C0023186|SNOMEDCT_US_2016_03_01:1855002|UMLS_CUI:C0751265|ICD10CM:F81.9,learning disorder|Academic skill disorder,,disease_ontology,,DOID:8927,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,learning disability,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100209,"[""G-protein coupled receptor 78""]",,"A G-protein coupled receptor 78 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P69] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 78 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P69] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100209,,,,https://pharos.nih.gov/idg/targets/Q96P69,,,,,,,,,,,,,GPR78,,,Q96P69,,,,,,,,G-protein coupled receptor 78,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200580,"[""OR4D6 gene""]",,"An olfactory receptor 4D6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4D6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200580,,,,,,,,,,,,,,,,219983,OR4D6,,,,,,,,,,,OR4D6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000997,"[""parathyroid gland""]",,Any of usually four small endocrine glands that are adjacent to or embedded in the thyroid gland and produce parathyroid hormone.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001488,,,,,,,,Any of usually four small endocrine glands that are adjacent to or embedded in the thyroid gland and produce parathyroid hormone.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000997,,,,,,,BrendaTissueOBO,parathyroid,BTO:0000997,,,,,,,,,,,,,,,,,,,parathyroid gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9828,"[""neonatal abstinence syndrome""]",,A withdrawal disorder that is characterized by a group of problems that occur in a newborn who was exposed to addictive illegal or prescription drugs while in the mother's womb or postnatally following the discontinuance of drug treatment.,false,,,http://purl.obolibrary.org/obo/DOID_0060001,,,,,,,,A withdrawal disorder that is characterized by a group of problems that occur in a newborn who was exposed to addictive illegal or prescription drugs while in the mother's womb or postnatally following the discontinuance of drug treatment.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9828,,,DOID:6679,NCI:C87101|ICD10CM:P96.1|MESH:D009357|SNOMEDCT_US_2016_03_01:414819007|UMLS_CUI:C1332133|NCI:C35808|ICD9CM:779.5|SNOMEDCT_US_2016_03_01:61628006|UMLS_CUI:C0027609,Drug withdrawal syndrome in newborn,,disease_ontology,,DOID:9828,,,,,,,,,,,,,,,,,,,neonatal abstinence syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100279,"[""Mitogen-activated protein kinase kinase kinase 13""]",,"mitogen-activated protein kinase kinase kinase 13 (M3K13)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase kinase kinase 13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43283] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300285,,,,,,,,"mitogen-activated protein kinase kinase kinase 13 (M3K13)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase kinase kinase 13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43283] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100279,,,,https://pharos.nih.gov/idg/targets/O43283,,,,,,,,,,,,,MAP3K13,LZK,,O43283,,,,,,,,Mitogen-activated protein kinase kinase kinase 13,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14472,"[""hantavirus pulmonary syndrome""]",,"A viral infectious disease that results_in infection located_in lung, has_material_basis_in Sin Nombre virus, transmitted_by deer mouse (Myodes glareolus), has_material_basis_in Black Creek Canal virus, transmitted_by cotton rat (Sigmodon hispidus), has_material_basis_in Bayou virus, transmitted_by marsh rice rat (Oryzomys palustris), has_material_basis_in Laguna Negra virus, transmitted_by small vesper mouse (Calomys laucha), or has_material_basis_in Andes virus, transmitted_by rice rat (Oligoryzomys longicaudatus). The infection has_symptom fever, has_symptom muscle pain, has_symptom headache, has_symptom cough, has_symptom vomiting, has_symptom chills which rapidly progress to bilateral interstitial pulmonary infiltrates occurrence, pulmonary edema and hypoxia often resulting in death from shock or cardiac complications.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in infection located_in lung, has_material_basis_in Sin Nombre virus, transmitted_by deer mouse (Myodes glareolus), has_material_basis_in Black Creek Canal virus, transmitted_by cotton rat (Sigmodon hispidus), has_material_basis_in Bayou virus, transmitted_by marsh rice rat (Oryzomys palustris), has_material_basis_in Laguna Negra virus, transmitted_by small vesper mouse (Calomys laucha), or has_material_basis_in Andes virus, transmitted_by rice rat (Oligoryzomys longicaudatus). The infection has_symptom fever, has_symptom muscle pain, has_symptom headache, has_symptom cough, has_symptom vomiting, has_symptom chills which rapidly progress to bilateral interstitial pulmonary infiltrates occurrence, pulmonary edema and hypoxia often resulting in death from shock or cardiac complications.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14472,,,,MESH:D018804|UMLS_CUI:C0243025|NCI:C84747|SNOMEDCT_US_2016_03_01:120639003,,,disease_ontology,,DOID:14472,http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,hantavirus pulmonary syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100678,"[""Olfactory receptor 7c1""]",,"An olfactory receptor 7C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76099] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 7C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76099] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100678,,,,https://pharos.nih.gov/idg/targets/O76099,,,,,,,,,,,,,OR7C1,OR7C4,,O76099,,,,,,,,Olfactory receptor 7c1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200271,"[""PANX1 gene""]",,"The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400365,,,,,,,,"The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200271,,,,,,,,,,,,,,,,24145,PANX1,MRS1,,,,,,,,,,PANX1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002330,"[""lamina propria""]",,A highly vascular layer of connective tissue under the basement membrane lining a layer of epithelium.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000421,,,,,,,,A highly vascular layer of connective tissue under the basement membrane lining a layer of epithelium.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002330,,,,,,,BrendaTissueOBO,tunica propria,BTO:0002330,,,,,,,,,,,,,,,,,,,lamina propria,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1289,"[""neurodegenerative disease""]",,A central nervous system disease that results_in the progressive deterioration of function or structure of neurons.,false,,,http://purl.obolibrary.org/obo/DOID_331,,,,,,,,A central nervous system disease that results_in the progressive deterioration of function or structure of neurons.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1289,,,DOID:4874,UMLS_CUI:C0524851|UMLS_CUI:C1285162|MESH:D019636|NCI:C27090|ICD10CM:G31.9|SNOMEDCT_US_2016_03_01:362975008,Neurodegenerative disease|degenerative disease,,disease_ontology,,DOID:1289,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,neurodegenerative disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12897,"[""submandibular gland disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_10854,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12897,,,,MESH:D013364|UMLS_CUI:C0038557,,,disease_ontology,,DOID:12897,,,,,,,,,,,,,,,,,,,submandibular gland disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200323,"[""MAPK11 gene""]",,"This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400294,,,,,,,,"This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200323,,,,,,,,,,,,,,,,5600,MAPK11,PRKM11|SAPK2|SAPK2B,,,,,,,,,,MAPK11 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100232,"[""Calcium/calmodulin-dependent protein kinase kinase 1""]",,"A calcium/calmodulin-dependent protein kinase kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N5S9] |calcium/calmodulin-dependent protein kinase kinase 1 (KKCC1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300275,,,,,,,,"A calcium/calmodulin-dependent protein kinase kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N5S9] |calcium/calmodulin-dependent protein kinase kinase 1 (KKCC1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100232,,,,https://pharos.nih.gov/idg/targets/Q8N5S9,,,,,,,,,,,,,CAMKK1,CAMKKA,,Q8N5S9,,,,,,,,Calcium/calmodulin-dependent protein kinase kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200247,"[""PRKCZ gene""]",,"Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400279,,,,,,,,"Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200247,,,,,,,,,,,,,,,,5590,PRKCZ,PKC2,,,,,,,,,,PRKCZ gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004038,"[""colonic neoplasm cell""]",,An abnormal growth of tissue in animals or plants. Neoplasms can be benign or malignant.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,An abnormal growth of tissue in animals or plants. Neoplasms can be benign or malignant.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004038,XPMUser,2013-03-15T12:16:35Z,,,,,BrendaTissueOBO,colonic tumor cell,BTO:0004038,,,,,,,,,,,,,,,,,,,colonic neoplasm cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200374,"[""NUAK1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400301,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200374,,,,,,,,,,,,,,,,9891,NUAK1,ARK5|KIAA0537|OMPHK1,,,,,,,,,,NUAK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100290,"[""Sodium channel subunit beta-1""]",,"A sodium channel subunit beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q07699] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300464,,,,,,,,"A sodium channel subunit beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q07699] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100290,,,,https://pharos.nih.gov/idg/targets/Q07699,,,,,,,,,,,,,SCN1B,,,Q07699,,,,,,,,Sodium channel subunit beta-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100006,"[""Neuronal acetylcholine receptor subunit alpha-10""]",,"A neuronal acetylcholine receptor subunit alpha-10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZZ6] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300490,,,,,,,,"A neuronal acetylcholine receptor subunit alpha-10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZZ6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100006,,,,https://pharos.nih.gov/idg/targets/Q9GZZ6,,,,,,,,,,,,,CHRNA10,NACHRA10,,Q9GZZ6,,,,,,,,Neuronal acetylcholine receptor subunit alpha-10,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300329,"[""Calcium-dependent chloride channel (ca-clc) family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300329,,,,,,,,,,,,,,,,,,,,,,,,,,,,Calcium-dependent chloride channel (ca-clc) family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100332,"[""Transient receptor potential cation channel subfamily M member 8""]",,"A transient receptor potential cation channel TRPM8 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q7Z2W7] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300589,,,,,,,,"A transient receptor potential cation channel TRPM8 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q7Z2W7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100332,,,,https://pharos.nih.gov/idg/targets/Q7Z2W7,,,,,,,,,,,,,TRPM8,LTRPC6|TRPP8,,Q7Z2W7,,,,,,,,Transient receptor potential cation channel subfamily M member 8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000089,"[""CIT kinase domain""]",,"Citron (rho-interacting, serine/threonine kinase 21); CIT; CRIK; KIAA0949; STK21",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Citron (rho-interacting, serine/threonine kinase 21); CIT; CRIK; KIAA0949; STK21",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000089,,,,,,,,,,,,,,,,,,,200089,,,,,,,,,CIT kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100172,"[""Homeodomain-interacting protein kinase 1""]",,"A homeodomain-interacting protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86Z02] |homeodomain-interacting protein kinase 1 (HIPK1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300273,,,,,,,,"A homeodomain-interacting protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86Z02] |homeodomain-interacting protein kinase 1 (HIPK1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100172,,,,https://pharos.nih.gov/idg/targets/Q86Z02,,,,,,,,,,,,,HIPK1,KIAA0630|MYAK|NBAK2,,Q86Z02,,,,,,,,Homeodomain-interacting protein kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400325,"[""Carbohydrate kinase gene""]",,A carbohydrate kinase is a kinase enzyme that catalyzes the phosphorylation of a carbohydrate substrate.,false,,,http://www.drugtargetontology.org/dto/DTO_03400103,,,,,,,,A carbohydrate kinase is a kinase enzyme that catalyzes the phosphorylation of a carbohydrate substrate.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400325,,,,,,,,,,,,,,,,,,,,,,,,,,,,Carbohydrate kinase gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004044,"[""amacrine cell""]",,"An unipolar nerve cell found in the retina, in the olfactory bulb, and in close connection with the Purkinje cells of the cerebellum.",false,,,http://purl.obolibrary.org/obo/BTO_0000938|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"An unipolar nerve cell found in the retina, in the olfactory bulb, and in close connection with the Purkinje cells of the cerebellum.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004044,,,,,,,BrendaTissueOBO,,BTO:0004044,,,,,,,,,,,,,,,,,,,amacrine cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000118,"[""DYRK1B kinase domain""]",,Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B; DYRK1B; MIRK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B; DYRK1B; MIRK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000118,,,,,,,,,,,,,,,,,,,200120,,,,,,,,,DYRK1B kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000065,"[""amnion""]",,"A thin, tough, membranous sac that encloses the embryo or fetus of a mammal, bird, or reptile. It is filled with a serous fluid in which the embryo is suspended.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000473,,,,,,,,"A thin, tough, membranous sac that encloses the embryo or fetus of a mammal, bird, or reptile. It is filled with a serous fluid in which the embryo is suspended.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000065,,,,,,,BrendaTissueOBO,,BTO:0000065,,,,,,,,,,,,,,,,,,,amnion,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000119,"[""Agouti-related protein""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000119,,,,,,,,,,,,,,,,,,,,,,,,,,,,Agouti-related protein,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100350,"[""Myosin light chain kinase, smooth muscle""]",,"myosin light chain kinase, smooth muscle (MYLK)  with  no mutation  in a nonphosphorylated state|A myosin light chain kinase, smooth muscle that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15746] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300196,,,,,,,,"myosin light chain kinase, smooth muscle (MYLK)  with  no mutation  in a nonphosphorylated state|A myosin light chain kinase, smooth muscle that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15746] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100350,,,,https://pharos.nih.gov/idg/targets/Q15746,,,,,,,,,,,,,MYLK,MLCK|MLCK1|MYLK1,,Q15746,,,,,,,,"Myosin light chain kinase, smooth muscle",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100675,"[""Olfactory receptor 7A5""]",,"An olfactory receptor 7A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15622] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 7A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15622] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100675,,,,https://pharos.nih.gov/idg/targets/Q15622,,,,,,,,,,,,,OR7A5,,,Q15622,,,,,,,,Olfactory receptor 7A5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200439,"[""OR56A3 gene""]",,"An olfactory receptor 56A3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH54] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 56A3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH54] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200439,,,,,,,,,,,,,,,,390083,OR56A3,OR56A3P|OR56A6,,,,,,,,,,OR56A3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001952,"[""HPB-ALL cell""]",,Human T cell leukemia cell line; established from the peripheral blood of a 14-year-old Japanese boy with ALL and thymoma at diagnosis in 1973.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000741,,,,,,,,Human T cell leukemia cell line; established from the peripheral blood of a 14-year-old Japanese boy with ALL and thymoma at diagnosis in 1973.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001952,,,,,,,BrendaTissueOBO,,BTO:0001952,,,,,,,,,,,,,,,,,,,HPB-ALL cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001615,"[""colorectal cancer cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001615,,,,,,,BrendaTissueOBO,CRC cell|colorectal carcinoma cell,BTO:0001615,,,,,,,,,,,,,,,,,,,colorectal cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200237,"[""PRKCB gene""]",,"Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400276,,,,,,,,"Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200237,,,,,,,,,,,,,,,,5579,PRKCB,PKCB|PRKCB1,,,,,,,,,,PRKCB gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200025,"[""ALPK3 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400123,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200025,,,,,,,,,,,,,,,,57538,ALPK3,KIAA1330|MAK,,,,,,,,,,ALPK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000227,"[""KPCD3 kinase domain""]",,Protein kinase D3; EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN; PRKD3,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Protein kinase D3; EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN; PRKD3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000227,,,,,,,,,,,,,,,,,,,200361,,,,,,,,,KPCD3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300542,"[""Kv3.2/KCNC2 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300443,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300542,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv3.2/KCNC2 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200149,"[""GPR144 gene""]",,"A G-protein coupled receptor 144 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z7M1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,"A G-protein coupled receptor 144 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z7M1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200149,,,,,,,,,,,,,,,,347088,GPR144,PGR24,,,,,,,,,,GPR144 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2512,"[""nevoid basal cell carcinoma syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2512,,,,SNOMEDCT_US_2016_03_01:188145001|SNOMEDCT_US_2016_03_01:254704004|NCI:C2892|UMLS_CUI:C0004779|OMIM:109400|SNOMEDCT_US_2016_03_01:69408002|MESH:D001478,Gorlin syndrome|basal cell nevus syndrome,,disease_ontology,,DOID:2512,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,nevoid basal cell carcinoma syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300578,"[""TRPC3 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300482,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300578,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPC3 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001036,"[""retinal cone""]",,"The other light-sensitive cell type of the retina, that, unlike retinal rods, is differentially sensitive to particular wavelengths of light, and is important for colour vision. There are three types of cones, each type sensitive to red, green or blue. Present in large numbers in the fovea.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001060,,,,,,,,"The other light-sensitive cell type of the retina, that, unlike retinal rods, is differentially sensitive to particular wavelengths of light, and is important for colour vision. There are three types of cones, each type sensitive to red, green or blue. Present in large numbers in the fovea.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001036,,,,,,,BrendaTissueOBO,cone cell,BTO:0001036,,,,,,,,,,,,,,,,,,,retinal cone,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100280,"[""Neuropeptide S receptor""]",,"A neuropeptide S receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q6W5P4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300070,,,,,,,,"A neuropeptide S receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q6W5P4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100280,,,,https://pharos.nih.gov/idg/targets/Q6W5P4,,,,,,,,,,,,,NPSR1,GPR154|GPRA|PGR14,,Q6W5P4,,,,,,,,Neuropeptide S receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100321,"[""Short transient receptor potential channel 3""]",,"A transient receptor potential cation channel TRPC3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13507] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300578,,,,,,,,"A transient receptor potential cation channel TRPC3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13507] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100321,,,,https://pharos.nih.gov/idg/targets/Q13507,,,,,,,,,,,,,TRPC3,TRP3,,Q13507,,,,,,,,Short transient receptor potential channel 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002362,"[""pancreatic duct""]",,"The main excretory duct of the pancreas, which usually unites with the common bile duct before entering the duodenum at the major duodenal papilla.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The main excretory duct of the pancreas, which usually unites with the common bile duct before entering the duodenum at the major duodenal papilla.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002362,,,,,,,BrendaTissueOBO,canal of Wirsung|hepaticopancreatic duct|duct of Wirsung,BTO:0002362,,,,,,,,,,,,,,,,,,,pancreatic duct,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200476,"[""RRH gene""]",,"A visual pigment-like receptor peropsin that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14718] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A visual pigment-like receptor peropsin that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14718] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200476,,,,,,,,,,,,,,,,10692,RRH,,,,,,,,,,,RRH gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100308,"[""Olfactory receptor 10h2""]",,"An olfactory receptor 10H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60403] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60403] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100308,,,,https://pharos.nih.gov/idg/targets/O60403,,,,,,,,,,,,,OR10H2,,,O60403,,,,,,,,Olfactory receptor 10h2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300309,"[""DNAPK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300129,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300309,,,,,,,,,,,,,,,,,,,,,,,,,,,,DNAPK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8445,"[""intestinal volvulus""]",,,false,,,http://purl.obolibrary.org/obo/DOID_8437,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8445,,,,SNOMEDCT_US_2016_03_01:9707006|UMLS_CUI:C0042961|NCI:C98963|SNOMEDCT_US_2016_03_01:90738007|ICD10CM:K56.2|ICD9CM:560.2|SNOMEDCT_US_2016_03_01:197057008|SNOMEDCT_US_2016_03_01:155774005|SNOMEDCT_US_2016_03_01:197061002|MESH:D045822,"Twist of intestine, bowel, or colon|intestinal volvulus|Volvulus",,disease_ontology,,DOID:8445,,,,,,,,,,,,,,,,,,,intestinal volvulus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_16978,"[""leukotriene C4""]","
(5S,6R,7E,9E,11Z,14Z)-6-{[(2R)-2-[(4S)-4-amino-4-carboxybutanamido]-2-[(carboxymethyl)carbamoyl]ethyl]sulfanyl}-5-hydroxyicosa-7,9,11,14-tetraenoic acid
|LTC|
L-gamma-Glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraenyl]-L-cysteinyl-glycine
|
5S-Hydroxy,6R-(S-glutathionyl),7E,9E,11Z,14Z-eicosatetraenoate
|GWNVDXQDILPJIG-NXOLIXFESA-N|
CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)[C@@H](O)CCCC(O)=O
|
[R-[R*,S*-(E,E,Z,Z)]]-N-[S-[1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl]-N-L-gamma-glutamyl-L-cysteinyl]-Glycine 5S,6R-LTC4
|
(R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-N-L-gamma-glutamyl-L-cysteinyl)-Glycine
|Leukotriene C1|C30H47N3O9S|LTC (sub 4)|Leucotriene C4|
5S-hydroxy,6R-(S-glutathionyl),7E,9E,11Z,14Z-eicosatetraenoic acid
|
(R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-Carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-N-L-gamma-glutamyl-L-cysteinyl)glycine
|
InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1
|5S,6R-Ltc|5S,6R-Ltc(sub 4)|Leukotriene C|LTC4","
A leukotriene that contains cysteine in their structure.
",false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,CiteXplore:8434868|CiteXplore:1652771|CiteXplore:6440558|HMDB:HMDB01198|MetaCyc:LEUKOTRIENE-C4|CiteXplore:9051719|CiteXplore:3421265|CiteXplore:9384524|CiteXplore:20671299|CiteXplore:8939179|CiteXplore:2558123|CiteXplore:2633615|CiteXplore:10064732|CiteXplore:8608646|Wikipedia:Leukotriene_C4|Wikipedia:Leukotriene C4|CiteXplore:12895596|CiteXplore:2007712|CiteXplore:2512259|KEGG COMPOUND:72025-60-6|CiteXplore:8415814|ChemIDplus:72025-60-6|CiteXplore:15537867|CiteXplore:9642160|CiteXplore:15243994|CiteXplore:24244016|Reaxys:4732117|CiteXplore:2509375|LIPID MAPS:LMFA03020003|CiteXplore:9042024|CiteXplore:3153930|CiteXplore:7714683|CiteXplore:8938552|KEGG COMPOUND:C02166|CiteXplore:3418380|CiteXplore:2411760,"
A leukotriene that contains cysteine in their structure.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:14504|CHEBI:6422|CHEBI:25025,,"
L-gamma-glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl]-L-cysteinylglycine
|Leukotriene C4",,chebi_ontology,"
(5S,6R,7E,9E,11Z,14Z)-6-{[(2R)-2-[(4S)-4-amino-4-carboxybutanamido]-2-[(carboxymethyl)carbamoyl]ethyl]sulfanyl}-5-hydroxyicosa-7,9,11,14-tetraenoic acid
|LTC|
L-gamma-Glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraenyl]-L-cysteinyl-glycine
|
5S-Hydroxy,6R-(S-glutathionyl),7E,9E,11Z,14Z-eicosatetraenoate
|GWNVDXQDILPJIG-NXOLIXFESA-N|
CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)[C@@H](O)CCCC(O)=O
|
[R-[R*,S*-(E,E,Z,Z)]]-N-[S-[1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl]-N-L-gamma-glutamyl-L-cysteinyl]-Glycine 5S,6R-LTC4
|
(R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-N-L-gamma-glutamyl-L-cysteinyl)-Glycine
|Leukotriene C1|C30H47N3O9S|LTC (sub 4)|Leucotriene C4|
5S-hydroxy,6R-(S-glutathionyl),7E,9E,11Z,14Z-eicosatetraenoic acid
|
(R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-Carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-N-L-gamma-glutamyl-L-cysteinyl)glycine
|
InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1
|5S,6R-Ltc|5S,6R-Ltc(sub 4)|Leukotriene C|LTC4",,,CHEBI:16978,,,,,,,,,,,,,,,,,,,,,,,CHEBI:16978,,,,,leukotriene C4|LTC4,,CHEBI:16978,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11277,"[""Plummer's disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_7998,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11277,,,,ICD9CM:242.3|NCI:C35171|ICD10CM:E05.2|SNOMEDCT_US_2016_03_01:190250001|UMLS_CUI:C0342127|SNOMEDCT_US_2016_03_01:57777000|SNOMEDCT_US_2016_03_01:190254005,Toxic nodular Goiter|Toxic nodular goiter unspecified (disorder)|Toxic nodular goiter NOS (disorder)|Plummer disease|Toxic nodular goiter (disorder),,disease_ontology,,DOID:11277,,,,,,,,,,,,,,,,,,,Plummer's disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400045,"[""GABA-B receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400004,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400045,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABA-B receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000025,"[""LEU100 in MYO3A""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000025,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU100 in MYO3A,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200632,"[""OR5K3 gene""]",,"An olfactory receptor 5K3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NET4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5K3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NET4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200632,,,,,,,,,,,,,,,,403277,OR5K3,,,,,,,,,,,OR5K3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100224,"[""Metabotropic glutamate receptor 7""]",,"A metabotropic glutamate receptor 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14831] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300059,,,,,,,,"A metabotropic glutamate receptor 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14831] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100224,,,,https://pharos.nih.gov/idg/targets/Q14831,,,,,,,,,,,,,GRM7,GPRC1G|MGLUR7,,Q14831,,,,,,,,Metabotropic glutamate receptor 7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100417,"[""Olfactory receptor 52E4""]",,"An olfactory receptor 52E4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 52E4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100417,,,,https://pharos.nih.gov/idg/targets/Q8NGH9,,,,,,,,,,,,,OR52E4,,,Q8NGH9,,,,,,,,Olfactory receptor 52E4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4109,"[""tick infestation""]",,"A parasitic ectoparasitic infectious disease that involves parasitic infestation of blood feeding ticks of the families Ixodidae and Argasidae on animals and humans. Ticks are vectors of a number diseases, including Lyme disease, Q fever, Colorado tick fever, tularemia, tick-borne relapsing fever, babesiosis, ehrlichiosis and tick-borne meningoencephalitis, as well as anaplasmosis in cattle and canine jaundice.",false,,,http://purl.obolibrary.org/obo/DOID_4110,,,,,,,,"A parasitic ectoparasitic infectious disease that involves parasitic infestation of blood feeding ticks of the families Ixodidae and Argasidae on animals and humans. Ticks are vectors of a number diseases, including Lyme disease, Q fever, Colorado tick fever, tularemia, tick-borne relapsing fever, babesiosis, ehrlichiosis and tick-borne meningoencephalitis, as well as anaplasmosis in cattle and canine jaundice.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4109,,,,UMLS_CUI:C0040196|MESH:D013984,,,disease_ontology,,DOID:4109,,,,,,,,,,,,,,,,,,,tick infestation,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100001,"[""5-hydroxytryptamine receptor 3A""]",,"A 5-hydroxytryptamine receptor 3A that is encoded in the genome of human. [PRO:DNx, UniProtKB:P46098] ",false,,,http://www.drugtargetontology.org/dto/DTO_01309332,,,,,,,,"A 5-hydroxytryptamine receptor 3A that is encoded in the genome of human. [PRO:DNx, UniProtKB:P46098] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100001,,,,https://pharos.nih.gov/idg/targets/P46098,,,,,,,,,,,,,HTR3A,5HT3R|HTR3,,P46098,,,,,,,,5-hydroxytryptamine receptor 3A,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_28918,"[""(R)-adrenaline""]","(R)-(-)-Epinephrine|Vasoconstrictine|Suprarenin|L-Adrenaline|Exadrin|
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
|Supracapsulin|CNC[C@H](O)c1ccc(O)c(O)c1|Chelafrin|Epipen|
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
|Epinephran|levoepinephrine|Renoform|Renostyptin|
4-[(1R)-1-hydroxy-2-methylamino-ethyl]benzene-1,2-diol
|(R)-(-)-Epirenamine|Levorenen|Adrin|L-Epinephrine|UCTWMZQNUQWSLP-VIFPVBQESA-N|
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
|Adrenalin|Renaleptine|Levoreninum|Glauposine|Supranephrane|epinefrina|(R)-Epinephrine|Lyodrin|
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
|Scurenaline|Epipen JR|(-)-adrenaline|Isoptoepinal|L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol|Suprarenaline|Surrenine|Renaglandin|Renalina|Eppy|Bronkaid Mist|(R)-(-)-Adnephrine|Hemisine|
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
|Styptirenal|L-Epirenamine|Levorenine|C9H13NO3|epinephrine|Nieraline|Paranephrin|Epinefrina|adrenaline|Nephridine|Mucidrina|Primatene|Epiglaufrin|(R)-(-)-Adrenaline|Renostypticin|(-)-(R)-epinephrine|Ana-Kit|R-(-)-Epinephrine|(-)-Epinephrine|Adnephrine|Hemostatin|Epirenan|L-Methylaminoethanolcatechol|(R)-(-)-adrenaline|Hypernephrin|Sus-phrine|Simplene|Adrenine|Levorenin|Methylarterenol|Hemostasin|Epifrin|Vasotonin|epinephrinum|
(-)-3,4-dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
|
InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1
|
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
|Bosmin|Epinephrin|4-[(1R)-1-hydroxy-2-methylamino-ethyl]pyrocatechol|Adrenal|Takamina|Primatene Mist|
4-[(1R)-1-hydroxy-2-methylaminoethyl]benzene-1,2-diol
","
The R-enantiomer of adrenaline. It is a hormone secreted by the adrenal glands resulting in the 'fight-or-flight' response.
",false,,,http://purl.obolibrary.org/obo/CHEBI_32952,,,,,,,CiteXplore:16777916|Reaxys:2368277|CiteXplore:22115931|CiteXplore:23164182|DrugBank:DB00668|CiteXplore:22895980|CiteXplore:22425731|KEGG DRUG:D00095|CiteXplore:9384611|CiteXplore:7704967|CiteXplore:23130169|Beilstein:2368277|CiteXplore:22826982|NIST Chemistry WebBook:51-43-4|CiteXplore:22898765|KEGG COMPOUND:51-43-4|CiteXplore:16705573|ChemIDplus:51-43-4|CiteXplore:18325983|CiteXplore:12649306|CiteXplore:10349032|CiteXplore:7769131|CiteXplore:10556286|CiteXplore:15579180|HMDB:HMDB00068|CiteXplore:22429969|CiteXplore:23066296|CiteXplore:12851650|CiteXplore:1347802|CiteXplore:9269942|CiteXplore:22569014|CiteXplore:11642745|KNApSAcK:C00029643|CiteXplore:12834252|CiteXplore:16840834|CiteXplore:23185846|CiteXplore:12121816|CiteXplore:22940899|CiteXplore:22905594|CiteXplore:21963816|CiteXplore:9626157|CiteXplore:2159374|Wikipedia:Epinephrine|CiteXplore:9931050|CiteXplore:9327880|CiteXplore:22405854|KEGG COMPOUND:C00788|CiteXplore:22623754|MetaCyc:L-EPINEPHRINE|CiteXplore:15123562|CiteXplore:15300253|CiteXplore:3122251,"
The R-enantiomer of adrenaline. It is a hormone secreted by the adrenal glands resulting in the 'fight-or-flight' response.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:1942|CHEBI:23928,,"
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
|(R)-Adrenaline",,chebi_ontology,"(R)-(-)-Epinephrine|Vasoconstrictine|Suprarenin|L-Adrenaline|Exadrin|
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
|Supracapsulin|CNC[C@H](O)c1ccc(O)c(O)c1|Chelafrin|Epipen|
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
|Epinephran|levoepinephrine|Renoform|Renostyptin|
4-[(1R)-1-hydroxy-2-methylamino-ethyl]benzene-1,2-diol
|(R)-(-)-Epirenamine|Levorenen|Adrin|L-Epinephrine|UCTWMZQNUQWSLP-VIFPVBQESA-N|
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
|Adrenalin|Renaleptine|Levoreninum|Glauposine|Supranephrane|epinefrina|(R)-Epinephrine|Lyodrin|
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
|Scurenaline|Epipen JR|(-)-adrenaline|Isoptoepinal|L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol|Suprarenaline|Surrenine|Renaglandin|Renalina|Eppy|Bronkaid Mist|(R)-(-)-Adnephrine|Hemisine|
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
|Styptirenal|L-Epirenamine|Levorenine|C9H13NO3|epinephrine|Nieraline|Paranephrin|Epinefrina|adrenaline|Nephridine|Mucidrina|Primatene|Epiglaufrin|(R)-(-)-Adrenaline|Renostypticin|(-)-(R)-epinephrine|Ana-Kit|R-(-)-Epinephrine|(-)-Epinephrine|Adnephrine|Hemostatin|Epirenan|L-Methylaminoethanolcatechol|(R)-(-)-adrenaline|Hypernephrin|Sus-phrine|Simplene|Adrenine|Levorenin|Methylarterenol|Hemostasin|Epifrin|Vasotonin|epinephrinum|
(-)-3,4-dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
|
InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1
|
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
|Bosmin|Epinephrin|4-[(1R)-1-hydroxy-2-methylamino-ethyl]pyrocatechol|Adrenal|Takamina|Primatene Mist|
4-[(1R)-1-hydroxy-2-methylaminoethyl]benzene-1,2-diol
",,,CHEBI:28918,,,,,,,,,,,,,,,,,,,,,,,CHEBI:28918,,,,,(R)-adrenaline,,CHEBI:28918,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200347,"[""OR13F1 gene""]",,"An olfactory receptor 13F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 13F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200347,,,,,,,,,,,,,,,,138805,OR13F1,,,,,,,,,,,OR13F1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300038,"[""Endothelin receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300038,,,,,,,,,,,,,,,,,,,,,,,,,,,,Endothelin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200015,"[""CHRNB2 gene""]",,"Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400499,,,,,,,,"Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200015,,,,,,,,,,,,,,,,1141,CHRNB2,,,,,,,,,,,CHRNB2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200463,"[""RYK gene""]",,"The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400221,,,,,,,,"The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200463,,,,,,,,,,,,,,,,6259,RYK,JTK5A,,,,,,,,,,RYK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200092,"[""CSNK2A2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400142,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200092,,,,,,,,,,,,,,,,1459,CSNK2A2,CK2A2,,,,,,,,,,CSNK2A2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200054,"[""CDK11A gene""]",,"This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L1, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions, which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L1 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Many transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of only two have been determined so far. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400254,,,,,,,,"This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L1, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions, which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L1 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Many transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of only two have been determined so far. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200054,,,,,,,,,,,,,,,,728642,CDK11A,CDC2L2|CDC2L3|PITSLREB,,,,,,,,,,CDK11A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200577,"[""FUK gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200577,,,,,,,,,,,,,,,,,,,,,,,,,,,,FUK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000680,"[""kidney cancer cell""]",,"A cell of benign or cancerous growth originating from kidney tissue (for example renal cell carcinoma, hypernephroma).",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A cell of benign or cancerous growth originating from kidney tissue (for example renal cell carcinoma, hypernephroma).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000680,,,,,,,BrendaTissueOBO,kidney tumor cell|renal cancer cell|renal carcinoma cell|kidney carcinoma cell|renal tumor cell,BTO:0000680,,,,,,,,,,,,,,,,,,,kidney cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200520,"[""OR2D2 gene""]",,"An olfactory receptor 2D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H210] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H210] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200520,,,,,,,,,,,,,,,,120776,OR2D2,OR2D1,,,,,,,,,,OR2D2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000219,"[""MET91 in M4K1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000219,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET91 in M4K1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200421,"[""PIK3C3 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491009,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200421,,,,,,,,,,,,,,,,5289,PIK3C3,VPS34,,,,,,,,,,PIK3C3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_799,"[""varicose veins""]",,"A vein disease that is characterized by swollen, twisted veins visible just under the surface of the skin.",false,,,http://purl.obolibrary.org/obo/DOID_866,,,,,,,,"A vein disease that is characterized by swollen, twisted veins visible just under the surface of the skin.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:799,,,,OMIM:192200|NCI:C35114|SNOMEDCT_US_2016_03_01:234053000|SNOMEDCT_US_2016_03_01:276504003|SNOMEDCT_US_2016_03_01:155482006|SNOMEDCT_US_2016_03_01:155468006|SNOMEDCT_US_2016_03_01:399989005|ICD10CM:I83.90|SNOMEDCT_US_2016_03_01:128060009|MESH:D014648|SNOMEDCT_US_2016_03_01:266331000|UMLS_CUI:C0042345|SNOMEDCT_US_2016_03_01:12856003,Venous ectasia|Venous varices|varices|Varix,,disease_ontology,,DOID:799,,,,,,,,,,,,,,,,,,,varicose veins,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2703,"[""synovitis""]",,A connective tissue disease that results_in inflammation located_in synovial membrane that lines a synovial joint which causes pain and swelling.,false,,,http://purl.obolibrary.org/obo/DOID_65,,,,,,,,A connective tissue disease that results_in inflammation located_in synovial membrane that lines a synovial joint which causes pain and swelling.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2703,,,,SNOMEDCT_US_2016_03_01:416209007|MESH:D013585|SNOMEDCT_US_2016_03_01:268092005|UMLS_CUI:C0039103|SNOMEDCT_US_2016_03_01:156666009|NCI:C50766|SNOMEDCT_US_2016_03_01:14107000,,,disease_ontology,,DOID:2703,,,,,,,,,,,,,,,,,,,synovitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003383,"[""semicircular canal""]",,"Three membranous semicircular tubes contained in the bony labyrinth of the inner ear. They are concerned with equilibrium and the interpretation of the bodys position in space. The three canals are set anterior, posterior, and lateral, at right angles to each other and are situated superior and posterior to the vestibule.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Three membranous semicircular tubes contained in the bony labyrinth of the inner ear. They are concerned with equilibrium and the interpretation of the bodys position in space. The three canals are set anterior, posterior, and lateral, at right angles to each other and are situated superior and posterior to the vestibule.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003383,,,,,,,BrendaTissueOBO,ductus semicirculares,BTO:0003383,,,,,,,,,,,,,,,,,,,semicircular canal,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000279,"[""testicular cancer cell""]",,Cancer that forms in tissues of the testis. Testicular cancer usually occurs in young or middle-aged men. Two main types of testicular cancer are seminomas (cancers that grow slowly and are sensitive to radiation therapy) and nonseminomas (different cell types that grow more quickly than seminomas).,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Cancer that forms in tissues of the testis. Testicular cancer usually occurs in young or middle-aged men. Two main types of testicular cancer are seminomas (cancers that grow slowly and are sensitive to radiation therapy) and nonseminomas (different cell types that grow more quickly than seminomas).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000279,,,,,,,BrendaTissueOBO,testicular carcinoma cell,BTO:0000279,,,,,,,,,,,,,,,,,,,testicular cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000085,"[""CDKL3 kinase domain""]",,Cyclin-dependent kinase-like 3; CDKL3; NKIAMRE,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Cyclin-dependent kinase-like 3; CDKL3; NKIAMRE,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000085,,,,,,,,,,,,,,,,,,,200085,,,,,,,,,CDKL3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100663,"[""Olfactory receptor 6k6""]",,"An olfactory receptor 6K6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGW6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6K6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGW6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100663,,,,https://pharos.nih.gov/idg/targets/Q8NGW6,,,,,,,,,,,,,OR6K6,,,Q8NGW6,,,,,,,,Olfactory receptor 6k6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100489,"[""Olfactory receptor 1F12""]",,"An olfactory receptor 1F12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHA8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1F12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHA8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100489,,,,https://pharos.nih.gov/idg/targets/Q8NHA8,,,,,,,,,,,,,OR1F12,OR1F12P,,Q8NHA8,,,,,,,,Olfactory receptor 1F12,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300157,"[""FER family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300157,,,,,,,,,,,,,,,,,,,,,,,,,,,,FER family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200030,"[""ARAF gene""]",,"This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400126,,,,,,,,"This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200030,,,,,,,,,,,,,,,,369,ARAF,ARAF1|PKS|PKS2,,,,,,,,,,ARAF gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391014,"[""Adenylate kinase family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300326,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391014,,,,,,,,,,,,,,,,,,,,,,,,,,,,Adenylate kinase family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_30736,"[""trichloromethyl group""]",CCl3|116.907|-CCl3|0|118.36880,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,trichloromethyl,,chebi_ontology,CCl3|116.907|-CCl3|0|118.36880,,,CHEBI:30736,,,,,,,,,,,,,,,,,,,,,,,CHEBI:30736,,,,,trichloromethyl group,,CHEBI:30736,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200724,"[""OXGR1 gene""]",,"A 2-oxoglutarate receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P68] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A 2-oxoglutarate receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P68] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200724,,,,,,,,,,,,,,,,27199,OXGR1,GPR80|GPR99|P2RY15|P2Y15,,,,,,,,,,OXGR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001203,"[""salivary gland""]",,The glands of the oral cavity whose combined secretion constitutes the saliva.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000765,,,,,,,,The glands of the oral cavity whose combined secretion constitutes the saliva.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001203,,,,,,,BrendaTissueOBO,,BTO:0001203,,,,,,,,,,,,,,,,,,,salivary gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100100,"[""Death-associated protein kinase 3""]",,"death-associated protein kinase 3 (DAPK3)  with  no mutation  in a nonphosphorylated state|A death-associated protein kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43293] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300146,,,,,,,,"death-associated protein kinase 3 (DAPK3)  with  no mutation  in a nonphosphorylated state|A death-associated protein kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43293] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100100,,,,https://pharos.nih.gov/idg/targets/O43293,,,,,,,,,,,,,DAPK3,ZIPK,,O43293,,,,,,,,Death-associated protein kinase 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4308,"[""polyradiculoneuropathy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1389,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4308,,,,MESH:D011129|SNOMEDCT_US_2016_03_01:128078004|UMLS_CUI:C0032587,Polyradiculoneuropathy (disorder),,disease_ontology,,DOID:4308,,,,,,,,,,,,,,,,,,,polyradiculoneuropathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_37,"[""skin disease""]",,An integumentary system disease that is located_in skin.,false,,,http://purl.obolibrary.org/obo/DOID_16,,,,,,,,An integumentary system disease that is located_in skin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:37,,,DOID:6486|DOID:1698|DOID:187|DOID:8948|DOID:1576,SNOMEDCT_US_2016_03_01:80659006|SNOMEDCT_US_2016_03_01:267860005|SNOMEDCT_US_2016_03_01:156292006|UMLS_CUI:C0029574|SNOMEDCT_US_2016_03_01:239001006|UMLS_CUI:C0037277|SNOMEDCT_US_2016_03_01:201095006|SNOMEDCT_US_2016_03_01:199879009|SNOMEDCT_US_2016_03_01:5613003|MESH:D012871|MESH:D012873|SNOMEDCT_US_2016_03_01:156400006|SNOMEDCT_US_2016_03_01:95320005|SNOMEDCT_US_2016_03_01:156445005|NCI:C27554|SNOMEDCT_US_2016_03_01:156396006|ICD9CM:702|SNOMEDCT_US_2016_03_01:201107006|UMLS_CUI:C0037274|SNOMEDCT_US_2016_03_01:267873009|SNOMEDCT_US_2016_03_01:267806002|SNOMEDCT_US_2016_03_01:200580005|NCI:C3371|SNOMEDCT_US_2016_03_01:267859000,Genodermatosis|skin and subcutaneous tissue disease,,disease_ontology,,DOID:37,,,,,,,,,,,,,,,,,,,skin disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_374,"[""nutrition disease""]",,"An acquired metabolic disease that is characterized by an insufficient intake of food or of certain nutrients, by an inability of the body to absorb and use nutrients, or by overconsumption of certain foods.",false,,,http://purl.obolibrary.org/obo/DOID_0060158,,,,,,,,"An acquired metabolic disease that is characterized by an insufficient intake of food or of certain nutrients, by an inability of the body to absorb and use nutrients, or by overconsumption of certain foods.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:374,,,,UMLS_CUI:C3714509|SNOMEDCT_US_2016_03_01:2492009|NCI:C26836|MESH:D009748|SNOMEDCT_US_2016_03_01:191077005,Nutritional disorder,,disease_ontology,,DOID:374,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,nutrition disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000081,"[""reproductive system""]",,"In women, the organs that are directly involved in producing eggs and in conceiving and carrying babies. In men, the organs directly involved in creating, storing, and delivering sperm to fertilize an egg.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"In women, the organs that are directly involved in producing eggs and in conceiving and carrying babies. In men, the organs directly involved in creating, storing, and delivering sperm to fertilize an egg.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000081,,,,,,,BrendaTissueOBO,genitalia|Geschlechtsorgan|organa genitalia|genital system|animal reproductive system|reproductive tissue,BTO:0000081,,,,,,,,,,,,,,,,,,,reproductive system,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_732,"[""urethral disease""]",,A urinary system disease that is located_in the urethra.,false,,,http://purl.obolibrary.org/obo/DOID_18,,,,,,,,A urinary system disease that is located_in the urethra.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:732,,,,ICD10CM:N36.9|SNOMEDCT_US_2016_03_01:197945001|MESH:D014522|NCI:C26903|SNOMEDCT_US_2016_03_01:4985009|UMLS_CUI:C0041969|SNOMEDCT_US_2016_03_01:198551002,urethra disease,,disease_ontology,,DOID:732,,,,,,,,,,,,,,,,,,,urethral disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_731,"[""urinary system benign neoplasm""]",,"An organ system benign neoplasm that is located_in the kidneys, ureteres, bladder or urethra.",false,,,http://purl.obolibrary.org/obo/DOID_0060085|http://purl.obolibrary.org/obo/DOID_18,,,,,,,,"An organ system benign neoplasm that is located_in the kidneys, ureteres, bladder or urethra.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:731,,,,NCI:C3431|SNOMEDCT_US_2016_03_01:126879004|SNOMEDCT_US_2016_03_01:254913005|MESH:D014571|UMLS_CUI:C0042076,tumor of the urinary system|urinary tract neoplasm|neoplasm of urinary system|tumor of urinary tract,,disease_ontology,,DOID:731,,,,,,,,,,,,,,,,,,,urinary system benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12583,"[""velocardiofacial syndrome""]",,A chromosomal disease that has_material_basis_in deletion polymorphisms at chromosome location 22q11 and is characterized by variable developmental problems and schizoid features.,false,,,http://purl.obolibrary.org/obo/DOID_0060388,,,,,,,,A chromosomal disease that has_material_basis_in deletion polymorphisms at chromosome location 22q11 and is characterized by variable developmental problems and schizoid features.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12583,,,,SNOMEDCT_US_2016_03_01:83092002|ICD10CM:Q93.81|SNOMEDCT_US_2016_03_01:205642004|MESH:D004062|OMIM:192430|ICD9CM:758.32|UMLS_CUI:C0220704,VCF-Velocardiofacial syndrome|Shprintzen syndrome|22q11 Deletion Syndrome|deletion 22q11.2 syndrome,,disease_ontology,,DOID:12583,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,velocardiofacial syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12581,"[""olecranon bursitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_204|http://purl.obolibrary.org/obo/DOID_12223,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12581,,,,UMLS_CUI:C0263962|ICD10CM:M70.2|SNOMEDCT_US_2016_03_01:156680002|SNOMEDCT_US_2016_03_01:63517006|SNOMEDCT_US_2016_03_01:425940002|SNOMEDCT_US_2016_03_01:424548006|SNOMEDCT_US_2016_03_01:77299006|SNOMEDCT_US_2016_03_01:202930004|SNOMEDCT_US_2016_03_01:74859007|SNOMEDCT_US_2016_03_01:270542002|ICD9CM:726.33,Elbow bursitis (& olecranon)|Miner's elbow|Shoe boil|Capped elbow|Bursitis of elbow|Bursitis of elbow region|Miners' elbow,,disease_ontology,,DOID:12581,,,,,,,,,,,,,,,,,,,olecranon bursitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12580,"[""Cri-Du-Chat syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0060388,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12580,,,,OMIM:123450|ICD10CM:Q93.4|ICD9CM:758.31|SNOMEDCT_US_2016_03_01:70173007|UMLS_CUI:C0010314|NCI:C34518|MESH:D003410,5p deletion syndrome|5p partial monosomy syndrome (disorder)|Cri-du-chat syndrome|chromosome 5p deletion syndrome|chromosome 5 short arm deletion syndrome,,disease_ontology,,DOID:12580,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Cri-Du-Chat syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1947,"[""trichomoniasis""]",,"A parasitic protozoa infectious disease that is caused by singled-celled protozoan parasites Trichomonas vaginalis or Trichomonas tenax, which infect the urogenital tract and mouth respectively.",false,,,http://purl.obolibrary.org/obo/DOID_2789,,,,,,,,"A parasitic protozoa infectious disease that is caused by singled-celled protozoan parasites Trichomonas vaginalis or Trichomonas tenax, which infect the urogenital tract and mouth respectively.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1947,,,DOID:10996,MESH:D014245|SNOMEDCT_US_2016_03_01:105648001|ICD9CM:131.9|SNOMEDCT_US_2016_03_01:56335008|SNOMEDCT_US_2016_03_01:187364002|ICD10CM:A59|UMLS_CUI:C0040921|SNOMEDCT_US_2016_03_01:187206001|ICD9CM:131|NCI:C35720|ICD10CM:A59.9,,,disease_ontology,trichomonas infection,DOID:1947,,,,,,,,,,,,,,,,,,,trichomoniasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100421,"[""Phosphatidylinositol 3-kinase catalytic subunit type 3""]",,A phosphatidylinositol 3-kinase catalytic subunit type 3 that is encoded in the genome of human. ,false,,,http://www.drugtargetontology.org/dto/DTO_03391009,,,,,,,,A phosphatidylinositol 3-kinase catalytic subunit type 3 that is encoded in the genome of human. ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100421,,,,https://pharos.nih.gov/idg/targets/Q8NEB9,,,,,,,,,,,,,PIK3C3,VPS34,,Q8NEB9,,,,,,,,Phosphatidylinositol 3-kinase catalytic subunit type 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000004,"[""Angiotensin A""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000004,,,,,,,,,,,,,,,,,,,,,,,,,,,,Angiotensin A,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000747,"[""sporangiospore""]",,A spore that develops within a sporangium.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A spore that develops within a sporangium.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000747,,,,,,,BrendaTissueOBO,,BTO:0000747,,,,,,,,,,,,,,,,,,,sporangiospore,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117492,"[""Nuclear receptor ror-gamma""]",,"A nuclear receptor ROR-gamma that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51449] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117464,,,,,,,,"A nuclear receptor ROR-gamma that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51449] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117492,,,,https://pharos.nih.gov/idg/targets/P51449,,,,,,,,,,,,,RORC,RORG,,P51449,,,,,,,,Nuclear receptor ror-gamma,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12678,"[""hypercalcemia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_10575,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12678,,,,SNOMEDCT_US_2016_03_01:166702002|ICD10CM:E83.52|MESH:D006934|ICD9CM:275.42|NCI:C3112|UMLS_CUI:C0020437|SNOMEDCT_US_2016_03_01:66931009|SNOMEDCT_US_2016_03_01:154752005|SNOMEDCT_US_2016_03_01:267505006,,,disease_ontology,,DOID:12678,,,,,,,,,,,,,,,,,,,hypercalcemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12679,"[""nephrocalcinosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_182|http://purl.obolibrary.org/obo/DOID_557,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12679,,,,UMLS_CUI:C0027709|NCI:C84918|SNOMEDCT_US_2016_03_01:190863003|SNOMEDCT_US_2016_03_01:154752005|SNOMEDCT_US_2016_03_01:48638002|MESH:D009397|SNOMEDCT_US_2016_03_01:267505006,,,disease_ontology,,DOID:12679,,,,,,,,,,,,,,,,,,,nephrocalcinosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050013,"[""carbohydrate metabolism disease""]",,An acquired metabolic disease that is characterized by abnormal carbohydrate metabolism.,false,,,http://purl.obolibrary.org/obo/DOID_0060158,,,,,,,,An acquired metabolic disease that is characterized by abnormal carbohydrate metabolism.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050013,,,,,,,disease_ontology,,DOID:0050013,http://purl.obolibrary.org/obo/doid#DO_MGI_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,carbohydrate metabolism disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050012,"[""chikungunya""]",,"A viral infectious disease that results_in infection located_in joint, has_material_basis_in Chikungunya virus, which is transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom arthralgia, and has_symptom maculopapular rash.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in infection located_in joint, has_material_basis_in Chikungunya virus, which is transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom arthralgia, and has_symptom maculopapular rash.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050012,,,,,Chikungunya fever,,disease_ontology,,DOID:0050012,http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,chikungunya,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005693,"[""lateral nerve cord""]",,A cord of nerve tissue that is formed by union of the superior and middle trunks of the brachial plexus and that forms one of the two roots of the median nerve.,false,,,http://purl.obolibrary.org/obo/BTO_0001656|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A cord of nerve tissue that is formed by union of the superior and middle trunks of the brachial plexus and that forms one of the two roots of the median nerve.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005693,Marion,2015-04-14T10:18:09Z,,,,,BrendaTissueOBO,lateral cord,BTO:0005693,,,,,,,,,,,,,,,,,,,lateral nerve cord,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_417,"[""hypersensitivity reaction type II disease""]",,An immune system disease that is an overactive immune response of the body against substances and tissues normally present in the body resulting from an abnormal functioning of the immune system that results in the production of antibodies or T cell directed against the host tissues.,false,,,http://purl.obolibrary.org/obo/DOID_0060056,,,,,,,,An immune system disease that is an overactive immune response of the body against substances and tissues normally present in the body resulting from an abnormal functioning of the immune system that results in the production of antibodies or T cell directed against the host tissues.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:417,,,,OMIM:109100|ICD9CM:720|UMLS_CUI:C0003089,autoimmune disease,,disease_ontology,,DOID:417,,,,,,,,,,,,,,,,,Xref MGI.,,hypersensitivity reaction type II disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_418,"[""systemic scleroderma""]",,"A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies.",false,,,http://purl.obolibrary.org/obo/DOID_37|http://purl.obolibrary.org/obo/DOID_419,,,,,,,,"A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:418,,,,ICD9CM:710.1|SNOMEDCT_US_2016_03_01:89155008|SNOMEDCT_US_2016_03_01:156451000|SNOMEDCT_US_2016_03_01:201440007|SNOMEDCT_US_2016_03_01:128457007|UMLS_CUI:C0036421|MESH:D012595|EFO:0000717|NCI:C72070|ICD10CM:M34.0|ICD10CM:M34.9|SNOMEDCT_US_2016_03_01:268049000,Scleroderma|progressive systemic sclerosis|systemic sclerosis|PSS (progressive systemic sclerosis)|Scleroderma (& [systemic sclerosis])|Scleroderma syndrome,,disease_ontology,,DOID:418,,,,,,,,,,,,,,,,,,,systemic scleroderma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_419,"[""scleroderma""]",,"A rheumatic disease and collagen disease that involves the abnormal growth of connective tissue, which supports the skin and internal organs.",false,,,http://purl.obolibrary.org/obo/DOID_1575|http://purl.obolibrary.org/obo/DOID_854,,,,,,,,"A rheumatic disease and collagen disease that involves the abnormal growth of connective tissue, which supports the skin and internal organs.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:419,,,,SNOMEDCT_US_2016_03_01:89155008|SNOMEDCT_US_2016_03_01:156451000|SNOMEDCT_US_2016_03_01:267874003|SNOMEDCT_US_2016_03_01:201440007|SNOMEDCT_US_2016_03_01:128457007|MESH:D012594|NCI:C26746|SNOMEDCT_US_2016_03_01:287005009|SNOMEDCT_US_2016_03_01:201441006|SNOMEDCT_US_2016_03_01:156454008|UMLS_CUI:C0011644|SNOMEDCT_US_2016_03_01:268049000,dermatosclerosis,,disease_ontology,,DOID:419,,,,,,,,,,,,,,,,,,,scleroderma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005305,"[""corn ear""]",,"The ears are female inflorescences, tightly covered over by several layers of leaves, and so closed-in by them to the stem that they do not show themselves easily until the emergence of the pale yellow silks from the leaf whorl at the end of the ear, e.g. by Zea mays.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000628,,,,,,,,"The ears are female inflorescences, tightly covered over by several layers of leaves, and so closed-in by them to the stem that they do not show themselves easily until the emergence of the pale yellow silks from the leaf whorl at the end of the ear, e.g. by Zea mays.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005305,XPMUser,2012-02-13T11:04:02Z,,,,,BrendaTissueOBO,,BTO:0005305,,,,,,,,,,,,,,,,,,,corn ear,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300249,"[""ABC1-A subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300120,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300249,,,,,,,,,,,,,,,,,,,,,,,,,,,,ABC1-A subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050856,"[""oppositional defiant disorder""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060038,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050856,lschriml,2014-04-15T04:03:08Z,,,,,disease_ontology,,DOID:0050856,,,,,,,,,,,,,,,,,,,oppositional defiant disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050852,"[""limb ischemia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_326,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050852,lschriml,2014-04-15T03:46:27Z,,,,,disease_ontology,,DOID:0050852,,,,,,,,,,,,,,,,,,,limb ischemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050854,"[""Muckle-Wells syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050854,lschriml,2014-04-15T03:53:41Z,,,,,disease_ontology,,DOID:0050854,,,,,,,,,,,,,,,,,,,Muckle-Wells syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_7736,"[""retinal telangiectasia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2462,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:7736,,,,SNOMEDCT_US_2016_03_01:84884003|ICD9CM:362.15|UMLS_CUI:C0154835,,,disease_ontology,,DOID:7736,,,,,,,,,,,,,,,,,,,retinal telangiectasia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5289,"[""uterus leiomyosarcoma""]",,A uterine Corpus sarcoma and leiomyosarcoma and uterine Corpus smooth muscle neoplasm that is located_in the smooth muscle of the uterus.,false,,,http://purl.obolibrary.org/obo/DOID_1967|http://purl.obolibrary.org/obo/DOID_5165,,,,,,,,A uterine Corpus sarcoma and leiomyosarcoma and uterine Corpus smooth muscle neoplasm that is located_in the smooth muscle of the uterus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5289,,,,UMLS_CUI:C0280631|SNOMEDCT_US_2016_03_01:447389009|NCI:C6340,leiomyosarcoma of Corpus Uteri,,disease_ontology,,DOID:5289,,,,,,,,,,,,,,,,,,,uterus leiomyosarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14515,"[""WAGR syndrome""]",,"A chromosomal deletion syndrome that is a nephroblastoma that results_in a rare genetic syndrome in which affected children are predisposed to develop Wilms tumor, Aniridia (absence of the colored part of the eye, the iris), genitourinary anomalies, and mental retardation. The condition results from a deletion on chromosome 11 resulting in the loss of several genes. As such, it is one of the best studied examples of a condition caused by loss of neighbouring (contiguous) genes.",false,,,http://purl.obolibrary.org/obo/DOID_0060388,,,,,,,,"A chromosomal deletion syndrome that is a nephroblastoma that results_in a rare genetic syndrome in which affected children are predisposed to develop Wilms tumor, Aniridia (absence of the colored part of the eye, the iris), genitourinary anomalies, and mental retardation. The condition results from a deletion on chromosome 11 resulting in the loss of several genes. As such, it is one of the best studied examples of a condition caused by loss of neighbouring (contiguous) genes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14515,,,,MESH:D017624|SNOMEDCT_US_2016_03_01:4135001|OMIM:194072|UMLS_CUI:C0206115|NCI:C3718,chromosome 11p13 deletion syndrome|11p partial monosomy syndrome (disorder)|Wilms tumor-Aniridia-Genitourinary Anomalies-Mental Retardation syndrome,,disease_ontology,,DOID:14515,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,WAGR syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400160,"[""MAST family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400160,,,,,,,,,,,,,,,,,,,,,,,,,,,,MAST family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_7457,"[""enterobiasis""]",,A parasitic helminthiasis infectious disease that involves infection of the anus by the pinworm Enterobius vermicularis. The major symptom is perianal itching. Infected people experience perianal pruritus and excoriations from scratching.,false,,,http://purl.obolibrary.org/obo/DOID_883,,,,,,,,A parasitic helminthiasis infectious disease that involves infection of the anus by the pinworm Enterobius vermicularis. The major symptom is perianal itching. Infected people experience perianal pruritus and excoriations from scratching.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:7457,,,DOID:7458,SNOMEDCT_US_2016_03_01:266162007|SNOMEDCT_US_2016_03_01:266222003|ICD10CM:B80|SNOMEDCT_US_2016_03_01:187178006|UMLS_CUI:C0030100|SNOMEDCT_US_2016_03_01:154415009|MESH:D010123|SNOMEDCT_US_2016_03_01:19722001,Oxyuris vermicularis infection (disorder)|Threadworm infection,,disease_ontology,Pinworm infection|oxyuriasis|Enterobius vermicularis infection,DOID:7457,,,,,,,,,,,,,,,,,,,enterobiasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200013,"[""ADCK1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400247,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200013,,,,,,,,,,,,,,,,57143,ADCK1,,,,,,,,,,,ADCK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200717,"[""OR9I1 gene""]",,"An olfactory receptor 9I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 9I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200717,,,,,,,,,,,,,,,,219954,OR9I1,,,,,,,,,,,OR9I1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391011,"[""Pyridoxine kinase family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300324,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391011,,,,,,,,,,,,,,,,,,,,,,,,,,,,Pyridoxine kinase family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400418,"[""GRIK3 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400418,,,,,,,,,,,,,,,,,,,,,,,,,,,,GRIK3 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001773,"[""oocyst""]",,"Zygote, specifically a sporozoan zygote undergoing sporogenous development.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000854,,,,,,,,"Zygote, specifically a sporozoan zygote undergoing sporogenous development.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001773,,,,,,,BrendaTissueOBO,,BTO:0001773,,,,,,,,,,,,,,,,,,,oocyst,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200216,"[""KCNK4 gene""]",,"Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The encoded protein homodimerizes and functions as an outwardly rectifying channel. It is expressed primarily in neural tissues and is stimulated by membrane stretch and polyunsaturated fatty acids. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400359,,,,,,,,"Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The encoded protein homodimerizes and functions as an outwardly rectifying channel. It is expressed primarily in neural tissues and is stimulated by membrane stretch and polyunsaturated fatty acids. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200216,,,,,,,,,,,,,,,,50801,KCNK4,TRAAK,,,,,,,,,,KCNK4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3407,"[""carotid artery disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_6713,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3407,,,,SNOMEDCT_US_2016_03_01:371160000|NCI:C84476|MESH:D002340|UMLS_CUI:C0007273,disorder of carotid artery (disorder),,disease_ontology,,DOID:3407,,,,,,,,,,,,,,,,,,,carotid artery disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100727,"[""P2y purinoceptor 2""]",,"A P2Y purinoceptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41231] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300100,,,,,,,,"A P2Y purinoceptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41231] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100727,,,,https://pharos.nih.gov/idg/targets/P41231,,,,,,,,,,,,,P2RY2,P2RU1,,P41231,,,,,,,,P2y purinoceptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005545,"[""renal epithelial cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005545,Marion,2014-02-21T16:49:05Z,,,,,BrendaTissueOBO,kidney epithelial cell,BTO:0005545,,,,,,,,,,,,,,,,,,,renal epithelial cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001883,"[""acute myeloid leukemia cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000740,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001883,,,,,,,BrendaTissueOBO,acute myelocytic leukemia cell line|acute myelogenous leukemia cell line,BTO:0001883,,,,,,,,,,,,,,,,,,,acute myeloid leukemia cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000231,"[""KPCT kinase domain""]",,Protein kinase C theta type; MGC126514; MGC141919; nPKC-theta; PKCt; PRKCQ; PRKCT,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Protein kinase C theta type; MGC126514; MGC141919; nPKC-theta; PKCt; PRKCQ; PRKCT,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000231,,,,,,,,,,,,,,,,,,,200358,,,,,,,,,KPCT kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/UBERON_0007811,"[""craniocervical region""]",cephalic region|head and neck|cephalic area|cephalic part of animal|head or neck,"The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,http://www.snomedbrowser.com/Codes/Details/361355005|http://linkedlifedata.com/resource/umls/id/C0460004|UMLS:C0460004|WikipediaCategory:Head_and_neck|FMA:280881|ncithesaurus:Head_and_Neck|CALOHA:TS-2356|galen:HeadAndNeck|MA:0000006|EV:0100009,"The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,uberon,cephalic region|head and neck|cephalic area|cephalic part of animal|head or neck,,,,,,,,,,,,,,,,,,,,,,,,,,UBERON:0007811,,,,,craniocervical region,,UBERON:0007811,,http://purl.obolibrary.org/obo/uberon.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002881,"[""neural stem cell""]",,"Neural stem cells are the multipotent stem cells that generate nerve cells. However, since the early 1990s, neural stem cells have been isolated from the adult brain as well as fetal brain tissues. Stem cells in the adult brain are found in the areas called the subventricular zone and the ventricle zone. Another location of brain stem cells occurs in the hippocampus, a special structure of the cerebral cortex related to memory function. Stem cells isolated from these areas are able to divide and to give rise to nerve cells and neuron-supporting cell types in culture.",false,,,http://purl.obolibrary.org/obo/BTO_0002666|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Neural stem cells are the multipotent stem cells that generate nerve cells. However, since the early 1990s, neural stem cells have been isolated from the adult brain as well as fetal brain tissues. Stem cells in the adult brain are found in the areas called the subventricular zone and the ventricle zone. Another location of brain stem cells occurs in the hippocampus, a special structure of the cerebral cortex related to memory function. Stem cells isolated from these areas are able to divide and to give rise to nerve cells and neuron-supporting cell types in culture.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002881,,,,,,,BrendaTissueOBO,neural progenitor cell|neural precursor cell|Nerven-Stammzelle|neural stem progenitor cell|neurale Stammzelle|neuronal precursor cell|neuronal stem cell,BTO:0002881,,,,,,,,,,,,,,,,,,,neural stem cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200526,"[""OR2G6 gene""]",,"An olfactory receptor 2G6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5TZ20] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2G6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5TZ20] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200526,,,,,,,,,,,,,,,,391211,OR2G6,,,,,,,,,,,OR2G6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100220,"[""Metabotropic glutamate receptor 3""]",,"A metabotropic glutamate receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14832] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300059,,,,,,,,"A metabotropic glutamate receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14832] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100220,,,,https://pharos.nih.gov/idg/targets/Q14832,,,,,,,,,,,,,GRM3,GPRC1C|MGLUR3,,Q14832,,,,,,,,Metabotropic glutamate receptor 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003016,"[""SW-1573 cell""]",,Non-small cell lung cancer cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002553,,,,,,,,Non-small cell lung cancer cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003016,,,,,,,BrendaTissueOBO,SW1573 cell,BTO:0003016,,,,,,,,,,,,,,,,,,,SW-1573 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000775,"[""lymphocyte""]",,"Any of the colorless weakly motile cells originating from stem cells and differentiating in lymphoid tissue (as of the thymus or bone marrow) that are the typical cellular elements of lymph, include the cellular mediators of immunity, and constitute 20 to 30 percent of the white blood cells of normal human blood.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000751|http://purl.obolibrary.org/obo/BTO_0001096,,,,,,,,"Any of the colorless weakly motile cells originating from stem cells and differentiating in lymphoid tissue (as of the thymus or bone marrow) that are the typical cellular elements of lymph, include the cellular mediators of immunity, and constitute 20 to 30 percent of the white blood cells of normal human blood.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000775,,,,,,,BrendaTissueOBO,,BTO:0000775,,,,,,,,,,,,,,,,,,,lymphocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100744,"[""Prostaglandin E2 receptor EP2 subtype""]",,"A prostaglandin E2 receptor EP2 subtype that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43116] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A prostaglandin E2 receptor EP2 subtype that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43116] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100744,,,,https://pharos.nih.gov/idg/targets/P43116,,,,,,,,,,,,,PTGER2,,,P43116,,,,,,,,Prostaglandin E2 receptor EP2 subtype,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300464,"[""SCN1B family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300370,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300464,,,,,,,,,,,,,,,,,,,,,,,,,,,,SCN1B family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001355,"[""temporal lobe""]",,"One of the two parietal lobes of the brain located behind the frontal lobe at the top of the brain. Parietal Lobe, Right - Damage to this area can cause visuo-spatial deficits (for example, the patient may have difficulty finding their way around new, or even familiar, places). Parietal Lobe, Left - Damage to this area may disrupt a patient's ability to understand spoken and/or written language. The parietal lobes contain the primary sensory cortex which controls sensation (touch, pressure). Behind the primary sensory cortex is a large association area that controls fine sensation (judgment of texture, weight, size, shape).",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"One of the two parietal lobes of the brain located behind the frontal lobe at the top of the brain. Parietal Lobe, Right - Damage to this area can cause visuo-spatial deficits (for example, the patient may have difficulty finding their way around new, or even familiar, places). Parietal Lobe, Left - Damage to this area may disrupt a patient's ability to understand spoken and/or written language. The parietal lobes contain the primary sensory cortex which controls sensation (touch, pressure). Behind the primary sensory cortex is a large association area that controls fine sensation (judgment of texture, weight, size, shape).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001355,,,,,,,BrendaTissueOBO,temporal cortex,BTO:0001355,,,,,,,,,,,,,,,,,,,temporal lobe,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200559,"[""FLT1 gene""]",,"This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400242,,,,,,,,"This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200559,,,,,,,,,,,,,,,,2321,FLT1,FLT|FRT|VEGFR1,,,,,,,,,,FLT1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9848,"[""endolymphatic hydrops""]",,,false,,,http://purl.obolibrary.org/obo/DOID_9847,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9848,,,,SNOMEDCT_US_2016_03_01:194346003|MESH:D018159|SNOMEDCT_US_2016_03_01:9794007|SNOMEDCT_US_2016_03_01:70831000119103|ICD10CM:H81.0|SNOMEDCT_US_2016_03_01:27621000119100|UMLS_CUI:C0206586,labyrinthine hydrops,,disease_ontology,,DOID:9848,,,,,,,,,,,,,,,,,,,endolymphatic hydrops,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000312,"[""motoneuron""]",,A neuron with a motor function; an efferent neuron conveying motor impulses.,false,,,http://purl.obolibrary.org/obo/BTO_0000938|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A neuron with a motor function; an efferent neuron conveying motor impulses.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000312,,,,,,,BrendaTissueOBO,motor neuron,BTO:0000312,,,,,,,,,,,,,,,,,,,motoneuron,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_17115,"[""L-serine""]","L-2-Amino-3-hydroxypropionic acid|L-(-)-serine|beta-Hydroxyalanine|Serine|(S)-(-)-serine|C3H7NO3|L-Ser|105.09262|S|N[C@@H](CO)C(O)=O|L-Serin|SERINE|Ser|105.043|(S)-2-amino-3-hydroxypropanoic acid|L-3-Hydroxy-2-aminopropionic acid|(2S)-2-amino-3-hydroxypropanoic acid|MTCFGRXMJLQNBG-REOHCLBHSA-N|L-3-Hydroxy-alanine|beta-Hydroxy-L-alanine|0|(S)-serine|InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1|(S)-alpha-Amino-beta-hydroxypropionic acid",The L-enantiomer of serine.,false,,,http://purl.obolibrary.org/obo/CHEBI_33709,,,,,,,Gmelin:2570|PMID:1650428|PMID:22566694|Drug_Central:4127|PMID:19062365|CAS:56-45-1|KNApSAcK:C00001393|MetaCyc:SER|PMID:17439666|DrugBank:DB00133|PMID:22265470|PDBeChem:SER|Reaxys:1721404|KEGG:C00065|Wikipedia:L-serine|ECMDB:ECMDB00187|PMID:21956576|Beilstein:1721404|YMDB:YMDB00112|PMID:22566084|PMID:22393170|KEGG:D00016|HMDB:HMDB00187|PMID:22547037,The L-enantiomer of serine.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:45677|CHEBI:21387|CHEBI:45451|CHEBI:45597|CHEBI:13167|CHEBI:6301|CHEBI:45590|CHEBI:45440,,L-serine|L-Serine,,chebi_ontology,"L-2-Amino-3-hydroxypropionic acid|L-(-)-serine|beta-Hydroxyalanine|Serine|(S)-(-)-serine|C3H7NO3|L-Ser|105.09262|S|N[C@@H](CO)C(O)=O|L-Serin|SERINE|Ser|105.043|(S)-2-amino-3-hydroxypropanoic acid|L-3-Hydroxy-2-aminopropionic acid|(2S)-2-amino-3-hydroxypropanoic acid|MTCFGRXMJLQNBG-REOHCLBHSA-N|L-3-Hydroxy-alanine|beta-Hydroxy-L-alanine|0|(S)-serine|InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1|(S)-alpha-Amino-beta-hydroxypropionic acid",,,CHEBI:17115,,,,,,,,,,,,,,,,,,,,,,,CHEBI:17115,,,,,L-serine,,CHEBI:17115,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300155,"[""FAK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300155,,,,,,,,,,,,,,,,,,,,,,,,,,,,FAK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001130,"[""prostate gland cancer cell""]",,A malignant tumour cell of glandular origin in the prostate. Over 95% are adenocarcinomas.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A malignant tumour cell of glandular origin in the prostate. Over 95% are adenocarcinomas.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001130,,,,,,,BrendaTissueOBO,prostate cancer cell|prostate tumour cell|prostate carcinoma cell|prostate tumor cell,BTO:0001130,,,,,,,,,,,,,,,,,,,prostate gland cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200287,"[""SLC26A1 gene""]",,"This gene is a member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures, but have markedly different tissue expression patterns. This gene is primarily expressed in the liver, pancreas, and brain. Three splice variants that encode different isoforms have been identified. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400368,,,,,,,,"This gene is a member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures, but have markedly different tissue expression patterns. This gene is primarily expressed in the liver, pancreas, and brain. Three splice variants that encode different isoforms have been identified. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200287,,,,,,,,,,,,,,,,10861,SLC26A1,SAT1,,,,,,,,,,SLC26A1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002157,"[""endochondral bone""]",,Refers to skeletal elements which are formed in cartilage and which later ossify. Also called replacement bone because it gradually replaces the pre-existing cartilage.,false,,,http://purl.obolibrary.org/obo/UBERON_0001474|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000140,,,,,,,,Refers to skeletal elements which are formed in cartilage and which later ossify. Also called replacement bone because it gradually replaces the pre-existing cartilage.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002157,,,,,,,BrendaTissueOBO,replacement bone|cartilaginous bone,BTO:0002157,,,,,,,,,,,,,,,,,,,endochondral bone,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200437,"[""PRKRA gene""]",,"This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,"This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200437,,,,,,,,,,,,,,,,8575,PRKRA,PACT|RAX,,,,,,,,,,PRKRA gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004859,"[""Nthy-ori 3-1 cell""]",,Human thyroid follicular epithelial cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001876,,,,,,,,Human thyroid follicular epithelial cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004859,mgr,2010-10-11T02:42:52Z,,,,,BrendaTissueOBO,Nthy ori 3.1 cell |Nthy-ori 3.1 cell|NTHY-Ori-3-1 cell,BTO:0004859,,,,,,,,,,,,,,,,,,,Nthy-ori 3-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400514,"[""GABRB3 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400514,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRB3 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003906,"[""uroepithelium""]",,"The epithelium of the urinary tract. The lining of the ureters, bladder, and urethra.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000416,,,,,,,,"The epithelium of the urinary tract. The lining of the ureters, bladder, and urethra.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003906,,,,,,,BrendaTissueOBO,urothelium,BTO:0003906,,,,,,,,,,,,,,,,,,,uroepithelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200141,"[""ERBB4 gene""]",,"This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400152,,,,,,,,"This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200141,,,,,,,,,,,,,,,,2066,ERBB4,HER4,,,,,,,,,,ERBB4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80256,"[""Neuropeptide W-30""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16032,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80256,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80256,,,,,Neuropeptide W-30,,CHEBI:80256,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100778,"[""Taste receptor type 2 member 14""]",,"A taste receptor type 2 member 14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYV8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300014,,,,,,,,"A taste receptor type 2 member 14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYV8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100778,,,,https://pharos.nih.gov/idg/targets/Q9NYV8,,,,,,,,,,,,,TAS2R14,,,Q9NYV8,,,,,,,,Taste receptor type 2 member 14,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100774,"[""Somatostatin receptor type 5""]",,"A somatostatin receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35346] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A somatostatin receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35346] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100774,,,,https://pharos.nih.gov/idg/targets/P35346,,,,,,,,,,,,,SSTR5,,,P35346,,,,,,,,Somatostatin receptor type 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3008,"[""invasive ductal carcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3007,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3008,,,DOID:3005,SNOMEDCT_US_2016_03_01:408643008|NCI:C4017|UMLS_CUI:C1527349|MESH:D018270|SNOMEDCT_US_2016_03_01:58477004|UMLS_CUI:C1134719|NCI:C4194,"Infiltrating ductal carcinoma of breast|ductal adenocarcinoma|Invasive ductal carcinoma, NST",,disease_ontology,,DOID:3008,,,,,,,,,,,,,,,,,,,invasive ductal carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000093,"[""MET104 in TAK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000093,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET104 in TAK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1107,"[""esophageal carcinoma""]",,A esophageal cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.,false,,,http://purl.obolibrary.org/obo/DOID_5041|http://purl.obolibrary.org/obo/DOID_305,,,,,,,,A esophageal cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1107,,,,NCI:C3513|SNOMEDCT_US_2016_03_01:255079005|SNOMEDCT_US_2016_03_01:372138000|EFO:0002916|UMLS_CUI:C0152018|SNOMEDCT_US_2016_03_01:154441003|SNOMEDCT_US_2016_03_01:93785002,carcinoma OF ESOPHAGUS|cancer of oesophagus|cancer of esophagus|carcinoma of esophagus (disorder)|carcinoma of oesophagus,,disease_ontology,,DOID:1107,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,esophageal carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11077,"[""brucellosis""]",,"A primary bacterial infectious disease that is caused by the bacteria of the genus Brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. The disease has_symptom fever, has_symptom sweat, has_symptom headache, has_symptom back pain, has_symptom physical weakness, has_symptom joint pain and has_symptom fatigue.",false,,,http://purl.obolibrary.org/obo/DOID_0050338,,,,,,,,"A primary bacterial infectious disease that is caused by the bacteria of the genus Brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. The disease has_symptom fever, has_symptom sweat, has_symptom headache, has_symptom back pain, has_symptom physical weakness, has_symptom joint pain and has_symptom fatigue.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11077,,,DOID:0050060,ICD10CM:A23|UMLS_CUI:C0006309|ICD9CM:023|ICD10CM:A23.9|ICD9CM:023.9|SNOMEDCT_US_2016_03_01:154296006|SNOMEDCT_US_2016_03_01:186310006|NCI:C84602|SNOMEDCT_US_2016_03_01:187304000|SNOMEDCT_US_2016_03_01:111804008|SNOMEDCT_US_2016_03_01:75702008|MESH:D002006,undulant fever|Maltese fever,,disease_ontology,Malta fever|Gibraltar fever|Mediterranean fever|Bang's disease,DOID:11077,http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease|http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,brucellosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200533,"[""PBK gene""]",,"This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400236,,,,,,,,"This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200533,,,,,,,,,,,,,,,,55872,PBK,TOPK,,,,,,,,,,PBK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100628,"[""Olfactory receptor 5I1""]",,"An olfactory receptor 5I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13606] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13606] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100628,,,,https://pharos.nih.gov/idg/targets/Q13606,,,,,,,,,,,,,OR5I1,OLF1,,Q13606,,,,,,,,Olfactory receptor 5I1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9993,"[""hypoglycemia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4194|http://purl.obolibrary.org/obo/DOID_1428,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9993,,,,UMLS_CUI:C0020615|SNOMEDCT_US_2016_03_01:154693009|NCI:C3126|SNOMEDCT_US_2016_03_01:190433001|ICD10CM:E16.2|SNOMEDCT_US_2016_03_01:154691006|MESH:D007003|SNOMEDCT_US_2016_03_01:271327008|SNOMEDCT_US_2016_03_01:302866003|SNOMEDCT_US_2016_03_01:66694000|SNOMEDCT_US_2016_03_01:190436009|ICD9CM:251.2|SNOMEDCT_US_2016_03_01:237630007,Hypoglycaemia,,disease_ontology,,DOID:9993,,,,,,,,,,,,,,,,,,,hypoglycemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000213,"[""KGP2 kinase domain""]",,"Protein kinase, cGMP-dependent, type II; cGKII; PKG2; PRKG2; PRKGR2",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Protein kinase, cGMP-dependent, type II; cGKII; PKG2; PRKG2; PRKGR2",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000213,,,,,,,,,,,,,,,,,,,200363,,,,,,,,,KGP2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100049,"[""Serine/threonine-protein kinase brsk2""]",,"serine/threonine-protein kinase brsk2 (BRSK2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase BRSK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IWQ3] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300253,,,,,,,,"serine/threonine-protein kinase brsk2 (BRSK2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase BRSK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IWQ3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100049,,,,https://pharos.nih.gov/idg/targets/Q8IWQ3,,,,,,,,,,,,,BRSK2,C11orf7|PEN11B|SADA|STK29,,Q8IWQ3,,,,,,,,Serine/threonine-protein kinase brsk2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000026,"[""Spinorphin""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000026,,,,,,,,,,,,,,,,,,,,,,,,,,,,Spinorphin,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8649,"[""tongue cancer""]",,,false,,,http://purl.obolibrary.org/obo/DOID_10944|http://purl.obolibrary.org/obo/DOID_8618,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8649,,,DOID:9196|DOID:8779|DOID:8900|DOID:8999|DOID:9068|DOID:8648|DOID:9058|DOID:8940,SNOMEDCT_US_2016_03_01:187638000|SNOMEDCT_US_2016_03_01:93868009|NCI:C9345|ICD9CM:141.6|UMLS_CUI:C0474963|ICD10CM:C02.9|ICD9CM:141.5|SNOMEDCT_US_2016_03_01:94100005|ICD10CM:C01|SNOMEDCT_US_2016_03_01:187636001|SNOMEDCT_US_2016_03_01:187642002|UMLS_CUI:C0496755|SNOMEDCT_US_2016_03_01:363377003|SNOMEDCT_US_2016_03_01:93773005|NCI:C3524|SNOMEDCT_US_2016_03_01:187632004|ICD10CM:C02.2|ICD10CM:C02.4|SNOMEDCT_US_2016_03_01:94101009|UMLS_CUI:C0153350|SNOMEDCT_US_2016_03_01:187646004|SNOMEDCT_US_2016_03_01:187644001|ICD9CM:141.0|MESH:D014062|ICD9CM:141|SNOMEDCT_US_2016_03_01:371974006|ICD10CM:C02.0|ICD9CM:141.9|SNOMEDCT_US_2016_03_01:187637005|UMLS_CUI:C0153351|UMLS_CUI:C0153349|SNOMEDCT_US_2016_03_01:93687001|SNOMEDCT_US_2016_03_01:363376007|ICD9CM:141.1|ICD9CM:141.2|ICD10CM:C02.1|UMLS_CUI:C0684333|UMLS_CUI:C0153356|SNOMEDCT_US_2016_03_01:187633009|SNOMEDCT_US_2016_03_01:363375006|SNOMEDCT_US_2016_03_01:93848003|SNOMEDCT_US_2016_03_01:94134006|ICD9CM:141.3,"malignant neoplasm of fixed part of tongue NOS|malignant neoplasm of dorsal tongue NOS|malignant neoplasm of tip and/or lateral border of tongue|malignant neoplasm of base of tongue|malignant tumor of Posterior Tongue|malignant neoplasm of other sites of tongue (disorder)|malignant tumor of anterior two-thirds of tongue (disorder)|malignant neoplasm of fixed part of tongue NOS (disorder)|malignant neoplasm of other sites of tongue|malignant neoplasm of ventral tongue surface NOS (disorder)|malignant neoplasm of ventral surface of tongue|malignant neoplasm of lingual tonsil|malignant tumor of lingual tonsil|malignant neoplasm of tongue NOS (disorder)|Tongue neoplasm malignant stage Unspecified|malignant neoplasm of dorsal surface of tongue|malignant tumor of tongue (disorder)|malignant neoplasm of tongue, tip and lateral border (disorder)|malignant tumor of lingual tonsil (disorder)|malignant neoplasm of border of tongue|malignant neoplasm of dorsum of tongue NOS (disorder)|malignant tumor of mobile part of tongue|malignant neoplasm of junctional zone of tongue|malignant neoplasm of tip and lateral border of tongue|malignant neoplasm of mobile part of tongue NOS|malignant neoplasm of anterior two-thirds of tongue, part unspecified|malignant neoplasm of tongue|malignant tumor of base of tongue (disorder)|malignant neoplasm of anterior 2/3 of tongue unspecified (disorder)|malignant neoplasm of tongue NOS|malignant neoplasm of tongue, NOS",,disease_ontology,,DOID:8649,,,,,,,,,,,,,,,,,,,tongue cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200269,"[""P2RX6 gene""]",,"The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq, Apr 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400364,,,,,,,,"The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq, Apr 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200269,,,,,,,,,,,,,,,,9127,P2RX6,P2RXL1|P2X6,,,,,,,,,,P2RX6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9111,"[""cutaneous leishmaniasis""]",,"A leishmaniasis that involves skin infection caused by Leishmania species, resulting in one or more cutaneous lesions.",false,,,http://purl.obolibrary.org/obo/DOID_9065,,,,,,,,"A leishmaniasis that involves skin infection caused by Leishmania species, resulting in one or more cutaneous lesions.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9111,,,DOID:13553|DOID:9110|DOID:9122|DOID:9167,ICD10CM:B55.1|NCI:C34768|MESH:D016773|UMLS_CUI:C0023283|SNOMEDCT_US_2016_03_01:240637006,Asian Desert Cutaneous Leishmaniasis|diffuse cutaneous leishmaniasis|Leproid leishmaniasis,,disease_ontology,,DOID:9111,http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,cutaneous leishmaniasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_314,"[""tenosynovial giant cell tumor""]",,,false,,,http://purl.obolibrary.org/obo/DOID_200,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:314,,,,NCI:C3402|SNOMEDCT_US_2016_03_01:310605004|SNOMEDCT_US_2016_03_01:71508003|ICD9CM:727.02|SNOMEDCT_US_2016_03_01:95413004|UMLS_CUI:C1318543|SNOMEDCT_US_2016_03_01:95412009|SNOMEDCT_US_2016_03_01:128777004,Giant cell tumor of Tenosynovium|Giant cell tumor of tendon sheath|fibrous histiocytoma of tendon sheath (disorder),,disease_ontology,,DOID:314,,,,,,,,,,,,,,,,,,,tenosynovial giant cell tumor,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_319,"[""spinal cord disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_331,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:319,,,,SNOMEDCT_US_2016_03_01:155020007|SNOMEDCT_US_2016_03_01:192908002|UMLS_CUI:C0037928|SNOMEDCT_US_2016_03_01:267695005|SNOMEDCT_US_2016_03_01:192913003|SNOMEDCT_US_2016_03_01:267587000|NCI:C97110|SNOMEDCT_US_2016_03_01:95648003|MESH:D013118|ICD10CM:G95.9|SNOMEDCT_US_2016_03_01:48522003|ICD9CM:336.9,,,disease_ontology,myelopathy,DOID:319,,,,,,,,,,,,,,,,,,,spinal cord disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000839,"[""mesoderm""]",,"Middle of the three germ layers, gives rise to the musculoskeletal, blood, vascular and urinogenital systems, to connective tissue (including that of dermis) and contributes to some glands.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000556,,,,,,,,"Middle of the three germ layers, gives rise to the musculoskeletal, blood, vascular and urinogenital systems, to connective tissue (including that of dermis) and contributes to some glands.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000839,,,,,,,BrendaTissueOBO,,BTO:0000839,,,,,,,,,,,,,,,,,,,mesoderm,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000344,"[""THR319 in LYN""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000344,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR319 in LYN,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000274,"[""MK09 kinase domain""]",,Mitogen-activated protein kinase 9; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; JNK-55; MAPK9; p54a; p54aSAPK; PRKM9; SAPK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase 9; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; JNK-55; MAPK9; p54a; p54aSAPK; PRKM9; SAPK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000274,,,,,,,,,,,,,,,,,,,200212,,,,,,,,,MK09 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000034,"[""17 beta-estradiol""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000034,,,,,,,,,,,,,,,,,,,,,,,,,,,,17 beta-estradiol,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200347,"[""MYLK2 gene""]",,"This gene encodes a myosin light chain kinase, a calcium/calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400196,,,,,,,,"This gene encodes a myosin light chain kinase, a calcium/calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200347,,,,,,,,,,,,,,,,85366,MYLK2,,,,,,,,,,,MYLK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400263,"[""CDK9 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400136,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400263,,,,,,,,,,,,,,,,,,,,,,,,,,,,CDK9 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5667,"[""sweat gland carcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2095|http://purl.obolibrary.org/obo/DOID_3451,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5667,,,,SNOMEDCT_US_2016_03_01:254707006|NCI:C6938|UMLS_CUI:C1412016|SNOMEDCT_US_2016_03_01:254708001|SNOMEDCT_US_2016_03_01:32272007,carcinoma of the Sweat gland,,disease_ontology,,DOID:5667,,,,,,,,,,,,,,,,,,,sweat gland carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100034,"[""Serine/threonine-protein kinase atr""]",,"A serine/threonine-protein kinase ATR that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13535] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300251,,,,,,,,"A serine/threonine-protein kinase ATR that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13535] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100034,,,,https://pharos.nih.gov/idg/targets/Q13535,,,,,,,,,,,,,ATR,FRP1,,Q13535,,,,,,,,Serine/threonine-protein kinase atr,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000210,"[""KCC2D kinase domain""]",,Calcium/calmodulin-dependent protein kinase type II subunit delta; CaM kinase II subunit delta; CAMK2D; CAMKD; DKFZp686G23119; DKFZp686I2288; MGC44911,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Calcium/calmodulin-dependent protein kinase type II subunit delta; CaM kinase II subunit delta; CAMK2D; CAMKD; DKFZp686G23119; DKFZp686I2288; MGC44911,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000210,,,,,,,,,,,,,,,,,,,200065,,,,,,,,,KCC2D kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000804,"[""J-774A.1 cell""]",,"Mouse monocytes-macrophages, established from a tumor in a female BALB/c mouse in 1968; cells were described to synthesize lysozyme and interleukin-1 and to have receptors for immunoglobulin and complement.",false,,,http://purl.obolibrary.org/obo/BTO_0002279|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Mouse monocytes-macrophages, established from a tumor in a female BALB/c mouse in 1968; cells were described to synthesize lysozyme and interleukin-1 and to have receptors for immunoglobulin and complement.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000804,,,,,,,BrendaTissueOBO,J774A.1 cell,BTO:0000804,,,,,,,,,,,,,,,,,,,J-774A.1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4045,"[""muscle cancer""]",,A musculoskeletal system cancer that is located_in muscle.,false,,,http://purl.obolibrary.org/obo/DOID_0060100,,,,,,,,A musculoskeletal system cancer that is located_in muscle.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4045,,,DOID:4046,ICD10CM:C49|MESH:D019042|MESH:D009217|SNOMEDCT_US_2016_03_01:93913006|UMLS_CUI:C0027095|SNOMEDCT_US_2016_03_01:20667008|UMLS_CUI:C0684743|NCI:C4883|SNOMEDCT_US_2016_03_01:363495004,"Myosarcoma (morphologic abnormality)|malignant tumor of muscle (disorder)|malignant neoplasm of muscle, NOS|malignant tumor of the Muscle|myosarcoma",,disease_ontology,,DOID:4045,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,muscle cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200049,"[""BRSK2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400253,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200049,,,,,,,,,,,,,,,,9024,BRSK2,C11orf7|PEN11B|SADA,,,,,,,,,,BRSK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000018,"[""ILE110 in LOK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30009,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,ILE110 in LOK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2825,"[""nose disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_974,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2825,,,,SNOMEDCT_US_2016_03_01:89488007|UMLS_CUI:C0028432|MESH:D009668,disorder of the nose (disorder)|nasal disorder,,disease_ontology,,DOID:2825,,,,,,,,,,,,,,,,,,,nose disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001533,"[""gastrointestinal cancer cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001533,,,,,,,BrendaTissueOBO,,BTO:0001533,,,,,,,,,,,,,,,,,,,gastrointestinal cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1800,"[""neuroendocrine carcinoma""]",,A carcinoma that derives_from neuroendocrine cells.,false,,,http://purl.obolibrary.org/obo/DOID_305,,,,,,,,A carcinoma that derives_from neuroendocrine cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1800,,,,SNOMEDCT_US_2016_03_01:55937004|MESH:D018278|NCI:C3773|SNOMEDCT_US_2016_03_01:253000007|UMLS_CUI:C0206695,,,disease_ontology,,DOID:1800,,,,,,,,,,,,,,,,,,,neuroendocrine carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100014,"[""Adenosine receptor a2a""]",,"An adenosine receptor A2a that is encoded in the genome of human. [PRO:WCB, UniProtKB:P29274] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300018,,,,,,,,"An adenosine receptor A2a that is encoded in the genome of human. [PRO:WCB, UniProtKB:P29274] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100014,,,,https://pharos.nih.gov/idg/targets/P29274,,,,,,,,,,,,,ADORA2A,ADORA2,,P29274,,,,,,,,Adenosine receptor a2a,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_52392,"[""2-arachidonoylglycerol""]","2-AG|1-Monoacylglyceride|MG(20:4)|
(all-Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoate
|2-Arachidonyl-glycerol|
(5Z,8Z,11Z,14Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoic acid
|2-(5Z,8Z,11Z,14Z-Eicosatetraenoyl)-rac-glycerol|2-Arachidonyl glycerol|MG(0:0/20:4n6)|beta-Monoacylglycerol|RCRCTBLIHCHWDZ-DOFZRALJSA-N|2-Monoarachidonoylglycerolbeta-monoacylglycerol|
(5Z,8Z,11Z,14Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoate
|2-Arachidonoyl-glycerol|MAG(20:4)|b-Monoacylglycerol|MAG(0:0/20:4)|2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol|MG(0:0/20:4)|MAG(0:0/20:4w6)|C23H38O4|MAG(0:0/20:4n6)|2-Ara-Gl|MG(0:0/20:4w6)|
InChI=1S/C23H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(26)27-22(20-24)21-25/h6-7,9-10,12-13,15-16,22,24-25H,2-5,8,11,14,17-21H2,1H3/b7-6-,10-9-,13-12-,16-15-
|
(all-Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoic acid
|MG(0:0/20:4(5Z,8Z,11Z,14Z)/0:0)|1-Monoacylglycerol|[H]C(CO)(CO)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC","
An endocannabinoid and an endogenous agonist of the cannabinoid receptors (CB1 and CB2). It is an ester formed from omega-6-arachidonic acid and glycerol.
",false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,KEGG COMPOUND:53847-30-6|LIPID MAPS:LMGL01010023|CiteXplore:12878451|CiteXplore:15543349|HMDB:HMDB04666|CiteXplore:21177788|CiteXplore:16278487|MetaCyc:CPD-12600|KEGG COMPOUND:C13856|Reaxys:8167264|ChemIDplus:53847-30-6|CiteXplore:16678907|CiteXplore:18771906|Wikipedia:2-Arachidonoylglycerol|CiteXplore:21359215|CiteXplore:16515464,"
An endocannabinoid and an endogenous agonist of the cannabinoid receptors (CB1 and CB2). It is an ester formed from omega-6-arachidonic acid and glycerol.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:52365|CHEBI:34261,,"
1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
|2-Arachidonoylglycerol",,chebi_ontology,"2-AG|1-Monoacylglyceride|MG(20:4)|
(all-Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoate
|2-Arachidonyl-glycerol|
(5Z,8Z,11Z,14Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoic acid
|2-(5Z,8Z,11Z,14Z-Eicosatetraenoyl)-rac-glycerol|2-Arachidonyl glycerol|MG(0:0/20:4n6)|beta-Monoacylglycerol|RCRCTBLIHCHWDZ-DOFZRALJSA-N|2-Monoarachidonoylglycerolbeta-monoacylglycerol|
(5Z,8Z,11Z,14Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoate
|2-Arachidonoyl-glycerol|MAG(20:4)|b-Monoacylglycerol|MAG(0:0/20:4)|2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol|MG(0:0/20:4)|MAG(0:0/20:4w6)|C23H38O4|MAG(0:0/20:4n6)|2-Ara-Gl|MG(0:0/20:4w6)|
InChI=1S/C23H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(26)27-22(20-24)21-25/h6-7,9-10,12-13,15-16,22,24-25H,2-5,8,11,14,17-21H2,1H3/b7-6-,10-9-,13-12-,16-15-
|
(all-Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoic acid
|MG(0:0/20:4(5Z,8Z,11Z,14Z)/0:0)|1-Monoacylglycerol|[H]C(CO)(CO)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC",,,CHEBI:52392,,,,,,,,,,,,,,,,,,,,,,,CHEBI:52392,,,,,2-arachidonoylglycerol,,CHEBI:52392,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100017,"[""Atypical chemokine receptor 1""]",,"A duffy antigen/chemokine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q16570] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300031,,,,,,,,"A duffy antigen/chemokine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q16570] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100017,,,,https://pharos.nih.gov/idg/targets/Q16570,,,,,,,,,,,,,ACKR1,DARC|FY|GPD,,Q16570,,,,,,,,Atypical chemokine receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000062,"[""amastigote""]",,"Any of the bodies representing the morphologic (leishmanial) stage in the life cycle of all trypanosomatid protozoa resembling the typical adult form of members of the genus Leishmania, in which the oval or round cell has a nucleus, kinetoplast, and basal body but lacks a free-flowing flagellum, the flagellum being either very short or entirely absent.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000092,,,,,,,,"Any of the bodies representing the morphologic (leishmanial) stage in the life cycle of all trypanosomatid protozoa resembling the typical adult form of members of the genus Leishmania, in which the oval or round cell has a nucleus, kinetoplast, and basal body but lacks a free-flowing flagellum, the flagellum being either very short or entirely absent.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000062,,,,,,,BrendaTissueOBO,Leishman-Donovan body|aflagellate form|leishmanial form|spheromastigote|micromastigote,BTO:0000062,,,,,,,,,,,,,,,,,,,amastigote,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100339,"[""Olfactory receptor 13A1""]",,"An olfactory receptor 13A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 13A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100339,,,,https://pharos.nih.gov/idg/targets/Q8NGR1,,,,,,,,,,,,,OR13A1,,,Q8NGR1,,,,,,,,Olfactory receptor 13A1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200191,"[""IRAK2 gene""]",,"IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400166,,,,,,,,"IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200191,,,,,,,,,,,,,,,,3656,IRAK2,,,,,,,,,,,IRAK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100102,"[""Serine/threonine-protein kinase dclk1""]",,"serine/threonine-protein kinase dclk1 (DCLK1)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase DCLK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15075] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300147,,,,,,,,"serine/threonine-protein kinase dclk1 (DCLK1)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase DCLK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15075] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100102,,,,https://pharos.nih.gov/idg/targets/O15075,,,,,,,,,,,,,DCLK1,DCAMKL1|DCDC3A|KIAA0369,,O15075,,,,,,,,Serine/threonine-protein kinase dclk1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100172,"[""Kv channel-interacting protein 1""]",,"A Kv channel-interacting protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZI2] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,"A Kv channel-interacting protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZI2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100172,,,,https://pharos.nih.gov/idg/targets/Q9NZI2,,,,,,,,,,,,,KCNIP1,KCHIP1|VABP,,Q9NZI2,,,,,,,,Kv channel-interacting protein 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001967,"[""cervical cancer cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001966,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001967,,,,,,,BrendaTissueOBO,cervical carcinoma cell line|cervix cancer cell,BTO:0001967,,,,,,,,,,,,,,,,,,,cervical cancer cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200321,"[""MAPK9 gene""]",,"The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400293,,,,,,,,"The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200321,,,,,,,,,,,,,,,,5601,MAPK9,JNK2|PRKM9|SAPK1A,,,,,,,,,,MAPK9 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200438,"[""OR56A1 gene""]",,"An olfactory receptor 56A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 56A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200438,,,,,,,,,,,,,,,,120796,OR56A1,,,,,,,,,,,OR56A1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100412,"[""Phosphatidylinositol 4-kinase alpha""]",,"A phosphatidylinositol 4-kinase alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42356] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391003,,,,,,,,"A phosphatidylinositol 4-kinase alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42356] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100412,,,,https://pharos.nih.gov/idg/targets/P42356,,,,,,,,,,,,,PI4KA,PIK4|PIK4CA,,P42356,,,,,,,,Phosphatidylinositol 4-kinase alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100510,"[""Ste20-related kinase adapter protein beta""]",,"A STE20-related kinase adapter protein beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9C0K7] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300187,,,,,,,,"A STE20-related kinase adapter protein beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9C0K7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100510,,,,https://pharos.nih.gov/idg/targets/Q9C0K7,,,,,,,,,,,,,STRADB,ALS2CR2|ILPIP,,Q9C0K7,,,,,,,,Ste20-related kinase adapter protein beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300337,"[""PMP-22/EMP/MP20 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300337,,,,,,,,,,,,,,,,,,,,,,,,,,,,PMP-22/EMP/MP20 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2485,"[""phosphorus metabolism disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0050032,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2485,,,,UMLS_CUI:C0031707|MESH:D010760|SNOMEDCT_US_2016_03_01:190858002|SNOMEDCT_US_2016_03_01:87049008|SNOMEDCT_US_2016_03_01:190862008|SNOMEDCT_US_2016_03_01:154752005|NCI:C97095|ICD9CM:275.3|SNOMEDCT_US_2016_03_01:267505006,disorder of phosphorus metabolism NOS (disorder)|disorder of phosphorus metabolism|disorder of phosphorus metabolism (disorder)|Phosphorus disorder|phosphorus metabolism disorder,,disease_ontology,,DOID:2485,,,,,,,,,,,,,,,,,,,phosphorus metabolism disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491035,"[""FRAP subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400129,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491035,,,,,,,,,,,,,,,,,,,,,,,,,,,,FRAP subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491044,"[""PKLR gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400324,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491044,,,,,,,,,,,,,,,,,PKLR,,,,,,,,,,,PKLR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200222,"[""CAMK4 gene""]",,"The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400171,,,,,,,,"The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200222,,,,,,,,,,,,,,,,814,CAMK4,CAMK|CAMK-GR|CAMKIV,,,,,,,,,,CAMK4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117518,"[""Mineralocorticoid receptor""]",,"A mineralocorticoid receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08235] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117474,,,,,,,,"A mineralocorticoid receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08235] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117518,,,,https://pharos.nih.gov/idg/targets/P08235,,,,,,,,,,,,,NR3C2,MLR,,P08235,,,,,,,,Mineralocorticoid receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000321,"[""THR302 in SRMS""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000321,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR302 in SRMS,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8867,"[""molluscum contagiosum""]",,"A viral infectious disease that results_in infection located_in skin, has_material_basis_in Molluscum contagiosum virus, which is transmitted_by contact with the skin, and transmitted_by fomites. The infection has_symptom lesions which are flesh-colored with a pit in the center.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in infection located_in skin, has_material_basis_in Molluscum contagiosum virus, which is transmitted_by contact with the skin, and transmitted_by fomites. The infection has_symptom lesions which are flesh-colored with a pit in the center.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8867,,,,SNOMEDCT_US_2016_03_01:40070004|SNOMEDCT_US_2016_03_01:154360009|ICD10CM:B08.1|MESH:D008976|UMLS_CUI:C0026393|ICD9CM:078.0,,,disease_ontology,,DOID:8867,http://purl.obolibrary.org/obo/doid#sexually_transmitted_infectious_disease,,,,,,,,,,,,,,,,,,molluscum contagiosum,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400406,"[""CNGB1 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400343,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400406,,,,,,,,,,,,,,,,,,,,,,,,,,,,CNGB1 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000102,"[""CSNK2A1 kinase domain""]",,"Casein kinase 2, alpha 1 polypeptide; CK2A1; CKII; CSNK2A1",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Casein kinase 2, alpha 1 polypeptide; CK2A1; CKII; CSNK2A1",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000102,,,,,,,,,,,,,,,,,,,200103,,,,,,,,,CSNK2A1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100402,"[""Pseudopodium-enriched atypical kinase 1""]",,A pseudopodium-enriched atypical kinase 1 that is encoded in the genome of human. ,false,,,http://www.drugtargetontology.org/dto/DTO_03300204,,,,,,,,A pseudopodium-enriched atypical kinase 1 that is encoded in the genome of human. ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100402,,,,https://pharos.nih.gov/idg/targets/Q9H792,,,,,,,,,,,,,PEAK1,KIAA2002,,Q9H792,,,,,,,,Pseudopodium-enriched atypical kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400039,"[""Latrophilin receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400039,,,,,,,,,,,,,,,,,,,,,,,,,,,,Latrophilin receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003878,"[""BGC-823 cell""]",,Human gastric cancer cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000787,,,,,,,,Human gastric cancer cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003878,,,,,,,BrendaTissueOBO,BGC823 cell,BTO:0003878,,,,,,,,,,,,,,,,,,,BGC-823 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400102,"[""Protein kinase gene""]",,A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation).,false,,,http://www.drugtargetontology.org/dto/DTO_03400101,,,,,,,,A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400102,,,,,,,,,,,,,,,,,,,,,,,,,,,https://en.wikipedia.org/wiki/Protein_kinase,Protein kinase gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200258,"[""GRIN2B gene""]",,"N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400456,,,,,,,,"N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200258,,,,,,,,,,,,,,,,2904,GRIN2B,NMDAR2B,,,,,,,,,,GRIN2B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000131,"[""blood plasma""]",,The fluid portion of the blood in which the particulate components are suspended.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,,The fluid portion of the blood in which the particulate components are suspended.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000131,,,,,,,BrendaTissueOBO,plasma,BTO:0000131,,,,,,,,,,,,,,,,,,,blood plasma,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200065,"[""CLCA1 gene""]",,"This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400339,,,,,,,,"This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200065,,,,,,,,,,,,,,,,1179,CLCA1,CACC1,,,,,,,,,,CLCA1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100055,"[""C-C chemokine receptor type 3""]",,"A C-C chemokine receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51677] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300095,,,,,,,,"A C-C chemokine receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51677] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100055,,,,https://pharos.nih.gov/idg/targets/P51677,,,,,,,,,,,,,CCR3,CMKBR3,,P51677,,,,,,,,C-C chemokine receptor type 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200686,"[""OR8B2 gene""]",,"An olfactory receptor 8B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 8B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200686,,,,,,,,,,,,,,,,26595,OR8B2,,,,,,,,,,,OR8B2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491037,"[""RIO1 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400217,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491037,,,,,,,,,,,,,,,,,,,,,,,,,,,,RIO1 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100500,"[""Olfactory receptor 1L8""]",,"An olfactory receptor 1L8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1L8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100500,,,,https://pharos.nih.gov/idg/targets/Q8NGR8,,,,,,,,,,,,,OR1L8,,,Q8NGR8,,,,,,,,Olfactory receptor 1L8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200055,"[""CACNG1 gene""]",,"Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is part of skeletal muscle 1,4-dihydropyridine-sensitive calcium channels and is an integral membrane protein that plays a role in excitation-contraction coupling. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA receptor regulatory proteins (TARPs). [provided by RefSeq, Dec 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400336,,,,,,,,"Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is part of skeletal muscle 1,4-dihydropyridine-sensitive calcium channels and is an integral membrane protein that plays a role in excitation-contraction coupling. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA receptor regulatory proteins (TARPs). [provided by RefSeq, Dec 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200055,,,,,,,,,,,,,,,,786,CACNG1,CACNLG,,,,,,,,,,CACNG1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001614,"[""colorectal cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001614,,,,,,,BrendaTissueOBO,,BTO:0001614,,,,,,,,,,,,,,,,,,,colorectal cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100305,"[""Amiloride-sensitive sodium channel subunit delta""]",,"An amiloride-sensitive sodium channel subunit delta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51172] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300479,,,,,,,,"An amiloride-sensitive sodium channel subunit delta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51172] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100305,,,,https://pharos.nih.gov/idg/targets/P51172,,,,,,,,,,,,,SCNN1D,DNACH,,P51172,,,,,,,,Amiloride-sensitive sodium channel subunit delta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200304,"[""OR10G7 gene""]",,"An olfactory receptor 10G7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10G7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200304,,,,,,,,,,,,,,,,390265,OR10G7,,,,,,,,,,,OR10G7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000180,"[""GSK3A kinase domain""]",,Glycogen synthase kinase 3 alpha; DKFZp686D0638; GSK3A; GSK3alpha; GSK3-alpha,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Glycogen synthase kinase 3 alpha; DKFZp686D0638; GSK3A; GSK3alpha; GSK3-alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000180,,,,,,,,,,,,,,,,,,,200183,,,,,,,,,GSK3A kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400133,"[""TEC family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400133,,,,,,,,,,,,,,,,,,,,,,,,,,,,TEC family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391033,"[""CDK10 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300136,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391033,,,,,,,,,,,,,,,,,,,,,,,,,,,,CDK10 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200251,"[""MAS1 gene""]",,"A G-protein coupled receptor MAS that is encoded in the genome of human. [PRO:WCB, UniProtKB:P04201] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400063,,,,,,,,"A G-protein coupled receptor MAS that is encoded in the genome of human. [PRO:WCB, UniProtKB:P04201] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200251,,,,,,,,,,,,,,,,4142,MAS1,MAS,,,,,,,,,,MAS1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9352,"[""type 2 diabetes mellitus""]",,A diabetes mellitus that involves high blood glucose resulting from cells fail to use insulin properly.,false,,,http://purl.obolibrary.org/obo/DOID_9351,,,,,,,,A diabetes mellitus that involves high blood glucose resulting from cells fail to use insulin properly.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9352,,,,NCI:C26747|KEGG:04930|SNOMEDCT_US_2016_03_01:190384004|MESH:D003924|OMIM:601407|SNOMEDCT_US_2016_03_01:154672006|OMIM:601283|OMIM:125853|OMIM:603694|EFO:0001360|ICD10CM:E11|SNOMEDCT_US_2016_03_01:267468009|SNOMEDCT_US_2016_03_01:44054006|UMLS_CUI:C0011860|OMIM:608036|SNOMEDCT_US_2016_03_01:190323008,non-insulin-dependent diabetes mellitus|type II diabetes mellitus|NIDDM,,disease_ontology,,DOID:9352,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,type 2 diabetes mellitus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100159,"[""Glycerol kinase 2""]",,"A glycerol kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14410] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391021,,,,,,,,"A glycerol kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14410] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100159,,,,https://pharos.nih.gov/idg/targets/Q14410,,,,,,,,,,,,,GK2,GKP2|GKTA,,Q14410,,,,,,,,Glycerol kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200001,"[""HTR3A gene""]",,"The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01409932,,,,,,,,"The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200001,,,,,,,,,,,,,,,,3359,HTR3A,5HT3R|HTR3,,,,,,,,,,HTR3A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001093,"[""WEHI-231 cell""]",,"Mouse, BALB/cxNZB F1, lymphoblastic lymphoma cell line. Morphology: Lymphoblast Mouse B cell lymphoma.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001518,,,,,,,,"Mouse, BALB/cxNZB F1, lymphoblastic lymphoma cell line. Morphology: Lymphoblast Mouse B cell lymphoma.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001093,,,,,,,BrendaTissueOBO,,BTO:0001093,,,,,,,,,,,,,,,,,,,WEHI-231 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200204,"[""PRKACA gene""]",,"cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400169,,,,,,,,"cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200204,,,,,,,,,,,,,,,,5566,PRKACA,PKACA,,,,,,,,,,PRKACA gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100116,"[""Galanin receptor type 2""]",,"A galanin receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O43603] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300046,,,,,,,,"A galanin receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O43603] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100116,,,,https://pharos.nih.gov/idg/targets/O43603,,,,,,,,,,,,,GALR2,GALNR2,,O43603,,,,,,,,Galanin receptor type 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100302,"[""Serine/threonine-protein kinase mark1""]",,"A serine/threonine-protein kinase MARK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P0L2] |serine/threonine-protein kinase mark1 (MARK1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300290,,,,,,,,"A serine/threonine-protein kinase MARK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P0L2] |serine/threonine-protein kinase mark1 (MARK1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100302,,,,https://pharos.nih.gov/idg/targets/Q9P0L2,,,,,,,,,,,,,MARK1,KIAA1477|MARK,,Q9P0L2,,,,,,,,Serine/threonine-protein kinase mark1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100024,"[""Muscarinic acetylcholine receptor m4""]",,"A muscarinic acetylcholine receptor M4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08173] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300020,,,,,,,,"A muscarinic acetylcholine receptor M4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08173] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100024,,,,https://pharos.nih.gov/idg/targets/P08173,,,,,,,,,,,,,CHRM4,,,P08173,,,,,,,,Muscarinic acetylcholine receptor m4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200087,"[""CLK2 gene""]",,"This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400140,,,,,,,,"This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200087,,,,,,,,,,,,,,,,1196,CLK2,,,,,,,,,,,CLK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000074,"[""LEU530 in KGP2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000074,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU530 in KGP2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6239,"[""non-invasive bladder papillary urothelial neoplasm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5432,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6239,,,DOID:6238,NCI:C27884|UMLS_CUI:C1518358|NCI:C39831|UMLS_CUI:C1266010|SNOMEDCT_US_2016_03_01:128625004,bladder papillary neoplasm of low malignant potential|bladder PUNLMP|Papillary urothelial neoplasm of low malignant potential,,disease_ontology,,DOID:6239,,,,,,,,,,,,,,,,,,,non-invasive bladder papillary urothelial neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4645,"[""retinal cancer""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5679|http://purl.obolibrary.org/obo/DOID_2174,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4645,,,DOID:770,SNOMEDCT_US_2016_03_01:127002001|SNOMEDCT_US_2016_03_01:93987004|UMLS_CUI:C0524801|NCI:C3216|ICD10CM:C69.2|ICD9CM:190.5|UMLS_CUI:C0024622|SNOMEDCT_US_2016_03_01:363465007|NCI:C4800|MESH:D019572,Retinal tumor|malignant Retinal neoplasm|neoplasm of retina|malignant neoplasm of retina|malignant tumor of retina (disorder),,disease_ontology,,DOID:4645,,,,,,,,,,,,,,,,,,,retinal cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1307,"[""dementia""]",,"A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior.",false,,,http://purl.obolibrary.org/obo/DOID_1561,,,,,,,,"A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1307,,,,UMLS_CUI:C0154319|ICD9CM:290.8,,,disease_ontology,,DOID:1307,,,,,,,,,,,,,,,,,,,dementia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200143,"[""GPR133 gene""]",,"A G-protein coupled receptor 133 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6QNK2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,"A G-protein coupled receptor 133 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6QNK2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200143,,,,,,,,,,,,,,,,283383,GPR133,PGR25,,,,,,,,,,GPR133 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000353,"[""lung cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000353,,,,,,,BrendaTissueOBO,,BTO:0000353,,,,,,,,,,,,,,,,,,,lung cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1785,"[""pituitary cancer""]",,An endocrine gland cancer located_in the pituitary gland located at the base of the brain.,false,,,http://purl.obolibrary.org/obo/DOID_53|http://purl.obolibrary.org/obo/DOID_170,,,,,,,,An endocrine gland cancer located_in the pituitary gland located at the base of the brain.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1785,,,DOID:5671,SNOMEDCT_US_2016_03_01:93964007|SNOMEDCT_US_2016_03_01:363482009|MESH:D010911|NCI:C3330|NCI:C4769|SNOMEDCT_US_2016_03_01:127024001|ICD10CM:C75.1|UMLS_CUI:C0496842|UMLS_CUI:C0032019,pituitary gland cancer|neoplasm of pituitary gland (disorder)|malignant tumor of pituitary gland (disorder)|pituitary neoplasm|Pituitary gland neoplasm|malignant Pituitary neoplasm,,disease_ontology,,DOID:1785,,,,,,,,,,,,,,,,,,,pituitary cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200167,"[""GUCY2D gene""]",,"This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq, Dec 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400125,,,,,,,,"This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq, Dec 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200167,,,,,,,,,,,,,,,,3000,GUCY2D,CORD6|GUC1A4|GUC2D,,,,,,,,,,GUCY2D gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200761,"[""RXFP1 gene""]",,"A relaxin receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HBX9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A relaxin receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HBX9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200761,,,,,,,,,,,,,,,,59350,RXFP1,LGR7,,,,,,,,,,RXFP1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000174,"[""Dynorphin A-(1-8)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000174,,,,,,,,,,,,,,,,,,,,,,,,,,,,Dynorphin A-(1-8),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2921,"[""glomerulonephritis""]",,A nephritis that causes inflammation of the glomeruli located_in kidney.,false,,,http://purl.obolibrary.org/obo/DOID_10952,,,,,,,,A nephritis that causes inflammation of the glomeruli located_in kidney.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2921,,,,UMLS_CUI:C0017658|ICD10CM:N08|MESH:D005921|SNOMEDCT_US_2016_03_01:197648001|ICD10CM:N05|SNOMEDCT_US_2016_03_01:36171008|NCI:C26784,,,disease_ontology,,DOID:2921,,,,,,,,,,,,,,,,,,,glomerulonephritis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003438,"[""WM-9 cell""]",,"Human melanoma cell line, derived from lymph node metastasis.",false,,,http://purl.obolibrary.org/obo/BTO_0000849|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Human melanoma cell line, derived from lymph node metastasis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003438,,,,,,,BrendaTissueOBO,WM9 cell,BTO:0003438,,,,,,,,,,,,,,,,,,,WM-9 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100581,"[""Fructosamine-3-kinase""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100581,,,,,,,,,,,,,,,,,FN3K,,,Q9H479,,,,,,,,Fructosamine-3-kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000184,"[""MET502 in FAK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000184,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET502 in FAK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000483,"[""frond""]",,A large leaf (especially of a palm or fern) usually with many divisions.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000713,,,,,,,,A large leaf (especially of a palm or fern) usually with many divisions.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000483,,,,,,,BrendaTissueOBO,,BTO:0000483,,,,,,,,,,,,,,,,,,,frond,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200060,"[""CACNG6 gene""]",,"Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA receptor regulatory proteins (TARPs). Alternative splicing results in multiple transcript variants. Variants in this gene have been associated with aspirin-intolerant asthma. [provided by RefSeq, Dec 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400336,,,,,,,,"Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA receptor regulatory proteins (TARPs). Alternative splicing results in multiple transcript variants. Variants in this gene have been associated with aspirin-intolerant asthma. [provided by RefSeq, Dec 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200060,,,,,,,,,,,,,,,,59285,CACNG6,,,,,,,,,,,CACNG6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200324,"[""TRPC6 gene""]",,"The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400581,,,,,,,,"The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200324,,,,,,,,,,,,,,,,7225,TRPC6,TRP6,,,,,,,,,,TRPC6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000177,"[""MET469 in DCAMKL2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000177,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET469 in DCAMKL2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300099,"[""Endothelin type B""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300038,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300099,,,,,,,,,,,,,,,,,,,,,,,,,,,,Endothelin type B,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000129,"[""EGFR(L861Q) kinase domain""]",,"Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000129,,,,,,,,,,,,,,,,,,,200131,,,,,,,,,EGFR(L861Q) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000205,"[""nerve plexus""]",,A plexus made up of intermingled nerve fibers.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A plexus made up of intermingled nerve fibers.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000205,,,,,,,BrendaTissueOBO,,BTO:0000205,,,,,,,,,,,,,,,,,,,nerve plexus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400536,"[""Kv1.5/KCNA5 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400436,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400536,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv1.5/KCNA5 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100494,"[""Serine/threonine-protein kinase 38-like""]",,"serine/threonine-protein kinase 38-like (NDR2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase 38-like that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y2H1] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300181,,,,,,,,"serine/threonine-protein kinase 38-like (NDR2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase 38-like that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y2H1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100494,,,,https://pharos.nih.gov/idg/targets/Q9Y2H1,,,,,,,,,,,,,STK38L,KIAA0965|NDR2,,Q9Y2H1,,,,,,,,Serine/threonine-protein kinase 38-like,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_10415,"[""beta-endorphin""]","
InChI=1S/C158H253N41O44S/c1-17-84(9)126(153(237)184-102(44-29-34-65-163)137(221)188-112(74-120(168)210)142(226)173-86(11)131(215)185-110(73-94-48-52-96(206)53-49-94)146(230)179-99(41-26-31-62-160)135(219)177-98(40-25-30-61-159)134(218)172-78-124(214)175-106(158(242)243)56-59-119(167)209)195-154(238)127(85(10)18-2)194-132(216)87(12)174-143(227)113(75-121(169)211)187-136(220)100(42-27-32-63-161)180-147(231)111(72-92-38-23-20-24-39-92)186-144(228)107(68-81(3)4)190-155(239)129(89(14)203)197-152(236)125(83(7)8)193-148(232)108(69-82(5)6)189-151(235)116-45-35-66-199(116)157(241)130(90(15)204)198-140(224)104(55-58-118(166)208)182-149(233)114(79-200)191-138(222)101(43-28-33-64-162)178-139(223)103(54-57-117(165)207)181-150(234)115(80-201)192-156(240)128(88(13)202)196-141(225)105(60-67-244-16)183-145(229)109(71-91-36-21-19-22-37-91)176-123(213)77-170-122(212)76-171-133(217)97(164)70-93-46-50-95(205)51-47-93/h19-24,36-39,46-53,81-90,97-116,125-130,200-206H,17-18,25-35,40-45,54-80,159-164H2,1-16H3,(H2,165,207)(H2,166,208)(H2,167,209)(H2,168,210)(H2,169,211)(H,170,212)(H,171,217)(H,172,218)(H,173,226)(H,174,227)(H,175,214)(H,176,213)(H,177,219)(H,178,223)(H,179,230)(H,180,231)(H,181,234)(H,182,233)(H,183,229)(H,184,237)(H,185,215)(H,186,228)(H,187,220)(H,188,221)(H,189,235)(H,190,239)(H,191,222)(H,192,240)(H,193,232)(H,194,216)(H,195,238)(H,196,225)(H,197,236)(H,198,224)(H,242,243)/t84-,85-,86-,87-,88+,89+,90+,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,125-,126-,127-,128-,129-,130-/m0/s1
|
Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu
|C158H253N41O44S|
CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O
|WOPZMFQRCBYPJU-NTXHZHDSSA-N","
A polypeptide consisting of 31 amino acid residues in the sequence Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu. It is an endogenous opioid peptide neurotransmitter found in the neurons of both the central and peripheral nervous system and results from processing of the precursor protein proopiomelanocortin (POMC).
",false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,CiteXplore:22578170|CiteXplore:22626645|CiteXplore:21044625|CiteXplore:21187108|CiteXplore:21775068|CiteXplore:22014186|CiteXplore:22101356|CiteXplore:22574561|Wikipedia:Beta-endorphin|KEGG COMPOUND:C02210|ChemIDplus:60617-12-1|CiteXplore:22080997,"
A polypeptide consisting of 31 amino acid residues in the sequence Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu. It is an endogenous opioid peptide neurotransmitter found in the neurons of both the central and peripheral nervous system and results from processing of the precursor protein proopiomelanocortin (POMC).
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,"beta-Endorphin|
L-tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-threonyl-L-seryl-L-glutaminyl-L-lysyl-L-seryl-L-glutaminyl-L-threonyl-L-prolyl-L-leucyl-L-valyl-L-threonyl-L-leucyl-L-phenylalanyl-L-lysyl-L-asparaginyl-L-alanyl-L-isoleucyl-L-isoleucyl-L-lysyl-L-asparaginyl-L-alanyl-L-tyrosyl-L-lysyl-L-lysylglycyl-L-glutamine
",,chebi_ontology,"
InChI=1S/C158H253N41O44S/c1-17-84(9)126(153(237)184-102(44-29-34-65-163)137(221)188-112(74-120(168)210)142(226)173-86(11)131(215)185-110(73-94-48-52-96(206)53-49-94)146(230)179-99(41-26-31-62-160)135(219)177-98(40-25-30-61-159)134(218)172-78-124(214)175-106(158(242)243)56-59-119(167)209)195-154(238)127(85(10)18-2)194-132(216)87(12)174-143(227)113(75-121(169)211)187-136(220)100(42-27-32-63-161)180-147(231)111(72-92-38-23-20-24-39-92)186-144(228)107(68-81(3)4)190-155(239)129(89(14)203)197-152(236)125(83(7)8)193-148(232)108(69-82(5)6)189-151(235)116-45-35-66-199(116)157(241)130(90(15)204)198-140(224)104(55-58-118(166)208)182-149(233)114(79-200)191-138(222)101(43-28-33-64-162)178-139(223)103(54-57-117(165)207)181-150(234)115(80-201)192-156(240)128(88(13)202)196-141(225)105(60-67-244-16)183-145(229)109(71-91-36-21-19-22-37-91)176-123(213)77-170-122(212)76-171-133(217)97(164)70-93-46-50-95(205)51-47-93/h19-24,36-39,46-53,81-90,97-116,125-130,200-206H,17-18,25-35,40-45,54-80,159-164H2,1-16H3,(H2,165,207)(H2,166,208)(H2,167,209)(H2,168,210)(H2,169,211)(H,170,212)(H,171,217)(H,172,218)(H,173,226)(H,174,227)(H,175,214)(H,176,213)(H,177,219)(H,178,223)(H,179,230)(H,180,231)(H,181,234)(H,182,233)(H,183,229)(H,184,237)(H,185,215)(H,186,228)(H,187,220)(H,188,221)(H,189,235)(H,190,239)(H,191,222)(H,192,240)(H,193,232)(H,194,216)(H,195,238)(H,196,225)(H,197,236)(H,198,224)(H,242,243)/t84-,85-,86-,87-,88+,89+,90+,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,125-,126-,127-,128-,129-,130-/m0/s1
|
Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu
|C158H253N41O44S|
CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O
|WOPZMFQRCBYPJU-NTXHZHDSSA-N",,,CHEBI:10415,,,,,,,,,,,,,,,,,,,,,,,CHEBI:10415,,,,,beta-endorphin|Beta-endorphin,,CHEBI:10415,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000162,"[""MET357 in PAK3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000162,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET357 in PAK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1116,"[""pertussis""]",,"A commensal bacterial infectious disease that results_in inflammation located_in respiratory tract, has_material_basis_in Bordetella pertussis, or has_material_basis_in Bordetella parapertussis, which produce toxins that paralyze the cilia of the respiratory epithelial cells. The infection is characterized by a prolonged, high-pitched, deeply indrawn breath (whoop).",false,,,http://purl.obolibrary.org/obo/DOID_0050339,,,,,,,,"A commensal bacterial infectious disease that results_in inflammation located_in respiratory tract, has_material_basis_in Bordetella pertussis, or has_material_basis_in Bordetella parapertussis, which produce toxins that paralyze the cilia of the respiratory epithelial cells. The infection is characterized by a prolonged, high-pitched, deeply indrawn breath (whoop).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1116,,,DOID:11333|DOID:11751,MESH:D014917|KEGG:05133|MESH:D001885|UMLS_CUI:C0006015|SNOMEDCT_US_2016_03_01:26484003,WC - Whooping cough|bordetella infection|whooping cough,,disease_ontology,,DOID:1116,http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease,,,,,,,,,,,,,,,,,,pertussis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11168,"[""anogenital venereal wart""]",,"A viral infectious disease that results_in infection located_in skin of vagina, cervix, uterus, anus, penis, scrotum, mouth, and throat, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during oral, genital, or anal sex with an infected partner. The infection has_symptom anogenital warts.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in infection located_in skin of vagina, cervix, uterus, anus, penis, scrotum, mouth, and throat, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during oral, genital, or anal sex with an infected partner. The infection has_symptom anogenital warts.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11168,,,DOID:7877,SNOMEDCT_US_2016_03_01:240542006|SNOMEDCT_US_2016_03_01:266113007|NCI:C4820|SNOMEDCT_US_2016_03_01:266198004|SNOMEDCT_US_2016_03_01:302812006|SNOMEDCT_US_2016_03_01:154365004|UMLS_CUI:C0009663|SNOMEDCT_US_2016_03_01:186688003|SNOMEDCT_US_2016_03_01:22020001|NCI:C2960|MESH:D003218|SNOMEDCT_US_2016_03_01:123157002|ICD10CM:A63.0|ICD9CM:078.11|UMLS_CUI:C0554632|SNOMEDCT_US_2016_03_01:154361008,Anogenital Human papilloma Virus Infectious Disease|venereal wart|Genital warts|genital wart virus infectious disease|Anogenital warts,,disease_ontology,Condyloma acuminatum,DOID:11168,http://purl.obolibrary.org/obo/doid#sexually_transmitted_infectious_disease,,,,,,,,,,,,,,,,,,anogenital venereal wart,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11162,"[""respiratory failure""]",,A lung disease characterized by inadequate gas exchange by the respiratory system.,false,,,http://purl.obolibrary.org/obo/DOID_850,,,,,,,,A lung disease characterized by inadequate gas exchange by the respiratory system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11162,,,DOID:11391|DOID:11392|DOID:11393,UMLS_CUI:C0264490|NCI:C27043|ICD9CM:518.81|SNOMEDCT_US_2016_03_01:65710008|ICD10CM:J96.0,chronic respiratory failure|acute and chronic respiratory failure|acute-on-chronic respiratory failure|acute respiratory Failure|respiratory insufficiency/failure,,disease_ontology,,DOID:11162,,,,,,,,,,,,,,,,,,,respiratory failure,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391030,"[""Guanylate kinase family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300326,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391030,,,,,,,,,,,,,,,,,,,,,,,,,,,,Guanylate kinase family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000798,"[""BeWo cell""]",,Human placenta choriocarcinoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001575,,,,,,,,Human placenta choriocarcinoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000798,,,,,,,BrendaTissueOBO,BEWO cell,BTO:0000798,,,,,,,,,,,,,,,,,,,BeWo cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_33700,"[""proteinogenic amino-acid residue""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_24431,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:33700,,,,,,,chebi_ontology,proteinogenic amino-acid residues|canonical amino-acid residue|standard amino-acid residues|standard amino acid residues|canonical amino-acid residues|common amino acid residues,CHEBI:33700,http://purl.obolibrary.org/obo/chebi#3_STAR,,,,,,,,,,,,,,,,,,proteinogenic amino-acid residue,,,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005202,"[""bulbil""]",,"A small bulb that develops from an aerial bud. Bulbils are easily detached and function as a means of vegetative propagation. They may form from lateral buds, as in the lesser celandine (Ranunculus ficaria), or develop in place of flowers, as in many species of Allium. Certain forms of apomixis give rise to bulbils, as seen in the lesser bulbous saxifrage (Saxifraga cernua). The term is also applied to various outgrowths formed by lower plants that become detached and develop into new plants. For example, the fern Asplenium bulbiferum produces bulbils on the upper surface of its fronds and Lycopodium selago has bulbils in the axils of the uppermost leaves.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000159,,,,,,,,"A small bulb that develops from an aerial bud. Bulbils are easily detached and function as a means of vegetative propagation. They may form from lateral buds, as in the lesser celandine (Ranunculus ficaria), or develop in place of flowers, as in many species of Allium. Certain forms of apomixis give rise to bulbils, as seen in the lesser bulbous saxifrage (Saxifraga cernua). The term is also applied to various outgrowths formed by lower plants that become detached and develop into new plants. For example, the fern Asplenium bulbiferum produces bulbils on the upper surface of its fronds and Lycopodium selago has bulbils in the axils of the uppermost leaves.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005202,XPMUser,2011-09-02T08:00:18Z,,,,,BrendaTissueOBO,,BTO:0005202,,,,,,,,,,,,,,,,,,,bulbil,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100461,"[""Proto-oncogene tyrosine-protein kinase ros""]",,"proto-oncogene tyrosine-protein kinase ros (ROS1)  with  no mutation  in a nonphosphorylated state|A proto-oncogene tyrosine-protein kinase ROS that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08922] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300220,,,,,,,,"proto-oncogene tyrosine-protein kinase ros (ROS1)  with  no mutation  in a nonphosphorylated state|A proto-oncogene tyrosine-protein kinase ROS that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08922] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100461,,,,https://pharos.nih.gov/idg/targets/P08922,,,,,,,,,,,,,ROS1,MCF3|ROS,,P08922,,,,,,,,Proto-oncogene tyrosine-protein kinase ros,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391031,"[""PI3K p85 subunit family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300323,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391031,,,,,,,,,,,,,,,,,,,,,,,,,,,,PI3K p85 subunit family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100009,"[""Neuronal acetylcholine receptor subunit alpha-4""]",,"A neuronal acetylcholine receptor subunit alpha-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P43681] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300493,,,,,,,,"A neuronal acetylcholine receptor subunit alpha-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P43681] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100009,,,,https://pharos.nih.gov/idg/targets/P43681,,,,,,,,,,,,,CHRNA4,NACRA4,,P43681,,,,,,,,Neuronal acetylcholine receptor subunit alpha-4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5166,"[""endometrial stromal tumor""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1380,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5166,,,,MESH:D036821|UMLS_CUI:C0334695|SNOMEDCT_US_2016_03_01:68738004|SNOMEDCT_US_2016_03_01:446887007,endometrial Stromal neoplasm|endometrial stromal tumor (morphologic abnormality),,disease_ontology,,DOID:5166,,,,,,,,,,,,,,,,,,,endometrial stromal tumor,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200423,"[""OR52I2 gene""]",,"An olfactory receptor 52I2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH67] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 52I2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH67] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200423,,,,,,,,,,,,,,,,143502,OR52I2,,,,,,,,,,,OR52I2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100081,"[""D(1a) dopamine receptor""]",,"A D(1A) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21728] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300037,,,,,,,,"A D(1A) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21728] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100081,,,,https://pharos.nih.gov/idg/targets/P21728,,,,,,,,,,,,,DRD1,,,P21728,,,,,,,,D(1a) dopamine receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100066,"[""Calcium-activated chloride channel regulator 2""]",,"A calcium-activated chloride channel regulator 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UQC9] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300339,,,,,,,,"A calcium-activated chloride channel regulator 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UQC9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100066,,,,https://pharos.nih.gov/idg/targets/Q9UQC9,,,,,,,,,,,,,CLCA2,CACC3,,Q9UQC9,,,,,,,,Calcium-activated chloride channel regulator 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100180,"[""N-arachidonyl glycine receptor""]",,"An N-arachidonyl glycine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14330] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"An N-arachidonyl glycine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14330] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100180,,,,https://pharos.nih.gov/idg/targets/Q14330,,,,,,,,,,,,,GPR18,GPCRW,,Q14330,,,,,,,,N-arachidonyl glycine receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002327,"[""stem cortex""]",,The outermost rows of cells in a cross section of the stem.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The outermost rows of cells in a cross section of the stem.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002327,,,,,,,BrendaTissueOBO,,BTO:0002327,,,,,,,,,,,,,,,,,,,stem cortex,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200631,"[""OR5K2 gene""]",,"An olfactory receptor 5K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHB8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHB8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200631,,,,,,,,,,,,,,,,402135,OR5K2,,,,,,,,,,,OR5K2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200718,"[""OR9K2 gene""]",,"An olfactory receptor 9K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 9K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200718,,,,,,,,,,,,,,,,441639,OR9K2,,,,,,,,,,,OR9K2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000195,"[""MET695 in PKN1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000195,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET695 in PKN1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100386,"[""Serine/threonine-protein kinase pak 3""]",,"A serine/threonine-protein kinase PAK 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75914] |serine/threonine-protein kinase pak 3 (PAK3)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300303,,,,,,,,"A serine/threonine-protein kinase PAK 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75914] |serine/threonine-protein kinase pak 3 (PAK3)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100386,,,,https://pharos.nih.gov/idg/targets/O75914,,,,,,,,,,,,,PAK3,OPHN3,,O75914,,,,,,,,Serine/threonine-protein kinase pak 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_561,"[""trigeminal nerve disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5656,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:561,,,,UMLS_CUI:C0029834|ICD9CM:350.8,,,disease_ontology,,DOID:561,,,,,,,,,,,,,,,,,,,trigeminal nerve disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200301,"[""OR10G3 gene""]",,"An olfactory receptor 10G3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10G3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200301,,,,,,,,,,,,,,,,26533,OR10G3,,,,,,,,,,,OR10G3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100632,"[""Olfactory receptor 5K3""]",,"An olfactory receptor 5K3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NET4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5K3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NET4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100632,,,,https://pharos.nih.gov/idg/targets/A6NET4,,,,,,,,,,,,,OR5K3,,,A6NET4,,,,,,,,Olfactory receptor 5K3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100017,"[""Uncharacterized aarf domain-containing protein kinase 5""]",,"An uncharacterized aarF domain-containing protein kinase 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q3MIX3] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300247,,,,,,,,"An uncharacterized aarF domain-containing protein kinase 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q3MIX3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100017,,,,https://pharos.nih.gov/idg/targets/Q3MIX3,,,,,,,,,,,,,ADCK5,,,Q3MIX3,,,,,,,,Uncharacterized aarf domain-containing protein kinase 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9256,"[""colorectal cancer""]",,A large intestine cancer that is located_in the colon and/or located_in the rectum.,false,,,http://purl.obolibrary.org/obo/DOID_5672,,,,,,,,A large intestine cancer that is located_in the colon and/or located_in the rectum.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9256,,,,UMLS_CUI:C1527249|OMIM:612231|OMIM:612232|OMIM:612591|OMIM:612230|KEGG:05210|OMIM:611469|OMIM:615083|OMIM:612590|OMIM:612592|MESH:D015179|OMIM:612589|OMIM:608812|OMIM:612229|OMIM:114500,,,disease_ontology,,DOID:9256,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,colorectal cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100248,"[""Serine/threonine-protein kinase h1""]",,"A serine/threonine-protein kinase H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11801] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300177,,,,,,,,"A serine/threonine-protein kinase H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11801] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100248,,,,https://pharos.nih.gov/idg/targets/P11801,,,,,,,,,,,,,PSKH1,,,P11801,,,,,,,,Serine/threonine-protein kinase h1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300071,"[""Neuropeptide Y receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300071,,,,,,,,,,,,,,,,,,,,,,,,,,,,Neuropeptide Y receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491005,"[""Type II PI4K subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491009,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491005,,,,,,,,,,,,,,,,,,,,,,,,,,,,Type II PI4K subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005405,"[""velum""]",,"The locomotory and feeding organ, found in the larval veliger stage of bivalves.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001262,,,,,,,,"The locomotory and feeding organ, found in the larval veliger stage of bivalves.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005405,XPMUser,2012-09-04T11:53:38Z,,,,,BrendaTissueOBO,,BTO:0005405,,,,,,,,,,,,,,,,,,,velum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100545,"[""Tau-tubulin kinase 1""]",,"A tau-tubulin kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5TCY1] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300239,,,,,,,,"A tau-tubulin kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5TCY1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100545,,,,https://pharos.nih.gov/idg/targets/Q5TCY1,,,,,,,,,,,,,TTBK1,BDTK|KIAA1855,,Q5TCY1,,,,,,,,Tau-tubulin kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100374,"[""Nuak family snf1-like kinase 1""]",,"NUAK family snf1-like kinase 1 (NUAK1)  with  no mutation  in a nonphosphorylated state|A NUAK family SNF1-like kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60285] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300301,,,,,,,,"NUAK family snf1-like kinase 1 (NUAK1)  with  no mutation  in a nonphosphorylated state|A NUAK family SNF1-like kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60285] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100374,,,,https://pharos.nih.gov/idg/targets/O60285,,,,,,,,,,,,,NUAK1,ARK5|KIAA0537|OMPHK1,,O60285,,,,,,,,Nuak family snf1-like kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100318,"[""Olfactory receptor 10k2""]",,"An olfactory receptor 10K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF99] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF99] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100318,,,,https://pharos.nih.gov/idg/targets/Q6IF99,,,,,,,,,,,,,OR10K2,,,Q6IF99,,,,,,,,Olfactory receptor 10k2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100562,"[""Serine/threonine-protein kinase vrk1""]",,"A serine/threonine-protein kinase VRK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99986] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300243,,,,,,,,"A serine/threonine-protein kinase VRK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99986] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100562,,,,https://pharos.nih.gov/idg/targets/Q99986,,,,,,,,,,,,,VRK1,,,Q99986,,,,,,,,Serine/threonine-protein kinase vrk1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000352,"[""THR361 in ABL2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000352,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR361 in ABL2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100570,"[""Serine/threonine-protein kinase wnk4""]",,"A serine/threonine-protein kinase WNK4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96J92] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300244,,,,,,,,"A serine/threonine-protein kinase WNK4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96J92] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100570,,,,https://pharos.nih.gov/idg/targets/Q96J92,,,,,,,,,,,,,WNK4,PRKWNK4,,Q96J92,,,,,,,,Serine/threonine-protein kinase wnk4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100313,"[""Olfactory receptor 10j3""]",,"An olfactory receptor 10J3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5JRS4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10J3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5JRS4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100313,,,,https://pharos.nih.gov/idg/targets/Q5JRS4,,,,,,,,,,,,,OR10J3,OR10J3P,,Q5JRS4,,,,,,,,Olfactory receptor 10j3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11705,"[""impaired renal function disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_557,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11705,,,,UMLS_CUI:C0029791|ICD9CM:588.89|ICD9CM:588.8,,,disease_ontology,,DOID:11705,,,,,,,,,,,,,,,,,,,impaired renal function disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001200,"[""aorta thoracica smooth muscle cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002195|http://purl.obolibrary.org/obo/BTO_0001964,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001200,,,,,,,BrendaTissueOBO,,BTO:0001200,,,,,,,,,,,,,,,,,,,aorta thoracica smooth muscle cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200730,"[""P2RY8 gene""]",,"A P2Y purinoceptor 8 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86VZ1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400100,,,,,,,,"A P2Y purinoceptor 8 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86VZ1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200730,,,,,,,,,,,,,,,,286530,P2RY8,,,,,,,,,,,P2RY8 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002920,"[""Y-79 cell""]",,Human retinoblastoma cell line; established from the primary tumor (right eye) of a 2-year-old Caucasian girl in 1971.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002919,,,,,,,,Human retinoblastoma cell line; established from the primary tumor (right eye) of a 2-year-old Caucasian girl in 1971.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002920,,,,,,,BrendaTissueOBO,Y79 cell,BTO:0002920,,,,,,,,,,,,,,,,,,,Y-79 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200123,"[""EFNA1 gene""]",,"This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03491040,,,,,,,,"This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200123,,,,,,,,,,,,,,,,1942,EFNA1,EPLG1|LERK1|TNFAIP4,,,,,,,,,,EFNA1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100250,"[""Pyruvate kinase pkm""]",,"A pyruvate kinase isozymes M1/M2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P14618] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300324,,,,,,,,"A pyruvate kinase isozymes M1/M2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P14618] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100250,,,,https://pharos.nih.gov/idg/targets/P14618,,,,,,,,,,,,,PKM,OIP3|PK2|PK3|PKM2,,P14618,,,,,,,,Pyruvate kinase pkm,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000169,"[""calyx""]",,The usually green outer whorl of a flower consisting of sepals.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The usually green outer whorl of a flower consisting of sepals.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000169,,,,,,,BrendaTissueOBO,,BTO:0000169,,,,,,,,,,,,,,,,,,,calyx,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000194,"[""endometrioid carcinoma cell""]",,"Ovarian carcinoma cell which resembles typical carcinoma of the endometrium and may be seen with a synchronous endometrial carcinoma. When they appear together, both tend to be of low stage.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001023,,,,,,,,"Ovarian carcinoma cell which resembles typical carcinoma of the endometrium and may be seen with a synchronous endometrial carcinoma. When they appear together, both tend to be of low stage.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000194,,,,,,,BrendaTissueOBO,,BTO:0000194,,,,,,,,,,,,,,,,,,,endometrioid carcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100482,"[""Olfactory receptor 1D4""]",,"An olfactory receptor 1D4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47884] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1D4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47884] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100482,,,,https://pharos.nih.gov/idg/targets/P47884,,,,,,,,,,,,,OR1D4,,,P47884,,,,,,,,Olfactory receptor 1D4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200157,"[""KCNJ1 gene""]",,"Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400428,,,,,,,,"Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200157,,,,,,,,,,,,,,,,3758,KCNJ1,ROMK1,,,,,,,,,,KCNJ1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200539,"[""TRPM6 gene""]",,"This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Apr 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400321,,,,,,,,"This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Apr 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200539,,,,,,,,,,,,,,,,140803,TRPM6,CHAK2,,,,,,,,,,TRPM6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11199,"[""hypoparathyroidism""]",,"A parathyroid gland disease characterized by decreased function of parathyroid glands with underproduction of parathyroid hormone (PTH), leading to abnormally low ionized calcium levels in the blood.",false,,,http://purl.obolibrary.org/obo/DOID_11201,,,,,,,,"A parathyroid gland disease characterized by decreased function of parathyroid glands with underproduction of parathyroid hormone (PTH), leading to abnormally low ionized calcium levels in the blood.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11199,,,,SNOMEDCT_US_2016_03_01:190457001|SNOMEDCT_US_2016_03_01:36976004|OMIM:146200|OMIM:307700|SNOMEDCT_US_2016_03_01:267479004|MESH:D007011|ICD9CM:252.1|ORDO:2238|ICD10CM:E20.9|ICD10CM:E20|NCI:C78350|SNOMEDCT_US_2016_03_01:154697005|UMLS_CUI:C0020626,,,disease_ontology,,DOID:11199,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,hypoparathyroidism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11193,"[""syndactyly""]",,A synostosis that results_in the fusion of two or more digits.,false,,,http://purl.obolibrary.org/obo/DOID_11971,,,,,,,,A synostosis that results_in the fusion of two or more digits.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11193,,,,ORDO:93402|ORDO:90025|SNOMEDCT_US_2016_03_01:111313001|ORDO:93403|OMIM:186100|SNOMEDCT_US_2016_03_01:205151006|ORDO:93404|ORDO:93406|SNOMEDCT_US_2016_03_01:373413006|ICD10CM:Q70.9|OMIM:186300|SNOMEDCT_US_2016_03_01:75352001|ORDO:295012|ICD9CM:755.1|SNOMEDCT_US_2016_03_01:253975004|UMLS_CUI:C0039075|ICD10CM:Q70|NCI:C87125|MESH:D013576|SNOMEDCT_US_2016_03_01:268252004|OMIM:186200|OMIM:185900|SNOMEDCT_US_2016_03_01:156989004,symphalangy|symphalangism|chromosome 2q35 duplication syndrome|webbing of digits,,disease_ontology,,DOID:11193,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,syndactyly,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300559,"[""Kv11.3/KCNH7 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300448,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300559,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv11.3/KCNH7 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200382,"[""PIK3R1 gene""]",,"Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03491031,,,,,,,,"Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200382,,,,,,,,,,,,,,,,5295,PIK3R1,GRB1,,,,,,,,,,PIK3R1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000938,"[""neuron""]",,A grayish or reddish granular cell with specialized processes that is the fundamental functional unit of nervous tissue.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A grayish or reddish granular cell with specialized processes that is the fundamental functional unit of nervous tissue.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000938,,,,,,,BrendaTissueOBO,neuronal cell|nerve cell,BTO:0000938,,,,,,,,,,,,,,,,,,,neuron,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001039,"[""peritubular cell""]",,Seminiferous tubules are made up of Sertoli cells and germ cells and they are surrounded by peritubular and myoid cells.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Seminiferous tubules are made up of Sertoli cells and germ cells and they are surrounded by peritubular and myoid cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001039,,,,,,,BrendaTissueOBO,,BTO:0001039,,,,,,,,,,,,,,,,,,,peritubular cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001230,"[""semen""]",,A viscid whitish fluid of the male reproductive tract consisting of spermatozoa suspended in secretions of accessory glands.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A viscid whitish fluid of the male reproductive tract consisting of spermatozoa suspended in secretions of accessory glands.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001230,,,,,,,BrendaTissueOBO,seminal fluid|sperm,BTO:0001230,,,,,,,,,,,,,,,,,,,semen,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001220,"[""Schwann cell""]",,Named after the German physiologist Theodor Schwann. Schwann cells are a variety of glial cell that keep peripheral nerve fibres (both myelinated and unmyelinated) alive.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Named after the German physiologist Theodor Schwann. Schwann cells are a variety of glial cell that keep peripheral nerve fibres (both myelinated and unmyelinated) alive.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001220,,,,,,,BrendaTissueOBO,neurolemmocyte,BTO:0001220,,,,,,,,,,,,,,,,,,,Schwann cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12753,"[""corneal staphyloma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_10124,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12753,,,,SNOMEDCT_US_2016_03_01:52476003|ICD10CM:H18.72|SNOMEDCT_US_2016_03_01:193849005|ICD9CM:371.73|UMLS_CUI:C0152440,,,disease_ontology,,DOID:12753,,,,,,,,,,,,,,,,,,,corneal staphyloma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000432,"[""corpus cardiacum""]",,A pair of neurohemal organs located on the walls of the aorta just behind the brain. The corpora cardiaca release their store of PTTH only after they receive a signal from neurosecretory cells in the brain.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001803,,,,,,,,A pair of neurohemal organs located on the walls of the aorta just behind the brain. The corpora cardiaca release their store of PTTH only after they receive a signal from neurosecretory cells in the brain.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000432,,,,,,,BrendaTissueOBO,corpora cardiaca,BTO:0000432,,,,,,,,,,,,,,,,,,,corpus cardiacum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200743,"[""PTGER1 gene""]",,"A prostaglandin E2 receptor EP1 subtype that is encoded in the genome of human. [PRO:WCB, UniProtKB:P34995] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A prostaglandin E2 receptor EP1 subtype that is encoded in the genome of human. [PRO:WCB, UniProtKB:P34995] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200743,,,,,,,,,,,,,,,,5731,PTGER1,,,,,,,,,,,PTGER1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200058,"[""CACNG4 gene""]",,"The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. [provided by RefSeq, Dec 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400336,,,,,,,,"The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. [provided by RefSeq, Dec 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200058,,,,,,,,,,,,,,,,27092,CACNG4,,,,,,,,,,,CACNG4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200206,"[""GPR64 gene""]",,"A G-protein coupled receptor 64 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZP9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,"A G-protein coupled receptor 64 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZP9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200206,,,,,,,,,,,,,,,,10149,GPR64,HE6|TM7LN2,,,,,,,,,,GPR64 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200416,"[""PIP5K1C gene""]",,"This locus encodes a type I phosphatidylinositol 4-phosphate 5-kinase. The encoded protein catalyzes phosphorylation of phosphatidylinositol 4-phosphate, producing phosphatidylinositol 4,5-bisphosphate. This enzyme is found at synapses and has been found to play roles in endocytosis and cell migration. Mutations at this locus have been associated with lethal congenital contractural syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Sep 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03491012,,,,,,,,"This locus encodes a type I phosphatidylinositol 4-phosphate 5-kinase. The encoded protein catalyzes phosphorylation of phosphatidylinositol 4-phosphate, producing phosphatidylinositol 4,5-bisphosphate. This enzyme is found at synapses and has been found to play roles in endocytosis and cell migration. Mutations at this locus have been associated with lethal congenital contractural syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Sep 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200416,,,,,,,,,,,,,,,,23396,PIP5K1C,KIAA0589,,,,,,,,,,PIP5K1C gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3042,"[""allergic contact dermatitis""]",,"A contact dermititis that is an allergic skin reaction to foreign chemical or substances leading to red, itchy, weepy reaction where the skin has come into contact with a substance that the immune system recognizes as foreign.",false,,,http://purl.obolibrary.org/obo/DOID_2773,,,,,,,,"A contact dermititis that is an allergic skin reaction to foreign chemical or substances leading to red, itchy, weepy reaction where the skin has come into contact with a substance that the immune system recognizes as foreign.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3042,,,,MESH:D017449|UMLS_CUI:C0162820|ICD10CM:L23|SNOMEDCT_US_2016_03_01:200841005|NCI:C26998|ICD10CM:L23.9|SNOMEDCT_US_2016_03_01:238575004,Allergic Contact Dermatitis|Allergic contact dermatitis|Allergic contact dermatitis (disorder),,disease_ontology,,DOID:3042,,,,,,,,,,,,,,,,,,,allergic contact dermatitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100285,"[""Mitogen-activated protein kinase kinase kinase 3""]",,"A mitogen-activated protein kinase kinase kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99759] |mitogen-activated protein kinase kinase kinase 3 (MAP3K3)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300186,,,,,,,,"A mitogen-activated protein kinase kinase kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99759] |mitogen-activated protein kinase kinase kinase 3 (MAP3K3)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100285,,,,https://pharos.nih.gov/idg/targets/Q99759,,,,,,,,,,,,,MAP3K3,MAPKKK3|MEKK3,,Q99759,,,,,,,,Mitogen-activated protein kinase kinase kinase 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003120,"[""atherosclerotic plaque""]",,"A buildup of cholesterol and fatty material within a blood vessel due to the effects of atherosclerosis. A fatty deposit in the intima (inner lining) of an artery, resulting from atherosclerosis.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A buildup of cholesterol and fatty material within a blood vessel due to the effects of atherosclerosis. A fatty deposit in the intima (inner lining) of an artery, resulting from atherosclerosis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003120,,,,,,,BrendaTissueOBO,atheroma cell|arterial plaque,BTO:0003120,,,,,,,,,,,,,,,,,,,atherosclerotic plaque,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1245,"[""vulva cancer""]",,,false,,,http://purl.obolibrary.org/obo/DOID_120,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1245,,,DOID:1282,ICD9CM:184.4|ICD10CM:C51|SNOMEDCT_US_2016_03_01:126922007|SNOMEDCT_US_2016_03_01:188214009|SNOMEDCT_US_2016_03_01:269604005|SNOMEDCT_US_2016_03_01:94143002|ICD10CM:C51.9|SNOMEDCT_US_2016_03_01:154535008|UMLS_CUI:C0042995|SNOMEDCT_US_2016_03_01:269471005|UMLS_CUI:C0375071|SNOMEDCT_US_2016_03_01:363367000|NCI:C7502|NCI:C3443|MESH:D014846,"malignant neoplasm of vulva unspecified|malignant tumor of vulva (disorder)|malignant Vulvar tumor|vulvar neoplasm|vulval neoplasm|vulval cancer|malignant neoplasm of vulva, unspecified|neoplasm of vulva (disorder)|Ca vulva|Vulvar tumor|malignant neoplasm of vulva unspecified (disorder)|malignant neoplasm of vulva, NOS",,disease_ontology,,DOID:1245,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,vulva cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12450,"[""pancytopenia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12450,,,,MESH:D010198|SNOMEDCT_US_2016_03_01:191250008|NCI:C34889|UMLS_CUI:C0030312|NCI:C80693|ICD10CM:D61.81|SNOMEDCT_US_2016_03_01:127034005|SNOMEDCT_US_2016_03_01:267528007|ICD9CM:284.1,,,disease_ontology,,DOID:12450,,,,,,,,,,,,,,,,,,,pancytopenia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001284,"[""femur""]",,"The bone that extends from the pelvis to the knee, being the longest and largest bone in the body; its head articulates with the acetabulum of the hip bone, and distally, the femur, along with the patella and tibia, forms the knee joint.",false,,,http://purl.obolibrary.org/obo/UBERON_0001474|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000140,,,,,,,,"The bone that extends from the pelvis to the knee, being the longest and largest bone in the body; its head articulates with the acetabulum of the hip bone, and distally, the femur, along with the patella and tibia, forms the knee joint.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001284,,,,,,,BrendaTissueOBO,os femorale|femoral bone|thigh bone|os femoris,BTO:0001284,,,,,,,,,,,,,,,,,,,femur,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004180,"[""NCCIT cell""]",,"Human pluripotent embryonal carcinoma, teratocarcinoma cell line; established in 1985 from a mediastinal mixed germ cell tumor of an adult Japanese male. This pluripotent stem cell line is capable of somatic and extraembryonic differentiation.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000306,,,,,,,,"Human pluripotent embryonal carcinoma, teratocarcinoma cell line; established in 1985 from a mediastinal mixed germ cell tumor of an adult Japanese male. This pluripotent stem cell line is capable of somatic and extraembryonic differentiation.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004180,,,,,,,BrendaTissueOBO,,BTO:0004180,,,,,,,,,,,,,,,,,,,NCCIT cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2321,"[""dyspepsia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1159,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2321,,,,MESH:D004415|SNOMEDCT_US_2016_03_01:249510006|ICD10CM:K30|SNOMEDCT_US_2016_03_01:196752002|SNOMEDCT_US_2016_03_01:87548005|UMLS_CUI:C0013395|SNOMEDCT_US_2016_03_01:155722007|SNOMEDCT_US_2016_03_01:162031009|SNOMEDCT_US_2016_03_01:266505001|SNOMEDCT_US_2016_03_01:139299007|NCI:C26756|ICD10CM:R10.13,"indigestion|Dyspepsia, indigestion NOS",,disease_ontology,,DOID:2321,,,,,,,,,,,,,,,,,,,dyspepsia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060482,"[""oculoauricular syndrome""]",,"A syndrome characterized by microcornea, microphthalmia, anterior-segment dysgenesis, cataract, coloboma of various parts of the eye, abnormalities of the retinal pigment epithelium, and rod-cone dystrophy and a particular cleft ear lobule.",false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,"A syndrome characterized by microcornea, microphthalmia, anterior-segment dysgenesis, cataract, coloboma of various parts of the eye, abnormalities of the retinal pigment epithelium, and rod-cone dystrophy and a particular cleft ear lobule.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060482,,,,MESH:C567416|OMIM:612109|ORDO:157962|ICD10CM:Q87.8,,,,,,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,oculoauricular syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060485,"[""Mowat-Wilson syndrome""]",,"A syndrome characterized by a distinct facial phenotype (high forehead, frontal bossing, large eyebrows, medially flaring and sparse in the middle part, hypertelorism, deep set but large eyes, large and uplifted ear lobes, with a central depression, saddle nose with prominent rounded nasal tip, prominent columella, open mouth, with M-shaped upper lip, frequent smiling, and a prominent but narrow and triangular pointed chin), moderate-to-severe intellectual deficiency, epilepsy and variable congenital malformations including Hirschsprung disease, genitourinary anomalies (in particular hypospadias in males), congenital heart defects, agenesis of the corpus callosum and eye anomalies. It has material basis in de novo heterozygous mutation in the ZEB2 gene on chromosome 2q22.",false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,"A syndrome characterized by a distinct facial phenotype (high forehead, frontal bossing, large eyebrows, medially flaring and sparse in the middle part, hypertelorism, deep set but large eyes, large and uplifted ear lobes, with a central depression, saddle nose with prominent rounded nasal tip, prominent columella, open mouth, with M-shaped upper lip, frequent smiling, and a prominent but narrow and triangular pointed chin), moderate-to-severe intellectual deficiency, epilepsy and variable congenital malformations including Hirschsprung disease, genitourinary anomalies (in particular hypospadias in males), congenital heart defects, agenesis of the corpus callosum and eye anomalies. It has material basis in de novo heterozygous mutation in the ZEB2 gene on chromosome 2q22.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060485,,,,SNOMEDCT_US_2016_03_01:703535000|MESH:C536990|NCI:C74999|UMLS_CUI:C1856113|ORDO:2152|OMIM:235730,"Hirschsprung disease mental retardation syndrome|microcephaly, mental retardation, and distinct facial featrues, with or without Hirschprung disease",,,,,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,Mowat-Wilson syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060488,"[""Pitt-Hopkins syndrome""]",,"A syndrome characterized by intellectual disability and developmental delay, breathing problems, recurrent seizures (epilepsy), and distinctive facial features. It has material basis in heterozygous de novo mutations in the TCF4 gene in chromosome 18q21.",false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,"A syndrome characterized by intellectual disability and developmental delay, breathing problems, recurrent seizures (epilepsy), and distinctive facial features. It has material basis in heterozygous de novo mutations in the TCF4 gene in chromosome 18q21.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060488,,,,OMIM:610954|UMLS_CUI:C1970431|SNOMEDCT_US_2016_03_01:702344008|MESH:C537403|ORDO:2896,,,,,,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,Pitt-Hopkins syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060481,"[""Goldberg-Shprintzen syndrome""]",,"A syndrome characterized by intellectual disability, specific facial gestalt and Hirschsprung's disease (HSCR). It has material basis in homozygous mutation in the KIAA1279 gene on chromosome 10q21.1.",false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,"A syndrome characterized by intellectual disability, specific facial gestalt and Hirschsprung's disease (HSCR). It has material basis in homozygous mutation in the KIAA1279 gene on chromosome 10q21.1.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060481,,,,MESH:C537279|ORDO:66629|OMIM:609460|UMLS_CUI:C1836123,Goldberg-Shprintzen megacolon syndrome,,,,,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,Goldberg-Shprintzen syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060484,"[""EAST syndrome""]",,"A syndrome characterize by seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance. It has material basis in homozygous or compound heterozygous mutation in the KCNJ10 gene on chromosome 1q23.",false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,"A syndrome characterize by seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance. It has material basis in homozygous or compound heterozygous mutation in the KCNJ10 gene on chromosome 1q23.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060484,,,,UMLS_CUI:C2748572|MESH:C557674|ORDO:199343|OMIM:612780,"SeSAME syndrome|epilepsy, ataxia, sensorineural deafness and tubulopathy|seizures, sensorineural deafness, ataxia, mental retardation and electrolyte imbalance",,,,,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,EAST syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200110,"[""FZD8 gene""]",,"A frizzled-8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H461] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400043,,,,,,,,"A frizzled-8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H461] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200110,,,,,,,,,,,,,,,,8325,FZD8,,,,,,,,,,,FZD8 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000087,"[""CCL20""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000087,,,,,,,,,,,,,,,,,,,,,,,,,,,,CCL20,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100584,"[""Olfactory receptor 4E1""]",,"An olfactory receptor 4E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C645] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C645] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100584,,,,https://pharos.nih.gov/idg/targets/P0C645,,,,,,,,,,,,,OR4E1,OR4E1P,,P0C645,,,,,,,,Olfactory receptor 4E1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9946,"[""steroid-induced glaucoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1686,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9946,,,,SNOMEDCT_US_2016_03_01:1654001|UMLS_CUI:C0339578|SNOMEDCT_US_2016_03_01:193550003|ICD9CM:365.3,Corticosteroid-induced glaucoma,,disease_ontology,,DOID:9946,,,,,,,,,,,,,,,,,,,steroid-induced glaucoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000874,"[""molting gland""]",,Either of a pair of endocrine glands located in the prothorax of certain insects and regulating molting.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001488,,,,,,,,Either of a pair of endocrine glands located in the prothorax of certain insects and regulating molting.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000874,,,,,,,BrendaTissueOBO,prothoracic gland|Y-organ,BTO:0000874,,,,,,,,,,,,,,,,,,,molting gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2747,"[""glycogen storage disease""]",,"A glycogen metabolism disorder that has_material_basis_in enzymes deficiencies necessary in the processing of glycogen synthesis or breakdown within muscles, liver, and other cell types.",false,,,http://purl.obolibrary.org/obo/DOID_0050728,,,,,,,,"A glycogen metabolism disorder that has_material_basis_in enzymes deficiencies necessary in the processing of glycogen synthesis or breakdown within muscles, liver, and other cell types.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2747,,,,SNOMEDCT_US_2016_03_01:154738008|ICD10CM:E74.0|SNOMEDCT_US_2016_03_01:190744005|ICD10CM:E74.00|UMLS_CUI:C0017919|NCI:C61272|MESH:D006008|SNOMEDCT_US_2016_03_01:29633007|SNOMEDCT_US_2016_03_01:267498002|ICD9CM:271.0,glycogenosis,glycogenoses,disease_ontology,,DOID:2747,,,,,,,,,,,,,,,,,,,glycogen storage disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000147,"[""ERBB3 kinase domain""]",,Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; HER3,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; HER3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000147,,,,,,,,,,,,,,,,,,,200149,,,,,,,,,ERBB3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400208,"[""NKF2 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400208,,,,,,,,,,,,,,,,,,,,,,,,,,,,NKF2 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001331,"[""sweat gland""]",,"A simple tubular gland of the skin that secretes perspiration, is widely distributed in nearly all parts of the human skin, and consists typically of an epithelial tube extending spirally from a minute pore on the surface of the skin into the dermis or subcutaneous tissues where it ends in a convoluted tuft.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000431|http://purl.obolibrary.org/obo/BTO_0000765,,,,,,,,"A simple tubular gland of the skin that secretes perspiration, is widely distributed in nearly all parts of the human skin, and consists typically of an epithelial tube extending spirally from a minute pore on the surface of the skin into the dermis or subcutaneous tissues where it ends in a convoluted tuft.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001331,,,,,,,BrendaTissueOBO,sudoriferous gland|glandula sudorifera|sudoriparous gland,BTO:0001331,,,,,,,,,,,,,,,,,,,sweat gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200818,"[""VIPR1 gene""]",,"A vasoactive intestinal polypeptide receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P32241] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400003,,,,,,,,"A vasoactive intestinal polypeptide receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P32241] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200818,,,,,,,,,,,,,,,,7433,VIPR1,,,,,,,,,,,VIPR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000299,"[""PHE97 in CDK8""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000299,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE97 in CDK8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004972,"[""KM-H2 cell""]",,"Human Hodgkin lymphoma cell line, established from the pleural effusion of a 37-year-old man with Hodgkin lymphoma (mixed cellularity progressing to lymphocyte depletion; stage IV at relapse) in 1974.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0004973,,,,,,,,"Human Hodgkin lymphoma cell line, established from the pleural effusion of a 37-year-old man with Hodgkin lymphoma (mixed cellularity progressing to lymphocyte depletion; stage IV at relapse) in 1974.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004972,Marion Gremse,2010-10-28T01:34:23Z,,,,,BrendaTissueOBO,KMH2 cell,BTO:0004972,,,,,,,,,,,,,,,,,,,KM-H2 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400177,"[""PSK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400177,,,,,,,,,,,,,,,,,,,,,,,,,,,,PSK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200308,"[""TMEM38B gene""]",,"This gene encodes an intracellular monovalent cation channel that functions in maintenance of intracellular calcium release. Mutations in this gene may be associated with autosomal recessive osteogenesis. [provided by RefSeq, Oct 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400371,,,,,,,,"This gene encodes an intracellular monovalent cation channel that functions in maintenance of intracellular calcium release. Mutations in this gene may be associated with autosomal recessive osteogenesis. [provided by RefSeq, Oct 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200308,,,,,,,,,,,,,,,,55151,TMEM38B,C9orf87,,,,,,,,,,TMEM38B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000255,"[""brain cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000255,,,,,,,BrendaTissueOBO,,BTO:0000255,,,,,,,,,,,,,,,,,,,brain cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10997,"[""immature cataract""]",,,false,,,http://purl.obolibrary.org/obo/DOID_9669,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10997,,,,ICD10CM:H25.09|UMLS_CUI:C0271163|SNOMEDCT_US_2016_03_01:52421005|SNOMEDCT_US_2016_03_01:193584004,Incipient cataract|Water clefts|Incipient senile cataract,,disease_ontology,,DOID:10997,,,,,,,,,,,,,,,,,,,immature cataract,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200658,"[""OR6C6 gene""]",,"An olfactory receptor 6C6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NF89] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6C6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NF89] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200658,,,,,,,,,,,,,,,,283365,OR6C6,,,,,,,,,,,OR6C6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200151,"[""KCNJ12 gene""]",,"This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400423,,,,,,,,"This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200151,,,,,,,,,,,,,,,,3768,KCNJ12,IRK2|KCNJN1,,,,,,,,,,KCNJ12 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11934,"[""head and neck cancer""]",,"An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx.",false,,,http://purl.obolibrary.org/obo/DOID_0050686,,,,,,,,"An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11934,,,,MESH:D006258|SNOMEDCT_US_2016_03_01:255055008|UMLS_CUI:C0018671|NCI:C3077,head and neck tumours|tumor of head and neck (disorder)|head and neck neoplasm|head/neck neoplasm,,disease_ontology,,DOID:11934,http://purl.obolibrary.org/obo/doid#DO_MGI_slim|http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,head and neck cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14330,"[""Parkinson's disease""]",,"A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.",false,,,http://purl.obolibrary.org/obo/DOID_0050890,,,,,,,,"A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14330,,,,MESH:D010300|OMIM:602404|UMLS_CUI:C0030567|OMIM:606852|ICD10CM:G20|SNOMEDCT_US_2016_03_01:192831003|OMIM:556500|NCI:C26845|SNOMEDCT_US_2016_03_01:154999006|ICD9CM:332.0|KEGG:05012|ORDO:2828|SNOMEDCT_US_2016_03_01:192825001|OMIM:168600|EFO:0002508|SNOMEDCT_US_2016_03_01:155000006|SNOMEDCT_US_2016_03_01:155002003|OMIM:300557|SNOMEDCT_US_2016_03_01:49049000|ICD9CM:332|OMIM:613164,paralysis agitans|Parkinson disease,,disease_ontology,,DOID:14330,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,Parkinson's disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14336,"[""estrogen excess""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1414,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14336,,,,UMLS_CUI:C0154209|SNOMEDCT_US_2016_03_01:190533004|ICD9CM:256.0|NCI:C113344|ICD10CM:E28.0|SNOMEDCT_US_2016_03_01:37295009,hyperestrogenism,,disease_ontology,,DOID:14336,,,,,,,,,,,,,,,,,,,estrogen excess,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100234,"[""Kiss-1 receptor""]",,"A KiSS-1 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q969F8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300062,,,,,,,,"A KiSS-1 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q969F8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100234,,,,https://pharos.nih.gov/idg/targets/Q969F8,,,,,,,,,,,,,KISS1R,AXOR12|GPR54,,Q969F8,,,,,,,,Kiss-1 receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100195,"[""G-protein coupled receptor 39""]",,"A G-protein coupled receptor 39 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O43194] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 39 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O43194] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100195,,,,https://pharos.nih.gov/idg/targets/O43194,,,,,,,,,,,,,GPR39,,,O43194,,,,,,,,G-protein coupled receptor 39,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002130,"[""SK-MEL cell""]",,Human metastatic melanoma cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0000849|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human metastatic melanoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002130,,,,,,,BrendaTissueOBO,,BTO:0002130,,,,,,,,,,,,,,,,,,,SK-MEL cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000279,"[""PHE79 in ICK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000279,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE79 in ICK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300039,"[""Latrophilin receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300039,,,,,,,,,,,,,,,,,,,,,,,,,,,,Latrophilin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000464,"[""YANK3 kinase domain""]",,Serine/threonine kinase 32C; MGC23665; PKE; RP11-140A10.1; STK32C; YANK3,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine kinase 32C; MGC23665; PKE; RP11-140A10.1; STK32C; YANK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000464,,,,,,,,,,,,,,,,,,,200464,,,,,,,,,YANK3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200369,"[""NRK gene""]",,"The mouse ortholog of this gene encodes a protein kinase required for JNK activation. The encoded protein may be involved in the induction of actin polymerization in late embryogenesis.[provided by RefSeq, Jun 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400187,,,,,,,,"The mouse ortholog of this gene encodes a protein kinase required for JNK activation. The encoded protein may be involved in the induction of actin polymerization in late embryogenesis.[provided by RefSeq, Jun 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200369,,,,,,,,,,,,,,,,203447,NRK,,,,,,,,,,,NRK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001273,"[""spermatheca""]",,A sac for sperm storage in the female reproductive tract of various lower animals and especially insects.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003099,,,,,,,,A sac for sperm storage in the female reproductive tract of various lower animals and especially insects.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001273,,,,,,,BrendaTissueOBO,seminal receptacle|receptaculum seminis|spermathecum,BTO:0001273,,,,,,,,,,,,,,,,,,,spermatheca,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003802,"[""macrogamete""]",,The larger and usually female gamete of a heterogamous organism.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000535,,,,,,,,The larger and usually female gamete of a heterogamous organism.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003802,,,,,,,BrendaTissueOBO,,BTO:0003802,,,,,,,,,,,,,,,,,,,macrogamete,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391020,"[""ITPK1 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300323,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391020,,,,,,,,,,,,,,,,,,,,,,,,,,,,ITPK1 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_18050,"[""L-glutamine""]","L-(+)-glutamine|L-Glutaminsaeure-5-amid|(S)-2,5-diamino-5-oxopentanoic acid|Q|GLUTAMINE|Glutamic acid 5-amide|L-Glutamin|L-glutamic acid gamma-amide|L-2-Aminoglutaramic acid|(2S)-2,5-diamino-5-oxopentanoic acid|C5H10N2O3|ZDXPYRJPNDTMRX-VKHMYHEASA-N|InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1|Glutamic acid amide|(2S)-2-amino-4-carbamoylbutanoic acid|N[C@@H](CCC(N)=O)C(O)=O|L-2-aminoglutaramic acid|Levoglutamide|146.069|0|146.14458",An optically active form of glutamine having L-configuration.,false,,,http://purl.obolibrary.org/obo/CHEBI_33709,,,,,,,CAS:56-85-9|LINCS:LSM-4741|MetaCyc:GLN|Gmelin:3509|PMID:22770225|PMID:22206385|PMID:22055478|YMDB:YMDB00002|Wikipedia:Glutamine|PMID:22575040|ECMDB:ECMDB00641|DrugBank:DB00130|Reaxys:1723797|PMID:15204730|PMID:22453904|Beilstein:1723797|KEGG:D00015|PMID:22451274|PMID:11139387|HMDB:HMDB00641|KEGG:C00064|KNApSAcK:C00001359|PDBeChem:GLN|Drug_Central:1311,An optically active form of glutamine having L-configuration.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:13110|CHEBI:6227|CHEBI:21308|CHEBI:42899|CHEBI:42812|CHEBI:42814|CHEBI:42943,,L-Glutamine|L-glutamine,,chebi_ontology,"L-(+)-glutamine|L-Glutaminsaeure-5-amid|(S)-2,5-diamino-5-oxopentanoic acid|Q|GLUTAMINE|Glutamic acid 5-amide|L-Glutamin|L-glutamic acid gamma-amide|L-2-Aminoglutaramic acid|(2S)-2,5-diamino-5-oxopentanoic acid|C5H10N2O3|ZDXPYRJPNDTMRX-VKHMYHEASA-N|InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1|Glutamic acid amide|(2S)-2-amino-4-carbamoylbutanoic acid|N[C@@H](CCC(N)=O)C(O)=O|L-2-aminoglutaramic acid|Levoglutamide|146.069|0|146.14458",,,CHEBI:18050,,,,,,,,,,,,,,,,,,,,,,,CHEBI:18050,,,,,L-glutamine,,CHEBI:18050,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000114,"[""MET129 in MARK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000114,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET129 in MARK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100603,"[""Olfactory receptor 4N5""]",,"An olfactory receptor 4N5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IXE1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4N5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IXE1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100603,,,,https://pharos.nih.gov/idg/targets/Q8IXE1,,,,,,,,,,,,,OR4N5,,,Q8IXE1,,,,,,,,Olfactory receptor 4N5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4692,"[""endophthalmitis""]",,A globe disease that is characterized by inflammation of the inside of the eye.,false,,,http://purl.obolibrary.org/obo/DOID_1242,,,,,,,,A globe disease that is characterized by inflammation of the inside of the eye.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4692,,,,SNOMEDCT_US_2016_03_01:82255004|SNOMEDCT_US_2016_03_01:128295000|MESH:D009877|NCI:C34586|SNOMEDCT_US_2016_03_01:123052006|UMLS_CUI:C0014236|SNOMEDCT_US_2016_03_01:1847009,,,disease_ontology,,DOID:4692,,,,,,,,,,,,,,,,,,,endophthalmitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100666,"[""Olfactory receptor 6N2""]",,"An olfactory receptor 6N2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6N2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100666,,,,https://pharos.nih.gov/idg/targets/Q8NGY6,,,,,,,,,,,,,OR6N2,,,Q8NGY6,,,,,,,,Olfactory receptor 6N2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100066,"[""Cadherin EGF LAG seven-pass G-type receptor 3""]",,"A cadherin EGF LAG seven-pass G-type receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYQ7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300032,,,,,,,,"A cadherin EGF LAG seven-pass G-type receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYQ7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100066,,,,https://pharos.nih.gov/idg/targets/Q9NYQ7,,,,,,,,,,,,,CELSR3,CDHF11|EGFL1|FMI1|KIAA0812|MEGF2,,Q9NYQ7,,,,,,,,Cadherin EGF LAG seven-pass G-type receptor 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300574,"[""MCOLN1 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300452,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300574,,,,,,,,,,,,,,,,,,,,,,,,,,,,MCOLN1 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000071,"[""LEU301 in CHK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000071,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU301 in CHK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004482,"[""ovarian surface epithelial cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0004129,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004482,Marion,2010-02-04T12:00:49Z,,,,,BrendaTissueOBO,OSE cell,BTO:0004482,,,,,,,,,,,,,,,,,,,ovarian surface epithelial cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100080,"[""Chloride intracellular channel protein 2""]",,"A chloride intracellular channel protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15247] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300342,,,,,,,,"A chloride intracellular channel protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15247] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100080,,,,https://pharos.nih.gov/idg/targets/O15247,,,,,,,,,,,,,CLIC2,,,O15247,,,,,,,,Chloride intracellular channel protein 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100718,"[""Olfactory receptor 9K2""]",,"An olfactory receptor 9K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 9K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100718,,,,https://pharos.nih.gov/idg/targets/Q8NGE7,,,,,,,,,,,,,OR9K2,,,Q8NGE7,,,,,,,,Olfactory receptor 9K2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3669,"[""intermittent claudication""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2349,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3669,,,,SNOMEDCT_US_2016_03_01:63491006|UMLS_CUI:C0021775|ICD10CM:I73.9|SNOMEDCT_US_2016_03_01:195312007|MESH:D007383|SNOMEDCT_US_2016_03_01:155430009,Intermittent claudication NOS|Intermittent claudication (disorder)|Charcot's syndrome|Intermittent claudication,,disease_ontology,,DOID:3669,,,,,,,,,,,,,,,,,,,intermittent claudication,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000294,"[""MRCKB kinase domain""]",,CDC42 binding protein kinase beta (DMPK-like); CDC42BPB; KIAA1124; MRCKB,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,CDC42 binding protein kinase beta (DMPK-like); CDC42BPB; KIAA1124; MRCKB,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000294,,,,,,,,,,,,,,,,,,,200271,,,,,,,,,MRCKB kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002858,"[""cerebral subcortex""]",,That part of the brain substance underlying the cerebral cortex.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,That part of the brain substance underlying the cerebral cortex.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002858,,,,,,,BrendaTissueOBO,subcortex,BTO:0002858,,,,,,,,,,,,,,,,,,,cerebral subcortex,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100378,"[""Phosphatidylinositol 4-phosphate 3-kinase c2 domain-containing subunit alpha""]",,"A phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00443] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391010,,,,,,,,"A phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00443] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100378,,,,https://pharos.nih.gov/idg/targets/O00443,,,,,,,,,,,,,PIK3C2A,,,O00443,,,,,,,,Phosphatidylinositol 4-phosphate 3-kinase c2 domain-containing subunit alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200226,"[""KCNK17 gene""]",,"The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400359,,,,,,,,"The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200226,,,,,,,,,,,,,,,,89822,KCNK17,TALK2|TASK4,,,,,,,,,,KCNK17 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002334,"[""retinal pigment epithelium cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002334,,,,,,,BrendaTissueOBO,RPE cell|RPE cell line,BTO:0002334,,,,,,,,,,,,,,,,,,,retinal pigment epithelium cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200691,"[""OR8D1 gene""]",,"An olfactory receptor 8D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZ84] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 8D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZ84] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200691,,,,,,,,,,,,,,,,283159,OR8D1,OR8D3,,,,,,,,,,OR8D1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400197,"[""NEK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400197,,,,,,,,,,,,,,,,,,,,,,,,,,,,NEK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100272,"[""Pannexin-2""]",,"A pannexin-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD6] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300365,,,,,,,,"A pannexin-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100272,,,,https://pharos.nih.gov/idg/targets/Q96RD6,,,,,,,,,,,,,PANX2,,,Q96RD6,,,,,,,,Pannexin-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100600,"[""Olfactory receptor 4M2""]",,"An olfactory receptor 4M2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4M2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100600,,,,https://pharos.nih.gov/idg/targets/Q8NGB6,,,,,,,,,,,,,OR4M2,,,Q8NGB6,,,,,,,,Olfactory receptor 4M2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200022,"[""ANO1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400329,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200022,,,,,,,,,,,,,,,,55107,ANO1,DOG1|ORAOV2|TAOS2|TMEM16A,,,,,,,,,,ANO1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200256,"[""RPS6KA6 gene""]",,"This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400280,,,,,,,,"This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200256,,,,,,,,,,,,,,,,27330,RPS6KA6,RSK4,,,,,,,,,,RPS6KA6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000062,"[""CAMK1G kinase domain""]",,Calcium/calmodulin-dependent protein kinase IG; CAMK1G; CLICKIII; dJ272L16.1; VWS1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Calcium/calmodulin-dependent protein kinase IG; CAMK1G; CLICKIII; dJ272L16.1; VWS1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000062,,,,,,,,,,,,,,,,,,,200062,,,,,,,,,CAMK1G kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000754,"[""lewy body""]",,Hyaline eosinophilic concentrically-laminated inclusions found in the substantia nigra and locus ceruleus of patients with Parkinsonism and Lewy body dementia.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Hyaline eosinophilic concentrically-laminated inclusions found in the substantia nigra and locus ceruleus of patients with Parkinsonism and Lewy body dementia.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000754,,,,,,,BrendaTissueOBO,,BTO:0000754,,,,,,,,,,,,,,,,,,,lewy body,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001170,"[""resting cell""]",,A cell that is not actively in the process of dividing.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002322,,,,,,,,A cell that is not actively in the process of dividing.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001170,,,,,,,BrendaTissueOBO,,BTO:0001170,,,,,,,,,,,,,,,,,,,resting cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11201,"[""parathyroid gland disease""]",,An endocrine system disease that is located_in the parathyroid gland.,false,,,http://purl.obolibrary.org/obo/DOID_28,,,,,,,,An endocrine system disease that is located_in the parathyroid gland.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11201,,,,ICD9CM:252|NCI:C26844|SNOMEDCT_US_2016_03_01:190462000|MESH:D010279|SNOMEDCT_US_2016_03_01:267478007|ICD10CM:E21.5|SNOMEDCT_US_2016_03_01:73132005|ICD9CM:252.9|UMLS_CUI:C0030517,disease of parathyroid glands,,disease_ontology,,DOID:11201,,,,,,,,,,,,,,,,,,,parathyroid gland disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11200,"[""T cell deficiency""]",,,false,,,http://purl.obolibrary.org/obo/DOID_612,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11200,,,,UMLS_CUI:C1333147|NCI:C27872,,,disease_ontology,,DOID:11200,,,,,,,,,,,,,,,,,,,T cell deficiency,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11206,"[""opioid abuse""]",,A substance abuse that involves the recurring use of opioid drugs despite negative consequences.,false,,,http://purl.obolibrary.org/obo/DOID_302,,,,,,,,A substance abuse that involves the recurring use of opioid drugs despite negative consequences.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11206,,,,SNOMEDCT_US_2016_03_01:5602001|ICD10CM:F11.1|UMLS_CUI:C0029095|ICD9CM:305.5,,,disease_ontology,,DOID:11206,,,,,,,,,,,,,,,,,,,opioid abuse,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11204,"[""allergic conjunctivitis""]",,"A chronic conjunctivitis that is an inflammation of the conjunctiva involing red, itchy, and watery eyes a resulting from an exposure to an allergen or an irritant.",false,,,http://purl.obolibrary.org/obo/DOID_2475,,,,,,,,"A chronic conjunctivitis that is an inflammation of the conjunctiva involing red, itchy, and watery eyes a resulting from an exposure to an allergen or an irritant.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11204,,,,MESH:D003233|UMLS_CUI:C0009766|SNOMEDCT_US_2016_03_01:473460002|SNOMEDCT_US_2016_03_01:231854006|SNOMEDCT_US_2016_03_01:193868008|NCI:C34506|SNOMEDCT_US_2016_03_01:155168003|SNOMEDCT_US_2016_03_01:20212001,,,disease_ontology,,DOID:11204,,,,,,,,,,,,,,,,,,,allergic conjunctivitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11202,"[""primary hyperparathyroidism""]",,Xref MGI.,false,,,http://purl.obolibrary.org/obo/DOID_13543,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11202,,,DOID:14790,UMLS_CUI:C0221002|NCI:C48280|SNOMEDCT_US_2016_03_01:36348003|UMLS_CUI:C0271846|SNOMEDCT_US_2016_03_01:190452007|ICD9CM:252.01|ORDO:99878|SNOMEDCT_US_2016_03_01:237653008|SNOMEDCT_US_2016_03_01:54920000|ICD10CM:E21.0|OMIM:600166|MESH:D049950,primary hyperparathyroidism (disorder)|familial primary hyperparathyroidism|familial benign hypercalcemia (disorder),,disease_ontology,,DOID:11202,,,,,,,,,,,,,,,,,Xref MGI.,,primary hyperparathyroidism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200299,"[""MAPKAPK2 gene""]",,"This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400289,,,,,,,,"This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200299,,,,,,,,,,,,,,,,9261,MAPKAPK2,,,,,,,,,,,MAPKAPK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11914,"[""gastroparesis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1159,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11914,,,,ICD10CM:K31.84|SNOMEDCT_US_2016_03_01:196753007|UMLS_CUI:C0152020|NCI:C80512|MESH:D018589|SNOMEDCT_US_2016_03_01:235675006|ICD9CM:536.3|SNOMEDCT_US_2016_03_01:77164002,gastric atonia|Gastroparesis syndrome|Gastroparalysis,,disease_ontology,,DOID:11914,,,,,,,,,,,,,,,,,,,gastroparesis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001431,"[""vascular smooth muscle""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001260,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001431,,,,,,,BrendaTissueOBO,,BTO:0001431,,,,,,,,,,,,,,,,,,,vascular smooth muscle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000100,"[""Glucagon-like peptide 1-(7-36) amide""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000100,,,,,,,,,,,,,,,,,,,,,,,,,,,,Glucagon-like peptide 1-(7-36) amide,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100203,"[""Kalirin""]",,"A kalirin that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60229] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300168,,,,,,,,"A kalirin that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60229] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100203,,,,https://pharos.nih.gov/idg/targets/O60229,,,,,,,,,,,,,KALRN,DUET|DUO|HAPIP|TRAD,,O60229,,,,,,,,Kalirin,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100145,"[""Protein-tyrosine kinase 2-beta""]",,"A focal adhesion kinase 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q14289] |protein-tyrosine kinase 2-beta (FAK2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300155,,,,,,,,"A focal adhesion kinase 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q14289] |protein-tyrosine kinase 2-beta (FAK2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100145,,,,https://pharos.nih.gov/idg/targets/Q14289,,,,,,,,,,,,,PTK2B,FAK2|PYK2|RAFTK,,Q14289,,,,,,,,Protein-tyrosine kinase 2-beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100668,"[""Olfactory receptor 6Q1""]",,"An olfactory receptor 6Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100668,,,,https://pharos.nih.gov/idg/targets/Q8NGQ2,,,,,,,,,,,,,OR6Q1,,,Q8NGQ2,,,,,,,,Olfactory receptor 6Q1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10686,"[""lactocele""]",,,false,,,http://purl.obolibrary.org/obo/DOID_10350,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10686,,,,NCI:C3515|SNOMEDCT_US_2016_03_01:266647006|ICD10CM:N64.89|MESH:C535998|SNOMEDCT_US_2016_03_01:155966000|UMLS_CUI:C0152243|SNOMEDCT_US_2016_03_01:42385006|ICD9CM:611.5,Galactocele,,disease_ontology,,DOID:10686,,,,,,,,,,,,,,,,,,,lactocele,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100225,"[""Metabotropic glutamate receptor 8""]",,"A metabotropic glutamate receptor 8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00222] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300059,,,,,,,,"A metabotropic glutamate receptor 8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00222] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100225,,,,https://pharos.nih.gov/idg/targets/O00222,,,,,,,,,,,,,GRM8,GPRC1H|MGLUR8,,O00222,,,,,,,,Metabotropic glutamate receptor 8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100158,"[""Inward rectifier potassium channel 2""]",,"An inward rectifier potassium channel 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P63252] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300429,,,,,,,,"An inward rectifier potassium channel 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P63252] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100158,,,,https://pharos.nih.gov/idg/targets/P63252,,,,,,,,,,,,,KCNJ2,IRK1,,P63252,,,,,,,,Inward rectifier potassium channel 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002891,"[""neural stem cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002891,,,,,,,BrendaTissueOBO,,BTO:0002891,,,,,,,,,,,,,,,,,,,neural stem cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200515,"[""OR2B6 gene""]",,"An olfactory receptor 2B6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58173] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2B6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58173] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200515,,,,,,,,,,,,,,,,26212,OR2B6,OR2B1|OR2B1P|OR2B5|OR2B6P,,,,,,,,,,OR2B6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004857,"[""ookinete""]",,A motile zygote in various protozoans (as the malaria parasite).,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000854,,,,,,,,A motile zygote in various protozoans (as the malaria parasite).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004857,XPMUser,2011-02-25T09:46:12Z,,,,,BrendaTissueOBO,,BTO:0004857,,,,,,,,,,,,,,,,,,,ookinete,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100101,"[""Follicle-stimulating hormone receptor""]",,"A follitropin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P23945] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300042,,,,,,,,"A follitropin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P23945] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100101,,,,https://pharos.nih.gov/idg/targets/P23945,,,,,,,,,,,,,FSHR,LGR1,,P23945,,,,,,,,Follicle-stimulating hormone receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100527,"[""Titin""]",,"A titin that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZ42] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300196,,,,,,,,"A titin that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZ42] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100527,,,,https://pharos.nih.gov/idg/targets/Q8WZ42,,,,,,,,,,,,,TTN,,,Q8WZ42,,,,,,,,Titin,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_7,"[""disease of anatomical entity""]",,A disease that manifests in a defined anatomical structure.,false,,,http://purl.obolibrary.org/obo/DOID_4,,,,,,,,A disease that manifests in a defined anatomical structure.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:7,,,DOID:8|DOID:2|DOID:1|DOID:5|DOID:72|DOID:71,,,,disease_ontology,,DOID:7,,,,,,,,,,,,,,,,,,,disease of anatomical entity,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4,"[""disease""]",,A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism.,false,,,http://www.w3.org/2002/07/owl#Thing,,,,,,,,A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4,,,,MESH:D004194|NCI:C2991|UMLS_CUI:C0012634|SNOMEDCT_US_2016_03_01:64572001,,,disease_ontology,,DOID:4,,,,,,,,,,,,,,,,,,,disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100625,"[""Ribokinase""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100625,,,,,,,,,,,,,,,,,RBKS,,,Q9H477,,,,,,,,Ribokinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3133,"[""acute porphyria""]",,"A porphyria that has_symptom abdominal pain, has_symptom neuropathy, has_symptom autonomic instability and has_symptom psychosis.",false,,,http://purl.obolibrary.org/obo/DOID_13268,,,,,,,,"A porphyria that has_symptom abdominal pain, has_symptom neuropathy, has_symptom autonomic instability and has_symptom psychosis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3133,,,,UMLS_CUI:C0162533|OMIM:612740|ORDO:100924|SNOMEDCT_US_2016_03_01:55056006|MESH:D017094,hepatic porphyria (disorder),,disease_ontology,,DOID:3133,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,acute porphyria,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001165,"[""renal artery""]",,"A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000671|http://purl.obolibrary.org/obo/BTO_0000573|http://purl.obolibrary.org/obo/UBERON_0002113,,,,,,,,"A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001165,,,,,,,BrendaTissueOBO,,BTO:0001165,,,,,,,,,,,,,,,,,,,renal artery,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100521,"[""Olfactory receptor 2D3""]",,"An olfactory receptor 2D3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2D3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100521,,,,https://pharos.nih.gov/idg/targets/Q8NGH3,,,,,,,,,,,,,OR2D3,,,Q8NGH3,,,,,,,,Olfactory receptor 2D3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200599,"[""CKB gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200599,,,,,,,,,,,,,,,,,,,,,,,,,,,,CKB gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02390002,"[""Lipidergic GPCR""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300001,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02390002,,,,,,,,,,,,,,,,,,,,,,,,,,,,Lipidergic GPCR,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100434,"[""Inactive serine/threonine-protein kinase plk5""]",,"An inactive serine/threonine-protein kinase PLK5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q496M5] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300308,,,,,,,,"An inactive serine/threonine-protein kinase PLK5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q496M5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100434,,,,https://pharos.nih.gov/idg/targets/Q496M5,,,,,,,,,,,,,PLK5,PLK5P,,Q496M5,,,,,,,,Inactive serine/threonine-protein kinase plk5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100026,"[""Anti-muellerian hormone type-2 receptor""]",,"An anti-Muellerian hormone type-2 receptor that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q16671] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300252,,,,,,,,"An anti-Muellerian hormone type-2 receptor that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q16671] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100026,,,,https://pharos.nih.gov/idg/targets/Q16671,,,,,,,,,,,,,AMHR2,AMHR|MISR2,,Q16671,,,,,,,,Anti-muellerian hormone type-2 receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400330,"[""Amiloride-sensitive sodium channel family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400330,,,,,,,,,,,,,,,,,,,,,,,,,,,,Amiloride-sensitive sodium channel family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_865,"[""vasculitis""]",,A vascular disease that is characterized by inflammation of the blood vessels.,false,,,http://purl.obolibrary.org/obo/DOID_178,,,,,,,,A vascular disease that is characterized by inflammation of the blood vessels.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:865,,,,MESH:D014657|SNOMEDCT_US_2016_03_01:266325003|SNOMEDCT_US_2016_03_01:31996006|UMLS_CUI:C0042384|NCI:C26912|SNOMEDCT_US_2016_03_01:195375002|SNOMEDCT_US_2016_03_01:393589007,Angiitis,,disease_ontology,,DOID:865,,,,,,,,,,,,,,,,,,,vasculitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_869,"[""cholesteatoma""]",,"A keratosis characterized_by keratinizing squamous epithelium located_in middle ear and/or mastoid, subepithelial connective tissue and by the progressive accumulation of keratin debris with or without surrounding inflammatory reaction.",false,,,http://purl.obolibrary.org/obo/DOID_161,,,,,,,,"A keratosis characterized_by keratinizing squamous epithelium located_in middle ear and/or mastoid, subepithelial connective tissue and by the progressive accumulation of keratin debris with or without surrounding inflammatory reaction.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:869,,,,UMLS_CUI:C0008373|SNOMEDCT_US_2016_03_01:194338004|SNOMEDCT_US_2016_03_01:575006|ICD10CM:H71.90|MESH:D002781|SNOMEDCT_US_2016_03_01:363668000|ICD9CM:385.30|SNOMEDCT_US_2016_03_01:155244001|ICD10CM:H71.9|SNOMEDCT_US_2016_03_01:267766007|NCI:C2944,,,disease_ontology,,DOID:869,,,,,,,,,,,,,,,,,,,cholesteatoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_863,"[""nervous system disease""]",,A disease of anatomical entity that is located_in the central nervous system or located_in the peripheral nervous system.,false,,,http://purl.obolibrary.org/obo/DOID_7,,,,,,,,A disease of anatomical entity that is located_in the central nervous system or located_in the peripheral nervous system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:863,,,,SNOMEDCT_US_2016_03_01:118940003|MESH:D009422|SNOMEDCT_US_2016_03_01:192641002|UMLS_CUI:C0027765|NCI:C26835|ICD10CM:G00-G99|SNOMEDCT_US_2016_03_01:154981003|ICD10CM:G98|ICD10CM:G98.8|SNOMEDCT_US_2016_03_01:267679005|SNOMEDCT_US_2016_03_01:286946008|SNOMEDCT_US_2016_03_01:155262005|ICD9CM:349.9,,,disease_ontology,,DOID:863,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,nervous system disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_866,"[""vein disease""]",,A vascular disease that is located_in a vein.,false,,,http://purl.obolibrary.org/obo/DOID_178,,,,,,,,A vascular disease that is located_in a vein.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:866,,,,ICD10CM:I82|ICD9CM:453|SNOMEDCT_US_2016_03_01:195435006|UMLS_CUI:C0155774,,,disease_ontology,,DOID:866,,,,,,,,,,,,,,,,,,,vein disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100516,"[""Serine/threonine-protein kinase tao3""]",,"A serine/threonine-protein kinase TAO3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H2K8] |serine/threonine-protein kinase tao3 (TAOK3)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300318,,,,,,,,"A serine/threonine-protein kinase TAO3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H2K8] |serine/threonine-protein kinase tao3 (TAOK3)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100516,,,,https://pharos.nih.gov/idg/targets/Q9H2K8,,,,,,,,,,,,,TAOK3,DPK|JIK|KDS|MAP3K18,,Q9H2K8,,,,,,,,Serine/threonine-protein kinase tao3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000042,"[""AMPK-alpha2 kinase domain""]",,"Protein kinase, AMP-activated, alpha 2 catalytic subunit; AMPK; AMPK2; AMPKa2; AMPK-alpha2; PRKAA; PRKAA2",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Protein kinase, AMP-activated, alpha 2 catalytic subunit; AMPK; AMPK2; AMPKa2; AMPK-alpha2; PRKAA; PRKAA2",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000042,,,,,,,,,,,,,,,,,,,200039,,,,,,,,,AMPK-alpha2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3481,"[""septicemic plague""]",,"A plague that results_in infection located_in vasculature where bacterial endotoxins cause coagulation, which leads to formation of tiny clots throughout the body. The infection has_symptom fever, has_symptom chills, has_symptom prostration, has_symptom abdominal pain, has_symptom shock and has_symptom bleeding into skin and other organs.",false,,,http://purl.obolibrary.org/obo/DOID_3482,,,,,,,,"A plague that results_in infection located_in vasculature where bacterial endotoxins cause coagulation, which leads to formation of tiny clots throughout the body. The infection has_symptom fever, has_symptom chills, has_symptom prostration, has_symptom abdominal pain, has_symptom shock and has_symptom bleeding into skin and other organs.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3481,,,,ICD10CM:A20.7|MESH:D010930|UMLS_CUI:C0152936|ICD9CM:020.2|SNOMEDCT_US_2016_03_01:9012003,Septicemic plague (disorder),,disease_ontology,,DOID:3481,http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease|http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,septicemic plague,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10323,"[""byssinosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_10316,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10323,,,,ICD10CM:J66.0|NCI:C84605|SNOMEDCT_US_2016_03_01:155589004|MESH:D002095|SNOMEDCT_US_2016_03_01:85761009|UMLS_CUI:C0006542|SNOMEDCT_US_2016_03_01:266400008|SNOMEDCT_US_2016_03_01:233689004,Flax-dressers' disease|Stripper's asthma|cotton mill fever,,disease_ontology,,DOID:10323,,,,,,,,,,,,,,,,,,,byssinosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2596,"[""larynx cancer""]",,A respiratory system cancer that is located_in the larynx.,false,,,http://purl.obolibrary.org/obo/DOID_0050615,,,,,,,,A respiratory system cancer that is located_in the larynx.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2596,,,,SNOMEDCT_US_2016_03_01:187851007|SNOMEDCT_US_2016_03_01:154484002|UMLS_CUI:C0007107|ICD9CM:161|MESH:D007822|NCI:C7484|ICD10CM:C32.9|SNOMEDCT_US_2016_03_01:363429002|SNOMEDCT_US_2016_03_01:269560007|ICD10CM:C32|ICD9CM:161.9|SNOMEDCT_US_2016_03_01:93859007,,,disease_ontology,,DOID:2596,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,larynx cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5340,"[""anterograde amnesia""]",,An amnestic disorder that involves the impaired or lost ability to memorize new things.,false,,,http://purl.obolibrary.org/obo/DOID_10914,,,,,,,,An amnestic disorder that involves the impaired or lost ability to memorize new things.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5340,,,,UMLS_CUI:C0233795|SNOMEDCT_US_2016_03_01:88822006|SNOMEDCT_US_2016_03_01:206789002|ICD10CM:R41.1|MESH:D020324,,,disease_ontology,,DOID:5340,,,,,,,,,,,,,,,,,,,anterograde amnesia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100422,"[""Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform""]",,"phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)  with  no mutation  in a nonphosphorylated state|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA(Q546K))  with  mutation K546 in PIK3CA(Q546K) in a nonphosphorylated state|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA(E542K))  with  mutation K542 in PIK3CA(E542K) in a nonphosphorylated state|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA(H1047L))  with  mutation L1047 in PIK3CA(H1047L) in a nonphosphorylated state|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA(I800L))  with  mutation L800 in PIK3CA(I800L) in a nonphosphorylated state|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA(H1047Y))  with  mutation Y1047 in PIK3CA(H1047Y) in a nonphosphorylated state|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA(C420R))  with  mutation R420 in PIK3CA(C420R) in a nonphosphorylated state|A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42336] |phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA(M1043I))  with  mutation I1043 in PIK3CA(M1043I) in a nonphosphorylated state|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA(E545K))  with  mutation K545 in PIK3CA(E545K) in a nonphosphorylated state|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA(E545A))  with  mutation A545 in PIK3CA(E545A) in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03391009,,,,,,,,"phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)  with  no mutation  in a nonphosphorylated state|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA(Q546K))  with  mutation K546 in PIK3CA(Q546K) in a nonphosphorylated state|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA(E542K))  with  mutation K542 in PIK3CA(E542K) in a nonphosphorylated state|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA(H1047L))  with  mutation L1047 in PIK3CA(H1047L) in a nonphosphorylated state|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA(I800L))  with  mutation L800 in PIK3CA(I800L) in a nonphosphorylated state|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA(H1047Y))  with  mutation Y1047 in PIK3CA(H1047Y) in a nonphosphorylated state|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA(C420R))  with  mutation R420 in PIK3CA(C420R) in a nonphosphorylated state|A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42336] |phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA(M1043I))  with  mutation I1043 in PIK3CA(M1043I) in a nonphosphorylated state|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA(E545K))  with  mutation K545 in PIK3CA(E545K) in a nonphosphorylated state|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA(E545A))  with  mutation A545 in PIK3CA(E545A) in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100422,,,,https://pharos.nih.gov/idg/targets/P42336,,,,,,,,,,,,,PIK3CA,,,P42336,,,,,,,,"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002449,"[""hypothalamic nucleus""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002449,,,,,,,BrendaTissueOBO,,BTO:0002449,,,,,,,,,,,,,,,,,,,hypothalamic nucleus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000589,"[""primary meristem""]",,Meristem (as procambium) derived from the apical meristem.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Meristem (as procambium) derived from the apical meristem.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000589,,,,,,,BrendaTissueOBO,,BTO:0000589,,,,,,,,,,,,,,,,,,,primary meristem,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100127,"[""Probable G-protein coupled receptor 101""]",,"A G-protein coupled receptor 101 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P66] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300095,,,,,,,,"A G-protein coupled receptor 101 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P66] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100127,,,,https://pharos.nih.gov/idg/targets/Q96P66,,,,,,,,,,,,,GPR101,,,Q96P66,,,,,,,,Probable G-protein coupled receptor 101,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000053,"[""LEU138 in RSK3(Kin.Dom.1-N-terminal)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000053,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU138 in RSK3(Kin.Dom.1-N-terminal),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000264,"[""MARK4 kinase domain""]",,MAP/microtubule affinity-regulating kinase 4; FLJ90097; KIAA1860; MARKL1; Nbla00650,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,MAP/microtubule affinity-regulating kinase 4; FLJ90097; KIAA1860; MARKL1; Nbla00650,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000264,,,,,,,,,,,,,,,,,,,200249,,,,,,,,,MARK4 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200627,"[""OR5H6 gene""]",,"An olfactory receptor 5H6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGV6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5H6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGV6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200627,,,,,,,,,,,,,,,,79295,OR5H6,,,,,,,,,,,OR5H6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000956,"[""gut epithelium""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000416,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000956,,,,,,,BrendaTissueOBO,,BTO:0000956,,,,,,,,,,,,,,,,,,,gut epithelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100399,"[""3-phosphoinositide-dependent protein kinase 1""]",,"3-phosphoinositide-dependent protein kinase 1 (PDPK1)  with  no mutation  in a nonphosphorylated state|A 3-phosphoinositide-dependent protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15530] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300307,,,,,,,,"3-phosphoinositide-dependent protein kinase 1 (PDPK1)  with  no mutation  in a nonphosphorylated state|A 3-phosphoinositide-dependent protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15530] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100399,,,,https://pharos.nih.gov/idg/targets/O15530,,,,,,,,,,,,,PDPK1,PDK1,,O15530,,,,,,,,3-phosphoinositide-dependent protein kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200616,"[""OR5B17 gene""]",,"An olfactory receptor 5B17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5B17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200616,,,,,,,,,,,,,,,,219965,OR5B17,OR5B20P,,,,,,,,,,OR5B17 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000112,"[""L-serine-O-phosphate""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_33709,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000112,,,,,,,,,,,,,,,,,,,,,,,,,,,,L-serine-O-phosphate,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000130,"[""MET148 in DMPK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000130,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET148 in DMPK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200003,"[""HTR1D gene""]",,"A 5-hydroxytryptamine receptor 1D that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28221] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402001,,,,,,,,"A 5-hydroxytryptamine receptor 1D that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28221] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200003,,,,,,,,,,,,,,,,3352,HTR1D,HTR1DA|HTRL,,,,,,,,,,HTR1D gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200064,"[""CDK18 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400256,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200064,,,,,,,,,,,,,,,,5129,CDK18,PCTAIRE3|PCTK3,,,,,,,,,,CDK18 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_321,"[""tropical spastic paraparesis""]",,"A viral infectious disease that results_in inflammation located_in spinal cord, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, and transmitted_by breast feeding. The infection has_symptom spastic weakness of both legs, has_symptom muscle stiffness, has_symptom sensory disturbance, and has_symptom spasms.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in inflammation located_in spinal cord, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, and transmitted_by breast feeding. The infection has_symptom spastic weakness of both legs, has_symptom muscle stiffness, has_symptom sensory disturbance, and has_symptom spasms.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:321,,,,SNOMEDCT_US_2016_03_01:192733005|ICD10CM:G04.1|SNOMEDCT_US_2016_03_01:45129002|UMLS_CUI:C0030481|MESH:D015493|SNOMEDCT_US_2016_03_01:714279000|OMIM:159580,Tropical spastic paralysis|Tropical spastic paraplegia|HTLV-associated myelopathy,,disease_ontology,,DOID:321,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,tropical spastic paraparesis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_326,"[""ischemia""]",,A vascular disease that is characterized by a restriction in blood supply to tissues.,false,,,http://purl.obolibrary.org/obo/DOID_178,,,,,,,,A vascular disease that is characterized by a restriction in blood supply to tissues.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:326,,,,MESH:D054058|UMLS_CUI:C0022116|MESH:D007511|SNOMEDCT_US_2016_03_01:52674009|NCI:C34738,,,disease_ontology,,DOID:326,,,,,,,,,,,,,,,,,,,ischemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100531,"[""Traf2 and nck-interacting protein kinase""]",,"A TRAF2 and NCK-interacting protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UKE5] |TRAF2 and nck-interacting protein kinase (TNIK)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300288,,,,,,,,"A TRAF2 and NCK-interacting protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UKE5] |TRAF2 and nck-interacting protein kinase (TNIK)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100531,,,,https://pharos.nih.gov/idg/targets/Q9UKE5,,,,,,,,,,,,,TNIK,KIAA0551,,Q9UKE5,,,,,,,,Traf2 and nck-interacting protein kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3616,"[""angiolipoma""]",,"A lipoma that is a painful subcutaneous nodule, having all other features of a typical lipoma.",false,,,http://purl.obolibrary.org/obo/DOID_3315,,,,,,,,"A lipoma that is a painful subcutaneous nodule, having all other features of a typical lipoma.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3616,,,,NCI:C3733|MESH:D018206|SNOMEDCT_US_2016_03_01:404057003|SNOMEDCT_US_2016_03_01:189780003|SNOMEDCT_US_2016_03_01:73219006|UMLS_CUI:C0206632,,,disease_ontology,,DOID:3616,,,,,,,,,,,,,,,,,,,angiolipoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200019,"[""ACKR3 gene""]",,"A C-X-C chemokine receptor type 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25106] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400031,,,,,,,,"A C-X-C chemokine receptor type 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25106] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200019,,,,,,,,,,,,,,,,57007,ACKR3,CMKOR1|CXCR7|GPR159|RDC1,,,,,,,,,,ACKR3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200348,"[""MYLK3 gene""]",,"Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).[supplied by OMIM, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400196,,,,,,,,"Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).[supplied by OMIM, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200348,,,,,,,,,,,,,,,,91807,MYLK3,MLCK,,,,,,,,,,MYLK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300432,"[""KCNJ5 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300432,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ5 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217543,"[""NR1H4 gene""]",,"This gene encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_00217465,,,,,,,,"This gene encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217543,,,,,,,,,,,,,,,,9971,NR1H4,BAR|FXR|HRR1,,,,,,,,,,NR1H4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004729,"[""peripheral blood lymphocyte""]",,"Peripheral blood lymphocytes are mature lymphocytes that circulate in the blood, rather than localising to organs, such as the spleen or lymph nodes. They comprise T cells, NK cells and B cells.",false,,,http://purl.obolibrary.org/obo/BTO_0000775|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001025,,,,,,,,"Peripheral blood lymphocytes are mature lymphocytes that circulate in the blood, rather than localising to organs, such as the spleen or lymph nodes. They comprise T cells, NK cells and B cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004729,mgr,2010-08-20T09:27:43Z,,,,,BrendaTissueOBO,PBL cell,BTO:0004729,,,,,,,,,,,,,,,,,,,peripheral blood lymphocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200636,"[""OR5M1 gene""]",,"An olfactory receptor 5M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200636,,,,,,,,,,,,,,,,390168,OR5M1,,,,,,,,,,,OR5M1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100533,"[""Olfactory receptor 2k2""]",,"An olfactory receptor 2K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100533,,,,https://pharos.nih.gov/idg/targets/Q8NGT1,,,,,,,,,,,,,OR2K2,OR2AR1P,,Q8NGT1,,,,,,,,Olfactory receptor 2k2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002030,"[""natural killer cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002030,,,,,,,BrendaTissueOBO,NK cell line,BTO:0002030,,,,,,,,,,,,,,,,,,,natural killer cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9063,"[""Ritter's disease""]",,"A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus Staphylococcus (S. aureus). The infection has_symptoms redness of skin, has_symptom fluid-filled blister formation, has_symptom fever and has_symptom irritability.",false,,,http://purl.obolibrary.org/obo/DOID_37|http://purl.obolibrary.org/obo/DOID_0050339,,,,,,,,"A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus Staphylococcus (S. aureus). The infection has_symptoms redness of skin, has_symptom fluid-filled blister formation, has_symptom fever and has_symptom irritability.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9063,,,,ICD9CM:695.81|UMLS_CUI:C0038165|SNOMEDCT_US_2016_03_01:200946001|SNOMEDCT_US_2016_03_01:367537006|MESH:D013206|NCI:C85077|ICD10CM:L00|SNOMEDCT_US_2016_03_01:87758007,"Staphylococcal scalded skin syndrome (disorder)|Pemphigus neonatorum|Dermatitis exfoliativa neonatorum|Scalded skin syndrome|Toxic epidermal necrolysis, subcorneal type (disorder)|Ritter disease",,disease_ontology,,DOID:9063,http://purl.obolibrary.org/obo/doid#gram-positive_bacterial_infectious_disease,,,,,,,,,,,,,,,,,,Ritter's disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3482,"[""plague""]",,"A primary bacterial infectious disease that results_in infection, located_in lymph node, located_in vasculature or located_in lungs, has_material_basis_in Yersinia pestis, which is transmitted_by oriental rat flea (Xenopsylla cheopis) infected by feeding on rodents and other mammals, transmitted_by air, transmitted_by direct contact or transmitted_by ingestion of contaminated undercooked food.",false,,,http://purl.obolibrary.org/obo/DOID_0050338,,,,,,,,"A primary bacterial infectious disease that results_in infection, located_in lymph node, located_in vasculature or located_in lungs, has_material_basis_in Yersinia pestis, which is transmitted_by oriental rat flea (Xenopsylla cheopis) infected by feeding on rodents and other mammals, transmitted_by air, transmitted_by direct contact or transmitted_by ingestion of contaminated undercooked food.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3482,,,,ICD9CM:020|SNOMEDCT_US_2016_03_01:187298009|ICD10CM:A20.9|SNOMEDCT_US_2016_03_01:58750007|SNOMEDCT_US_2016_03_01:186290009|MESH:D010930|ICD9CM:020.9|ICD10CM:A20|UMLS_CUI:C0032064|NCI:C85015,,,disease_ontology,,DOID:3482,http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease|http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,plague,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000341,"[""PIK3CA kinase domain""]",,"Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000341,,,,,,,,,,,,,,,,,,,200323,,,,,,,,,PIK3CA kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000131,"[""MET148 in DMPK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000131,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET148 in DMPK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000797,"[""colonic cancer cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000188,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000797,,,,,,,BrendaTissueOBO,colonic carcinoma cell line|colon carcinoma cell line|colon cancer cell line,BTO:0000797,,,,,,,,,,,,,,,,,,,colonic cancer cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100319,"[""Transient receptor potential cation channel subfamily a member 1""]",,"A transient receptor potential cation channel TRPA1 that is encoded in the genome of human. [PRO:HJD, UniProtKB:O75762] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300360,,,,,,,,"A transient receptor potential cation channel TRPA1 that is encoded in the genome of human. [PRO:HJD, UniProtKB:O75762] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100319,,,,https://pharos.nih.gov/idg/targets/O75762,,,,,,,,,,,,,TRPA1,ANKTM1,,O75762,,,,,,,,Transient receptor potential cation channel subfamily a member 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002608,"[""vomeronasal organ""]",,"A specialized part of the olfactory system located anteriorly in the nasal cavity within the nasal septum. Chemosensitive cells of the vomeronasal organ project via the vomeronasal nerve to the accessory olfactory bulb. The primary function of this organ appears to be in sensing pheromones which regulate reproductive and other social behaviors. While the structure has been thought absent in higher primate adults, data now suggests it may be present in adult humans.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A specialized part of the olfactory system located anteriorly in the nasal cavity within the nasal septum. Chemosensitive cells of the vomeronasal organ project via the vomeronasal nerve to the accessory olfactory bulb. The primary function of this organ appears to be in sensing pheromones which regulate reproductive and other social behaviors. While the structure has been thought absent in higher primate adults, data now suggests it may be present in adult humans.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002608,,,,,,,BrendaTissueOBO,organum vomeronasale|Jacobson's organ,BTO:0002608,,,,,,,,,,,,,,,,,,,vomeronasal organ,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200371,"[""OR2T27 gene""]",,"An olfactory receptor 2T27 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH04] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2T27 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH04] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200371,,,,,,,,,,,,,,,,403239,OR2T27,,,,,,,,,,,OR2T27 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002314,"[""satellite cell""]",,1. Glial cells that cluster about a neuron. 2. Free nuclei that accumulate around cells in certain diseases. 3. Elongated cells that are closely associated with a muscle fiber; they either are flattened against the fiber or occupy shallow depressions in its surface.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002322,,,,,,,,1. Glial cells that cluster about a neuron. 2. Free nuclei that accumulate around cells in certain diseases. 3. Elongated cells that are closely associated with a muscle fiber; they either are flattened against the fiber or occupy shallow depressions in its surface.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002314,,,,,,,BrendaTissueOBO,,BTO:0002314,,,,,,,,,,,,,,,,,,,satellite cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400156,"[""FAST family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400108,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400156,,,,,,,,,,,,,,,,,,,,,,,,,,,,FAST family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100585,"[""Glycerol kinase""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100585,,,,,,,,,,,,,,,,,GK,,,P32189,,,,,,,,Glycerol kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5568,"[""mediastinum teratoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5559|http://purl.obolibrary.org/obo/DOID_3307,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5568,,,,NCI:C6438|UMLS_CUI:C1334682,teratoma of mediastinum,,disease_ontology,,DOID:5568,,,,,,,,,,,,,,,,,,,mediastinum teratoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000114,"[""DMPK2 kinase domain""]",,CDC42 binding protein kinase gamma (DMPK-like); CDC42BPG; DMPK2; HSMDPKIN; KAPPA-200; MRCKgamma,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,CDC42 binding protein kinase gamma (DMPK-like); CDC42BPG; DMPK2; HSMDPKIN; KAPPA-200; MRCKgamma,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000114,,,,,,,,,,,,,,,,,,,200116,,,,,,,,,DMPK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003871,"[""uterine endometrial cancer cell""]",,More than 95% of uterine cancers arise in the endometrium. Endometrial cancer develops when the cells that make up the endometrium become abnormal and grow uncontrollably.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000257,,,,,,,,More than 95% of uterine cancers arise in the endometrium. Endometrial cancer develops when the cells that make up the endometrium become abnormal and grow uncontrollably.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003871,,,,,,,BrendaTissueOBO,endometrial carcinoma cell|endometrial cancer cell|uterine endometrial carcinoma cell,BTO:0003871,,,,,,,,,,,,,,,,,,,uterine endometrial cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001254,"[""sweat""]",,The fluid excreted from the sweat glands of the skin.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The fluid excreted from the sweat glands of the skin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001254,,,,,,,BrendaTissueOBO,skin exudate,BTO:0001254,,,,,,,,,,,,,,,,,,,sweat,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200116,"[""GABRD gene""]",,"Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. The GABA-A receptor is generally pentameric and there are five types of subunits: alpha, beta, gamma, delta, and rho. This gene encodes the delta subunit. Mutations in this gene have been associated with susceptibility to generalized epilepsy with febrile seizures, type 5. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400515,,,,,,,,"Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. The GABA-A receptor is generally pentameric and there are five types of subunits: alpha, beta, gamma, delta, and rho. This gene encodes the delta subunit. Mutations in this gene have been associated with susceptibility to generalized epilepsy with febrile seizures, type 5. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200116,,,,,,,,,,,,,,,,2563,GABRD,,,,,,,,,,,GABRD gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001278,"[""spike""]",,An elongated inflorescence similar to a raceme but having the flowers sessile on the main axis.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000469,,,,,,,,An elongated inflorescence similar to a raceme but having the flowers sessile on the main axis.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001278,,,,,,,BrendaTissueOBO,,BTO:0001278,,,,,,,,,,,,,,,,,,,spike,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100032,"[""Bestrophin-3""]",,"A bestrophin-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N1M1] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300331,,,,,,,,"A bestrophin-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N1M1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100032,,,,https://pharos.nih.gov/idg/targets/Q8N1M1,,,,,,,,,,,,,BEST3,VMD2L3,,Q8N1M1,,,,,,,,Bestrophin-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1564,"[""fungal infectious disease""]",,"A disease by infectious agent that results_in infection, has_material_basis_in Fungi, which pass the resistance barriers of the human or animal body.",false,,,http://purl.obolibrary.org/obo/DOID_0050117,,,,,,,,"A disease by infectious agent that results_in infection, has_material_basis_in Fungi, which pass the resistance barriers of the human or animal body.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1564,,,,NCI:C3245|ICD10CM:B35-B49|ICD9CM:110-118.99|SNOMEDCT_US_2016_03_01:154394006|ICD10CM:B49|SNOMEDCT_US_2016_03_01:187498007|SNOMEDCT_US_2016_03_01:154393000|SNOMEDCT_US_2016_03_01:3218000|UMLS_CUI:C0026946|SNOMEDCT_US_2016_03_01:266214005|SNOMEDCT_US_2016_03_01:187110007|MESH:D009181|SNOMEDCT_US_2016_03_01:187472001,mycosis,,disease_ontology,mycoses,DOID:1564,,,,,,,,,,,,,,,,,,,fungal infectious disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060309,"[""syndromic X-linked intellectual disability""]",,A syndromic intellectual characterized by an X-linked inheritance pattern.,false,,,http://purl.obolibrary.org/obo/DOID_0050888,,,,,,,,A syndromic intellectual characterized by an X-linked inheritance pattern.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060309,emitraka,2015-02-11T16:14:46Z,,OMIM:PS309510,syndromic X-linked mental retardation,,disease_ontology,,DOID:0060309,,,,,,,,,,,,,,,,,NT MGI.,,syndromic X-linked intellectual disability,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060308,"[""autosomal recessive non-syndromic intellectual disability""]",,A non-syndromic intellectual disability characterized by an autosomal recessive inheritance pattern.,false,,,http://purl.obolibrary.org/obo/DOID_0050889,,,,,,,,A non-syndromic intellectual disability characterized by an autosomal recessive inheritance pattern.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060308,emitraka,2015-02-11T10:32:11Z,,OMIM:614340|OMIM:611095|OMIM:615541|OMIM:611096|OMIM:614020|OMIM:249500|OMIM:611092|OMIM:614329|OMIM:615817|OMIM:611093|OMIM:614333|OMIM:614208|OMIM:611091|ORDO:88616|OMIM:614499|OMIM:607417|OMIM:614343|OMIM:615637|OMIM:608443|OMIM:614341|OMIM:615942|OMIM:614345|OMIM:611097|OMIM:615599|OMIM:615802|OMIM:611107|OMIM:614342|OMIM:614347|OMIM:615493|OMIM:614249|OMIM:611090|OMIM:615516|OMIM:614344|OMIM:614346,autosomal recessive mental retardation|autosomal recessive non-syndromic mental retardation,,disease_ontology,,DOID:0060308,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,NT MGI.,,autosomal recessive non-syndromic intellectual disability,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060305,"[""megalocornea""]",,A corneal disease characterized by a bilaterally enlarged corneal diameter without an increase in intraocular pressure. It has material basis in mutation in the CHRDL1 gene.,false,,,http://purl.obolibrary.org/obo/DOID_10124,,,,,,,,A corneal disease characterized by a bilaterally enlarged corneal diameter without an increase in intraocular pressure. It has material basis in mutation in the CHRDL1 gene.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060305,emitraka,2015-02-10T12:29:54Z,,ORDO:91489|SNOMEDCT_US_2016_03_01:39978004|HP:0007660|OMIM:249300|SNOMEDCT_US_2016_03_01:268158009|SNOMEDCT_US_2016_03_01:388840007|SNOMEDCT_US_2016_03_01:204118005|UMLS_CUI:C0344530|OMIM:309300|MESH:C562829|SNOMEDCT_US_2016_03_01:204119002,anterior megalophthalmos|congenital anterior megalophthalmia,,disease_ontology,,DOID:0060305,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,NT MGI.,,megalocornea,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000069,"[""Cortistatin-14""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000069,,,,,,,,,,,,,,,,,,,,,,,,,,,,Cortistatin-14,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4254,"[""osteosclerosis""]",,A bone remodeling disease that results_in abnormal elevated bone density or mass.,false,,,http://purl.obolibrary.org/obo/DOID_0080005,,,,,,,,A bone remodeling disease that results_in abnormal elevated bone density or mass.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4254,,,,UMLS_CUI:C0029464|NCI:C41236|SNOMEDCT_US_2016_03_01:49347007|MESH:D010026|ICD10CM:Q78.2,,,disease_ontology,,DOID:4254,,,,,,,,,,,,,,,,,,,osteosclerosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_36976,"[""nucleotide""]",nucleotides|a nucleotide,"
A nucleotide is a nucleoside phosphate. It is a phosphate ester that has a nucleoside moiety and has at least one phosphate moiety attached to the C-5 carbon of the ribose or deoxyribose moiety.
|A nucleotide is a nucleoside phosphate resulting from the condensation of the 3 or 5 hydroxy group of a nucleoside with phosphoric acid.",false,,,http://purl.obolibrary.org/obo/CHEBI_23367,,,,,,,KEGG:C00215|KEGG COMPOUND:C00215,"
A nucleotide is a nucleoside phosphate. It is a phosphate ester that has a nucleoside moiety and has at least one phosphate moiety attached to the C-5 carbon of the ribose or deoxyribose moiety.
|A nucleotide is a nucleoside phosphate resulting from the condensation of the 3 or 5 hydroxy group of a nucleoside with phosphoric acid.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:13663|CHEBI:7656|CHEBI:13215,,Nucleotide,,chebi_ontology,nucleotides|a nucleotide,,,CHEBI:36976,,,,,,,,,,,,,,,,,,,,,,,CHEBI:36976,,,,,Nucleotide|nucleotide,,CHEBI:36976,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000802,"[""alveolar macrophage""]",,"Macrophage found in lung and that can be obtained by lung lavage, responsible for clearance of inhaled particles and lung surfactant. Metabolism slightly different from peritoneal macrophages (more oxidative metabolism), often have multivesicular bodies that may represent residual undigested lung surfactant.",false,,,http://purl.obolibrary.org/obo/BTO_0000801|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Macrophage found in lung and that can be obtained by lung lavage, responsible for clearance of inhaled particles and lung surfactant. Metabolism slightly different from peritoneal macrophages (more oxidative metabolism), often have multivesicular bodies that may represent residual undigested lung surfactant.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000802,,,,,,,BrendaTissueOBO,dust cell|alveolar phagocyte,BTO:0000802,,,,,,,,,,,,,,,,,,,alveolar macrophage,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100417,"[""Serine/threonine-protein kinase pim-1""]",,"A proto-oncogene serine/threonine-protein kinase Pim-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11309] |serine/threonine-protein kinase pim-1 (PIM1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300207,,,,,,,,"A proto-oncogene serine/threonine-protein kinase Pim-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11309] |serine/threonine-protein kinase pim-1 (PIM1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100417,,,,https://pharos.nih.gov/idg/targets/P11309,,,,,,,,,,,,,PIM1,,,P11309,,,,,,,,Serine/threonine-protein kinase pim-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200765,"[""S1PR3 gene""]",,"A sphingosine 1-phosphate receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99500] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A sphingosine 1-phosphate receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99500] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200765,,,,,,,,,,,,,,,,1903,S1PR3,EDG3,,,,,,,,,,S1PR3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200142,"[""GPR132 gene""]",,"A G-protein coupled receptor 132 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UNW8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 132 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UNW8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200142,,,,,,,,,,,,,,,,29933,GPR132,G2A,,,,,,,,,,GPR132 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200525,"[""TIE1 gene""]",,"This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400234,,,,,,,,"This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200525,,,,,,,,,,,,,,,,7075,TIE1,TIE,,,,,,,,,,TIE1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200578,"[""IDNK gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200578,,,,,,,,,,,,,,,,,,,,,,,,,,,,IDNK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100245,"[""Adhesion G protein-coupled receptor L2""]",,"A latrophilin-2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O95490] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300039,,,,,,,,"A latrophilin-2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O95490] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100245,,,,https://pharos.nih.gov/idg/targets/O95490,,,,,,,,,,,,,LPHN2,ADGRL2|KIAA0786|LEC1|LPHH1,,O95490,,,,,,,,Adhesion G protein-coupled receptor L2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005059,"[""TZM-bl cell""]",,"TZM-bl cells are HeLa-cell derivatives that express high levels of CD4 and both co-receptors CXCR4 and CCR5, and are stably transduced carrying a LTR-driven firefly luciferase as well as a LTR-driven beta-galactosidase cassette.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"TZM-bl cells are HeLa-cell derivatives that express high levels of CD4 and both co-receptors CXCR4 and CCR5, and are stably transduced carrying a LTR-driven firefly luciferase as well as a LTR-driven beta-galactosidase cassette.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005059,XPMUser,2011-03-05T09:51:34Z,,,,,BrendaTissueOBO,,BTO:0005059,,,,,,,,,,,,,,,,,,,TZM-bl cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117495,"[""Oxysterols receptor lxr-beta""]",,"An oxysterols receptor LXR-beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P55055] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117465,,,,,,,,"An oxysterols receptor LXR-beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P55055] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117495,,,,https://pharos.nih.gov/idg/targets/P55055,,,,,,,,,,,,,NR1H2,NER,,P55055,,,,,,,,Oxysterols receptor lxr-beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000931,"[""neuroblastoma cell""]",,Malignant tumour cell derived from primitive ganglion cells. Mainly a tumour of childhood. Commonest sites are adrenal medulla and retroperitoneal tissue. The cells may partially differentiate into cells having the appearance of immature neurons.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Malignant tumour cell derived from primitive ganglion cells. Mainly a tumour of childhood. Commonest sites are adrenal medulla and retroperitoneal tissue. The cells may partially differentiate into cells having the appearance of immature neurons.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000931,,,,,,,BrendaTissueOBO,NBL cell,BTO:0000931,,,,,,,,,,,,,,,,,,,neuroblastoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100219,"[""Metabotropic glutamate receptor 2""]",,"A metabotropic glutamate receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14416] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300059,,,,,,,,"A metabotropic glutamate receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14416] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100219,,,,https://pharos.nih.gov/idg/targets/Q14416,,,,,,,,,,,,,GRM2,GPRC1B|MGLUR2,,Q14416,,,,,,,,Metabotropic glutamate receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1926,"[""Gaucher's disease""]",,"A sphingolipidosis characterized by deficiency of the enzyme glucocerebrosidase which results in the accumulation of harmful quantities of the glycolipid glucocerebroside throughout the body, especially within the bone marrow, spleen and liver.",false,,,http://purl.obolibrary.org/obo/DOID_1927,,,,,,,,"A sphingolipidosis characterized by deficiency of the enzyme glucocerebrosidase which results in the accumulation of harmful quantities of the glycolipid glucocerebroside throughout the body, especially within the bone marrow, spleen and liver.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1926,,,,SNOMEDCT_US_2016_03_01:2859005|SNOMEDCT_US_2016_03_01:180485001|SNOMEDCT_US_2016_03_01:190794006|OMIM:610539|ICD10CM:E75.22|OMIM:608013|ORDO:355|OMIM:230900|UMLS_CUI:C0017205|MESH:D005776|OMIM:231000|OMIM:230800|NCI:C61268|SNOMEDCT_US_2016_03_01:62201009,kerasin thesaurismosis|lipoid histiocytosis (kerasin type)|acid beta-glucosidase deficiency|glocucerebrosidase deficiency|Gaucher disease|glucosylceramide beta-glucosidase deficiency,,disease_ontology,,DOID:1926,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,Gaucher's disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400446,"[""F subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400446,,,,,,,,,,,,,,,,,,,,,,,,,,,,F subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100275,"[""Neuromedin-U receptor 2""]",,"A neuromedin-U receptor 2 that is encoded in the genome of human. [PRO:CNx, Reactome:REACT_27011] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300067,,,,,,,,"A neuromedin-U receptor 2 that is encoded in the genome of human. [PRO:CNx, Reactome:REACT_27011] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100275,,,,https://pharos.nih.gov/idg/targets/Q9GZQ4,,,,,,,,,,,,,NMUR2,NMU2R|TGR1,,Q9GZQ4,,,,,,,,Neuromedin-U receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003336,"[""pulmonary artery smooth muscle cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003336,,,,,,,BrendaTissueOBO,pulmonary artery smooth muscle,BTO:0003336,,,,,,,,,,,,,,,,,,,pulmonary artery smooth muscle cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000273,"[""PHE691 in FLT3(K663Q)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000273,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE691 in FLT3(K663Q),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200512,"[""OR2A7 gene""]",,"An olfactory receptor 2A7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R45] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2A7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R45] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200512,,,,,,,,,,,,,,,,102725084|401427,OR2A7,,,,,,,,,,,OR2A7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100274,"[""Piezo-type mechanosensitive ion channel component 1""]",,"A piezo-type mechanosensitive ion channel component 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92508] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300366,,,,,,,,"A piezo-type mechanosensitive ion channel component 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92508] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100274,,,,https://pharos.nih.gov/idg/targets/Q92508,,,,,,,,,,,,,PIEZO1,FAM38A|KIAA0233,,Q92508,,,,,,,,Piezo-type mechanosensitive ion channel component 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003487,"[""visceral endoderm""]",,"Visceral endoderm, a population of extraembyonic endoderm, is an extraembryonic tissue that functions in a regulatory capacity but does not contribute directly to the formation of any adult organs.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003360,,,,,,,,"Visceral endoderm, a population of extraembyonic endoderm, is an extraembryonic tissue that functions in a regulatory capacity but does not contribute directly to the formation of any adult organs.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003487,,,,,,,BrendaTissueOBO,,BTO:0003487,,,,,,,,,,,,,,,,,,,visceral endoderm,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000265,"[""PHE609 in SRPK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000265,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE609 in SRPK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300332,"[""Calcium channel auxiliary subunit 2 types 1-4 (cca-2) family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300332,,,,,,,,,,,,,,,,,,,,,,,,,,,,Calcium channel auxiliary subunit 2 types 1-4 (cca-2) family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/UBERON_0001264,"[""pancreas""]",,"An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes[GO]. The mature pancreas of higher vertebrates and mammals comprises two major functional units: the exocrine pancreas, which is responsible for the production of digestive enzymes to be secreted into the gut lumen, and the endocrine pancreas, which has its role in the synthesis of several hormones with key regulatory functions in food uptake and metabolism. The exocrine portion constitutes the majority of the mass of the pancreas, and contains only two different cell types, the secretory acinar cells and the ductular cells. The endocrine portion, which comprises only 1–2% of the total mass, contains five different cell types, which are organized into mixed functional assemblies referred to as the islets of Langerhans[PMID].",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000345|http://purl.obolibrary.org/obo/BTO_0001491|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,http://www.snomedbrowser.com/Codes/Details/181277001|http://linkedlifedata.com/resource/umls/id/C0030274|http://en.wikipedia.org/wiki/Pancreas|OpenCyc:Mx4rvVimZZwpEbGdrcN5Y29ycA|XAO:0000136|TAO:0000140|CALOHA:TS-0736|UMLS:C0030274|MAT:0000075|BTO:0000988|AAO:0010112|EMAPA:18816|VHOG:0000050|ZFA:0000140|FMA:7198|EMAPA:17503|GAID:334|MA:0000120|MIAA:0000075|ncithesaurus:Pancreas|MESH:A03.734|EFO:0000855|EHDAA2:0001367|EV:0100092|EHDAA:6893|galen:Pancreas,"An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes[GO]. The mature pancreas of higher vertebrates and mammals comprises two major functional units: the exocrine pancreas, which is responsible for the production of digestive enzymes to be secreted into the gut lumen, and the endocrine pancreas, which has its role in the synthesis of several hormones with key regulatory functions in food uptake and metabolism. The exocrine portion constitutes the majority of the mass of the pancreas, and contains only two different cell types, the secretory acinar cells and the ductular cells. The endocrine portion, which comprises only 1–2% of the total mass, contains five different cell types, which are organized into mixed functional assemblies referred to as the islets of Langerhans[PMID].",,http://upload.wikimedia.org/wikipedia/commons/thumb/3/3f/Illu_pancrease.svg/200px-Illu_pancrease.svg.png|http://upload.wikimedia.org/wikipedia/commons/3/3f/Illu_pancrease.svg,,,,,,,,Organ which secretes a fluid containing enzymes that aid in the digestion of food.[AAO],,,,,,,,,,,,,,,,,,,,,,,,,,,,uberon,,pancreatic,"In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG]",,,,,,,,,,,,,,,,,,,,,,,,UBERON:0001264,,,"taxon notes: As a secretory organ serving exocrine and endocrine functions, the pancreas is specific to the vertebrates[PMID:16417468] Hagfishes and lampreys are unique in the complete separation of their endocrine pancreas (islet or- gan) and their exocrine pancreas (50). The endocrine and exocrine pancreas are coassociated in crown gnathostomes (50). In Branchiostoma and Ciona, there is no diverticulum as there is in hagfishes, lampreys, and gnathostomes, only dispersed insulin-secreting cells in the walls of the gastrointestinal tract (51, 52) [PMID:20959416]. The zebrafish does not have a discrete pancreas. Exocrine pancreatic tissue can be found scattered along the intestinal tract (Figures 16 and 17 ). The acinar structure of the exocrine pancreas is very similar to that of mammals and comprises cells with a very dark, basophilic cytoplasm",,pancreas,,UBERON:0001264,,http://purl.obolibrary.org/obo/uberon.owl,http://purl.obolibrary.org/obo/uberon/core#efo_slim|http://purl.obolibrary.org/obo/uberon/core#organ_slim|http://purl.obolibrary.org/obo/uberon/core#vertebrate_core|http://purl.obolibrary.org/obo/uberon/core#major_organ|http://purl.obolibrary.org/obo/uberon/core#uberon_slim,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400348,"[""Fxyd family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400348,,,,,,,,,,,,,,,,,,,,,,,,,,,,Fxyd family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100338,"[""Dual specificity mitogen-activated protein kinase kinase 5""]",,"A dual specificity mitogen-activated protein kinase kinase 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13163] |dual specificity mitogen-activated protein kinase kinase 5 (MP2K5)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300194,,,,,,,,"A dual specificity mitogen-activated protein kinase kinase 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13163] |dual specificity mitogen-activated protein kinase kinase 5 (MP2K5)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100338,,,,https://pharos.nih.gov/idg/targets/Q13163,,,,,,,,,,,,,MAP2K5,MEK5|MKK5|PRKMK5,,Q13163,,,,,,,,Dual specificity mitogen-activated protein kinase kinase 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100685,"[""Olfactory receptor 8A1""]",,"An olfactory receptor 8A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 8A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100685,,,,https://pharos.nih.gov/idg/targets/Q8NGG7,,,,,,,,,,,,,OR8A1,,,Q8NGG7,,,,,,,,Olfactory receptor 8A1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3113,"[""papillary carcinoma""]",,A carcinoma that is derives_from epithelial cells with finger like projections.,false,,,http://purl.obolibrary.org/obo/DOID_305,,,,,,,,A carcinoma that is derives_from epithelial cells with finger like projections.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3113,,,,SNOMEDCT_US_2016_03_01:189562005|MESH:D002291|NCI:C2927|SNOMEDCT_US_2016_03_01:25910003|UMLS_CUI:C0007133,Papillary carcinoma NOS (morphologic abnormality)|Papillary carcinoma|Papillary carcinoma (morphologic abnormality),,disease_ontology,,DOID:3113,,,,,,,,,,,,,,,,,,,papillary carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100186,"[""Insulin receptor""]",,"An insulin receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P06213] |insulin receptor (INSR)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300163,,,,,,,,"An insulin receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P06213] |insulin receptor (INSR)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100186,,,,https://pharos.nih.gov/idg/targets/P06213,,,,,,,,,,,,,INSR,,,P06213,,,,,,,,Insulin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003192,"[""renal cancer cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003192,,,,,,,BrendaTissueOBO,kidney cancer cell line,BTO:0003192,,,,,,,,,,,,,,,,,,,renal cancer cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100522,"[""Olfactory receptor 2F1""]",,"An olfactory receptor 2F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13607] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13607] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100522,,,,https://pharos.nih.gov/idg/targets/Q13607,,,,,,,,,,,,,OR2F1,OLF3|OR2F3|OR2F3P|OR2F4|OR2F5,,Q13607,,,,,,,,Olfactory receptor 2F1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200002,"[""HTR1B gene""]",,"A 5-hydroxytryptamine receptor 1B that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28222] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402001,,,,,,,,"A 5-hydroxytryptamine receptor 1B that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28222] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200002,,,,,,,,,,,,,,,,3351,HTR1B,HTR1DB,,,,,,,,,,HTR1B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002279,"[""J-774 cell""]",,Mouse macrophage cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002278,,,,,,,,Mouse macrophage cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002279,,,,,,,BrendaTissueOBO,J774 cell,BTO:0002279,,,,,,,,,,,,,,,,,,,J-774 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200540,"[""TSSK1B gene""]",,"TSSK1 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400238,,,,,,,,"TSSK1 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200540,,,,,,,,,,,,,,,,83942,TSSK1B,SPOGA1|SPOGA4|STK22A,,,,,,,,,,TSSK1B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050557,"[""congenital muscular dystrophy""]",,"A muscular dystrophy that is characterized by diminished muscle tone (hypotonia), progressive muscle weakness and degeneration (atrophy), abnormally fixed joints, spinal rigidity, and delays in reaching motor milestones such as sitting or standing unassisted.",false,,,http://purl.obolibrary.org/obo/DOID_9884,,,,,,,,"A muscular dystrophy that is characterized by diminished muscle tone (hypotonia), progressive muscle weakness and degeneration (atrophy), abnormally fixed joints, spinal rigidity, and delays in reaching motor milestones such as sitting or standing unassisted.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050557,,,,SNOMEDCT_US_2016_03_01:193221009|SNOMEDCT_US_2016_03_01:193224001|SNOMEDCT_US_2016_03_01:111501005|ICD9CM:359.0|ORDO:97242|OMIM:254100|UMLS_CUI:C2937300,,,disease_ontology,,DOID:0050557,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,congenital muscular dystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050558,"[""Ullrich congenital muscular dystrophy""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050557,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050558,,,,OMIM:254090,ULLRICH DISEASE|Ullrich scleroatonic muscular dystrophy,,disease_ontology,,DOID:0050558,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Ullrich congenital muscular dystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000566,"[""N-oleoylethanolamide""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_32952,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000566,,,,,,,,,,,,,,,,,,,,,,,,,,,,N-oleoylethanolamide,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400417,"[""GRIK2 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400417,,,,,,,,,,,,,,,,,,,,,,,,,,,,GRIK2 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200327,"[""OR10Z1 gene""]",,"An olfactory receptor 10Z1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10Z1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200327,,,,,,,,,,,,,,,,128368,OR10Z1,,,,,,,,,,,OR10Z1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3179,"[""inverted papilloma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2615,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3179,,,,NCI:C3793|MESH:D018308|SNOMEDCT_US_2016_03_01:104081000119103|UMLS_CUI:C0206721,"Inverted papilloma|Inverted papilloma, squamous cell",,disease_ontology,,DOID:3179,,,,,,,,,,,,,,,,,,,inverted papilloma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001946,"[""myofibroblast""]",,"An atypical fibroblast combining the ultrastructural features of a fibroblast and a smooth muscle cell; it has a highly irregular nucleus, a large amount of rough endoplasmic reticulum, and a dense collection of myofilaments.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000452,,,,,,,,"An atypical fibroblast combining the ultrastructural features of a fibroblast and a smooth muscle cell; it has a highly irregular nucleus, a large amount of rough endoplasmic reticulum, and a dense collection of myofilaments.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001946,,,,,,,BrendaTissueOBO,smooth muscle-like cell,BTO:0001946,,,,,,,,,,,,,,,,,,,myofibroblast,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6225,"[""Cronkhite-Canada syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_76,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6225,,,,NCI:C7035|UMLS_CUI:C1333764,gastric Cronkhite Canada polyposis,,disease_ontology,,DOID:6225,,,,,,,,,,,,,,,,,,,Cronkhite-Canada syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400466,"[""SCN2B family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400370,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400466,,,,,,,,,,,,,,,,,,,,,,,,,,,,SCN2B family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003349,"[""microglial cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003349,,,,,,,BrendaTissueOBO,,BTO:0003349,,,,,,,,,,,,,,,,,,,microglial cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000061,"[""CAMK1D kinase domain""]",,Calcium/calmodulin-dependent protein kinase ID; CaM-K1; CAMK1D; CaMKID; CKLiK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Calcium/calmodulin-dependent protein kinase ID; CaM-K1; CAMK1D; CaMKID; CKLiK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000061,,,,,,,,,,,,,,,,,,,200061,,,,,,,,,CAMK1D kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5520,"[""head and neck squamous cell carcinoma""]",,"A head and neck carcinoma that has_material_basis_in squamous cells that line the moist, mucosal surfaces inside the head and neck.",false,,,http://purl.obolibrary.org/obo/DOID_1542|http://purl.obolibrary.org/obo/DOID_1749,,,,,,,,"A head and neck carcinoma that has_material_basis_in squamous cells that line the moist, mucosal surfaces inside the head and neck.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5520,,,,UMLS_CUI:C1168401|OMIM:275355|MESH:C535575|NCI:C34447,carcinoma of the head and neck|squamous cell carcinoma of the head and neck|squamous cell carcinomas of head and neck,,disease_ontology,,DOID:5520,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,head and neck squamous cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100134,"[""Glutamate receptor 2""]",,"A glutamate receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42262] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300411,,,,,,,,"A glutamate receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42262] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100134,,,,https://pharos.nih.gov/idg/targets/P42262,,,,,,,,,,,,,GRIA2,GLUR2,,P42262,,,,,,,,Glutamate receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000970,"[""osteosarcoma cell""]",,A cell of a sarcoma derived from bone or containing bone tissue.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001207,,,,,,,,A cell of a sarcoma derived from bone or containing bone tissue.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000970,,,,,,,BrendaTissueOBO,osteoblastic sarcoma cell|osteogenic sarcoma cell,BTO:0000970,,,,,,,,,,,,,,,,,,,osteosarcoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003320,"[""HEL-92.1.7 cell""]",,Human erythroleukemia cell line; established from a 30 years old caucasian male.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000846,,,,,,,,Human erythroleukemia cell line; established from a 30 years old caucasian male.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003320,,,,,,,BrendaTissueOBO,HEL 92.1.7 cell|HEL.92.1.7 cell|HEL92.1.7 cell|HEL (TIB-180) cell|HEL TIB 180 cell,BTO:0003320,,,,,,,,,,,,,,,,,,,HEL-92.1.7 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400176,"[""PKD family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400176,,,,,,,,,,,,,,,,,,,,,,,,,,,,PKD family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100307,"[""Trimeric intracellular cation channel type a""]",,"A trimeric intracellular cation channel type A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H6F2] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300371,,,,,,,,"A trimeric intracellular cation channel type A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H6F2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100307,,,,https://pharos.nih.gov/idg/targets/Q9H6F2,,,,,,,,,,,,,TMEM38A,,,Q9H6F2,,,,,,,,Trimeric intracellular cation channel type a,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000275,"[""colonocyte""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000275,,,,,,,BrendaTissueOBO,,BTO:0000275,,,,,,,,,,,,,,,,,,,colonocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000167,"[""adenocarcinoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000297,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000167,,,,,,,BrendaTissueOBO,,BTO:0000167,,,,,,,,,,,,,,,,,,,adenocarcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200228,"[""KCNN1 gene""]",,"Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400437,,,,,,,,"Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200228,,,,,,,,,,,,,,,,3780,KCNN1,SK,,,,,,,,,,KCNN1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200108,"[""DGKH gene""]",,"This gene encodes a member of the diacylglycerol kinase (DGK) enzyme family. Members of this family are involved in regulating intracellular concentrations of diacylglycerol and phosphatidic acid. Variation in this gene has been associated with bipolar disorder. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03491025,,,,,,,,"This gene encodes a member of the diacylglycerol kinase (DGK) enzyme family. Members of this family are involved in regulating intracellular concentrations of diacylglycerol and phosphatidic acid. Variation in this gene has been associated with bipolar disorder. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200108,,,,,,,,,,,,,,,,160851,DGKH,,,,,,,,,,,DGKH gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000529,"[""C6 glioma cell""]",,"The glial cell strain, C6, was cloned from a rat glial tumor induced by N-nitrosomethylurea by Benda et al after a series of alternate culture and animal passages. Tissue: brain; glial cell; glioma. Morphology: fibroblast.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000711,,,,,,,,"The glial cell strain, C6, was cloned from a rat glial tumor induced by N-nitrosomethylurea by Benda et al after a series of alternate culture and animal passages. Tissue: brain; glial cell; glioma. Morphology: fibroblast.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000529,,,,,,,BrendaTissueOBO,C6 cell|rat glioblastoma C6 cell,BTO:0000529,,,,,,,,,,,,,,,,,,,C6 glioma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003015,"[""macula lutea""]",,"An irregular yellowish depression on the retina, about 3 degrees wide, lateral to and slightly below the optic disk; it is the site of absorption of short wavelengths of light, and it is thought that its variation in size, shape, and coloring may be related to variant types of color vision.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"An irregular yellowish depression on the retina, about 3 degrees wide, lateral to and slightly below the optic disk; it is the site of absorption of short wavelengths of light, and it is thought that its variation in size, shape, and coloring may be related to variant types of color vision.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003015,,,,,,,BrendaTissueOBO,macula retinae|macula flava retinae,BTO:0003015,,,,,,,,,,,,,,,,,,,macula lutea,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100201,"[""Adenylate kinase 2, mitochondrial""]",,"An adenylate kinase 2, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54819] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391004,,,,,,,,"An adenylate kinase 2, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54819] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100201,,,,https://pharos.nih.gov/idg/targets/P54819,,,,,,,,,,,,,AK2,ADK2,,P54819,,,,,,,,"Adenylate kinase 2, mitochondrial",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200048,"[""CALCR gene""]",,"A calcitonin receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30988] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400028,,,,,,,,"A calcitonin receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30988] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200048,,,,,,,,,,,,,,,,799,CALCR,,,,,,,,,,,CALCR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004592,"[""bone matrix""]",,"The intercellular substance of bone tissue consisting of collagen fibers, ground substance, and inorganic bone salts.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The intercellular substance of bone tissue consisting of collagen fibers, ground substance, and inorganic bone salts.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004592,mgr,2010-04-12T07:56:37Z,,,,,BrendaTissueOBO,,BTO:0004592,,,,,,,,,,,,,,,,,,,bone matrix,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001275,"[""spermatocyte""]",,A cell giving rise to sperm cells; especially: a cell that is derived from a spermatogonium and ultimately gives rise to four haploid spermatids.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000535,,,,,,,,A cell giving rise to sperm cells; especially: a cell that is derived from a spermatogonium and ultimately gives rise to four haploid spermatids.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001275,,,,,,,BrendaTissueOBO,,BTO:0001275,,,,,,,,,,,,,,,,,,,spermatocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000356,"[""breast cancer cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000816,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000356,,,,,,,BrendaTissueOBO,breast carcinoma cell line,BTO:0000356,,,,,,,,,,,,,,,,,,,breast cancer cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000586,"[""colonic cancer cell""]",,A malignant tumour arising from the inner wall of the large intestine.,false,,,http://purl.obolibrary.org/obo/BTO_0001533|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A malignant tumour arising from the inner wall of the large intestine.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000586,,,,,,,BrendaTissueOBO,"colon cancer cell|carcinoma cell, colon|colonic carcinoma cell|colon carcinoma cell",BTO:0000586,,,,,,,,,,,,,,,,,,,colonic cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003776,"[""urinary bladder squamous cell carcinoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000792|http://purl.obolibrary.org/obo/BTO_0002024,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003776,,,,,,,BrendaTissueOBO,,BTO:0003776,,,,,,,,,,,,,,,,,,,urinary bladder squamous cell carcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_192,"[""sex cord-gonadal stromal tumor""]",,A reproductive organ cancer that is located_in the sex cord-derived tissues of the ovary and testis.,false,,,http://purl.obolibrary.org/obo/DOID_193,,,,,,,,A reproductive organ cancer that is located_in the sex cord-derived tissues of the ovary and testis.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:192,,,DOID:12293,NCI:C39948|NCI:C3794|SNOMEDCT_US_2016_03_01:253028001|UMLS_CUI:C1515289|UMLS_CUI:C0206724|MESH:D018312|SNOMEDCT_US_2016_03_01:71440001|SNOMEDCT_US_2016_03_01:189724009|SNOMEDCT_US_2016_03_01:115221000|SNOMEDCT_US_2016_03_01:134323003|SNOMEDCT_US_2016_03_01:189741006,"malignant testicular sex cord-stromal tumor|Specialized gonadal tumor (qualifier value)|Specialized gonadal neoplasm NOS (morphologic abnormality)|Sex cord stromal tumour|Specialized gonadal neoplasm (morphologic abnormality)|Sex Cord-Stromal tumor|Sex cord-stromal tumor, no ICD-O subtype (morphologic abnormality)|Sex Cord-Stromal neoplasm",,disease_ontology,,DOID:192,,,,,,,,,,,,,,,,,,,sex cord-gonadal stromal tumor,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_193,"[""reproductive organ cancer""]",,An organ system cancer that is manifested in the reproductive organs.,false,,,http://purl.obolibrary.org/obo/DOID_0050686|http://purl.obolibrary.org/obo/DOID_15,,,,,,,,An organ system cancer that is manifested in the reproductive organs.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:193,,,DOID:1900,UMLS_CUI:C0178830|NCI:C3674,Reproductive tumor|malignant reproductive system neoplasm,,disease_ontology,cancer of reproductive system,DOID:193,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,reproductive organ cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117521,"[""Nuclear receptor subfamily 4 group a member 2""]",,"A nuclear receptor subfamily 4 group A member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P43354] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117475,,,,,,,,"A nuclear receptor subfamily 4 group A member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P43354] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117521,,,,https://pharos.nih.gov/idg/targets/P43354,,,,,,,,,,,,,NR4A2,NURR1,,P43354,,,,,,,,Nuclear receptor subfamily 4 group a member 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200574,"[""ETNK2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200574,,,,,,,,,,,,,,,,,,,,,,,,,,,,ETNK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000026,"[""LEU103 in DAPK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000026,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU103 in DAPK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100357,"[""Serine/threonine-protein kinase nek3""]",,"serine/threonine-protein kinase nek3 (NEK3)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase Nek3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51956] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300197,,,,,,,,"serine/threonine-protein kinase nek3 (NEK3)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase Nek3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51956] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100357,,,,https://pharos.nih.gov/idg/targets/P51956,,,,,,,,,,,,,NEK3,,,P51956,,,,,,,,Serine/threonine-protein kinase nek3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001028,"[""peripheral nervous system""]",,"The peripheral nervous system (PNS) connects the central nervous system (CNS) to sensory organs (such as the eye and ear), other organs of the body, muscles, blood vessels and glands.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The peripheral nervous system (PNS) connects the central nervous system (CNS) to sensory organs (such as the eye and ear), other organs of the body, muscles, blood vessels and glands.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001028,,,,,,,BrendaTissueOBO,PNS,BTO:0001028,,,,,,,,,,,,,,,,,,,peripheral nervous system,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060091,"[""cardiovascular organ benign neoplasm""]",,"An organ system benign neoplasm disease located_in the blood, heart, blood vessels or the lymphatic system.",false,,,http://purl.obolibrary.org/obo/DOID_0060085,,,,,,,,"An organ system benign neoplasm disease located_in the blood, heart, blood vessels or the lymphatic system.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060091,lschriml,2011-07-14T01:45:15Z,,,,,disease_ontology,,DOID:0060091,,,,,,,,,,,,,,,,,,,cardiovascular organ benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060095,"[""uterine benign neoplasm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060086,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060095,lschriml,2011-07-15T01:42:11Z,DOID:0060113,,,,disease_ontology,,DOID:0060095,,,,,,,,,,,,,,,,,,,uterine benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060097,"[""thoracic benign neoplasm""]",,An organ system benign neoplam that is located_in the thoracic cavity.,false,,,http://purl.obolibrary.org/obo/DOID_0060085,,,,,,,,An organ system benign neoplam that is located_in the thoracic cavity.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060097,lschriml,2011-07-15T01:55:57Z,,,,,disease_ontology,,DOID:0060097,,,,,,,,,,,,,,,,,,,thoracic benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060090,"[""central nervous system organ benign neoplasm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060115,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060090,lschriml,2011-07-14T01:45:15Z,,,,,disease_ontology,,DOID:0060090,,,,,,,,,,,,,,,,,,,central nervous system organ benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060099,"[""musculoskeletal system benign neoplasm""]",,An organ system benign neoplasm that is located_in the muscular and skeletal organs.,false,,,http://purl.obolibrary.org/obo/DOID_0060085|http://purl.obolibrary.org/obo/DOID_17,,,,,,,,An organ system benign neoplasm that is located_in the muscular and skeletal organs.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060099,lschriml,2011-07-15T02:28:52Z,,,,,disease_ontology,,DOID:0060099,,,,,,,,,,,,,,,,,,,musculoskeletal system benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060094,"[""bone benign neoplasm""]",,A connective tissue benign neoplasm that is located_in bone.,false,,,http://purl.obolibrary.org/obo/DOID_0060123,,,,,,,,A connective tissue benign neoplasm that is located_in bone.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060094,lschriml,2011-07-15T01:34:59Z,,,,,disease_ontology,,DOID:0060094,,,,,,,,,,,,,,,,,,,bone benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300567,"[""Kv9.2/KCNS2 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300450,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300567,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv9.2/KCNS2 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000410,"[""THR84 in SIK3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000410,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR84 in SIK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200300,"[""SCN9A gene""]",,"This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq, Aug 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400474,,,,,,,,"This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq, Aug 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200300,,,,,,,,,,,,,,,,6335,SCN9A,NENA,,,,,,,,,,SCN9A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100323,"[""Olfactory receptor 10t2""]",,"An olfactory receptor 10T2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10T2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100323,,,,https://pharos.nih.gov/idg/targets/Q8NGX3,,,,,,,,,,,,,OR10T2,,,Q8NGX3,,,,,,,,Olfactory receptor 10t2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200221,"[""KCNK10 gene""]",,"The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400359,,,,,,,,"The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200221,,,,,,,,,,,,,,,,54207,KCNK10,TREK2,,,,,,,,,,KCNK10 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6088,"[""acute stress disorder""]",,"An anxiety disorder that has_symptom flashbacks, has_symptom bad dreams, has_symptom frightening thoughts, has_symptom avoidance or has_symptom hyperarousal of PTSD occurring within one month of a traumatic experience as Acute Stress Disorder or ASD.",false,,,http://purl.obolibrary.org/obo/DOID_2030,,,,,,,,"An anxiety disorder that has_symptom flashbacks, has_symptom bad dreams, has_symptom frightening thoughts, has_symptom avoidance or has_symptom hyperarousal of PTSD occurring within one month of a traumatic experience as Acute Stress Disorder or ASD.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6088,,,,ICD9CM:308.3|UMLS_CUI:C0029488|SNOMEDCT_US_2016_03_01:192043003|SNOMEDCT_US_2016_03_01:192040000,traumatic stress disorder,,disease_ontology,,DOID:6088,,,,,,,,,,,,,,,,,,,acute stress disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12733,"[""hypercementosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_214,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12733,,,,ICD9CM:521.5|MESH:D006936|ICD10CM:K03.4|SNOMEDCT_US_2016_03_01:78537008|UMLS_CUI:C0020441,Cementation hyperplasia,,disease_ontology,,DOID:12733,,,,,,,,,,,,,,,,,,,hypercementosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000006,"[""ABL1(F317I) kinase domain""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000006,,,,,,,,,,,,,,,,,,,,,,,,,,,,ABL1(F317I) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004523,"[""TM-3 cell""]",,Mouse Leydig cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0004522,,,,,,,,Mouse Leydig cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004523,mgr,2010-02-11T08:09:27Z,,,,,BrendaTissueOBO,TM3 cell,BTO:0004523,,,,,,,,,,,,,,,,,,,TM-3 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100474,"[""Serine/threonine kinase-like domain-containing protein stkld1""]",,"A protein kinase-like protein SgK071 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NE28] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300225,,,,,,,,"A protein kinase-like protein SgK071 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NE28] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100474,,,,https://pharos.nih.gov/idg/targets/Q8NE28,,,,,,,,,,,,,STKLD1,C9orf96|SGK071,,Q8NE28,,,,,,,,Serine/threonine kinase-like domain-containing protein stkld1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100255,"[""Glutamate receptor ionotropic, NMDA 3A""]",,"A glutamate receptor ionotropic, NMDA 3A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TCU5] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300453,,,,,,,,"A glutamate receptor ionotropic, NMDA 3A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TCU5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100255,,,,https://pharos.nih.gov/idg/targets/Q8TCU5,,,,,,,,,,,,,GRIN3A,KIAA1973,,Q8TCU5,,,,,,,,"Glutamate receptor ionotropic, NMDA 3A",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117494,"[""Oxysterols receptor lxr-alpha""]",,"An oxysterols receptor LXR-alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13133] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117465,,,,,,,,"An oxysterols receptor LXR-alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13133] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117494,,,,https://pharos.nih.gov/idg/targets/Q13133,,,,,,,,,,,,,NR1H3,,,Q13133,,,,,,,,Oxysterols receptor lxr-alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200259,"[""RPS6KC1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400179,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200259,,,,,,,,,,,,,,,,26750,RPS6KC1,RPK118,,,,,,,,,,RPS6KC1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000413,"[""SNRK kinase domain""]",,SNF-related serine/threonine-protein kinase; SNF1-related kinase; DKFZp779A1866; FLJ20224; HSNFRK; KIAA0096; SNRK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,SNF-related serine/threonine-protein kinase; SNF1-related kinase; DKFZp779A1866; FLJ20224; HSNFRK; KIAA0096; SNRK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000413,,,,,,,,,,,,,,,,,,,200414,,,,,,,,,SNRK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200314,"[""TMC6 gene""]",,"Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400329,,,,,,,,"Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200314,,,,,,,,,,,,,,,,11322,TMC6,EVER1|EVIN1,,,,,,,,,,TMC6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001531,"[""glial cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0000255|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001531,,,,,,,BrendaTissueOBO,,BTO:0001531,,,,,,,,,,,,,,,,,,,glial cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9275,"[""tyrosinemia""]",,An amino acid metabolic disorder that involves impaired break down of the amino acid tyrosine.,false,,,http://purl.obolibrary.org/obo/DOID_9252,,,,,,,,An amino acid metabolic disorder that involves impaired break down of the amino acid tyrosine.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9275,,,,SNOMEDCT_US_2016_03_01:190694001|NCI:C98640|MESH:D020176|ICD10CM:E70.21|UMLS_CUI:C0268483,,,disease_ontology,,DOID:9275,,,,,,,,,,,,,,,,,OMIM mapping submitted by NeuroDevNet. [LS].,,tyrosinemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100363,"[""Olfactory receptor 2ag2""]",,"An olfactory receptor 2AG2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NM03] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2AG2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NM03] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100363,,,,https://pharos.nih.gov/idg/targets/A6NM03,,,,,,,,,,,,,OR2AG2,OR2AG2P,,A6NM03,,,,,,,,Olfactory receptor 2ag2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100549,"[""Non-receptor tyrosine-protein kinase tyk2""]",,"non-receptor tyrosine-protein kinase tyk2 (TYK2(JH1domain-catalytic))  with  no mutation  in a nonphosphorylated state|A non-receptor tyrosine-protein kinase TYK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P29597] |non-receptor tyrosine-protein kinase tyk2 (TYK2(JH2domain-pseudokinase))  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300167,,,,,,,,"non-receptor tyrosine-protein kinase tyk2 (TYK2(JH1domain-catalytic))  with  no mutation  in a nonphosphorylated state|A non-receptor tyrosine-protein kinase TYK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P29597] |non-receptor tyrosine-protein kinase tyk2 (TYK2(JH2domain-pseudokinase))  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100549,,,,https://pharos.nih.gov/idg/targets/P29597,,,,,,,,,,,,,TYK2,,,P29597,,,,,,,,Non-receptor tyrosine-protein kinase tyk2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100746,"[""Prostaglandin E2 receptor EP4 subtype""]",,"A prostaglandin E2 receptor EP4 subtype that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35408] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A prostaglandin E2 receptor EP4 subtype that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35408] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100746,,,,https://pharos.nih.gov/idg/targets/P35408,,,,,,,,,,,,,PTGER4,PTGER2,,P35408,,,,,,,,Prostaglandin E2 receptor EP4 subtype,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_201,"[""connective tissue cancer""]",,A musculoskeletal system cancer that is located_in connective tissue.,false,,,http://purl.obolibrary.org/obo/DOID_0060100|http://purl.obolibrary.org/obo/DOID_65,,,,,,,,A musculoskeletal system cancer that is located_in connective tissue.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:201,,,,MESH:D009372|SNOMEDCT_US_2016_03_01:126598008|SNOMEDCT_US_2016_03_01:254821003|UMLS_CUI:C0027656,Tumour of connective tissue|neoplasm of connective tissues|connective tissue neoplasm,,disease_ontology,,DOID:201,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,connective tissue cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_203,"[""exostosis""]",,A hyperostosis that involves formation of new bone on the surface of preexisting bone.,false,,,http://purl.obolibrary.org/obo/DOID_205,,,,,,,,A hyperostosis that involves formation of new bone on the surface of preexisting bone.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:203,,,,ICD10CM:M27.8|SNOMEDCT_US_2016_03_01:267997004|UMLS_CUI:C1442903|MESH:D005096|SNOMEDCT_US_2016_03_01:416189003|NCI:C3029|SNOMEDCT_US_2016_03_01:156665008|ICD9CM:726.91|SNOMEDCT_US_2016_03_01:268091003|SNOMEDCT_US_2016_03_01:80400009|SNOMEDCT_US_2016_03_01:202894007,swimmer's exostosis|bony outgrowth|orbital exostosis|osteophyte|bone spur,,disease_ontology,,DOID:203,,,,,,,,,,,,,,,,,,,exostosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_205,"[""hyperostosis""]",,A bone remodeling disease that results in an abnormal growth of located_in bone.,false,,,http://purl.obolibrary.org/obo/DOID_0080005,,,,,,,,A bone remodeling disease that results in an abnormal growth of located_in bone.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:205,,,,SNOMEDCT_US_2016_03_01:13814009|SNOMEDCT_US_2016_03_01:203514008|MESH:D015576|ICD10CM:M89.3|ICD10CM:M89.30|NCI:C34712|UMLS_CUI:C0020492,hypertrophy of bone (morphologic abnormality)|hypertrophy of bone (disorder)|hypertrophy of bone|bone hypertrophy,,disease_ontology,,DOID:205,,,,,,,,,,,,,,,,,,,hyperostosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_200,"[""giant cell tumor""]",,,false,,,http://purl.obolibrary.org/obo/DOID_201,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:200,,,,MESH:D005870|SNOMEDCT_US_2016_03_01:134300001|SNOMEDCT_US_2016_03_01:115238001|UMLS_CUI:C0017525|SNOMEDCT_US_2016_03_01:189893004|SNOMEDCT_US_2016_03_01:443790001|NCI:C3055|SNOMEDCT_US_2016_03_01:189890001|NCI:C7069,Giant cell tumor (qualifier value)|Giant cell neoplasm|Giant cell tumor (morphologic abnormality)|Giant cell tumors (morphologic abnormality)|Giant cell tumor NOS (morphologic abnormality)|tumor of the Giant cell,,disease_ontology,Giant cell tumors,DOID:200,,,,,,,,,,,,,,,,,,,giant cell tumor,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_204,"[""enthesopathy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_65,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:204,,,,SNOMEDCT_US_2016_03_01:278525009|MESH:D012216|SNOMEDCT_US_2016_03_01:23680005|UMLS_CUI:C0242490|ICD9CM:726.90|ICD10CM:M77.9|ICD9CM:726.9|SNOMEDCT_US_2016_03_01:202890003,,,disease_ontology,,DOID:204,,,,,,,,,,,,,,,,,,,enthesopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1100,"[""ovarian disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_229,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1100,,,,UMLS_CUI:C0029928|NCI:C26841|MESH:D010049|SNOMEDCT_US_2016_03_01:5552004,,,disease_ontology,,DOID:1100,,,,,,,,,,,,,,,,,,,ovarian disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400502,"[""Beta-1/CHRNB1 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400502,,,,,,,,,,,,,,,,,,,,,,,,,,,,Beta-1/CHRNB1 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400301,"[""NuaK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400116,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400301,,,,,,,,,,,,,,,,,,,,,,,,,,,,NuaK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200531,"[""TNIK gene""]",,"Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400288,,,,,,,,"Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200531,,,,,,,,,,,,,,,,23043,TNIK,KIAA0551,,,,,,,,,,TNIK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5600,"[""precursor lymphoblastic lymphoma/leukemia""]",,A lymphoblastic leukemia that has_material_basis_in immature malignant lymphocytes (lymphoblasts) committed to the B-cell or T-cell lineage and located_in bone marrow and located_in peripheral blood.,false,,,http://purl.obolibrary.org/obo/DOID_1037,,,,,,,,A lymphoblastic leukemia that has_material_basis_in immature malignant lymphocytes (lymphoblasts) committed to the B-cell or T-cell lineage and located_in bone marrow and located_in peripheral blood.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5600,,,,MESH:D054198|NCI:C7055|UMLS_CUI:C1335469,,,disease_ontology,,DOID:5600,,,,,,,,,,,,,,,,,,,precursor lymphoblastic lymphoma/leukemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100096,"[""Free fatty acid receptor 3""]",,"A free fatty acid receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14843] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300040,,,,,,,,"A free fatty acid receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14843] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100096,,,,https://pharos.nih.gov/idg/targets/O14843,,,,,,,,,,,,,FFAR3,GPR41,,O14843,,,,,,,,Free fatty acid receptor 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200488,"[""OR1F2P gene""]",,"An olfactory receptor 1F2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R84] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1F2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R84] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200488,,,,,,,,,,,,,,,,26184,OR1F2P,OR1F2,,,,,,,,,,OR1F2P gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5679,"[""retinal disease""]",,An eye disease that is located_in the retina.,false,,,http://purl.obolibrary.org/obo/DOID_5614,,,,,,,,An eye disease that is located_in the retina.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5679,,,,SNOMEDCT_US_2016_03_01:399625000|SNOMEDCT_US_2016_03_01:193430004|NCI:C62601|MESH:D012164|UMLS_CUI:C0035309|SNOMEDCT_US_2016_03_01:29555009|SNOMEDCT_US_2016_03_01:35426003|ICD10CM:H35.9|NCI:C26875|ICD9CM:362.9|SNOMEDCT_US_2016_03_01:267715002,,,disease_ontology,,DOID:5679,,,,,,,,,,,,,,,,,,,retinal disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11247,"[""disseminated intravascular coagulation""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2452,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11247,,,,ICD10CM:D65|UMLS_CUI:C0012739|SNOMEDCT_US_2016_03_01:67406007|SNOMEDCT_US_2016_03_01:267563002|NCI:C2992|ICD9CM:286.6|MESH:D004211,DIC|Defibrination syndrome|Diffuse or disseminated intravascular coagulation,,disease_ontology,,DOID:11247,,,,,,,,,,,,,,,,,,,disseminated intravascular coagulation,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11249,"[""vitamin K deficiency hemorrhagic disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5113,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11249,,,,UMLS_CUI:C0042880|ICD10CM:E56.1|MESH:D014813|SNOMEDCT_US_2016_03_01:124892003|SNOMEDCT_US_2016_03_01:52675005|NCI:C99108|ICD9CM:269.0,deficiency of vitamin K (disorder)|vitamin K deficiency|deficiency of vitamin K|vitamin K deficiency (disorder),,disease_ontology,,DOID:11249,,,,,,,,,,,,,,,,,,,vitamin K deficiency hemorrhagic disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000252,"[""MAP3K14 kinase domain""]",,Mitogen-activated protein kinase kinase kinase 14; NF-kappa-beta-inducing kinase; NIK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase kinase kinase 14; NF-kappa-beta-inducing kinase; NIK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000252,,,,,,,,,,,,,,,,,,,201107,,,,,,,,,MAP3K14 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200245,"[""PRKCH gene""]",,"Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400278,,,,,,,,"Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200245,,,,,,,,,,,,,,,,5583,PRKCH,PKCL|PRKCL,,,,,,,,,,PRKCH gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100111,"[""Gamma-aminobutyric acid receptor subunit alpha-5""]",,"A gamma-aminobutyric acid receptor subunit alpha-5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P31644] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300510,,,,,,,,"A gamma-aminobutyric acid receptor subunit alpha-5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P31644] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100111,,,,https://pharos.nih.gov/idg/targets/P31644,,,,,,,,,,,,,GABRA5,,,P31644,,,,,,,,Gamma-aminobutyric acid receptor subunit alpha-5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100100,"[""Protein FAM26F""]",,"A protein FAM26F that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5R3K3] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300347,,,,,,,,"A protein FAM26F that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5R3K3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100100,,,,https://pharos.nih.gov/idg/targets/Q5R3K3,,,,,,,,,,,,441168,Protein FAM26F|FAM26F,C6orf187,,Q5R3K3,,,,,,,,Protein FAM26F,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001419,"[""urine""]",,"Waste material that is secreted by the kidney in vertebrates, is rich in end products of protein metabolism together with salts and pigments, and forms a clear amber and usually slightly acid fluid in mammals but is semisolid in birds and reptiles.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Waste material that is secreted by the kidney in vertebrates, is rich in end products of protein metabolism together with salts and pigments, and forms a clear amber and usually slightly acid fluid in mammals but is semisolid in birds and reptiles.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001419,,,,,,,BrendaTissueOBO,,BTO:0001419,,,,,,,,,,,,,,,,,,,urine,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005182,"[""TOV-112D cell""]",,This cell line was initiated in October of 1992 from a patient with early onset ovarian cancer. The patient was of French-Canadian descent with an unknown family history of ovarian cancer.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000811,,,,,,,,This cell line was initiated in October of 1992 from a patient with early onset ovarian cancer. The patient was of French-Canadian descent with an unknown family history of ovarian cancer.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005182,XPMUser,2011-08-30T01:15:33Z,,,,,BrendaTissueOBO,,BTO:0005182,,,,,,,,,,,,,,,,,,,TOV-112D cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1824,"[""status epilepticus""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1826,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1824,,,,SNOMEDCT_US_2016_03_01:192998006|SNOMEDCT_US_2016_03_01:193019007|NCI:C85079|MESH:D013226|UMLS_CUI:C0038220|SNOMEDCT_US_2016_03_01:155039002|SNOMEDCT_US_2016_03_01:230456007|SNOMEDCT_US_2016_03_01:194499008|SNOMEDCT_US_2016_03_01:13973009,(Grand mal status) or (status epilepticus),,disease_ontology,,DOID:1824,,,,,,,,,,,,,,,,,,,status epilepticus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400581,"[""TRPC6 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400482,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400581,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPC6 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200004,"[""PRKAA1 gene""]",,"The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400245,,,,,,,,"The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200004,,,,,,,,,,,,,,,,5562,PRKAA1,AMPK1,,,,,,,,,,PRKAA1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3620,"[""central nervous system cancer""]",,A nervous system cancer that is located_in the central nervous system.,false,,,http://purl.obolibrary.org/obo/DOID_3093|http://purl.obolibrary.org/obo/DOID_331,,,,,,,,A nervous system cancer that is located_in the central nervous system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3620,,,DOID:0060093|DOID:1318,ICD10CM:C72.9|NCI:C4627|EFO:0000326|NCI:C9293|SNOMEDCT_US_2016_03_01:93744007|UMLS_CUI:C0348374|SNOMEDCT_US_2016_03_01:190135002|UMLS_CUI:C0085136|SNOMEDCT_US_2016_03_01:126951006|SNOMEDCT_US_2016_03_01:372062007|MESH:D016543,"CNS neoplasm|malignant neoplasm of central nervous system, NOS|malignant tumor of CNS|central nervous system tumors|neoplasm of central nervous system (disorder)|central nervous system tumor",,disease_ontology,,DOID:3620,,,,,,,,,,,,,,,,,,,central nervous system cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200275,"[""NMUR2 gene""]",,"A neuromedin-U receptor 2 that is encoded in the genome of human. [PRO:CNx, Reactome:REACT_27011] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400067,,,,,,,,"A neuromedin-U receptor 2 that is encoded in the genome of human. [PRO:CNx, Reactome:REACT_27011] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200275,,,,,,,,,,,,,,,,56923,NMUR2,NMU2R|TGR1,,,,,,,,,,NMUR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000232,"[""MET96 in RIPK4""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000232,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET96 in RIPK4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000247,"[""M3K6 kinase domain""]",,Mitogen-activated protein kinase kinase kinase 6; ASK2; MAP3K6; MAPKKK6; MEKK6; MEKK6/MAP3K6; MGC125653; MGC20114,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase kinase kinase 6; ASK2; MAP3K6; MAPKKK6; MEKK6; MEKK6/MAP3K6; MGC125653; MGC20114,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000247,,,,,,,,,,,,,,,,,,,200043,,,,,,,,,M3K6 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005426,"[""NB-69 cell""]",,"Human neuroblastoma brain (Stage III) cell line, isolated from a 16 month old male.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000932,,,,,,,,"Human neuroblastoma brain (Stage III) cell line, isolated from a 16 month old male.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005426,XPMUser,2013-03-18T04:58:01Z,,,,,BrendaTissueOBO,NB69 cell,BTO:0005426,,,,,,,,,,,,,,,,,,,NB-69 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200183,"[""KCNA4 gene""]",,"Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential.[provided by RefSeq, Mar 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400535,,,,,,,,"Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential.[provided by RefSeq, Mar 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200183,,,,,,,,,,,,,,,,3739,KCNA4,KCNA4L,,,,,,,,,,KCNA4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00000012,"[""carboxylic acid GPCR ligand""]",,A GPCR ligand that is classified as carboxylic acid in CHEBI.,false,,,http://www.drugtargetontology.org/dto/DTO_00000001|http://purl.obolibrary.org/obo/CHEBI_33575,,,,,,,,A GPCR ligand that is classified as carboxylic acid in CHEBI.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00000012,,,,,,,,,,,,,,,,,,,,,,,,,,,Asiyah Yu Lin,carboxylic acid GPCR ligand,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100225,"[""Cgmp-dependent protein kinase 2""]",,"cGMP-dependent protein kinase 2 (KGP2)  with  no mutation  in a nonphosphorylated state|A cGMP-dependent protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13237] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300173,,,,,,,,"cGMP-dependent protein kinase 2 (KGP2)  with  no mutation  in a nonphosphorylated state|A cGMP-dependent protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13237] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100225,,,,https://pharos.nih.gov/idg/targets/Q13237,,,,,,,,,,,,,PRKG2,PRKGR2,,Q13237,,,,,,,,Cgmp-dependent protein kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00000018,"[""BRENDA tissues and cell lines""]",,An umbrella term created for tissues and cell lines imported from BRENDA ontology.,false,,,http://www.w3.org/2002/07/owl#Thing,,,,,,,,An umbrella term created for tissues and cell lines imported from BRENDA ontology.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BRENDA tissues and cell lines,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050592,"[""asphyxiating thoracic dystrophy""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050737,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050592,,,,OMIM:PS208500|ICD10CM:Q77.2|ORDO:474,short-rib thoracic dysplasia with or without polydactyly|Jeune syndrome|thoracic pelvic phalangeal dystrophy,,disease_ontology,,DOID:0050592,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,asphyxiating thoracic dystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050598,"[""extrapulmonary tuberculosis""]",,A tuberculosis that occurs at body sites other than the lung.,false,,,http://purl.obolibrary.org/obo/DOID_399,,,,,,,,A tuberculosis that occurs at body sites other than the lung.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050598,,,,,,,disease_ontology,,DOID:0050598,,,,,,,,,,,,,,,,,,,extrapulmonary tuberculosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050597,"[""intestinal schistosomiasis""]",,"A schistosomiasis that involves parasitic infection of the intestine caused by Schistosoma mansoni, Schistosoma intercalatum or Schistosomiasis japonicum. The symptoms include fever, cough, abdominal pain, diarrhea, hepatosplenomegaly, colonic polyposis with bloody diarrhea and eosinophilia.",false,,,http://purl.obolibrary.org/obo/DOID_1395,,,,,,,,"A schistosomiasis that involves parasitic infection of the intestine caused by Schistosoma mansoni, Schistosoma intercalatum or Schistosomiasis japonicum. The symptoms include fever, cough, abdominal pain, diarrhea, hepatosplenomegaly, colonic polyposis with bloody diarrhea and eosinophilia.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050597,,,DOID:13692|DOID:13721|DOID:3468,SNOMEDCT_US_2016_03_01:52179003|ICD9CM:120.2|MESH:D012554|ORDO:1247|SNOMEDCT_US_2016_03_01:750009|SNOMEDCT_US_2016_03_01:268058007|NCI:C35002|OMIM:181460|MESH:D012555|ICD10CM:B65.1|ICD10CM:B65.2|UMLS_CUI:C0276932|SNOMEDCT_US_2016_03_01:187114003|ICD9CM:120.1|SNOMEDCT_US_2016_03_01:6421008|UMLS_CUI:C0036329|UMLS_CUI:C0036330|NCI:C35364|NCI:C35001,schistosomiasis japonica|Schistosoma japonicum infection|Katayama fever|Schistosoma mansoni infectious disease,,disease_ontology,,DOID:0050597,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,intestinal schistosomiasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050599,"[""abdominal tuberculosis""]",,"An extrapulmonary tuberculosis that is located_in gastrointestinal tract, located_in peritoneum, located_in omentum, located_in mesentery, located_in liver, located_in spleen or located_in pancreas.",false,,,http://purl.obolibrary.org/obo/DOID_0050598,,,,,,,,"An extrapulmonary tuberculosis that is located_in gastrointestinal tract, located_in peritoneum, located_in omentum, located_in mesentery, located_in liver, located_in spleen or located_in pancreas.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050599,,,,,,,disease_ontology,,DOID:0050599,,,,,,,,,,,,,,,,,,,abdominal tuberculosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050591,"[""tooth agenesis""]",,A tooth disease characterized by failure to develop on or more missing teeth.,false,,,http://purl.obolibrary.org/obo/DOID_1091,,,,,,,,A tooth disease characterized by failure to develop on or more missing teeth.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050591,,,,ICD9CM:520.0|SNOMEDCT_US_2016_03_01:234951001|SNOMEDCT_US_2016_03_01:26624006|OMIM:313500|MESH:D000848|SNOMEDCT_US_2016_03_01:196269004|OMIM:602639|ORDO:99798|OMIM:604625|OMIM:150400|ORDO:2227|SNOMEDCT_US_2016_03_01:196265005|SNOMEDCT_US_2016_03_01:16958000|ICD10CM:K00.0|OMIM:106600|OMIM:610926|SNOMEDCT_US_2016_03_01:196266006|UMLS_CUI:C0399352,hypodontia|oligodontia|familial tooth agenesis|selective tooth agenesis,,disease_ontology,,DOID:0050591,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,tooth agenesis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400541,"[""Kv3.1/KCNC1 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400443,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400541,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv3.1/KCNC1 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000153,"[""CCL15""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000153,,,,,,,,,,,,,,,,,,,,,,,,,,,,CCL15,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000014,"[""ABL1(H396P)-phosphorylated kinase domain""]",,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",false,,,http://www.drugtargetontology.org/dto/DTO_61000012,,,,,,,,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000014,,,,,,,,,,,,,,,,,,,200013,,,,,,,,,ABL1(H396P)-phosphorylated kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300020,"[""Acetylcholine receptor (muscarinic)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300020,,,,,,,,,,,,,,,,,,,,,,,,,,,,Acetylcholine receptor (muscarinic),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000424,"[""SYK kinase domain""]",,Tyrosine-protein kinase SYK; spleen tyrosine kinase; p72-Syk; DKFZp313N1010; FLJ25043; FLJ37489; SYK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Tyrosine-protein kinase SYK; spleen tyrosine kinase; p72-Syk; DKFZp313N1010; FLJ25043; FLJ37489; SYK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000424,,,,,,,,,,,,,,,,,,,200425,,,,,,,,,SYK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100483,"[""Olfactory receptor 1D5""]",,"An olfactory receptor 1D5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58170] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1D5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58170] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100483,,,,https://pharos.nih.gov/idg/targets/P58170,,,,,,,,,,,,,OR1D5,,,P58170,,,,,,,,Olfactory receptor 1D5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200339,"[""OR13A1 gene""]",,"An olfactory receptor 13A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 13A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200339,,,,,,,,,,,,,,,,79290,OR13A1,,,,,,,,,,,OR13A1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100005,"[""5'-AMP-activated protein kinase catalytic subunit alpha-2""]",,"A 5'-AMP-activated protein kinase catalytic subunit alpha-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54646] |5-amp-activated protein kinase catalytic subunit alpha-2 (AMPK-alpha2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300245,,,,,,,,"A 5'-AMP-activated protein kinase catalytic subunit alpha-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54646] |5-amp-activated protein kinase catalytic subunit alpha-2 (AMPK-alpha2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100005,,,,https://pharos.nih.gov/idg/targets/P54646,,,,,,,,,,,,,PRKAA2,AMPK|AMPK2,,P54646,,,,,,,,5'-AMP-activated protein kinase catalytic subunit alpha-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200595,"[""OR4K14 gene""]",,"An olfactory receptor 4K14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4K14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200595,,,,,,,,,,,,,,,,122740,OR4K14,,,,,,,,,,,OR4K14 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300143,"[""CASK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300143,,,,,,,,,,,,,,,,,,,,,,,,,,,,CASK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200042,"[""BDKRB1 gene""]",,"A B1 bradykinin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46663] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400025,,,,,,,,"A B1 bradykinin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46663] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200042,,,,,,,,,,,,,,,,623,BDKRB1,BRADYB1,,,,,,,,,,BDKRB1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200080,"[""CXCR6 gene""]",,"A C-X-C chemokine receptor type 6 that is encoded in the genome of human. [PRO:CNx, Reactome:REACT_14906] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400097,,,,,,,,"A C-X-C chemokine receptor type 6 that is encoded in the genome of human. [PRO:CNx, Reactome:REACT_14906] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200080,,,,,,,,,,,,,,,,10663,CXCR6,BONZO|STRL33|TYMSTR,,,,,,,,,,CXCR6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100222,"[""Potassium channel subfamily K member 12""]",,"A potassium channel subfamily K member 12 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HB15] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300359,,,,,,,,"A potassium channel subfamily K member 12 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HB15] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100222,,,,https://pharos.nih.gov/idg/targets/Q9HB15,,,,,,,,,,,,,KCNK12,,,Q9HB15,,,,,,,,Potassium channel subfamily K member 12,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100196,"[""Potassium voltage-gated channel subfamily E member 1""]",,"A potassium voltage-gated channel subfamily E member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P15382] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300445,,,,,,,,"A potassium voltage-gated channel subfamily E member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P15382] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100196,,,,https://pharos.nih.gov/idg/targets/P15382,,,,,,,,,,,,,KCNE1,,,P15382,,,,,,,,Potassium voltage-gated channel subfamily E member 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02402002,"[""5-HT2 receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400017,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02402002,,,,,,,,,,,,,,,,,,,,,,,,,,,,5-HT2 receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2234,"[""focal epilepsy""]",,"An epilepsy syndrome that is characterised by seizures that are preceded by an isolated disturbance of a cerebral function and arise from an epileptic focus, a small portion of the brain that serves as the irritant driving the epileptic response.",false,,,http://purl.obolibrary.org/obo/DOID_1826,,,,,,,,"An epilepsy syndrome that is characterised by seizures that are preceded by an isolated disturbance of a cerebral function and arise from an epileptic focus, a small portion of the brain that serves as the irritant driving the epileptic response.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2234,,,,UMLS_CUI:C0014547|SNOMEDCT_US_2016_03_01:29753000|SNOMEDCT_US_2016_03_01:155044009|SNOMEDCT_US_2016_03_01:193007004|MESH:D004828|SNOMEDCT_US_2016_03_01:155041001|SNOMEDCT_US_2016_03_01:230381009|NCI:C122812|SNOMEDCT_US_2016_03_01:67139004,partial epilepsy|localisation-related epilepsy,,disease_ontology,,DOID:2234,,,,,,,,,,,,,,,,,,,focal epilepsy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200172,"[""GPRC5B gene""]",,"A G-protein coupled receptor family C group 5 member B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZH0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400004,,,,,,,,"A G-protein coupled receptor family C group 5 member B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZH0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200172,,,,,,,,,,,,,,,,51704,GPRC5B,RAIG2,,,,,,,,,,GPRC5B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100464,"[""Serine/threonine-protein kinase sbk1""]",,"serine/threonine-protein kinase sbk1 (SBK1)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase SBK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q52WX2] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300222,,,,,,,,"serine/threonine-protein kinase sbk1 (SBK1)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase SBK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q52WX2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100464,,,,https://pharos.nih.gov/idg/targets/Q52WX2,,,,,,,,,,,,,SBK1,,,Q52WX2,,,,,,,,Serine/threonine-protein kinase sbk1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300253,"[""BRSK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300116,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300253,,,,,,,,,,,,,,,,,,,,,,,,,,,,BRSK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1731,"[""histoplasmosis""]",,"A primary systemic mycosis that results_in systemic fungal infection, has_material_basis_in Histoplasma capsulatum var capsulatum or has_material_basis_in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and has_symptom nonproductive cough, has_symptom headache, has_symptom loss of appetite and has_symptom muscle pains.",false,,,http://purl.obolibrary.org/obo/DOID_0050292,,,,,,,,"A primary systemic mycosis that results_in systemic fungal infection, has_material_basis_in Histoplasma capsulatum var capsulatum or has_material_basis_in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and has_symptom nonproductive cough, has_symptom headache, has_symptom loss of appetite and has_symptom muscle pains.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1731,,,DOID:351,MESH:C538362|SNOMEDCT_US_2016_03_01:154408001|MESH:D006660|SNOMEDCT_US_2016_03_01:12962009|ICD9CM:115|UMLS_CUI:C0035288|ICD10CM:B39.9|NCI:C77201|SNOMEDCT_US_2016_03_01:187063001|ICD9CM:115.9|SNOMEDCT_US_2016_03_01:187055002|SNOMEDCT_US_2016_03_01:266218008|SNOMEDCT_US_2016_03_01:187482000|SNOMEDCT_US_2016_03_01:187056001|ICD10CM:B39|NCI:C34977|UMLS_CUI:C0019655,,,disease_ontology,,DOID:1731,,,,,,,,,,,,,,,,,,,histoplasmosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_7148,"[""rheumatoid arthritis""]",,An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint.,false,,,http://purl.obolibrary.org/obo/DOID_848,,,,,,,,An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:7148,,,,NCI:C2884|ICD9CM:714.0|KEGG:05323|ICD10CM:M06.9|SNOMEDCT_US_2016_03_01:287010008|EFO:0000685|OMIM:180300|MESH:D001172|SNOMEDCT_US_2016_03_01:69896004|SNOMEDCT_US_2016_03_01:156471009|UMLS_CUI:C0003873|NCI:C27206|SNOMEDCT_US_2016_03_01:156481008,"atrophic Arthritis|Arthritis or polyarthritis, rheumatic",,disease_ontology,,DOID:7148,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,rheumatoid arthritis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400110,"[""RGC group gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400102,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400110,,,,,,,,,,,,,,,,,,,,,,,,,,,,RGC group gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100253,"[""Ribosomal protein s6 kinase alpha-3""]",,"ribosomal protein s6 kinase alpha-3 (RSK2(Kin.Dom.2-C-terminal))  with  no mutation  in a nonphosphorylated state|A ribosomal protein S6 kinase alpha-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51812] |ribosomal protein s6 kinase alpha-3 (RSK2(Kin.Dom.1-N-terminal))  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300280,,,,,,,,"ribosomal protein s6 kinase alpha-3 (RSK2(Kin.Dom.2-C-terminal))  with  no mutation  in a nonphosphorylated state|A ribosomal protein S6 kinase alpha-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51812] |ribosomal protein s6 kinase alpha-3 (RSK2(Kin.Dom.1-N-terminal))  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100253,,,,https://pharos.nih.gov/idg/targets/P51812,,,,,,,,,,,,,RPS6KA3,ISPK1|MAPKAPK1B|RSK2,,P51812,,,,,,,,Ribosomal protein s6 kinase alpha-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004256,"[""long bone""]",,In limbs of vertebrate animals. A long cylindrical bone that contains marrow.,false,,,http://purl.obolibrary.org/obo/UBERON_0001474|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000140,,,,,,,,In limbs of vertebrate animals. A long cylindrical bone that contains marrow.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004256,Marion,2010-01-29T03:14:18Z,,,,,BrendaTissueOBO,os longum,BTO:0004256,,,,,,,,,,,,,,,,,,,long bone,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100148,"[""Voltage-gated hydrogen channel 1""]",,"A voltage-gated hydrogen channel 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96D96] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300352,,,,,,,,"A voltage-gated hydrogen channel 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96D96] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100148,,,,https://pharos.nih.gov/idg/targets/Q96D96,,,,,,,,,,,,,HVCN1,VSOP,,Q96D96,,,,,,,,Voltage-gated hydrogen channel 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200158,"[""GPR157 gene""]",,"A G-protein coupled receptor 157 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q5UAW9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400003,,,,,,,,"A G-protein coupled receptor 157 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q5UAW9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200158,,,,,,,,,,,,,,,,80045,GPR157,,,,,,,,,,,GPR157 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000423,"[""VAL561 in FGFR1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000423,,,,,,,,,,,,,,,,,,,,,,,,,,,,VAL561 in FGFR1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400172,"[""CAMK2 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400172,,,,,,,,,,,,,,,,,,,,,,,,,,,,CAMK2 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00000011,"[""amino acid GPCR ligand""]",,A GPCR ligand that is classified as amino acid in CHEBI.,false,,,http://purl.obolibrary.org/obo/CHEBI_33709|http://www.drugtargetontology.org/dto/DTO_00000001,,,,,,,,A GPCR ligand that is classified as amino acid in CHEBI.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00000011,,,,,,,,,,,,,,,,,,,,,,,,,,,Asiyah Yu Lin,amino acid GPCR ligand,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003834,"[""conceptus""]",,"A fertilized egg, embryo, or fetus.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000174,,,,,,,,"A fertilized egg, embryo, or fetus.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003834,,,,,,,BrendaTissueOBO,,BTO:0003834,,,,,,,,,,,,,,,,,,,conceptus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060262,"[""gallbladder disease""]",,A gastrointestinal system disease that is located_in the gallbladder.,false,,,http://purl.obolibrary.org/obo/DOID_77,,,,,,,,A gastrointestinal system disease that is located_in the gallbladder.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060262,emitraka,2015-02-02T15:48:08Z,DOID:0000000,SNOMEDCT_US_2016_03_01:155807008|ICD10CM:K82.9|MESH:D005705|SNOMEDCT_US_2016_03_01:266535008|UMLS_CUI:C0016977|SNOMEDCT_US_2016_03_01:266543003|SNOMEDCT_US_2016_03_01:155829007|OMIM:609919|SNOMEDCT_US_2016_03_01:39621005|SNOMEDCT_US_2016_03_01:155826000|NCI:C34631|OMIM:611465|ICD9CM:575.9|OMIM:609918|SNOMEDCT_US_2016_03_01:266542008,,,disease_ontology,,DOID:0060262,http://purl.obolibrary.org/obo/doid#NCIthesaurus,,,,,,,,,,,,,,,,Xref MGI.,,gallbladder disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060260,"[""ptosis""]",,An eye disease characterized by the drooping or falling of the upper or lower eyelid.,false,,,http://purl.obolibrary.org/obo/DOID_5614,,,,,,,,An eye disease characterized by the drooping or falling of the upper or lower eyelid.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060260,emitraka,2015-01-30T16:46:53Z,,ICD10CM:H02.40|SNOMEDCT_US_2016_03_01:193945000|ICD9CM:374.30|SNOMEDCT_US_2016_03_01:204197004|UMLS_CUI:C0005745|MESH:D001763|ICD9CM:374.3|SNOMEDCT_US_2016_03_01:193943007|NCI:C27298|HP:0000508|SNOMEDCT_US_2016_03_01:11934000|ICD10CM:H02.4|SNOMEDCT_US_2016_03_01:193942002|SNOMEDCT_US_2016_03_01:155179008|ICD10CM:H02.409,blepharoptosis|drooping eyelid,,disease_ontology,,DOID:0060260,,,,,,,,,,,,,,,,,NT MGI add.,,ptosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060264,"[""pontocerebellar hypoplasia""]",,NT MGI add.,false,,,http://purl.obolibrary.org/obo/DOID_1289,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060264,emitraka,2015-02-04T14:23:25Z,,MESH:C580383|SNOMEDCT_US_2016_03_01:45163000|UMLS_CUI:C0266468,PCH,,disease_ontology,,DOID:0060264,,,,,,,,,,,,,,,,,NT MGI add.,,pontocerebellar hypoplasia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060263,"[""porencephaly""]",,NT MGI.,false,,,http://purl.obolibrary.org/obo/DOID_936,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060263,emitraka,2015-02-04T14:12:00Z,,UMLS_CUI:C3698507|MESH:D065708|SNOMEDCT_US_2016_03_01:38353004|HP:0002132|ICD10CM:Q04.6|SNOMEDCT_US_2016_03_01:204071008|ORDO:2940|SNOMEDCT_US_2016_03_01:698837003|OMIM:175780|UMLS_CUI:C0302892|OMIM:614483|UMLS_CUI:C1867983,,,disease_ontology,,DOID:0060263,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,NT MGI.,,porencephaly,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100823,"[""Vomeronasal type-1 receptor 4""]",,"A vomeronasal type-1 receptor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z5H5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300016,,,,,,,,"A vomeronasal type-1 receptor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z5H5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100823,,,,https://pharos.nih.gov/idg/targets/Q7Z5H5,,,,,,,,,,,,,VN1R4,V1RL4,,Q7Z5H5,,,,,,,,Vomeronasal type-1 receptor 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300575,"[""MCOLN2 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300452,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300575,,,,,,,,,,,,,,,,,,,,,,,,,,,,MCOLN2 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300427,"[""KCNJ16 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300427,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ16 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000224,"[""KPCD kinase domain""]",,"Protein kinase C, delta; May1; MGC49908; nPKC-delta; PKCD; PRKCD",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Protein kinase C, delta; May1; MGC49908; nPKC-delta; PKCD; PRKCD",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000224,,,,,,,,,,,,,,,,,,,200354,,,,,,,,,KPCD kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3733,"[""theileriasis""]",,"A parasitic protozoa infectious disease that involves infection of humans and cattle caused by a genus of parasitic protozoa Theileria, which is transmitted by ixodid ticks.",false,,,http://purl.obolibrary.org/obo/DOID_2789,,,,,,,,"A parasitic protozoa infectious disease that involves infection of humans and cattle caused by a genus of parasitic protozoa Theileria, which is transmitted by ixodid ticks.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3733,,,,MESH:D013801|SNOMEDCT_US_2016_03_01:68771000|UMLS_CUI:C0039753,Infection by Theileria (disorder)|theileriosis,,disease_ontology,,DOID:3733,http://purl.obolibrary.org/obo/doid#tick-borne_infectious_disease,,,,,,,,,,,,,,,,,,theileriasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200108,"[""GABRA2 gene""]",,"GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_01400507,,,,,,,,"GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200108,,,,,,,,,,,,,,,,2555,GABRA2,,,,,,,,,,,GABRA2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000246,"[""PHE178 in CDK15""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000246,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE178 in CDK15,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004270,"[""adult liver stem cell""]",,Hepatic progenitor cells can be isolated from fetal liver and extrahepatic tissues.,false,,,http://purl.obolibrary.org/obo/BTO_0002666|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Hepatic progenitor cells can be isolated from fetal liver and extrahepatic tissues.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004270,,,,,,,BrendaTissueOBO,hepatic progenitor cell|hepatic oval cell|HPC cell|adulte Leberstammzelle,BTO:0004270,,,,,,,,,,,,,,,,,,,adult liver stem cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000791,"[""BW-5147 cell""]",,Mouse AKR/J thymic lymphoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001377,,,,,,,,Mouse AKR/J thymic lymphoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000791,,,,,,,BrendaTissueOBO,BW5147 cell,BTO:0000791,,,,,,,,,,,,,,,,,,,BW-5147 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000028,"[""Annexin I-(2-26)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000028,,,,,,,,,,,,,,,,,,,,,,,,,,,,Annexin I-(2-26),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200582,"[""GK3P gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200582,,,,,,,,,,,,,,,,,,,,,,,,,,,,GK3P gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200473,"[""SGK3 gene""]",,"This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400224,,,,,,,,"This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200473,,,,,,,,,,,,,,,,100533105|23678,SGK3,CISK|SGKL,,,,,,,,,,SGK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200634,"[""OR5L1 gene""]",,"An olfactory receptor 5L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200634,,,,,,,,,,,,,,,,219437,OR5L1,,,,,,,,,,,OR5L1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000330,"[""PCTK3 kinase domain""]",,Cyclin-dependent kinase 18; CDK18; PCTAIRE; PCTAIRE3; PCTK3,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Cyclin-dependent kinase 18; CDK18; PCTAIRE; PCTAIRE3; PCTK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000330,,,,,,,,,,,,,,,,,,,200311,,,,,,,,,PCTK3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004687,"[""orbit""]",,The bony socket of the eye.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The bony socket of the eye.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004687,mgr,2010-05-14T09:56:53Z,,,,,BrendaTissueOBO,,BTO:0004687,,,,,,,,,,,,,,,,,,,orbit,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4160,"[""differentiating neuroblastoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_769,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4160,,,,UMLS_CUI:C1511934|NCI:C42048,,,disease_ontology,,DOID:4160,,,,,,,,,,,,,,,,,,,differentiating neuroblastoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100221,"[""Potassium channel subfamily K member 10""]",,"A potassium channel subfamily K member 10 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P57789] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300359,,,,,,,,"A potassium channel subfamily K member 10 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P57789] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100221,,,,https://pharos.nih.gov/idg/targets/P57789,,,,,,,,,,,,,KCNK10,TREK2,,P57789,,,,,,,,Potassium channel subfamily K member 10,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200061,"[""CACNG7 gene""]",,"The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. [provided by RefSeq, Dec 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400336,,,,,,,,"The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. [provided by RefSeq, Dec 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200061,,,,,,,,,,,,,,,,59284,CACNG7,,,,,,,,,,,CACNG7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3262,"[""phagocyte bactericidal dysfunction""]",,A primary immunodeficiency disease where phagocytes have a diminished ability to fight bacterial infection.,false,,,http://purl.obolibrary.org/obo/DOID_612,,,,,,,,A primary immunodeficiency disease where phagocytes have a diminished ability to fight bacterial infection.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3262,,,,MESH:D010585|UMLS_CUI:C0031306,phagocytic dysfunction,,disease_ontology,,DOID:3262,,,,,,,,,,,,,,,,,,,phagocyte bactericidal dysfunction,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100315,"[""Olfactory receptor 10J5""]",,"An olfactory receptor 10J5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHC4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10J5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHC4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100315,,,,https://pharos.nih.gov/idg/targets/Q8NHC4,,,,,,,,,,,,,OR10J5,,,Q8NHC4,,,,,,,,Olfactory receptor 10J5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000121,"[""EGFR(E746-A750del) kinase domain""]",,"Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000121,,,,,,,,,,,,,,,,,,,200123,,,,,,,,,EGFR(E746-A750del) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100621,"[""Ribose-phosphate pyrophosphokinase 2""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100621,,,,,,,,,,,,,,,,,PRPS2,,,P11908,,,,,,,,Ribose-phosphate pyrophosphokinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5403,"[""microcystic adenoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_657,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5403,,,,NCI:C3685|MESH:D000236|UMLS_CUI:C0205648|SNOMEDCT_US_2016_03_01:79494009|SNOMEDCT_US_2016_03_01:189580001,Microcystic adenoma (morphologic abnormality)|Microcystic adenoma,,disease_ontology,,DOID:5403,,,,,,,,,,,,,,,,,,,microcystic adenoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000427,"[""pituitary gland cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000427,,,,,,,BrendaTissueOBO,,BTO:0000427,,,,,,,,,,,,,,,,,,,pituitary gland cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000407,"[""SGK3 kinase domain""]",,Serine/threonine-protein kinase Sgk3; Serum/glucocorticoid-regulated kinase 3; CISK; DKFZp781N0293; SGKL,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase Sgk3; Serum/glucocorticoid-regulated kinase 3; CISK; DKFZp781N0293; SGKL,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000407,,,,,,,,,,,,,,,,,,,200409,,,,,,,,,SGK3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060162,"[""dentatorubral-pallidoluysian atrophy""]",,An autosomal dominant cerebellar ataxia that has_material_basis_in expansion of  CAG triplet repeats (glutamine) encoding a polyglutamine tract in the atrophin-1 protein.,false,,,http://purl.obolibrary.org/obo/DOID_1441,,,,,,,,An autosomal dominant cerebellar ataxia that has_material_basis_in expansion of  CAG triplet repeats (glutamine) encoding a polyglutamine tract in the atrophin-1 protein.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060162,lschriml,2011-08-29T01:41:48Z,,SNOMEDCT_US_2016_03_01:89480000|OMIM:125370|SNOMEDCT_US_2016_03_01:68116008|MESH:D020191|UMLS_CUI:C0751779|NCI:C122653|NCI:C7636|UMLS_CUI:C0751778|UMLS_CUI:C0751782|SNOMEDCT_US_2016_03_01:702422004|SNOMEDCT_US_2016_03_01:192844008|UMLS_CUI:C0751781|UMLS_CUI:C0751777|SNOMEDCT_US_2016_03_01:267581004|UMLS_CUI:C0751776|UMLS_CUI:C0751780,DRPLA|Naito-Oyanagi disease|Haw River Syndrome,,disease_ontology,,DOID:0060162,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,dentatorubral-pallidoluysian atrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060165,"[""Kleine-Levin syndrome""]",,A recurrent hypersomnia that is characterized by recurring periods of excessive amounts of sleep and altered behavior.,false,,,http://purl.obolibrary.org/obo/DOID_8619,,,,,,,,A recurrent hypersomnia that is characterized by recurring periods of excessive amounts of sleep and altered behavior.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060165,lschriml,2011-09-07T02:46:02Z,,,,,disease_ontology,,DOID:0060165,,,,,,,,,,,,,,,,,,,Kleine-Levin syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060169,"[""benign familial infantile epilepsy""]",,"An infancy electroclinical syndrome that is characterized by convulsions, with onset at age 3 to 12 months.",false,,,http://purl.obolibrary.org/obo/DOID_0050703,,,,,,,,"An infancy electroclinical syndrome that is characterized by convulsions, with onset at age 3 to 12 months.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060169,lschriml,2011-10-28T02:55:02Z,,OMIM:605751|OMIM:601764|OMIM:612627|ORDO:306|OMIM:607745,benign familial infantile convulsion|benign familial infantile seizures|BFIE |BFIC,,disease_ontology,,DOID:0060169,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,benign familial infantile epilepsy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060163,"[""body dysmorphic disorder""]",,A somatoform disorder that involves an excessive concern about and preoccupation with a perceived defect in his or her physical features (body image).,false,,,http://purl.obolibrary.org/obo/DOID_4737,,,,,,,,A somatoform disorder that involves an excessive concern about and preoccupation with a perceived defect in his or her physical features (body image).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060163,lschriml,2011-09-07T01:38:34Z,,,dysmorphic syndrome|dysmorphophobia|body dysmorphia,,disease_ontology,,DOID:0060163,,,,,,,,,,,,,,,,,,,body dysmorphic disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060167,"[""seasonal affective disorder""]",,A mental depression that involves presentation of depressive symptoms only during a specific season of the year.,false,,,http://purl.obolibrary.org/obo/DOID_1596,,,,,,,,A mental depression that involves presentation of depressive symptoms only during a specific season of the year.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060167,lschriml,2011-09-09T02:53:18Z,,,winter depression,,disease_ontology,,DOID:0060167,,,,,,,,,,,,,,,,,,,seasonal affective disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060161,"[""Kennedy's disease""]",,A spinal muscular dystrophy that has_material_basis_in an X-linked recessive expansion of CAG triplet repeats (glutamine) in exon 1 of AR gene encoding the androgen receptor.,false,,,http://purl.obolibrary.org/obo/DOID_12377,,,,,,,,A spinal muscular dystrophy that has_material_basis_in an X-linked recessive expansion of CAG triplet repeats (glutamine) in exon 1 of AR gene encoding the androgen receptor.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060161,lschriml,2011-08-29T01:31:03Z,,OMIM:313200|UMLS_CUI:C1839259|NCI:C85233|MESH:D055534|SNOMEDCT_US_2016_03_01:230253001,SBMA|X-Linked Bulbo-Spinal Atrophy|Kennedy disease|spinal bulbar muscular atrophy|Spinobulbar Muscular Atrophy|X-linked Spinal and Bulbar Muscular Atrophy,,disease_ontology,,DOID:0060161,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,Kennedy's disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060164,"[""pain disorder""]",,"A somatoform disorder that involves chronic pain in one or more areas, and is thought to be caused by psychological stress.",false,,,http://purl.obolibrary.org/obo/DOID_4737,,,,,,,,"A somatoform disorder that involves chronic pain in one or more areas, and is thought to be caused by psychological stress.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060164,lschriml,2011-09-07T01:42:46Z,,,,,disease_ontology,,DOID:0060164,,,,,,,,,,,,,,,,,,,pain disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100399,"[""Olfactory receptor 51I1""]",,"An olfactory receptor 51I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H343] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 51I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H343] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100399,,,,https://pharos.nih.gov/idg/targets/Q9H343,,,,,,,,,,,,,OR51I1,,,Q9H343,,,,,,,,Olfactory receptor 51I1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_18,"[""urinary system disease""]",,"A disease of anatomical entity that is located_in kidney, ureter, bladder and urethra.",false,,,http://purl.obolibrary.org/obo/DOID_7,,,,,,,,"A disease of anatomical entity that is located_in kidney, ureter, bladder and urethra.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:18,,,DOID:579,UMLS_CUI:C1335051|NCI:C27599,urinary tract disease|Non-neoplastic urinary tract disease,,disease_ontology,,DOID:18,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,urinary system disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_182,"[""calcinosis""]",,A calcium metabolism disease that is the result of the formation of calcium deposits in any soft tissue.,false,,,http://purl.obolibrary.org/obo/DOID_10575,,,,,,,,A calcium metabolism disease that is the result of the formation of calcium deposits in any soft tissue.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:182,,,,MESH:D002114|SNOMEDCT_US_2016_03_01:190863003|UMLS_CUI:C0006663|SNOMEDCT_US_2016_03_01:237881004|NCI:C3672|SNOMEDCT_US_2016_03_01:6595006,pathologic calcification|Pathologically calcified structure,,disease_ontology,,DOID:182,,,,,,,,,,,,,,,,,,,calcinosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_184,"[""bone cancer""]",,A connective tissue cancer that is located_in bone and is characterized by uncontrolled cellular proliferation that destroys normal bone tissue.,false,,,http://purl.obolibrary.org/obo/DOID_201,,,,,,,,A connective tissue cancer that is located_in bone and is characterized by uncontrolled cellular proliferation that destroys normal bone tissue.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:184,,,DOID:3348,SNOMEDCT_US_2016_03_01:126537000|MESH:D001859|CSP:2019-1041|SNOMEDCT_US_2016_03_01:115239009|SNOMEDCT_US_2016_03_01:240201007|UMLS_CUI:C0005967|NCI:C9343,malignant bone tumour|bone tumour|osseous tumor|CA - bone cancer|malignant osseous tumor|neoplasm of bone|bone neoplasm|malignant neoplasm of bone|malignant bone neoplasm,,disease_ontology,,DOID:184,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,bone cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4379,"[""nut allergy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4379,,,,SNOMEDCT_US_2016_03_01:395654004|MESH:D021184|SNOMEDCT_US_2016_03_01:91934008|UMLS_CUI:C0577620,allergy to nuts|nut allergic reaction,,disease_ontology,,DOID:4379,,,,,,,,,,,,,,,,,,,nut allergy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003139,"[""UM-SCC-12 cell""]",,Head and neck squamous cell carcinoma (HNSCC) cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002709,,,,,,,,Head and neck squamous cell carcinoma (HNSCC) cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003139,,,,,,,BrendaTissueOBO,SCC-12 cell|SCC12 cell|UMSCC-12 cell,BTO:0003139,,,,,,,,,,,,,,,,,,,UM-SCC-12 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200067,"[""CYSLTR1 gene""]",,"A cysteinyl leukotriene receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y271] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400033,,,,,,,,"A cysteinyl leukotriene receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y271] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200067,,,,,,,,,,,,,,,,10800,CYSLTR1,CYSLT1,,,,,,,,,,CYSLTR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200314,"[""MINK1 gene""]",,"This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400288,,,,,,,,"This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200314,,,,,,,,,,,,,,,,50488,MINK1,B55|MAP4K6|MINK,,,,,,,,,,MINK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100204,"[""Camp-dependent protein kinase catalytic subunit alpha""]",,"A cAMP-dependent protein kinase catalytic subunit alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P17612] |camp-dependent protein kinase catalytic subunit alpha (PKAC-alpha)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300169,,,,,,,,"A cAMP-dependent protein kinase catalytic subunit alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P17612] |camp-dependent protein kinase catalytic subunit alpha (PKAC-alpha)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100204,,,,https://pharos.nih.gov/idg/targets/P17612,,,,,,,,,,,,,PRKACA,PKACA,,P17612,,,,,,,,Camp-dependent protein kinase catalytic subunit alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200626,"[""OR5H2 gene""]",,"An olfactory receptor 5H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGV7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGV7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200626,,,,,,,,,,,,,,,,79310,OR5H2,,,,,,,,,,,OR5H2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060611,"[""abdominal obesity-metabolic syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_654,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060611,,,,OMIM:PS605552,,,,,DOID:0060611,,,,,,,,,,,,,,,,,,,abdominal obesity-metabolic syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2452,"[""thrombophilia""]",,OMIM mapping confirmed by DO. [LS].,false,,,http://purl.obolibrary.org/obo/DOID_1247,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2452,,,,OMIM:614486|UMLS_CUI:C0398623|SNOMEDCT_US_2016_03_01:76612001|SNOMEDCT_US_2016_03_01:234467004|SNOMEDCT_US_2016_03_01:191302007|ICD10CM:D68.59|NCI:C84479|OMIM:188050|MESH:D019851,hypercoagulability state,,disease_ontology,,DOID:2452,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,thrombophilia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1588,"[""thrombocytopenia""]",,A blood platelet disease characterized by low a platelet count in the blood.,false,,,http://purl.obolibrary.org/obo/DOID_2218,,,,,,,,A blood platelet disease characterized by low a platelet count in the blood.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1588,,,,SNOMEDCT_US_2016_03_01:154827000|ICD9CM:287.5|OMIM:612004|OMIM:313900|SNOMEDCT_US_2016_03_01:142969008|MESH:D013921|ORDO:852|UMLS_CUI:C0040034|SNOMEDCT_US_2016_03_01:302215000|SNOMEDCT_US_2016_03_01:70786006|SNOMEDCT_US_2016_03_01:165556002|NCI:C3408|OMIM:273900|OMIM:300367|ICD10CM:D69.6|SNOMEDCT_US_2016_03_01:415116008|OMIM:188000|SNOMEDCT_US_2016_03_01:191326009,,,disease_ontology,,DOID:1588,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,thrombocytopenia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4706,"[""infratentorial cancer""]",,A brain cancer that is located_in the infratentorial region.,false,,,http://purl.obolibrary.org/obo/DOID_1319,,,,,,,,A brain cancer that is located_in the infratentorial region.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4706,,,DOID:4789,UMLS_CUI:C0021432|UMLS_CUI:C0751593|NCI:C3139|ICD10CM:C71.7|MESH:D015192|NCI:C4966,"brain neoplasm, Infratentorial|malignant Infratentorial tumors",,disease_ontology,,DOID:4706,,,,,,,,,,,,,,,,,,,infratentorial cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100462,"[""Ribosomal protein s6 kinase-like 1""]",,"A ribosomal protein S6 kinase-like 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y6S9] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300179,,,,,,,,"A ribosomal protein S6 kinase-like 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y6S9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100462,,,,https://pharos.nih.gov/idg/targets/Q9Y6S9,,,,,,,,,,,,,RPS6KL1,,,Q9Y6S9,,,,,,,,Ribosomal protein s6 kinase-like 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300275,"[""Meta subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300174,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300275,,,,,,,,,,,,,,,,,,,,,,,,,,,,Meta subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001462,"[""bladder wall""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001462,,,,,,,BrendaTissueOBO,,BTO:0001462,,,,,,,,,,,,,,,,,,,bladder wall,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200627,"[""UCKL1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200627,,,,,,,,,,,,,,,,,,,,,,,,,,,,UCKL1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001325,"[""superior cervical ganglion""]",,"The uppermost ganglion on the sympathetic trunk, lying behind the internal carotid artery and in front of the second and third cervical vertebrae; it gives rise to postganglionic fibers to the heart via cervical cardiac nerves, to the pharyngeal plexus and thence to the larynx and pharynx, and to the head via the external and internal carotid plexuses.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000113,,,,,,,,"The uppermost ganglion on the sympathetic trunk, lying behind the internal carotid artery and in front of the second and third cervical vertebrae; it gives rise to postganglionic fibers to the heart via cervical cardiac nerves, to the pharyngeal plexus and thence to the larynx and pharynx, and to the head via the external and internal carotid plexuses.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001325,,,,,,,BrendaTissueOBO,ganglion cervicale superius,BTO:0001325,,,,,,,,,,,,,,,,,,,superior cervical ganglion,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11049,"[""meconium aspiration syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_850,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11049,,,,ICD10CM:P24.00|UMLS_CUI:C0025048|SNOMEDCT_US_2016_03_01:14608006|SNOMEDCT_US_2016_03_01:206292002|ICD10CM:P24.01|SNOMEDCT_US_2016_03_01:157110000|NCI:C87093|MESH:D008471|ICD10CM:P24.0|SNOMEDCT_US_2016_03_01:85779008|SNOMEDCT_US_2016_03_01:278927005,Neonatal aspiration of meconium|meconium aspiration,,disease_ontology,,DOID:11049,,,,,,,,,,,,,,,,,,,meconium aspiration syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11044,"[""gastroschisis""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0080015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11044,,,,OMIM:230750|SNOMEDCT_US_2016_03_01:72951007|ICD9CM:756.73|MESH:D020139|ICD10CM:Q79.3|UMLS_CUI:C0265706|NCI:C84725,,,disease_ontology,,DOID:11044,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,gastroschisis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4677,"[""keratitis""]",,A corneal disease that is characterized by inflammation of the cornea.,false,,,http://purl.obolibrary.org/obo/DOID_10124,,,,,,,,A corneal disease that is characterized by inflammation of the cornea.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4677,,,,SNOMEDCT_US_2016_03_01:155151002|UMLS_CUI:C0022568|ICD10CM:H16|MESH:D007634|SNOMEDCT_US_2016_03_01:193793001|SNOMEDCT_US_2016_03_01:193757003|ICD9CM:370|SNOMEDCT_US_2016_03_01:267730006|SNOMEDCT_US_2016_03_01:155155006|ICD10CM:H16.9|NCI:C26805|SNOMEDCT_US_2016_03_01:5888003|ICD9CM:370.9,,,disease_ontology,,DOID:4677,,,,,,,,,,,,,,,,,,,keratitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400426,"[""KCNJ15 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400426,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ15 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100015,"[""Adenosine receptor a2b""]",,"An adenosine receptor A2b that is encoded in the genome of human. [PRO:WCB, UniProtKB:P29275] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300018,,,,,,,,"An adenosine receptor A2b that is encoded in the genome of human. [PRO:WCB, UniProtKB:P29275] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100015,,,,https://pharos.nih.gov/idg/targets/P29275,,,,,,,,,,,,,ADORA2B,,,P29275,,,,,,,,Adenosine receptor a2b,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9986,"[""orbit lymphoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4143,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9986,,,,UMLS_CUI:C0271333|NCI:C6244|MESH:C537131|SNOMEDCT_US_2016_03_01:13048006,Lymphoma of the orbit,,disease_ontology,,DOID:9986,,,,,,,,,,,,,,,,,,,orbit lymphoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000773,"[""lymphoblastoid cell line""]",,"Human cell line from tissue infected with Epstein-Barr virus, resembling a lymphoblast.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Human cell line from tissue infected with Epstein-Barr virus, resembling a lymphoblast.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000773,,,,,,,BrendaTissueOBO,lymphoblastoid cell,BTO:0000773,,,,,,,,,,,,,,,,,,,lymphoblastoid cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000351,"[""THR348 in YES""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000351,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR348 in YES,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100419,"[""Serine/threonine-protein kinase pim-3""]",,"A serine/threonine-protein kinase Pim-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86V86] |serine/threonine-protein kinase pim-3 (PIM3)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300207,,,,,,,,"A serine/threonine-protein kinase Pim-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86V86] |serine/threonine-protein kinase pim-3 (PIM3)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100419,,,,https://pharos.nih.gov/idg/targets/Q86V86,,,,,,,,,,,,,PIM3,,,Q86V86,,,,,,,,Serine/threonine-protein kinase pim-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2994,"[""germ cell cancer""]",,A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from germ cells.,false,,,http://purl.obolibrary.org/obo/DOID_0050687,,,,,,,,A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from germ cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2994,,,DOID:2157,SNOMEDCT_US_2016_03_01:28307001|SNOMEDCT_US_2016_03_01:402878003|UMLS_CUI:C0205851|SNOMEDCT_US_2016_03_01:189854008|SNOMEDCT_US_2016_03_01:302853003|NCI:C3708|SNOMEDCT_US_2016_03_01:115233005|SNOMEDCT_US_2016_03_01:189839002|MESH:D009373,malignant tumor of the germ cell,,disease_ontology,germ cell neoplasm|germ cell tumour,DOID:2994,,,,,,,,,,,,,,,,,,,germ cell cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300036,"[""Corticotropin-releasing factor receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300003,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300036,,,,,,,,,,,,,,,,,,,,,,,,,,,,Corticotropin-releasing factor receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1790,"[""malignant mesothelioma""]",,A cell type cancer that has_material_basis_in mesothelial tissue.,false,,,http://purl.obolibrary.org/obo/DOID_0050687,,,,,,,,A cell type cancer that has_material_basis_in mesothelial tissue.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1790,,,DOID:7434|DOID:6965|DOID:4487,MESH:C562839|UMLS_CUI:C0392400|UMLS_CUI:C1332338|NCI:C8420|UMLS_CUI:C0278752|SNOMEDCT_US_2016_03_01:62064005|NCI:C4456|NCI:C27926|OMIM:156240|UMLS_CUI:C0345967|NCI:C7865,malignant tumor of Mesothelium|advanced malignant mesothelioma|Diffuse malignant Mesothelioma|asbestos-related malignant mesothelioma,,disease_ontology,,DOID:1790,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,malignant mesothelioma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100096,"[""Cation channel sperm-associated protein 4""]",,"A cation channel sperm-associated protein 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7RTX7] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300345,,,,,,,,"A cation channel sperm-associated protein 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7RTX7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100096,,,,https://pharos.nih.gov/idg/targets/Q7RTX7,,,,,,,,,,,,,CATSPER4,,,Q7RTX7,,,,,,,,Cation channel sperm-associated protein 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003508,"[""RPMI-7951 cell""]",,Human malignant melanoma cell line; established from an involved lymph node of an 18-year-old Caucasian woman with malignant melanoma in 1971.,false,,,http://purl.obolibrary.org/obo/BTO_0000849|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human malignant melanoma cell line; established from an involved lymph node of an 18-year-old Caucasian woman with malignant melanoma in 1971.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003508,,,,,,,BrendaTissueOBO,RPMI7951 cell,BTO:0003508,,,,,,,,,,,,,,,,,,,RPMI-7951 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000195,"[""INSRR kinase domain""]",,Insulin receptor-related receptor; INSRR; IRR,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Insulin receptor-related receptor; INSRR; IRR,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000195,,,,,,,,,,,,,,,,,,,200198,,,,,,,,,INSRR kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200192,"[""IRAK3 gene""]",,"This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400166,,,,,,,,"This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200192,,,,,,,,,,,,,,,,11213,IRAK3,,,,,,,,,,,IRAK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200285,"[""MAP3K3 gene""]",,"This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400186,,,,,,,,"This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200285,,,,,,,,,,,,,,,,4215,MAP3K3,MAPKKK3|MEKK3,,,,,,,,,,MAP3K3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100330,"[""Mixed lineage kinase domain-like protein""]",,"A mixed lineage kinase domain-like protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NB16] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300192,,,,,,,,"A mixed lineage kinase domain-like protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NB16] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100330,,,,https://pharos.nih.gov/idg/targets/Q8NB16,,,,,,,,,,,,,MLKL,,,Q8NB16,,,,,,,,Mixed lineage kinase domain-like protein,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_16349,"[""L-citrulline""]","N5-(Aminocarbonyl)ornithine|175.096|alpha-amino-delta-ureidovaleric acid|N[C@@H](CCCNC(N)=O)C(O)=O|delta-ureidonorvaline|(S)-2-Amino-5-ureidopentanoic acid|C6H13N3O3|Cit|N(delta)-carbamylornithine|N(5)-(aminocarbonyl)-L-ornithine|2-Amino-5-ureidovaleric acid|175.18584|RHGKLRLOHDJJDR-BYPYZUCNSA-N|InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1|L-2-Amino-5-ureidovaleric acid|Citrulline|0|N5-carbamoylornithine|CITRULLINE",The L-enantiomer of citrulline.,false,,,http://purl.obolibrary.org/obo/CHEBI_33709,,,,,,,PMID:11862757|KNApSAcK:C00001348|PDBeChem:CIR|YMDB:YMDB00060|PMID:22402472|PMID:22388927|Drug_Central:3103|PMID:22402328|PMID:22119809|PMID:21915076|Wikipedia:Citrulline|Beilstein:6055157|Gmelin:774677|MetaCyc:L-CITRULLINE|HMDB:HMDB00904|PMID:22512552|PMID:22387109|KEGG:D07706|CAS:372-75-8|DrugBank:DB00155|PMID:22345866|ECMDB:ECMDB00904|Beilstein:1725416|PMID:21955999|KEGG:C00327|PMID:22348173|PMID:19173225|PMID:17190852|PMID:21067832|PMID:18022291|Reaxys:1725416,The L-enantiomer of citrulline.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:41489|CHEBI:21257|CHEBI:6203|CHEBI:13092,,N(5)-carbamoyl-L-ornithine|L-citrulline|L-Citrulline|(2S)-2-amino-5-(carbamoylamino)pentanoic acid,,chebi_ontology,"N5-(Aminocarbonyl)ornithine|175.096|alpha-amino-delta-ureidovaleric acid|N[C@@H](CCCNC(N)=O)C(O)=O|delta-ureidonorvaline|(S)-2-Amino-5-ureidopentanoic acid|C6H13N3O3|Cit|N(delta)-carbamylornithine|N(5)-(aminocarbonyl)-L-ornithine|2-Amino-5-ureidovaleric acid|175.18584|RHGKLRLOHDJJDR-BYPYZUCNSA-N|InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1|L-2-Amino-5-ureidovaleric acid|Citrulline|0|N5-carbamoylornithine|CITRULLINE",,,CHEBI:16349,,,,,,,,,,,,,,,,,,,,,,,CHEBI:16349,,,,,L-citrulline,,CHEBI:16349,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005590,"[""cervical adenocarcinoma cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0001967|http://purl.obolibrary.org/obo/BTO_0000167|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005590,Marion,2014-03-06T10:42:29Z,,,,,BrendaTissueOBO,,BTO:0005590,,,,,,,,,,,,,,,,,,,cervical adenocarcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100313,"[""Hepatocyte growth factor receptor""]",,"hepatocyte growth factor receptor (MET)  with  no mutation  in a nonphosphorylated state|hepatocyte growth factor receptor (MET(M1250T))  with  mutation T1250 in MET(M1250T) in a nonphosphorylated state|hepatocyte growth factor receptor (MET(Y1235D))  with  mutation D1235 in MET(Y1235D) in a nonphosphorylated state|A hepatocyte growth factor receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08581] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300190,,,,,,,,"hepatocyte growth factor receptor (MET)  with  no mutation  in a nonphosphorylated state|hepatocyte growth factor receptor (MET(M1250T))  with  mutation T1250 in MET(M1250T) in a nonphosphorylated state|hepatocyte growth factor receptor (MET(Y1235D))  with  mutation D1235 in MET(Y1235D) in a nonphosphorylated state|A hepatocyte growth factor receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08581] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100313,,,,https://pharos.nih.gov/idg/targets/P08581,,,,,,,,,,,,,MET,,,P08581,,,,,,,,Hepatocyte growth factor receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300199,"[""SCY1 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300199,,,,,,,,,,,,,,,,,,,,,,,,,,,,SCY1 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400193,"[""MOS family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400193,,,,,,,,,,,,,,,,,,,,,,,,,,,,MOS family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000048,"[""BIKE kinase domain""]",,BMP2 inducible kinase; BIKE; BMP2K; DKFZp434K0614; DKFZp434P0116; HRIHFB2017,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,BMP2 inducible kinase; BIKE; BMP2K; DKFZp434K0614; DKFZp434P0116; HRIHFB2017,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000048,,,,,,,,,,,,,,,,,,,200048,,,,,,,,,BIKE kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003221,"[""corneal cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003221,,,,,,,BrendaTissueOBO,,BTO:0003221,,,,,,,,,,,,,,,,,,,corneal cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100224,"[""Potassium channel subfamily k member 15""]",,"A potassium channel subfamily K member 15 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H427] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300359,,,,,,,,"A potassium channel subfamily K member 15 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H427] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100224,,,,https://pharos.nih.gov/idg/targets/Q9H427,,,,,,,,,,,,,KCNK15,TASK5,,Q9H427,,,,,,,,Potassium channel subfamily k member 15,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200043,"[""BDKRB2 gene""]",,"A B2 bradykinin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30411] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400025,,,,,,,,"A B2 bradykinin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30411] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200043,,,,,,,,,,,,,,,,624,BDKRB2,BKR2,,,,,,,,,,BDKRB2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000121,"[""Des-Br-neuropeptide B-29""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000121,,,,,,,,,,,,,,,,,,,,,,,,,,,,Des-Br-neuropeptide B-29,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200190,"[""GPR32 gene""]",,"A G-protein coupled receptor 32 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O75388] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 32 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O75388] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200190,,,,,,,,,,,,,,,,2854,GPR32,,,,,,,,,,,GPR32 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300079,"[""Proteinase-activated receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300079,,,,,,,,,,,,,,,,,,,,,,,,,,,,Proteinase-activated receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400396,"[""ClC-2/CLCN2 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400341,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400396,,,,,,,,,,,,,,,,,,,,,,,,,,,,ClC-2/CLCN2 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2718,"[""hemopneumothorax""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1673,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2718,,,,UMLS_CUI:C0019077|MESH:D006468|SNOMEDCT_US_2016_03_01:16632002|ICD10CM:J94.2,,,disease_ontology,,DOID:2718,,,,,,,,,,,,,,,,,,,hemopneumothorax,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2297,"[""leptospirosis""]",,"A primary bacterial infectious disease that involves systemic infection, has_material_basis_in Leptospira, which is transmitted_by contact with water, food, or soil containing urine from the infected animals. The infection has_symptom jaundice, has_symptom chills, has_symptom fever, has_symptom muscle pain, and has_symptom hepatomegaly.",false,,,http://purl.obolibrary.org/obo/DOID_37|http://purl.obolibrary.org/obo/DOID_0050338,,,,,,,,"A primary bacterial infectious disease that involves systemic infection, has_material_basis_in Leptospira, which is transmitted_by contact with water, food, or soil containing urine from the infected animals. The infection has_symptom jaundice, has_symptom chills, has_symptom fever, has_symptom muscle pain, and has_symptom hepatomegaly.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2297,,,DOID:11348,ICD10CM:A27.0|SNOMEDCT_US_2016_03_01:398067003|SNOMEDCT_US_2016_03_01:187311001|SNOMEDCT_US_2016_03_01:69092001|NCI:C84825|ICD10CM:A27|SNOMEDCT_US_2016_03_01:398222003|SNOMEDCT_US_2016_03_01:186959001|SNOMEDCT_US_2016_03_01:186958009|SNOMEDCT_US_2016_03_01:186954006|SNOMEDCT_US_2016_03_01:266213004|SNOMEDCT_US_2016_03_01:77377001|ICD10CM:A27.9|ICD9CM:100|MESH:D007922|SNOMEDCT_US_2016_03_01:186953000|SNOMEDCT_US_2016_03_01:154391003|UMLS_CUI:C0023364|SNOMEDCT_US_2016_03_01:50574007|UMLS_CUI:C0043102|ICD9CM:100.0|ICD9CM:100.9|MESH:D014895,nanukayami fever|spirochetal jaundice|Rat Catcher's Yellows|Weil's disease|Fort Bragg fever|Leptospirosis icterohaemorrhagica,,disease_ontology,,DOID:2297,http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease|http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,leptospirosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8295,"[""scabies""]",,"A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite Sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades.",false,,,http://purl.obolibrary.org/obo/DOID_7894,,,,,,,,"A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite Sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8295,,,,SNOMEDCT_US_2016_03_01:266224002|NCI:C34998|ICD9CM:133.0|MESH:D012532|SNOMEDCT_US_2016_03_01:187215008|ICD10CM:B86|SNOMEDCT_US_2016_03_01:67172004|UMLS_CUI:C0036262|SNOMEDCT_US_2016_03_01:154422001|SNOMEDCT_US_2016_03_01:128869009,Infestation by Sarcoptes scabiei|Infestation by Sarcoptes scabiei var hominis|Sarcoptic itch,,disease_ontology,,DOID:8295,,,,,,,,,,,,,,,,,,,scabies,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200610,"[""OR4X2 gene""]",,"An olfactory receptor 4X2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4X2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200610,,,,,,,,,,,,,,,,119764,OR4X2,,,,,,,,,,,OR4X2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200032,"[""ADRA2C gene""]",,"An alpha-2C adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P18825] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400093,,,,,,,,"An alpha-2C adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P18825] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200032,,,,,,,,,,,,,,,,152,ADRA2C,ADRA2L2|ADRA2RL2,,,,,,,,,,ADRA2C gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200442,"[""PTK6 gene""]",,"The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400132,,,,,,,,"The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200442,,,,,,,,,,,,,,,,5753,PTK6,BRK,,,,,,,,,,PTK6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200295,"[""SCN4A gene""]",,"Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is expressed in skeletal muscle, and mutations in this gene have been linked to several myotonia and periodic paralysis disorders. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400469,,,,,,,,"Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is expressed in skeletal muscle, and mutations in this gene have been linked to several myotonia and periodic paralysis disorders. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200295,,,,,,,,,,,,,,,,6329,SCN4A,,,,,,,,,,,SCN4A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100115,"[""Gamma-aminobutyric acid receptor subunit beta-3""]",,"A gamma-aminobutyric acid receptor subunit beta-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P28472] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300514,,,,,,,,"A gamma-aminobutyric acid receptor subunit beta-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P28472] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100115,,,,https://pharos.nih.gov/idg/targets/P28472,,,,,,,,,,,,,GABRB3,,,P28472,,,,,,,,Gamma-aminobutyric acid receptor subunit beta-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_9937,"[""vasopressin""]",arginine vasopressin|argipressin|beta-Hypophamine|VP|Inyectable de vasopresina|Vasopressini injectio|C46H65N15O12S2.C46H65N13O12S2|Antidiuretic hormone|AVP|ADH|Solute injectable de vasopressine,"A family of cyclic nonapeptide hormones found in most mammals. Synthesised in the hypothalamus and stored in the post-pituitary, vasopressins play a key role in homeostasis, particularly in regulating the body's water content. Together with the similar neuropeptide oxytocin, they are believed to influence social cognition and behaviour.",false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:D00101|PMID:18988842|KEGG:C00840|PMID:20445498|CAS:11000-17-2,"A family of cyclic nonapeptide hormones found in most mammals. Synthesised in the hypothalamus and stored in the post-pituitary, vasopressins play a key role in homeostasis, particularly in regulating the body's water content. Together with the similar neuropeptide oxytocin, they are believed to influence social cognition and behaviour.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Vasopressin,,chebi_ontology,arginine vasopressin|argipressin|beta-Hypophamine|VP|Inyectable de vasopresina|Vasopressini injectio|C46H65N15O12S2.C46H65N13O12S2|Antidiuretic hormone|AVP|ADH|Solute injectable de vasopressine,,,CHEBI:9937,,,,,,,,,,,,,,,,,,,,,,,CHEBI:9937,,,,,vasopressin,,CHEBI:9937,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200164,"[""KCNJ9 gene""]",,"Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It associates with another G-protein-activated potassium channel to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400435,,,,,,,,"Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It associates with another G-protein-activated potassium channel to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200164,,,,,,,,,,,,,,,,3765,KCNJ9,GIRK3,,,,,,,,,,KCNJ9 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/UBERON_0001969,"[""blood plasma""]",plasma|portion of plasma|portion of blood plasma,"Body substance in liquid state contained in the lumen of arterial and venous trees, blood capillary and the cardiac chambers; constitutes the liquid phase of blood.[FMA]",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,http://en.wikipedia.org/wiki/Blood_plasma|http://linkedlifedata.com/resource/umls/id/C0032105|UMLS:C0032105|EFO:0001905|BTO:0000131|OpenCyc:Mx4rEg4ZYrIbEduAAAAOpmP6tw|MA:0002501|GAID:1178|MESH:A12.207.152.693|CALOHA:TS-0800|MAT:0000052|ncithesaurus:Plasma|MIAA:0000052|FMA:62970,"Body substance in liquid state contained in the lumen of arterial and venous trees, blood capillary and the cardiac chambers; constitutes the liquid phase of blood.[FMA]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,plasma|portion of plasma|portion of blood plasma,,uberon,,,,,,,,,,,,,,,,,,,,,,,,,,,UBERON:0001969,,,,,blood plasma,,UBERON:0001969,,http://purl.obolibrary.org/obo/uberon.owl,http://purl.obolibrary.org/obo/uberon/core#efo_slim|http://purl.obolibrary.org/obo/uberon/core#uberon_slim,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001938,"[""U2-OS cell""]",,Human osteosarcoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000407,,,,,,,,Human osteosarcoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001938,,,,,,,BrendaTissueOBO,U2 osteosarcoma cell|U2OS cell,BTO:0001938,,,,,,,,,,,,,,,,,,,U2-OS cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_15428,"[""Glycine""]","Glyzin|NCC(O)=O|2-aminoethanoic acid|InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)|Glycolixir|Amino-Acetic acid|Gyn-Hydralin|G|Glycocoll|Leimzucker|Hgly|H2N-CH2-COOH|2-Aminoacetate|Aminoessigsaeure|C2H5NO2|Aminoacetate|DHMQDGOQFOQNFH-UHFFFAOYSA-N|Glicoamin|Glycosthene|Gly|aminoethanoic acid|Aminoethanoate|Padil|Glykokoll|Amino-Acetate|2-aminoacetic acid|Aminoacetic acid|Aciport|Glycin","
The simplest (and the only achiral) proteinogenic amino acid, with a hydrogen atom as its side chain.
",false,,,http://purl.obolibrary.org/obo/CHEBI_33709,,,,,,,CiteXplore:17154252|KNApSAcK:C00001361|CiteXplore:12097436|CiteXplore:15911239|CiteXplore:16998855|CiteXplore:19212411|CiteXplore:19028609|PDBeChem:GLY|CiteXplore:12631515|CiteXplore:17383967|KEGG DRUG:D00011|CiteXplore:16417482|CiteXplore:9639330|CiteXplore:19916621|Reaxys:635782|CiteXplore:19924257|CiteXplore:19259987|CiteXplore:16105183|CiteXplore:19544666|YMDB:YMDB00016|CiteXplore:12921899|CiteXplore:19449910|ChemIDplus:56-40-6|CiteXplore:18840508|CiteXplore:16390611|CiteXplore:22293292|CiteXplore:22234938|CiteXplore:19120667|CiteXplore:11159884|Wikipedia:Glycine|CiteXplore:6696735|KEGG COMPOUND:56-40-6|CiteXplore:14622583|CiteXplore:22401276|CiteXplore:16444815|CiteXplore:8456092|CiteXplore:11806864|CiteXplore:8888048|CiteXplore:16664855|CiteXplore:16151895|CiteXplore:2026685|CiteXplore:18816054|CiteXplore:11569574|CiteXplore:22044190|CiteXplore:21751272|CiteXplore:16686720|CiteXplore:11019925|NIST Chemistry WebBook:56-40-6|CiteXplore:24023812|CiteXplore:16918424|CiteXplore:22264337|CiteXplore:15710237|CiteXplore:6321058|CiteXplore:12834252|CiteXplore:16986325|CiteXplore:19526731|CiteXplore:15388434|CiteXplore:12297216|CiteXplore:15780050|CiteXplore:10930630|CiteXplore:11174716|CiteXplore:22434786|CiteXplore:12770151|CiteXplore:12754315|CiteXplore:11542461|MetaCyc:GLY|DrugBank:DB00145|CiteXplore:18396796|CiteXplore:6198473|CiteXplore:16453318|CiteXplore:22411374|CiteXplore:18440992|CiteXplore:19738917|Gmelin:1808|CiteXplore:18079355|CiteXplore:15331688|CiteXplore:17582620|CiteXplore:17970719|Beilstein:635782|ECMDB:ECMDB00123|KEGG COMPOUND:C00037|CiteXplore:22079563|CiteXplore:16214212|CiteXplore:16901953|CiteXplore:18593588|CiteXplore:14992292|HMDB:HMDB00123,"
The simplest (and the only achiral) proteinogenic amino acid, with a hydrogen atom as its side chain.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:24368|CHEBI:10792|CHEBI:5460|CHEBI:14344|CHEBI:42964,,Glycine|glycine|GLYCINE|aminoacetic acid,,chebi_ontology,"Glyzin|NCC(O)=O|2-aminoethanoic acid|InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)|Glycolixir|Amino-Acetic acid|Gyn-Hydralin|G|Glycocoll|Leimzucker|Hgly|H2N-CH2-COOH|2-Aminoacetate|Aminoessigsaeure|C2H5NO2|Aminoacetate|DHMQDGOQFOQNFH-UHFFFAOYSA-N|Glicoamin|Glycosthene|Gly|aminoethanoic acid|Aminoethanoate|Padil|Glykokoll|Amino-Acetate|2-aminoacetic acid|Aminoacetic acid|Aciport|Glycin",,,CHEBI:15428,,,,,,,,,,,,,,,,,,,,,,,CHEBI:15428,,,,,Glycine|glycine,,CHEBI:15428,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050175,"[""tick-borne encephalitis""]",,"A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Tick-borne encephalitis virus, which is transmitted_by Ixodes ticks. The infection has_symptom drowsiness, has_symptom confusion, has_symptom sensory disturbances, and has_symptom paralysis.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Tick-borne encephalitis virus, which is transmitted_by Ixodes ticks. The infection has_symptom drowsiness, has_symptom confusion, has_symptom sensory disturbances, and has_symptom paralysis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050175,,,DOID:10252|DOID:0050176|DOID:10251,ICD9CM:063.2|UMLS_CUI:C0014054|SNOMEDCT_US_2016_03_01:16901001|ICD10CM:A84.1|MESH:D004675,Far Eastern TBE|Western European tick-borne encephalitis|Russian spring-summer encephalitis|Taiga encephalitis|Siberian tick-borne encephalitis|Central European encephalitis|west-Siberian encephalitis,,disease_ontology,,DOID:0050175,http://purl.obolibrary.org/obo/doid#tick-borne_infectious_disease,,,,,,,,,,,,,,,,,,tick-borne encephalitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050177,"[""monogenic disease""]",,"A genetic disease that is the result of one or more abnormal alleles and may be dominant (a single copy of the abnormal allele is sufficient to give rise to the disease), semi-dominant, or recessive (requiring both copies of the gene to have an abnormal allele).",false,,,http://purl.obolibrary.org/obo/DOID_630,,,,,,,,"A genetic disease that is the result of one or more abnormal alleles and may be dominant (a single copy of the abnormal allele is sufficient to give rise to the disease), semi-dominant, or recessive (requiring both copies of the gene to have an abnormal allele).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050177,,,,,,,disease_ontology,,DOID:0050177,,,,,,,,,,,,,,,,,,,monogenic disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400246,"[""STKR Type 1 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400119,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400246,,,,,,,,,,,,,,,,,,,,,,,,,,,,STKR Type 1 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000553,"[""peripheral blood""]",,Blood circulating throughout the body.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Blood circulating throughout the body.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000553,,,,,,,BrendaTissueOBO,,BTO:0000553,,,,,,,,,,,,,,,,,,,peripheral blood,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000122,"[""EGFR(G719C) kinase domain""]",,"Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000122,,,,,,,,,,,,,,,,,,,200124,,,,,,,,,EGFR(G719C) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000052,"[""BMPR2 kinase domain""]",,"Bone morphogenetic protein receptor, type II (serine/threonine kinase); BMPR2; BMPR3; BMPR-II; BMR2; BRK-3; FLJ41585; FLJ76945; PPH1; T-ALK",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Bone morphogenetic protein receptor, type II (serine/threonine kinase); BMPR2; BMPR3; BMPR-II; BMR2; BRK-3; FLJ41585; FLJ76945; PPH1; T-ALK",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000052,,,,,,,,,,,,,,,,,,,200052,,,,,,,,,BMPR2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391032,"[""Carbohydrate kinase PfkB family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300325,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391032,,,,,,,,,,,,,,,,,,,,,,,,,,,,Carbohydrate kinase PfkB family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300484,"[""TrpV subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300360,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300484,,,,,,,,,,,,,,,,,,,,,,,,,,,,TrpV subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200091,"[""EMR3 gene""]",,"An EGF-like module-containing mucin-like hormone receptor-like 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BY15] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,"An EGF-like module-containing mucin-like hormone receptor-like 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BY15] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200091,,,,,,,,,,,,,,,,84658,EMR3,,,,,,,,,,,EMR3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200273,"[""PANX3 gene""]",,"The protein encoded by this gene belongs to the innexin family. Innexin family members are known to be the structural components of gap junctions. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400365,,,,,,,,"The protein encoded by this gene belongs to the innexin family. Innexin family members are known to be the structural components of gap junctions. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200273,,,,,,,,,,,,,,,,116337,PANX3,,,,,,,,,,,PANX3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8947,"[""diabetic retinopathy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2462,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8947,,,,ICD9CM:362.0|SNOMEDCT_US_2016_03_01:141196007|NCI:C34538|SNOMEDCT_US_2016_03_01:154678005|MESH:D003930|SNOMEDCT_US_2016_03_01:193353002|SNOMEDCT_US_2016_03_01:155107006|UMLS_CUI:C0011884|SNOMEDCT_US_2016_03_01:163997001|SNOMEDCT_US_2016_03_01:309595004|SNOMEDCT_US_2016_03_01:267471001|SNOMEDCT_US_2016_03_01:4855003,Retinal abnormality - diabetes-related,,disease_ontology,,DOID:8947,,,,,,,,,,,,,,,,,,,diabetic retinopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_16335,"[""Adenosine""]","
InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
|
1-(6-Amino-9H-purin-9-yl)-1-deoxy-beta-delta-Ribofuranose
|Boniton|Desoxyadenosine|9-beta-D-Ribofuranosyl-9H-purin-6-amine|
(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
|9beta-delta-Ribofuranosyladenine|6-Amino-9beta-D-ribofuranosyl-9H-purine|9-beta-D-Ribofuranosyladenine|6-Amino-9-beta-D-ribofuranosyl-9H-purine|Adenine riboside|Adenine nucleoside|
(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
|9-beta-D-Ribofuranosidoadenine|9beta-delta-ribofuranosyl-9H-Purin-6-amine|Adenine-9beta-D-Ribofuranoside|Adenocard|9beta-D-Ribofuranosyladenine|Nucleocardyl|Ade-Rib|beta-D-Adenosine|6-Amino-9beta-delta-ribofuranosyl-9H-purine|9-beta-D-Arabinofuranosyladenine|9-beta-delta-Ribofuranosyladenine|9-beta-delta-Arabinofuranosyladenine|Adenocor|9beta-D-ribofuranosyl-9H-Purin-6-amine|9-beta-delta-Ribofuranosyl-9H-purin-6-amine|Ado|Adenyldeoxyriboside|Sandesin|Myocol|C10H13N5O4|OIRDTQYFTABQOQ-KQYNXXCUSA-N|
(2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
|beta-Adenosine|Adenoscan|Deoxyadenosine|Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O|Adenosin|b-D-Adenosine|9-beta-delta-Ribofuranosidoadenine|9-beta-D-ribofuranosyl-9H-purin-6-amine|
(2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
|Adenine Deoxyribonucleoside|Adenine-9beta-delta-Ribofuranoside|beta-delta-Adenosine|
1-(6-Amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose
|
(2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-methylol-tetrahydrofuran-3,4-diol
","
A ribonucleoside composed of a molecule of adenine attached to a ribofuranose moiety via a beta-N(9)-glycosidic bond.
",false,,,http://purl.obolibrary.org/obo/CHEBI_33838,,,,,,,CiteXplore:18000974|CiteXplore:9869364|CiteXplore:21330412|CiteXplore:16181820|CiteXplore:15116424|MetaCyc:ADENOSINE|CiteXplore:15028034|CiteXplore:16917093|Beilstein:93029|CiteXplore:7686877|CiteXplore:16177794|Wikipedia:Adenosine|CiteXplore:6656991|NIST Chemistry WebBook:58-61-7|CiteXplore:16177183|ECMDB:ECMDB00050|CiteXplore:15882454|CiteXplore:12927681|KEGG COMPOUND:C00212|CiteXplore:15455468|ChemIDplus:58-61-7|Gmelin:53385|KNApSAcK:C00007444|PDBeChem:ADN|KEGG COMPOUND:58-61-7|CiteXplore:16181825|CiteXplore:23857558|HMDB:HMDB00050|CiteXplore:16178799|YMDB:YMDB00058|CiteXplore:323854|CiteXplore:11820865|DrugBank:DB00640|KEGG DRUG:D00045|Reaxys:93029|CiteXplore:7056808|CiteXplore:11213237|CiteXplore:16183671|CiteXplore:21848266|CiteXplore:19309105|CiteXplore:17190852|CiteXplore:11978011,"
A ribonucleoside composed of a molecule of adenine attached to a ribofuranose moiety via a beta-N(9)-glycosidic bond.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:40558|CHEBI:40906|CHEBI:2472|CHEBI:13734|CHEBI:40825|CHEBI:22237,,Adenosine|adenosine|ADENOSINE,,chebi_ontology,"
InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
|
1-(6-Amino-9H-purin-9-yl)-1-deoxy-beta-delta-Ribofuranose
|Boniton|Desoxyadenosine|9-beta-D-Ribofuranosyl-9H-purin-6-amine|
(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
|9beta-delta-Ribofuranosyladenine|6-Amino-9beta-D-ribofuranosyl-9H-purine|9-beta-D-Ribofuranosyladenine|6-Amino-9-beta-D-ribofuranosyl-9H-purine|Adenine riboside|Adenine nucleoside|
(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
|9-beta-D-Ribofuranosidoadenine|9beta-delta-ribofuranosyl-9H-Purin-6-amine|Adenine-9beta-D-Ribofuranoside|Adenocard|9beta-D-Ribofuranosyladenine|Nucleocardyl|Ade-Rib|beta-D-Adenosine|6-Amino-9beta-delta-ribofuranosyl-9H-purine|9-beta-D-Arabinofuranosyladenine|9-beta-delta-Ribofuranosyladenine|9-beta-delta-Arabinofuranosyladenine|Adenocor|9beta-D-ribofuranosyl-9H-Purin-6-amine|9-beta-delta-Ribofuranosyl-9H-purin-6-amine|Ado|Adenyldeoxyriboside|Sandesin|Myocol|C10H13N5O4|OIRDTQYFTABQOQ-KQYNXXCUSA-N|
(2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
|beta-Adenosine|Adenoscan|Deoxyadenosine|Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O|Adenosin|b-D-Adenosine|9-beta-delta-Ribofuranosidoadenine|9-beta-D-ribofuranosyl-9H-purin-6-amine|
(2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
|Adenine Deoxyribonucleoside|Adenine-9beta-delta-Ribofuranoside|beta-delta-Adenosine|
1-(6-Amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose
|
(2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-methylol-tetrahydrofuran-3,4-diol
",,,CHEBI:16335,,,,,,,,,,,,,,,,,,,,,,,CHEBI:16335,,,,,Adenosine|adenosine,,CHEBI:16335,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_630,"[""genetic disease""]",,A disease that has_material_basis_in genetic variations in the human genome.,false,,,http://purl.obolibrary.org/obo/DOID_4,,,,,,,,A disease that has_material_basis_in genetic variations in the human genome.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:630,,,,SNOMEDCT_US_2016_03_01:32895009|NCI:C3101|MESH:D030342|UMLS_CUI:C0019247|SNOMEDCT_US_2016_03_01:264530000,,,disease_ontology,,DOID:630,,,,,,,,,,,,,,,,,,,genetic disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_635,"[""acquired immunodeficiency syndrome""]",,"A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per µL of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS.",false,,,http://purl.obolibrary.org/obo/DOID_526,,,,,,,,"A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per µL of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:635,,,,SNOMEDCT_US_2016_03_01:186715004|SNOMEDCT_US_2016_03_01:62479008|EFO:0000765|MESH:D000163|ICD10CM:B20|SNOMEDCT_US_2016_03_01:186705005|SNOMEDCT_US_2016_03_01:266201009|NCI:C2851|OMIM:609423|UMLS_CUI:C0001175|SNOMEDCT_US_2016_03_01:234644008,AIDS|acquired Immune deficiency,,disease_ontology,acquired immune deficiency syndrome,DOID:635,http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,acquired immunodeficiency syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_633,"[""myositis""]",,A myopathy characterized by muscle inflammation.,false,,,http://purl.obolibrary.org/obo/DOID_423,,,,,,,,A myopathy characterized by muscle inflammation.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:633,,,,SNOMEDCT_US_2016_03_01:128496001|SNOMEDCT_US_2016_03_01:203110007|ICD10CM:M60|NCI:C27578|MESH:D009220|OMIM:160750|ICD10CM:G72.49|ICD10CM:M60.9|SNOMEDCT_US_2016_03_01:26889001|UMLS_CUI:C0027121|SNOMEDCT_US_2016_03_01:268108002,Inflammatory disorder of muscle (disorder),,disease_ontology,,DOID:633,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,myositis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_631,"[""fibromyalgia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_633,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:631,,,,SNOMEDCT_US_2016_03_01:203082005|MESH:D005356|ICD10CM:M79.1|SNOMEDCT_US_2016_03_01:203138004|SNOMEDCT_US_2016_03_01:203102006|SNOMEDCT_US_2016_03_01:268107007|SNOMEDCT_US_2016_03_01:247365004|SNOMEDCT_US_2016_03_01:13612005|SNOMEDCT_US_2016_03_01:24693007|SNOMEDCT_US_2016_03_01:203111006|ICD10CM:M79.7|SNOMEDCT_US_2016_03_01:203101004|UMLS_CUI:C0016053|SNOMEDCT_US_2016_03_01:56557000|SNOMEDCT_US_2016_03_01:156727006|SNOMEDCT_US_2016_03_01:1304004|NCI:C87497|NCI:C50566,,,disease_ontology,,DOID:631,,,,,,,,,,,,,,,,,,,fibromyalgia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5559,"[""mediastinal cancer""]",,A thoracic cancer that is located_in the mediastinum.,false,,,http://purl.obolibrary.org/obo/DOID_5093,,,,,,,,A thoracic cancer that is located_in the mediastinum.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5559,,,DOID:9914,ICD10CM:C38.3|NCI:C3221|SNOMEDCT_US_2016_03_01:187889002|MESH:D008479|SNOMEDCT_US_2016_03_01:363494000|SNOMEDCT_US_2016_03_01:93891008|NCI:C3549|SNOMEDCT_US_2016_03_01:94147001|SNOMEDCT_US_2016_03_01:190097009|SNOMEDCT_US_2016_03_01:126725000|ICD9CM:164.9|UMLS_CUI:C0153504|UMLS_CUI:C0025063,mediastinal tumor|Tumour of mediastinum|neoplasm of mediastinum (disorder)|mediastinum cancer,,disease_ontology,,DOID:5559,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,mediastinal cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1040,"[""chronic lymphocytic leukemia""]",,A lymphoblastic leukemia characterized by over production of B-cells and their accumulation in bone marrow and blood.,false,,,http://purl.obolibrary.org/obo/DOID_9500|http://purl.obolibrary.org/obo/DOID_1037,,,,,,,,A lymphoblastic leukemia characterized by over production of B-cells and their accumulation in bone marrow and blood.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1040,,,,UMLS_CUI:C0023434|OMIM:612559|ICD9CM:204.1|MESH:D015451|OMIM:612558|OMIM:609630|NCI:C3163|SNOMEDCT_US_2016_03_01:277473004|ORDO:67038|EFO:0000095|ICD10CM:C91.10|SNOMEDCT_US_2016_03_01:154589005|OMIM:109543|SNOMEDCT_US_2016_03_01:51092000|SNOMEDCT_US_2016_03_01:92814006|OMIM:151400|ICD10CM:C91.1|OMIM:612557,B-cell chronic lymphocytic leukemia|lymphoplasmacytic leukemia|CLL|chronic lymphatic leukemia,,disease_ontology,B-cell chronic lymphoid leukemia,DOID:1040,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,chronic lymphocytic leukemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200050,"[""BTK gene""]",,"The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400133,,,,,,,,"The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200050,,,,,,,,,,,,,,,,695,BTK,AGMX1|ATK|BPK,,,,,,,,,,BTK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100213,"[""Casein kinase i isoform gamma-3""]",,"A casein kinase I isoform gamma-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y6M4] |casein kinase i isoform gamma-3 (CSNK1G3)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300170,,,,,,,,"A casein kinase I isoform gamma-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y6M4] |casein kinase i isoform gamma-3 (CSNK1G3)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100213,,,,https://pharos.nih.gov/idg/targets/Q9Y6M4,,,,,,,,,,,,,CSNK1G3,,,Q9Y6M4,,,,,,,,Casein kinase i isoform gamma-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6132,"[""bronchitis""]",,"A bronchial disease that is an inflammation of the bronchial tubes. It is caused by bacteria and viruses. The disease has_symptom cough with mucus, has_symptom shortness of breath, has_symptom low fever and has_symptom chest tightness.",false,,,http://purl.obolibrary.org/obo/DOID_1176,,,,,,,,"A bronchial disease that is an inflammation of the bronchial tubes. It is caused by bacteria and viruses. The disease has_symptom cough with mucus, has_symptom shortness of breath, has_symptom low fever and has_symptom chest tightness.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6132,,,DOID:13729|DOID:5049|DOID:9982|DOID:6130|DOID:6131|DOID:13503|DOID:9983|DOID:13728|DOID:13504|DOID:13707,ICD10CM:J20|SNOMEDCT_US_2016_03_01:10509002|ICD10CM:J42|SNOMEDCT_US_2016_03_01:266354009|SNOMEDCT_US_2016_03_01:155515002|SNOMEDCT_US_2016_03_01:195956002|SNOMEDCT_US_2016_03_01:155572007|ICD10CM:J40|MESH:D029481|UMLS_CUI:C0008677|SNOMEDCT_US_2016_03_01:195936003|SNOMEDCT_US_2016_03_01:155512004|NCI:C26722|SNOMEDCT_US_2016_03_01:32398004|SNOMEDCT_US_2016_03_01:195713004|SNOMEDCT_US_2016_03_01:35301006|ICD9CM:491|CSP:2596-1500|SNOMEDCT_US_2016_03_01:195733000|SNOMEDCT_US_2016_03_01:63480004|MESH:D001991|ICD10CM:J20.9|UMLS_CUI:C0149514|SNOMEDCT_US_2016_03_01:155616009|SNOMEDCT_US_2016_03_01:266380005|UMLS_CUI:C0006277|ICD9CM:491.9|SNOMEDCT_US_2016_03_01:155566007|ICD9CM:466.0|ICD9CM:490|NCI:C26932|NCI:C2911|SNOMEDCT_US_2016_03_01:266395007|SNOMEDCT_US_2016_03_01:195940007,acute Bronchitis|Chest infection|CI - Chest infection|recurrent wheezy bronchitis|chronic bronchitis|chest cold,,disease_ontology,acute bronchitis and bronchiolitis,DOID:6132,,,,,,,,,,,,,,,,,,,bronchitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200406,"[""PHKG1 gene""]",,"This gene is a member of the Ser/Thr protein kinase family and encodes a protein with one protein kinase domain and two calmodulin-binding domains. This protein is the catalytic member of a 16 subunit protein kinase complex which contains equimolar ratios of 4 subunit types. The complex is a crucial glycogenolytic regulatory enzyme. This gene has two pseudogenes at chromosome 7q11.21 and one at chromosome 11p11.12. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400205,,,,,,,,"This gene is a member of the Ser/Thr protein kinase family and encodes a protein with one protein kinase domain and two calmodulin-binding domains. This protein is the catalytic member of a 16 subunit protein kinase complex which contains equimolar ratios of 4 subunit types. The complex is a crucial glycogenolytic regulatory enzyme. This gene has two pseudogenes at chromosome 7q11.21 and one at chromosome 11p11.12. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200406,,,,,,,,,,,,,,,,5260,PHKG1,PHKG,,,,,,,,,,PHKG1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300120,"[""ABC1 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300108,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300120,,,,,,,,,,,,,,,,,,,,,,,,,,,,ABC1 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00000017,"[""peptide GPCR ligand""]",,A GPCR ligand that is classified as peptide in CHEBI.,false,,,http://purl.obolibrary.org/obo/CHEBI_16670|http://www.drugtargetontology.org/dto/DTO_00000001,,,,,,,,A GPCR ligand that is classified as peptide in CHEBI.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00000017,,,,,,,,,,,,,,,,,,,,,,,,,,,Asiyah Yu Lin,peptide GPCR ligand,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000336,"[""THR315 in ABL1(Q252H)-phosphorylated""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000336,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR315 in ABL1(Q252H)-phosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200128,"[""EPHA4 gene""]",,"This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400153,,,,,,,,"This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200128,,,,,,,,,,,,,,,,2043,EPHA4,HEK8|SEK|TYRO1,,,,,,,,,,EPHA4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000567,"[""HeLa cell""]",,"Human cervix carcinoma established from the epitheloid cervix carcinoma of a 31-year-old black woman in 1951. Later diagnosis changed to adenocarcinoma, first aneuploid, continuously cultured human cell line.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0005590,,,,,,,,"Human cervix carcinoma established from the epitheloid cervix carcinoma of a 31-year-old black woman in 1951. Later diagnosis changed to adenocarcinoma, first aneuploid, continuously cultured human cell line.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000567,,,,,,,BrendaTissueOBO,HELA cell,BTO:0000567,,,,,,,,,,,,,,,,,,,HeLa cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200364,"[""IKBKG gene""]",,"This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Aug 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400102,,,,,,,,"This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Aug 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200364,,,,,,,,,,,,,,,,8517,IKBKG,FIP3|NEMO,,,,,,,,,,IKBKG gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000659,"[""juice""]",,The extractable fluid contents of cells or tissues.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The extractable fluid contents of cells or tissues.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000659,,,,,,,BrendaTissueOBO,,BTO:0000659,,,,,,,,,,,,,,,,,,,juice,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000216,"[""KIT(D816H) kinase domain""]",,V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; C-Kit; KIT; PBT; SCFR,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; C-Kit; KIT; PBT; SCFR,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000216,,,,,,,,,,,,,,,,,,,200216,,,,,,,,,KIT(D816H) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200029,"[""ADRA1D gene""]",,"An alpha-1D adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25100] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400093,,,,,,,,"An alpha-1D adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25100] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200029,,,,,,,,,,,,,,,,146,ADRA1D,ADRA1A,,,,,,,,,,ADRA1D gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002292,"[""flagellum""]",,"Long, slender, threadlike, whiplike extension of certain cells or unicellular organisms used mainly for movements (others for signal transduction). In bacteria, the flagella are helical filaments made up of the protein, flagellin, and rotate like screws. In eukaryotes, such as in cells of animals, plants and protists, they are made up of microtubules surrounded by the plasma membrane and enable the cells to move in a whip-like fashion. Some flagella are not used for movement but in sensation and signal transduction by various cell types, e.g. rod photoreceptor cells of the eye, olfactory receptor neurons of the nose, kinocilium in cochlea of the ear.",false,,,http://purl.obolibrary.org/obo/BTO_0000464|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Long, slender, threadlike, whiplike extension of certain cells or unicellular organisms used mainly for movements (others for signal transduction). In bacteria, the flagella are helical filaments made up of the protein, flagellin, and rotate like screws. In eukaryotes, such as in cells of animals, plants and protists, they are made up of microtubules surrounded by the plasma membrane and enable the cells to move in a whip-like fashion. Some flagella are not used for movement but in sensation and signal transduction by various cell types, e.g. rod photoreceptor cells of the eye, olfactory receptor neurons of the nose, kinocilium in cochlea of the ear.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002292,XPMUser,2013-02-28T07:40:27Z,,,,,BrendaTissueOBO,,BTO:0002292,,,,,,,,,,,,,,,,,,,flagellum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100343,"[""Polycystic kidney disease protein 1-like 1""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100343,,,,https://pharos.nih.gov/idg/targets/Q8TDX9,,,,,,,,,,,,,PKD1L1,,,Q8TDX9,,,,,,,,Polycystic kidney disease protein 1-like 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200118,"[""CCKBR gene""]",,"A cholecystokinin receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32239] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400030,,,,,,,,"A cholecystokinin receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32239] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200118,,,,,,,,,,,,,,,,887,CCKBR,CCKRB,,,,,,,,,,CCKBR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002328,"[""ventral nerve cord""]",,The pair of closely united ventral longitudinal nerves with their segmental ganglia that is characteristic of many elongate invertebrates (as earthworms).,false,,,http://purl.obolibrary.org/obo/BTO_0001656|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The pair of closely united ventral longitudinal nerves with their segmental ganglia that is characteristic of many elongate invertebrates (as earthworms).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002328,,,,,,,BrendaTissueOBO,ventral cord,BTO:0002328,,,,,,,,,,,,,,,,,,,ventral nerve cord,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100440,"[""Olfactory receptor 56a4""]",,"An olfactory receptor 56A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 56A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100440,,,,https://pharos.nih.gov/idg/targets/Q8NGH8,,,,,,,,,,,,,OR56A4,,,Q8NGH8,,,,,,,,Olfactory receptor 56a4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400469,"[""Nav1.4/SCN4A subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400369,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400469,,,,,,,,,,,,,,,,,,,,,,,,,,,,Nav1.4/SCN4A subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200360,"[""OR2A25 gene""]",,"An olfactory receptor 2A25 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A4D2G3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2A25 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A4D2G3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200360,,,,,,,,,,,,,,,,392138,OR2A25,OR2A25P|OR2A27,,,,,,,,,,OR2A25 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200779,"[""TAS2R16 gene""]",,"A taste receptor type 2 member 16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYV7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400014,,,,,,,,"A taste receptor type 2 member 16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYV7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200779,,,,,,,,,,,,,,,,50833,TAS2R16,,,,,,,,,,,TAS2R16 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400372,"[""Transmembrane channel (TMC) family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400372,,,,,,,,,,,,,,,,,,,,,,,,,,,,Transmembrane channel (TMC) family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001377,"[""thymus lymphoma cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0000104|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001377,,,,,,,BrendaTissueOBO,thymic lymphoma cell line,BTO:0001377,,,,,,,,,,,,,,,,,,,thymus lymphoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3181,"[""oligodendroglioma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3070,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3181,,,DOID:3182,UMLS_CUI:C0028945|NCI:C6960|MESH:D009837|UMLS_CUI:C1335110,oligodendroglial neoplasm|oligodendroglial tumor,,disease_ontology,,DOID:3181,,,,,,,,,,,,,,,,,,,oligodendroglioma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300443,"[""C (Shaw) subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300443,,,,,,,,,,,,,,,,,,,,,,,,,,,,C (Shaw) subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002965,"[""M10 melanoma cell""]",,Human melanoma cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0000849|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human melanoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002965,,,,,,,BrendaTissueOBO,M10 cell,BTO:0002965,,,,,,,,,,,,,,,,,,,M10 melanoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100821,"[""Vomeronasal type-1 receptor 2""]",,"A vomeronasal type-1 receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFZ6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300016,,,,,,,,"A vomeronasal type-1 receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFZ6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100821,,,,https://pharos.nih.gov/idg/targets/Q8NFZ6,,,,,,,,,,,,,VN1R2,V1RL2,,Q8NFZ6,,,,,,,,Vomeronasal type-1 receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10780,"[""primary polycythemia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_8432,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10780,,,,OMIM:PS133100|NCI:C26955|UMLS_CUI:C0152264|ICD9CM:289.6|SNOMEDCT_US_2016_03_01:154840005|ICD10CM:D75.0|SNOMEDCT_US_2016_03_01:267571003|MESH:C536842|SNOMEDCT_US_2016_03_01:17342003,familial erythrocytosis|Familiar Polycythemia,,disease_ontology,,DOID:10780,,,,,,,,,,,,,,,,,,,primary polycythemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10782,"[""mesenteric lymphadenitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1602,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10782,,,,SNOMEDCT_US_2016_03_01:191376006|NCI:C26830|ICD9CM:289.2|SNOMEDCT_US_2016_03_01:44897000|MESH:D008640|UMLS_CUI:C0025469|ICD10CM:I88.0|SNOMEDCT_US_2016_03_01:154837005|SNOMEDCT_US_2016_03_01:267548000|SNOMEDCT_US_2016_03_01:191378007,Mesenteric adenitis|Mesenteric lymphadenitis (disorder)|Mesenteric lymphadenitis,,disease_ontology,,DOID:10782,,,,,,,,,,,,,,,,,,,mesenteric lymphadenitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5718,"[""adrenal neuroblastoma""]",,An adrenal gland cancer that derives_from immature neuroblastic cells.,false,,,http://purl.obolibrary.org/obo/DOID_769|http://purl.obolibrary.org/obo/DOID_3953,,,,,,,,An adrenal gland cancer that derives_from immature neuroblastic cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5718,,,,NCI:C4827|SNOMEDCT_US_2016_03_01:281562007|UMLS_CUI:C0559460,neuroblastoma of Adrenal gland,,disease_ontology,,DOID:5718,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,adrenal neuroblastoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2477,"[""motor peripheral neuropathy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_870,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2477,,,,NCI:C75467|SNOMEDCT_US_2016_03_01:398100001|MESH:D015417|ICD10CM:G60.0|SNOMEDCT_US_2016_03_01:128202008|SNOMEDCT_US_2016_03_01:155081008|SNOMEDCT_US_2016_03_01:193158000|UMLS_CUI:C0027888|SNOMEDCT_US_2016_03_01:193160003|SNOMEDCT_US_2016_03_01:193161004,HSMN - Hereditary sensory and motor neuropathy|neuropathic muscular atrophy|HSMN|Hereditary motor and sensory neuropathy,,disease_ontology,,DOID:2477,,,,,,,,,,,,,,,,,,,motor peripheral neuropathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100553,"[""Tyrosine-protein kinase receptor ufo""]",,"A tyrosine-protein kinase receptor UFO that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30530] |tyrosine-protein kinase receptor ufo (AXL)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300189,,,,,,,,"A tyrosine-protein kinase receptor UFO that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30530] |tyrosine-protein kinase receptor ufo (AXL)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100553,,,,https://pharos.nih.gov/idg/targets/P30530,,,,,,,,,,,,,AXL,UFO,,P30530,,,,,,,,Tyrosine-protein kinase receptor ufo,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100684,"[""Olfactory receptor 7G3""]",,"An olfactory receptor 7G3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG95] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 7G3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG95] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100684,,,,https://pharos.nih.gov/idg/targets/Q8NG95,,,,,,,,,,,,,OR7G3,,,Q8NG95,,,,,,,,Olfactory receptor 7G3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5386,"[""lung adenoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3683|http://purl.obolibrary.org/obo/DOID_657,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5386,,,,NCI:C4455|UMLS_CUI:C0345964|SNOMEDCT_US_2016_03_01:254642004,adenoma of lung|pulmonary adenoma,,disease_ontology,,DOID:5386,,,,,,,,,,,,,,,,,,,lung adenoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100291,"[""Mitogen-activated protein kinase kinase kinase 9""]",,"mitogen-activated protein kinase kinase kinase 9 (MLK1)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase kinase kinase 9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P80192] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300284,,,,,,,,"mitogen-activated protein kinase kinase kinase 9 (MLK1)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase kinase kinase 9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P80192] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100291,,,,https://pharos.nih.gov/idg/targets/P80192,,,,,,,,,,,,,MAP3K9,MLK1|PRKE1,,P80192,,,,,,,,Mitogen-activated protein kinase kinase kinase 9,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1962,"[""fallopian tube disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_229,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1962,,,,SNOMEDCT_US_2016_03_01:128134005|MESH:D005184|NCI:C26771|UMLS_CUI:C0015556,,,disease_ontology,,DOID:1962,,,,,,,,,,,,,,,,,,,fallopian tube disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3178,"[""skin papilloma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2615|http://purl.obolibrary.org/obo/DOID_3165,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3178,,,,UMLS_CUI:C0347390|SNOMEDCT_US_2016_03_01:269639005|SNOMEDCT_US_2016_03_01:255184001|NCI:C4614|SNOMEDCT_US_2016_03_01:154613008|SNOMEDCT_US_2016_03_01:189051001,papilloma of skin (disorder)|skin papilloma NOS|Cutaneous papilloma|papilloma of skin|cutaneous papilloma,,disease_ontology,,DOID:3178,,,,,,,,,,,,,,,,,,,skin papilloma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000101,"[""astrocytoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000690,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000101,,,,,,,BrendaTissueOBO,,BTO:0000101,,,,,,,,,,,,,,,,,,,astrocytoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100024,"[""Alpha-protein kinase 2""]",,"An alpha-protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86TB3] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300123,,,,,,,,"An alpha-protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86TB3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100024,,,,https://pharos.nih.gov/idg/targets/Q86TB3,,,,,,,,,,,,,ALPK2,HAK,,Q86TB3,,,,,,,,Alpha-protein kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200326,"[""OR10X1 gene""]",,"An olfactory receptor 10X1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10X1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200326,,,,,,,,,,,,,,,,128367,OR10X1,OR10X1P,,,,,,,,,,OR10X1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005518,"[""PC-9 cell""]",,A cell line derived from human lung adenocarcinoma.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001911,,,,,,,,A cell line derived from human lung adenocarcinoma.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005518,Marion,2013-10-16T14:34:08Z,,,,,BrendaTissueOBO,PC9 cell,BTO:0005518,,,,,,,,,,,,,,,,,,,PC-9 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400288,"[""MSN subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400187,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400288,,,,,,,,,,,,,,,,,,,,,,,,,,,,MSN subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200165,"[""ITPR1 gene""]",,"This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400354,,,,,,,,"This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200165,,,,,,,,,,,,,,,,3708,ITPR1,INSP3R1,,,,,,,,,,ITPR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00500649,"[""Temperature-gated""]",,"""Temperature-gated"" is used in context to certain ion channel proteins. These ion channels open with either an increase in temperature or decrease in temperature.",false,,,http://www.drugtargetontology.org/dto/DTO_00500669,,,,,,,,"""Temperature-gated"" is used in context to certain ion channel proteins. These ion channels open with either an increase in temperature or decrease in temperature.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00500649,,,,,,,,,,,,,,,,,,,,,,,,,,,https://courses.washington.edu/conj/membrane/transport.htm,Temperature-gated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100213,"[""Potassium channel subfamily K member 1""]",,"A potassium channel subfamily K member 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00180] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300359,,,,,,,,"A potassium channel subfamily K member 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00180] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100213,,,,https://pharos.nih.gov/idg/targets/O00180,,,,,,,,,,,,,KCNK1,HOHO1|KCNO1|TWIK1,,O00180,,,,,,,,Potassium channel subfamily K member 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300265,"[""GEK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300145,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300265,,,,,,,,,,,,,,,,,,,,,,,,,,,,GEK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001868,"[""occipital pole""]",,The most posterior promontory of each cerebral hemisphere; the apex of the occipital lobe.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The most posterior promontory of each cerebral hemisphere; the apex of the occipital lobe.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001868,,,,,,,BrendaTissueOBO,polus occipitalis cerebri,BTO:0001868,,,,,,,,,,,,,,,,,,,occipital pole,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300532,"[""Kv1.1/KCNA1 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300436,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300532,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv1.1/KCNA1 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200047,"[""CACNA1S gene""]",,"This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400390,,,,,,,,"This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200047,,,,,,,,,,,,,,,,779,CACNA1S,CACH1|CACN1|CACNL1A3,,,,,,,,,,CACNA1S gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200623,"[""PSTK gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200623,,,,,,,,,,,,,,,,,,,,,,,,,,,,PSTK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100634,"[""Olfactory receptor 5l1""]",,"An olfactory receptor 5L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100634,,,,https://pharos.nih.gov/idg/targets/Q8NGL2,,,,,,,,,,,,,OR5L1,,,Q8NGL2,,,,,,,,Olfactory receptor 5l1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100278,"[""Mitogen-activated protein kinase kinase kinase 12""]",,"mitogen-activated protein kinase kinase kinase 12 (M3K12)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase kinase kinase 12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q12852] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300165,,,,,,,,"mitogen-activated protein kinase kinase kinase 12 (M3K12)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase kinase kinase 12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q12852] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100278,,,,https://pharos.nih.gov/idg/targets/Q12852,,,,,,,,,,,,,MAP3K12,ZPK,,Q12852,,,,,,,,Mitogen-activated protein kinase kinase kinase 12,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000211,"[""KCC4 kinase domain""]",,Calcium/calmodulin-dependent protein kinase type IV; CAMK4; CaMK-GR; MGC36771,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Calcium/calmodulin-dependent protein kinase type IV; CAMK4; CaMK-GR; MGC36771,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000211,,,,,,,,,,,,,,,,,,,200067,,,,,,,,,KCC4 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200475,"[""SIK1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400314,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200475,,,,,,,,,,,,,,,,102724428|150094,SIK1,SIK|SNF1LK,,,,,,,,,,SIK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200176,"[""KCNMB1 gene""]",,"MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400438,,,,,,,,"MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200176,,,,,,,,,,,,,,,,3779,KCNMB1,,,,,,,,,,,KCNMB1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100280,"[""Polycystin-2""]",,"A polycystin-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13563] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300367,,,,,,,,"A polycystin-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13563] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100280,,,,https://pharos.nih.gov/idg/targets/Q13563,,,,,,,,,,,,,PKD2,,,Q13563,,,,,,,,Polycystin-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4483,"[""rhinitis""]",,"A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. The inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip.",false,,,http://purl.obolibrary.org/obo/DOID_2163,,,,,,,,"A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. The inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4483,,,,UMLS_CUI:C0035455|NCI:C34986|SNOMEDCT_US_2016_03_01:70076002|MESH:D012220,,,disease_ontology,runny nose,DOID:4483,,,,,,,,,,,,,,,,,,,rhinitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100803,"[""Putative trace amine-associated receptor 3""]",,"A trace amine-associated receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9P1P4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A trace amine-associated receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9P1P4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100803,,,,https://pharos.nih.gov/idg/targets/Q9P1P4,,,,,,,,,,,,,TAAR3,GPR57,,Q9P1P4,,,,,,,,Putative trace amine-associated receptor 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100041,"[""Adhesion G protein-coupled receptor B3""]",,"A brain-specific angiogenesis inhibitor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60242] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,"A brain-specific angiogenesis inhibitor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60242] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100041,,,,https://pharos.nih.gov/idg/targets/O60242,,,,,,,,,,,,,BAI3,ADGRB3|KIAA0550,,O60242,,,,,,,,Adhesion G protein-coupled receptor B3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003191,"[""SNU-387 cell""]",,Human hepatocellular carcinoma cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0000578|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human hepatocellular carcinoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003191,,,,,,,BrendaTissueOBO,SNU387 cell,BTO:0003191,,,,,,,,,,,,,,,,,,,SNU-387 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1205,"[""allergic hypersensitivity disease""]",,"An immune system disease that is an exaggerated immune response to allergens, such as insect venom, dust mites, pollen, pet dander, drugs or some foods.",false,,,http://purl.obolibrary.org/obo/DOID_0060056,,,,,,,,"An immune system disease that is an exaggerated immune response to allergens, such as insect venom, dust mites, pollen, pet dander, drugs or some foods.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1205,,,,SNOMEDCT_US_2016_03_01:418634005|SNOMEDCT_US_2016_03_01:91232002|SNOMEDCT_US_2016_03_01:257550005|SNOMEDCT_US_2016_03_01:269432007|ICD10CM:T78.40|NCI:C3114|SNOMEDCT_US_2016_03_01:127072000|SNOMEDCT_US_2016_03_01:418168000|SNOMEDCT_US_2016_03_01:21957007|SNOMEDCT_US_2016_03_01:269284003|SNOMEDCT_US_2016_03_01:157758001|SNOMEDCT_US_2016_03_01:282092005|SNOMEDCT_US_2016_03_01:274211000|SNOMEDCT_US_2016_03_01:212998004|SNOMEDCT_US_2016_03_01:106190000|MESH:D006967|SNOMEDCT_US_2016_03_01:212999007|SNOMEDCT_US_2016_03_01:157754004|SNOMEDCT_US_2016_03_01:418925002|SNOMEDCT_US_2016_03_01:421961002|UMLS_CUI:C0020517|SNOMEDCT_US_2016_03_01:421668005,allergic disease|hypersensitivity reaction type I disease|allergy|hypersensitivity,,disease_ontology,,DOID:1205,,,,,,,,,,,,,,,,,,,allergic hypersensitivity disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12053,"[""cryptococcosis""]",,An opportunistic mycosis that results_in fungal infection and has_material_basis_in Cryptococcus neoformans or Cryptococcus gattii.,false,,,http://purl.obolibrary.org/obo/DOID_2473,,,,,,,,An opportunistic mycosis that results_in fungal infection and has_material_basis_in Cryptococcus neoformans or Cryptococcus gattii.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12053,,,,ICD10CM:B45.9|ICD10CM:B45|NCI:C2967|ICD9CM:117.5|SNOMEDCT_US_2016_03_01:187494009|SNOMEDCT_US_2016_03_01:20850004|SNOMEDCT_US_2016_03_01:187097008|UMLS_CUI:C0010414|SNOMEDCT_US_2016_03_01:187090005|MESH:D003453|SNOMEDCT_US_2016_03_01:42386007,torulosis|European cryptococcosis|cryptococcal infection|torula|Busse-Buschke's disease,,disease_ontology,cryptococcus neoformans infection,DOID:12053,,,,,,,,,,,,,,,,,,,cryptococcosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000248,"[""PHE210 in CDK14""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000248,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE210 in CDK14,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4890,"[""juvenile myoclonic epilepsy""]",,"A adolescence-adult electroclinical syndrome that is characterized by brief, involuntary twitching of a muscle or a group of muscles (myoclonus) early in the morning with onset between 12 and 18 years.",false,,,http://purl.obolibrary.org/obo/DOID_0050705,,,,,,,,"A adolescence-adult electroclinical syndrome that is characterized by brief, involuntary twitching of a muscle or a group of muscles (myoclonus) early in the morning with onset between 12 and 18 years.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4890,,,DOID:0050326,OMIM:611364|SNOMEDCT_US_2016_03_01:6204001|NCI:C84796|ORDO:862|UMLS_CUI:C0270853|OMIM:614280|OMIM:608816|OMIM:607631|OMIM:254770|MESH:D020190,,Janz syndrome,disease_ontology,,DOID:4890,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,juvenile myoclonic epilepsy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002922,"[""bronchial epithelial cell""]",,A normal cell of the bronchial epithelium.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A normal cell of the bronchial epithelium.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002922,,,,,,,BrendaTissueOBO,,BTO:0002922,,,,,,,,,,,,,,,,,,,bronchial epithelial cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200602,"[""AK4 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200602,,,,,,,,,,,,,,,,,,,,,,,,,,,,AK4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001534,"[""SW-948 cell""]",,"Human colon adenocarcinoma, established from the colon tumor of a 81-year-old Caucasian woman with colon adenocarcinoma.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001913,,,,,,,,"Human colon adenocarcinoma, established from the colon tumor of a 81-year-old Caucasian woman with colon adenocarcinoma.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001534,,,,,,,BrendaTissueOBO,SW948 cell,BTO:0001534,,,,,,,,,,,,,,,,,,,SW-948 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400416,"[""GRIK1 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400416,,,,,,,,,,,,,,,,,,,,,,,,,,,,GRIK1 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300334,"[""Calcium channel auxiliary subunit types 1-4 (cca-) family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300334,,,,,,,,,,,,,,,,,,,,,,,,,,,,Calcium channel auxiliary subunit types 1-4 (cca-) family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2679,"[""dysembryoplastic neuroepithelial tumor""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060090,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2679,,,,UMLS_CUI:C1266177|SNOMEDCT_US_2016_03_01:128788005|NCI:C9505|SNOMEDCT_US_2016_03_01:87211000119104,Dysembryoplastic neuroepithelial tumor (morphologic abnormality)|Dysembryoplastic Neuroepithelial neoplasm,,disease_ontology,,DOID:2679,,,,,,,,,,,,,,,,,,,dysembryoplastic neuroepithelial tumor,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000149,"[""ERK3 kinase domain""]",,Mitogen-activated protein kinase 6; DKFZp686F03189; ERK3; HsT17250; MAPK6; p97MAPK; PRKM6,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase 6; DKFZp686F03189; ERK3; HsT17250; MAPK6; p97MAPK; PRKM6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000149,,,,,,,,,,,,,,,,,,,200153,,,,,,,,,ERK3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001598,"[""splenocyte""]",,A macrophage of the spleen.,false,,,http://purl.obolibrary.org/obo/BTO_0000801|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A macrophage of the spleen.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001598,,,,,,,BrendaTissueOBO,,BTO:0001598,,,,,,,,,,,,,,,,,,,splenocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200815,"[""AVPR1A gene""]",,"A vasopressin V1a receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P37288] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A vasopressin V1a receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P37288] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200815,,,,,,,,,,,,,,,,552,AVPR1A,AVPR1,,,,,,,,,,AVPR1A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100139,"[""Glutamate receptor ionotropic, kainate 1""]",,"A glutamate receptor ionotropic, kainate 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P39086] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300416,,,,,,,,"A glutamate receptor ionotropic, kainate 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P39086] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100139,,,,https://pharos.nih.gov/idg/targets/P39086,,,,,,,,,,,,,GRIK1,GLUR5,,P39086,,,,,,,,"Glutamate receptor ionotropic, kainate 1",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3855,"[""seminal vesicle tumor""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060087,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3855,,,,UMLS_CUI:C0341767|NCI:C39908|SNOMEDCT_US_2016_03_01:236740006,tumor of seminal vesicle (disorder)|Seminal Vesicle neoplasm,,disease_ontology,,DOID:3855,,,,,,,,,,,,,,,,,,,seminal vesicle tumor,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300018,"[""Adenosine receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300018,,,,,,,,,,,,,,,,,,,,,,,,,,,,Adenosine receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000144,"[""EPHB4 kinase domain""]",,Ephrin type-B receptor 4; EPHB4; HTK; MYK1; TYRO11,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Ephrin type-B receptor 4; EPHB4; HTK; MYK1; TYRO11,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000144,,,,,,,,,,,,,,,,,,,200146,,,,,,,,,EPHB4 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060467,"[""humeroradial synostosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_11971,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060467,elvira,2015-11-11T21:29:39Z,,ICD10CM:Q74.0|UMLS_CUI:C0431800|ORDO:3265|OMIM:143050|OMIM:236400,,,disease_ontology,humero-radial fusion,DOID:0060467,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,humeroradial synostosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060466,"[""gingival fibromatosis""]",,"A gingival overgrowth characterized by benign, slowly progressive, nonhemorrhagic, fibrous enlargement of the oral masticatory mucosa.",false,,,http://purl.obolibrary.org/obo/DOID_3086,,,,,,,,"A gingival overgrowth characterized by benign, slowly progressive, nonhemorrhagic, fibrous enlargement of the oral masticatory mucosa.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060466,elvira,2015-11-04T16:47:21Z,,OMIM:605544|OMIM:611010|OMIM:609955|MESH:C562884|UMLS_CUI:C0399440|OMIM:135300|ORDO:2024|SNOMEDCT_US_2016_03_01:109620006,hereditary gingival fibromatosis|hereditary gingival hyperplasia,,disease_ontology,,DOID:0060466,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,gingival fibromatosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000078,"[""CDK4-cyclinD3 kinase domain""]",,Cyclin-dependent kinase 4; cell division protein kinase 4,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Cyclin-dependent kinase 4; cell division protein kinase 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000078,,,,,,,,,,,,,,,,,,,200078,,,,,,,,,CDK4-cyclinD3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1724,"[""duodenal ulcer""]",,Adding UMLS CUI for Curling Ulcer C0013295.,false,,,http://purl.obolibrary.org/obo/DOID_750,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1724,,,DOID:9782|DOID:9781|DOID:1723|DOID:12880|DOID:10297|DOID:11480|DOID:9780|DOID:13836|DOID:9783,SNOMEDCT_US_2016_03_01:155700000|SNOMEDCT_US_2016_03_01:196669008|SNOMEDCT_US_2016_03_01:155691003|SNOMEDCT_US_2016_03_01:39755000|SNOMEDCT_US_2016_03_01:196679005|MESH:D004381|SNOMEDCT_US_2016_03_01:51868009|SNOMEDCT_US_2016_03_01:196672001|UMLS_CUI:C0010474|SNOMEDCT_US_2016_03_01:553009|SNOMEDCT_US_2016_03_01:196651004|ICD9CM:532|SNOMEDCT_US_2016_03_01:367474008|SNOMEDCT_US_2016_03_01:235703009|SNOMEDCT_US_2016_03_01:196680008|ICD10CM:K26|UMLS_CUI:C0013295|NCI:C26755,Curling's ulcers|Stress Ulcer|Curling Ulcer,,disease_ontology,,DOID:1724,,,,,,,,,,,,,,,,,Adding UMLS CUI for Curling Ulcer C0013295.,,duodenal ulcer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100271,"[""Substance-k receptor""]",,"A substance-K receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21452] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300066,,,,,,,,"A substance-K receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21452] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100271,,,,https://pharos.nih.gov/idg/targets/P21452,,,,,,,,,,,,,TACR2,NK2R|NKNAR|TAC2R,,P21452,,,,,,,,Substance-k receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000463,"[""YANK2 kinase domain""]",,Serine/threonine kinase 32B; HSA250839; STK32; STK32B; STKG6; YANK2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine kinase 32B; HSA250839; STK32; STK32B; STKG6; YANK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000463,,,,,,,,,,,,,,,,,,,200463,,,,,,,,,YANK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100149,"[""Fibroblast growth factor receptor 1""]",,"A basic fibroblast growth factor receptor 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P11362] |fibroblast growth factor receptor 1 (FGFR1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300158,,,,,,,,"A basic fibroblast growth factor receptor 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P11362] |fibroblast growth factor receptor 1 (FGFR1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100149,,,,https://pharos.nih.gov/idg/targets/P11362,,,,,,,,,,,,,FGFR1,BFGFR|CEK|FGFBR|FLG|FLT2|HBGFR,,P11362,,,,,,,,Fibroblast growth factor receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100369,"[""Nik-related protein kinase""]",,"A Nik-related protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z2Y5] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300187,,,,,,,,"A Nik-related protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z2Y5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100369,,,,https://pharos.nih.gov/idg/targets/Q7Z2Y5,,,,,,,,,,,,,NRK,,,Q7Z2Y5,,,,,,,,Nik-related protein kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001629,"[""left ventricle""]",,The ventricles are the two lower chambers of the heart. The left ventricle is the chamber that receives blood from the left atrium and pumps it out under high pressure to the body via the aorta.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The ventricles are the two lower chambers of the heart. The left ventricle is the chamber that receives blood from the left atrium and pumps it out under high pressure to the body via the aorta.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001629,,,,,,,BrendaTissueOBO,,BTO:0001629,,,,,,,,,,,,,,,,,,,left ventricle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200552,"[""UCK2 gene""]",,"This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.[provided by RefSeq, Oct 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03491024,,,,,,,,"This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.[provided by RefSeq, Oct 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200552,,,,,,,,,,,,,,,,7371,UCK2,UMPK,,,,,,,,,,UCK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100314,"[""Misshapen-like kinase 1""]",,"misshapen-like kinase 1 (MINK)  with  no mutation  in a nonphosphorylated state|A misshapen-like kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N4C8] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300288,,,,,,,,"misshapen-like kinase 1 (MINK)  with  no mutation  in a nonphosphorylated state|A misshapen-like kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N4C8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100314,,,,https://pharos.nih.gov/idg/targets/Q8N4C8,,,,,,,,,,,,,MINK1,B55|MAP4K6|MINK|YSK2|ZC3,,Q8N4C8,,,,,,,,Misshapen-like kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000551,"[""lung cancer cell""]",,Cancer cell of the major organ of respiration the lung.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Cancer cell of the major organ of respiration the lung.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000551,,,,,,,BrendaTissueOBO,lung carcinoma cell,BTO:0000551,,,,,,,,,,,,,,,,,,,lung cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100093,"[""Prosaposin receptor GPR37L1""]",,"A prosaposin receptor GPR37L1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O60883] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300038,,,,,,,,"A prosaposin receptor GPR37L1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O60883] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100093,,,,https://pharos.nih.gov/idg/targets/O60883,,,,,,,,,,,,,GPR37L1,ETBRLP2,,O60883,,,,,,,,Prosaposin receptor GPR37L1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005725,"[""HuH-7-Lunet cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005725,Marion,2015-04-20T09:57:36Z,,,,,BrendaTissueOBO,Huh7-Lunet cell|Lunet cell,BTO:0005725,,,,,,,,,,,,,,,,,,,HuH-7-Lunet cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003595,"[""knee""]",,"1: A joint in the middle part of the human leg that is the articulation between the femur, tibia, and patella; also: the part of the leg that includes this joint. 2a: The joint in the hind leg of a four-footed vertebrate that corresponds to the human knee. 2b: The carpal joint of the foreleg of a four-footed vertebrate. 2c: The tarsal joint of a bird. 2d: The joint between the femur and tibia of an insect.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"1: A joint in the middle part of the human leg that is the articulation between the femur, tibia, and patella; also: the part of the leg that includes this joint. 2a: The joint in the hind leg of a four-footed vertebrate that corresponds to the human knee. 2b: The carpal joint of the foreleg of a four-footed vertebrate. 2c: The tarsal joint of a bird. 2d: The joint between the femur and tibia of an insect.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003595,,,,,,,BrendaTissueOBO,,BTO:0003595,,,,,,,,,,,,,,,,,,,knee,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100059,"[""Voltage-dependent calcium channel gamma-5 subunit""]",,"A voltage-dependent calcium channel gamma-5 subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UF02] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300336,,,,,,,,"A voltage-dependent calcium channel gamma-5 subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UF02] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100059,,,,https://pharos.nih.gov/idg/targets/Q9UF02,,,,,,,,,,,,,CACNG5,,,Q9UF02,,,,,,,,Voltage-dependent calcium channel gamma-5 subunit,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200058,"[""CCR6 gene""]",,"A C-C chemokine receptor type 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51684] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400095,,,,,,,,"A C-C chemokine receptor type 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51684] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200058,,,,,,,,,,,,,,,,1235,CCR6,CKRL3|CMKBR6|GPR29|STRL22,,,,,,,,,,CCR6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001498,"[""renal proximal tubule""]",,"The convoluted portion of the vertebrate nephron that lies between Bowman's capsule and the loop of Henle and functions especially in the resorption of sugar, sodium and chloride ions, and water from the glomerular filtrate.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The convoluted portion of the vertebrate nephron that lies between Bowman's capsule and the loop of Henle and functions especially in the resorption of sugar, sodium and chloride ions, and water from the glomerular filtrate.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001498,,,,,,,BrendaTissueOBO,proximal tubule|proximal convoluted tubule,BTO:0001498,,,,,,,,,,,,,,,,,,,renal proximal tubule,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000420,"[""VAL550 in FGFR4""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000420,,,,,,,,,,,,,,,,,,,,,,,,,,,,VAL550 in FGFR4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000236,"[""cerebral white matter""]",,"Whitish nerve tissue, especially of the brain and spinal cord, consisting chiefly of myelinated nerve fibers.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Whitish nerve tissue, especially of the brain and spinal cord, consisting chiefly of myelinated nerve fibers.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000236,,,,,,,BrendaTissueOBO,white matter,BTO:0000236,,,,,,,,,,,,,,,,,,,cerebral white matter,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200274,"[""NMUR1 gene""]",,"A neuromedin-U receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HB89] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400067,,,,,,,,"A neuromedin-U receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HB89] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200274,,,,,,,,,,,,,,,,10316,NMUR1,GPR66,,,,,,,,,,NMUR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300052,"[""Melanin-concentrating hormone receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300052,,,,,,,,,,,,,,,,,,,,,,,,,,,,Melanin-concentrating hormone receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400522,"[""GABRR2 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400522,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRR2 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200316,"[""TMC8 gene""]",,"Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400329,,,,,,,,"Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200316,,,,,,,,,,,,,,,,147138,TMC8,EVER2|EVIN2,,,,,,,,,,TMC8 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100347,"[""Myosin light chain kinase 2, skeletal/cardiac muscle""]",,"myosin light chain kinase 2, skeletal/cardiac muscle (MYLK2)  with  no mutation  in a nonphosphorylated state|A myosin light chain kinase 2, skeletal/cardiac muscle that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H1R3] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300196,,,,,,,,"myosin light chain kinase 2, skeletal/cardiac muscle (MYLK2)  with  no mutation  in a nonphosphorylated state|A myosin light chain kinase 2, skeletal/cardiac muscle that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H1R3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100347,,,,https://pharos.nih.gov/idg/targets/Q9H1R3,,,,,,,,,,,,,MYLK2,,,Q9H1R3,,,,,,,,"Myosin light chain kinase 2, skeletal/cardiac muscle",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002372,"[""neuroepithelioma cell""]",,"A rare type of neuroepithelial tumor, usually found in the brain or retina, composed of primitive neuroepithelial cells lining the tubular spaces.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A rare type of neuroepithelial tumor, usually found in the brain or retina, composed of primitive neuroepithelial cells lining the tubular spaces.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002372,,,,,,,BrendaTissueOBO,neuroepithelial tumor cell|neurocytoma cell,BTO:0002372,,,,,,,,,,,,,,,,,,,neuroepithelioma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050922,"[""gastrointestinal carcinoma""]",,A gastrointestinal system cancer that has_material_basis_in epithelial cells.,false,,,http://purl.obolibrary.org/obo/DOID_3119,,,,,,,,A gastrointestinal system cancer that has_material_basis_in epithelial cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050922,lschriml,2014-10-21T11:56:36Z,,,,,disease_ontology,,DOID:0050922,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,gastrointestinal carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4905,"[""pancreatic carcinoma""]",,A pancreas cancer that derives_from epithelial cells located_in the pancreas.,false,,,http://purl.obolibrary.org/obo/DOID_1793|http://purl.obolibrary.org/obo/DOID_305,,,,,,,,A pancreas cancer that derives_from epithelial cells located_in the pancreas.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4905,,,,EFO:0002618|SNOMEDCT_US_2016_03_01:255089009|SNOMEDCT_US_2016_03_01:372142002|MESH:C562463|OMIM:260350|UMLS_CUI:C0235974|SNOMEDCT_US_2016_03_01:154475002|SNOMEDCT_US_2016_03_01:93938001|NCI:C3850,carcinoma of pancreas (disorder)|carcinoma of pancreas|Exocrine pancreas carcinoma,,disease_ontology,"exocrine cancer|Pancreatic carcinoma, familial",DOID:4905,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,pancreatic carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80266,"[""nociceptin""]","1807.981|L-Phe-Gly-Gly-L-Phe-L-Thr-Gly-L-Ala-L-Arg-L-Lys-L-Ser-L-Ala-L-Arg-L-Lys-L-Leu-L-Ala-L-Asn-L-Gln|C79H129N27O22|Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln|InChI=1S/C79H129N27O22/c1-41(2)33-54(72(122)95-44(5)66(116)103-56(36-59(84)110)73(123)102-53(77(127)128)27-28-58(83)109)104-70(120)49(23-13-15-29-80)100-69(119)52(26-18-32-90-79(87)88)99-65(115)43(4)96-75(125)57(40-107)105-71(121)50(24-14-16-30-81)101-68(118)51(25-17-31-89-78(85)86)98-64(114)42(3)94-61(112)39-93-76(126)63(45(6)108)106-74(124)55(35-47-21-11-8-12-22-47)97-62(113)38-91-60(111)37-92-67(117)48(82)34-46-19-9-7-10-20-46/h7-12,19-22,41-45,48-57,63,107-108H,13-18,23-40,80-82H2,1-6H3,(H2,83,109)(H2,84,110)(H,91,111)(H,92,117)(H,93,126)(H,94,112)(H,95,122)(H,96,125)(H,97,113)(H,98,114)(H,99,115)(H,100,119)(H,101,118)(H,102,123)(H,103,116)(H,104,120)(H,105,121)(H,106,124)(H,127,128)(H4,85,86,89)(H4,87,88,90)/t42-,43-,44-,45+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,63-/m0/s1|PheGlyGlyPheThrGlyAlaArgLysSerAlaArgLysLeuAlaAsnGln|Orphanin FQ|Nociceptin (1-17)|FGGFTGARKSARKLANQ|PULGYDLMFSFVBL-SMFNREODSA-N|C([C@@H](N)CC=1C=CC=CC1)(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(N[C@H](C(=O)N[C@H](C(N[C@H](C(N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CCC(=O)N)CC(=O)N)C)=O)CC(C)C)=O)CCCCN)CCCNC(=N)N)=O)C)CO)CCCCN)CCCNC(=N)N)C)[C@@H](C)O)CC=2C=CC=CC2|1809.040|0","A seventenn-membered polypeptide consisting of Phe, Gly, Gly, Phe, Thr, Gly, Ala, Arg, Lys, Ser, Ala, Arg, Lys, Leu, Ala, Asn and Gln residue joined in sequence.",false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16044|CAS:170713-75-4|Reaxys:24158864|PMID:25677778|Reaxys:9753661|PMID:25724763,"A seventenn-membered polypeptide consisting of Phe, Gly, Gly, Phe, Thr, Gly, Ala, Arg, Lys, Ser, Ala, Arg, Lys, Leu, Ala, Asn and Gln residue joined in sequence.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,L-phenylalanylglycylglycyl-L-phenylalanyl-L-threonylglycyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-alanyl-L-asparaginyl-L-glutamine,,chebi_ontology,"1807.981|L-Phe-Gly-Gly-L-Phe-L-Thr-Gly-L-Ala-L-Arg-L-Lys-L-Ser-L-Ala-L-Arg-L-Lys-L-Leu-L-Ala-L-Asn-L-Gln|C79H129N27O22|Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln|InChI=1S/C79H129N27O22/c1-41(2)33-54(72(122)95-44(5)66(116)103-56(36-59(84)110)73(123)102-53(77(127)128)27-28-58(83)109)104-70(120)49(23-13-15-29-80)100-69(119)52(26-18-32-90-79(87)88)99-65(115)43(4)96-75(125)57(40-107)105-71(121)50(24-14-16-30-81)101-68(118)51(25-17-31-89-78(85)86)98-64(114)42(3)94-61(112)39-93-76(126)63(45(6)108)106-74(124)55(35-47-21-11-8-12-22-47)97-62(113)38-91-60(111)37-92-67(117)48(82)34-46-19-9-7-10-20-46/h7-12,19-22,41-45,48-57,63,107-108H,13-18,23-40,80-82H2,1-6H3,(H2,83,109)(H2,84,110)(H,91,111)(H,92,117)(H,93,126)(H,94,112)(H,95,122)(H,96,125)(H,97,113)(H,98,114)(H,99,115)(H,100,119)(H,101,118)(H,102,123)(H,103,116)(H,104,120)(H,105,121)(H,106,124)(H,127,128)(H4,85,86,89)(H4,87,88,90)/t42-,43-,44-,45+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,63-/m0/s1|PheGlyGlyPheThrGlyAlaArgLysSerAlaArgLysLeuAlaAsnGln|Orphanin FQ|Nociceptin (1-17)|FGGFTGARKSARKLANQ|PULGYDLMFSFVBL-SMFNREODSA-N|C([C@@H](N)CC=1C=CC=CC1)(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(N[C@H](C(=O)N[C@H](C(N[C@H](C(N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CCC(=O)N)CC(=O)N)C)=O)CC(C)C)=O)CCCCN)CCCNC(=N)N)=O)C)CO)CCCCN)CCCNC(=N)N)C)[C@@H](C)O)CC=2C=CC=CC2|1809.040|0",,,CHEBI:80266,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80266,,,,,nociceptin,,CHEBI:80266,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005463,"[""Huh-7.5.1 cell""]",,Huh-7.5.1 cells were derived from the Huh-7.5 GFP-HCV replicon cell line I/5A-GFP-6.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Huh-7.5.1 cells were derived from the Huh-7.5 GFP-HCV replicon cell line I/5A-GFP-6.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005463,XPMUser,2013-09-08T09:56:13Z,,,,,BrendaTissueOBO,,BTO:0005463,,,,,,,,,,,,,,,,,,,Huh-7.5.1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000203,"[""JAK2(Kin.Dom.2) kinase domain""]",,Janus kinase 2; JAK2; JAK2-catalytic; JTK10,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Janus kinase 2; JAK2; JAK2-catalytic; JTK10,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000203,,,,,,,,,,,,,,,,,,,200208,,,,,,,,,JAK2(Kin.Dom.2) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400142,"[""CK2 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400111,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400142,,,,,,,,,,,,,,,,,,,,,,,,,,,,CK2 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200358,"[""OR2A12 gene""]",,"An olfactory receptor 2A12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2A12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200358,,,,,,,,,,,,,,,,346525,OR2A12,OR2A12P,,,,,,,,,,OR2A12 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400526,"[""GLRA2 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400409,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400526,,,,,,,,,,,,,,,,,,,,,,,,,,,,GLRA2 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060242,"[""synpolydactyly""]",,A syndactyly characterized by an increased number of digits; often a result of a mutation in the HOX D13 gene.,false,,,http://purl.obolibrary.org/obo/DOID_11193,,,,,,,,A syndactyly characterized by an increased number of digits; often a result of a mutation in the HOX D13 gene.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060242,emitraka,2015-01-27T16:57:56Z,,OMIM:610234|MESH:C538153|NCI:C75003|UMLS_CUI:C2699746|OMIM:608180|ORDO:295195|OMIM:186000,syndactyly type 2,,disease_ontology,,DOID:0060242,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,NT MGI.,,synpolydactyly,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060249,"[""scoliosis""]",,A bone structure disease characterized by an appreciable lateral deviation in the normally straight vertical line of the spine.,false,,,http://purl.obolibrary.org/obo/DOID_0080010,,,,,,,,A bone structure disease characterized by an appreciable lateral deviation in the normally straight vertical line of the spine.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060249,emitraka,2015-01-29T15:44:16Z,,SNOMEDCT_US_2016_03_01:298382003|SNOMEDCT_US_2016_03_01:36773001|ICD10CM:M41|NCI:C78603|SNOMEDCT:298382003|UMLS_CUI:C0036439|SNOMEDCT:20944008|MESH:D012600|HP:0002650|ICD10CM:M41.9,,,disease_ontology,,DOID:0060249,,,,,,,,,,,,,,,,,NT MGI add.,,scoliosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060243,"[""stuttering""]",,An articulation disorder characterized by involuntary sound repetition and disruption or blocking of speech.,false,,,http://purl.obolibrary.org/obo/DOID_4186,,,,,,,,An articulation disorder characterized by involuntary sound repetition and disruption or blocking of speech.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060243,emitraka,2015-01-28T16:04:54Z,,ICD10CM:F80.81|SNOMEDCT_US_2016_03_01:154935003|UMLS_CUI:C0038131|SNOMEDCT_US_2016_03_01:191987007|NCI:C35043|UMLS_CUI:C0454542|UMLS_CUI:C0038506|SNOMEDCT_US_2016_03_01:39423001|OMIM:184450|SNOMEDCT_US_2016_03_01:29916003|SNOMEDCT_US_2016_03_01:192632007|UMLS_CUI:C0751529|UMLS_CUI:C0751527|SNOMEDCT_US_2016_03_01:231513008|SNOMEDCT_US_2016_03_01:229631007|OMIM:609261|OMIM:614668|UMLS_CUI:C3489627|SNOMEDCT_US_2016_03_01:416163003|UMLS_CUI:C0751528|OMIM:614655|SNOMEDCT_US_2016_03_01:231512003|MESH:D013342,familial persistent stuttering|stammering,,disease_ontology,,DOID:0060243,,,,,,,,,,,,,,,,,NT MGI.,,stuttering,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200808,"[""TPRA1 gene""]",,"A transmembrane protein adipocyte-associated 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86W33] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400090,,,,,,,,"A transmembrane protein adipocyte-associated 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86W33] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200808,,,,,,,,,,,,,,,,131601,TPRA1,GPR175|TMEM227,,,,,,,,,,TPRA1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300169,"[""PKA family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300169,,,,,,,,,,,,,,,,,,,,,,,,,,,,PKA family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001045,"[""T-lymphocyte cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001008,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001045,,,,,,,BrendaTissueOBO,T-cell line,BTO:0001045,,,,,,,,,,,,,,,,,,,T-lymphocyte cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100069,"[""Chloride channel CLIC-like protein 1""]",,"A chloride channel CLIC-like protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96S66] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300340,,,,,,,,"A chloride channel CLIC-like protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96S66] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100069,,,,https://pharos.nih.gov/idg/targets/Q96S66,,,,,,,,,,,,,CLCC1,KIAA0761|MCLC,,Q96S66,,,,,,,,Chloride channel CLIC-like protein 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14679,"[""VACTERL association""]",,"A syndrome that is characterized by the presence of at least three of the following: vertebral defects, anal atresia, cardiac defects, tracheo-esophageal fistula, renal anomalies, and limb abnormalities.",false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,"A syndrome that is characterized by the presence of at least three of the following: vertebral defects, anal atresia, cardiac defects, tracheo-esophageal fistula, renal anomalies, and limb abnormalities.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14679,,,,ICD10CM:Q87.2|SNOMEDCT_US_2016_03_01:205830006|OMIM:192350|MESH:C536534|OMIM:276950|SNOMEDCT_US_2016_03_01:27742002|UMLS_CUI:C0220708,vater ASSOCIATION|vater association (disorder)|vater association [dup] (disorder)|VACTERL/VATER association,,disease_ontology,VATER syndrome,DOID:14679,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,VACTERL association,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400467,"[""Nav1.3/SCN3A subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400369,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400467,,,,,,,,,,,,,,,,,,,,,,,,,,,,Nav1.3/SCN3A subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100689,"[""Olfactory receptor 8B8""]",,"An olfactory receptor 8B8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15620] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 8B8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15620] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100689,,,,https://pharos.nih.gov/idg/targets/Q15620,,,,,,,,,,,,,OR8B8,,,Q15620,,,,,,,,Olfactory receptor 8B8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400001,"[""GPCR gene""]",,G-protein-coupled receptors (GPCRs) are the largest and most diverse group of membrane receptors in eukaryotes.,false,,,http://www.drugtargetontology.org/dto/DTO_00200000,,,,,,,,G-protein-coupled receptors (GPCRs) are the largest and most diverse group of membrane receptors in eukaryotes.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400001,,,,,,,,,,,,,,,,,,,,,,,,,,,https://www.nature.com/scitable/topicpage/gpcr-14047471,GPCR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400251,"[""ATR subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400129,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400251,,,,,,,,,,,,,,,,,,,,,,,,,,,,ATR subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000345,"[""PIK3CA(E545K) kinase domain""]",,"Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000345,,,,,,,,,,,,,,,,,,,200327,,,,,,,,,PIK3CA(E545K) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100435,"[""Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase""]",,"A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99640] |membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300212,,,,,,,,"A membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99640] |membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100435,,,,https://pharos.nih.gov/idg/targets/Q99640,,,,,,,,,,,,,PKMYT1,MYT1,,Q99640,,,,,,,,Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_7147,"[""ankylosing spondylitis""]",,"A bone inflammation disease that results_in inflammation in the joints of the spine and pelvis. The disease has_symptom pain, has_symptom stiffness in the spine, has_symptom stiffness in the neck, has_symptom stiffness in the hips, has_symptom stiffness in the jaw and has_symptom stiffness in the rib cage.",false,,,http://purl.obolibrary.org/obo/DOID_3342,,,,,,,,"A bone inflammation disease that results_in inflammation in the joints of the spine and pelvis. The disease has_symptom pain, has_symptom stiffness in the spine, has_symptom stiffness in the neck, has_symptom stiffness in the hips, has_symptom stiffness in the jaw and has_symptom stiffness in the rib cage.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:7147,,,,SNOMEDCT_US_2016_03_01:156619005|UMLS_CUI:C0038013|ICD9CM:720.0|SNOMEDCT_US_2016_03_01:9631008|ORDO:825|NCI:C84564|ICD10CM:M45|EFO:0003898|MESH:D013167,Bekhterev syndrome|Bekhterev's disease|Marie-Strumpell disease,,disease_ontology,,DOID:7147,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,ankylosing spondylitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100596,"[""Olfactory receptor 4K15""]",,"An olfactory receptor 4K15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH41] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4K15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH41] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100596,,,,https://pharos.nih.gov/idg/targets/Q8NH41,,,,,,,,,,,,,OR4K15,,,Q8NH41,,,,,,,,Olfactory receptor 4K15,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6245,"[""renal oncocytoma""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_3116,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6245,,,,UMLS_CUI:C0346255|MESH:C537750|OMIM:553000|NCI:C4526|SNOMEDCT_US_2016_03_01:254922006,renal epithelial Oncocytic tumor|Oncocytoma of kidney (disorder),,disease_ontology,,DOID:6245,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,renal oncocytoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000106,"[""cranial ganglion""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000497,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000106,,,,,,,BrendaTissueOBO,head ganglion,BTO:0000106,,,,,,,,,,,,,,,,,,,cranial ganglion,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003082,"[""uterine epithelium""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000416,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003082,,,,,,,BrendaTissueOBO,uterus epithelium,BTO:0003082,,,,,,,,,,,,,,,,,,,uterine epithelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000154,"[""MET233 in M3K13""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000154,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET233 in M3K13,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001800,"[""retinal ganglion cell""]",,"Cells of the innermost nuclear layer of the retina, the ganglion cell layer, which project axons through the optic nerve to the brain. They are quite variable in size and in the shapes of their dendritic arbors, which are generally confined to the inner plexiform layer.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Cells of the innermost nuclear layer of the retina, the ganglion cell layer, which project axons through the optic nerve to the brain. They are quite variable in size and in the shapes of their dendritic arbors, which are generally confined to the inner plexiform layer.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001800,,,,,,,BrendaTissueOBO,,BTO:0001800,,,,,,,,,,,,,,,,,,,retinal ganglion cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400244,"[""WNK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400244,,,,,,,,,,,,,,,,,,,,,,,,,,,,WNK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200071,"[""CDK5 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400261,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200071,,,,,,,,,,,,,,,,1020,CDK5,CDKN5,,,,,,,,,,CDK5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100764,"[""Sphingosine 1-phosphate receptor 2""]",,"A sphingosine 1-phosphate receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95136] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A sphingosine 1-phosphate receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95136] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100764,,,,https://pharos.nih.gov/idg/targets/O95136,,,,,,,,,,,,,S1PR2,EDG5,,O95136,,,,,,,,Sphingosine 1-phosphate receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1475,"[""lymphangioma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060084,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1475,,,,ICD9CM:228.1|NCI:C8965|SNOMEDCT_US_2016_03_01:93168006|SNOMEDCT_US_2016_03_01:69044001|SNOMEDCT_US_2016_03_01:154625006|ICD10CM:D18.1|SNOMEDCT_US_2016_03_01:254836000|SNOMEDCT_US_2016_03_01:189875000|MESH:D008202|SNOMEDCT_US_2016_03_01:269646001|SNOMEDCT_US_2016_03_01:253057002|SNOMEDCT_US_2016_03_01:400178008|UMLS_CUI:C0024221|SNOMEDCT_US_2016_03_01:189200000,benign lymphangioma (morphologic abnormality)|Congenital lymphangioma,,disease_ontology,,DOID:1475,,,,,,,,,,,,,,,,,,,lymphangioma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14753,"[""isovaleric acidemia""]",,An organic acidemia that disrupts or prevents normal metabolism of the branched-chain amino acid leucine.,false,,,http://purl.obolibrary.org/obo/DOID_0060159,,,,,,,,An organic acidemia that disrupts or prevents normal metabolism of the branched-chain amino acid leucine.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14753,,,,SNOMEDCT_US_2016_03_01:87827003|UMLS_CUI:C0268575|ICD10CM:E71.110|MESH:C538167|OMIM:243500|NCI:C98964,Isovaleryl-CoA dehydrogenase deficiency (disorder)|isovaleric aciduria|isovaleric acid CoA dehydrogenase deficiency,,disease_ontology,,DOID:14753,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,isovaleric acidemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000202,"[""MET782 in LATS1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000202,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET782 in LATS1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400460,"[""RYR1 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400354,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400460,,,,,,,,,,,,,,,,,,,,,,,,,,,,RYR1 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200022,"[""CHRM2 gene""]",,"A muscarinic acetylcholine receptor M2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08172] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400020,,,,,,,,"A muscarinic acetylcholine receptor M2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08172] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200022,,,,,,,,,,,,,,,,1129,CHRM2,,,,,,,,,,,CHRM2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1442,"[""Alpers syndrome""]",,A cerebral degeneration that results in progressive degeneration of grey matter in the cerebrum and has_symptom convulsions.,false,,,http://purl.obolibrary.org/obo/DOID_1443,,,,,,,,A cerebral degeneration that results in progressive degeneration of grey matter in the cerebrum and has_symptom convulsions.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1442,,,,ICD10CM:G31.81|NCI:C35257|SNOMEDCT_US_2016_03_01:20415001|OMIM:203700|UMLS_CUI:C0205710|MESH:D002549,ALPERS PROGRESSIVE INFANTILE POLIODYSTROPHY|MITOCHONDRIAL DNA DEPLETION SYNDROME 4A|Alpers' disease or gray-matter degeneration|Alper's syndrome|progressive sclerosing poliodystrophy|ALPERS-HUTTENLOCHER SYNDROME,,disease_ontology,,DOID:1442,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Alpers syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100031,"[""L317 in ABL1(F317L)-nonphosphorylated""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100031,,,,,,,,,,,,,,,,,,,,,,,,,,,,L317 in ABL1(F317L)-nonphosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400143,"[""CASK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400143,,,,,,,,,,,,,,,,,,,,,,,,,,,,CASK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003083,"[""uterine wall""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003083,,,,,,,BrendaTissueOBO,,BTO:0003083,,,,,,,,,,,,,,,,,,,uterine wall,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000029,"[""LEU110 in DRAK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000029,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU110 in DRAK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300060,"[""Hydroxycarboxylic acid receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300060,,,,,,,,,,,,,,,,,,,,,,,,,,,,Hydroxycarboxylic acid receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000051,"[""Des-Br-neuropeptide B-23""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000051,,,,,,,,,,,,,,,,,,,,,,,,,,,,Des-Br-neuropeptide B-23,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000215,"[""KIT(A829P) kinase domain""]",,V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; C-Kit; KIT; PBT; SCFR,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; C-Kit; KIT; PBT; SCFR,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000215,,,,,,,,,,,,,,,,,,,200215,,,,,,,,,KIT(A829P) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003566,"[""alphaT3-1 cell""]",,Mouse pituitary tumor cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000756,,,,,,,,Mouse pituitary tumor cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003566,,,,,,,BrendaTissueOBO,,BTO:0003566,,,,,,,,,,,,,,,,,,,alphaT3-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004524,"[""germinal epithelium""]",,Epithelium covering the embryonic genital ridges and the gonads that develop from them.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000416|http://purl.obolibrary.org/obo/BTO_0000514,,,,,,,,Epithelium covering the embryonic genital ridges and the gonads that develop from them.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004524,mgr,2010-02-11T08:34:59Z,,,,,BrendaTissueOBO,surface epithelium,BTO:0004524,,,,,,,,,,,,,,,,,,,germinal epithelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200230,"[""HRH1 gene""]",,"A histamine H1 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35367] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400061,,,,,,,,"A histamine H1 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35367] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200230,,,,,,,,,,,,,,,,3269,HRH1,,,,,,,,,,,HRH1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100113,"[""Dual specificity tyrosine-phosphorylation-regulated kinase 1a""]",,"A dual specificity tyrosine-phosphorylation-regulated kinase 1A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13627] |dual specificity tyrosine-phosphorylation-regulated kinase 1a (DYRK1A)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300266,,,,,,,,"A dual specificity tyrosine-phosphorylation-regulated kinase 1A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13627] |dual specificity tyrosine-phosphorylation-regulated kinase 1a (DYRK1A)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100113,,,,https://pharos.nih.gov/idg/targets/Q13627,,,,,,,,,,,,,DYRK1A,DYRK|MNB|MNBH,,Q13627,,,,,,,,Dual specificity tyrosine-phosphorylation-regulated kinase 1a,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14087,"[""epicondylitis""]",,A bone inflammation disease that results_in inflammation located_in epicondyle.,false,,,http://purl.obolibrary.org/obo/DOID_3342,,,,,,,,A bone inflammation disease that results_in inflammation located_in epicondyle.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14087,,,DOID:14162,MESH:D013716|SNOMEDCT_US_2016_03_01:156659008|UMLS_CUI:C0014488|ICD10CM:M77.1|SNOMEDCT_US_2016_03_01:268088003|SNOMEDCT_US_2016_03_01:24133009|NCI:C35067|SNOMEDCT_US_2016_03_01:73583000|SNOMEDCT_US_2016_03_01:202855006|UMLS_CUI:C0039516|NCI:C34589|ICD9CM:726.32,hockey elbow|andrel epicondylitis|archer's elbow|golfer's elbow|Lateral epicondylitis|medial epicondylitis,,disease_ontology,shooter's elbow|tennis elbow,DOID:14087,,,,,,,,,,,,,,,,,,,epicondylitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14089,"[""root caries""]",,,false,,,http://purl.obolibrary.org/obo/DOID_216,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14089,,,,SNOMEDCT_US_2016_03_01:234975001|MESH:D017213|SNOMEDCT_US_2016_03_01:30512007|UMLS_CUI:C0162644|ICD9CM:521.08,Root caries|Cementum caries|Dental caries of root surface,,disease_ontology,,DOID:14089,,,,,,,,,,,,,,,,,,,root caries,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300324,"[""Other small molecule kinase""]",,"Other small molecule kinase is a kinase enzyme that catalyzes the phosphorylation of a small molecule substrate other than a carbohydrate, nucleoside, nucleotide, lipid, etc.",false,,,http://www.drugtargetontology.org/dto/DTO_03300103,,,,,,,,"Other small molecule kinase is a kinase enzyme that catalyzes the phosphorylation of a small molecule substrate other than a carbohydrate, nucleoside, nucleotide, lipid, etc.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300324,,,,,,,,,,,,,,,,,,,,,,,,,,,,Other small molecule kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4486,"[""malignant biphasic mesothelioma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1790,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4486,,,,UMLS_CUI:C0334515|SNOMEDCT_US_2016_03_01:30383009|NCI:C4282,"mixed Mesothelioma|Mesothelioma, biphasic, malignant (morphologic abnormality)",,disease_ontology,,DOID:4486,,,,,,,,,,,,,,,,,,,malignant biphasic mesothelioma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001019,"[""prostate gland cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001019,,,,,,,BrendaTissueOBO,prostate cell line,BTO:0001019,,,,,,,,,,,,,,,,,,,prostate gland cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6536,"[""plasma cell neoplasm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_706,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6536,,,,UMLS_CUI:C1136084|MESH:D010265|EFO:0000200|SNOMEDCT_US_2016_03_01:277576009|SNOMEDCT_US_2016_03_01:71390001,Plasma cell tumour|Plasmacytic tumor|Plasma cell dyscrasia (disorder),,disease_ontology,,DOID:6536,,,,,,,,,,,,,,,,,,,plasma cell neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060121,"[""integumentary system benign neoplasm""]",,An organ system benign neoplasm located_in the integumentary system organs.,false,,,http://purl.obolibrary.org/obo/DOID_0060085|http://purl.obolibrary.org/obo/DOID_16,,,,,,,,An organ system benign neoplasm located_in the integumentary system organs.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060121,lschriml,2011-07-27T01:49:44Z,,,,,disease_ontology,,DOID:0060121,,,,,,,,,,,,,,,,,,,integumentary system benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060123,"[""connective tissue benign neoplasm""]",,A musculoskeletal system benign neoplasm that is located_in connective tissue.,false,,,http://purl.obolibrary.org/obo/DOID_0060099|http://purl.obolibrary.org/obo/DOID_65,,,,,,,,A musculoskeletal system benign neoplasm that is located_in connective tissue.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060123,lschriml,2011-07-27T02:35:57Z,DOID:177,NCI:C3377|SNOMEDCT_US_2016_03_01:387837005|UMLS_CUI:C0037579|SNOMEDCT_US_2016_03_01:126600002|MESH:D012983,neoplasm of soft tissues|soft tissue benign neoplasm|neoplasm of soft tissue|tumor of the soft tissue,,disease_ontology,,DOID:0060123,,,,,,,,,,,,,,,,,,,connective tissue benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060122,"[""integumentary system cancer""]",,"An organ system cancer that is located_in the skin, hair and nails.",false,,,http://purl.obolibrary.org/obo/DOID_0050686|http://purl.obolibrary.org/obo/DOID_16,,,,,,,,"An organ system cancer that is located_in the skin, hair and nails.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060122,lschriml,2011-07-27T02:31:34Z,,,,,disease_ontology,,DOID:0060122,,,,,,,,,,,,,,,,,,,integumentary system cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100462,"[""Olfactory receptor 6c76""]",,"An olfactory receptor 6C76 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NM76] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6C76 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NM76] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100462,,,,https://pharos.nih.gov/idg/targets/A6NM76,,,,,,,,,,,,,OR6C76,,,A6NM76,,,,,,,,Olfactory receptor 6c76,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200553,"[""OR2V1 gene""]",,"An olfactory receptor 2V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHB1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHB1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200553,,,,,,,,,,,,,,,,26693,OR2V1,,,,,,,,,,,OR2V1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_255,"[""hemangioma""]",,A cell type benign neoplasm that has_physical_basis_in endothelial cells that line blood vessels and is characterised by increased number of normal or abnormal vessels filled with blood.,false,,,http://purl.obolibrary.org/obo/DOID_0060084,,,,,,,,A cell type benign neoplasm that has_physical_basis_in endothelial cells that line blood vessels and is characterised by increased number of normal or abnormal vessels filled with blood.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:255,,,,SNOMEDCT_US_2016_03_01:189194008|UMLS_CUI:C0018916|MESH:D006391|ICD9CM:228.00|ICD9CM:228.0|SNOMEDCT_US_2016_03_01:254822005|SNOMEDCT_US_2016_03_01:189863005|SNOMEDCT_US_2016_03_01:93474003|SNOMEDCT_US_2016_03_01:154625006|SNOMEDCT_US_2016_03_01:189192007|SNOMEDCT_US_2016_03_01:189199003|SNOMEDCT_US_2016_03_01:253053003|ICD10CM:D18.00|SNOMEDCT_US_2016_03_01:400210000|SNOMEDCT_US_2016_03_01:367337005|NCI:C3085|SNOMEDCT_US_2016_03_01:269646001|ICD10CM:D18.0|SNOMEDCT_US_2016_03_01:189193002|SNOMEDCT_US_2016_03_01:2099007,,,disease_ontology,,DOID:255,,,,,,,,,,,,,,,,,,,hemangioma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200253,"[""MC4R gene""]",,"A melanocortin receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32245] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400021,,,,,,,,"A melanocortin receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32245] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200253,,,,,,,,,,,,,,,,4160,MC4R,,,,,,,,,,,MC4R gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005198,"[""adipose-derived stem cell""]",,Most adult stem cells are lineage-restricted (multipotent) and are generally referred to by their tissue origin e.g. adipose-derived stem cell.,false,,,http://purl.obolibrary.org/obo/BTO_0002666|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Most adult stem cells are lineage-restricted (multipotent) and are generally referred to by their tissue origin e.g. adipose-derived stem cell.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005198,XPMUser,2011-09-01T09:15:43Z,,,,,BrendaTissueOBO,,BTO:0005198,,,,,,,,,,,,,,,,,,,adipose-derived stem cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000070,"[""LEU264 in GRK4""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000070,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU264 in GRK4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000421,"[""VAL555 in FGFR3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000421,,,,,,,,,,,,,,,,,,,,,,,,,,,,VAL555 in FGFR3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6364,"[""migraine""]",,"A brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing.",false,,,http://purl.obolibrary.org/obo/DOID_936,,,,,,,,"A brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6364,,,DOID:12437,ICD9CM:346|SNOMEDCT_US_2016_03_01:193041007|SNOMEDCT_US_2016_03_01:37796009|SNOMEDCT_US_2016_03_01:193036004|ICD9CM:346.9|OMIM:613656|ICD10CM:G43.9|UMLS_CUI:C0149931|OMIM:157300|SNOMEDCT_US_2016_03_01:155048007|NCI:C89715|ICD10CM:G43|SNOMEDCT_US_2016_03_01:267699004|SNOMEDCT_US_2016_03_01:155046006|UMLS_CUI:C0042331|SNOMEDCT_US_2016_03_01:193030005|MESH:D008881|EFO:0003821|ICD10CM:G43.909,migraine disorder|migraine variant|migraine with or without aura,,disease_ontology,,DOID:6364,,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,migraine,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100618,"[""Olfactory receptor 5C1""]",,"An olfactory receptor 5C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100618,,,,https://pharos.nih.gov/idg/targets/Q8NGR4,,,,,,,,,,,,,OR5C1,OR5C2P,,Q8NGR4,,,,,,,,Olfactory receptor 5C1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100479,"[""Serine/threonine-protein kinase smg1""]",,"A serine/threonine-protein kinase SMG1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96Q15] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300129,,,,,,,,"A serine/threonine-protein kinase SMG1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96Q15] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100479,,,,https://pharos.nih.gov/idg/targets/Q96Q15,,,,,,,,,,,,,SMG1,ATX|KIAA0421|LIP,,Q96Q15,,,,,,,,Serine/threonine-protein kinase smg1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100371,"[""High affinity nerve growth factor receptor""]",,"high affinity nerve growth factor receptor (TRKA)  with  no mutation  in a nonphosphorylated state|A high affinity nerve growth factor receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P04629] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300200,,,,,,,,"high affinity nerve growth factor receptor (TRKA)  with  no mutation  in a nonphosphorylated state|A high affinity nerve growth factor receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P04629] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100371,,,,https://pharos.nih.gov/idg/targets/P04629,,,,,,,,,,,,,NTRK1,MTC|TRK|TRKA,,P04629,,,,,,,,High affinity nerve growth factor receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100629,"[""Olfactory receptor 5J2""]",,"An olfactory receptor 5J2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH18] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5J2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH18] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100629,,,,https://pharos.nih.gov/idg/targets/Q8NH18,,,,,,,,,,,,,OR5J2,,,Q8NH18,,,,,,,,Olfactory receptor 5J2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2277,"[""gonadal disease""]",,An endocrine system disease that is located_in the gonads.,false,,,http://purl.obolibrary.org/obo/DOID_28,,,,,,,,An endocrine system disease that is located_in the gonads.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2277,,,,MESH:D006058|UMLS_CUI:C0018050|NCI:C26786,,,disease_ontology,,DOID:2277,,,,,,,,,,,,,,,,,,,gonadal disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005375,"[""oral cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005375,XPMUser,2012-09-01T08:01:46Z,,,,,BrendaTissueOBO,,BTO:0005375,,,,,,,,,,,,,,,,,,,oral cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10350,"[""breast cyst""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060082,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10350,,,,NCI:C5315|ICD10CM:N60.0|UMLS_CUI:C0006144|SNOMEDCT_US_2016_03_01:399294002|MESH:D047688|SNOMEDCT_US_2016_03_01:270538000|SNOMEDCT_US_2016_03_01:56726003,Cyst of the breast,,disease_ontology,,DOID:10350,,,,,,,,,,,,,,,,,,,breast cyst,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_27432,"[""alpha-linolenic acid""]","9,12,15-Octadecatrienoic acid|all-cis-9,12,15-octadecatrienoic acid|C18H30O2|ALA|linolenic acid|InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-|(9Z,12Z,15Z)-Octadecatrienoic acid|cis-Delta(9,12,15)-octadecatrienoic acid|278.225|9-cis,12-cis,15-cis-octadecatrienoic acid|(Z,Z,Z)-9,12,15-octadecatrienoic acid|cis,cis,cis-9,12,15-octadecatrienoic acid|278.42960|(9,12,15)-linolenic acid|CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O|0|DTOSIQBPPRVQHS-PDBXOOCHSA-N","A linolenic acid with cis-double bonds at positions 9, 12 and 15. Shown to have an antithrombotic effect.",false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,Wikipedia:Alpha-Linolenic_acid|HMDB:HMDB01388|DrugBank:DB00132|KEGG:C06427|PDBeChem:LNL|Beilstein:1727693|PMID:19269799|MetaCyc:LINOLENIC_ACID|CAS:463-40-1|LIPID_MAPS_instance:LMFA01030152|PMID:24639012|PMID:24320056|Drug_Central:4618|Gmelin:57558|KNApSAcK:C00007247|Reaxys:1727693|PMID:24855655|PMID:11304127|PMID:10232625,"A linolenic acid with cis-double bonds at positions 9, 12 and 15. Shown to have an antithrombotic effect.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:22462|CHEBI:10298|CHEBI:43891,,"(9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid|alpha-linolenic acid|ALPHA-LINOLENIC ACID|alpha-Linolenic acid",,chebi_ontology,"9,12,15-Octadecatrienoic acid|all-cis-9,12,15-octadecatrienoic acid|C18H30O2|ALA|linolenic acid|InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-|(9Z,12Z,15Z)-Octadecatrienoic acid|cis-Delta(9,12,15)-octadecatrienoic acid|278.225|9-cis,12-cis,15-cis-octadecatrienoic acid|(Z,Z,Z)-9,12,15-octadecatrienoic acid|cis,cis,cis-9,12,15-octadecatrienoic acid|278.42960|(9,12,15)-linolenic acid|CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O|0|DTOSIQBPPRVQHS-PDBXOOCHSA-N",,,CHEBI:27432,,,,,,,,,,,,,,,,,,,,,,,CHEBI:27432,,,,,alpha-linolenic acid,,CHEBI:27432,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400032,"[""Cadherin EGF LAG (CELSR) receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400032,,,,,,,,,,,,,,,,,,,,,,,,,,,,Cadherin EGF LAG (CELSR) receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400286,"[""TAK1 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400165,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400286,,,,,,,,,,,,,,,,,,,,,,,,,,,,TAK1 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000068,"[""LEU211 in PIM1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000068,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU211 in PIM1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400577,"[""TRPC1 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400482,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400577,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPC1 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300373,"[""Anion channel tweety (tweety) family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300373,,,,,,,,,,,,,,,,,,,,,,,,,,,,Anion channel tweety (tweety) family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100206,"[""Adhesion G-protein coupled receptor G2""]",,"A G-protein coupled receptor 64 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZP9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,"A G-protein coupled receptor 64 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZP9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100206,,,,https://pharos.nih.gov/idg/targets/Q8IZP9,,,,,,,,,,,,,GPR64,ADGRG2|HE6|TM7LN2,,Q8IZP9,,,,,,,,Adhesion G-protein coupled receptor G2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100200,"[""Potassium voltage-gated channel subfamily f member 1""]",,A voltage-gated potassium channel KCNF1 that is encoded in the genome of human. [] ,false,,,http://www.drugtargetontology.org/dto/DTO_01300548,,,,,,,,A voltage-gated potassium channel KCNF1 that is encoded in the genome of human. [] ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100200,,,,https://pharos.nih.gov/idg/targets/Q9H3M0,,,,,,,,,,,,,KCNF1,,,Q9H3M0,,,,,,,,Potassium voltage-gated channel subfamily f member 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200453,"[""RIPK4 gene""]",,"The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400124,,,,,,,,"The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200453,,,,,,,,,,,,,,,,54101,RIPK4,ANKRD3|DIK,,,,,,,,,,RIPK4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3683,"[""lung benign neoplasm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0050621|http://purl.obolibrary.org/obo/DOID_850,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3683,,,,NCI:C3200|UMLS_CUI:C0024121|MESH:D008175|SNOMEDCT_US_2016_03_01:126713003,tumor of the lung,,disease_ontology,,DOID:3683,,,,,,,,,,,,,,,,,,,lung benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11829,"[""degenerative myopia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_9799|http://purl.obolibrary.org/obo/DOID_11830,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11829,,,,SNOMEDCT_US_2016_03_01:32022003|ICD9CM:360.21|EFO:0004207|SNOMEDCT_US_2016_03_01:193278001|SNOMEDCT_US_2016_03_01:193625005|UMLS_CUI:C0154778|SNOMEDCT_US_2016_03_01:193276002|ICD10CM:H44.2|MESH:D047728,progressive high (degenerative) myopia|progressive high myopia|degenerative progressive high myopia|pathological myopia,,disease_ontology,,DOID:11829,,,,,,,,,,,,,,,,,,,degenerative myopia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000068,"[""amniotic fluid""]",,"Fluid within the amniotic cavity produced by the amnion during the early embryonic period, and later by the lungs and kidneys; at first crystal clear, it later becomes cloudy. It protects the embryo and fetus from injury. The amount at term normally varies from 500 to 1500 mL.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Fluid within the amniotic cavity produced by the amnion during the early embryonic period, and later by the lungs and kidneys; at first crystal clear, it later becomes cloudy. It protects the embryo and fetus from injury. The amount at term normally varies from 500 to 1500 mL.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000068,,,,,,,BrendaTissueOBO,acqua amnii|liquor amnii,BTO:0000068,,,,,,,,,,,,,,,,,,,amniotic fluid,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200094,"[""CATSPER2 gene""]",,"Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_01400345,,,,,,,,"Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200094,,,,,,,,,,,,,,,,117155,CATSPER2,,,,,,,,,,,CATSPER2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4919,"[""renal pelvis carcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_263,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4919,,,DOID:12343,ICD10CM:C65|SNOMEDCT_US_2016_03_01:363457009|UMLS_CUI:C0153618|NCI:C6142|SNOMEDCT_US_2016_03_01:93985007|ICD9CM:189.1|NCI:C7525|SNOMEDCT_US_2016_03_01:188254006|UMLS_CUI:C1335749,renal pelvis cancer|malignant neoplasm of renal pelvis|malignant tumor of renal pelvis (disorder)|malignant neoplasm of renal pelvis NOS (disorder)|carcinoma of kidney Pelvis|malignant renal Pelvis neoplasm,,disease_ontology,,DOID:4919,,,,,,,,,,,,,,,,,,,renal pelvis carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000237,"[""LKB1 kinase domain""]",,Serine/threonine kinase 11; LKB1; PJS; STK11,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine kinase 11; LKB1; PJS; STK11,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000237,,,,,,,,,,,,,,,,,,,200227,,,,,,,,,LKB1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100597,"[""Adenylate kinase isoenzyme 6""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100597,,,,,,,,,,,,,,,,,AK6,,,Q9Y3D8,,,,,,,,Adenylate kinase isoenzyme 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100267,"[""P2X purinoceptor 4""]",,"A P2X purinoceptor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99571] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300364,,,,,,,,"A P2X purinoceptor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99571] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100267,,,,https://pharos.nih.gov/idg/targets/Q99571,,,,,,,,,,,,,P2RX4,,,Q99571,,,,,,,,P2X purinoceptor 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13533,"[""osteopetrosis""]",,An osteosclerosis that has_material_basis_in lack of bone resorption which results_in abnormally hard and brittle bones.,false,,,http://purl.obolibrary.org/obo/DOID_4254,,,,,,,,An osteosclerosis that has_material_basis_in lack of bone resorption which results_in abnormally hard and brittle bones.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13533,,,,SNOMEDCT_US_2016_03_01:1926006|SNOMEDCT_US_2016_03_01:205500005|SNOMEDCT_US_2016_03_01:360504006|OMIM:612301|ORDO:667|SNOMEDCT_US_2016_03_01:63941000|OMIM:259730|OMIM:611497|OMIM:259700|OMIM:259720|NCI:C26840|MESH:D010022|OMIM:611490|OMIM:607634|OMIM:615085|SNOMEDCT_US_2016_03_01:367489004|SNOMEDCT_US_2016_03_01:205502002|UMLS_CUI:C0029454|OMIM:259710|OMIM:166600|ICD9CM:756.52|ICD10CM:Q78.2,marble bone|Albers-Schonberg disease,,disease_ontology,,DOID:13533,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping submitted by NeuroDevNet. [LS].",,osteopetrosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000221,"[""MET92 in OSR1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000221,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET92 in OSR1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200547,"[""TTK gene""]",,"This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400240,,,,,,,,"This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200547,,,,,,,,,,,,,,,,7272,TTK,MPS1|MPS1L1,,,,,,,,,,TTK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400148,"[""DDR family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400148,,,,,,,,,,,,,,,,,,,,,,,,,,,,DDR family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100431,"[""Olfactory receptor 52n2""]",,"An olfactory receptor 52N2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 52N2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100431,,,,https://pharos.nih.gov/idg/targets/Q8NGI0,,,,,,,,,,,,,OR52N2,,,Q8NGI0,,,,,,,,Olfactory receptor 52n2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3996,"[""urinary system cancer""]",,"An organ system cancer that is located_in the kidneys, ureteres, bladder or urethra.",false,,,http://purl.obolibrary.org/obo/DOID_18|http://purl.obolibrary.org/obo/DOID_0050686,,,,,,,,"An organ system cancer that is located_in the kidneys, ureteres, bladder or urethra.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3996,,,,UMLS_CUI:C0348371|ICD9CM:189.9|ICD10CM:C68.9|SNOMEDCT_US_2016_03_01:448233000|SNOMEDCT_US_2016_03_01:190132004,,,disease_ontology,,DOID:3996,,,,,,,,,,,,,,,,,,,urinary system cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100276,"[""Polycystic kidney disease protein 1-like 2""]",,"A polycystic kidney disease protein 1-like 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z442] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300367,,,,,,,,"A polycystic kidney disease protein 1-like 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z442] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100276,,,,https://pharos.nih.gov/idg/targets/Q7Z442,,,,,,,,,,,,,PKD1L2,KIAA1879|PC1L2,,Q7Z442,,,,,,,,Polycystic kidney disease protein 1-like 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002845,"[""mammary duct""]",,Channel conveying the milk secreted by the lobes of the breast to and through the nipples.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Channel conveying the milk secreted by the lobes of the breast to and through the nipples.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002845,,,,,,,BrendaTissueOBO,lactiferous duct|ductus lactiferi|galactophorous tubule|lactiferous tubule,BTO:0002845,,,,,,,,,,,,,,,,,,,mammary duct,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100559,"[""Olfactory receptor 2Y1""]",,"An olfactory receptor 2Y1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGV0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2Y1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGV0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100559,,,,https://pharos.nih.gov/idg/targets/Q8NGV0,,,,,,,,,,,,,OR2Y1,,,Q8NGV0,,,,,,,,Olfactory receptor 2Y1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200169,"[""KCNAB1 gene""]",,"Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms which are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400356,,,,,,,,"Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms which are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200169,,,,,,,,,,,,,,,,7881,KCNAB1,KCNA1B,,,,,,,,,,KCNAB1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400547,"[""Kv4.3/KCND3 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400444,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400547,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv4.3/KCND3 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003536,"[""NCI-H522 cell""]",,Human non-small cell lung cancer adenocarcinoma cell line. This line was derived from a lung cancer obtained from a 60 years old caucasian male patient prior to therapy.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002553,,,,,,,,Human non-small cell lung cancer adenocarcinoma cell line. This line was derived from a lung cancer obtained from a 60 years old caucasian male patient prior to therapy.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003536,,,,,,,BrendaTissueOBO,H-522 cell|H522 cell,BTO:0003536,,,,,,,,,,,,,,,,,,,NCI-H522 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11633,"[""thyroid hormone resistance syndrome""]",,OMIM mapping confirmed by DO. [LS].,false,,,http://purl.obolibrary.org/obo/DOID_1459,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11633,,,,OMIM:188570|SNOMEDCT_US_2016_03_01:111567006|UMLS_CUI:C2940786|OMIM:274300|NCI:C85191|SNOMEDCT_US_2016_03_01:237559000|MESH:D018382|SNOMEDCT_US_2016_03_01:237560005|SNOMEDCT_US_2016_03_01:50375007,Thyroid hormone responsiveness defect (disorder)|Thyroid hormone resistance syndrome (disorder)|Refetoff syndrome (disorder)|Generalized thyroid hormone resistance (disorder)|thyroid hormone resistance,,disease_ontology,,DOID:11633,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,thyroid hormone resistance syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11634,"[""myxedema""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_1459,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11634,,,,SNOMEDCT_US_2016_03_01:190274003|SNOMEDCT_US_2016_03_01:154660000|UMLS_CUI:C0027145|MESH:D009230|ICD10CM:E03.9|OMIM:255900|NCI:C34834|SNOMEDCT_US_2016_03_01:43153006|SNOMEDCT_US_2016_03_01:267465007,,,disease_ontology,,DOID:11634,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,myxedema,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100615,"[""Olfactory receptor 5b12""]",,"An olfactory receptor 5B12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R08] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5B12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R08] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100615,,,,https://pharos.nih.gov/idg/targets/Q96R08,,,,,,,,,,,,,OR5B12,OR5B12P|OR5B16,,Q96R08,,,,,,,,Olfactory receptor 5b12,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001780,"[""oxyntic cell""]",,Cells of the gastric glands which secrete hydrochloric acid and intrinsic factor.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Cells of the gastric glands which secrete hydrochloric acid and intrinsic factor.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001780,,,,,,,BrendaTissueOBO,parietal cell,BTO:0001780,,,,,,,,,,,,,,,,,,,oxyntic cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100730,"[""P2Y purinoceptor 8""]",,"A P2Y purinoceptor 8 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86VZ1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300100,,,,,,,,"A P2Y purinoceptor 8 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86VZ1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100730,,,,https://pharos.nih.gov/idg/targets/Q86VZ1,,,,,,,,,,,,,P2RY8,,,Q86VZ1,,,,,,,,P2Y purinoceptor 8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200016,"[""ADCK4 gene""]",,"This gene encodes a protein with two copies of a domain found in protein kinases. The encoded protein has a complete protein kinase catalytic domain, and a truncated domain that contains only the active and binding sites of the protein kinase domain, however, it is not known whether the protein has any kinase activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400249,,,,,,,,"This gene encodes a protein with two copies of a domain found in protein kinases. The encoded protein has a complete protein kinase catalytic domain, and a truncated domain that contains only the active and binding sites of the protein kinase domain, however, it is not known whether the protein has any kinase activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200016,,,,,,,,,,,,,,,,79934,ADCK4,,,,,,,,,,,ADCK4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005096,"[""epithelial stem cell""]",,"Epithelial stem cells in the lining of the digestive tract occur in deep crypts and give rise to several cell types: absorptive cells, goblet cells, paneth cells, and enteroendocrine cells.",false,,,http://purl.obolibrary.org/obo/BTO_0002666|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Epithelial stem cells in the lining of the digestive tract occur in deep crypts and give rise to several cell types: absorptive cells, goblet cells, paneth cells, and enteroendocrine cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005096,XPMUser,2011-03-21T08:23:48Z,,,,,BrendaTissueOBO,,BTO:0005096,,,,,,,,,,,,,,,,,,,epithelial stem cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13223,"[""uterine fibroid""]",,A uterine benign neoplasm derived from the smooth muscle layer of the uterus.,false,,,http://purl.obolibrary.org/obo/DOID_0060095|http://purl.obolibrary.org/obo/DOID_0050871,,,,,,,,A uterine benign neoplasm derived from the smooth muscle layer of the uterus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13223,,,,MESH:D007889|ICD10CM:D25|ICD10CM:D25.9|SNOMEDCT_US_2016_03_01:189106003|SNOMEDCT_US_2016_03_01:44598004|SNOMEDCT_US_2016_03_01:146801000119103|ICD9CM:218.9|UMLS_CUI:C0042133|EFO:0000731|OMIM:150699|SNOMEDCT_US_2016_03_01:154616000|NCI:C3434|SNOMEDCT_US_2016_03_01:95315005|ICD9CM:218|HP:0000131,leiomyoma of Corpus Uteri|uterine leiomyoma|UTERUS FIBROMA|Plexiform leiomyoma,,disease_ontology,,DOID:13223,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,uterine fibroid,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100341,"[""Serine/threonine-protein kinase mrck alpha""]",,"serine/threonine-protein kinase mrck alpha (MRCKA)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase MRCK alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5VT25] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300265,,,,,,,,"serine/threonine-protein kinase mrck alpha (MRCKA)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase MRCK alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5VT25] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100341,,,,https://pharos.nih.gov/idg/targets/Q5VT25,,,,,,,,,,,,,CDC42BPA,KIAA0451,,Q5VT25,,,,,,,,Serine/threonine-protein kinase mrck alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200495,"[""STK10 gene""]",,"This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400315,,,,,,,,"This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200495,,,,,,,,,,,,,,,,6793,STK10,LOK,,,,,,,,,,STK10 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200511,"[""STYK1 gene""]",,"Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400230,,,,,,,,"Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200511,,,,,,,,,,,,,,,,55359,STYK1,NOK,,,,,,,,,,STYK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4680,"[""breast metaplastic carcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3459,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4680,,,,UMLS_CUI:C1334708|NCI:C5164,Metaplastic carcinoma of the breast,,disease_ontology,metaplastic carcinoma of breast,DOID:4680,,,,,,,,,,,,,,,,,,,breast metaplastic carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100369,"[""Olfactory receptor 2t11""]",,"An olfactory receptor 2T11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH01] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2T11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH01] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100369,,,,https://pharos.nih.gov/idg/targets/Q8NH01,,,,,,,,,,,,,OR2T11,,,Q8NH01,,,,,,,,Olfactory receptor 2t11,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491009,"[""PI3/PI4 kinase family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400323,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491009,,,,,,,,,,,,,,,,,,,,,,,,,,,,PI3/PI4 kinase family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000098,"[""Wnt-4""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000098,,,,,,,,,,,,,,,,,,,,,,,,,,,,Wnt-4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2533,"[""splenic infarction""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2529,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2533,,,,UMLS_CUI:C0037998|ICD10CM:D73.5|SNOMEDCT_US_2016_03_01:154839008|MESH:D013159|SNOMEDCT_US_2016_03_01:267570002|SNOMEDCT_US_2016_03_01:22996003,Splenic infarction|Splenic infarct|Splenic infarction (disorder),,disease_ontology,,DOID:2533,,,,,,,,,,,,,,,,,,,splenic infarction,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000322,"[""OSR1 kinase domain""]",,Serine/threonine-protein kinase OSR1; oxidative-stress responsive 1; KIAA1101; OSR1; OXSR1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase OSR1; oxidative-stress responsive 1; KIAA1101; OSR1; OXSR1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000322,,,,,,,,,,,,,,,,,,,200297,,,,,,,,,OSR1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200053,"[""CALHM2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400335,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200053,,,,,,,,,,,,,,,,51063,CALHM2,FAM26B,,,,,,,,,,CALHM2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9279,"[""hyperhomocysteinemia""]",,An amino acid metabolic disorder that involves an abnormally large level of homocysteine in the blood.,false,,,http://purl.obolibrary.org/obo/DOID_9252,,,,,,,,An amino acid metabolic disorder that involves an abnormally large level of homocysteine in the blood.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9279,,,,UMLS_CUI:C0598608|SNOMEDCT_US_2016_03_01:419503008|MESH:D020138|NCI:C84770,,,disease_ontology,,DOID:9279,,,,,,,,,,,,,,,,,,,hyperhomocysteinemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001296,"[""sprout""]",,A young shoot (as from a seed or root).,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A young shoot (as from a seed or root).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001296,,,,,,,BrendaTissueOBO,,BTO:0001296,,,,,,,,,,,,,,,,,,,sprout,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400109,"[""AGC group gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400102,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400109,,,,,,,,,,,,,,,,,,,,,,,,,,,,AGC group gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002324,"[""merocrine gland""]",,One in which the secretory cells maintain their integrity throughout the secretory cycle.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000522,,,,,,,,One in which the secretory cells maintain their integrity throughout the secretory cycle.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002324,,,,,,,BrendaTissueOBO,,BTO:0002324,,,,,,,,,,,,,,,,,,,merocrine gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1492,"[""eye and adnexa disease""]",,A sensory system disease that is located_in the eye or the adnexa of the eye.,false,,,http://purl.obolibrary.org/obo/DOID_0050155,,,,,,,,A sensory system disease that is located_in the eye or the adnexa of the eye.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1492,,,,UMLS_CUI:C0004608|ICD9CM:362.10|SNOMEDCT_US_2016_03_01:42873008|SNOMEDCT_US_2016_03_01:31411005|ICD10CM:H35.00|SNOMEDCT_US_2016_03_01:193355009,,,disease_ontology,,DOID:1492,,,,,,,,,,,,,,,,,,,eye and adnexa disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000154,"[""FAK1 kinase domain""]",,PTK2 protein tyrosine kinase 2; FADK; FAK; FAK1; FRNK; pp125FAK; PTK2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,PTK2 protein tyrosine kinase 2; FADK; FAK; FAK1; FRNK; pp125FAK; PTK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000154,,,,,,,,,,,,,,,,,,,200158,,,,,,,,,FAK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100142,"[""Serine/threonine-protein kinase/endoribonuclease ire1""]",,A serine/threonine-protein kinase/endoribonuclease IRE1 that is encoded in the genome of human. [Reactome:REACT_18666] |serine/threonine-protein kinase/endoribonuclease ire1 (ERN1)  with  no mutation  in a nonphosphorylated state,false,,,http://www.drugtargetontology.org/dto/DTO_03300154,,,,,,,,A serine/threonine-protein kinase/endoribonuclease IRE1 that is encoded in the genome of human. [Reactome:REACT_18666] |serine/threonine-protein kinase/endoribonuclease ire1 (ERN1)  with  no mutation  in a nonphosphorylated state,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100142,,,,https://pharos.nih.gov/idg/targets/O75460,,,,,,,,,,,,,ERN1,IRE1,,O75460,,,,,,,,Serine/threonine-protein kinase/endoribonuclease ire1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100168,"[""G-protein coupled receptor 182""]",,"A G-protein coupled receptor 182 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O15218] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300054,,,,,,,,"A G-protein coupled receptor 182 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O15218] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100168,,,,https://pharos.nih.gov/idg/targets/O15218,,,,,,,,,,,,,GPR182,ADMR,,O15218,,,,,,,,G-protein coupled receptor 182,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000016,"[""GLY866 in BUB1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29947,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000016,,,,,,,,,,,,,,,,,,,,,,,,,,,,GLY866 in BUB1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000405,"[""penis""]",,A male organ of copulation that in male mammals including humans usually functions as the channel by which urine leaves the body.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003097,,,,,,,,A male organ of copulation that in male mammals including humans usually functions as the channel by which urine leaves the body.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000405,,,,,,,BrendaTissueOBO,phallus,BTO:0000405,,,,,,,,,,,,,,,,,,,penis,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400370,"[""Sodium channel auxiliary subunit 1-4 (sca-) family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400370,,,,,,,,,,,,,,,,,,,,,,,,,,,,Sodium channel auxiliary subunit 1-4 (sca-) family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300441,"[""KCNMB/KCNMB4 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300358,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300441,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNMB/KCNMB4 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80263,"[""Leu-enkephalin""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80263,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80263,,,,,Leu-enkephalin,,CHEBI:80263,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001289,"[""squamous cell carcinoma cell""]",,"Carcinoma developed from squamous epithelium, having cuboid cells and characterized by keratinization and often by preservation of intercellular bridges. Initially local and superficial, the lesion may later invade and metastasize.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Carcinoma developed from squamous epithelium, having cuboid cells and characterized by keratinization and often by preservation of intercellular bridges. Initially local and superficial, the lesion may later invade and metastasize.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001289,,,,,,,BrendaTissueOBO,epidermoid carcinoma cell|prickle cell carcinoma cell|SCC cell,BTO:0001289,,,,,,,,,,,,,,,,,,,squamous cell carcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100729,"[""P2y purinoceptor 6""]",,"A P2Y purinoceptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15077] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300100,,,,,,,,"A P2Y purinoceptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15077] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100729,,,,https://pharos.nih.gov/idg/targets/Q15077,,,,,,,,,,,,,P2RY6,,,Q15077,,,,,,,,P2y purinoceptor 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000811,"[""ovary cancer cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0000977|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000811,,,,,,,BrendaTissueOBO,ovarian cancer cell line|ovarian carcinoma cell line,BTO:0000811,,,,,,,,,,,,,,,,,,,ovary cancer cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000518,"[""gill""]",,A paired respiratory organ in fishes consisting of gill filaments on the gill arch in the posterior portion of the head and usually providing the primary exchange of gases between the blood and the surrounding water.,false,,,http://purl.obolibrary.org/obo/BTO_0000203|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A paired respiratory organ in fishes consisting of gill filaments on the gill arch in the posterior portion of the head and usually providing the primary exchange of gases between the blood and the surrounding water.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000518,,,,,,,BrendaTissueOBO,branchial tissue|branchia,BTO:0000518,,,,,,,,,,,,,,,,,,,gill,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_30015,"[""L-valine residue""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_33700,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:30015,,,,RESID:AA0020,L-valine residue,,chebi_ontology,Val|99.13110|L-valine|99.068|L-valyl|C5H9NO|V|0|-Val-,CHEBI:30015,http://purl.obolibrary.org/obo/chebi#3_STAR,,,,,,,,,,,,,,,,,,L-valine residue,,,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100324,"[""Short transient receptor potential channel 6""]",,"A short transient receptor potential channel 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y210] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300581,,,,,,,,"A short transient receptor potential channel 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y210] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100324,,,,https://pharos.nih.gov/idg/targets/Q9Y210,,,,,,,,,,,,,TRPC6,TRP6,,Q9Y210,,,,,,,,Short transient receptor potential channel 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200715,"[""OR9G4 gene""]",,"An olfactory receptor 9G4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 9G4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200715,,,,,,,,,,,,,,,,283189,OR9G4,,,,,,,,,,,OR9G4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200790,"[""TAS2R46 gene""]",,"A taste receptor type 2 member 46 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59540] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400014,,,,,,,,"A taste receptor type 2 member 46 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59540] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200790,,,,,,,,,,,,,,,,259292,TAS2R46,,,,,,,,,,,TAS2R46 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000328,"[""PAK7 kinase domain""]",,P21 protein (Cdc42/Rac)-activated kinase 7; KIAA1264; MGC26232; PAK5; PAK7,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,P21 protein (Cdc42/Rac)-activated kinase 7; KIAA1264; MGC26232; PAK5; PAK7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000328,,,,,,,,,,,,,,,,,,,"200307, 200308",,,,,,,,,PAK7 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100186,"[""Probable g-protein coupled receptor 25""]",,"A G-protein coupled receptor 25 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00155] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300023,,,,,,,,"A G-protein coupled receptor 25 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00155] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100186,,,,https://pharos.nih.gov/idg/targets/O00155,,,,,,,,,,,,,GPR25,,,O00155,,,,,,,,Probable g-protein coupled receptor 25,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000246,"[""M3K5 kinase domain""]",,Mitogen-activated protein kinase kinase kinase 5; ASK; ASK/MAP3K5; ASK1; MAP3K5; MAPKKK5; MEKK5,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase kinase kinase 5; ASK; ASK/MAP3K5; ASK1; MAP3K5; MAPKKK5; MEKK5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000246,,,,,,,,,,,,,,,,,,,200042,,,,,,,,,M3K5 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100309,"[""Microtubule-associated serine/threonine-protein kinase 4""]",,"A microtubule-associated serine/threonine-protein kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15021] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300160,,,,,,,,"A microtubule-associated serine/threonine-protein kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15021] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100309,,,,https://pharos.nih.gov/idg/targets/O15021,,,,,,,,,,,,,MAST4,KIAA0303,,O15021,,,,,,,,Microtubule-associated serine/threonine-protein kinase 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12129,"[""bulimia nervosa""]",,An eating disorder characterized by the restraining of food intake for a period of time followed by an over intake or binging period that results in feelings of guilt and low self-esteem.,false,,,http://purl.obolibrary.org/obo/DOID_8670,,,,,,,,An eating disorder characterized by the restraining of food intake for a period of time followed by an over intake or binging period that results in feelings of guilt and low self-esteem.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12129,,,,OMIM:610269|SNOMEDCT_US_2016_03_01:78004001|OMIM:607499|SNOMEDCT_US_2016_03_01:192013000|SNOMEDCT_US_2016_03_01:206939001|MESH:D002032|UMLS_CUI:C0006370|SNOMEDCT_US_2016_03_01:192447005|NCI:C97162|ICD10CM:F50.2,hyperorexia nervosa,,disease_ontology,,DOID:12129,,,,,,,,,,,,,,,,,Xref MGI.,,bulimia nervosa,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12120,"[""pulmonary alveolar proteinosis""]",,"A lung disease that is characterized by abnormal accumulation of surfactant occurs within the alveoli, interfering with gas exchange.",false,,,http://purl.obolibrary.org/obo/DOID_850,,,,,,,,"A lung disease that is characterized by abnormal accumulation of surfactant occurs within the alveoli, interfering with gas exchange.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12120,,,,OMIM:300770|MESH:D011649|ICD9CM:516.0|ICD10CM:J84.01|ORDO:264675|UMLS_CUI:C0034050|OMIM:265120|OMIM:614370|OMIM:610921|OMIM:610913|NCI:C85037|SNOMEDCT_US_2016_03_01:10501004,,,disease_ontology,,DOID:12120,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,pulmonary alveolar proteinosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060119,"[""pharynx cancer""]",,A gastrointestinal system cancer that is located_in the pharynx.,false,,,http://purl.obolibrary.org/obo/DOID_3119,,,,,,,,A gastrointestinal system cancer that is located_in the pharynx.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060119,lschriml,2011-07-27T01:26:34Z,,UMLS_CUI:C0031347|SNOMEDCT_US_2016_03_01:126685009|SNOMEDCT_US_2016_03_01:95001001|NCI:C3325|MESH:D010610,pharyngeal neoplasm|pharynx neoplasm,,disease_ontology,pharyngeal cancer,DOID:0060119,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,pharynx cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060118,"[""thoracic disease""]",,A disease of anatomical entity that is located_in the thoracic cavity.,false,,,http://purl.obolibrary.org/obo/DOID_7,,,,,,,,A disease of anatomical entity that is located_in the thoracic cavity.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060118,lschriml,2011-07-25T02:23:47Z,,,,,disease_ontology,,DOID:0060118,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,thoracic disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060115,"[""nervous system benign neoplasm""]",,An organ system benign neoplasm that is located_in the central nervous system or located_in the peripheral nervous system.,false,,,http://purl.obolibrary.org/obo/DOID_0060085,,,,,,,,An organ system benign neoplasm that is located_in the central nervous system or located_in the peripheral nervous system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060115,lschriml,2011-07-25T12:47:43Z,,,,,disease_ontology,,DOID:0060115,,,,,,,,,,,,,,,,,,,nervous system benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060116,"[""sensory system cancer""]",,A nervous system cancer that is located_in the sensory system.,false,,,http://purl.obolibrary.org/obo/DOID_0050155|http://purl.obolibrary.org/obo/DOID_3093,,,,,,,,A nervous system cancer that is located_in the sensory system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060116,lschriml,2011-07-25T01:51:56Z,,,,,disease_ontology,,DOID:0060116,,,,,,,,,,,,,,,,,,,sensory system cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491040,"[""Ephrin family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491040,,,,,,,,,,,,,,,,,,,,,,,,,,,,Ephrin family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001079,"[""trophoblast""]",,A thin layer of ectoderm that forms the wall of many mammalian blastulas and functions in the nutrition and implantation of the embryo.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A thin layer of ectoderm that forms the wall of many mammalian blastulas and functions in the nutrition and implantation of the embryo.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001079,,,,,,,BrendaTissueOBO,trophoderm,BTO:0001079,,,,,,,,,,,,,,,,,,,trophoblast,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200468,"[""OPRD1 gene""]",,"A delta-type opioid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41143] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A delta-type opioid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41143] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200468,,,,,,,,,,,,,,,,4985,OPRD1,OPRD,,,,,,,,,,OPRD1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000055,"[""BRAF(V600E) kinase domain""]",,V-raf murine sarcoma viral oncogene homolog B1; BRAF; BRAF1; B-RAF1; FLJ95109; MGC126806; MGC138284; RAFB1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,V-raf murine sarcoma viral oncogene homolog B1; BRAF; BRAF1; B-RAF1; FLJ95109; MGC126806; MGC138284; RAFB1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000055,,,,,,,,,,,,,,,,,,,200055,,,,,,,,,BRAF(V600E) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200255,"[""RPS6KA5 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400281,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200255,,,,,,,,,,,,,,,,9252,RPS6KA5,MSK1,,,,,,,,,,RPS6KA5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000220,"[""KIT(V559D,T670I) kinase domain""]",,V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; C-Kit; KIT; PBT; SCFR,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; C-Kit; KIT; PBT; SCFR,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000220,,,,,,,,,,,,,,,,,,,200220,,,,,,,,,"KIT(V559D,T670I) kinase domain",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001779,"[""palate""]",,The roof of the mouth separating the mouth from the nasal cavity.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The roof of the mouth separating the mouth from the nasal cavity.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001779,,,,,,,BrendaTissueOBO,,BTO:0001779,,,,,,,,,,,,,,,,,,,palate,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200145,"[""GPR139 gene""]",,"A G-protein coupled receptor 139 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q6DWJ6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 139 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q6DWJ6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200145,,,,,,,,,,,,,,,,124274,GPR139,GPRG1|PGR3,,,,,,,,,,GPR139 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200112,"[""DSTYK gene""]",,"This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400149,,,,,,,,"This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200112,,,,,,,,,,,,,,,,25778,DSTYK,KIAA0472|RIP5|RIPK5,,,,,,,,,,DSTYK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002263,"[""ventriculus""]",," 1. A hollow digestive organ, especially the stomach of certain insects or the gizzard of a bird.  2. The digestive cavity in the body of a sponge.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,," 1. A hollow digestive organ, especially the stomach of certain insects or the gizzard of a bird.  2. The digestive cavity in the body of a sponge.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002263,,,,,,,BrendaTissueOBO,,BTO:0002263,,,,,,,,,,,,,,,,,,,ventriculus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200043,"[""CACNA1F gene""]",,"This gene encodes a multipass transmembrane protein that functions as an alpha-1 subunit of the voltage-dependent calcium channel, which mediates the influx of calcium ions into the cell. The encoded protein forms a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Mutations in this gene can cause X-linked eye disorders, including congenital stationary night blindness type 2A, cone-rod dystropy, and Aland Island eye disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_01400386,,,,,,,,"This gene encodes a multipass transmembrane protein that functions as an alpha-1 subunit of the voltage-dependent calcium channel, which mediates the influx of calcium ions into the cell. The encoded protein forms a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Mutations in this gene can cause X-linked eye disorders, including congenital stationary night blindness type 2A, cone-rod dystropy, and Aland Island eye disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200043,,,,,,,,,,,,,,,,778,CACNA1F,CACNAF1,,,,,,,,,,CACNA1F gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_543,"[""dystonia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_480,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:543,,,DOID:544,NCI:C34563|ICD10CM:G24|MESH:D004421|UMLS_CUI:C0393593|SNOMEDCT_US_2016_03_01:250068003|SNOMEDCT_US_2016_03_01:194478005|SNOMEDCT_US_2016_03_01:15802004|SNOMEDCT_US_2016_03_01:192863009|UMLS_CUI:C0013421|MESH:D020821|ICD10CM:G24.9,dystonic disease,,disease_ontology,,DOID:543,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,dystonia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_540,"[""strabismus""]",,,false,,,http://purl.obolibrary.org/obo/DOID_9834|http://purl.obolibrary.org/obo/DOID_1279,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:540,,,,ICD10CM:H50.89|UMLS_CUI:C0029831|SNOMEDCT_US_2016_03_01:194651002|SNOMEDCT_US_2016_03_01:194128003|ICD9CM:378.7|ICD10CM:H50.8|SNOMEDCT_US_2016_03_01:194125000,,,disease_ontology,,DOID:540,,,,,,,,,,,,,,,,,,,strabismus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5572,"[""Beckwith-Wiedemann syndrome""]",,"A syndrome characterized by overgrowth (macrosomia), an increased risk of childhood cancer and congenital malformations.",false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,"A syndrome characterized by overgrowth (macrosomia), an increased risk of childhood cancer and congenital malformations.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5572,,,,OMIM:130650|SNOMEDCT_US_2016_03_01:81780002|ICD10CM:Q87.3|ORDO:116|UMLS_CUI:C0004903|NCI:C34415|MESH:D001506,,,disease_ontology,,DOID:5572,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Beckwith-Wiedemann syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004696,"[""external carotid artery""]",,"In human anatomy, the external carotid artery is a major artery of the head and neck. It arises from the common carotid artery when it bifurcates into the external and internal carotid artery.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"In human anatomy, the external carotid artery is a major artery of the head and neck. It arises from the common carotid artery when it bifurcates into the external and internal carotid artery.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004696,mgr,2010-05-14T01:56:27Z,,,,,BrendaTissueOBO,,BTO:0004696,,,,,,,,,,,,,,,,,,,external carotid artery,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200057,"[""CDK10 gene""]",,"The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03491033,,,,,,,,"The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200057,,,,,,,,,,,,,,,,8558,CDK10,,,,,,,,,,,CDK10 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100182,"[""Potassium voltage-gated channel subfamily A member 3""]",,"A voltage-gated potassium channel subunit KCNA3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P22001] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300534,,,,,,,,"A voltage-gated potassium channel subunit KCNA3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P22001] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100182,,,,https://pharos.nih.gov/idg/targets/P22001,,,,,,,,,,,,,KCNA3,HGK5,,P22001,,,,,,,,Potassium voltage-gated channel subfamily A member 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200345,"[""MTOR gene""]",,"The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03491035,,,,,,,,"The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200345,,,,,,,,,,,,,,,,2475,MTOR,FRAP|FRAP1|FRAP2|RAFT1,,,,,,,,,,MTOR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001106,"[""T-cell acute lymphoblastic leukemia cell""]",,"A type of acute lymphoblastic leukaemia, ALL, a cancer of the lymphocyte-forming cells called lymphoblasts.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000731,,,,,,,,"A type of acute lymphoblastic leukaemia, ALL, a cancer of the lymphocyte-forming cells called lymphoblasts.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001106,,,,,,,BrendaTissueOBO,"acute T-lymphocytic leukemia cell|T-ALL cell|acute lymphoblastic leukemia cell, T-cell type|T-cell leukemia cell",BTO:0001106,,,,,,,,,,,,,,,,,,,T-cell acute lymphoblastic leukemia cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001262,"[""soft body part""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001262,,,,,,,BrendaTissueOBO,Weichteil,BTO:0001262,,,,,,,,,,,,,,,,,,,soft body part,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003907,"[""uroepithelial cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003907,,,,,,,BrendaTissueOBO,urothelial cell line,BTO:0003907,,,,,,,,,,,,,,,,,,,uroepithelial cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100673,"[""Olfactory receptor 6y1""]",,"An olfactory receptor 6Y1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6Y1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100673,,,,https://pharos.nih.gov/idg/targets/Q8NGX8,,,,,,,,,,,,,OR6Y1,OR6Y2,,Q8NGX8,,,,,,,,Olfactory receptor 6y1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400484,"[""TrpV subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400360,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400484,,,,,,,,,,,,,,,,,,,,,,,,,,,,TrpV subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100543,"[""Olfactory receptor 2M7""]",,"An olfactory receptor 2M7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG81] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2M7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG81] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100543,,,,https://pharos.nih.gov/idg/targets/Q8NG81,,,,,,,,,,,,,OR2M7,,,Q8NG81,,,,,,,,Olfactory receptor 2M7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100051,"[""Voltage-dependent l-type calcium channel subunit beta-4""]",,"A voltage-dependent L-type calcium channel subunit beta-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00305] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300334,,,,,,,,"A voltage-dependent L-type calcium channel subunit beta-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00305] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100051,,,,https://pharos.nih.gov/idg/targets/O00305,,,,,,,,,,,,,CACNB4,CACNLB4,,O00305,,,,,,,,Voltage-dependent l-type calcium channel subunit beta-4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001719,"[""claw""]",,"1. A sharp, curved, horny structure at the end of a toe of a mammal, reptile, or bird. 2. A chela or similar pincerlike structure on the end of a limb of a crustacean or other arthropod. 3. A limb terminating in such a structure.",false,,,http://purl.obolibrary.org/obo/BTO_0001492|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"1. A sharp, curved, horny structure at the end of a toe of a mammal, reptile, or bird. 2. A chela or similar pincerlike structure on the end of a limb of a crustacean or other arthropod. 3. A limb terminating in such a structure.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001719,,,,,,,BrendaTissueOBO,,BTO:0001719,,,,,,,,,,,,,,,,,,,claw,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_16359,"[""cholic acid""]","3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid|C24H40O5|(3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxycholan-24-oic acid|Cholsaeure|InChI=1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1|[H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]1([H])C[C@H](O)[C@]3(C)[C@]([H])(CC[C@@]3([H])[C@]1([H])[C@H](O)C2)[C@H](C)CCC(O)=O|BHQCQFFYRZLCQQ-OELDTZBJSA-N|3alpha,7alpha,12alpha-trihydroxy-5beta-cholanic acid|3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate|408.288|408.57140|0","A bile acid that is 5beta-cholan-24-oic acid bearing three alpha-hydroxy substituents at position 3, 7 and 12.",false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,Drug_Central:3096|Reaxys:2822009|PMID:22770225|LINCS:LSM-5541|HMDB:HMDB00619|MetaCyc:CHOLATE|CAS:81-25-4|Wikipedia:Cholic_Acid|PDBeChem:CHD|DrugBank:DB02659|Beilstein:2822009|KEGG:C00695|LIPID_MAPS_instance:LMST04010001,"A bile acid that is 5beta-cholan-24-oic acid bearing three alpha-hydroxy substituents at position 3, 7 and 12.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:20223|CHEBI:41494|CHEBI:23210|CHEBI:1694,,"CHOLIC ACID|Cholic acid|3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oic acid",,chebi_ontology,"3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid|C24H40O5|(3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxycholan-24-oic acid|Cholsaeure|InChI=1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1|[H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]1([H])C[C@H](O)[C@]3(C)[C@]([H])(CC[C@@]3([H])[C@]1([H])[C@H](O)C2)[C@H](C)CCC(O)=O|BHQCQFFYRZLCQQ-OELDTZBJSA-N|3alpha,7alpha,12alpha-trihydroxy-5beta-cholanic acid|3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate|408.288|408.57140|0",,,CHEBI:16359,,,,,,,,,,,,,,,,,,,,,,,CHEBI:16359,,,,,cholic acid,,CHEBI:16359,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3947,"[""adrenal gland hyperfunction""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3952,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3947,,,,SNOMEDCT_US_2016_03_01:111561007|SNOMEDCT_US_2016_03_01:275437005|UMLS_CUI:C0001622|SNOMEDCT_US_2016_03_01:190520005|SNOMEDCT_US_2016_03_01:47270006|MESH:D000308|NCI:C113208,hypercortisolism|hyperadrenalism|Adrenocortical hyperfunction,,disease_ontology,,DOID:3947,,,,,,,,,,,,,,,,,,,adrenal gland hyperfunction,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200342,"[""CDC42BPB gene""]",,"This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400265,,,,,,,,"This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200342,,,,,,,,,,,,,,,,9578,CDC42BPB,KIAA1124,,,,,,,,,,CDC42BPB gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200709,"[""OR8U8 gene""]",,"An olfactory receptor 8U8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7N1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 8U8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7N1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200709,,,,,,,,,,,,,,,,504189,OR8U8,,,,,,,,,,,OR8U8 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000242,"[""PHE114 in CSNK2A2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000242,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE114 in CSNK2A2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100185,"[""Potassium voltage-gated channel subfamily A member 6""]",,"A voltage-gated potassium channel subunit KCNA6 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P17658] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300537,,,,,,,,"A voltage-gated potassium channel subunit KCNA6 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P17658] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100185,,,,https://pharos.nih.gov/idg/targets/P17658,,,,,,,,,,,,,KCNA6,,,P17658,,,,,,,,Potassium voltage-gated channel subfamily A member 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001276,"[""pollen tube""]",,The slender tube formed by the pollen grain that penetrates an ovule and releases the male gametes.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The slender tube formed by the pollen grain that penetrates an ovule and releases the male gametes.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001276,,,,,,,BrendaTissueOBO,,BTO:0001276,,,,,,,,,,,,,,,,,,,pollen tube,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200581,"[""FN3K gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200581,,,,,,,,,,,,,,,,,,,,,,,,,,,,FN3K gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200342,"[""OR13C4 gene""]",,"An olfactory receptor 13C4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 13C4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200342,,,,,,,,,,,,,,,,138804,OR13C4,,,,,,,,,,,OR13C4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003499,"[""OVTOKO cell""]",,Human ovarian carcinoma cell line from clear cell adenocarcinoma.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001882,,,,,,,,Human ovarian carcinoma cell line from clear cell adenocarcinoma.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003499,,,,,,,BrendaTissueOBO,,BTO:0003499,,,,,,,,,,,,,,,,,,,OVTOKO cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002506,"[""enteric nervous system""]",,"Two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002506,,,,,,,BrendaTissueOBO,,BTO:0002506,,,,,,,,,,,,,,,,,,,enteric nervous system,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000314,"[""neuroepithelium""]",,"1: Simple columnar epithelium made up of cells specialized to serve as sensory cells for the reception of external stimuli, as the sensory cells of the cochlea, vestibule, nasal mucosa, and tongue. 2: The epithelium of the ectoderm, from which the central nervous system is developed.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000416,,,,,,,,"1: Simple columnar epithelium made up of cells specialized to serve as sensory cells for the reception of external stimuli, as the sensory cells of the cochlea, vestibule, nasal mucosa, and tongue. 2: The epithelium of the ectoderm, from which the central nervous system is developed.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000314,,,,,,,BrendaTissueOBO,sensory epithelium,BTO:0000314,,,,,,,,,,,,,,,,,,,neuroepithelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3116,"[""kidney benign neoplasm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_731|http://purl.obolibrary.org/obo/DOID_557,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3116,,,,NCI:C7514|UMLS_CUI:C1334323,renal and ureteral tumor,,disease_ontology,,DOID:3116,,,,,,,,,,,,,,,,,,,kidney benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100010,"[""Neuronal acetylcholine receptor subunit alpha-5""]",,"A neuronal acetylcholine receptor subunit alpha-5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30532] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300494,,,,,,,,"A neuronal acetylcholine receptor subunit alpha-5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30532] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100010,,,,https://pharos.nih.gov/idg/targets/P30532,,,,,,,,,,,,,CHRNA5,NACHRA5,,P30532,,,,,,,,Neuronal acetylcholine receptor subunit alpha-5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/PR_000000001,"[""protein""]",,An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA.,false,,,http://www.w3.org/2002/07/owl#Thing,,,,,,,,An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,protein,,,,PR:000000001,,,,,,,,,,,,,,,,,,,,,,,PR:000000001,,,Proteins descended from a common ancestor can be classified into families and superfamilies composed of products of evolutionarily-related genes. The domain architecture of a protein is described by the order of its constituent domains. Proteins with the same domains in the same order are defined as homeomorphic [PRO:WCB].,,protein,,PR:000000001,,http://purl.obolibrary.org/obo/pr.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000408,"[""epididymis""]",,A system of ductules emerging posteriorly from the testis that holds sperm during maturation and that forms a tangled mass before uniting into a single coiled duct which is continuous with the vas deferens.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003096,,,,,,,,A system of ductules emerging posteriorly from the testis that holds sperm during maturation and that forms a tangled mass before uniting into a single coiled duct which is continuous with the vas deferens.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000408,,,,,,,BrendaTissueOBO,Nebenhoden|Epididymus,BTO:0000408,,,,,,,,,,,,,,,,,,,epididymis,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100095,"[""Peripheral plasma membrane protein cask""]",,"peripheral plasma membrane protein cask (CASK)  with  no mutation  in a nonphosphorylated state|A peripheral plasma membrane protein CASK that is encoded in the genome of human. [PRO:CNx, Reactome:REACT_24832] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300143,,,,,,,,"peripheral plasma membrane protein cask (CASK)  with  no mutation  in a nonphosphorylated state|A peripheral plasma membrane protein CASK that is encoded in the genome of human. [PRO:CNx, Reactome:REACT_24832] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100095,,,,https://pharos.nih.gov/idg/targets/O14936,,,,,,,,,,,,,CASK,LIN2,,O14936,,,,,,,,Peripheral plasma membrane protein cask,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100246,"[""Latrophilin-3""]",,"A latrophilin-3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9HAR2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300039,,,,,,,,"A latrophilin-3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9HAR2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100246,,,,https://pharos.nih.gov/idg/targets/Q9HAR2,,,,,,,,,,,,,LPHN3,ADGRL3|KIAA0768|LEC3,,Q9HAR2,,,,,,,,Latrophilin-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200230,"[""KCNN3 gene""]",,"Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400437,,,,,,,,"Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200230,,,,,,,,,,,,,,,,3782,KCNN3,K3,,,,,,,,,,KCNN3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003097,"[""external male genital organ""]",,"The external genitalia in the male, comprising the penis, scrotum, and urethra.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The external genitalia in the male, comprising the penis, scrotum, and urethra.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003097,,,,,,,BrendaTissueOBO,organa genitalia masculina externa,BTO:0003097,,,,,,,,,,,,,,,,,,,external male genital organ,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200411,"[""PIP4K2C gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400323,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200411,,,,,,,,,,,,,,,,79837,PIP4K2C,PIP5K2C,,,,,,,,,,PIP4K2C gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001802,"[""rhabdomyosarcoma cell""]",,Malignant tumour (sarcoma) derived from striated muscle.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001207,,,,,,,,Malignant tumour (sarcoma) derived from striated muscle.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001802,,,,,,,BrendaTissueOBO,,BTO:0001802,,,,,,,,,,,,,,,,,,,rhabdomyosarcoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000081,"[""Ribosomal protein S19""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000081,,,,,,,,,,,,,,,,,,,,,,,,,,,,Ribosomal protein S19,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100502,"[""Olfactory receptor 1N1""]",,"An olfactory receptor 1N1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1N1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100502,,,,https://pharos.nih.gov/idg/targets/Q8NGS0,,,,,,,,,,,,,OR1N1,OR1N3,,Q8NGS0,,,,,,,,Olfactory receptor 1N1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200483,"[""OR1D5 gene""]",,"An olfactory receptor 1D5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58170] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1D5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58170] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200483,,,,,,,,,,,,,,,,8386,OR1D5,,,,,,,,,,,OR1D5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060101,"[""benign glioma""]",,A cell type benign neoplasm that has_material_basis_in glial cells.,false,,,http://purl.obolibrary.org/obo/DOID_0060084,,,,,,,,A cell type benign neoplasm that has_material_basis_in glial cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060101,lschriml,2011-07-19T01:27:04Z,,,,,disease_ontology,,DOID:0060101,,,,,,,,,,,,,,,,,,,benign glioma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060100,"[""musculoskeletal system cancer""]",,An organ system cancer located_in the muscular and skeletal organs and characterized by uncontrolled cellular proliferation of the musculoskeletal organs.,false,,,http://purl.obolibrary.org/obo/DOID_0050686|http://purl.obolibrary.org/obo/DOID_17,,,,,,,,An organ system cancer located_in the muscular and skeletal organs and characterized by uncontrolled cellular proliferation of the musculoskeletal organs.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060100,lschriml,2011-07-15T02:30:51Z,DOID:0060124,,skeletal system cancer,,disease_ontology,,DOID:0060100,,,,,,,,,,,,,,,,,,,musculoskeletal system cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060109,"[""vulvar benign neoplasm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060086,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060109,lschriml,2011-07-25T11:50:50Z,,,,,disease_ontology,,DOID:0060109,,,,,,,,,,,,,,,,,,,vulvar benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_33838,"[""nucleoside""]",C5H9O4R|a nucleoside|OC[C@H]1O[C@@H]([*])[C@H](O)[C@@H]1O|nucleosides,"
An N-glycosyl compound that has both a nucleobase, normally adenine, guanine, xanthine, thymine, cytosine or uracil, and either a ribose or deoxyribose as functional parents.
",false,,,http://purl.obolibrary.org/obo/CHEBI_23367,,,,,,,KEGG COMPOUND:C00801,"
An N-glycosyl compound that has both a nucleobase, normally adenine, guanine, xanthine, thymine, cytosine or uracil, and either a ribose or deoxyribose as functional parents.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:25611|CHEBI:13661|CHEBI:7647,,Nucleoside|nucleosides,,chebi_ontology,C5H9O4R|a nucleoside|OC[C@H]1O[C@@H]([*])[C@H](O)[C@@H]1O|nucleosides,,,CHEBI:33838,,,,,,,,,,,,,,,,,,,,,,,CHEBI:33838,,,,,Nucleoside|nucleoside,,CHEBI:33838,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200757,"[""GPRC5A gene""]",,"A retinoic acid-induced protein 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFJ5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400004,,,,,,,,"A retinoic acid-induced protein 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFJ5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200757,,,,,,,,,,,,,,,,9052,GPRC5A,GPCR5A|RAI3|RAIG1,,,,,,,,,,GPRC5A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100143,"[""Serine/threonine-protein kinase/endoribonuclease ire2""]",,"A serine/threonine-protein kinase/endoribonuclease IRE2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q76MJ5] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300154,,,,,,,,"A serine/threonine-protein kinase/endoribonuclease IRE2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q76MJ5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100143,,,,https://pharos.nih.gov/idg/targets/Q76MJ5,,,,,,,,,,,,,ERN2,IRE2,,Q76MJ5,,,,,,,,Serine/threonine-protein kinase/endoribonuclease ire2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2247,"[""spondylosis""]",,An bone structure disease that involves degeneration between vertebra located_in vertebral column.,false,,,http://purl.obolibrary.org/obo/DOID_0080010,,,,,,,,An bone structure disease that involves degeneration between vertebra located_in vertebral column.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2247,,,DOID:9949|DOID:8888|DOID:8708|DOID:8905|DOID:8709,SNOMEDCT_US_2016_03_01:268074002|SNOMEDCT_US_2016_03_01:202701004|ICD10CM:M47.9|MESH:D055009|ICD9CM:721.9|ICD10CM:M47|SNOMEDCT_US_2016_03_01:202704007|SNOMEDCT_US_2016_03_01:156628006|UMLS_CUI:C0038019|SNOMEDCT_US_2016_03_01:268075001|SNOMEDCT_US_2016_03_01:267973008|SNOMEDCT_US_2016_03_01:156622007|SNOMEDCT_US_2016_03_01:8847002,Lumbar spondylosis with myelopathy (disorder)|Spondylogenic compression of thoracic spinal cord|spondylosis with myelopathy|Spondylogenic compression of lumbar spinal cord|Spondylosis with myelopathy (disorder)|lumbosacral spondylosis without myelopathy|Thoracic or lumbar spondylosis with myelopathy,,disease_ontology,,DOID:2247,,,,,,,,,,,,,,,,,,,spondylosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4090,"[""agnosia""]",,"A communication disorder that is a loss of ability to recognize objects, persons, sounds, shapes, or smells while the specific sense is not defective nor is there any significant memory loss.",false,,,http://purl.obolibrary.org/obo/DOID_2033,,,,,,,,"A communication disorder that is a loss of ability to recognize objects, persons, sounds, shapes, or smells while the specific sense is not defective nor is there any significant memory loss.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4090,,,DOID:4019,ICD10CM:R48.2|SNOMEDCT_US_2016_03_01:42341009|SNOMEDCT_US_2016_03_01:6950007|UMLS_CUI:C0001816|SNOMEDCT_US_2016_03_01:250058008|MESH:D000377|SNOMEDCT_US_2016_03_01:206991001|NCI:C84542|SNOMEDCT_US_2016_03_01:158320000|SNOMEDCT_US_2016_03_01:206989009|SNOMEDCT_US_2016_03_01:158322008|SNOMEDCT_US_2016_03_01:192146008|ICD10CM:R48.1|SNOMEDCT_US_2016_03_01:271724003|MESH:D001072|UMLS_CUI:C0003635|SNOMEDCT_US_2016_03_01:68345001,Dyspraxia (finding)|Dyspraxia syndrome,,disease_ontology,,DOID:4090,,,,,,,,,,,,,,,,,,,agnosia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000107,"[""MET1140 in YSK4""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000107,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET1140 in YSK4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004796,"[""253J cell""]",,Human bladder transitional cell carcinoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002868,,,,,,,,Human bladder transitional cell carcinoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004796,mgr,2010-10-05T09:27:24Z,,,,,BrendaTissueOBO,,BTO:0004796,,,,,,,,,,,,,,,,,,,253J cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200188,"[""KCNB2 gene""]",,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400540,,,,,,,,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200188,,,,,,,,,,,,,,,,9312,KCNB2,,,,,,,,,,,KCNB2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003434,"[""choanomastigote""]",,"A term, in the series used to describe developmental stages of the parasitic flagellates, denoting the barleycorn form of the flagellate in the genus Crithidia characterised by a collarlike extension surrounding the anterior and through which the single flagellum emerges.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000092,,,,,,,,"A term, in the series used to describe developmental stages of the parasitic flagellates, denoting the barleycorn form of the flagellate in the genus Crithidia characterised by a collarlike extension surrounding the anterior and through which the single flagellum emerges.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003434,,,,,,,BrendaTissueOBO,choanoflagellate|collared flagellate ,BTO:0003434,,,,,,,,,,,,,,,,,,,choanomastigote,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100124,"[""Gamma-aminobutyric acid receptor subunit rho-3""]",,"A gamma-aminobutyric acid receptor subunit rho-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A8MPY1] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300523,,,,,,,,"A gamma-aminobutyric acid receptor subunit rho-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A8MPY1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100124,,,,https://pharos.nih.gov/idg/targets/A8MPY1,,,,,,,,,,,,,GABRR3,,,A8MPY1,,,,,,,,Gamma-aminobutyric acid receptor subunit rho-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001058,"[""phloem""]",,A complex tissue in the vascular system of higher plants that consists mainly of sieve tubes and elongated parenchyma cells usually with fibers and that functions in translocation and in support and storage.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A complex tissue in the vascular system of higher plants that consists mainly of sieve tubes and elongated parenchyma cells usually with fibers and that functions in translocation and in support and storage.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001058,,,,,,,BrendaTissueOBO,,BTO:0001058,,,,,,,,,,,,,,,,,,,phloem,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2352,"[""hemochromatosis""]",,A metal metabolism disorder characterized by the accumulation of iron in various organs of the body.,false,,,http://purl.obolibrary.org/obo/DOID_896,,,,,,,,A metal metabolism disorder characterized by the accumulation of iron in various organs of the body.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2352,,,,OMIM:604250|ORDO:139498|SNOMEDCT_US_2016_03_01:399187006|MESH:D006432|SNOMEDCT_US_2016_03_01:154751003|ICD10CM:E83.11|ORDO:79230|ICD10CM:E83.119|ORDO:225123|OMIM:231100|OMIM:613313|SNOMEDCT_US_2016_03_01:267504005|SNOMEDCT_US_2016_03_01:86781004|ORDO:139491|UMLS_CUI:C0018995|OMIM:602390|ICD10CM:E83.110|NCI:C84481|OMIM:235200|OMIM:606069|SNOMEDCT_US_2016_03_01:399144008,Haemochromatosis|iron storage disorder|diabetes bronze,,disease_ontology,,DOID:2352,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,hemochromatosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200328,"[""MKNK1 gene""]",,"This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400296,,,,,,,,"This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200328,,,,,,,,,,,,,,,,8569,MKNK1,MNK1,,,,,,,,,,MKNK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000539,"[""granulocyte""]",,"A polymorphonuclear white blood cell with granule-containingcytoplasm. In humans the granulocytes are also classified as polymorphonuclear leucocytes and are subdivided according to the staining properties of the granules into eosinophils, basophils and neutrophils, some invertebrate blood cells are also referred to, not very helpfully, as granulocytes.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000751,,,,,,,,"A polymorphonuclear white blood cell with granule-containingcytoplasm. In humans the granulocytes are also classified as polymorphonuclear leucocytes and are subdivided according to the staining properties of the granules into eosinophils, basophils and neutrophils, some invertebrate blood cells are also referred to, not very helpfully, as granulocytes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000539,,,,,,,BrendaTissueOBO,,BTO:0000539,,,,,,,,,,,,,,,,,,,granulocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300260,"[""CDK4 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300136,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300260,,,,,,,,,,,,,,,,,,,,,,,,,,,,CDK4 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001683,"[""adenohypophysis tumor cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001683,,,,,,,BrendaTissueOBO,anterior pituitary gland tumor cell|anterior pituitary tumor cell,BTO:0001683,,,,,,,,,,,,,,,,,,,adenohypophysis tumor cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000055,"[""LEU141 in RSK1(Kin.Dom.1-N-terminal)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000055,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU141 in RSK1(Kin.Dom.1-N-terminal),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200338,"[""TRPV6 gene""]",,"This gene encodes a member of a family of multipass membrane proteins that functions as calcium channels. The encoded protein contains N-terminal ankyrin repeats, which are required for channel assembly and regulation. This gene is situated next to a closely related gene for transient receptor potential cation channel subfamily V member 5 (TRPV5). This locus has experienced positive selection in non-African populations, resulting in several non-synonymous codon differences among individuals of different genetic backgrounds. [provided by RefSeq, Jul 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_01400595,,,,,,,,"This gene encodes a member of a family of multipass membrane proteins that functions as calcium channels. The encoded protein contains N-terminal ankyrin repeats, which are required for channel assembly and regulation. This gene is situated next to a closely related gene for transient receptor potential cation channel subfamily V member 5 (TRPV5). This locus has experienced positive selection in non-African populations, resulting in several non-synonymous codon differences among individuals of different genetic backgrounds. [provided by RefSeq, Jul 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200338,,,,,,,,,,,,,,,,55503,TRPV6,ECAC2,,,,,,,,,,TRPV6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100077,"[""Chloride transport protein 6""]",,"A chloride channel protein 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51797] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300400,,,,,,,,"A chloride channel protein 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51797] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100077,,,,https://pharos.nih.gov/idg/targets/P51797,,,,,,,,,,,,,CLCN6,KIAA0046,,P51797,,,,,,,,Chloride transport protein 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100021,"[""I317 in ABL1(F317I)-nonphosphorylated""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100021,,,,,,,,,,,,,,,,,,,,,,,,,,,,I317 in ABL1(F317I)-nonphosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200264,"[""MRGPRX4 gene""]",,"A mas-related G-protein coupled receptor X4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96LA9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400063,,,,,,,,"A mas-related G-protein coupled receptor X4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96LA9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200264,,,,,,,,,,,,,,,,117196,MRGPRX4,MRGX4|SNSR5|SNSR6,,,,,,,,,,MRGPRX4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400198,"[""NRBP family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400198,,,,,,,,,,,,,,,,,,,,,,,,,,,,NRBP family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200386,"[""OR51A7 gene""]",,"An olfactory receptor 51A7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH64] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 51A7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH64] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200386,,,,,,,,,,,,,,,,119687,OR51A7,,,,,,,,,,,OR51A7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12171,"[""radial neuropathy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1188,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12171,,,,MESH:D020425|UMLS_CUI:C0748226|SNOMEDCT_US_2016_03_01:16644004,Radial neuropathy (disorder),,disease_ontology,,DOID:12171,,,,,,,,,,,,,,,,,,,radial neuropathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12177,"[""common variable immunodeficiency""]",,A hypogammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells. Patients with common variable immunodeficiency have marked reduction in serum levels of both immunoglobulin G (IgG) and immunoglobulin A (IgA); about half of these patients also have reduced immunoglobulin M (IgM).,false,,,http://purl.obolibrary.org/obo/DOID_2583,,,,,,,,A hypogammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells. Patients with common variable immunodeficiency have marked reduction in serum levels of both immunoglobulin G (IgG) and immunoglobulin A (IgA); about half of these patients also have reduced immunoglobulin M (IgM).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12177,,,,OMIM:613493|OMIM:607594|SNOMEDCT_US_2016_03_01:23238000|ICD9CM:279.06|UMLS_CUI:C0009447|MESH:D017074|OMIM:613496|OMIM:615767|OMIM:615577|SNOMEDCT_US_2016_03_01:191010004|ICD10CM:D83.9|OMIM:614699|ICD10CM:D83|OMIM:613495|OMIM:240500|OMIM:614700|OMIM:613494|ORDO:1572,common variable agammaglobulinemia|acquired hypogammaglobulinemia|sporadic hypogammaglobulinemia|acquired agammaglobulinemia|CVID,,disease_ontology,,DOID:12177,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,common variable immunodeficiency,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12176,"[""goiter""]",,A thyroid gland disease that involves an abnormal enlargement of the thyroid gland.,false,,,http://purl.obolibrary.org/obo/DOID_50,,,,,,,,A thyroid gland disease that involves an abnormal enlargement of the thyroid gland.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12176,,,,SNOMEDCT_US_2016_03_01:190232008|SNOMEDCT_US_2016_03_01:3716002|ICD9CM:240.9|SNOMEDCT_US_2016_03_01:237568003|SNOMEDCT_US_2016_03_01:190235005|SNOMEDCT_US_2016_03_01:267370001|ICD10CM:E04.9|UMLS_CUI:C0018021|MESH:D006042|NCI:C26785,goitre,,disease_ontology,,DOID:12176,,,,,,,,,,,,,,,,,,,goiter,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_16670,"[""peptide""]",(C2H2NOR)nC2H3NOR|peptidos|Peptid|peptido|0,"Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc.|
Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc.
",false,,,http://purl.obolibrary.org/obo/CHEBI_23367,,,,,,,KEGG COMPOUND:C00012|KEGG:C00012,"Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc.|
Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:7990|CHEBI:25906|CHEBI:14753,,Peptide|peptides,,chebi_ontology,(C2H2NOR)nC2H3NOR|peptidos|Peptid|peptido|0,,,CHEBI:16670,,,,,,,,,,,,,,,,,,,,,,,CHEBI:16670,,,,,Peptide|peptide,,CHEBI:16670,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000259,"[""PHE275 in HIPK3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000259,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE275 in HIPK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_53,"[""pituitary gland disease""]",,An endocrine system disease that is located_in the pituitary gland.,false,,,http://purl.obolibrary.org/obo/DOID_28,,,,,,,,An endocrine system disease that is located_in the pituitary gland.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:53,,,DOID:8713|DOID:8714|DOID:2445,ICD9CM:253.1|UMLS_CUI:C0029493,pituitary disease,,disease_ontology,,DOID:53,,,,,,,,,,,,,,,,,,,pituitary gland disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_535,"[""sleep disorder""]",,A disease of mental health that involves disruption of sleep patterns.,false,,,http://purl.obolibrary.org/obo/DOID_150,,,,,,,,A disease of mental health that involves disruption of sleep patterns.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:535,,,DOID:9028,UMLS_CUI:C0154564|ICD9CM:307.4,Non-organic sleep disorder,,disease_ontology,,DOID:535,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,sleep disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_530,"[""eyelid disease""]",,An adnexa disease that is located_in the eyelid.,false,,,http://purl.obolibrary.org/obo/DOID_0050815,,,,,,,,An adnexa disease that is located_in the eyelid.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:530,,,,SNOMEDCT_US_2016_03_01:60113004|SNOMEDCT_US_2016_03_01:155180006|NCI:C26768|UMLS_CUI:C0015423|ICD10CM:H02.9|ICD9CM:374.9|SNOMEDCT_US_2016_03_01:267737009|MESH:D005141|SNOMEDCT_US_2016_03_01:193970000,,,disease_ontology,,DOID:530,,,,,,,,,,,,,,,,,,,eyelid disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_533,"[""thymus gland disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_75,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:533,,,DOID:11024,ICD9CM:254|SNOMEDCT_US_2016_03_01:190500009|SNOMEDCT_US_2016_03_01:20673009|UMLS_CUI:C0154199|ICD10CM:E32.9|ICD9CM:254.9|ICD10CM:E32|SNOMEDCT_US_2016_03_01:154703006|NCI:C26962|SNOMEDCT_US_2016_03_01:267482009,disease of thymus gland,,disease_ontology,,DOID:533,,,,,,,,,,,,,,,,,,,thymus gland disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_539,"[""ophthalmoplegia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1279,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:539,,,DOID:10868,UMLS_CUI:C0029089|UMLS_CUI:C0155338|SNOMEDCT_US_2016_03_01:78097002|SNOMEDCT_US_2016_03_01:155196009|SNOMEDCT_US_2016_03_01:16110005|NCI:C79697|SNOMEDCT_US_2016_03_01:267745004|ICD9CM:378.56|MESH:D009886,oculomotor paralysis|Total ophthalmoplegia,,disease_ontology,,DOID:539,,,,,,,,,,,,,,,,,,,ophthalmoplegia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000088,"[""CCL21""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000088,,,,,,,,,,,,,,,,,,,,,,,,,,,,CCL21,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100523,"[""Tgf-beta receptor type-1""]",,"TGF-beta receptor type-1 (TGFBR1)  with  no mutation  in a nonphosphorylated state|A TGF-beta receptor type-1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P36897] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300246,,,,,,,,"TGF-beta receptor type-1 (TGFBR1)  with  no mutation  in a nonphosphorylated state|A TGF-beta receptor type-1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P36897] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100523,,,,https://pharos.nih.gov/idg/targets/P36897,,,,,,,,,,,,,TGFBR1,ALK5|SKR4,,P36897,,,,,,,,Tgf-beta receptor type-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217528,"[""NR0B1 gene""]",,"This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_00217459,,,,,,,,"This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217528,,,,,,,,,,,,,,,,190,NR0B1,AHC|DAX1,,,,,,,,,,NR0B1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001175,"[""retina""]",,"The sensory membrane that lines the eye, is composed of several layers including one containing the rods and cones, and functions as the immediate instrument of vision by receiving the image formed by the lens and converting it into chemical and nervous signals which reach the brain by way of the optic nerve.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The sensory membrane that lines the eye, is composed of several layers including one containing the rods and cones, and functions as the immediate instrument of vision by receiving the image formed by the lens and converting it into chemical and nervous signals which reach the brain by way of the optic nerve.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001175,,,,,,,BrendaTissueOBO,Netzhaut,BTO:0001175,,,,,,,,,,,,,,,,,,,retina,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000049,"[""BLK kinase domain""]",,Tyrosine-protein kinase BLK; B lymphoid tyrosine kinase; BLK; MGC10442,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Tyrosine-protein kinase BLK; B lymphoid tyrosine kinase; BLK; MGC10442,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000049,,,,,,,,,,,,,,,,,,,200049,,,,,,,,,BLK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_18397,"[""Beta-phenylethylamine""]","beta-Phenylaethylamin (german)|2-phenylethanamine|PEA|NCCc1ccccc1|beta Phenethylamine|b-Aminoethylbenzene|(2-Aminoethyl)polystyrene|beta-Phenylaethylamin [german]|Benzeneethanamine hydrochloride|b-Phenylaethylamin (german)|beta-Phenylaethylamin|b-Phenethylamine|1-Phenyl-2-amino-athan [German]|C8H11N|benzeneethanamine|2-Amino-fenylethan [Czech]|Omega-phenylethylamine|1utm|1-Phenyl-2-amino-athan|b-Phenylaethylamin|beta-aminoethylbenzene|Phenethylamine|2-Phenylethylamine (ACD/Name 4.0)|1-Phenethylamine|1-Amino-2-phenylethane|2-Fenylethylamin [Czech]|InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2|beta-Phenylethylamine|1-Phenyl-2-aminoethane|1-Phenyl-2-amino-athan (GERMAN)|b-Phenylethylamine|2-Phenylethanamine (ACD/Name 4.0)|2-Phenethylamine|1uto|2-Amino-fenylethan|2-Amino-1-phenylethane|Phenethylamine hydrochloride|Phenylethylamine|2-Phenyl-Ethanamine|2-Fenylethylamin|1tnj|BHHGXPLMPWCGHP-UHFFFAOYSA-N|2-phenylethan-1-amine|beta-phenethylamine|Polystyrene A-NH2|(2-Aminoethyl)benzene","
A phenylethylamine having the phenyl substituent at the 2-position.
",false,,,http://purl.obolibrary.org/obo/CHEBI_32952,,,,,,,CiteXplore:23225177|HMDB:HMDB12275|DrugBank:DB04325|Wikipedia:2-phenylethylamine|CiteXplore:12205654|Gmelin:50120|CiteXplore:20390105|Reaxys:507488|KNApSAcK:C00001426|CiteXplore:7906896|MetaCyc:PHENYLETHYLAMINE|ChemIDplus:64-04-0|PDBeChem:PEA|ECMDB:ECMDB02654|KEGG COMPOUND:C05332|CiteXplore:7918350|KEGG COMPOUND:64-04-0|CiteXplore:23564683|CiteXplore:21690383|CiteXplore:21191624|Beilstein:507488|CiteXplore:7360842|NIST Chemistry WebBook:64-04-0,"
A phenylethylamine having the phenyl substituent at the 2-position.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:8063|CHEBI:14782|CHEBI:25965,,2-phenylethanamine|2-Phenylethylamine,,chebi_ontology,"beta-Phenylaethylamin (german)|2-phenylethanamine|PEA|NCCc1ccccc1|beta Phenethylamine|b-Aminoethylbenzene|(2-Aminoethyl)polystyrene|beta-Phenylaethylamin [german]|Benzeneethanamine hydrochloride|b-Phenylaethylamin (german)|beta-Phenylaethylamin|b-Phenethylamine|1-Phenyl-2-amino-athan [German]|C8H11N|benzeneethanamine|2-Amino-fenylethan [Czech]|Omega-phenylethylamine|1utm|1-Phenyl-2-amino-athan|b-Phenylaethylamin|beta-aminoethylbenzene|Phenethylamine|2-Phenylethylamine (ACD/Name 4.0)|1-Phenethylamine|1-Amino-2-phenylethane|2-Fenylethylamin [Czech]|InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2|beta-Phenylethylamine|1-Phenyl-2-aminoethane|1-Phenyl-2-amino-athan (GERMAN)|b-Phenylethylamine|2-Phenylethanamine (ACD/Name 4.0)|2-Phenethylamine|1uto|2-Amino-fenylethan|2-Amino-1-phenylethane|Phenethylamine hydrochloride|Phenylethylamine|2-Phenyl-Ethanamine|2-Fenylethylamin|1tnj|BHHGXPLMPWCGHP-UHFFFAOYSA-N|2-phenylethan-1-amine|beta-phenethylamine|Polystyrene A-NH2|(2-Aminoethyl)benzene",,,CHEBI:18397,,,,,,,,,,,,,,,,,,,,,,,CHEBI:18397,,,,,2-phenylethylamine|Beta-phenylethylamine,,CHEBI:18397,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100062,"[""C-C chemokine receptor-like 2""]",,"A C-C chemokine receptor-like 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00421] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300095,,,,,,,,"A C-C chemokine receptor-like 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00421] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100062,,,,https://pharos.nih.gov/idg/targets/O00421,,,,,,,,,,,,,CCRL2,CCR11|CCR6|CKRX|CRAM|HCR,,O00421,,,,,,,,C-C chemokine receptor-like 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391002,"[""ATP-dependent PFK group I subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391016,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391002,,,,,,,,,,,,,,,,,,,,,,,,,,,,ATP-dependent PFK group I subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200099,"[""DAPK2 gene""]",,"This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis.  It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400146,,,,,,,,"This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis.  It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200099,,,,,,,,,,,,,,,,23604,DAPK2,,,,,,,,,,,DAPK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4551,"[""anus neoplasm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4610,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4551,,,,NCI:C2877|UMLS_CUI:C0003463|MESH:D001005|SNOMEDCT_US_2016_03_01:126849006,neoplasm of anus|anal neoplasm|anal tumors,,disease_ontology,,DOID:4551,,,,,,,,,,,,,,,,,,,anus neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000123,"[""MET138 in STK39""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000123,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET138 in STK39,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003585,"[""SR cell""]",,"Human large cell immunoblastic lymphoma cell line, derived from a pleural effusion of a 11 years old caucasian boy.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002904,,,,,,,,"Human large cell immunoblastic lymphoma cell line, derived from a pleural effusion of a 11 years old caucasian boy.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003585,,,,,,,BrendaTissueOBO,SR NHL cell,BTO:0003585,,,,,,,,,,,,,,,,,,,SR cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100650,"[""Olfactory receptor 6a2""]",,"An olfactory receptor 6A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95222] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95222] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100650,,,,https://pharos.nih.gov/idg/targets/O95222,,,,,,,,,,,,,OR6A2,OR6A1|OR6A2P,,O95222,,,,,,,,Olfactory receptor 6a2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200276,"[""NPBWR1 gene""]",,"A neuropeptides B/W receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48145] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400068,,,,,,,,"A neuropeptides B/W receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48145] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200276,,,,,,,,,,,,,,,,2831,NPBWR1,GPR7,,,,,,,,,,NPBWR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100362,"[""Olfactory receptor 2AG1""]",,"An olfactory receptor 2AG1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H205] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2AG1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H205] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100362,,,,https://pharos.nih.gov/idg/targets/Q9H205,,,,,,,,,,,,,OR2AG1,OR2AG3,,Q9H205,,,,,,,,Olfactory receptor 2AG1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005065,"[""Swiss-3T3 cell""]",,An immortal line of fibroblast like cells established from whole trypsinised embryos of Swiss mice (not an inbred stock) under conditions that favour establishment of cells with low saturation density in culture.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001958,,,,,,,,An immortal line of fibroblast like cells established from whole trypsinised embryos of Swiss mice (not an inbred stock) under conditions that favour establishment of cells with low saturation density in culture.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005065,XPMUser,2011-03-07T02:01:59Z,,,,,BrendaTissueOBO,Swiss 3T3 cell|Swiss/3T3 cell|Swiss3T3 cell,BTO:0005065,,,,,,,,,,,,,,,,,,,Swiss-3T3 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1702,"[""ichthyosis vulgaris""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1702,,,,SNOMEDCT_US_2016_03_01:254157005|MESH:D016112|SNOMEDCT_US_2016_03_01:205551004|UMLS_CUI:C0079584|NCI:C84778|SNOMEDCT_US_2016_03_01:20512000|ICD10CM:Q80.0|OMIM:146700,Dominant congenital ichthyosiform erythroderma (disorder),,disease_ontology,,DOID:1702,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,ichthyosis vulgaris,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5434,"[""scrapie""]",,,false,,,http://purl.obolibrary.org/obo/DOID_649,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5434,,,,SNOMEDCT_US_2016_03_01:35103004|MESH:D012608|UMLS_CUI:C0036457,,,disease_ontology,,DOID:5434,,,,,,,,,,,,,,,,,,,scrapie,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100590,"[""Inositol hexakisphosphate kinase 2""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100590,,,,,,,,,,,,,,,,,IP6K2,,,Q9UHH9,,,,,,,,Inositol hexakisphosphate kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300243,"[""VRK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300112,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300243,,,,,,,,,,,,,,,,,,,,,,,,,,,,VRK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001890,"[""RKO cell""]",,Human colon carcinoma cell line. RKO is a poorly differentiated colon carcinoma cell line developed by Michael Brattain. The RKO cell line is the parental cell line (isogenic) of RKO-E6 and RKO-A545-1.,false,,,http://purl.obolibrary.org/obo/BTO_0000797|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human colon carcinoma cell line. RKO is a poorly differentiated colon carcinoma cell line developed by Michael Brattain. The RKO cell line is the parental cell line (isogenic) of RKO-E6 and RKO-A545-1.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001890,,,,,,,BrendaTissueOBO,,BTO:0001890,,,,,,,,,,,,,,,,,,,RKO cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117511,"[""Estrogen receptor""]",,"An estrogen receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P03372] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117472,,,,,,,,"An estrogen receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P03372] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117511,,,,https://pharos.nih.gov/idg/targets/P03372,,,,,,,,,,,,,ESR1,NR3A1,,P03372,,,,,,,,Estrogen receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200171,"[""KCNAB3 gene""]",,"This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. The encoded protein is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. The encoded protein forms a heterodimer with the potassium voltage-gated channel, shaker-related subfamily, member 5 gene product and regulates the activity of the alpha subunit. [provided by RefSeq, May 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400356,,,,,,,,"This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. The encoded protein is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. The encoded protein forms a heterodimer with the potassium voltage-gated channel, shaker-related subfamily, member 5 gene product and regulates the activity of the alpha subunit. [provided by RefSeq, May 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200171,,,,,,,,,,,,,,,,9196,KCNAB3,KCNA3B,,,,,,,,,,KCNAB3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491048,"[""PFKFB2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400325,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491048,,,,,,,,,,,,,,,,,PFKFB2,,,,,,,,,,,PFKFB2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13189,"[""gout""]",,An arthritis that has_material_basis_in uric acid crystal deposits located_in joint.,false,,,http://purl.obolibrary.org/obo/DOID_848,,,,,,,,An arthritis that has_material_basis_in uric acid crystal deposits located_in joint.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13189,,,DOID:14144,ICD10CM:M10|SNOMEDCT_US_2016_03_01:90560007|EFO:0004274|SNOMEDCT_US_2016_03_01:154746009|MESH:D006073|SNOMEDCT_US_2016_03_01:190844004|SNOMEDCT_US_2016_03_01:190828008|SNOMEDCT_US_2016_03_01:154745008|UMLS_CUI:C0003868|ICD9CM:274.0|ICD9CM:274.9|ICD9CM:274.00|NCI:C34650|ICD9CM:274|ICD10CM:M10.9|UMLS_CUI:C0018099|SNOMEDCT_US_2016_03_01:48440001|SNOMEDCT_US_2016_03_01:201661008|SNOMEDCT_US_2016_03_01:147966005|SNOMEDCT_US_2016_03_01:170733007|MESH:D015210|SNOMEDCT_US_2016_03_01:201672003|SNOMEDCT_US_2016_03_01:201662001|SNOMEDCT_US_2016_03_01:190827003,Articular gout|Gouty arthropathy|gouty arthritis,,disease_ontology,,DOID:13189,,,,,,,,,,,,,,,,,,,gout,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200422,"[""PIK3CA gene""]",,"Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03491009,,,,,,,,"Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200422,,,,,,,,,,,,,,,,5290,PIK3CA,,,,,,,,,,,PIK3CA gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100104,"[""Frizzled-2""]",,"A frizzled-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14332] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300043,,,,,,,,"A frizzled-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14332] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100104,,,,https://pharos.nih.gov/idg/targets/Q14332,,,,,,,,,,,,,FZD2,,,Q14332,,,,,,,,Frizzled-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200359,"[""OR2A14 gene""]",,"An olfactory receptor 2A14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R47] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2A14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R47] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200359,,,,,,,,,,,,,,,,135941,OR2A14,OR2A14P|OR2A6,,,,,,,,,,OR2A14 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200780,"[""TAS2R19 gene""]",,"A taste receptor type 2 member 19 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59542] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400014,,,,,,,,"A taste receptor type 2 member 19 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59542] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200780,,,,,,,,,,,,,,,,259294,TAS2R19,TAS2R23|TAS2R48,,,,,,,,,,TAS2R19 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117506,"[""Nuclear receptor subfamily 2 group e member 1""]",,"A nuclear receptor subfamily 2 group E member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y466] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117470,,,,,,,,"A nuclear receptor subfamily 2 group E member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y466] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117506,,,,https://pharos.nih.gov/idg/targets/Q9Y466,,,,,,,,,,,,,NR2E1,,,Q9Y466,,,,,,,,Nuclear receptor subfamily 2 group e member 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200605,"[""NADK gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200605,,,,,,,,,,,,,,,,,,,,,,,,,,,,NADK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200270,"[""P2RX7 gene""]",,"The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400364,,,,,,,,"The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200270,,,,,,,,,,,,,,,,5027,P2RX7,,,,,,,,,,,P2RX7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200186,"[""INSR gene""]",,"After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400163,,,,,,,,"After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200186,,,,,,,,,,,,,,,,3643,INSR,,,,,,,,,,,INSR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200329,"[""TRPM4 gene""]",,"The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400586,,,,,,,,"The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200329,,,,,,,,,,,,,,,,54795,TRPM4,LTRPC4,,,,,,,,,,TRPM4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002380,"[""gastric adenocarcinoma cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0000167|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000787,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002380,,,,,,,BrendaTissueOBO,,BTO:0002380,,,,,,,,,,,,,,,,,,,gastric adenocarcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100623,"[""Olfactory receptor 5F1""]",,"An olfactory receptor 5F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95221] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95221] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100623,,,,https://pharos.nih.gov/idg/targets/O95221,,,,,,,,,,,,,OR5F1,,,O95221,,,,,,,,Olfactory receptor 5F1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200132,"[""GPR113 gene""]",,"A G-protein coupled receptor 113 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,"A G-protein coupled receptor 113 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200132,,,,,,,,,,,,,,,,165082,GPR113,PGR23,,,,,,,,,,GPR113 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300438,"[""KCNMB/KCNMB1 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300358,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300438,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNMB/KCNMB1 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000084,"[""LEU92 in SNRK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000084,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU92 in SNRK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100005,"[""5-hydroxytryptamine receptor 3e""]",,"A 5-hydroxytryptamine receptor 3E that is encoded in the genome of human. [PRO:DNx, UniProtKB:A5X5Y0] ",false,,,http://www.drugtargetontology.org/dto/DTO_01309332,,,,,,,,"A 5-hydroxytryptamine receptor 3E that is encoded in the genome of human. [PRO:DNx, UniProtKB:A5X5Y0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100005,,,,https://pharos.nih.gov/idg/targets/A5X5Y0,,,,,,,,,,,,,HTR3E,,,A5X5Y0,,,,,,,,5-hydroxytryptamine receptor 3e,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100135,"[""Ephrin type-b receptor 2""]",,"ephrin type-b receptor 2 (EPHB2)  with  no mutation  in a nonphosphorylated state|An ephrin type-B receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P29323] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300153,,,,,,,,"ephrin type-b receptor 2 (EPHB2)  with  no mutation  in a nonphosphorylated state|An ephrin type-B receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P29323] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100135,,,,https://pharos.nih.gov/idg/targets/P29323,,,,,,,,,,,,,EPHB2,DRT|EPHT3|EPTH3|ERK|HEK5|TYRO5,,P29323,,,,,,,,Ephrin type-b receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005525,"[""plant primordium""]",,A cell or organ in its initial stage of development.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A cell or organ in its initial stage of development.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005525,Marion,2013-11-06T10:48:14Z,,,,,BrendaTissueOBO,,BTO:0005525,,,,,,,,,,,,,,,,,,,plant primordium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000128,"[""Dynorphin A-(1-13)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000128,,,,,,,,,,,,,,,,,,,,,,,,,,,,Dynorphin A-(1-13),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491038,"[""SNRK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400116,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491038,,,,,,,,,,,,,,,,,,,,,,,,,,,,SNRK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200028,"[""ADRA1B gene""]",,"An alpha-1B adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35368] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400093,,,,,,,,"An alpha-1B adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35368] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200028,,,,,,,,,,,,,,,,147,ADRA1B,,,,,,,,,,,ADRA1B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_33569,"[""noradrenaline""]","NCC(O)c1ccc(O)c(O)c1|C8H11NO3|norepinephrine|
InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2
|SFLSHLFXELFNJZ-UHFFFAOYSA-N|noradrenalina","
A catecholamine in which C-1 of the aminoethyl side-chain is hydroxy-substituted.
",false,,,http://purl.obolibrary.org/obo/CHEBI_32952,,,,,,,Gmelin:863925|Beilstein:2210994|ChemIDplus:138-65-8|NIST Chemistry WebBook:138-65-8,"
A catecholamine in which C-1 of the aminoethyl side-chain is hydroxy-substituted.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,"4-(2-amino-1-hydroxyethyl)benzene-1,2-diol",,chebi_ontology,"NCC(O)c1ccc(O)c(O)c1|C8H11NO3|norepinephrine|
InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2
|SFLSHLFXELFNJZ-UHFFFAOYSA-N|noradrenalina",,,CHEBI:33569,,,,,,,,,,,,,,,,,,,,,,,CHEBI:33569,,,,,noradrenaline|Noradrenaline,,CHEBI:33569,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000050,"[""BMPR1A kinase domain""]",,"Bone morphogenetic protein receptor, type IA; 10q23del; ACVRLK3; ALK3; BMPR1A; CD292; SKR5",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Bone morphogenetic protein receptor, type IA; 10q23del; ACVRLK3; ALK3; BMPR1A; CD292; SKR5",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000050,,,,,,,,,,,,,,,,,,,200050,,,,,,,,,BMPR1A kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300261,"[""CDK5 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300136,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300261,,,,,,,,,,,,,,,,,,,,,,,,,,,,CDK5 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100124,"[""Epidermal growth factor receptor""]",,"epidermal growth factor receptor (EGFR(L747-E749del, A750P))  with  mutation L747-E749del and P750 in EGFR(L747-E749del, A750P) in a nonphosphorylated state|epidermal growth factor receptor (EGFR(L861Q))  with  mutation Q861 in EGFR(L861Q) in a nonphosphorylated state|epidermal growth factor receptor (EGFR(S752-I759del))  with  mutation S752-I759del in EGFR(S752-I759del) in a nonphosphorylated state|epidermal growth factor receptor (EGFR(G719C))  with  mutation C719 in EGFR(G719C) in a nonphosphorylated state|epidermal growth factor receptor (EGFR(E746-A750del))  with  mutation A746-A750del in EGFR(E746-A750del) in a nonphosphorylated state|An epidermal growth factor receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00533] |epidermal growth factor receptor (EGFR(L747-T751del,Sins))  with  mutation T747-T751del and Silenced in EGFR(L747-T751del,Sins) in a nonphosphorylated state|epidermal growth factor receptor (EGFR(L747-S752del, P753S))  with  mutation L747-S752del and S753 in EGFR(L747-S752del, P753S) in a nonphosphorylated state|epidermal growth factor receptor (EGFR(G719S))  with  mutation S719 in EGFR(G719S) in a nonphosphorylated state|epidermal growth factor receptor (EGFR(T790M))  with  mutation M790 in EGFR(T790M) in a nonphosphorylated state|epidermal growth factor receptor (EGFR(L858R))  with  mutation R858 in EGFR(L858R) in a nonphosphorylated state|epidermal growth factor receptor (EGFR(L858R,T790M))  with  mutation R858 and M790 in EGFR(L858R,T790M) in a nonphosphorylated state|epidermal growth factor receptor (EGFR)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300152,,,,,,,,"epidermal growth factor receptor (EGFR(L747-E749del, A750P))  with  mutation L747-E749del and P750 in EGFR(L747-E749del, A750P) in a nonphosphorylated state|epidermal growth factor receptor (EGFR(L861Q))  with  mutation Q861 in EGFR(L861Q) in a nonphosphorylated state|epidermal growth factor receptor (EGFR(S752-I759del))  with  mutation S752-I759del in EGFR(S752-I759del) in a nonphosphorylated state|epidermal growth factor receptor (EGFR(G719C))  with  mutation C719 in EGFR(G719C) in a nonphosphorylated state|epidermal growth factor receptor (EGFR(E746-A750del))  with  mutation A746-A750del in EGFR(E746-A750del) in a nonphosphorylated state|An epidermal growth factor receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00533] |epidermal growth factor receptor (EGFR(L747-T751del,Sins))  with  mutation T747-T751del and Silenced in EGFR(L747-T751del,Sins) in a nonphosphorylated state|epidermal growth factor receptor (EGFR(L747-S752del, P753S))  with  mutation L747-S752del and S753 in EGFR(L747-S752del, P753S) in a nonphosphorylated state|epidermal growth factor receptor (EGFR(G719S))  with  mutation S719 in EGFR(G719S) in a nonphosphorylated state|epidermal growth factor receptor (EGFR(T790M))  with  mutation M790 in EGFR(T790M) in a nonphosphorylated state|epidermal growth factor receptor (EGFR(L858R))  with  mutation R858 in EGFR(L858R) in a nonphosphorylated state|epidermal growth factor receptor (EGFR(L858R,T790M))  with  mutation R858 and M790 in EGFR(L858R,T790M) in a nonphosphorylated state|epidermal growth factor receptor (EGFR)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100124,,,,https://pharos.nih.gov/idg/targets/P00533,,,,,,,,,,,,,EGFR,ERBB|ERBB1|HER1,,P00533,,,,,,,,Epidermal growth factor receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001909,"[""N1E-115 cell""]",,"Mus musculus (mouse) brain; neuroblast; neuroblastoma cell line. The N1E-115 cell line was established in 1971 by T. Amano, E. Richelson, and M. Nirenberg by cloning the C-1300 spontaneous mouse neuroblastoma tumor, C-1300.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000932,,,,,,,,"Mus musculus (mouse) brain; neuroblast; neuroblastoma cell line. The N1E-115 cell line was established in 1971 by T. Amano, E. Richelson, and M. Nirenberg by cloning the C-1300 spontaneous mouse neuroblastoma tumor, C-1300.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001909,,,,,,,BrendaTissueOBO,NIE-115 cell,BTO:0001909,,,,,,,,,,,,,,,,,,,N1E-115 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BFO_0000023,"[""role""]",,,false,,,http://www.w3.org/2002/07/owl#Thing,,,Role,role,,,,,,,,,,"BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals –  professor, sergeant, nurse – only during certain phases in their lives.",,"b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001])","the role of a stone in marking a property boundary|the priest role|the student role|the role of subject in a clinical trial|the role of a boundary to demarcate two neighboring administrative territories|John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married.|the role of a building in serving as a military target",,,,,(forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001] ,,,,,,,,,,,,,,,,,,,,,,,,,,,,BFO:0000023,,,,,,,,,,,,,,,,,,,,,,,,,,,http://purl.obolibrary.org/obo/bfo.owl,role,,,,http://purl.obolibrary.org/obo/bfo.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050096,"[""tinea barbae""]",,"A dermatophytosis that results_in fungal infection which effects horny layer of epidermis of the bearded areas located_in face or located_in neck, has_material_basis_in Trichophyton mentagrophytes or has_material_basis_in Trichophyton verrucosum, which also effects hair, and effects nail and has_symptom inflammatory kerion-like plaques, and results_in_formation_of noninflammatory superficial perifollicular pustules.",false,,,http://purl.obolibrary.org/obo/DOID_8913,,,,,,,,"A dermatophytosis that results_in fungal infection which effects horny layer of epidermis of the bearded areas located_in face or located_in neck, has_material_basis_in Trichophyton mentagrophytes or has_material_basis_in Trichophyton verrucosum, which also effects hair, and effects nail and has_symptom inflammatory kerion-like plaques, and results_in_formation_of noninflammatory superficial perifollicular pustules.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050096,,,,,dermatophytosis of beard,,disease_ontology,,DOID:0050096,,,,,,,,,,,,,,,,,,,tinea barbae,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300428,"[""KCNJ1 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300428,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ1 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005043,"[""M1 melanoma cell""]",,Human melanoma cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0000849|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human melanoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005043,XPMUser,2011-03-05T11:45:26Z,,,,,BrendaTissueOBO,M1 cell,BTO:0005043,,,,,,,,,,,,,,,,,,,M1 melanoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8466,"[""retinal degeneration""]",,A retinal disease that is characterized by deterioration of the retina caused by the progressive and eventual death of the cells of the retina.,false,,,http://purl.obolibrary.org/obo/DOID_5679,,,,,,,,A retinal disease that is characterized by deterioration of the retina caused by the progressive and eventual death of the cells of the retina.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8466,,,,MESH:D012162|NCI:C34979|SNOMEDCT_US_2016_03_01:95695004|UMLS_CUI:C0035304,degeneration of retina|RETINA degeneration,,disease_ontology,,DOID:8466,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,retinal degeneration,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400491,"[""Alpha-2/CHRNA2 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400491,,,,,,,,,,,,,,,,,,,,,,,,,,,,Alpha-2/CHRNA2 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200386,"[""PAK3 gene""]",,"PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400303,,,,,,,,"PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200386,,,,,,,,,,,,,,,,5063,PAK3,OPHN3,,,,,,,,,,PAK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200661,"[""OR6K2 gene""]",,"An olfactory receptor 6K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200661,,,,,,,,,,,,,,,,81448,OR6K2,,,,,,,,,,,OR6K2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100205,"[""Camp-dependent protein kinase catalytic subunit beta""]",,"A cAMP-dependent protein kinase catalytic subunit beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P22694] |camp-dependent protein kinase catalytic subunit beta (PKAC-beta)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300169,,,,,,,,"A cAMP-dependent protein kinase catalytic subunit beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P22694] |camp-dependent protein kinase catalytic subunit beta (PKAC-beta)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100205,,,,https://pharos.nih.gov/idg/targets/P22694,,,,,,,,,,,,,PRKACB,,,P22694,,,,,,,,Camp-dependent protein kinase catalytic subunit beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001538,"[""COS-1 cell""]",,African green monkey kidney cell line; established from CV-1 Simian cells (cercopithecus aethiops) which were transformed by an origin-defective mutant of SV-40; cells are host cells for the propagation of pure populations of recombinant SV virus.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0004055,,,,,,,,African green monkey kidney cell line; established from CV-1 Simian cells (cercopithecus aethiops) which were transformed by an origin-defective mutant of SV-40; cells are host cells for the propagation of pure populations of recombinant SV virus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001538,,,,,,,BrendaTissueOBO,COS1 cell,BTO:0001538,,,,,,,,,,,,,,,,,,,COS-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100004,"[""5-hydroxytryptamine receptor 1E""]",,"A 5-hydroxytryptamine receptor 1E that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28566] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302001,,,,,,,,"A 5-hydroxytryptamine receptor 1E that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28566] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100004,,,,https://pharos.nih.gov/idg/targets/P28566,,,,,,,,,,,,,HTR1E,,,P28566,,,,,,,,5-hydroxytryptamine receptor 1E,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000410,"[""SIK3 kinase domain""]",,Serine/threonine-protein kinase SIK3; SIK family kinase 3; FLJ12240; KIAA0999; L19; QSK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase SIK3; SIK family kinase 3; FLJ12240; KIAA0999; L19; QSK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000410,,,,,,,,,,,,,,,,,,,200368,,,,,,,,,SIK3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000042,"[""animal""]",,"Any of a kingdom (Animalia) of living things including many-celled organisms and often many of the single-celled ones (as protozoans) that typically differ from plants in having cells without cellulose walls, in lacking chlorophyll and the capacity for photosynthesis, in requiring more complex food materials (as proteins), in being organized to a greater degree of complexity, and in having the capacity for spontaneous movement and rapid motor responses to stimulation.",false,,,http://purl.obolibrary.org/obo/BTO_0000000|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Any of a kingdom (Animalia) of living things including many-celled organisms and often many of the single-celled ones (as protozoans) that typically differ from plants in having cells without cellulose walls, in lacking chlorophyll and the capacity for photosynthesis, in requiring more complex food materials (as proteins), in being organized to a greater degree of complexity, and in having the capacity for spontaneous movement and rapid motor responses to stimulation.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000042,,,,,,,BrendaTissueOBO,Tier|metazoa|animalia,BTO:0000042,,,,,,,,,,,,,,,,,,,animal,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100062,"[""Voltage-dependent calcium channel gamma-8 subunit""]",,"A voltage-dependent calcium channel gamma-8 subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WXS5] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300336,,,,,,,,"A voltage-dependent calcium channel gamma-8 subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WXS5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100062,,,,https://pharos.nih.gov/idg/targets/Q8WXS5,,,,,,,,,,,,,CACNG8,CACNG6,,Q8WXS5,,,,,,,,Voltage-dependent calcium channel gamma-8 subunit,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200774,"[""SSTR5 gene""]",,"A somatostatin receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35346] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A somatostatin receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35346] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200774,,,,,,,,,,,,,,,,6755,SSTR5,,,,,,,,,,,SSTR5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001264,"[""spinal ganglion""]",,A ganglion on the dorsal root of each spinal nerve that is one of a series of ganglia lodging cell bodies of sensory neurons.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001123,,,,,,,,A ganglion on the dorsal root of each spinal nerve that is one of a series of ganglia lodging cell bodies of sensory neurons.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001264,,,,,,,BrendaTissueOBO,ganglion spinale|dorsal root ganglion|ganglion sensorium nervi spinalis,BTO:0001264,,,,,,,,,,,,,,,,,,,spinal ganglion,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000365,"[""PKN2 kinase domain""]",,Protein kinase N2; MGC150606; MGC71074; PAK2; Pak-2; PKN2; PKN2/PRK2; PRK2; PRKCL2; PRO2042,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Protein kinase N2; MGC150606; MGC71074; PAK2; Pak-2; PKN2; PKN2/PRK2; PRK2; PRKCL2; PRO2042,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000365,,,,,,,,,,,,,,,,,,,200348,,,,,,,,,PKN2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050214,"[""Lambert-Eaton myasthenic syndrome""]",,A neuromuscular junction disease that is characterized by an abnormality of acetylcholine (ACh) release at the neuromuscular junction which results from an autoimmune attack against voltage-gated calcium channels (VGCC) on the presynaptic motor nerve terminal.,false,,,http://purl.obolibrary.org/obo/DOID_439,,,,,,,,A neuromuscular junction disease that is characterized by an abnormality of acetylcholine (ACh) release at the neuromuscular junction which results from an autoimmune attack against voltage-gated calcium channels (VGCC) on the presynaptic motor nerve terminal.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050214,,,,NCI:C3155|UMLS_CUI:C0022972|MESH:D015624|ICD9CM:358.3|ICD10CM:G70.80|SNOMEDCT_US_2016_03_01:56989000|SNOMEDCT_US_2016_03_01:230688006,Lambert-Eaton syndrome|LEMS|Eaton-Lambert syndrome,,disease_ontology,,DOID:0050214,,,,,,,,,,,,,,,,,,,Lambert-Eaton myasthenic syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100020,"[""Rac-beta serine/threonine-protein kinase""]",,"A RAC-beta serine/threonine-protein kinase that is encoded in the genome of human. [PRO:CNA, UniProtKB:P31751] |RAC-beta serine/threonine-protein kinase (AKT2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300121,,,,,,,,"A RAC-beta serine/threonine-protein kinase that is encoded in the genome of human. [PRO:CNA, UniProtKB:P31751] |RAC-beta serine/threonine-protein kinase (AKT2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100020,,,,https://pharos.nih.gov/idg/targets/P31751,,,,,,,,,,,,,AKT2,,,P31751,,,,,,,,Rac-beta serine/threonine-protein kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200001,"[""HTR1A gene""]",,"A 5-hydroxytryptamine receptor 1A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08908] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402001,,,,,,,,"A 5-hydroxytryptamine receptor 1A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08908] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200001,,,,,,,,,,,,,,,,3350,HTR1A,ADRB2RL1|ADRBRL1,,,,,,,,,,HTR1A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3876,"[""colonic pseudo-obstruction""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3877|http://purl.obolibrary.org/obo/DOID_3878,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3876,,,,UMLS_CUI:C0009377|MESH:D003112|SNOMEDCT_US_2016_03_01:35065006,primary chronic pseudo-obstruction of colon (disorder),,disease_ontology,,DOID:3876,,,,,,,,,,,,,,,,,,,colonic pseudo-obstruction,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001485,"[""muscular system""]",,"The bodily system that is composed of skeletal, smooth, and cardiac muscle tissue and functions in movement of the body or of materials through the body, maintenance of posture, and heat production.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The bodily system that is composed of skeletal, smooth, and cardiac muscle tissue and functions in movement of the body or of materials through the body, maintenance of posture, and heat production.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001485,,,,,,,BrendaTissueOBO,muscle system|musculature|musculature system|Muskelsystem,BTO:0001485,,,,,,,,,,,,,,,,,,,muscular system,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4183,"[""pseudopseudohypoparathyroidism""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_4184,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4183,,,,OMIM:612463|UMLS_CUI:C0033835|SNOMEDCT_US_2016_03_01:8084001|SNOMEDCT_US_2016_03_01:190867002|SNOMEDCT_US_2016_03_01:237659007|MESH:D011556,Normocalcemic pseudohypoparathyroidism (disorder) [Ambiguous]|Pseudopseudohypoparathyroidism (disorder),,disease_ontology,,DOID:4183,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,pseudopseudohypoparathyroidism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12223,"[""specific bursitis often of occupational origin""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2965,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12223,,,,SNOMEDCT_US_2016_03_01:42812006|UMLS_CUI:C0158332|ICD9CM:727.2,Specific bursitides often of occupational origin|Specific bursitis often of occupational origin (disorder),,disease_ontology,,DOID:12223,,,,,,,,,,,,,,,,,,,specific bursitis often of occupational origin,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000296,"[""PHE93 in CDK4-cyclinD1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000296,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE93 in CDK4-cyclinD1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000327,"[""THR315 in ABL1(F317I)-nonphosphorylated""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000327,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR315 in ABL1(F317I)-nonphosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4626,"[""hydranencephaly""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060668,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4626,,,,ICD10CM:Q04.3|MESH:D006832|SNOMEDCT_US_2016_03_01:30023002|NCI:C98949|UMLS_CUI:C0020225,,,disease_ontology,,DOID:4626,,,,,,,,,,,,,,,,,,,hydranencephaly,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060786,"[""hypomyelinating leukodystrophy""]",,A leukodystrophy characterized by T2 hyperintensity and T1 iso- or hyperintensity of affected white matter in the central nervous system.,false,,,http://purl.obolibrary.org/obo/DOID_10579,,,,,,,,A leukodystrophy characterized by T2 hyperintensity and T1 iso- or hyperintensity of affected white matter in the central nervous system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060786,,,,OMIM:PS312080,HLD,,,,DOID:0060786,,,,,,,,,,,,,,,,,,,hypomyelinating leukodystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200814,"[""UTS2R gene""]",,"A urotensin-2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UKP6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A urotensin-2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UKP6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200814,,,,,,,,,,,,,,,,2837,UTS2R,GPR14,,,,,,,,,,UTS2R gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400090,"[""UPF0359 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400090,,,,,,,,,,,,,,,,,,,,,,,,,,,,UPF0359 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200805,"[""TAAR6 gene""]",,"A trace amine-associated receptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96RI8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A trace amine-associated receptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96RI8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200805,,,,,,,,,,,,,,,,319100,TAAR6,TA4|TAR4|TRAR4,,,,,,,,,,TAAR6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200045,"[""CACNA1H gene""]",,"This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (CAE). [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400388,,,,,,,,"This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (CAE). [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200045,,,,,,,,,,,,,,,,8912,CACNA1H,,,,,,,,,,,CACNA1H gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100023,"[""Alpha-protein kinase 1""]",,"An alpha-protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96QP1] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300123,,,,,,,,"An alpha-protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96QP1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100023,,,,https://pharos.nih.gov/idg/targets/Q96QP1,,,,,,,,,,,,,ALPK1,KIAA1527|LAK,,Q96QP1,,,,,,,,Alpha-protein kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200446,"[""RET gene""]",,"This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400216,,,,,,,,"This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200446,,,,,,,,,,,,,,,,5979,RET,CDHF12|CDHR16|PTC,,,,,,,,,,RET gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002874,"[""Rat-2 cell""]",,"This line was derived from the a 5-bromo-2'-deoxyuridine resistant strain of the Fischer rat fibroblast 3T3 like cell line, Rat1. Rat2 lacks detectable nuclear thymidine kinase, is highly transfectable by exogenous DNA and is phenotypically normal.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001958,,,,,,,,"This line was derived from the a 5-bromo-2'-deoxyuridine resistant strain of the Fischer rat fibroblast 3T3 like cell line, Rat1. Rat2 lacks detectable nuclear thymidine kinase, is highly transfectable by exogenous DNA and is phenotypically normal.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002874,,,,,,,BrendaTissueOBO,Rat2 cell,BTO:0002874,,,,,,,,,,,,,,,,,,,Rat-2 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000210,"[""MET86 in IKKE""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000210,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET86 in IKKE,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001044,"[""phagocyte""]",,"A cell, as a white blood cell, that engulfs and consumes foreign material, as microorganisms, and debris.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000574,,,,,,,,"A cell, as a white blood cell, that engulfs and consumes foreign material, as microorganisms, and debris.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001044,,,,,,,BrendaTissueOBO,,BTO:0001044,,,,,,,,,,,,,,,,,,,phagocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200313,"[""MET gene""]",,"The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400190,,,,,,,,"The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200313,,,,,,,,,,,,,,,,4233,MET,,,,,,,,,,,MET gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300512,"[""GABRB1 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300512,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRB1 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100060,"[""Voltage-dependent calcium channel gamma-6 subunit""]",,"A voltage-dependent calcium channel gamma-6 subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BXT2] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300336,,,,,,,,"A voltage-dependent calcium channel gamma-6 subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BXT2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100060,,,,https://pharos.nih.gov/idg/targets/Q9BXT2,,,,,,,,,,,,,CACNG6,,,Q9BXT2,,,,,,,,Voltage-dependent calcium channel gamma-6 subunit,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200572,"[""ZAP70 gene""]",,"This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03491041|http://www.drugtargetontology.org/dto/DTO_03400180,,,,,,,,"This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200572,,,,,,,,,,,,,,,,7535,ZAP70,SRK,,,,,,,,,,ZAP70 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100797,"[""Taste receptor type 2 member 7""]",,"A taste receptor type 2 member 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300014,,,,,,,,"A taste receptor type 2 member 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100797,,,,https://pharos.nih.gov/idg/targets/Q9NYW3,,,,,,,,,,,,,TAS2R7,,,Q9NYW3,,,,,,,,Taste receptor type 2 member 7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300037,"[""Dopamine receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300037,,,,,,,,,,,,,,,,,,,,,,,,,,,,Dopamine receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000658,"[""uterine adenocarcinoma cell""]",,"The most common form of endometrial carcinoma, containing tumor cells differentiated into glandular tissue with little or no stroma.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000604|http://purl.obolibrary.org/obo/BTO_0000257,,,,,,,,"The most common form of endometrial carcinoma, containing tumor cells differentiated into glandular tissue with little or no stroma.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000658,,,,,,,BrendaTissueOBO,endometrial carcinoma cell|endometrial adenocarcinoma cell|endometrioid adenocarcinoma cell,BTO:0000658,,,,,,,,,,,,,,,,,,,uterine adenocarcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001188,"[""root""]",,"The usually underground part of a seed plant body that originates usually from the hypocotyl, functions as an organ of absorption, aeration, and food storage or as a means of anchorage and support, and differs from a stem especially in lacking nodes, buds, and leaves.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The usually underground part of a seed plant body that originates usually from the hypocotyl, functions as an organ of absorption, aeration, and food storage or as a means of anchorage and support, and differs from a stem especially in lacking nodes, buds, and leaves.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001188,,,,,,,BrendaTissueOBO,,BTO:0001188,,,,,,,,,,,,,,,,,,,root,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100594,"[""Olfactory receptor 4K13""]",,"An olfactory receptor 4K13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH42] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4K13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH42] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100594,,,,https://pharos.nih.gov/idg/targets/Q8NH42,,,,,,,,,,,,,OR4K13,,,Q8NH42,,,,,,,,Olfactory receptor 4K13,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200532,"[""TNK1 gene""]",,"The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400118,,,,,,,,"The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200532,,,,,,,,,,,,,,,,8711,TNK1,,,,,,,,,,,TNK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100044,"[""Voltage-dependent t-type calcium channel subunit alpha-1g""]",,"A voltage-dependent T-type calcium channel subunit alpha-1G that is encoded in the genome of human. [PRO:WCB, UniProtKB:O43497] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300387,,,,,,,,"A voltage-dependent T-type calcium channel subunit alpha-1G that is encoded in the genome of human. [PRO:WCB, UniProtKB:O43497] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100044,,,,https://pharos.nih.gov/idg/targets/O43497,,,,,,,,,,,,,CACNA1G,KIAA1123,,O43497,,,,,,,,Voltage-dependent t-type calcium channel subunit alpha-1g,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2475,"[""chronic conjunctivitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_6195,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2475,,,,ICD9CM:372.1|SNOMEDCT_US_2016_03_01:193865006|ICD10CM:H10.4|ICD9CM:372.10|UMLS_CUI:C0155145|ICD10CM:H10.40|SNOMEDCT_US_2016_03_01:155163007|SNOMEDCT_US_2016_03_01:73762008|SNOMEDCT_US_2016_03_01:193869000|NCI:C35197,"chronic Conjunctivitis|chronic conjunctivitis NOS (disorder)|Unspecified chronic conjunctivitis (disorder)|chronic conjunctivitis, unspecified",,disease_ontology,,DOID:2475,,,,,,,,,,,,,,,,,,,chronic conjunctivitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200594,"[""OR4K13 gene""]",,"An olfactory receptor 4K13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH42] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4K13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH42] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200594,,,,,,,,,,,,,,,,390433,OR4K13,,,,,,,,,,,OR4K13 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300116,"[""CAMKL family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300116,,,,,,,,,,,,,,,,,,,,,,,,,,,,CAMKL family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200156,"[""KCNJ18 gene""]",,"This gene encodes a member of the inwardly rectifying potassium channel family. Transcription of this locus is regulated by thyroid hormone, and the encoded protein plays a role in resting membrane potential maintenance. Mutations in this locus have been associated with thyrotoxic hypokalemic periodic paralysis. [provided by RefSeq, Jan 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_01400423,,,,,,,,"This gene encodes a member of the inwardly rectifying potassium channel family. Transcription of this locus is regulated by thyroid hormone, and the encoded protein plays a role in resting membrane potential maintenance. Mutations in this locus have been associated with thyrotoxic hypokalemic periodic paralysis. [provided by RefSeq, Jan 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200156,,,,,,,,,,,,,,,,100134444,KCNJ18,,,,,,,,,,,KCNJ18 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12236,"[""primary biliary cirrhosis""]",,A liver cirrhosis characterized by chronic and slow progressive destruction of intrahepatic bile ducts.,false,,,http://purl.obolibrary.org/obo/DOID_5082|http://purl.obolibrary.org/obo/DOID_0060049,,,,,,,,A liver cirrhosis characterized by chronic and slow progressive destruction of intrahepatic bile ducts.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12236,,,DOID:1851,MESH:D008105|SNOMEDCT_US_2016_03_01:197311004|ICD10CM:K74.3|NCI:C27167|EFO:0004267|UMLS_CUI:C0008312|NCI:C51225|SNOMEDCT_US_2016_03_01:31712002|SNOMEDCT_US_2016_03_01:155815006|OMIM:613008|ORDO:186|ICD10CM:K74.5|OMIM:613007|SNOMEDCT_US_2016_03_01:1761006|OMIM:614221|OMIM:614220|UMLS_CUI:C0023892|SNOMEDCT_US_2016_03_01:266540000|OMIM:109720|ICD9CM:571.6,biliary liver cirrhosis|chronic nonsuppurative destructive cholangitis|cholestatic cirrhosis,,disease_ontology,,DOID:12236,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,primary biliary cirrhosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200352,"[""OR14A16 gene""]",,"An olfactory receptor 14A16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHC5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 14A16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHC5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200352,,,,,,,,,,,,,,,,284532,OR14A16,OR5AT1,,,,,,,,,,OR14A16 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2842,"[""Jervell-Lange Nielsen syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_2843,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2842,,,,NCI:C84793|MESH:D029593|OMIM:220400|SNOMEDCT_US_2016_03_01:373905003|UMLS_CUI:C0022387|SNOMEDCT_US_2016_03_01:49518001|OMIM:612347,Jervell and Lange-Nielson syndrome (disorder),,disease_ontology,,DOID:2842,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Jervell-Lange Nielsen syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1596,"[""mental depression""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3324,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1596,,,DOID:14672,NCI:C2982|SNOMEDCT_US_2016_03_01:41006004|SNOMEDCT_US_2016_03_01:192372006|ICD10CM:F32.9|MESH:D003863|SNOMEDCT_US_2016_03_01:154963001|UMLS_CUI:C0011570|SNOMEDCT_US_2016_03_01:307537002|ICD10CM:F33.9,,,disease_ontology,,DOID:1596,,,,,,,,,,,,,,,,,,,mental depression,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10480,"[""diaphragmatic eventration""]",,,false,,,http://purl.obolibrary.org/obo/DOID_10481,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10480,,,,NCI:C98912|UMLS_CUI:C0011981|SNOMEDCT_US_2016_03_01:268351009|ICD10CM:Q79.1|MESH:D003965|SNOMEDCT_US_2016_03_01:157006001|SNOMEDCT_US_2016_03_01:34168003,,,disease_ontology,,DOID:10480,,,,,,,,,,,,,,,,,,,diaphragmatic eventration,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10481,"[""diaphragm disease""]",,A muscular disease that is located_in the diaphragm.,false,,,http://purl.obolibrary.org/obo/DOID_0080000,,,,,,,,A muscular disease that is located_in the diaphragm.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10481,,,,ICD9CM:519.4|SNOMEDCT_US_2016_03_01:48475001|UMLS_CUI:C0152097|ICD10CM:J98.6|SNOMEDCT_US_2016_03_01:196182001,,,disease_ontology,,DOID:10481,,,,,,,,,,,,,,,,,,,diaphragm disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10488,"[""imperforate anus""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0080015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10488,,,,NCI:C84784|SNOMEDCT_US_2016_03_01:14118000|MESH:D001006|OMIM:207500|UMLS_CUI:C0003466|ICD10CM:Q42.3|SNOMEDCT_US_2016_03_01:204733009|SNOMEDCT_US_2016_03_01:204712000|SNOMEDCT_US_2016_03_01:156956004|OMIM:301800|SNOMEDCT_US_2016_03_01:204731006,Congenital or infantile occlusion of anus|Imperforate anus|Congenital atresia of anus|anal atresia,,disease_ontology,,DOID:10488,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,imperforate anus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10487,"[""Hirschsprung's disease""]",,A megacolon that is characterized by a blockage of the large intestine due to improper muscle movement in the bowel.,false,,,http://purl.obolibrary.org/obo/DOID_11372,,,,,,,,A megacolon that is characterized by a blockage of the large intestine due to improper muscle movement in the bowel.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10487,,,,OMIM:606874|OMIM:613711|ORDO:388|SNOMEDCT_US_2016_03_01:204742002|SNOMEDCT_US_2016_03_01:204744001|UMLS_CUI:C0019569|SNOMEDCT_US_2016_03_01:6687001|SNOMEDCT_US_2016_03_01:204739008|SNOMEDCT_US_2016_03_01:204738000|OMIM:142623|NCI:C34700|ICD10CM:Q43.1|MESH:D006627|OMIM:613712|SNOMEDCT_US_2016_03_01:360436002|OMIM:606875|OMIM:600155|SNOMEDCT_US_2016_03_01:367495003|OMIM:611644|OMIM:608462|OMIM:600156|SNOMEDCT_US_2016_03_01:156957008,pelvirectal achalasia|macrocolon|total intestinal aganglionosis|aganglionic megacolon|congenital megacolon|Hirschsprung disease,,disease_ontology,,DOID:10487,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,Hirschsprung's disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060158,"[""acquired metabolic disease""]",,"A disease of metabolism that has _material_basis_in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption.",false,,,http://purl.obolibrary.org/obo/DOID_0014667,,,,,,,,"A disease of metabolism that has _material_basis_in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060158,lschriml,2011-08-24T02:53:03Z,,,,,disease_ontology,,DOID:0060158,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,acquired metabolic disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060159,"[""organic acidemia""]",,An amino acid metabolic disorder that disrupts normal amino acid metabolism causing a building up of branched-chain amino acids.,false,,,http://purl.obolibrary.org/obo/DOID_9252,,,,,,,,An amino acid metabolic disorder that disrupts normal amino acid metabolism causing a building up of branched-chain amino acids.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060159,lschriml,2011-08-26T11:17:14Z,,,organic acid metabolism disorder|organic aciduria,,disease_ontology,,DOID:0060159,,,,,,,,,,,,,,,,,,,organic acidemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060151,"[""tactile agnosia""]",,An agnosia that is a loss of the ability to recognize or identify objects by touch alone.,false,,,http://purl.obolibrary.org/obo/DOID_4090,,,,,,,,An agnosia that is a loss of the ability to recognize or identify objects by touch alone.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060151,lschriml,2011-08-22T12:04:56Z,,,,,disease_ontology,,DOID:0060151,,,,,,,,,,,,,,,,,,,tactile agnosia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400493,"[""Alpha-4/CHRNA4 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400493,,,,,,,,,,,,,,,,,,,,,,,,,,,,Alpha-4/CHRNA4 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200141,"[""GPR128 gene""]",,"A G-protein coupled receptor 128 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96K78] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,"A G-protein coupled receptor 128 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96K78] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200141,,,,,,,,,,,,,,,,84873,GPR128,,,,,,,,,,,GPR128 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200585,"[""GK gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200585,,,,,,,,,,,,,,,,,,,,,,,,,,,,GK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000076,"[""(±)-adrenaline""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_32952,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000076,,,,,,,,,,,,,,,,,,,,,,,,,,,,(±)-adrenaline,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300005,"[""Class F frizzled-type""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300001,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300005,,,,,,,,,,,,,,,,,,,,,,,,,,,,Class F frizzled-type,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1561,"[""cognitive disorder""]",,"A disease of mental health that affects cognitive functions including memory processing, perception and problem solving.",false,,,http://purl.obolibrary.org/obo/DOID_150,,,,,,,,"A disease of mental health that affects cognitive functions including memory processing, perception and problem solving.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1561,,,,MESH:D019965|SNOMEDCT_US_2016_03_01:111479008|NCI:C34870|SNOMEDCT_US_2016_03_01:106014008|UMLS_CUI:C0029227|ICD10CM:F09,cognitive disease,,disease_ontology,Organic Mental disorder,DOID:1561,,,,,,,,,,,,,,,,,,,cognitive disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100592,"[""Olfactory receptor 4k3""]",,"An olfactory receptor 4K3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R72] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4K3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R72] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100592,,,,https://pharos.nih.gov/idg/targets/Q96R72,,,,,,,,,,,,,OR4K3,OR4K3P,,Q96R72,,,,,,,,Olfactory receptor 4k3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1921,"[""Klinefelter's syndrome""]",,"No OMIM mapping, confirmed by DO. [LS].",false,,,http://purl.obolibrary.org/obo/DOID_0080014,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1921,,,,SNOMEDCT_US_2016_03_01:205696000|ICD9CM:758.7|UMLS_CUI:C0022735|SNOMEDCT_US_2016_03_01:405770005|SNOMEDCT_US_2016_03_01:205712007|ICD10CM:Q98.0|ICD10CM:Q98.4|SNOMEDCT_US_2016_03_01:157021007|SNOMEDCT_US_2016_03_01:405769009|MESH:D007713|SNOMEDCT_US_2016_03_01:22053006|NCI:C34752|SNOMEDCT_US_2016_03_01:268357008|SNOMEDCT_US_2016_03_01:205701007,Hypogonadotropic Hypogonadism|Klinefelter syndrome|XXY syndrome|XXY trisomy,,disease_ontology,,DOID:1921,,,,,,,,,,,,,,,,,"No OMIM mapping, confirmed by DO. [LS].",,Klinefelter's syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200162,"[""GRK6 gene""]",,"This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400271,,,,,,,,"This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200162,,,,,,,,,,,,,,,,2870,GRK6,GPRK6,,,,,,,,,,GRK6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10456,"[""tonsillitis""]",,"An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. Tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). Swelling of the cheeks and neck may occur.",false,,,http://purl.obolibrary.org/obo/DOID_974,,,,,,,,"An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. Tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). Swelling of the cheeks and neck may occur.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10456,,,DOID:10454|DOID:13751,ICD9CM:474.00|MESH:D014069|SNOMEDCT_US_2016_03_01:195665006|UMLS_CUI:C0149517|SNOMEDCT_US_2016_03_01:90979004|SNOMEDCT_US_2016_03_01:90176007|ICD10CM:J35.01|UMLS_CUI:C0040425|SNOMEDCT_US_2016_03_01:195794009|NCI:C116006|SNOMEDCT_US_2016_03_01:155530006,Throat infection - tonsillitis|chronic tonsillitis,,disease_ontology,,DOID:10456,,,,,,,,,,,,,,,,,,,tonsillitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10458,"[""legionellosis""]",,"A primary bacterial infectious disease that results_in infection located_in respiratory tract, has_material_basis_in Legionella pneumophila, which is transmitted_by inhalation of droplets containing bacteria. The symptoms include dry cough, fever, headache and diarrhea.",false,,,http://purl.obolibrary.org/obo/DOID_0050338,,,,,,,,"A primary bacterial infectious disease that results_in infection located_in respiratory tract, has_material_basis_in Legionella pneumophila, which is transmitted_by inhalation of droplets containing bacteria. The symptoms include dry cough, fever, headache and diarrhea.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10458,,,,SNOMEDCT_US_2016_03_01:26726000|MESH:D007876|UMLS_CUI:C0023240,Legionella infection (disorder),,disease_ontology,,DOID:10458,http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease,,,,,,,,,,,,,,,,,,legionellosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10457,"[""Legionnaires' disease""]",,"A legionellosis that is characterized by severe form of infection producing pneumonia. Symptoms include fever, chills, and cough.",false,,,http://purl.obolibrary.org/obo/DOID_10458,,,,,,,,"A legionellosis that is characterized by severe form of infection producing pneumonia. Symptoms include fever, chills, and cough.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10457,,,,ICD10CM:A48.1|ICD9CM:482.84|SNOMEDCT_US_2016_03_01:269574000|SNOMEDCT_US_2016_03_01:312403005|SNOMEDCT_US_2016_03_01:74881002|SNOMEDCT_US_2016_03_01:195889001|SNOMEDCT_US_2016_03_01:154315008|UMLS_CUI:C0023241|SNOMEDCT_US_2016_03_01:266186009|MESH:D007877,Legionella pneumonia (disorder)|Infection by Legionella pneumophilia (disorder)|(Legionella) or (Legionnaire's disease),,disease_ontology,,DOID:10457,http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease,,,,,,,,,,,,,,,,,,Legionnaires' disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10459,"[""common cold""]",,"An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. This is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus.",false,,,http://purl.obolibrary.org/obo/DOID_974,,,,,,,,"An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. This is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10459,,,,ICD10CM:J00|SNOMEDCT_US_2016_03_01:155497009|SNOMEDCT_US_2016_03_01:82272006|NCI:C34500|SNOMEDCT_US_2016_03_01:195648002|SNOMEDCT_US_2016_03_01:232342002|NCI:C78599|ICD9CM:460|UMLS_CUI:C0009443|SNOMEDCT_US_2016_03_01:232341009|SNOMEDCT_US_2016_03_01:266377009|SNOMEDCT_US_2016_03_01:54150009|MESH:D003139,"Nasopharyngitis, acute|Nasopharyngitis - acute|acute rhinitis|rhino-sinusitis|acute coryza|acute nasopharyngitis [common cold]|acute Nasopharyngitis|Acute viral rhinopharyngitis",,disease_ontology,,DOID:10459,,,,,,,,,,,,,,,,,,,common cold,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200823,"[""VN1R4 gene""]",,"A vomeronasal type-1 receptor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z5H5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400016,,,,,,,,"A vomeronasal type-1 receptor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z5H5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200823,,,,,,,,,,,,,,,,317703,VN1R4,V1RL4,,,,,,,,,,VN1R4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100130,"[""Adhesion G-protein coupled receptor F2""]",,"A G-protein coupled receptor 111 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,"A G-protein coupled receptor 111 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100130,,,,https://pharos.nih.gov/idg/targets/Q8IZF7,,,,,,,,,,,,,GPR111,ADGRF2|PGR20,,Q8IZF7,,,,,,,,Adhesion G-protein coupled receptor F2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004410,"[""culture condition:CD8+ cell""]",,"The CD8 co-receptor is predominantly expressed on the surface of cytotoxic T cells, but can also be found on natural killer cells and dendritic cells.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002008,,,,,,,,"The CD8 co-receptor is predominantly expressed on the surface of cytotoxic T cells, but can also be found on natural killer cells and dendritic cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004410,Marion,2010-02-01T11:01:31Z,,,,,BrendaTissueOBO,,BTO:0004410,,,,,,,,,,,,,,,,,,,culture condition:CD8+ cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200453,"[""OR5AS1 gene""]",,"An olfactory receptor 5AS1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N127] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5AS1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N127] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200453,,,,,,,,,,,,,,,,219447,OR5AS1,,,,,,,,,,,OR5AS1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400186,"[""STE11 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400113,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400186,,,,,,,,,,,,,,,,,,,,,,,,,,,,STE11 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003340,"[""CL-3 cell""]",,Human lung adenocarcinoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001911,,,,,,,,Human lung adenocarcinoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003340,,,,,,,BrendaTissueOBO,,BTO:0003340,,,,,,,,,,,,,,,,,,,CL-3 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000914,"[""natural killer cell""]",,A large granular lymphocyte capable of killing a tumor or microbial cell without prior exposure to the target cell and without having it presented with or marked by a histocompatibility antigen.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0004716|http://purl.obolibrary.org/obo/BTO_0004717,,,,,,,,A large granular lymphocyte capable of killing a tumor or microbial cell without prior exposure to the target cell and without having it presented with or marked by a histocompatibility antigen.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000914,,,,,,,BrendaTissueOBO,NK cell,BTO:0000914,,,,,,,,,,,,,,,,,,,natural killer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000281,"[""MLCK kinase domain""]",,Myosin light chain kinase 3; caMLCK; MGC126319; MGC126320; MLCK; MLCK2; MYLK3,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Myosin light chain kinase 3; caMLCK; MGC126319; MGC126320; MLCK; MLCK2; MYLK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000281,,,,,,,,,,,,,,,,,,,200266,,,,,,,,,MLCK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200068,"[""CLCA4 gene""]",,"The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Alternative splicing results in multiple transcript variants, only one of which is thought to be protein coding. [provided by RefSeq, Dec 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400339,,,,,,,,"The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Alternative splicing results in multiple transcript variants, only one of which is thought to be protein coding. [provided by RefSeq, Dec 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200068,,,,,,,,,,,,,,,,22802,CLCA4,CaCC2,,,,,,,,,,CLCA4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100593,"[""Inositol hexakisphosphate kinase 3""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100593,,,,,,,,,,,,,,,,,IP6K3,,,Q96PC2,,,,,,,,Inositol hexakisphosphate kinase 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004358,"[""sinus node""]",,A small mass of tissue that is embedded in the musculature of the right atrium of higher vertebrates and that originates the impulses stimulating the heartbeat.,false,,,http://purl.obolibrary.org/obo/BTO_0004190|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A small mass of tissue that is embedded in the musculature of the right atrium of higher vertebrates and that originates the impulses stimulating the heartbeat.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004358,,,,,,,BrendaTissueOBO,sinoatrial node,BTO:0004358,,,,,,,,,,,,,,,,,,,sinus node,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001257,"[""flexor""]",,A muscle that when contracted acts to bend a joint or limb in the body.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001103,,,,,,,,A muscle that when contracted acts to bend a joint or limb in the body.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001257,,,,,,,BrendaTissueOBO,,BTO:0001257,,,,,,,,,,,,,,,,,,,flexor,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200482,"[""OR1D4 gene""]",,"An olfactory receptor 1D4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47884] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1D4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47884] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200482,,,,,,,,,,,,,,,,653166,OR1D4,,,,,,,,,,,OR1D4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004649,"[""fin""]",,An external membranous process of an aquatic animal as a fish used in propelling or guiding the body.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,An external membranous process of an aquatic animal as a fish used in propelling or guiding the body.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004649,mgr,2010-05-05T08:09:22Z,,,,,BrendaTissueOBO,,BTO:0004649,,,,,,,,,,,,,,,,,,,fin,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300421,"[""KCNJ10 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300421,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ10 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005189,"[""head kidney""]",,The kidney of the channel catfish is completely separated into the head and trunk kidneys. The head kidney is involved in endocrine and hemopoietic functions and the trunk kidney functions primarily as part of the excretory system.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000671|http://purl.obolibrary.org/obo/UBERON_0002113,,,,,,,,The kidney of the channel catfish is completely separated into the head and trunk kidneys. The head kidney is involved in endocrine and hemopoietic functions and the trunk kidney functions primarily as part of the excretory system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005189,XPMUser,2011-09-01T11:31:28Z,,,,,BrendaTissueOBO,,BTO:0005189,,,,,,,,,,,,,,,,,,,head kidney,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400190,"[""MET family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400190,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3355,"[""fibrosarcoma""]",,A connective tissue cancer that has_material_basis_in fibrous connective tissue and characterized by the presence of immature proliferating fibroblasts or undifferentiated anaplastic spindle cells in a storiform pattern.,false,,,http://purl.obolibrary.org/obo/DOID_201,,,,,,,,A connective tissue cancer that has_material_basis_in fibrous connective tissue and characterized by the presence of immature proliferating fibroblasts or undifferentiated anaplastic spindle cells in a storiform pattern.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3355,,,DOID:3509|DOID:156,SNOMEDCT_US_2016_03_01:443250000|UMLS_CUI:C1336021|MESH:D005354|NCI:C7075|NCI:C3043|UMLS_CUI:C0016057|NCI:C6605|SNOMEDCT_US_2016_03_01:53654007|MESH:D018218|UMLS_CUI:C0206643,Fibrocytic tumor|fibrous tissue neoplasm|fibrosarcoma of soft tissue,,disease_ontology,,DOID:3355,,,,,,,,,,,,,,,,,,,fibrosarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100397,"[""[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial""]",,"A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15120] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300131,,,,,,,,"A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15120] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100397,,,,https://pharos.nih.gov/idg/targets/Q15120,,,,,,,,,,,,,PDK3,PDHK3,,Q15120,,,,,,,,"[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117482,"[""Retinoic acid receptor alpha""]",,"A retinoic acid receptor alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10276] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117461,,,,,,,,"A retinoic acid receptor alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10276] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117482,,,,https://pharos.nih.gov/idg/targets/P10276,,,,,,,,,,,,,RARA,,,P10276,,,,,,,,Retinoic acid receptor alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005565,"[""embryonic tracheal system""]",,The embryonic tracheal system or the fruitfly is an epithelial tubular network established from defined sets of ectodermal precursor cells.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The embryonic tracheal system or the fruitfly is an epithelial tubular network established from defined sets of ectodermal precursor cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005565,Marion,2014-03-01T18:31:56Z,,,,,BrendaTissueOBO,larval tracheal system,BTO:0005565,,,,,,,,,,,,,,,,,,,embryonic tracheal system,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400093,"[""Alpha adrenoceptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400022,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400093,,,,,,,,,,,,,,,,,,,,,,,,,,,,Alpha adrenoceptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100255,"[""Ribosomal protein s6 kinase alpha-5""]",,"A ribosomal protein S6 kinase alpha-5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75582] |ribosomal protein s6 kinase alpha-5 (RPS6KA5(Kin.Dom.1-N-terminal))  with  no mutation  in a nonphosphorylated state|ribosomal protein s6 kinase alpha-5 (RPS6KA5(Kin.Dom.2-C-terminal))  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300281,,,,,,,,"A ribosomal protein S6 kinase alpha-5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75582] |ribosomal protein s6 kinase alpha-5 (RPS6KA5(Kin.Dom.1-N-terminal))  with  no mutation  in a nonphosphorylated state|ribosomal protein s6 kinase alpha-5 (RPS6KA5(Kin.Dom.2-C-terminal))  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100255,,,,https://pharos.nih.gov/idg/targets/O75582,,,,,,,,,,,,,RPS6KA5,MSK1,,O75582,,,,,,,,Ribosomal protein s6 kinase alpha-5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001514,"[""biliary epithelial cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000414,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001514,,,,,,,BrendaTissueOBO,,BTO:0001514,,,,,,,,,,,,,,,,,,,biliary epithelial cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400065,"[""Melatonin receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400065,,,,,,,,,,,,,,,,,,,,,,,,,,,,Melatonin receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001820,"[""subcommissural organ""]",,"An ependymal derivative located at the junction of the third ventricle and the cerebral aqueduct, secreting somatostatin.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"An ependymal derivative located at the junction of the third ventricle and the cerebral aqueduct, secreting somatostatin.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001820,,,,,,,BrendaTissueOBO,,BTO:0001820,,,,,,,,,,,,,,,,,,,subcommissural organ,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000360,"[""THR493 in RSK2(Kin.Dom.2-C-terminal)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000360,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR493 in RSK2(Kin.Dom.2-C-terminal),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_870,"[""neuropathy""]",,A nervous system disease that is located_in nerves or nerve cells.,false,,,http://purl.obolibrary.org/obo/DOID_574,,,,,,,,A nervous system disease that is located_in nerves or nerve cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:870,,,,ICD10CM:G62.9|SNOMEDCT_US_2016_03_01:42658009|NCI:C4731|SNOMEDCT_US_2016_03_01:386033004|UMLS_CUI:C0442874|SNOMEDCT_US_2016_03_01:277878001|SNOMEDCT_US_2016_03_01:264554005|SNOMEDCT_US_2016_03_01:193167000|SNOMEDCT_US_2016_03_01:277317008,peripheral neuropathy,,disease_ontology,,DOID:870,,,,,,,,,,,,,,,,,,,neuropathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_874,"[""bacterial pneumonia""]",,A pneumonia involving inflammation of the lungs caused by bacteria.,false,,,http://purl.obolibrary.org/obo/DOID_552,,,,,,,,A pneumonia involving inflammation of the lungs caused by bacteria.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:874,,,DOID:13815,NCI:C26704|SNOMEDCT_US_2016_03_01:195892002|SNOMEDCT_US_2016_03_01:53084003|MESH:D018410|SNOMEDCT_US_2016_03_01:155553007|ICD9CM:482.9|ICD10CM:J15.9|UMLS_CUI:C0004626|SNOMEDCT_US_2016_03_01:195891009,Pneumonia due to other gram-negative bacteria|gram-negative pneumonia,,disease_ontology,,DOID:874,http://purl.obolibrary.org/obo/doid#GOLD,,,,,,,,,,,,,,,,,,bacterial pneumonia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200107,"[""GABRA1 gene""]",,"This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400506,,,,,,,,"This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200107,,,,,,,,,,,,,,,,2554,GABRA1,,,,,,,,,,,GABRA1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300250,"[""BARK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300127,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300250,,,,,,,,,,,,,,,,,,,,,,,,,,,,BARK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14018,"[""alcoholic liver cirrhosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5082,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14018,,,,ICD10CM:K70.3|SNOMEDCT_US_2016_03_01:235894003|MESH:D008104|CSP:1754-7677|SNOMEDCT_US_2016_03_01:75393009|SNOMEDCT_US_2016_03_01:197280008|SNOMEDCT_US_2016_03_01:420054005|SNOMEDCT_US_2016_03_01:266467008|NCI:C34782|UMLS_CUI:C0023891|ICD9CM:571.2|SNOMEDCT_US_2016_03_01:155811002,"Portal cirrhosis|Laennec's cirrhosis, alcoholic|Alcoholic cirrhosis of liver|Laennec's cirrhosis|Alcoholic Cirrhosis",,disease_ontology,,DOID:14018,,,,,,,,,,,,,,,,,,,alcoholic liver cirrhosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100541,"[""Testis-specific serine/threonine-protein kinase 2""]",,"A testis-specific serine/threonine-protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96PF2] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300238,,,,,,,,"A testis-specific serine/threonine-protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96PF2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100541,,,,https://pharos.nih.gov/idg/targets/Q96PF2,,,,,,,,,,,,,TSSK2,DGSG|SPOGA2|STK22B,,Q96PF2,,,,,,,,Testis-specific serine/threonine-protein kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002269,"[""JEG-3 cell""]",,Human choriocarcinoma cell line; established from a human gestational choriocarcinoma which was taken at autopsy from a cerebral metastasis; serial sister cell line of cell line BEWO.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001575,,,,,,,,Human choriocarcinoma cell line; established from a human gestational choriocarcinoma which was taken at autopsy from a cerebral metastasis; serial sister cell line of cell line BEWO.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002269,,,,,,,BrendaTissueOBO,JEG3 cell,BTO:0002269,,,,,,,,,,,,,,,,,,,JEG-3 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_24431,"[""Chemical entity""]",grouped_by_chemistry|.,"
A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.
",false,,,http://www.w3.org/2002/07/owl#Thing,,,,,,,,"
A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chemical entity,,chebi_ontology,grouped_by_chemistry|.,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:24431,,,,,Chemical entity|chemical entity,,CHEBI:24431,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400245,"[""AMPK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400116,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400245,,,,,,,,,,,,,,,,,,,,,,,,,,,,AMPK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200550,"[""TYRO3 gene""]",,"The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400189,,,,,,,,"The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200550,,,,,,,,,,,,,,,,7301,TYRO3,BYK|DTK|RSE,,,,,,,,,,TYRO3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000929,"[""neural retina""]",,"Layer of nerve cells in the retina, embryologically part of the brain. The incoming light passes through nerve-fibres and intermediary nerve cells of the neural retina, before encountering the light-sensitive rods and cones at the interface between neural retina and the pigmented retinal epithelium.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Layer of nerve cells in the retina, embryologically part of the brain. The incoming light passes through nerve-fibres and intermediary nerve cells of the neural retina, before encountering the light-sensitive rods and cones at the interface between neural retina and the pigmented retinal epithelium.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000929,,,,,,,BrendaTissueOBO,,BTO:0000929,,,,,,,,,,,,,,,,,,,neural retina,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100308,"[""Microtubule-associated serine/threonine-protein kinase 3""]",,"A microtubule-associated serine/threonine-protein kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60307] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300160,,,,,,,,"A microtubule-associated serine/threonine-protein kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60307] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100308,,,,https://pharos.nih.gov/idg/targets/O60307,,,,,,,,,,,,,MAST3,KIAA0561,,O60307,,,,,,,,Microtubule-associated serine/threonine-protein kinase 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000415,"[""epithelioma cell""]",,"A neoplasm cell of epithelial origin, ranging from benign (adenoma and papilloma) to malignant (carcinoma).",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A neoplasm cell of epithelial origin, ranging from benign (adenoma and papilloma) to malignant (carcinoma).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000415,,,,,,,BrendaTissueOBO,,BTO:0000415,,,,,,,,,,,,,,,,,,,epithelioma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200309,"[""OR10H3 gene""]",,"An olfactory receptor 10H3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60404] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10H3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60404] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200309,,,,,,,,,,,,,,,,26532,OR10H3,,,,,,,,,,,OR10H3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100487,"[""Olfactory receptor 1f1""]",,"An olfactory receptor 1F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43749] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43749] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100487,,,,https://pharos.nih.gov/idg/targets/O43749,,,,,,,,,,,,,OR1F1,OLFMF|OR1F10|OR1F4|OR1F5|OR1F6|OR1F7|OR1F8|OR1F9,,O43749,,,,,,,,Olfactory receptor 1f1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4006,"[""bladder urothelial carcinoma""]",,A bladder carcinoma that has_material_basis_in transitional cells located_in the lining of the bladder.,false,,,http://purl.obolibrary.org/obo/DOID_2671|http://purl.obolibrary.org/obo/DOID_4007,,,,,,,,A bladder carcinoma that has_material_basis_in transitional cells located_in the lining of the bladder.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4006,,,,NCI:C39851|SNOMEDCT_US_2016_03_01:255109008|SNOMEDCT_US_2016_03_01:393562002|UMLS_CUI:C0279680,urinary bladder urothelial carcinoma|bladder transitional cell carcinoma|transitional cell carcinoma of bladder|urothelial bladder carcinoma,,disease_ontology,,DOID:4006,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,bladder urothelial carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200706,"[""OR8K5 gene""]",,"An olfactory receptor 8K5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH50] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 8K5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH50] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200706,,,,,,,,,,,,,,,,219453,OR8K5,,,,,,,,,,,OR8K5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200657,"[""OR6C4 gene""]",,"An olfactory receptor 6C4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6C4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200657,,,,,,,,,,,,,,,,341418,OR6C4,,,,,,,,,,,OR6C4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200451,"[""OR5AP2 gene""]",,"An olfactory receptor 5AP2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5AP2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200451,,,,,,,,,,,,,,,,338675,OR5AP2,,,,,,,,,,,OR5AP2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000671,"[""kidney""]",,"1: One of a pair of vertebrate organs situated in the body cavity near the spinal column that excrete waste products of metabolism, in humans are bean-shaped organs about 4 1/2 inches (11 1/2 centimeters) long lying behind the peritoneum in a mass of fatty tissue, and consist chiefly of nephrons by which urine is secreted, collected, and discharged into a main cavity whence it is conveyed by the ureter to the bladder. 2: Any of various excretory organs of invertebrate animals.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001491|http://purl.obolibrary.org/obo/BTO_0000431|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,,"1: One of a pair of vertebrate organs situated in the body cavity near the spinal column that excrete waste products of metabolism, in humans are bean-shaped organs about 4 1/2 inches (11 1/2 centimeters) long lying behind the peritoneum in a mass of fatty tissue, and consist chiefly of nephrons by which urine is secreted, collected, and discharged into a main cavity whence it is conveyed by the ureter to the bladder. 2: Any of various excretory organs of invertebrate animals.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000671,,,,,,,BrendaTissueOBO,,BTO:0000671,,,,,,,,,,,,,,,,,,,kidney,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000136,"[""EPHA4 kinase domain""]",,EPH receptor A4; EPHA4; HEK8; SEK; TYRO1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,EPH receptor A4; EPHA4; HEK8; SEK; TYRO1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000136,,,,,,,,,,,,,,,,,,,200138,,,,,,,,,EPHA4 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100310,"[""Megakaryocyte-associated tyrosine-protein kinase""]",,"A megakaryocyte-associated tyrosine-protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42679] |megakaryocyte-associated tyrosine-protein kinase (CTK)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300144,,,,,,,,"A megakaryocyte-associated tyrosine-protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42679] |megakaryocyte-associated tyrosine-protein kinase (CTK)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100310,,,,https://pharos.nih.gov/idg/targets/P42679,,,,,,,,,,,,,MATK,CTK|HYL,,P42679,,,,,,,,Megakaryocyte-associated tyrosine-protein kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200762,"[""RXFP2 gene""]",,"A relaxin receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8WXD0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A relaxin receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8WXD0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200762,,,,,,,,,,,,,,,,122042,RXFP2,GPR106|GREAT|LGR8,,,,,,,,,,RXFP2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001097,"[""pollen""]",,The structure into which a haploid microspore develops; contains a halpoid tube nucleus and two haploid sperm nuclei at maturity.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The structure into which a haploid microspore develops; contains a halpoid tube nucleus and two haploid sperm nuclei at maturity.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001097,,,,,,,BrendaTissueOBO,pollen grain|male generative cell,BTO:0001097,,,,,,,,,,,,,,,,,,,pollen,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000399,"[""THR790 in EGFR(L747-S752del, P753S)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000399,,,,,,,,,,,,,,,,,,,,,,,,,,,,"THR790 in EGFR(L747-S752del, P753S)",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200383,"[""SCYL3 gene""]",,"This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400199,,,,,,,,"This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200383,,,,,,,,,,,,,,,,57147,SCYL3,PACE1,,,,,,,,,,SCYL3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12305,"[""Bloch-Sulzberger syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_10123,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12305,,,,SNOMEDCT_US_2016_03_01:806001|OMIM:308300|UMLS_CUI:C0021171|SNOMEDCT_US_2016_03_01:367520004|MESH:D007184|ICD10CM:Q82.3|NCI:C84787|SNOMEDCT_US_2016_03_01:205567005,Incontinentia pigmenti (disorder)|Incontinentia pigmenti syndrome (disorder),,disease_ontology,,DOID:12305,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Bloch-Sulzberger syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12306,"[""vitiligo""]",,A hypersensitivity reaction type II disease that causes depigmentation of patches of skin resulting from loss of function or death of melanoctyes.,false,,,http://purl.obolibrary.org/obo/DOID_417,,,,,,,,A hypersensitivity reaction type II disease that causes depigmentation of patches of skin resulting from loss of function or death of melanoctyes.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12306,,,,ICD9CM:709.01|EFO:0004208|UMLS_CUI:C0042900|MESH:D014820|ICD10CM:L80|OMIM:193200|SNOMEDCT_US_2016_03_01:156437000|NCI:C26915|SNOMEDCT_US_2016_03_01:56727007,,,disease_ontology,,DOID:12306,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,vitiligo,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002014,"[""B16-F10 cell""]",,"Mouse, C57BL/6, melanoma cell line.",false,,,http://purl.obolibrary.org/obo/BTO_0000849|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Mouse, C57BL/6, melanoma cell line.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002014,,,,,,,BrendaTissueOBO,B16F10 cell,BTO:0002014,,,,,,,,,,,,,,,,,,,B16-F10 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003505,"[""T-cell chronic lymphocytic leukemia cell""]",,"2-5% of all chronic lymphoproliferative disorders in the West, and 5-6% in the Chinese population. Large granular lymphocytes (LGLs) with the nucleus of a small lymphocyte but abundant cytoplasm and fine or coarse azurophilic granules; ultrastructural examination may reveal characteristic parallel tubular arrays; the LGLs are often >2x109/L.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001546,,,,,,,,"2-5% of all chronic lymphoproliferative disorders in the West, and 5-6% in the Chinese population. Large granular lymphocytes (LGLs) with the nucleus of a small lymphocyte but abundant cytoplasm and fine or coarse azurophilic granules; ultrastructural examination may reveal characteristic parallel tubular arrays; the LGLs are often >2x109/L.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003505,,,,,,,BrendaTissueOBO,T-cell large granular lymphocytic leukemia cell|large granular lymphocytosis cell|T-LGL cell|Tgamma lymphoproliferative disorder cell,BTO:0003505,,,,,,,,,,,,,,,,,,,T-cell chronic lymphocytic leukemia cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300348,"[""Fxyd family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300348,,,,,,,,,,,,,,,,,,,,,,,,,,,,Fxyd family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_16977,"[""L-alanine""]","89.09322|C[C@H](N)C(O)=O|QNAYBMKLOCPYGJ-REOHCLBHSA-N|(S)-alanine|C3H7NO2|InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1|L-alpha-alanine|A|L-alpha-Alanine|(2S)-2-aminopropanoic acid|L-Alanin|89.048|(S)-2-aminopropanoic acid|L-2-Aminopropionic acid|ALANINE|0|Ala",The L-enantiomer of alanine.,false,,,http://purl.obolibrary.org/obo/CHEBI_33709,,,,,,,Wikipedia:Alanine|KEGG:D00012|YMDB:YMDB00154|Beilstein:1720248|CAS:56-41-7|PMID:18235971|MetaCyc:ALPHA-ALANINE|KEGG:C00041|PMID:22735334|Gmelin:49628|KNApSAcK:C00001332|ECMDB:ECMDB00161|DrugBank:DB00160|Reaxys:1720248|PMID:3275662|PDBeChem:ALA_LFOH|HMDB:HMDB00161|Drug_Central:4255,The L-enantiomer of alanine.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:40735|CHEBI:46308|CHEBI:13069|CHEBI:40734|CHEBI:6171|CHEBI:21216,,L-alanine|L-Alanine,,chebi_ontology,"89.09322|C[C@H](N)C(O)=O|QNAYBMKLOCPYGJ-REOHCLBHSA-N|(S)-alanine|C3H7NO2|InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1|L-alpha-alanine|A|L-alpha-Alanine|(2S)-2-aminopropanoic acid|L-Alanin|89.048|(S)-2-aminopropanoic acid|L-2-Aminopropionic acid|ALANINE|0|Ala",,,CHEBI:16977,,,,,,,,,,,,,,,,,,,,,,,CHEBI:16977,,,,,L-alanine,,CHEBI:16977,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200613,"[""NME1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200613,,,,,,,,,,,,,,,,,,,,,,,,,,,,NME1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491016,"[""Phosphofructokinase type A (PFKA) family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400325,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491016,,,,,,,,,,,,,,,,,,,,,,,,,,,,Phosphofructokinase type A (PFKA) family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200349,"[""MYLK4 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400196,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200349,,,,,,,,,,,,,,,,340156,MYLK4,SGK085,,,,,,,,,,MYLK4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100593,"[""Olfactory receptor 4K5""]",,"An olfactory receptor 4K5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4K5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100593,,,,https://pharos.nih.gov/idg/targets/Q8NGD3,,,,,,,,,,,,,OR4K5,,,Q8NGD3,,,,,,,,Olfactory receptor 4K5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000706,"[""large intestine""]",,"The more terminal division of the vertebrate intestine that is wider and shorter than the small intestine, typically divided into cecum, colon, and rectum, and concerned especially with the resorption of water and the formation of feces.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The more terminal division of the vertebrate intestine that is wider and shorter than the small intestine, typically divided into cecum, colon, and rectum, and concerned especially with the resorption of water and the formation of feces.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000706,,,,,,,BrendaTissueOBO,large bowel|intestinum crassum,BTO:0000706,,,,,,,,,,,,,,,,,,,large intestine,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000354,"[""THR413 in LIMK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000354,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR413 in LIMK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100123,"[""Ephrin-a1""]",,"An ephrin-A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P20827] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391040,,,,,,,,"An ephrin-A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P20827] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100123,,,,https://pharos.nih.gov/idg/targets/P20827,,,,,,,,,,,,,EFNA1,EPLG1|LERK1|TNFAIP4,,P20827,,,,,,,,Ephrin-a1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000219,"[""plastron""]",,The ventral part of the shell of a turtle or tortoise.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The ventral part of the shell of a turtle or tortoise.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000219,XPMUser,2013-02-28T12:04:31Z,,,,,BrendaTissueOBO,,BTO:0000219,,,,,,,,,,,,,,,,,,,plastron,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200506,"[""STK3 gene""]",,"This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400317,,,,,,,,"This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200506,,,,,,,,,,,,,,,,6788,STK3,KRS1|MST2,,,,,,,,,,STK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200321,"[""TRPC3 gene""]",,"The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400578,,,,,,,,"The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200321,,,,,,,,,,,,,,,,7222,TRPC3,TRP3,,,,,,,,,,TRPC3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200490,"[""OR1G1 gene""]",,"An olfactory receptor 1G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47890] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47890] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200490,,,,,,,,,,,,,,,,8390,OR1G1,OR1G2,,,,,,,,,,OR1G1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000080,"[""LEU671 in MERTK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000080,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU671 in MERTK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005799,"[""corticotroph adenoma cell""]",,A pituitary adenoma made up predominantly of corticotrophs. Excessive corticotropin secretion may cause Cushings disease or Nelsons syndrome.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001076,,,,,,,,A pituitary adenoma made up predominantly of corticotrophs. Excessive corticotropin secretion may cause Cushings disease or Nelsons syndrome.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005799,Marion,2015-10-16T13:51:44Z,,,,,BrendaTissueOBO,corticotrop adenoma cell|ACTH-secreting adenoma cell|corticotropinoma cell|adrenocorticotropic hormone-secreting adenoma cell,BTO:0005799,,,,,,,,,,,,,,,,,,,corticotroph adenoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000064,"[""CAMK2B kinase domain""]",,Calcium/calmodulin-dependent protein kinase II beta; CAM2; CAMK2; CAMK2B; CAMKB; MGC29528,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Calcium/calmodulin-dependent protein kinase II beta; CAM2; CAMK2; CAMK2B; CAMKB; MGC29528,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000064,,,,,,,,,,,,,,,,,,,200064,,,,,,,,,CAMK2B kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_61,"[""mitral valve disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4079,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:61,,,DOID:59|DOID:58|DOID:11505,UMLS_CUI:C0026265|SNOMEDCT_US_2016_03_01:155279004|ICD10CM:I05.1|SNOMEDCT_US_2016_03_01:11851006|SNOMEDCT_US_2016_03_01:194729004|SNOMEDCT_US_2016_03_01:194724009|ICD10CM:I05.9|SNOMEDCT_US_2016_03_01:250998008|ICD9CM:394.1|ICD9CM:394|SNOMEDCT_US_2016_03_01:194982000|SNOMEDCT_US_2016_03_01:266279005|ICD9CM:424.0|SNOMEDCT_US_2016_03_01:83898004|SNOMEDCT_US_2016_03_01:266278002|SNOMEDCT_US_2016_03_01:155276006|SNOMEDCT_US_2016_03_01:155278007|UMLS_CUI:C0264765|ICD10CM:I05|SNOMEDCT_US_2016_03_01:31085000|NCI:C78446|UMLS_CUI:C0155563,rheumatic disease of mitral valve|Rheumatic mitral valve regurgitation|Rheumatic mitral insufficiency|disease of mitral valve|Rheumatic mitral valve changes|Rheumatic disease of mitral valve (disorder)|rheumatic mitral valve incompetence|Mitral RH valve dis.|chronic rheumatic mitral valve (disorder),,disease_ontology,,DOID:61,,,,,,,,,,,,,,,,,,,mitral valve disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_614,"[""lymphopenia""]",,A leukopenia that is the condition of having an abnormally low level of lymphocytes in the blood.,false,,,http://purl.obolibrary.org/obo/DOID_615,,,,,,,,A leukopenia that is the condition of having an abnormally low level of lymphocytes in the blood.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:614,,,,UMLS_CUI:C0024312|MESH:D008231|ICD9CM:288.51|ICD10CM:D72.810|SNOMEDCT_US_2016_03_01:48813009,Lymphocytopenia,,disease_ontology,,DOID:614,,,,,,,,,,,,,,,,,,,lymphopenia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_615,"[""leukopenia""]",,"A leukocyte disorder that is a decrease in the number of white blood cells (leukocytes) found in the blood, which places individuals at increased risk of infection.",false,,,http://purl.obolibrary.org/obo/DOID_9500,,,,,,,,"A leukocyte disorder that is a decrease in the number of white blood cells (leukocytes) found in the blood, which places individuals at increased risk of infection.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:615,,,,SNOMEDCT_US_2016_03_01:142917003|SNOMEDCT_US_2016_03_01:84828003|ICD10CM:D72.819|MESH:D007970|ICD9CM:288.50|SNOMEDCT_US_2016_03_01:191348003|UMLS_CUI:C0023530,Leucopenia,,disease_ontology,,DOID:615,,,,,,,,,,,,,,,,,,,leukopenia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_612,"[""primary immunodeficiency disease""]",,An immune system disease that results when one or more essential parts of the immune system is missing or not working properly at birth due to a genetic mutation.,false,,,http://purl.obolibrary.org/obo/DOID_2914,,,,,,,,An immune system disease that results when one or more essential parts of the immune system is missing or not working properly at birth due to a genetic mutation.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:612,,,,OMIM:242850|NCI:C39725|KEGG:05340|NCI:C3131|SNOMEDCT_US_2016_03_01:234532001|ICD10CM:D84.9|ICD9CM:279.3|UMLS_CUI:C0021051|SNOMEDCT_US_2016_03_01:64431000|SNOMEDCT_US_2016_03_01:191005003|MESH:D007153,hypoimmunity|immunodeficiency syndrome|immune deficiency disorder,,disease_ontology,,DOID:612,http://purl.obolibrary.org/obo/doid#DO_MGI_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,Xref MGI.,,primary immunodeficiency disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400588,"[""TRPM7 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400483,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400588,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPM7 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200038,"[""CACNA1A gene""]",,"Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to (CAG)n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the (CAG)n-repeats occur in the 3' UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-16 to 21-28 in the coding region is associated with spinocerebellar ataxia 6. [provided by RefSeq, Mar 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400381,,,,,,,,"Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to (CAG)n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the (CAG)n-repeats occur in the 3' UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-16 to 21-28 in the coding region is associated with spinocerebellar ataxia 6. [provided by RefSeq, Mar 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200038,,,,,,,,,,,,,,,,773,CACNA1A,CACH4|CACN3|CACNL1A4,,,,,,,,,,CACNA1A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400548,"[""Kv5.1/KCNF1 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400446,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400548,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv5.1/KCNF1 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5733,"[""salpingitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1962,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5733,,,,ICD10CM:N70.91|SNOMEDCT_US_2016_03_01:266648001|NCI:C26880|UMLS_CUI:C0036130|SNOMEDCT_US_2016_03_01:155968004|SNOMEDCT_US_2016_03_01:198151009|SNOMEDCT_US_2016_03_01:88157006|MESH:D012488,,,disease_ontology,,DOID:5733,,,,,,,,,,,,,,,,,,,salpingitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100485,"[""Tyrosine-protein kinase srms""]",,"A tyrosine-protein kinase Srms that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H3Y6] |tyrosine-protein kinase srms (SRMS)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300132,,,,,,,,"A tyrosine-protein kinase Srms that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H3Y6] |tyrosine-protein kinase srms (SRMS)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100485,,,,https://pharos.nih.gov/idg/targets/Q9H3Y6,,,,,,,,,,,,,SRMS,C20orf148,,Q9H3Y6,,,,,,,,Tyrosine-protein kinase srms,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200278,"[""PKD2L1 gene""]",,"This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400367,,,,,,,,"This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200278,,,,,,,,,,,,,,,,9033,PKD2L1,PKD2L|PKDL|TRPP3,,,,,,,,,,PKD2L1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300347,"[""FAM26 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300347,,,,,,,,,,,,,,,,,,,,,,,,,,,,FAM26 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9849,"[""Meniere's disease""]",,"A vestibular disease characterized by vertigo, low-pitched tinnitus and hearing loss.",false,,,http://purl.obolibrary.org/obo/DOID_9848,,,,,,,,"A vestibular disease characterized by vertigo, low-pitched tinnitus and hearing loss.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9849,,,,UMLS_CUI:C0025281|ICD9CM:386.00|SNOMEDCT_US_2016_03_01:194347007|ICD9CM:386.0|SNOMEDCT_US_2016_03_01:194346003|MESH:D008575|ICD10CM:H81.0|ICD10CM:H81.09|SNOMEDCT_US_2016_03_01:194352002|SNOMEDCT_US_2016_03_01:13445001|SNOMEDCT_US_2016_03_01:155235002|OMIM:156000,Meniere disease|Mnire's vertigo|Otogenic vertigo,,disease_ontology,,DOID:9849,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Meniere's disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100126,"[""Ephrin type-a receptor 2""]",,"ephrin type-a receptor 2 (EPHA2)  with  no mutation  in a nonphosphorylated state|An ephrin type-A receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P29317] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300153,,,,,,,,"ephrin type-a receptor 2 (EPHA2)  with  no mutation  in a nonphosphorylated state|An ephrin type-A receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P29317] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100126,,,,https://pharos.nih.gov/idg/targets/P29317,,,,,,,,,,,,,EPHA2,ECK,,P29317,,,,,,,,Ephrin type-a receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200189,"[""KCNC1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400541,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200189,,,,,,,,,,,,,,,,3746,KCNC1,,,,,,,,,,,KCNC1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060182,"[""microscopic colitis""]",,A colitis that can only be diagnosed_by the examination of colon tissue under a microscope.,false,,,http://purl.obolibrary.org/obo/DOID_0060180,,,,,,,,A colitis that can only be diagnosed_by the examination of colon tissue under a microscope.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060182,emitraka,2014-09-12T14:49:18Z,,SNOMEDCT:235753003|NCI:C38504|SNOMEDCT_US_2016_03_01:235753003|MESH:D046728|ORDO:58220|UMLS_CUI:C0400821,,,disease_ontology,,DOID:0060182,,,,,,,,,,,,,,,,,,,microscopic colitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060181,"[""ischemic colitis""]",,A colitis caused_by inadequate blood supply to the colon.,false,,,http://purl.obolibrary.org/obo/DOID_0060180,,,,,,,,A colitis caused_by inadequate blood supply to the colon.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060181,emitraka,2014-09-12T14:36:51Z,,UMLS_CUI:C0162529|ICD10CM:K55.9|SNOMEDCT_US_2016_03_01:30588004|SNOMEDCT:30588004|MESH:D017091,,,disease_ontology,,DOID:0060181,,,,,,,,,,,,,,,,,,,ischemic colitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060180,"[""colitis""]",,An inflammatory bowel disease that involves inflammation located_in colon.,false,,,http://purl.obolibrary.org/obo/DOID_0050589,,,,,,,,An inflammatory bowel disease that involves inflammation located_in colon.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060180,emitraka,2014-09-12T14:31:45Z,,ICD10CM:K52.9|EFO:0003872|OMIM:191390|NCI:C26723|SNOMEDCT_US_2016_03_01:64226004|UMLS_CUI:C0009319|MESH:D003092|SNOMEDCT:64226004,,,disease_ontology,,DOID:0060180,,,,,,,,,,,,,,,,,,,colitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060184,"[""lymphocytic colitis""]",,A colitis characterized by an accumulation of lymphocytes in the colonic epithelium and connective tissue (lamina propria).,false,,,http://purl.obolibrary.org/obo/DOID_0060182,,,,,,,,A colitis characterized by an accumulation of lymphocytes in the colonic epithelium and connective tissue (lamina propria).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060184,emitraka,2014-09-12T14:58:50Z,,ORDO:65279|MESH:D046730|NCI:C27147|MedDRA:10025268|UMLS_CUI:C0400822|ICD10CM:K52.89|SNOMEDCT_US_2016_03_01:31437008,,,disease_ontology,,DOID:0060184,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,The peak incidence of lymphocytic colitis is in persons over age 50; the disease affects women and men equally.,,lymphocytic colitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060189,"[""ileitis""]",,"An inflammatory bowel disease characterized by inflammation located_in ileum, has_symptom diarrhea, has_symptom abdominal pain, often in the right lower quadrant, has_symptom weight loss.",false,,,http://purl.obolibrary.org/obo/DOID_8778,,,,,,,,"An inflammatory bowel disease characterized by inflammation located_in ileum, has_symptom diarrhea, has_symptom abdominal pain, often in the right lower quadrant, has_symptom weight loss.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060189,emitraka,2014-09-15T11:40:07Z,,ICD10CM:K52.9|NDFRT:N0000001662|CSP:1248-5305|SNOMEDCT_US_2016_03_01:52457000|SNOMEDCT:52457000|MESH:D007079|NCI:C84782|MedDRA:10021312|UMLS_CUI:C0020877,Crohn's ileitis,,disease_ontology,,DOID:0060189,,,,,,,,,,,,,,,,,,,ileitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060185,"[""Clostridium difficile colitis""]",,A colitis characterized by an overgrowth of Clostridium difficile bacteria.,false,,,http://purl.obolibrary.org/obo/DOID_0060180,,,,,,,,A colitis characterized by an overgrowth of Clostridium difficile bacteria.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060185,emitraka,2014-09-12T15:01:17Z,,SNOMEDCT_US_2016_03_01:397696004|MESH:D004761|UMLS_CUI:C0085819|SNOMEDCT_US_2016_03_01:155783000|UMLS_CUI:C0014358|SNOMEDCT_US_2016_03_01:197019008|SNOMEDCT_US_2016_03_01:235752008|UMLS_CUI:C1257845|SNOMEDCT_US_2016_03_01:266525002|UMLS_CUI:C1257844|SNOMEDCT_US_2016_03_01:197124009|UMLS_CUI:C1257843|ICD10CM:A04.7|MedDRA:10009657|SNOMEDCT_US_2016_03_01:51180003|SNOMEDCT_US_2016_03_01:197033008|SNOMEDCT_US_2016_03_01:397683000|SNOMEDCT:423590009,Pseudomembranous colitis,,disease_ontology,,DOID:0060185,,,,,,,,,,,,,,,,,,,Clostridium difficile colitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200312,"[""MERTK gene""]",,"This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400189,,,,,,,,"This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200312,,,,,,,,,,,,,,,,10461,MERTK,MER,,,,,,,,,,MERTK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200318,"[""OR10K2 gene""]",,"An olfactory receptor 10K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF99] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF99] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200318,,,,,,,,,,,,,,,,391107,OR10K2,,,,,,,,,,,OR10K2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100226,"[""Guanylate kinase""]",,"A guanylate kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16774] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391030,,,,,,,,"A guanylate kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16774] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100226,,,,https://pharos.nih.gov/idg/targets/Q16774,,,,,,,,,,,,,GUK1,GMK,,Q16774,,,,,,,,Guanylate kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4939,"[""ureter carcinoma""]",,An ureter cancer that is located_in the ureter.,false,,,http://purl.obolibrary.org/obo/DOID_305|http://purl.obolibrary.org/obo/DOID_11819,,,,,,,,An ureter cancer that is located_in the ureter.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4939,,,,NCI:C8993|UMLS_CUI:C0600079,ureteral carcinoma,,disease_ontology,,DOID:4939,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,ureter carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100124,"[""Glucagon receptor""]",,"A glucagon receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47871] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300047,,,,,,,,"A glucagon receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47871] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100124,,,,https://pharos.nih.gov/idg/targets/P47871,,,,,,,,,,,,,GCGR,,,P47871,,,,,,,,Glucagon receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100592,"[""Inositol hexakisphosphate kinase 1""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100592,,,,,,,,,,,,,,,,,IP6K1,,,Q92551,,,,,,,,Inositol hexakisphosphate kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000948,"[""SKOV-3 cell""]",,Human ovary; metastatic site: ascites adenocarcinoma cell line; established from a 64-year-old caucasian female.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001882,,,,,,,,Human ovary; metastatic site: ascites adenocarcinoma cell line; established from a 64-year-old caucasian female.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000948,,,,,,,BrendaTissueOBO,SKOV3 cell|SK-OV-3 cell,BTO:0000948,,,,,,,,,,,,,,,,,,,SKOV-3 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491043,"[""RIOK1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491037,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491043,,,,,,,,,,,,,,,,,RIOK1,,,,,,,,,,,RIOK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000233,"[""MET97 in CAMK1G""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000233,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET97 in CAMK1G,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000147,"[""MET1947 in LRRK2(G2019S)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000147,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET1947 in LRRK2(G2019S),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000034,"[""ADCK4 kinase domain""]",,AarF domain containing kinase 4; ADCK4; FLJ12229,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,AarF domain containing kinase 4; ADCK4; FLJ12229,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000034,,,,,,,,,,,,,,,,,,,200033,,,,,,,,,ADCK4 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000186,"[""MET523 in PAK7""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000186,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET523 in PAK7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100075,"[""H(+)/cl(-) exchange transporter 4""]",,"An H(+)/Cl(-) exchange transporter 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51793] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300398,,,,,,,,"An H(+)/Cl(-) exchange transporter 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51793] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100075,,,,https://pharos.nih.gov/idg/targets/P51793,,,,,,,,,,,,,CLCN4,,,P51793,,,,,,,,H(+)/cl(-) exchange transporter 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11080,"[""myiasis""]",,A parasitic ectoparasitic infectious disease that is caused by parasitic dipterous fly larvae (maggots) feeding on the host's necrotic or living tissue.,false,,,http://purl.obolibrary.org/obo/DOID_4110,,,,,,,,A parasitic ectoparasitic infectious disease that is caused by parasitic dipterous fly larvae (maggots) feeding on the host's necrotic or living tissue.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11080,,,,SNOMEDCT_US_2016_03_01:60412004|SNOMEDCT_US_2016_03_01:154423006|SNOMEDCT_US_2016_03_01:187547004|SNOMEDCT_US_2016_03_01:266225001|ICD10CM:B87.9|UMLS_CUI:C0027030|ICD10CM:B87|MESH:D009198|SNOMEDCT_US_2016_03_01:187224004|ICD9CM:134.0,"Myiasis, unspecified|Infestation by maggots|Myiasis, unspecified (disorder)|Maggot infestation|Infestation by fly larvae (disorder)",,disease_ontology,,DOID:11080,,,,,,,,,,,,,,,,,,,myiasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400031,"[""Chemokine receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400031,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chemokine receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300495,"[""Alpha-6/CHRNA6 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300495,,,,,,,,,,,,,,,,,,,,,,,,,,,,Alpha-6/CHRNA6 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001193,"[""C-127 cell""]",,Murine mammary tumor line from a female mus musculus.,false,,,http://purl.obolibrary.org/obo/BTO_0004086|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Murine mammary tumor line from a female mus musculus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001193,,,,,,,BrendaTissueOBO,C127cell,BTO:0001193,,,,,,,,,,,,,,,,,,,C-127 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004814,"[""DT-40 cell""]",,"Chicken B cell line; established in 1985 from a bursal lymphoma, which was induced by infection of a 1 day old chicken with Rous-associated virus type 1 (RAV-1), an avian leukosis retrovirus carrying no cell-derived oncogene.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001522|http://purl.obolibrary.org/obo/BTO_0001518,,,,,,,,"Chicken B cell line; established in 1985 from a bursal lymphoma, which was induced by infection of a 1 day old chicken with Rous-associated virus type 1 (RAV-1), an avian leukosis retrovirus carrying no cell-derived oncogene.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004814,mgr,2010-10-05T11:47:40Z,,,,,BrendaTissueOBO,DT-40B cell|DT40B cell|DT40 cell|DT 40 cell,BTO:0004814,,,,,,,,,,,,,,,,,,,DT-40 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004508,"[""endothelioma cell""]",,A tumor developing from endothelial tissue.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A tumor developing from endothelial tissue.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004508,mgr,2010-02-08T04:41:49Z,,,,,BrendaTissueOBO,,BTO:0004508,,,,,,,,,,,,,,,,,,,endothelioma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400105,"[""CAMK group gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400102,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400105,,,,,,,,,,,,,,,,,,,,,,,,,,,,CAMK group gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200178,"[""KCNMB3 gene""]",,"MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. [provided by RefSeq, Jul 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400440,,,,,,,,"MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. [provided by RefSeq, Jul 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200178,,,,,,,,,,,,,,,,27094,KCNMB3,KCNMB2|KCNMBL,,,,,,,,,,KCNMB3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2519,"[""testicular disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_48,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2519,,,,SNOMEDCT_US_2016_03_01:64910008|SNOMEDCT_US_2016_03_01:236763001|MESH:D013733|NCI:C26890|UMLS_CUI:C0039584|SNOMEDCT_US_2016_03_01:297228003,disorder of testis|testis disorder,,disease_ontology,,DOID:2519,,,,,,,,,,,,,,,,,,,testicular disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100211,"[""Potassium voltage-gated channel subfamily H member 7""]",,"A voltage-gated potassium channel KCNH7 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9NS40] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300559,,,,,,,,"A voltage-gated potassium channel KCNH7 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9NS40] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100211,,,,https://pharos.nih.gov/idg/targets/Q9NS40,,,,,,,,,,,,,KCNH7,ERG3,,Q9NS40,,,,,,,,Potassium voltage-gated channel subfamily H member 7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200480,"[""OR1C1 gene""]",,"An olfactory receptor 1C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15619] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15619] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200480,,,,,,,,,,,,,,,,26188,OR1C1,,,,,,,,,,,OR1C1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300069,"[""Neuropeptide FF/neuropeptide AF receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300069,,,,,,,,,,,,,,,,,,,,,,,,,,,,Neuropeptide FF/neuropeptide AF receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100193,"[""G-protein coupled receptor 35""]",,"A G-protein coupled receptor 35 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HC97] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 35 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HC97] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100193,,,,https://pharos.nih.gov/idg/targets/Q9HC97,,,,,,,,,,,,,GPR35,,,Q9HC97,,,,,,,,G-protein coupled receptor 35,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000188,"[""colonic cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000003,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000188,,,,,,,BrendaTissueOBO,,BTO:0000188,,,,,,,,,,,,,,,,,,,colonic cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000094,"[""CSF1R kinase domain""]",,Colony stimulating factor 1 receptor; CD115; C-FMS; CSF1R; CSF-1R; CSF-1-R; CSFR; FIM2; FIM-2; FMS; Fms/CSFR,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Colony stimulating factor 1 receptor; CD115; C-FMS; CSF1R; CSF-1R; CSF-1-R; CSFR; FIM2; FIM-2; FMS; Fms/CSFR,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000094,,,,,,,,,,,,,,,,,,,200094,,,,,,,,,CSF1R kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01390006,"[""Voltage-gated ion channel""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01390006,,,,,,,,,,,,,,,,,,,,,,,,,,,,Voltage-gated ion channel,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004213,"[""SF-295 cell""]",,Human glioblastoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001530,,,,,,,,Human glioblastoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004213,,,,,,,BrendaTissueOBO,SF295 cell,BTO:0004213,,,,,,,,,,,,,,,,,,,SF-295 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400214,"[""CCK4 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400214,,,,,,,,,,,,,,,,,,,,,,,,,,,,CCK4 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000312,"[""NEK2 kinase domain""]",,Serine/threonine-protein kinase Nek2; NIMA (never in mitosis gene a)-related kinase 2; HsPK21; NEK2; NEK2A; NLK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase Nek2; NIMA (never in mitosis gene a)-related kinase 2; HsPK21; NEK2; NEK2A; NLK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000312,,,,,,,,,,,,,,,,,,,200288,,,,,,,,,NEK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200128,"[""GPR107 gene""]",,"A protein GPR107 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5VW38] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400051,,,,,,,,"A protein GPR107 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5VW38] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200128,,,,,,,,,,,,,,,,57720,GPR107,KIAA1624|LUSTR1,,,,,,,,,,GPR107 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_50277,"[""Farnesyl diphosphate""]","VWFJDQUYCIWHTN-UHFFFAOYSA-N|C15H28O7P2|farnesyl diphosphates|CC(C)=CCCC(C)=CCCC(C)=CCOP(O)(=O)OP(O)(O)=O|
InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)
",A farnesyl phosphate that has formula C15H28O7P2.,false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,DrugBank:DB07780|Beilstein:1892961|NIST Chemistry WebBook:13058-04-3,A farnesyl phosphate that has formula C15H28O7P2.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:24016|CHEBI:14231,,"
3,7,11-trimethyldodeca-2,6,10-trien-1-yl trihydrogen diphosphate
|farnesyl diphosphate",,chebi_ontology,"VWFJDQUYCIWHTN-UHFFFAOYSA-N|C15H28O7P2|farnesyl diphosphates|CC(C)=CCCC(C)=CCCC(C)=CCOP(O)(=O)OP(O)(O)=O|
InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)
",,,CHEBI:50277,,,,,,,,,,,,,,,,,,,,,,,CHEBI:50277,,,,,farnesyl diphosphate|Farnesyl diphosphate,,CHEBI:50277,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200418,"[""PIM2 gene""]",,"This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400207,,,,,,,,"This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200418,,,,,,,,,,,,,,,,11040,PIM2,,,,,,,,,,,PIM2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_89666,"[""Angiotensin III""]","InChI=1S/C46H66N12O9/c1-5-27(4)38(57-40(61)33(21-29-15-17-31(59)18-16-29)53-42(63)37(26(2)3)56-39(60)32(47)13-9-19-51-46(48)49)43(64)54-34(23-30-24-50-25-52-30)44(65)58-20-10-14-36(58)41(62)55-35(45(66)67)22-28-11-7-6-8-12-28/h6-8,11-12,15-18,24-27,32-38,59H,5,9-10,13-14,19-23,47H2,1-4H3,(H,50,52)(H,53,63)(H,54,64)(H,55,62)(H,56,60)(H,57,61)(H,66,67)(H4,48,49,51)/t27-,32-,33-,34-,35-,36-,37-,38-/m0/s1|930.508|C46H66N12O9|Des-Asp-1-Angiotensin II|931.093|O=C(N1[C@@H](CCC1)C(=O)N[C@@H](CC2=CC=CC=C2)C(O)=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CCCN=C(N)N)C(C)C)CC3=CC=C(O)C=C3)[C@H](CC)C)CC=4NC=NC4|QMMRCKSBBNJCMR-KMZPNFOHSA-N|0",,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,PMID:3893156|PMID:9857379|PMID:2197067|HMDB:HMDB01036|PMID:12584663|PMID:7850406|PMID:9370053|PMID:10778144|PMID:12609766|PMID:15529593|PMID:8170622|CAS:12687-51-3|PMID:17094048|PMID:190880|PMID:11295571|PMID:8923799|PMID:8574286|Wikipedia:Angiotensin_III|PMID:16842210|PMID:14996614|PMID:15894523|PMID:17210474|PMID:11751722|PMID:9537002|PMID:6324655|PMID:6088844|PMID:12428219|PMID:6183092|PMID:3284361|PMID:15748538|PMID:9655649|PMID:6316802|PMID:16149578,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,"(2S)-2-{[(2S)-1-[(2S)-2-[(2S,3S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-5-[(diaminomethylidene)amino]pentanamido]-3-methylbutanamido]-3-(4-hydroxyphenyl)propanamido]-3-methylpentanamido]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanoic acid",,chebi_ontology,"InChI=1S/C46H66N12O9/c1-5-27(4)38(57-40(61)33(21-29-15-17-31(59)18-16-29)53-42(63)37(26(2)3)56-39(60)32(47)13-9-19-51-46(48)49)43(64)54-34(23-30-24-50-25-52-30)44(65)58-20-10-14-36(58)41(62)55-35(45(66)67)22-28-11-7-6-8-12-28/h6-8,11-12,15-18,24-27,32-38,59H,5,9-10,13-14,19-23,47H2,1-4H3,(H,50,52)(H,53,63)(H,54,64)(H,55,62)(H,56,60)(H,57,61)(H,66,67)(H4,48,49,51)/t27-,32-,33-,34-,35-,36-,37-,38-/m0/s1|930.508|C46H66N12O9|Des-Asp-1-Angiotensin II|931.093|O=C(N1[C@@H](CCC1)C(=O)N[C@@H](CC2=CC=CC=C2)C(O)=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CCCN=C(N)N)C(C)C)CC3=CC=C(O)C=C3)[C@H](CC)C)CC=4NC=NC4|QMMRCKSBBNJCMR-KMZPNFOHSA-N|0",,,CHEBI:89666,,,,,,,,,,,,,,,,,,,,,,,CHEBI:89666,,,,,Angiotensin III,,CHEBI:89666,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100077,"[""C-x-c chemokine receptor type 3""]",,"A C-X-C chemokine receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49682] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300097,,,,,,,,"A C-X-C chemokine receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49682] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100077,,,,https://pharos.nih.gov/idg/targets/P49682,,,,,,,,,,,,,CXCR3,GPR9,,P49682,,,,,,,,C-x-c chemokine receptor type 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8956,"[""cowpox""]",,"A viral infectious disease that results_in infection in rodents, cows, and humans, located_in skin, has_material_basis_in Cowpox virus, which is transmitted_by contact with an infected animal. The infection results_in_formation_of vesicopustular lesions on the hands or face.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in infection in rodents, cows, and humans, located_in skin, has_material_basis_in Cowpox virus, which is transmitted_by contact with an infected animal. The infection results_in_formation_of vesicopustular lesions on the hands or face.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8956,,,,SNOMEDCT_US_2016_03_01:154344005|ICD9CM:051.01|ICD10CM:B08.010|SNOMEDCT_US_2016_03_01:266193008|MESH:D015605|UMLS_CUI:C0010232|SNOMEDCT_US_2016_03_01:70090004,yaba,,disease_ontology,,DOID:8956,http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,cowpox,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003023,"[""NCI-H510 cell""]",,Small cell lung cancer cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002206,,,,,,,,Small cell lung cancer cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003023,,,,,,,BrendaTissueOBO,H510 cell|H-510 cell,BTO:0003023,,,,,,,,,,,,,,,,,,,NCI-H510 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9477,"[""pulmonary embolism""]",,"An artery disease characterized by a blockage of the main artery of the lung or one of its branches by a substance that has travelled from elsewhere in the body, e.g. a blood clot.",false,,,http://purl.obolibrary.org/obo/DOID_0050828,,,,,,,,"An artery disease characterized by a blockage of the main artery of the lung or one of its branches by a substance that has travelled from elsewhere in the body, e.g. a blood clot.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9477,,,,SNOMEDCT_US_2016_03_01:194882001|ICD10CM:I26.99|SNOMEDCT_US_2016_03_01:155326007|ICD10CM:I26|UMLS_CUI:C0034065|SNOMEDCT_US_2016_03_01:266292008|NCI:C50713|MESH:D011655|SNOMEDCT_US_2016_03_01:59282003,pulmonary artery embolism|pulmonary embolus,,disease_ontology,,DOID:9477,,,,,,,,,,,,,,,,,PRISM.,,pulmonary embolism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001233,"[""plant embryo""]",,"The early developmental stage that, through embryological development, ultimately becomes an adult individual. In plants, that portion of a seed that will form the growing seedling following germination, it has a radicle, apical meristem, and embryonic leaf or leaves.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001461,,,,,,,,"The early developmental stage that, through embryological development, ultimately becomes an adult individual. In plants, that portion of a seed that will form the growing seedling following germination, it has a radicle, apical meristem, and embryonic leaf or leaves.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001233,,,,,,,BrendaTissueOBO,embryo|plant germ,BTO:0001233,,,,,,,,,,,,,,,,,,,plant embryo,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5716,"[""hormone producing pituitary cancer""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1785,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5716,,,DOID:6254,NCI:C7911|UMLS_CUI:C0278864|UMLS_CUI:C0851693|NCI:C7047,"Pituitary tumors, Hormone Producing|growth hormone producing pituitary tumor|Somatotropinoma",,disease_ontology,,DOID:5716,,,,,,,,,,,,,,,,,,,hormone producing pituitary cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001180,"[""idioblast""]",,A plant cell committed to develop into a cell type that differs from the surrounding tissue.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A plant cell committed to develop into a cell type that differs from the surrounding tissue.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001180,,,,,,,BrendaTissueOBO,,BTO:0001180,,,,,,,,,,,,,,,,,,,idioblast,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200474,"[""OPN1MW; OPN1MW2 gene""]",,A medium-wave-sensitive opsin 1 that is encoded in the genome of human. [PRO:WCB] ,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,A medium-wave-sensitive opsin 1 that is encoded in the genome of human. [PRO:WCB] ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200474,,,,,,,,,,,,,,,,101060233|2652|728458,OPN1MW,GCP|OPN1MW2,,,,,,,,,,OPN1MW; OPN1MW2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100523,"[""Olfactory receptor 2f2""]",,"An olfactory receptor 2F2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95006] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2F2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95006] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100523,,,,https://pharos.nih.gov/idg/targets/O95006,,,,,,,,,,,,,OR2F2,,,O95006,,,,,,,,Olfactory receptor 2f2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200589,"[""ITPKC gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200589,,,,,,,,,,,,,,,,,,,,,,,,,,,,ITPKC gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200236,"[""KCNQ5 gene""]",,"This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400565,,,,,,,,"This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200236,,,,,,,,,,,,,,,,56479,KCNQ5,,,,,,,,,,,KCNQ5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200530,"[""TNNI3K gene""]",,"This gene encodes a protein that belongs to the MAP kinase kinase kinase (MAPKKK) family of protein kinases. The protein contains ankyrin repeat, protein kinase and serine-rich domains and is thought to play a role in cardiac physiology. [provided by RefSeq, Sep 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400320,,,,,,,,"This gene encodes a protein that belongs to the MAP kinase kinase kinase (MAPKKK) family of protein kinases. The protein contains ankyrin repeat, protein kinase and serine-rich domains and is thought to play a role in cardiac physiology. [provided by RefSeq, Sep 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200530,,,,,,,,,,,,,,,,100526835|51086,TNNI3K,CARK,,,,,,,,,,TNNI3K gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000425,"[""VAL751 in EPHA6""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000425,,,,,,,,,,,,,,,,,,,,,,,,,,,,VAL751 in EPHA6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004716,"[""null cell""]",,"A null cell is a large granular lymphocyte without surface markers or membrane-associated proteins from B lymphocytes or T lymphocytes. Members of null cells are natural killer cells, antigen dependent cytotoxic cells and the lymphokine activated killer cells.",false,,,http://purl.obolibrary.org/obo/BTO_0000775|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A null cell is a large granular lymphocyte without surface markers or membrane-associated proteins from B lymphocytes or T lymphocytes. Members of null cells are natural killer cells, antigen dependent cytotoxic cells and the lymphokine activated killer cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004716,mgr,2010-05-18T11:33:17Z,,,,,BrendaTissueOBO,,BTO:0004716,,,,,,,,,,,,,,,,,,,null cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100324,"[""Olfactory receptor 10V1""]",,"An olfactory receptor 10V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100324,,,,https://pharos.nih.gov/idg/targets/Q8NGI7,,,,,,,,,,,,,OR10V1,,,Q8NGI7,,,,,,,,Olfactory receptor 10V1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000100,"[""astrocytoma cell""]",,"A tumor cell composed of astrocytes; it is the most common type of primary brain tumor and is also found throughout the central nervous system. One classification groups astrocytomas according to their histologic appearance and distinguishes pilocytic, protoplasmic, gemistocytic, and fibrillary types. Another classification groups them in order of increasing malignancy as Grade I, Grade II, Grade III, and Grade IV types.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000526,,,,,,,,"A tumor cell composed of astrocytes; it is the most common type of primary brain tumor and is also found throughout the central nervous system. One classification groups astrocytomas according to their histologic appearance and distinguishes pilocytic, protoplasmic, gemistocytic, and fibrillary types. Another classification groups them in order of increasing malignancy as Grade I, Grade II, Grade III, and Grade IV types.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000100,,,,,,,BrendaTissueOBO,astroglial tumor cell|astroglial neoplasm cell|astrocytic glioma cell|astroglioma cell,BTO:0000100,,,,,,,,,,,,,,,,,,,astrocytoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300286,"[""TAK1 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300165,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300286,,,,,,,,,,,,,,,,,,,,,,,,,,,,TAK1 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200414,"[""OR52D1 gene""]",,"An olfactory receptor 52D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H346] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 52D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H346] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200414,,,,,,,,,,,,,,,,390066,OR52D1,,,,,,,,,,,OR52D1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_422,"[""congenital structural myopathy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_423,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:422,,,,UMLS_CUI:C0752282|NCI:C84648|MESH:D020914,,,disease_ontology,,DOID:422,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,congenital structural myopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_423,"[""myopathy""]",,A muscular disease in which the muscle fibers do not function resulting in muscular weakness.,false,,,http://purl.obolibrary.org/obo/DOID_66,,,,,,,,A muscular disease in which the muscle fibers do not function resulting in muscular weakness.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:423,,,,SNOMEDCT_US_2016_03_01:267711006|SNOMEDCT_US_2016_03_01:52794005|SNOMEDCT_US_2016_03_01:75047002|UMLS_CUI:C0026848|NCI:C101216|SNOMEDCT_US_2016_03_01:203845002|SNOMEDCT_US_2016_03_01:155099000|SNOMEDCT_US_2016_03_01:155094005|SNOMEDCT_US_2016_03_01:129565002|ICD10CM:G72.9|ICD10CM:M60-M63|MESH:D009135|SNOMEDCT_US_2016_03_01:268103006|ICD10CM:M62.9|SNOMEDCT_US_2016_03_01:203833006|ICD9CM:359.9|SNOMEDCT_US_2016_03_01:267714003,,,disease_ontology,,DOID:423,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,myopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_421,"[""hair disease""]",,An integumentary system disease that is located_in hair.,false,,,http://purl.obolibrary.org/obo/DOID_16,,,,,,,,An integumentary system disease that is located_in hair.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:421,,,,SNOMEDCT_US_2016_03_01:156407009|UMLS_CUI:C0018500|SNOMEDCT_US_2016_03_01:267862002|SNOMEDCT_US_2016_03_01:279425004|NCI:C34656|MESH:D006201,,,disease_ontology,,DOID:421,,,,,,,,,,,,,,,,,,,hair disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_424,"[""pulmonary immaturity""]",,,false,,,http://purl.obolibrary.org/obo/DOID_850,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:424,,,,ICD9CM:770.4|ICD10CM:P28.0|UMLS_CUI:C0270163|SNOMEDCT_US_2016_03_01:42908004|SNOMEDCT_US_2016_03_01:123275009,"primary atelectasis, in perinatal period|primary atelectasis of newborn",,disease_ontology,,DOID:424,,,,,,,,,,,,,,,,,,,pulmonary immaturity,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_420,"[""hypertrichosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_421,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:420,,,,SNOMEDCT_US_2016_03_01:201164001|MESH:D006983|ICD10CM:L68|ICD10CM:L68.9|SNOMEDCT_US_2016_03_01:40090008|SNOMEDCT_US_2016_03_01:201165000|UMLS_CUI:C0020555|NCI:C79597|SNOMEDCT_US_2016_03_01:156409007|ICD10CM:L68.3|SNOMEDCT_US_2016_03_01:29966009|SNOMEDCT_US_2016_03_01:271607001,,,disease_ontology,,DOID:420,,,,,,,,,,,,,,,,,,,hypertrichosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200182,"[""GPR1 gene""]",,"A G-protein coupled receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46091] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46091] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200182,,,,,,,,,,,,,,,,2825,GPR1,,,,,,,,,,,GPR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004129,"[""ovary epithelium cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0000977|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004129,,,,,,,BrendaTissueOBO,ovarian epithelial cell line,BTO:0004129,,,,,,,,,,,,,,,,,,,ovary epithelium cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001713,"[""dorsum""]",,The back; especially : the entire dorsal surface of an animal.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The back; especially : the entire dorsal surface of an animal.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001713,,,,,,,BrendaTissueOBO,back,BTO:0001713,,,,,,,,,,,,,,,,,,,dorsum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300518,"[""GABRG2 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300518,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRG2 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200378,"[""OR4A47 gene""]",,"An olfactory receptor 4A47 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF82] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4A47 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF82] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200378,,,,,,,,,,,,,,,,403253,OR4A47,,,,,,,,,,,OR4A47 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400306,"[""PDHK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400131,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400306,,,,,,,,,,,,,,,,,,,,,,,,,,,,PDHK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100236,"[""Leucine-rich repeat-containing G-protein coupled receptor 5""]",,"A leucine-rich repeat-containing G-protein coupled receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O75473] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A leucine-rich repeat-containing G-protein coupled receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O75473] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100236,,,,https://pharos.nih.gov/idg/targets/O75473,,,,,,,,,,,,,LGR5,GPR49|GPR67,,O75473,,,,,,,,Leucine-rich repeat-containing G-protein coupled receptor 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100626,"[""Olfactory receptor 5h2""]",,"An olfactory receptor 5H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGV7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGV7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100626,,,,https://pharos.nih.gov/idg/targets/Q8NGV7,,,,,,,,,,,,,OR5H2,,,Q8NGV7,,,,,,,,Olfactory receptor 5h2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400530,"[""Kv1.8/KCNA10 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400436,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400530,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv1.8/KCNA10 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1073,"[""renal hypertension""]",,,false,,,http://purl.obolibrary.org/obo/DOID_557|http://purl.obolibrary.org/obo/DOID_11130,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1073,,,,SNOMEDCT_US_2016_03_01:194775007|UMLS_CUI:C0020544|NCI:C3121|MESH:D006977|SNOMEDCT_US_2016_03_01:28119000,,,disease_ontology,,DOID:1073,,,,,,,,,,,,,,,,,,,renal hypertension,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300232,"[""TBCK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300232,,,,,,,,,,,,,,,,,,,,,,,,,,,,TBCK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3742,"[""bladder squamous cell carcinoma""]",,A carcinoma of bladder that is manifested in squamous cells of the bladder.,false,,,http://purl.obolibrary.org/obo/DOID_1749|http://purl.obolibrary.org/obo/DOID_4007,,,,,,,,A carcinoma of bladder that is manifested in squamous cells of the bladder.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3742,,,,SNOMEDCT_US_2016_03_01:255111004|UMLS_CUI:C0279681|NCI:C4031,Epidermoid carcinoma of the urinary bladder|squamous cell carcinoma of bladder (disorder),,disease_ontology,,DOID:3742,,,,,,,,,,,,,,,,,,,bladder squamous cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3331,"[""frontal lobe epilepsy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2234,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3331,,,,MESH:D017034|UMLS_CUI:C0085541|SNOMEDCT_US_2016_03_01:230394006,Frontal lobe epilepsy (disorder),,disease_ontology,,DOID:3331,,,,,,,,,,,,,,,,,,,frontal lobe epilepsy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491023,"[""Thiamine pyrophosphokinase family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400324,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491023,,,,,,,,,,,,,,,,,,,,,,,,,,,,Thiamine pyrophosphokinase family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100259,"[""Glutamate receptor ionotropic, nmda 2c""]",,"A glutamate receptor ionotropic, NMDA 2C that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14957] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300457,,,,,,,,"A glutamate receptor ionotropic, NMDA 2C that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14957] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100259,,,,https://pharos.nih.gov/idg/targets/Q14957,,,,,,,,,,,,,GRIN2C,NMDAR2C,,Q14957,,,,,,,,"Glutamate receptor ionotropic, nmda 2c",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5062,"[""phencyclidine abuse""]",,A substance abuse that involves the recurring use of phencyclidine (PCP) drugs despite negative consequences.,false,,,http://purl.obolibrary.org/obo/DOID_302,,,,,,,,A substance abuse that involves the recurring use of phencyclidine (PCP) drugs despite negative consequences.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5062,,,,MESH:D010623|UMLS_CUI:C0031391|SNOMEDCT_US_2016_03_01:7071007,PCP abuse|Phencyclidine abuse,,disease_ontology,,DOID:5062,,,,,,,,,,,,,,,,,,,phencyclidine abuse,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400066,"[""Tachykinin receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400066,,,,,,,,,,,,,,,,,,,,,,,,,,,,Tachykinin receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9467,"[""nail-patella syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9467,,,,ICD10CM:Q87.2|MESH:D009261|SNOMEDCT_US_2016_03_01:22199006|OMIM:161200|NCI:C75120|UMLS_CUI:C0027341,Turner-Kiser syndrome|iliac horn syndrome|hereditary onychoostedysplasia|nail patella syndrome|Fong disease,,disease_ontology,,DOID:9467,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,nail-patella syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000634,"[""integument""]",,"Something that covers or encloses; especially: an enveloping layer (as a skin, membrane, or husk) of an organism or one of its parts.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Something that covers or encloses; especially: an enveloping layer (as a skin, membrane, or husk) of an organism or one of its parts.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000634,,,,,,,BrendaTissueOBO,tegument|Hautsystem|dermal system|dermoid system|integumentary system|integumental system,BTO:0000634,,,,,,,,,,,,,,,,,,,integument,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400443,"[""C (Shaw) subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400443,,,,,,,,,,,,,,,,,,,,,,,,,,,,C (Shaw) subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_6603,"[""Lypressin""]","1055.432|BJFIDCADFRDPIO-UHFFFAOYSA-N|8-L-Lysine vasopressin|C46H65N13O12S2|InChI=1S/C46H65N13O12S2/c47-17-5-4-9-29(40(65)52-22-38(51)63)54-45(70)35-10-6-18-59(35)46(71)34-24-73-72-23-28(48)39(64)55-31(20-26-11-13-27(60)14-12-26)43(68)56-32(19-25-7-2-1-3-8-25)42(67)53-30(15-16-36(49)61)41(66)57-33(21-37(50)62)44(69)58-34/h1-3,7-8,11-14,28-35,60H,4-6,9-10,15-24,47-48H2,(H2,49,61)(H2,50,62)(H2,51,63)(H,52,65)(H,53,67)(H,54,70)(H,55,64)(H,56,68)(H,57,66)(H,58,69)|LVP|NCCCCC(NC(=O)C1CCCN1C(=O)C1CSSCC(N)C(=O)NC(Cc2ccc(O)cc2)C(=O)NC(Cc2ccccc2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(N)=O)C(=O)N1)C(=O)NCC(N)=O|0|DIAPID (TN)|1056.222",,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,CAS:50-57-7|KEGG:D00366|KEGG:C07105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Lypressin,,chebi_ontology,"1055.432|BJFIDCADFRDPIO-UHFFFAOYSA-N|8-L-Lysine vasopressin|C46H65N13O12S2|InChI=1S/C46H65N13O12S2/c47-17-5-4-9-29(40(65)52-22-38(51)63)54-45(70)35-10-6-18-59(35)46(71)34-24-73-72-23-28(48)39(64)55-31(20-26-11-13-27(60)14-12-26)43(68)56-32(19-25-7-2-1-3-8-25)42(67)53-30(15-16-36(49)61)41(66)57-33(21-37(50)62)44(69)58-34/h1-3,7-8,11-14,28-35,60H,4-6,9-10,15-24,47-48H2,(H2,49,61)(H2,50,62)(H2,51,63)(H,52,65)(H,53,67)(H,54,70)(H,55,64)(H,56,68)(H,57,66)(H,58,69)|LVP|NCCCCC(NC(=O)C1CCCN1C(=O)C1CSSCC(N)C(=O)NC(Cc2ccc(O)cc2)C(=O)NC(Cc2ccccc2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(N)=O)C(=O)N1)C(=O)NCC(N)=O|0|DIAPID (TN)|1056.222",,,CHEBI:6603,,,,,,,,,,,,,,,,,,,,,,,CHEBI:6603,,,,,Lypressin,,CHEBI:6603,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200282,"[""NPY2R gene""]",,"A neuropeptide Y receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49146] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400071,,,,,,,,"A neuropeptide Y receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49146] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200282,,,,,,,,,,,,,,,,4887,NPY2R,,,,,,,,,,,NPY2R gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400576,"[""MCOLN3 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400452,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400576,,,,,,,,,,,,,,,,,,,,,,,,,,,,MCOLN3 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8504,"[""impetigo""]",,"A pyoderma consisting of three forms of skin lesions having either a thick, adherent, recurrent, dirty yellow crust with an erythematous margin (common or superficial impetigo) or lessions which are superficial, thin-walled, and bullous as found in bullous impetigo. The lesions in bullous (staphylococcal) impetigo, which are always caused by S aureus, are superficial, thin-walled, and bullous.",false,,,http://purl.obolibrary.org/obo/DOID_4223,,,,,,,,"A pyoderma consisting of three forms of skin lesions having either a thick, adherent, recurrent, dirty yellow crust with an erythematous margin (common or superficial impetigo) or lessions which are superficial, thin-walled, and bullous as found in bullous impetigo. The lesions in bullous (staphylococcal) impetigo, which are always caused by S aureus, are superficial, thin-walled, and bullous.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8504,,,,UMLS_CUI:C0021099|SNOMEDCT_US_2016_03_01:48277006|MESH:D007169|ICD9CM:684|ICD10CM:L01.00|NCI:C99088|ICD10CM:L01|ICD10CM:L01.0|SNOMEDCT_US_2016_03_01:156319000|SNOMEDCT_US_2016_03_01:200710001|SNOMEDCT_US_2016_03_01:267836006,,,disease_ontology,,DOID:8504,http://purl.obolibrary.org/obo/doid#gram-positive_bacterial_infectious_disease,,,,,,,,,,,,,,,,,,impetigo,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100053,"[""Calcium homeostasis modulator protein 2""]",,"A calcium homeostasis modulator protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HA72] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300335,,,,,,,,"A calcium homeostasis modulator protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HA72] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100053,,,,https://pharos.nih.gov/idg/targets/Q9HA72,,,,,,,,,,,,,CALHM2,FAM26B,,Q9HA72,,,,,,,,Calcium homeostasis modulator protein 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000110,"[""DCLK1 kinase domain""]",,Serine/threonine-protein kinase DCLK1; CL1; CLICK1; DCAMKL1; DCDC3A; DCLK; DCLK1; KIAA0369,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase DCLK1; CL1; CLICK1; DCAMKL1; DCDC3A; DCLK; DCLK1; KIAA0369,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000110,,,,,,,,,,,,,,,,,,,200109,,,,,,,,,DCLK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000253,"[""MAP3K15 kinase domain""]",,Mitogen-activated protein kinase kinase kinase 15; bA723P2.3; FLJ16518; MAP3K15; MAP3K7,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase kinase kinase 15; bA723P2.3; FLJ16518; MAP3K15; MAP3K7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000253,,,,,,,,,,,,,,,,,,,200236,,,,,,,,,MAP3K15 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200007,"[""CHRNA2 gene""]",,"Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. [provided by RefSeq, Nov 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400491,,,,,,,,"Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. [provided by RefSeq, Nov 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200007,,,,,,,,,,,,,,,,1135,CHRNA2,,,,,,,,,,,CHRNA2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100143,"[""Adhesion G-protein coupled receptor D1""]",,"A G-protein coupled receptor 133 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6QNK2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,"A G-protein coupled receptor 133 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6QNK2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100143,,,,https://pharos.nih.gov/idg/targets/Q6QNK2,,,,,,,,,,,,,GPR133,ADGRD1|PGR25,,Q6QNK2,,,,,,,,Adhesion G-protein coupled receptor D1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2537,"[""inflammatory and toxic neuropathy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_870,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2537,,,,SNOMEDCT_US_2016_03_01:155060008|SNOMEDCT_US_2016_03_01:193172009|SNOMEDCT_US_2016_03_01:267603007|ICD9CM:357.9|SNOMEDCT_US_2016_03_01:267601009|ICD9CM:357|UMLS_CUI:C0154758|SNOMEDCT_US_2016_03_01:193204000,,,disease_ontology,,DOID:2537,,,,,,,,,,,,,,,,,,,inflammatory and toxic neuropathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001558,"[""somite""]",,"A segmental mass of mesoderm in the vertebrate embryo, occurring in pairs along the notochord and developing into muscles and vertebrae.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A segmental mass of mesoderm in the vertebrate embryo, occurring in pairs along the notochord and developing into muscles and vertebrae.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001558,,,,,,,BrendaTissueOBO,,BTO:0001558,,,,,,,,,,,,,,,,,,,somite,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000161,"[""lung fibroblast cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0000353|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000453,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000161,,,,,,,BrendaTissueOBO,,BTO:0000161,,,,,,,,,,,,,,,,,,,lung fibroblast cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002309,"[""myoepithelial cell""]",,"Modified smooth muscle cells, contractile in nature, believed to be of ectodermal origin, located around the secretory units of certain glands (salivary, mammary, sweat, and lacrimal glands) between the gland cells and basement membrane, having long dendritic interweaving cytoplasmic processes, and containing myofilaments. It is assumed that contraction of these cells functions to help express secretion from the gland.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000414,,,,,,,,"Modified smooth muscle cells, contractile in nature, believed to be of ectodermal origin, located around the secretory units of certain glands (salivary, mammary, sweat, and lacrimal glands) between the gland cells and basement membrane, having long dendritic interweaving cytoplasmic processes, and containing myofilaments. It is assumed that contraction of these cells functions to help express secretion from the gland.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002309,,,,,,,BrendaTissueOBO,,BTO:0002309,,,,,,,,,,,,,,,,,,,myoepithelial cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100180,"[""Insulin-like growth factor 1 receptor""]",,"An insulin-like growth factor 1 receptor that is encoded in the genome of human. [PRO:JAN, UniProtKB:P08069] |insulin-like growth factor 1 receptor (IGF1R)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300163,,,,,,,,"An insulin-like growth factor 1 receptor that is encoded in the genome of human. [PRO:JAN, UniProtKB:P08069] |insulin-like growth factor 1 receptor (IGF1R)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100180,,,,https://pharos.nih.gov/idg/targets/P08069,,,,,,,,,,,,,IGF1R,,,P08069,,,,,,,,Insulin-like growth factor 1 receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100003,"[""A746-A750del in EGFR(E746-A750del)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100003,,,,,,,,,,,,,,,,,,,,,,,,,,,,A746-A750del in EGFR(E746-A750del),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000842,"[""megagametophyte""]",,The female gametophyte produced by a megaspore.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000495,,,,,,,,The female gametophyte produced by a megaspore.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000842,,,,,,,BrendaTissueOBO,embryo sac|female gametophyte,BTO:0000842,,,,,,,,,,,,,,,,,,,megagametophyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200192,"[""KCNC4 gene""]",,"The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400544,,,,,,,,"The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200192,,,,,,,,,,,,,,,,3749,KCNC4,,,,,,,,,,,KCNC4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100027,"[""Acid-sensing ion channel 3""]",,"An acid-sensing ion channel 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UHC3] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300378,,,,,,,,"An acid-sensing ion channel 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UHC3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100027,,,,https://pharos.nih.gov/idg/targets/Q9UHC3,,,,,,,,,,,,,ASIC3,ACCN3|SLNAC1|TNAC1,,Q9UHC3,,,,,,,,Acid-sensing ion channel 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200332,"[""TRPM8 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400589,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200332,,,,,,,,,,,,,,,,79054,TRPM8,LTRPC6|TRPP8,,,,,,,,,,TRPM8 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400058,"[""Galanin like gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400058,,,,,,,,,,,,,,,,,,,,,,,,,,,,Galanin like gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100139,"[""Receptor tyrosine-protein kinase erbb-2""]",,"A receptor tyrosine-protein kinase erbB-2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P04626] |receptor tyrosine-protein kinase erbb-2 (ERBB2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300152,,,,,,,,"A receptor tyrosine-protein kinase erbB-2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P04626] |receptor tyrosine-protein kinase erbb-2 (ERBB2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100139,,,,https://pharos.nih.gov/idg/targets/P04626,,,,,,,,,,,,,ERBB2,HER2|MLN19|NEU|NGL,,P04626,,,,,,,,Receptor tyrosine-protein kinase erbb-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_7017,"[""lumbosacral lipoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060094,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:7017,,,,NCI:C6500|UMLS_CUI:C1334438,,,disease_ontology,,DOID:7017,,,,,,,,,,,,,,,,,,,lumbosacral lipoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117474,"[""3-ketosteroid receptors""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00102000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117474,,,,,,,,,,,,,,,,,,,,,,,,,,,,3-ketosteroid receptors,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100099,"[""N-formyl peptide receptor 2""]",,"An N-formyl peptide receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25090] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300041,,,,,,,,"An N-formyl peptide receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25090] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100099,,,,https://pharos.nih.gov/idg/targets/P25090,,,,,,,,,,,,,FPR2,FPRH1|FPRL1|LXA4R,,P25090,,,,,,,,N-formyl peptide receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13628,"[""favism""]",,A glucosephosphate dehydrogenase deficiency characterized by a hemolytic reaction to consumption of broad beans.,false,,,http://purl.obolibrary.org/obo/DOID_2862,,,,,,,,A glucosephosphate dehydrogenase deficiency characterized by a hemolytic reaction to consumption of broad beans.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13628,,,,SNOMEDCT_US_2016_03_01:267558001|SNOMEDCT_US_2016_03_01:154801000|UMLS_CUI:C0015702|SNOMEDCT_US_2016_03_01:76500009|MESH:D005236|ICD10CM:D55.0|SNOMEDCT_US_2016_03_01:191172001|NCI:C34607,,,,,DOID:13628,,,,,,,,,,,,,,,,,,,favism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13622,"[""campylobacteriosis""]",,"A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Campylobacter jejuni, which is transmitted_by ingestion of contaminated food or water or transmitted_by contact with infected people or animals. The infection has_symptom diarrhea or has_symptom dysentery, has_symptom abdominal cramps and pain, and has_symptom fever.",false,,,http://purl.obolibrary.org/obo/DOID_0050338,,,,,,,,"A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Campylobacter jejuni, which is transmitted_by ingestion of contaminated food or water or transmitted_by contact with infected people or animals. The infection has_symptom diarrhea or has_symptom dysentery, has_symptom abdominal cramps and pain, and has_symptom fever.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13622,,,DOID:13621,UMLS_CUI:C0006818|MESH:D002169|SNOMEDCT_US_2016_03_01:86500004,(Campylobacter GIT infection (& [diarrhea] or [enteritis]) or (helicobacter gastritis)|Campylobacteriosis (disorder),,disease_ontology,,DOID:13622,http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease,,,,,,,,,,,,,,,,,,campylobacteriosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100244,"[""Potassium voltage-gated channel subfamily V member 2""]",,"A voltage-gated potassium channel KCNV2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8TDN2] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300573,,,,,,,,"A voltage-gated potassium channel KCNV2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8TDN2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100244,,,,https://pharos.nih.gov/idg/targets/Q8TDN2,,,,,,,,,,,,,KCNV2,,,Q8TDN2,,,,,,,,Potassium voltage-gated channel subfamily V member 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117496,"[""Vitamin d3 receptor""]",,"A vitamin D3 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11473] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117466,,,,,,,,"A vitamin D3 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11473] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117496,,,,https://pharos.nih.gov/idg/targets/P11473,,,,,,,,,,,,,VDR,,,P11473,,,,,,,,Vitamin d3 receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100697,"[""Olfactory receptor 8h1""]",,"An olfactory receptor 8H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 8H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100697,,,,https://pharos.nih.gov/idg/targets/Q8NGG4,,,,,,,,,,,,,OR8H1,,,Q8NGG4,,,,,,,,Olfactory receptor 8h1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100550,"[""Tyrosine-protein kinase receptor tyro3""]",,"A tyrosine-protein kinase receptor TYRO3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q06418] |tyrosine-protein kinase receptor tyro3 (TYRO3)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300189,,,,,,,,"A tyrosine-protein kinase receptor TYRO3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q06418] |tyrosine-protein kinase receptor tyro3 (TYRO3)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100550,,,,https://pharos.nih.gov/idg/targets/Q06418,,,,,,,,,,,,,TYRO3,BYK|DTK|RSE|SKY|TIF,,Q06418,,,,,,,,Tyrosine-protein kinase receptor tyro3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400564,"[""Kv7.4/KCNQ4 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400449,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400564,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv7.4/KCNQ4 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300371,"[""Tmem38 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300371,,,,,,,,,,,,,,,,,,,,,,,,,,,,Tmem38 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8955,"[""sideroblastic anemia""]",,An aplastic anemia where the bone marrow produces ringed sideroblasts rather than healthy red blood cells (erythrocytes).,false,,,http://purl.obolibrary.org/obo/DOID_12449,,,,,,,,An aplastic anemia where the bone marrow produces ringed sideroblasts rather than healthy red blood cells (erythrocytes).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8955,,,,ICD10CM:D64.3|SNOMEDCT_US_2016_03_01:41841004|MESH:D000756|ICD9CM:285.0|NCI:C36078|SNOMEDCT_US_2016_03_01:154810008|UMLS_CUI:C0002896|SNOMEDCT_US_2016_03_01:191263002,"ANEMIA SIDEROBLASTIC|Anemia, hypochromic with iron loading",,disease_ontology,,DOID:8955,,,,,,,,,,,,,,,,,,,sideroblastic anemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400457,"[""NR2C/GRIN2C subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400457,,,,,,,,,,,,,,,,,,,,,,,,,,,,NR2C/GRIN2C subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_987,"[""alopecia""]",,A hypotrichosis that is characterized by a loss of hair from the head or body.,false,,,http://purl.obolibrary.org/obo/DOID_4535,,,,,,,,A hypotrichosis that is characterized by a loss of hair from the head or body.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:987,,,,ICD9CM:704.00|SNOMEDCT_US_2016_03_01:201129005|SNOMEDCT_US_2016_03_01:267810004|SNOMEDCT_US_2016_03_01:56317004|SNOMEDCT_US_2016_03_01:278040002|NCI:C50575|OMIM:300042|UMLS_CUI:C0002170|SNOMEDCT_US_2016_03_01:156408004|SNOMEDCT_US_2016_03_01:201130000|SNOMEDCT_US_2016_03_01:270504008|MESH:D000505|OMIM:109200|ICD10CM:L65.9|SNOMEDCT_US_2016_03_01:201157003|ICD9CM:704.0,,,disease_ontology,,DOID:987,,,,,,,,,,,,,,,,,,,alopecia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_980,"[""choroidal sclerosis""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_9799,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:980,,,,ICD9CM:363.4|SNOMEDCT_US_2016_03_01:47638000|ICD9CM:363.40|SNOMEDCT_US_2016_03_01:193464000|ICD10CM:H31.10|SNOMEDCT_US_2016_03_01:267617003|OMIM:215500|ICD10CM:H31.1|UMLS_CUI:C0344297|SNOMEDCT_US_2016_03_01:193461008|SNOMEDCT_US_2016_03_01:406446000|SNOMEDCT_US_2016_03_01:247199007|MESH:C535358,Choroidal degenerations,,disease_ontology,,DOID:980,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,choroidal sclerosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_986,"[""alopecia areata""]",,A hypersensitivity reaction type II disease resulting in the loss of hair on the scalp and elsewhere on the body initially causing bald spots.,false,,,http://purl.obolibrary.org/obo/DOID_417,,,,,,,,A hypersensitivity reaction type II disease resulting in the loss of hair on the scalp and elsewhere on the body initially causing bald spots.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:986,,,,EFO:0004192|SNOMEDCT_US_2016_03_01:201131001|UMLS_CUI:C0002171|MESH:D000506|ICD10CM:L63|ICD10CM:L63.9|SNOMEDCT_US_2016_03_01:238727007|SNOMEDCT_US_2016_03_01:68225006|ICD9CM:704.01|OMIM:610753|OMIM:104000,Circumscribed alopecia,,disease_ontology,,DOID:986,,,,,,,,,,,,,,,,,,,alopecia areata,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100352,"[""Olfactory receptor 14A16""]",,"An olfactory receptor 14A16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHC5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 14A16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHC5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100352,,,,https://pharos.nih.gov/idg/targets/Q8NHC5,,,,,,,,,,,,,OR14A16,OR5AT1,,Q8NHC5,,,,,,,,Olfactory receptor 14A16,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10540,"[""gastric lymphoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_10534,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10540,,,,UMLS_CUI:C0349532|MESH:C535648|NCI:C4636|SNOMEDCT_US_2016_03_01:276811008,Lymphoma of the stomach,,disease_ontology,,DOID:10540,,,,,,,,,,,,,,,,,,,gastric lymphoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10548,"[""cardia cancer""]",,,false,,,http://purl.obolibrary.org/obo/DOID_10534,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10548,,,,SNOMEDCT_US_2016_03_01:187735008|ICD10CM:C16.0|SNOMEDCT_US_2016_03_01:187732006|SNOMEDCT_US_2016_03_01:154447004|UMLS_CUI:C0153417|SNOMEDCT_US_2016_03_01:93738008|ICD9CM:151.0|SNOMEDCT_US_2016_03_01:269526000,Ca cardia - stomach|malignant neoplasm of cardia of stomach,,disease_ontology,,DOID:10548,,,,,,,,,,,,,,,,,,,cardia cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100277,"[""Neuropeptides b/w receptor type 2""]",,"A neuropeptides B/W receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48146] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300068,,,,,,,,"A neuropeptides B/W receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48146] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100277,,,,https://pharos.nih.gov/idg/targets/P48146,,,,,,,,,,,,,NPBWR2,GPR8,,P48146,,,,,,,,Neuropeptides b/w receptor type 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000468,"[""floret""]",,"1. A small or reduced flower, especially one of the grasses and composite plants, such as a daisy. 2. Any of the tight, branched clusters of flower buds that together form a head of cauliflower or broccoli.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000469,,,,,,,,"1. A small or reduced flower, especially one of the grasses and composite plants, such as a daisy. 2. Any of the tight, branched clusters of flower buds that together form a head of cauliflower or broccoli.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000468,,,,,,,BrendaTissueOBO,,BTO:0000468,,,,,,,,,,,,,,,,,,,floret,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001626,"[""laryngeal muscle""]",,"The intrinsic muscles of the larynx are the aryepiglottic(us), arytenoid(eus), cricoarytenoid(eus), cricothyroid(eus), thyroarytenoid(eus), thyroepiglottic(us) and vocal(is).",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The intrinsic muscles of the larynx are the aryepiglottic(us), arytenoid(eus), cricoarytenoid(eus), cricothyroid(eus), thyroarytenoid(eus), thyroepiglottic(us) and vocal(is).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001626,,,,,,,BrendaTissueOBO,,BTO:0001626,,,,,,,,,,,,,,,,,,,laryngeal muscle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117461,"[""Retinoic acid receptors""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00102000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117461,,,,,,,,,,,,,,,,,,,,,,,,,,,,Retinoic acid receptors,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200073,"[""CLCN2 gene""]",,"This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400396,,,,,,,,"This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200073,,,,,,,,,,,,,,,,1181,CLCN2,,,,,,,,,,,CLCN2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100515,"[""Olfactory receptor 2B6""]",,"An olfactory receptor 2B6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58173] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2B6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58173] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100515,,,,https://pharos.nih.gov/idg/targets/P58173,,,,,,,,,,,,,OR2B6,OR2B1|OR2B1P|OR2B5|OR2B6P,,P58173,,,,,,,,Olfactory receptor 2B6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200492,"[""STK32B gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400227,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200492,,,,,,,,,,,,,,,,55351,STK32B,YANK2,,,,,,,,,,STK32B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1827,"[""idiopathic generalized epilepsy""]",,An epilepsy syndrome that is characterised by generalised seizures with no apparent cause which arise from many independent foci (multifocal epilepsies) or from epileptic circuits that involve the whole brain.,false,,,http://purl.obolibrary.org/obo/DOID_1826,,,,,,,,An epilepsy syndrome that is characterised by generalised seizures with no apparent cause which arise from many independent foci (multifocal epilepsies) or from epileptic circuits that involve the whole brain.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1827,,,,OMIM:607628|OMIM:611934|OMIM:606972|OMIM:600669|OMIM:611136|OMIM:604827|OMIM:609750|MESH:D004829|UMLS_CUI:C0014548|SNOMEDCT_US_2016_03_01:192989008|OMIM:614847|NCI:C3021|OMIM:613060|SNOMEDCT_US_2016_03_01:155043003|SNOMEDCT_US_2016_03_01:155038005|OMIM:607682|SNOMEDCT_US_2016_03_01:192994008|OMIM:612899|SNOMEDCT_US_2016_03_01:19598007|OMIM:608762,Generalised epilepsy,,disease_ontology,,DOID:1827,,,,,,,,,,,,,,,,,Xref MGI.,,idiopathic generalized epilepsy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01409932,"[""5-HT3 receptor sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400374,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01409932,,,,,,,,,,,,,,,,,,,,,,,,,,,,5-HT3 receptor sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100475,"[""Serine/threonine-protein kinase sik1""]",,"A serine/threonine-protein kinase SIK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P57059] |serine/threonine-protein kinase sik1 (SIK1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300314,,,,,,,,"A serine/threonine-protein kinase SIK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P57059] |serine/threonine-protein kinase sik1 (SIK1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100475,,,,https://pharos.nih.gov/idg/targets/P57059,,,,,,,,,,,,,SIK1,SIK|SNF1LK,,P57059,,,,,,,,Serine/threonine-protein kinase sik1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100002,"[""5'-AMP-activated protein kinase subunit beta-1""]",,"A 5'-AMP-activated protein kinase subunit beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y478] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300116,,,,,,,,"A 5'-AMP-activated protein kinase subunit beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y478] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100002,,,,https://pharos.nih.gov/idg/targets/Q9Y478,,,,,,,,,,,,,PRKAB1,AMPK,,Q9Y478,,,,,,,,5'-AMP-activated protein kinase subunit beta-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004097,"[""epididymal clear cell""]",,"Cell with empty-appearing cytoplasm; seen normally in the sweat glands, the parathyroid glands, the collecting tubules of the kidneys, and the epididymis; they also appear in some types of cancer.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Cell with empty-appearing cytoplasm; seen normally in the sweat glands, the parathyroid glands, the collecting tubules of the kidneys, and the epididymis; they also appear in some types of cancer.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004097,,,,,,,BrendaTissueOBO,,BTO:0004097,,,,,,,,,,,,,,,,,,,epididymal clear cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100059,"[""Y1047 in PIK3CA(H1047Y)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100059,,,,,,,,,,,,,,,,,,,,,,,,,,,,Y1047 in PIK3CA(H1047Y),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300107,"[""TKL group""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300102,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300107,,,,,,,,,,,,,,,,,,,,,,,,,,,,TKL group,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100169,"[""Serine/threonine-protein kinase greatwall""]",,"A microtubule-associated serine/threonine-protein kinase-like that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96GX5] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300160,,,,,,,,"A microtubule-associated serine/threonine-protein kinase-like that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96GX5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100169,,,,https://pharos.nih.gov/idg/targets/Q96GX5,,,,,,,,,,,,,MASTL,GW|GWL|THC2,,Q96GX5,,,,,,,,Serine/threonine-protein kinase greatwall,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001772,"[""olfactory organ""]",,"The specialized structures subserving the function of the sense of smell, including the olfactory region of the nasal mucosa containing the bipolar cells of origin of the olfactory nerves, together with the olfactory glands.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The specialized structures subserving the function of the sense of smell, including the olfactory region of the nasal mucosa containing the bipolar cells of origin of the olfactory nerves, together with the olfactory glands.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001772,,,,,,,BrendaTissueOBO,organum olfactorium|olfactory neuroepithelium|organ olfactus,BTO:0001772,,,,,,,,,,,,,,,,,,,olfactory organ,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400331,"[""Anion channel-forming bestrophin (bestrophin) family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400331,,,,,,,,,,,,,,,,,,,,,,,,,,,,Anion channel-forming bestrophin (bestrophin) family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200454,"[""OR5AU1 gene""]",,"An olfactory receptor 5AU1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5AU1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200454,,,,,,,,,,,,,,,,390445,OR5AU1,,,,,,,,,,,OR5AU1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200390,"[""PAN3 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400201,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200390,,,,,,,,,,,,,,,,255967,PAN3,,,,,,,,,,,PAN3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000445,"[""TRPM6 kinase domain""]",,"Transient receptor potential cation channel, subfamily M, member 6; ChaK2; HMGX; HOMG; HOMG1; HSH; TRPM6",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Transient receptor potential cation channel, subfamily M, member 6; ChaK2; HMGX; HOMG; HOMG1; HSH; TRPM6",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000445,,,,,,,,,,,,,,,,,,,200446,,,,,,,,,TRPM6 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200758,"[""RGR gene""]",,"An RPE-retinal G protein-coupled receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47804] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"An RPE-retinal G protein-coupled receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47804] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200758,,,,,,,,,,,,,,,,5995,RGR,,,,,,,,,,,RGR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300070,"[""Neuropeptide S receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300070,,,,,,,,,,,,,,,,,,,,,,,,,,,,Neuropeptide S receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400297,"[""YSK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400187,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400297,,,,,,,,,,,,,,,,,,,,,,,,,,,,YSK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000232,"[""LATS1 kinase domain""]",,"LATS, large tumor suppressor, homolog 1 (Drosophila); LATS1; WARTS; wts",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"LATS, large tumor suppressor, homolog 1 (Drosophila); LATS1; WARTS; wts",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000232,,,,,,,,,,,,,,,,,,,200222,,,,,,,,,LATS1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9155,"[""mucocutaneous leishmaniasis""]",,"A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus Leishmania. The infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa.",false,,,http://purl.obolibrary.org/obo/DOID_9065,,,,,,,,"A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus Leishmania. The infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9155,,,,UMLS_CUI:C1328252|ICD9CM:085.5|MESH:D007897|SNOMEDCT_US_2016_03_01:39625001|SNOMEDCT_US_2016_03_01:403135004|ICD10CM:B55.2|SNOMEDCT_US_2016_03_01:186810001,"New World cutaneous leishmaniasis|American mucocutaneous leishmaniasis (disorder)|American cutaneous leishmaniasis|American Cutaneous Leishmaniasis|Mucocutaneous leishmaniasis, (American)|Cutaneous leishmaniasis, American|American mucocutaneous leishmaniasis|Mucocutaneous leishmaniasis, American",,disease_ontology,,DOID:9155,http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,mucocutaneous leishmaniasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000326,"[""THR315 in ABL1(E255K)-phosphorylated""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000326,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR315 in ABL1(E255K)-phosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100525,"[""Tyrosine-protein kinase receptor tie-1""]",,"tyrosine-protein kinase receptor tie-1 (TIE1)  with  no mutation  in a nonphosphorylated state|A tyrosine-protein kinase receptor Tie-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35590] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300234,,,,,,,,"tyrosine-protein kinase receptor tie-1 (TIE1)  with  no mutation  in a nonphosphorylated state|A tyrosine-protein kinase receptor Tie-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35590] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100525,,,,https://pharos.nih.gov/idg/targets/P35590,,,,,,,,,,,,,TIE1,TIE,,P35590,,,,,,,,Tyrosine-protein kinase receptor tie-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200752,"[""GPR65 gene""]",,"A psychosine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8IYL9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A psychosine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8IYL9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200752,,,,,,,,,,,,,,,,8477,GPR65,TDAG8,,,,,,,,,,GPR65 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000476,"[""foot""]",,1: The terminal part of the vertebrate leg upon which an individual stands. 2: An invertebrate organ of locomotion or attachment; especially: a ventral muscular surface or process of a mollusk.,false,,,http://purl.obolibrary.org/obo/BTO_0001492|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,1: The terminal part of the vertebrate leg upon which an individual stands. 2: An invertebrate organ of locomotion or attachment; especially: a ventral muscular surface or process of a mollusk.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000476,,,,,,,BrendaTissueOBO,,BTO:0000476,,,,,,,,,,,,,,,,,,,foot,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000221,"[""KIT(V559D,V654A) kinase domain""]",,V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; C-Kit; KIT; PBT; SCFR,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; C-Kit; KIT; PBT; SCFR,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000221,,,,,,,,,,,,,,,,,,,200221,,,,,,,,,"KIT(V559D,V654A) kinase domain",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000442,"[""TRKA kinase domain""]",,"Neurotrophic tyrosine kinase, receptor, type 1; DKFZp781I14186; MTC; NTRK1; p140-TrkA; TRK; TRK1; TRKA; Trk-A",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Neurotrophic tyrosine kinase, receptor, type 1; DKFZp781I14186; MTC; NTRK1; p140-TrkA; TRK; TRK1; TRKA; Trk-A",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000442,,,,,,,,,,,,,,,,,,,200443,,,,,,,,,TRKA kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200313,"[""TMC5 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400372,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200313,,,,,,,,,,,,,,,,79838,TMC5,,,,,,,,,,,TMC5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200248,"[""PSKH1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400177,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200248,,,,,,,,,,,,,,,,5681,PSKH1,,,,,,,,,,,PSKH1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000376,"[""THR670 in KIT-autoinhibited""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000376,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR670 in KIT-autoinhibited,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8584,"[""Burkitt lymphoma""]",,A mature B-cell neoplasm of B-cells found in the germinal center.,false,,,http://purl.obolibrary.org/obo/DOID_706,,,,,,,,A mature B-cell neoplasm of B-cells found in the germinal center.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8584,,,,SNOMEDCT_US_2016_03_01:190022008|SNOMEDCT_US_2016_03_01:188509006|OMIM:113970|SNOMEDCT_US_2016_03_01:397400006|MESH:D002051|SNOMEDCT_US_2016_03_01:277571004|SNOMEDCT_US_2016_03_01:77381001|SNOMEDCT_US_2016_03_01:190023003|ICD10CM:C83.70|NCI:C2912|SNOMEDCT_US_2016_03_01:154581008|SNOMEDCT_US_2016_03_01:188518008|UMLS_CUI:C0006413|SNOMEDCT_US_2016_03_01:22197008|ICD9CM:200.2|NCI:C7400|ICD10CM:C83.7|SNOMEDCT_US_2016_03_01:118617000,"malignant lymphoma, Burkitt's type|Burkitt's tumor or lymphoma|small Non-Cleaved cell Lymphoma, Burkitt's type|Burkitt's Lymphoma|Burkitt lymphoma/leukaemia|Burkitt's tumor",,disease_ontology,,DOID:8584,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Burkitt lymphoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1279,"[""ocular motility disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5656,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1279,,,,ICD9CM:378.9|MESH:D015835|SNOMEDCT_US_2016_03_01:45030009|UMLS_CUI:C0028850,eye movement disorder|disorder of eye movements,,disease_ontology,,DOID:1279,,,,,,,,,,,,,,,,,,,ocular motility disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12798,"[""mucopolysaccharidosis""]",,A lysosomal storage disease that involves the accumulation of glycosaminoglycans in the tissues and their excretion in the urine.,false,,,http://purl.obolibrary.org/obo/DOID_3211,,,,,,,,A lysosomal storage disease that involves the accumulation of glycosaminoglycans in the tissues and their excretion in the urine.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12798,,,DOID:14716,SNOMEDCT_US_2016_03_01:267452003|OMIM:607014|ICD10CM:E76.3|OMIM:252700|SNOMEDCT_US_2016_03_01:11380006|ORDO:79213|SNOMEDCT_US_2016_03_01:190942001|SNOMEDCT_US_2016_03_01:190936000|UMLS_CUI:C0026703|ICD9CM:277.5|MESH:D009083|NCI:C61259,,,disease_ontology,,DOID:12798,,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping submitted by NeuroDevNet. [LS].",,mucopolysaccharidosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12799,"[""mucopolysaccharidosis II""]",,A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme iduronate sulfatase.,false,,,http://purl.obolibrary.org/obo/DOID_12798,,,,,,,,A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme iduronate sulfatase.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12799,,,,OMIM:309900|NCI:C61260|ICD10CM:E76.1|UMLS_CUI:C0026705|MESH:D016532|SNOMEDCT_US_2016_03_01:190936000|SNOMEDCT_US_2016_03_01:61413000|SNOMEDCT_US_2016_03_01:70737009,"Hunter syndrome|deficiency of iduronate-2-sulphatase|Hunter's syndrome|MPS II - Hunter syndrome|Mucopolysaccharidosis, MPS-II (disorder)",,disease_ontology,,DOID:12799,,,,,,,,,,,,,,,,,OMIM mapping submitted by NeuroDevNet. [LS].,,mucopolysaccharidosis II,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200486,"[""OR1E3 gene""]",,"An olfactory receptor 1E3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZA6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1E3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZA6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200486,,,,,,,,,,,,,,,,8389,OR1E3,OR1E3P,,,,,,,,,,OR1E3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000186,"[""CXCL5""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000186,,,,,,,,,,,,,,,,,,,,,,,,,,,,CXCL5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000735,"[""sporophyte""]",,The individual or generation of a plant exhibiting alternation of generations that bears asexual spores.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000720,,,,,,,,The individual or generation of a plant exhibiting alternation of generations that bears asexual spores.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000735,,,,,,,BrendaTissueOBO,,BTO:0000735,,,,,,,,,,,,,,,,,,,sporophyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200487,"[""SRPK2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400226,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200487,,,,,,,,,,,,,,,,6733,SRPK2,,,,,,,,,,,SRPK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000459,"[""WEE2 kinase domain""]",,Wee1-like protein kinase 2; FLJ16107; WEE1B; WEE2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Wee1-like protein kinase 2; FLJ16107; WEE1B; WEE2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000459,,,,,,,,,,,,,,,,,,,200461,,,,,,,,,WEE2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100306,"[""Amiloride-sensitive sodium channel subunit gamma""]",,"An amiloride-sensitive sodium channel subunit gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51170] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300480,,,,,,,,"An amiloride-sensitive sodium channel subunit gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51170] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100306,,,,https://pharos.nih.gov/idg/targets/P51170,,,,,,,,,,,,,SCNN1G,,,P51170,,,,,,,,Amiloride-sensitive sodium channel subunit gamma,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_0349989,"[""Eukaryotic two domain clade \\\""E\\\"" sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_0349989,,,,,,,,,,,,,,,,,,,,,,,,,,,,"Eukaryotic two domain clade ""E"" sub-subfamily gene",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4451,"[""renal carcinoma""]",,A kidney cancer that derives_from the lining of the proximal convoluted tubule (the very small tubes in the kidney that filter the blood and remove waste products).,false,,,http://purl.obolibrary.org/obo/DOID_263|http://purl.obolibrary.org/obo/DOID_305,,,,,,,,A kidney cancer that derives_from the lining of the proximal convoluted tubule (the very small tubes in the kidney that filter the blood and remove waste products).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4451,,,,SNOMEDCT_US_2016_03_01:254915003|UMLS_CUI:C1378703|NCI:C9384,carcinoma of kidney|kidney carcinoma,,disease_ontology,,DOID:4451,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,renal carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200477,"[""OR1A1 gene""]",,"An olfactory receptor 1A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P1Q5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P1Q5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200477,,,,,,,,,,,,,,,,8383,OR1A1,,,,,,,,,,,OR1A1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100132,"[""Golgi ph regulator b""]",,"A Golgi pH regulator B that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0CG08] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300350,,,,,,,,"A Golgi pH regulator B that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0CG08] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100132,,,,https://pharos.nih.gov/idg/targets/P0CG08,,,,,,,,,,,,,GPR89B,GPHRB,,P0CG08,,,,,,,,Golgi ph regulator b,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200326,"[""TRPM1 gene""]",,"This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400583,,,,,,,,"This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200326,,,,,,,,,,,,,,,,4308,TRPM1,LTRPC1|MLSN|MLSN1,,,,,,,,,,TRPM1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200380,"[""PIK3C2G gene""]",,"The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03491009,,,,,,,,"The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200380,,,,,,,,,,,,,,,,5288,PIK3C2G,,,,,,,,,,,PIK3C2G gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000452,"[""ULK1 kinase domain""]",,Serine/threonine-protein kinase ULK1; Unc-51-like kinase 1 (C. elegans); ATG1; FLJ38455; FLJ46475; ULK1; UNC51; Unc51.1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase ULK1; Unc-51-like kinase 1 (C. elegans); ATG1; FLJ38455; FLJ46475; ULK1; UNC51; Unc51.1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000452,,,,,,,,,,,,,,,,,,,200455,,,,,,,,,ULK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100242,"[""Protein kinase c epsilon type""]",,"protein kinase c epsilon type (KPCE)  with  no mutation  in a nonphosphorylated state|A protein kinase C epsilon that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q02156] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300278,,,,,,,,"protein kinase c epsilon type (KPCE)  with  no mutation  in a nonphosphorylated state|A protein kinase C epsilon that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q02156] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100242,,,,https://pharos.nih.gov/idg/targets/Q02156,,,,,,,,,,,,,PRKCE,PKCE,,Q02156,,,,,,,,Protein kinase c epsilon type,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400210,"[""PKN family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400210,,,,,,,,,,,,,,,,,,,,,,,,,,,,PKN family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400470,"[""SCN4B family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400370,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400470,,,,,,,,,,,,,,,,,,,,,,,,,,,,SCN4B family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000077,"[""posterior midgut""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000077,,,,,,,BrendaTissueOBO,,BTO:0000077,,,,,,,,,,,,,,,,,,,posterior midgut,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4929,"[""tubular adenocarcinoma""]",,An adenocarcinoma that derives_from epithelial cells originating in glandular tissue. The tumor has branched angular tubules embedded in a loose fibrous stroma.,false,,,http://purl.obolibrary.org/obo/DOID_299,,,,,,,,An adenocarcinoma that derives_from epithelial cells originating in glandular tissue. The tumor has branched angular tubules embedded in a loose fibrous stroma.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4929,,,,MESH:D000230|UMLS_CUI:C0205645|SNOMEDCT_US_2016_03_01:4631006|NCI:C65192,tubular carcinoma|tubular adenocarcinoma (morphologic abnormality),,disease_ontology,,DOID:4929,,,,,,,,,,,,,,,,,,,tubular adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000053,"[""Large neuromedin N""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000053,,,,,,,,,,,,,,,,,,,,,,,,,,,,Large neuromedin N,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005068,"[""SK-CO15 cell""]",,Human intestinal epithelial cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000003,,,,,,,,Human intestinal epithelial cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005068,XPMUser,2011-03-07T02:56:04Z,,,,,BrendaTissueOBO,,BTO:0005068,,,,,,,,,,,,,,,,,,,SK-CO15 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200260,"[""MRGPRG gene""]",,"A mas-related G-protein coupled receptor G that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86SM5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400063,,,,,,,,"A mas-related G-protein coupled receptor G that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86SM5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200260,,,,,,,,,,,,,,,,386746,MRGPRG,GPR169|MRGG,,,,,,,,,,MRGPRG gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300414,"[""GRID1 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300414,,,,,,,,,,,,,,,,,,,,,,,,,,,,GRID1 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002383,"[""MKN-74 cell""]",,Well differentiated human gastric adenocarcinoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002380,,,,,,,,Well differentiated human gastric adenocarcinoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002383,,,,,,,BrendaTissueOBO,MKN74 cell,BTO:0002383,,,,,,,,,,,,,,,,,,,MKN-74 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000047,"[""adrenal gland""]",,"Either of a pair of complex endocrine organs near the anterior medial border of the kidney consisting of a mesodermal cortex that produces glucocorticoid, mineralocorticoid, and androgenic hormones and an ectodermal medulla that produces epinephrine and norepinephrine.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001491|http://purl.obolibrary.org/obo/UBERON_0001062|http://purl.obolibrary.org/obo/BTO_0001488,,,,,,,,"Either of a pair of complex endocrine organs near the anterior medial border of the kidney consisting of a mesodermal cortex that produces glucocorticoid, mineralocorticoid, and androgenic hormones and an ectodermal medulla that produces epinephrine and norepinephrine.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000047,,,,,,,BrendaTissueOBO,glandula suprarenalis|adrenal|suprarenal capsule|epinephros|adrenal capsule|atrabiliary capsule|suprarenal gland,BTO:0000047,,,,,,,,,,,,,,,,,,,adrenal gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10933,"[""obsessive-compulsive disorder""]",,"An anxiety disorder that involves unwanted and repeated thoughts, feelings, ideas, sensations (obsessions), or behaviors that make them feel driven to do something (compulsions).",false,,,http://purl.obolibrary.org/obo/DOID_2030,,,,,,,,"An anxiety disorder that involves unwanted and repeated thoughts, feelings, ideas, sensations (obsessions), or behaviors that make them feel driven to do something (compulsions).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10933,,,,SNOMEDCT_US_2016_03_01:192406007|SNOMEDCT_US_2016_03_01:71478004|NCI:C88411|SNOMEDCT_US_2016_03_01:191736004|MESH:D009771|ICD10CM:F42|ICD9CM:300.3|SNOMEDCT_US_2016_03_01:192411009|SNOMEDCT_US_2016_03_01:191739006|UMLS_CUI:C0028768,obsessive compulsive disorder|Anancastic neurosis,,disease_ontology,,DOID:10933,,,,,,,,,,,,,,,,,,,obsessive-compulsive disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10939,"[""antisocial personality disorder""]",,"A personality disorder that involves a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood.",false,,,http://purl.obolibrary.org/obo/DOID_1510,,,,,,,,"A personality disorder that involves a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10939,,,,ICD10CM:F60.2|SNOMEDCT_US_2016_03_01:192487000|SNOMEDCT_US_2016_03_01:191769004|MESH:D000987|SNOMEDCT_US_2016_03_01:268759009|ICD9CM:301.7|NCI:C88413|UMLS_CUI:C0003431|SNOMEDCT_US_2016_03_01:26665006|SNOMEDCT_US_2016_03_01:191777000,Asocial personality|sociopathic personality|Psychopathic personality|Dissocial personality disorder|Psychopath.personality|Psychopathic personality disorder,,disease_ontology,,DOID:10939,,,,,,,,,,,,,,,,,,,antisocial personality disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10937,"[""impulse control disorder""]",,A disease of mental health that involves a failure to resist an impulsive act or behaviour that may be harmful to self or others.,false,,,http://purl.obolibrary.org/obo/DOID_150,,,,,,,,A disease of mental health that involves a failure to resist an impulsive act or behaviour that may be harmful to self or others.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10937,,,,ICD10CM:F63.9|NCI:C34723|ICD9CM:312.30|MESH:D007174|SNOMEDCT_US_2016_03_01:192098008|SNOMEDCT_US_2016_03_01:66347000|SNOMEDCT_US_2016_03_01:192095006|UMLS_CUI:C0021122,,,disease_ontology,,DOID:10937,,,,,,,,,,,,,,,,,,,impulse control disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000332,"[""PFCDPK1(P.falciparum) kinase domain""]",,Calcium-dependent protein kinase 1; CDPK1; CPK; PFB0815w; PFCDPK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Calcium-dependent protein kinase 1; CDPK1; CPK; PFB0815w; PFCDPK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000332,,,,,,,,,,,,,,,,,,,200315,,,,,,,,,PFCDPK1(P.falciparum) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200014,"[""ADORA2A gene""]",,"An adenosine receptor A2a that is encoded in the genome of human. [PRO:WCB, UniProtKB:P29274] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400018,,,,,,,,"An adenosine receptor A2a that is encoded in the genome of human. [PRO:WCB, UniProtKB:P29274] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200014,,,,,,,,,,,,,,,,135,ADORA2A,ADORA2,,,,,,,,,,ADORA2A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400438,"[""KCNMB/KCNMB1 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400358,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400438,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNMB/KCNMB1 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000258,"[""PHE268 in HIPK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000258,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE268 in HIPK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400367,"[""Polycystin cation channel (pcc) family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400367,,,,,,,,,,,,,,,,,,,,,,,,,,,,Polycystin cation channel (pcc) family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100083,"[""Serine/threonine-protein kinase chk2""]",,"A serine/threonine-protein kinase Chk2 that is encoded in the genome of human. [OMA:HUMAN19404, PRO:DNx] |serine/threonine-protein kinase chk2 (CHK2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300139,,,,,,,,"A serine/threonine-protein kinase Chk2 that is encoded in the genome of human. [OMA:HUMAN19404, PRO:DNx] |serine/threonine-protein kinase chk2 (CHK2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100083,,,,https://pharos.nih.gov/idg/targets/O96017,,,,,,,,,,,,,CHEK2,CDS1|CHK2|RAD53,,O96017,,,,,,,,Serine/threonine-protein kinase chk2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000214,"[""KIT kinase domain""]",,V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; C-Kit; KIT; PBT; SCFR,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; C-Kit; KIT; PBT; SCFR,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000214,,,,,,,,,,,,,,,,,,,200214,,,,,,,,,KIT kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200432,"[""PLK3 gene""]",,"Cytokine-inducible kinase is a putative serine/threonine kinase.  CNK contains both a catalytic domain and a putative regulatory domain.  It may play a role in regulation of cell cycle progression and tumorigenesis. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400211,,,,,,,,"Cytokine-inducible kinase is a putative serine/threonine kinase.  CNK contains both a catalytic domain and a putative regulatory domain.  It may play a role in regulation of cell cycle progression and tumorigenesis. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200432,,,,,,,,,,,,,,,,1263,PLK3,CNK|FNK|PRK,,,,,,,,,,PLK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000421,"[""connective tissue""]",,"The tissue which binds together and is the support of the various structures of the body. It is made up of fibroblasts, fibroglia, collagen fibrils, and elastic fibrils. It is derived from the mesoderm and in a broad sense includes the collagenous, elastic, mucous, reticular, osseous, and cartilaginous tissue. Some also include the blood in this group of tissues. Connective tissue is classified according to concentration of fibers as loose (areolar) and dense, the latter having more abundant fibers than the former.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The tissue which binds together and is the support of the various structures of the body. It is made up of fibroblasts, fibroglia, collagen fibrils, and elastic fibrils. It is derived from the mesoderm and in a broad sense includes the collagenous, elastic, mucous, reticular, osseous, and cartilaginous tissue. Some also include the blood in this group of tissues. Connective tissue is classified according to concentration of fibers as loose (areolar) and dense, the latter having more abundant fibers than the former.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000421,,,,,,,BrendaTissueOBO,Bindegewebe,BTO:0000421,,,,,,,,,,,,,,,,,,,connective tissue,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_50347,"[""L-asparagine residue""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_33700,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:50347,,,CHEBI:29956|CHEBI:40859,PDBeChem:ASN_LL|RESID:AA0003,L-asparagine residue,,chebi_ontology,Asn|C4H6N2O2|L-asparagine|ASPARAGINE|114.043|N|L-asparaginyl|-Asn-|Asp(NH2)|0|114.10272,CHEBI:50347,http://purl.obolibrary.org/obo/chebi#3_STAR,,,,,,,,,,,,,,,,,,L-asparagine residue,,,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200367,"[""NRBP2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400198,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200367,,,,,,,,,,,,,,,,340371,NRBP2,,,,,,,,,,,NRBP2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100531,"[""Olfactory receptor 2J2""]",,"An olfactory receptor 2J2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76002] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2J2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76002] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100531,,,,https://pharos.nih.gov/idg/targets/O76002,,,,,,,,,,,,,OR2J2,,,O76002,,,,,,,,Olfactory receptor 2J2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000082,"[""LEU86 in MELK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000082,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU86 in MELK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200769,"[""SMO gene""]",,"A smoothened that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99835] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400005,,,,,,,,"A smoothened that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99835] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200769,,,,,,,,,,,,,,,,6608,SMO,SMOH,,,,,,,,,,SMO gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300543,"[""Kv3.3/KCNC3 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300443,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300543,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv3.3/KCNC3 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3213,"[""demyelinating disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1289,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3213,,,,NCI:C34527|UMLS_CUI:C0011303|MESH:D003711,demyelinating disorder,,disease_ontology,,DOID:3213,,,,,,,,,,,,,,,,,,,demyelinating disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100057,"[""C-C chemokine receptor type 5""]",,"A C-C chemokine receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51681] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300095,,,,,,,,"A C-C chemokine receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51681] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100057,,,,https://pharos.nih.gov/idg/targets/P51681,,,,,,,,,,,,,CCR5,CMKBR5,,P51681,,,,,,,,C-C chemokine receptor type 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000096,"[""urinary bladder cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000096,,,,,,,BrendaTissueOBO,,BTO:0000096,,,,,,,,,,,,,,,,,,,urinary bladder cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200306,"[""OR10G9 gene""]",,"An olfactory receptor 10G9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10G9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200306,,,,,,,,,,,,,,,,219870,OR10G9,OR10G10P,,,,,,,,,,OR10G9 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100288,"[""Olfactory receptor 10a2""]",,"An olfactory receptor 10A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H208] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H208] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100288,,,,https://pharos.nih.gov/idg/targets/Q9H208,,,,,,,,,,,,,OR10A2,OR10A2P,,Q9H208,,,,,,,,Olfactory receptor 10a2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100481,"[""Olfactory receptor 1D2""]",,"An olfactory receptor 1D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P34982] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P34982] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100481,,,,https://pharos.nih.gov/idg/targets/P34982,,,,,,,,,,,,,OR1D2,OLFR1,,P34982,,,,,,,,Olfactory receptor 1D2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200579,"[""CMPK2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200579,,,,,,,,,,,,,,,,,,,,,,,,,,,,CMPK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100034,"[""Beta-2 adrenergic receptor""]",,"A beta-2 adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P07550] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300094,,,,,,,,"A beta-2 adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P07550] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100034,,,,https://pharos.nih.gov/idg/targets/P07550,,,,,,,,,,,,,ADRB2,ADRB2R|B2AR,,P07550,,,,,,,,Beta-2 adrenergic receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100511,"[""Tyrosine-protein kinase styk1""]",,"A tyrosine-protein kinase STYK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6J9G0] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300230,,,,,,,,"A tyrosine-protein kinase STYK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6J9G0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100511,,,,https://pharos.nih.gov/idg/targets/Q6J9G0,,,,,,,,,,,,,STYK1,NOK,,Q6J9G0,,,,,,,,Tyrosine-protein kinase styk1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400205,"[""PHK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400205,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100546,"[""Olfactory receptor 2T2""]",,"An olfactory receptor 2T2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF00] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2T2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF00] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100546,,,,https://pharos.nih.gov/idg/targets/Q6IF00,,,,,,,,,,,,,OR2T2,OR2T2P,,Q6IF00,,,,,,,,Olfactory receptor 2T2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2226,"[""myeloproliferative neoplasm""]",,"A myeloid neoplasm that is characterized by a group of slow growing blood cancers in which large numbers of abnormal red blood cells, white blood cells, or platelets grow and spread in the bone marrow and the peripheral blood.",false,,,http://purl.obolibrary.org/obo/DOID_0070004,,,,,,,,"A myeloid neoplasm that is characterized by a group of slow growing blood cancers in which large numbers of abnormal red blood cells, white blood cells, or platelets grow and spread in the bone marrow and the peripheral blood.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2226,,,DOID:6002,SNOMEDCT_US_2016_03_01:20921005|UMLS_CUI:C1292778|SNOMEDCT_US_2016_03_01:115248004|ICD10CM:D47.1|NCI:C4345|SNOMEDCT_US_2016_03_01:128842008|SNOMEDCT_US_2016_03_01:109993000,"chronic myeloproliferative disease|CMPD, U|CMPD",,disease_ontology,,DOID:2226,,,,,,,,,,,,,,,,,,,myeloproliferative neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200396,"[""OR51G1 gene""]",,"An olfactory receptor 51G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 51G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200396,,,,,,,,,,,,,,,,79324,OR51G1,OR51G3P,,,,,,,,,,OR51G1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62300000,"[""gatekeeper residue""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_33700,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62300000,,,,,,,,,,,,,,,,,,,,,,,,,,,,gatekeeper residue,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217552,"[""RXRB gene""]",,"This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_00217468,,,,,,,,"This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217552,,,,,,,,,,,,,,,,6257,RXRB,NR2B2,,,,,,,,,,RXRB gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5041,"[""esophageal cancer""]",,A gastrointestinal system cancer that is located_in the esophagus.,false,,,http://purl.obolibrary.org/obo/DOID_3119|http://purl.obolibrary.org/obo/DOID_6050,,,,,,,,A gastrointestinal system cancer that is located_in the esophagus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5041,,,DOID:1104|DOID:10448|DOID:10291|DOID:10292|DOID:1102,OMIM:133239|SNOMEDCT_US_2016_03_01:187725002|SNOMEDCT_US_2016_03_01:126817006|SNOMEDCT_US_2016_03_01:154443000|ICD10CM:C15.5|NCI:C3534|SNOMEDCT_US_2016_03_01:93877002|UMLS_CUI:C0153416|NCI:C3533|ICD9CM:150.8|SNOMEDCT_US_2016_03_01:93656003|NCI:C3535|UMLS_CUI:C0153415|ICD9CM:150.2|SNOMEDCT_US_2016_03_01:187727005|UMLS_CUI:C0153413|SNOMEDCT_US_2016_03_01:93895004|SNOMEDCT_US_2016_03_01:269523008|ICD9CM:150.4|NCI:C3028|ICD10CM:C15.4|ICD9CM:150.5|ICD9CM:150.3|SNOMEDCT_US_2016_03_01:269524002|UMLS_CUI:C0014859|SNOMEDCT_US_2016_03_01:94119000|UMLS_CUI:C0153414|MESH:D004938|SNOMEDCT_US_2016_03_01:187726001|ICD10CM:C15.3|NCI:C4764|SNOMEDCT_US_2016_03_01:187724003|SNOMEDCT_US_2016_03_01:154444006|UMLS_CUI:C0496775|SNOMEDCT_US_2016_03_01:187729008,malignant neoplasm of upper third esophagus|malignant neoplasm of middle third of oesophagus|malignant tumor of abdominal esophagus|malignant tumor of the middle Third of the esophagus|malignant neoplasm of proximal third of esophagus|malignant neoplasm of distal third of esophagus|esophagus cancer|Ca middle third oesophagus|malignant neoplasm of lower third of oesophagus|malignant tumor of Proximal Third of esophagus|malignant tumor of Distal Third of esophagus|Ca lower third oesophagus,,disease_ontology,,DOID:5041,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,esophageal cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300511,"[""GABRA6 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300511,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRA6 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000068,"[""CDC2L1 kinase domain""]",,Cyclin-dependent kinase 11B; CDC2L1; CDC2L2; CDK11; CDK11B; CDK11-p110; CDK11-p46; CDK11-p58; CLK-1; FLJ59152; p58; p58CDC2L1; p58CLK-1; PITSLRE; PK58,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Cyclin-dependent kinase 11B; CDC2L1; CDC2L2; CDK11; CDK11B; CDK11-p110; CDK11-p46; CDK11-p58; CLK-1; FLJ59152; p58; p58CDC2L1; p58CLK-1; PITSLRE; PK58,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000068,,,,,,,,,,,,,,,,,,,200071,,,,,,,,,CDC2L1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004050,"[""BEL-7402 cell""]",,Human liver cancer cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0000578|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human liver cancer cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004050,,,,,,,BrendaTissueOBO,BEL7402 cell,BTO:0004050,,,,,,,,,,,,,,,,,,,BEL-7402 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400364,"[""Atp-gated p2x receptor cation channel (p2x receptor) family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400364,,,,,,,,,,,,,,,,,,,,,,,,,,,,Atp-gated p2x receptor cation channel (p2x receptor) family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000056,"[""BRSK1 kinase domain""]",,BR serine/threonine kinase 1; BRSK1; FLJ43009; KIAA1811,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,BR serine/threonine kinase 1; BRSK1; FLJ43009; KIAA1811,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000056,,,,,,,,,,,,,,,,,,,200057,,,,,,,,,BRSK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200317,"[""OR10K1 gene""]",,"An olfactory receptor 10K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200317,,,,,,,,,,,,,,,,391109,OR10K1,,,,,,,,,,,OR10K1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1380,"[""endometrial cancer""]",,A uterine cancer that is located_in tissues lining the uterus.,false,,,http://purl.obolibrary.org/obo/DOID_363,,,,,,,,A uterine cancer that is located_in tissues lining the uterus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1380,,,DOID:5654,OMIM:608089|UMLS_CUI:C0014170|ICD10CM:C54.1|SNOMEDCT_US_2016_03_01:123844007|UMLS_CUI:C0007103|EFO:0004230|KEGG:05213|NCI:C27815|MESH:D016889|NCI:C3012,malignant neoplasm of endometrium|endometrial Ca|primary malignant neoplasm of endometrium|malignant endometrial neoplasm|neoplasm of endometrium (disorder)|endometrial neoplasm|tumor of Endometrium,,disease_ontology,,DOID:1380,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,endometrial cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13809,"[""familial combined hyperlipidemia""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_1168,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13809,,,,OMIM:144250|SNOMEDCT_US_2016_03_01:299465007|UMLS_CUI:C0020474|SNOMEDCT_US_2016_03_01:238040008|MESH:D006950|SNOMEDCT_US_2016_03_01:154742006|SNOMEDCT_US_2016_03_01:190780005|SNOMEDCT_US_2016_03_01:48190005|ICD10CM:E78.4,mixed hyperlipidaemia|type IIb hyperlipoproteinemia|hyperbetalipoproteinemia with prebetalipoproteinemia|familial combined hyperlipidemia (disorder) [Ambiguous]|familial combined hyperlipidemia (disorder)|mixed hyperlipidemia|mixed hyperlipidemia (disorder)|familial multiple lipoprotein-type hyperlipidemia (disorder),,disease_ontology,,DOID:13809,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,familial combined hyperlipidemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200181,"[""CHUK gene""]",,"This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400164,,,,,,,,"This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200181,,,,,,,,,,,,,,,,1147,CHUK,IKKA|TCF16,,,,,,,,,,CHUK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001959,"[""PEER cell""]",,"Human T cell leukemia; established from the peripheral blood of a 4-year-old girl with T cell acute lymphoblastic leukemia (T-ALL) in second relapse in 1977; cell lines BE-13 (DSM ACC 396) and PEER show identical DNA fingerprints and hence share common origin, presumably due to cross-ontamination; however, their diploid and tetraploid karyotypes indicative of earlier and later passage numbers, respectively, suggest that BE-13 is derived from PEER, rather than vice-versa.",false,,,http://purl.obolibrary.org/obo/BTO_0002504|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002144,,,,,,,,"Human T cell leukemia; established from the peripheral blood of a 4-year-old girl with T cell acute lymphoblastic leukemia (T-ALL) in second relapse in 1977; cell lines BE-13 (DSM ACC 396) and PEER show identical DNA fingerprints and hence share common origin, presumably due to cross-ontamination; however, their diploid and tetraploid karyotypes indicative of earlier and later passage numbers, respectively, suggest that BE-13 is derived from PEER, rather than vice-versa.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001959,,,,,,,BrendaTissueOBO,,BTO:0001959,,,,,,,,,,,,,,,,,,,PEER cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117510,"[""Nuclear receptor subfamily 2 group f member 6""]",,"A nuclear receptor subfamily 2 group F member 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10588] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117471,,,,,,,,"A nuclear receptor subfamily 2 group F member 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10588] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117510,,,,https://pharos.nih.gov/idg/targets/P10588,,,,,,,,,,,,,NR2F6,ERBAL2,,P10588,,,,,,,,Nuclear receptor subfamily 2 group f member 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000308,"[""THR187 in PKMYT1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000308,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR187 in PKMYT1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000092,"[""MET104 in AMPK-alpha1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000092,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET104 in AMPK-alpha1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80139,"[""Neuromedin B""]",NMB,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C15865,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,NMB,,,CHEBI:80139,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80139,,,,,Neuromedin B,,CHEBI:80139,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1227,"[""neutropenia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_12987,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1227,,,,MESH:D009503|SNOMEDCT_US_2016_03_01:191336001|SNOMEDCT_US_2016_03_01:142928004|SNOMEDCT_US_2016_03_01:72885007|ICD10CM:D70.9|ICD10CM:D70|SNOMEDCT_US_2016_03_01:303011007|ICD9CM:288.0|UMLS_CUI:C0027947|ICD9CM:288.00,,,disease_ontology,,DOID:1227,,,,,,,,,,,,,,,,,,,neutropenia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12270,"[""coloboma""]",,"An eye disease characterized by missing pieces of tissue in structures that form the eye, such as the iris, retina, choroid or optic disc.",false,,,http://purl.obolibrary.org/obo/DOID_5614,,,,,,,,"An eye disease characterized by missing pieces of tissue in structures that form the eye, such as the iris, retina, choroid or optic disc.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12270,,,,ICD10CM:Q13.0|SNOMEDCT_US_2016_03_01:93390002|SNOMEDCT_US_2016_03_01:92828000|ORDO:98945|MESH:D003103|OMIM:120300|OMIM:120200|OMIM:216820|ORDO:194|NCI:C98877|UMLS_CUI:C0009363,coloboma of eye|coloboma of macula|congenital ocular coloboma,,disease_ontology,,DOID:12270,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,coloboma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003422,"[""AF5 cell""]",,Immortalized mesencephalic-derived AF5 cell line. The characterized AF5 rat neural-derived cell line displays GABAergic properties during culture in vitro.,false,,,http://purl.obolibrary.org/obo/BTO_0000947|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Immortalized mesencephalic-derived AF5 cell line. The characterized AF5 rat neural-derived cell line displays GABAergic properties during culture in vitro.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003422,,,,,,,BrendaTissueOBO,,BTO:0003422,,,,,,,,,,,,,,,,,,,AF5 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000197,"[""IRAK3 kinase domain""]",,Interleukin-1 receptor-associated kinase 3; ASRT5; FLJ13601; IRAK3; IRAKM,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Interleukin-1 receptor-associated kinase 3; ASRT5; FLJ13601; IRAK3; IRAKM,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000197,,,,,,,,,,,,,,,,,,,200200,,,,,,,,,IRAK3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000298,"[""COS-7 cell""]",,"African green monkey kidney derived from CV-1, a simian cell line (cercopithecus aethiops), by transformation with an origin-defective mutant of SV-40; cells were described to support the growth of SV-40 viruses.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0004055,,,,,,,,"African green monkey kidney derived from CV-1, a simian cell line (cercopithecus aethiops), by transformation with an origin-defective mutant of SV-40; cells were described to support the growth of SV-40 viruses.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000298,,,,,,,BrendaTissueOBO,COS7 cell,BTO:0000298,,,,,,,,,,,,,,,,,,,COS-7 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001120,"[""epithelial cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001120,,,,,,,BrendaTissueOBO,,BTO:0001120,,,,,,,,,,,,,,,,,,,epithelial cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100529,"[""Putative olfactory receptor 2I1""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100529,,,,https://pharos.nih.gov/idg/targets/Q8NGU4,,,,,,,,,,,,,OR2I1P,OR2I2|OR2I3P|OR2I4P,,Q8NGU4,,,,,,,,Putative olfactory receptor 2I1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003769,"[""A-498 cell""]",,Human kidney carcinoma cell line; established from the kidney carcinoma of a 52-year-old man in 1973.,false,,,http://purl.obolibrary.org/obo/BTO_0003192|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human kidney carcinoma cell line; established from the kidney carcinoma of a 52-year-old man in 1973.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003769,,,,,,,BrendaTissueOBO,A498 cell,BTO:0003769,,,,,,,,,,,,,,,,,,,A-498 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200542,"[""OR2M5 gene""]",,"An olfactory receptor 2M5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A3KFT3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2M5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A3KFT3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200542,,,,,,,,,,,,,,,,127059,OR2M5,OR2M5P,,,,,,,,,,OR2M5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2146,"[""ovary sarcoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1115|http://purl.obolibrary.org/obo/DOID_2394,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2146,,,,UMLS_CUI:C0280746|SNOMEDCT_US_2016_03_01:423627007|NCI:C8267,sarcoma of Ovary,,disease_ontology,,DOID:2146,,,,,,,,,,,,,,,,,,,ovary sarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100538,"[""Olfactory receptor 2L13""]",,"An olfactory receptor 2L13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N349] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2L13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N349] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100538,,,,https://pharos.nih.gov/idg/targets/Q8N349,,,,,,,,,,,,,OR2L13,OR2L14,,Q8N349,,,,,,,,Olfactory receptor 2L13,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004235,"[""uterine horn""]",,The portion of the uterus to which the intramural section of the uterine tube enters on either the right or left.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The portion of the uterus to which the intramural section of the uterine tube enters on either the right or left.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004235,,,,,,,BrendaTissueOBO,cornu uteri,BTO:0004235,,,,,,,,,,,,,,,,,,,uterine horn,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050043,"[""Israeli tick typhus""]",,"A spotted fever that has_material_basis_in Rickettsia conorii subsp israelensis, which is transmitted_by ticks (Rhipicephalus sanguineus). The infection has_symptom fever, has_symptom eschar, has_symptom regional adenopathy, and has_symptom maculopapular rash on extremities.",false,,,http://purl.obolibrary.org/obo/DOID_11104,,,,,,,,"A spotted fever that has_material_basis_in Rickettsia conorii subsp israelensis, which is transmitted_by ticks (Rhipicephalus sanguineus). The infection has_symptom fever, has_symptom eschar, has_symptom regional adenopathy, and has_symptom maculopapular rash on extremities.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050043,,,,,,,disease_ontology,Israeli spotted fever,DOID:0050043,http://purl.obolibrary.org/obo/doid#tick-borne_infectious_disease|http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease|http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,Israeli tick typhus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000337,"[""PHKG2 kinase domain""]",,"Phosphorylase kinase, gamma 2 (testis); GSD9C; PHKG2",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Phosphorylase kinase, gamma 2 (testis); GSD9C; PHKG2",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000337,,,,,,,,,,,,,,,,,,,200320,,,,,,,,,PHKG2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200136,"[""EPHB3 gene""]",,"Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400153,,,,,,,,"Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200136,,,,,,,,,,,,,,,,2049,EPHB3,ETK2|HEK2|TYRO6,,,,,,,,,,EPHB3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100090,"[""Macrophage colony-stimulating factor 1 receptor""]",,"A macrophage colony-stimulating factor 1 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P07333] |macrophage colony-stimulating factor 1 receptor (CSF1R)  with  no mutation  in a nonphosphorylated state|macrophage colony-stimulating factor 1 receptor (CSF1R-autoinhibited)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300141,,,,,,,,"A macrophage colony-stimulating factor 1 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P07333] |macrophage colony-stimulating factor 1 receptor (CSF1R)  with  no mutation  in a nonphosphorylated state|macrophage colony-stimulating factor 1 receptor (CSF1R-autoinhibited)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100090,,,,https://pharos.nih.gov/idg/targets/P07333,,,,,,,,,,,,,CSF1R,FMS,,P07333,,,,,,,,Macrophage colony-stimulating factor 1 receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000369,"[""THR670 in KIT(A829P)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000369,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR670 in KIT(A829P),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_66,"[""muscle tissue disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0080000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:66,,,,,,,disease_ontology,,DOID:66,,,,,,,,,,,,,,,,,,,muscle tissue disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_660,"[""adrenal cortex cancer""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3952|http://purl.obolibrary.org/obo/DOID_3953,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:660,,,DOID:3949,NCI:C9327|SNOMEDCT_US_2016_03_01:2227007|SNOMEDCT_US_2016_03_01:18365006|SNOMEDCT_US_2016_03_01:127022002|ICD10CM:C74.0|UMLS_CUI:C0001618|NCI:C2858|MESH:D000306|SNOMEDCT_US_2016_03_01:93664009|SNOMEDCT_US_2016_03_01:363479004|UMLS_CUI:C0346402|SNOMEDCT_US_2016_03_01:189645007|SNOMEDCT_US_2016_03_01:189648009|SNOMEDCT_US_2016_03_01:371964008,malignant Adrenocortical tumor|neoplasm of adrenal cortex (disorder)|malignant tumour of adrenal cortex|Adrenal cortical tumors NOS (disorder)|malignant neoplasm of adrenal cortex,,disease_ontology,,DOID:660,,,,,,,,,,,,,,,,,,,adrenal cortex cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_668,"[""myositis ossificans""]",,A myositis that is accompanied by ossification of muscle tissue or bony deposits in the muscles.,false,,,http://purl.obolibrary.org/obo/DOID_633,,,,,,,,A myositis that is accompanied by ossification of muscle tissue or bony deposits in the muscles.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:668,,,,UMLS_CUI:C0027122|SNOMEDCT_US_2016_03_01:156720008|SNOMEDCT_US_2016_03_01:203030008|SNOMEDCT_US_2016_03_01:44551007|NCI:C3253|MESH:D009221,Myisitis ossificans|Ossification - muscle,,disease_ontology,,DOID:668,,,,,,,,,,,,,,,,,,,myositis ossificans,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00000009,"[""drug target role""]",,"a role that is beared in a material entity, such as native (gene product) protein, protein complex, microorganism, DNA , etc., that physically interacts with a therapeutic or prophylactic drug (with some binding affinity) and where this physical interaction is (at least partially) the cause of a (detectable) clinical effect.",false,,,http://purl.obolibrary.org/obo/BFO_0000023,,,,,,,,"a role that is beared in a material entity, such as native (gene product) protein, protein complex, microorganism, DNA , etc., that physically interacts with a therapeutic or prophylactic drug (with some binding affinity) and where this physical interaction is (at least partially) the cause of a (detectable) clinical effect.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00000009,,,,,,,,,,,,,,,,,,,,,,,,,,,"Tudor Oprea, Stephan Schurer, Asiyah Yu Lin",drug target role,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004324,"[""osteoblast cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004324,,,,,,,BrendaTissueOBO,,BTO:0004324,,,,,,,,,,,,,,,,,,,osteoblast cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000345,"[""digestive gland""]",,"A gland, such as the liver or pancreas, that secretes into the alimentary canal substances necessary for digestion.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001488,,,,,,,,"A gland, such as the liver or pancreas, that secretes into the alimentary canal substances necessary for digestion.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000345,,,,,,,BrendaTissueOBO,,BTO:0000345,,,,,,,,,,,,,,,,,,,digestive gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100191,"[""Interleukin-1 receptor-associated kinase-like 2""]",,"An interleukin-1 receptor-associated kinase-like 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O43187] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300166,,,,,,,,"An interleukin-1 receptor-associated kinase-like 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O43187] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100191,,,,https://pharos.nih.gov/idg/targets/O43187,,,,,,,,,,,,,IRAK2,,,O43187,,,,,,,,Interleukin-1 receptor-associated kinase-like 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000046,"[""LEU123 in PIM3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000046,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU123 in PIM3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200246,"[""LPHN3 gene""]",,"A latrophilin-3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9HAR2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400039,,,,,,,,"A latrophilin-3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9HAR2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200246,,,,,,,,,,,,,,,,23284,LPHN3,KIAA0768|LEC3,,,,,,,,,,LPHN3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001131,"[""BHK cell""]",,Baby hamster kidney cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000067,,,,,,,,Baby hamster kidney cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001131,,,,,,,BrendaTissueOBO,,BTO:0001131,,,,,,,,,,,,,,,,,,,BHK cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002195,"[""vascular smooth muscle cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002195,,,,,,,BrendaTissueOBO,VSMC cell line,BTO:0002195,,,,,,,,,,,,,,,,,,,vascular smooth muscle cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_37098,"[""3-hydroxyoctanoic acid""]","3HO|C8H16O3|beta-OH-octanoic acid|3-hydroxycaprylic acid|3-hydroxy-octanoic acid|beta-hydroxyoctanoic acid|3-OH-caprylic acid|beta-OH-caprylic acid|3-OH octanoic acid|
InChI=1S/C8H16O3/c1-2-3-4-5-7(9)6-8(10)11/h7,9H,2-6H2,1H3,(H,10,11)
|NDPLAKGOSZHTPH-UHFFFAOYSA-N|beta-hydroxycaprylic acid|CCCCCC(O)CC(O)=O","
An 8-carbon, beta-hydroxy fatty acid which may be a marker for primary defects of beta-hydroxy fatty acid metabolism. Repeating unit of poly(3-hydroxyoctanoic acid), a biopolymer used by numerous bacterial species as carbon and energy reserves.
",false,,,http://purl.obolibrary.org/obo/CHEBI_33575,,,,,,,CiteXplore:3168281|CiteXplore:18422622|LIPID MAPS:LMFA01050021|CiteXplore:19047387|ChemIDplus:14292-27-4|Beilstein:1760767,"
An 8-carbon, beta-hydroxy fatty acid which may be a marker for primary defects of beta-hydroxy fatty acid metabolism. Repeating unit of poly(3-hydroxyoctanoic acid), a biopolymer used by numerous bacterial species as carbon and energy reserves.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,3-hydroxyoctanoic acid,,chebi_ontology,"3HO|C8H16O3|beta-OH-octanoic acid|3-hydroxycaprylic acid|3-hydroxy-octanoic acid|beta-hydroxyoctanoic acid|3-OH-caprylic acid|beta-OH-caprylic acid|3-OH octanoic acid|
InChI=1S/C8H16O3/c1-2-3-4-5-7(9)6-8(10)11/h7,9H,2-6H2,1H3,(H,10,11)
|NDPLAKGOSZHTPH-UHFFFAOYSA-N|beta-hydroxycaprylic acid|CCCCCC(O)CC(O)=O",,,CHEBI:37098,,,,,,,,,,,,,,,,,,,,,,,CHEBI:37098,,,,,3-hydroxyoctanoic acid,,CHEBI:37098,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11213,"[""acute contagious conjunctivitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_11184,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11213,,,,SNOMEDCT_US_2016_03_01:399047004|SNOMEDCT_US_2016_03_01:399219006|NCI:C35704|SNOMEDCT_US_2016_03_01:17482009|SNOMEDCT_US_2016_03_01:267734002|SNOMEDCT_US_2016_03_01:240066005|SNOMEDCT_US_2016_03_01:155162002|UMLS_CUI:C1313983,Pinkeye|Contagious opthalmia|Pink eye,,disease_ontology,,DOID:11213,,,,,,,,,,,,,,,,,,,acute contagious conjunctivitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200417,"[""OR52E4 gene""]",,"An olfactory receptor 52E4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 52E4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200417,,,,,,,,,,,,,,,,390081,OR52E4,,,,,,,,,,,OR52E4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100043,"[""Voltage-dependent L-type calcium channel subunit alpha-1F""]",,"A voltage-dependent L-type calcium channel subunit alpha-1F that is encoded in the genome of human. [PRO:WCB, UniProtKB:O60840] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300386,,,,,,,,"A voltage-dependent L-type calcium channel subunit alpha-1F that is encoded in the genome of human. [PRO:WCB, UniProtKB:O60840] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100043,,,,https://pharos.nih.gov/idg/targets/O60840,,,,,,,,,,,,,CACNA1F,CACNAF1,,O60840,,,,,,,,Voltage-dependent L-type calcium channel subunit alpha-1F,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100219,"[""Calcium/calmodulin-dependent protein kinase type ii subunit beta""]",,"A calcium/calmodulin-dependent protein kinase type II subunit beta that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13554] |calcium/calmodulin-dependent protein kinase type ii subunit beta (CAMK2B)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300172,,,,,,,,"A calcium/calmodulin-dependent protein kinase type II subunit beta that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13554] |calcium/calmodulin-dependent protein kinase type ii subunit beta (CAMK2B)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100219,,,,https://pharos.nih.gov/idg/targets/Q13554,,,,,,,,,,,,,CAMK2B,CAM2|CAMK2|CAMKB,,Q13554,,,,,,,,Calcium/calmodulin-dependent protein kinase type ii subunit beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001238,"[""Sertoli cell""]",,"Any of the elongated, striated cells of the seminiferous tubules of the testis, to which spermatids attach for nourishment during spermatogenesis.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002315,,,,,,,,"Any of the elongated, striated cells of the seminiferous tubules of the testis, to which spermatids attach for nourishment during spermatogenesis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001238,,,,,,,BrendaTissueOBO,,BTO:0001238,,,,,,,,,,,,,,,,,,,Sertoli cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100312,"[""Tyrosine-protein kinase mer""]",,"A tyrosine-protein kinase Mer that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q12866] |tyrosine-protein kinase mer (MERTK)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300189,,,,,,,,"A tyrosine-protein kinase Mer that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q12866] |tyrosine-protein kinase mer (MERTK)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100312,,,,https://pharos.nih.gov/idg/targets/Q12866,,,,,,,,,,,,,MERTK,MER,,Q12866,,,,,,,,Tyrosine-protein kinase mer,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200654,"[""OR6C1 gene""]",,"An olfactory receptor 6C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200654,,,,,,,,,,,,,,,,390321,OR6C1,,,,,,,,,,,OR6C1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100317,"[""Mitogen-activated protein kinase 4""]",,"A mitogen-activated protein kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P31152] |mitogen-activated protein kinase 4 (ERK4)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300292,,,,,,,,"A mitogen-activated protein kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P31152] |mitogen-activated protein kinase 4 (ERK4)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100317,,,,https://pharos.nih.gov/idg/targets/P31152,,,,,,,,,,,,,MAPK4,ERK4|PRKM4,,P31152,,,,,,,,Mitogen-activated protein kinase 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100476,"[""Serine/threonine-protein kinase sik2""]",,"A serine/threonine-protein kinase SIK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H0K1] |serine/threonine-protein kinase sik2 (SIK2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300314,,,,,,,,"A serine/threonine-protein kinase SIK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H0K1] |serine/threonine-protein kinase sik2 (SIK2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100476,,,,https://pharos.nih.gov/idg/targets/Q9H0K1,,,,,,,,,,,,,SIK2,KIAA0781|QIK|SNF1LK2,,Q9H0K1,,,,,,,,Serine/threonine-protein kinase sik2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200537,"[""TRIB3 gene""]",,"The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400237,,,,,,,,"The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200537,,,,,,,,,,,,,,,,57761,TRIB3,C20orf97|NIPK|SKIP3,,,,,,,,,,TRIB3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200606,"[""NADK2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200606,,,,,,,,,,,,,,,,,,,,,,,,,,,,NADK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12995,"[""conduct disorder""]",,A specific developmental disorder marked by a pattern of repetitive behavior wherein the rights of others or social norms are violated.,false,,,http://purl.obolibrary.org/obo/DOID_0060038,,,,,,,,A specific developmental disorder marked by a pattern of repetitive behavior wherein the rights of others or social norms are violated.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12995,,,,EFO:0004216|MESH:D019955|SNOMEDCT_US_2016_03_01:192603009|NCI:C89329|SNOMEDCT_US_2016_03_01:192104004|SNOMEDCT_US_2016_03_01:430909002|SNOMEDCT_US_2016_03_01:268785008|SNOMEDCT_US_2016_03_01:192106002|SNOMEDCT_US_2016_03_01:268782006|SNOMEDCT_US_2016_03_01:192597006|UMLS_CUI:C0149654|ICD10CM:F91|ICD9CM:312.9|SNOMEDCT_US_2016_03_01:154945001|ICD10CM:F91.9,,,disease_ontology,,DOID:12995,,,,,,,,,,,,,,,,,,,conduct disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100418,"[""Serine/threonine-protein kinase pim-2""]",,"A serine/threonine-protein kinase Pim-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P1W9] |serine/threonine-protein kinase pim-2 (PIM2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300207,,,,,,,,"A serine/threonine-protein kinase Pim-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P1W9] |serine/threonine-protein kinase pim-2 (PIM2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100418,,,,https://pharos.nih.gov/idg/targets/Q9P1W9,,,,,,,,,,,,,PIM2,,,Q9P1W9,,,,,,,,Serine/threonine-protein kinase pim-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100129,"[""Adhesion G-protein coupled receptor F1""]",,"A G-protein coupled receptor 110 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5T601] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,"A G-protein coupled receptor 110 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5T601] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100129,,,,https://pharos.nih.gov/idg/targets/Q5T601,,,,,,,,,,,,,GPR110,ADGRF1|PGR19,,Q5T601,,,,,,,,Adhesion G-protein coupled receptor F1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200618,"[""OR5C1 gene""]",,"An olfactory receptor 5C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200618,,,,,,,,,,,,,,,,392391,OR5C1,OR5C2P,,,,,,,,,,OR5C1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200060,"[""CCR8 gene""]",,"A C-C chemokine receptor type 8 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51685] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400095,,,,,,,,"A C-C chemokine receptor type 8 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51685] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200060,,,,,,,,,,,,,,,,1237,CCR8,CKRL1|CMKBR8|CMKBRL2,,,,,,,,,,CCR8 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200167,"[""ITPR3 gene""]",,"This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400354,,,,,,,,"This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200167,,,,,,,,,,,,,,,,3710,ITPR3,,,,,,,,,,,ITPR3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5782,"[""tympanic membrane disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5100,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5782,,,,ICD10CM:H73.90|SNOMEDCT_US_2016_03_01:21426000|SNOMEDCT_US_2016_03_01:194326008|ICD9CM:384.9|ICD10CM:H73.9|UMLS_CUI:C0041825,,,disease_ontology,,DOID:5782,,,,,,,,,,,,,,,,,,,tympanic membrane disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300235,"[""TLK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300235,,,,,,,,,,,,,,,,,,,,,,,,,,,,TLK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200525,"[""OR2G3 gene""]",,"An olfactory receptor 2G3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2G3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200525,,,,,,,,,,,,,,,,81469,OR2G3,,,,,,,,,,,OR2G3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001834,"[""sympathetic chain""]",,Either of the pair of ganglionated longitudinal cords of the sympathetic nervous system of which one is situated on each side of the spinal column.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Either of the pair of ganglionated longitudinal cords of the sympathetic nervous system of which one is situated on each side of the spinal column.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001834,,,,,,,BrendaTissueOBO,sympathetic trunk,BTO:0001834,,,,,,,,,,,,,,,,,,,sympathetic chain,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400275,"[""Meta subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400174,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400275,,,,,,,,,,,,,,,,,,,,,,,,,,,,Meta subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000431,"[""TESK1 kinase domain""]",,Testis-specific kinase 1; TESK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Testis-specific kinase 1; TESK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000431,,,,,,,,,,,,,,,,,,,200432,,,,,,,,,TESK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200511,"[""OR2A5 gene""]",,"An olfactory receptor 2A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R48] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R48] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200511,,,,,,,,,,,,,,,,393046,OR2A5,OR2A26|OR2A8,,,,,,,,,,OR2A5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100166,"[""Inositol 1,4,5-trisphosphate receptor type 2""]",,"An inositol 1,4,5-trisphosphate receptor type 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14571] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300354,,,,,,,,"An inositol 1,4,5-trisphosphate receptor type 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14571] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100166,,,,https://pharos.nih.gov/idg/targets/Q14571,,,,,,,,,,,,,ITPR2,,,Q14571,,,,,,,,"Inositol 1,4,5-trisphosphate receptor type 2",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400360,"[""Transient receptor potential calcium channel (TRP-CC) family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400360,,,,,,,,,,,,,,,,,,,,,,,,,,,,Transient receptor potential calcium channel (TRP-CC) family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100457,"[""Rho-associated protein kinase 2""]",,"rho-associated protein kinase 2 (ROCK2)  with  no mutation  in a nonphosphorylated state|A rho-associated protein kinase 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O75116] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300313,,,,,,,,"rho-associated protein kinase 2 (ROCK2)  with  no mutation  in a nonphosphorylated state|A rho-associated protein kinase 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O75116] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100457,,,,https://pharos.nih.gov/idg/targets/O75116,,,,,,,,,,,,,ROCK2,KIAA0619,,O75116,,,,,,,,Rho-associated protein kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100188,"[""Potassium voltage-gated channel subfamily B member 2""]",,"A voltage-gated potassium channel KCNB2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q92953] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300540,,,,,,,,"A voltage-gated potassium channel KCNB2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q92953] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100188,,,,https://pharos.nih.gov/idg/targets/Q92953,,,,,,,,,,,,,KCNB2,,,Q92953,,,,,,,,Potassium voltage-gated channel subfamily B member 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050432,"[""Asperger syndrome""]",,"An autism spectrum disorder that is characterized by significant difficulties in social interaction, along with restricted and repetitive patterns of behavior and interests. It differs from other autism spectrum disorders by its relative preservation of linguistic and cognitive development.",false,,,http://purl.obolibrary.org/obo/DOID_0060041,,,,,,,,"An autism spectrum disorder that is characterized by significant difficulties in social interaction, along with restricted and repetitive patterns of behavior and interests. It differs from other autism spectrum disorders by its relative preservation of linguistic and cognitive development.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050432,,,,MESH:D020817|OMIM:608631|SNOMEDCT_US_2016_03_01:192586006|ORDO:1162|OMIM:300494|ICD10CM:F84.5|OMIM:300497|UMLS_CUI:C0236792|OMIM:609954|NCI:C97159|OMIM:608638|SNOMEDCT_US_2016_03_01:23560001|SNOMEDCT_US_2016_03_01:154879004|OMIM:608781,,,disease_ontology,,DOID:0050432,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,Asperger syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050434,"[""Andersen-Tawil syndrome""]",,"A long QT syndrome that has_material_basis_in autosomal dominant inheritance of a mutation in the KCNJ2 gene which disrupts the rhythm of the heart's lower chambers (ventricular arrhythmia) and results_in an unusually small lower jaw (micrognathia), low-set ears, and an abnormal curvature of the fingers called clinodactyly.",false,,,http://purl.obolibrary.org/obo/DOID_2843,,,,,,,,"A long QT syndrome that has_material_basis_in autosomal dominant inheritance of a mutation in the KCNJ2 gene which disrupts the rhythm of the heart's lower chambers (ventricular arrhythmia) and results_in an unusually small lower jaw (micrognathia), low-set ears, and an abnormal curvature of the fingers called clinodactyly.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050434,,,,OMIM:170390|SNOMEDCT_US_2016_03_01:422348008|ORDO:37553|NCI:C84559|UMLS_CUI:C1563715|MESH:D050030,Long QT syndrome 7|Andersen syndrome |ATS|ANDERSEN CARDIODYSRHYTHMIC PERIODIC PARALYSIS|Potassium-Sensitive Cardiodysrhythmic Type|LQT7,,disease_ontology,,DOID:0050434,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Andersen-Tawil syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050437,"[""Danon disease""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_3211,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050437,,,,NCI:C84735|SNOMEDCT_US_2016_03_01:419097006|OMIM:300257|UMLS_CUI:C0878677|MESH:D052120,ANTOPOL DISEASE|PSEUDOGLYCOGENOSIS II,,disease_ontology,,DOID:0050437,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Danon disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050439,"[""Usher syndrome""]",,A syndrome characterized by a combination of hearing loss and visual impairment.,false,,,http://purl.obolibrary.org/obo/DOID_0050737,,,,,,,,A syndrome characterized by a combination of hearing loss and visual impairment.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050439,,,,UMLS_CUI:C1568249|OMIM:PS276900|SNOMEDCT_US_2016_03_01:73119000|UMLS_CUI:C1568248|UMLS_CUI:C2931205|MESH:D052245|NCI:C85217|SNOMEDCT_US_2016_03_01:57838006|ORDO:886|UMLS_CUI:C0271097,,,disease_ontology,,DOID:0050439,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [LS].",,Usher syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050431,"[""arrhythmogenic right ventricular cardiomyopathy""]",,"An intrinsic cardiomyopathy that is characterized by hypokinetic areas involving the free wall of the right ventricle, with fibrofatty replacement of the right ventricular myocardium, with associated arrhythmias originating in the right ventricle.",false,,,http://purl.obolibrary.org/obo/DOID_0060036,,,,,,,,"An intrinsic cardiomyopathy that is characterized by hypokinetic areas involving the free wall of the right ventricle, with fibrofatty replacement of the right ventricular myocardium, with associated arrhythmias originating in the right ventricle.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050431,,,,SNOMEDCT_US_2016_03_01:281170005|ORDO:247|SNOMEDCT_US_2016_03_01:253528005|NCI:C84571|MESH:D019571|ORDO:217656|UMLS_CUI:C0349788|OMIM:PS107970,arrhythmogenic right ventricular dysplasia/cardiomyopathy|ARVC cardiomyopathy|ARVD|ARVC|arrhythmogenic right ventricular dysplasia,,disease_ontology,,DOID:0050431,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,arrhythmogenic right ventricular cardiomyopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050430,"[""multiple endocrine neoplasia type 2A""]",,"An autosomal dominant disease characterized by medullary carcinoma of the thyroid, pheochromocytoma, hyperparathyroidism, and occasionally cutaneous lichen amyloidosis.",false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,"An autosomal dominant disease characterized by medullary carcinoma of the thyroid, pheochromocytoma, hyperparathyroidism, and occasionally cutaneous lichen amyloidosis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050430,,,,UMLS_CUI:C0025268|ICD9CM:258.02|SNOMEDCT_US_2016_03_01:61808009|ORDO:247698|NCI:C3226|ICD10CM:E31.22|MESH:D018813|OMIM:171400,multiple endocrine neoplasia II|MEN2A|Sipple syndrome,,disease_ontology,,DOID:0050430,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,multiple endocrine neoplasia type 2A,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000403,"[""mastocytoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000403,,,,,,,BrendaTissueOBO,,BTO:0000403,,,,,,,,,,,,,,,,,,,mastocytoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000166,"[""cecum""]",,"The first part of the large intestine, forming a dilated pouch into which open the ileum, colon, and appendix vermiformis.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The first part of the large intestine, forming a dilated pouch into which open the ileum, colon, and appendix vermiformis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000166,,,,,,,BrendaTissueOBO,blindgut|caecum|intestinum caecum|intestinum crassum caecum|blind intestine|intestinum crassum cecum,BTO:0000166,,,,,,,,,,,,,,,,,,,cecum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001209,"[""umbilical cord cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001975,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001209,,,,,,,BrendaTissueOBO,,BTO:0001209,,,,,,,,,,,,,,,,,,,umbilical cord cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000235,"[""basal ganglion""]",,"Any of four deeply placed masses of gray matter (as the amygdala) in each cerebral hemisphere. Location: The basal ganglion is located deep within the cerebral hemispheres in the telencephalon region of the brain. It consists of the corpus stratium, subthalamic nucleus and the substantia nigra.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000497,,,,,,,,"Any of four deeply placed masses of gray matter (as the amygdala) in each cerebral hemisphere. Location: The basal ganglion is located deep within the cerebral hemispheres in the telencephalon region of the brain. It consists of the corpus stratium, subthalamic nucleus and the substantia nigra.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000235,,,,,,,BrendaTissueOBO,basal nucleus,BTO:0000235,,,,,,,,,,,,,,,,,,,basal ganglion,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100420,"[""Serine/threonine-protein kinase pink1, mitochondrial""]",,"A serine/threonine-protein kinase PINK1, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BXM7] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300208,,,,,,,,"A serine/threonine-protein kinase PINK1, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BXM7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100420,,,,https://pharos.nih.gov/idg/targets/Q9BXM7,,,,,,,,,,,,,PINK1,,,Q9BXM7,,,,,,,,"Serine/threonine-protein kinase pink1, mitochondrial",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300406,"[""CNGB1 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300343,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300406,,,,,,,,,,,,,,,,,,,,,,,,,,,,CNGB1 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100016,"[""Neuronal acetylcholine receptor subunit beta-3""]",,"A neuronal acetylcholine receptor subunit beta-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q05901] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300500,,,,,,,,"A neuronal acetylcholine receptor subunit beta-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q05901] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100016,,,,https://pharos.nih.gov/idg/targets/Q05901,,,,,,,,,,,,,CHRNB3,,,Q05901,,,,,,,,Neuronal acetylcholine receptor subunit beta-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02390003,"[""Orphan GPCR""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300001,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02390003,,,,,,,,,,,,,,,,,,,,,,,,,,,,Orphan GPCR,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001277,"[""spermatozoon""]",,A motile male gamete of an animal usually with rounded or elongate head and a long posterior flagellum.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000535,,,,,,,,A motile male gamete of an animal usually with rounded or elongate head and a long posterior flagellum.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001277,,,,,,,BrendaTissueOBO,zoosperm|spermatozoan|mature sperm cell|male gamete|sperm cell,BTO:0001277,,,,,,,,,,,,,,,,,,,spermatozoon,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000363,"[""PKMYT1 kinase domain""]",,"Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; Protein kinase, membrane associated tyrosine/threonine 1; DKFZp547K1610; FLJ20093; MYT1",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; Protein kinase, membrane associated tyrosine/threonine 1; DKFZp547K1610; FLJ20093; MYT1",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000363,,,,,,,,,,,,,,,,,,,200346,,,,,,,,,PKMYT1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100087,"[""Endothelin b receptor""]",,"An endothelin B receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P24530] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300099,,,,,,,,"An endothelin B receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P24530] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100087,,,,https://pharos.nih.gov/idg/targets/P24530,,,,,,,,,,,,,EDNRB,ETRB,,P24530,,,,,,,,Endothelin b receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000296,"[""MST1R kinase domain""]",,Macrophage stimulating 1 receptor (c-met-related tyrosine kinase); CD136; CDw136; MST1R; PTK8; RON,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Macrophage stimulating 1 receptor (c-met-related tyrosine kinase); CD136; CDw136; MST1R; PTK8; RON,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000296,,,,,,,,,,,,,,,,,,,200273,,,,,,,,,MST1R kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200229,"[""TK1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200229,,,,,,,,,,,,,,,,7083,TK1,,,,,,,,,,,TK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300256,"[""TAIRE subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300136,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300256,,,,,,,,,,,,,,,,,,,,,,,,,,,,TAIRE subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400167,"[""JAKA family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400167,,,,,,,,,,,,,,,,,,,,,,,,,,,,JAKA family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002398,"[""prostate epithelium cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001019|http://purl.obolibrary.org/obo/BTO_0001120,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002398,,,,,,,BrendaTissueOBO,,BTO:0002398,,,,,,,,,,,,,,,,,,,prostate epithelium cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400281,"[""MSK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400178,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400281,,,,,,,,,,,,,,,,,,,,,,,,,,,,MSK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001202,"[""saliva""]",,"A slightly alkaline secretion of water, mucin, protein, salts, and often a starch-splitting enzyme, as ptyalin, that is secreted into the mouth by salivary glands, lubricates ingested food, and often begins the breakdown of starches.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A slightly alkaline secretion of water, mucin, protein, salts, and often a starch-splitting enzyme, as ptyalin, that is secreted into the mouth by salivary glands, lubricates ingested food, and often begins the breakdown of starches.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001202,,,,,,,BrendaTissueOBO,,BTO:0001202,,,,,,,,,,,,,,,,,,,saliva,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100469,"[""Tyrosine-protein kinase sgk223""]",,A tyrosine-protein kinase SgK223 that is encoded in the genome of human. ,false,,,http://www.drugtargetontology.org/dto/DTO_03300204,,,,,,,,A tyrosine-protein kinase SgK223 that is encoded in the genome of human. ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100469,,,,https://pharos.nih.gov/idg/targets/Q86YV5,,,,,,,,,,,,,SGK223,,,Q86YV5,,,,,,,,Tyrosine-protein kinase sgk223,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200432,"[""OR52N4 gene""]",,"An olfactory receptor 52N4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 52N4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200432,,,,,,,,,,,,,,,,390072,OR52N4,,,,,,,,,,,OR52N4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100258,"[""Ribosomal protein s6 kinase beta-2""]",,"A ribosomal protein S6 kinase beta-2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9UBS0] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300282,,,,,,,,"A ribosomal protein S6 kinase beta-2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9UBS0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100258,,,,https://pharos.nih.gov/idg/targets/Q9UBS0,,,,,,,,,,,,,RPS6KB2,STK14B,,Q9UBS0,,,,,,,,Ribosomal protein s6 kinase beta-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300284,"[""MLK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300165,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300284,,,,,,,,,,,,,,,,,,,,,,,,,,,,MLK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100087,"[""Cyclic nucleotide-gated cation channel alpha-3""]",,"A cyclic nucleotide-gated cation channel alpha-3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q16281] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300404,,,,,,,,"A cyclic nucleotide-gated cation channel alpha-3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q16281] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100087,,,,https://pharos.nih.gov/idg/targets/Q16281,,,,,,,,,,,,,CNGA3,CNCG3,,Q16281,,,,,,,,Cyclic nucleotide-gated cation channel alpha-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80309,"[""Neuropeptide K""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16095,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80309,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80309,,,,,Neuropeptide K,,CHEBI:80309,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000447,"[""TTK kinase domain""]",,TTK protein kinase; CT96; ESK; FLJ38280; MPS1; MPS1L1; PYT; TTK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,TTK protein kinase; CT96; ESK; FLJ38280; MPS1; MPS1L1; PYT; TTK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000447,,,,,,,,,,,,,,,,,,,200448,,,,,,,,,TTK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100298,"[""Putative olfactory receptor 10d3""]",,"An olfactory receptor 958 that is encoded in the genome of human. [OMA:HUMAN05487, PRO:DNx] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 958 that is encoded in the genome of human. [OMA:HUMAN05487, PRO:DNx] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100298,,,,https://pharos.nih.gov/idg/targets/Q8NH80,,,,,,,,,,,,,OR10D3,OR10D3P,,Q8NH80,,,,,,,,Putative olfactory receptor 10d3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000183,"[""HCK kinase domain""]",,Hemopoietic cell kinase; HCK; JTK9,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Hemopoietic cell kinase; HCK; JTK9,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000183,,,,,,,,,,,,,,,,,,,200185,,,,,,,,,HCK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100398,"[""[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial""]",,"A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16654] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300131,,,,,,,,"A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16654] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100398,,,,https://pharos.nih.gov/idg/targets/Q16654,,,,,,,,,,,,,PDK4,PDHK4,,Q16654,,,,,,,,"[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100611,"[""Nucleoside diphosphate kinase 3""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100611,,,,,,,,,,,,,,,,,NME3,,,Q13232,,,,,,,,Nucleoside diphosphate kinase 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200819,"[""VIPR2 gene""]",,"A vasoactive intestinal polypeptide receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41587] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400003,,,,,,,,"A vasoactive intestinal polypeptide receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41587] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200819,,,,,,,,,,,,,,,,7434,VIPR2,VIP2R,,,,,,,,,,VIPR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200204,"[""GPR62 gene""]",,"A G-protein coupled receptor 62 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BZJ7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 62 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BZJ7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200204,,,,,,,,,,,,,,,,118442,GPR62,,,,,,,,,,,GPR62 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400279,"[""PKC iota subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400175,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400279,,,,,,,,,,,,,,,,,,,,,,,,,,,,PKC iota subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000717,"[""pericardium""]",,1: The conical sac of serous membrane that encloses the heart and the roots of the great blood vessels of vertebrates. 2: A cavity or space that contains the heart of an invertebrate and in arthropods is a part of the hemocoel.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,1: The conical sac of serous membrane that encloses the heart and the roots of the great blood vessels of vertebrates. 2: A cavity or space that contains the heart of an invertebrate and in arthropods is a part of the hemocoel.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000717,,,,,,,BrendaTissueOBO,pericardial sac,BTO:0000717,,,,,,,,,,,,,,,,,,,pericardium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400434,"[""KCNJ8 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400434,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ8 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100453,"[""Receptor-interacting serine/threonine-protein kinase 4""]",,"receptor-interacting serine/threonine-protein kinase 4 (RIPK4)  with  no mutation  in a nonphosphorylated state|A receptor-interacting serine/threonine-protein kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P57078] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300124,,,,,,,,"receptor-interacting serine/threonine-protein kinase 4 (RIPK4)  with  no mutation  in a nonphosphorylated state|A receptor-interacting serine/threonine-protein kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P57078] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100453,,,,https://pharos.nih.gov/idg/targets/P57078,,,,,,,,,,,,,RIPK4,ANKRD3|DIK,,P57078,,,,,,,,Receptor-interacting serine/threonine-protein kinase 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217460,"[""Thyroid hormone receptors gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00200002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217460,,,,,,,,,,,,,,,,,,,,,,,,,,,,Thyroid hormone receptors gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5409,"[""lung small cell carcinoma""]",,A lung carcinoma that has_material_basis_in primitive-appearing cells that are smaller than normal cells.,false,,,http://purl.obolibrary.org/obo/DOID_0050685|http://purl.obolibrary.org/obo/DOID_3905,,,,,,,,A lung carcinoma that has_material_basis_in primitive-appearing cells that are smaller than normal cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5409,,,,SNOMEDCT_US_2016_03_01:254633006|SNOMEDCT_US_2016_03_01:254632001|OMIM:182280|MESH:D055752|KEGG:05222|NCI:C4917|UMLS_CUI:C0149925,Oat cell carcinoma of lung (disorder)|small cell neuroendocrine carcinoma of lung|SCLC|small cell carcinoma of lung (disorder),,disease_ontology,small cell carcinoma of lung,DOID:5409,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,lung small cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100199,"[""Potassium voltage-gated channel subfamily E member 4""]",,"A potassium voltage-gated channel subfamily E member 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WWG9] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300445,,,,,,,,"A potassium voltage-gated channel subfamily E member 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WWG9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100199,,,,https://pharos.nih.gov/idg/targets/Q8WWG9,,,,,,,,,,,,,KCNE4,,,Q8WWG9,,,,,,,,Potassium voltage-gated channel subfamily E member 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100065,"[""Cadherin egf lag seven-pass g-type receptor 2""]",,"A cadherin EGF LAG seven-pass G-type receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HCU4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300032,,,,,,,,"A cadherin EGF LAG seven-pass G-type receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HCU4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100065,,,,https://pharos.nih.gov/idg/targets/Q9HCU4,,,,,,,,,,,,,CELSR2,CDHF10|EGFL2|KIAA0279|MEGF3,,Q9HCU4,,,,,,,,Cadherin egf lag seven-pass g-type receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100171,"[""Tyrosine-protein kinase hck""]",,"tyrosine-protein kinase hck (HCK)  with  no mutation  in a nonphosphorylated state|A tyrosine-protein kinase HCK that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08631] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300132,,,,,,,,"tyrosine-protein kinase hck (HCK)  with  no mutation  in a nonphosphorylated state|A tyrosine-protein kinase HCK that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08631] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100171,,,,https://pharos.nih.gov/idg/targets/P08631,,,,,,,,,,,,,HCK,,,P08631,,,,,,,,Tyrosine-protein kinase hck,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100011,"[""Serine/threonine-protein kinase receptor r3""]",,"A serine/threonine-protein kinase receptor R3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P37023] |serine/threonine-protein kinase receptor r3 (ACVRL1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300246,,,,,,,,"A serine/threonine-protein kinase receptor R3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P37023] |serine/threonine-protein kinase receptor r3 (ACVRL1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100011,,,,https://pharos.nih.gov/idg/targets/P37023,,,,,,,,,,,,,ACVRL1,ACVRLK1|ALK1,,P37023,,,,,,,,Serine/threonine-protein kinase receptor r3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200516,"[""OR2B8P gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200516,,,,,,,,,,,,,,,,65944,OR2B8P,OR2B8,,,,,,,,,,OR2B8P gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000126,"[""EGFR(L747-T751del,Sins) kinase domain""]",,"Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000126,,,,,,,,,,,,,,,,,,,200128,,,,,,,,,"EGFR(L747-T751del,Sins) kinase domain",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100360,"[""Serine/threonine-protein kinase nek6""]",,"serine/threonine-protein kinase nek6 (NEK6)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase Nek6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HC98] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300197,,,,,,,,"serine/threonine-protein kinase nek6 (NEK6)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase Nek6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HC98] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100360,,,,https://pharos.nih.gov/idg/targets/Q9HC98,,,,,,,,,,,,,NEK6,,,Q9HC98,,,,,,,,Serine/threonine-protein kinase nek6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391007,"[""Mevalonate kinase subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391026,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391007,,,,,,,,,,,,,,,,,,,,,,,,,,,,Mevalonate kinase subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004053,"[""umbilical cord blood""]",,Blood from the umbilical cord of a newborn baby. This blood contains high concentrations of stem cells.,false,,,http://purl.obolibrary.org/obo/BTO_0000089|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Blood from the umbilical cord of a newborn baby. This blood contains high concentrations of stem cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004053,,,,,,,BrendaTissueOBO,cord blood,BTO:0004053,,,,,,,,,,,,,,,,,,,umbilical cord blood,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000140,"[""bone""]",,"The hard form of connective tissue that constitutes the majority of the skeleton of most vertebrates; it consists of an organic component (the cells and matrix) and an inorganic, or mineral, component; the matrix contains a framework of collagenous fibers and is impregnated with the mineral component, chiefly calcium phosphate (85 per cent) and calcium carbonate (10 per cent), which imparts the quality of rigidity to bone.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000421|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,,"The hard form of connective tissue that constitutes the majority of the skeleton of most vertebrates; it consists of an organic component (the cells and matrix) and an inorganic, or mineral, component; the matrix contains a framework of collagenous fibers and is impregnated with the mineral component, chiefly calcium phosphate (85 per cent) and calcium carbonate (10 per cent), which imparts the quality of rigidity to bone.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000140,,,,,,,BrendaTissueOBO,osseous tissue,BTO:0000140,,,,,,,,,,,,,,,,,,,bone,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2529,"[""splenic disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_75,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2529,,,DOID:0000815,ICD9CM:289.50|SNOMEDCT_US_2016_03_01:191385006|SNOMEDCT_US_2016_03_01:191381002|SNOMEDCT_US_2016_03_01:154839008|ICD10CM:D73.9|UMLS_CUI:C0037997|SNOMEDCT_US_2016_03_01:58381000|SNOMEDCT_US_2016_03_01:51244008|SNOMEDCT_US_2016_03_01:267570002|MESH:D013158|ICD10CM:D73|NCI:C35823,Dyssplenism|Spleen disease,,disease_ontology,,DOID:2529,,,,,,,,,,,,,,,,,,,splenic disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2998,"[""testicular cancer""]",,A male reproductive system cancer that is located_in the testicles.,false,,,http://purl.obolibrary.org/obo/DOID_3856,,,,,,,,A male reproductive system cancer that is located_in the testicles.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2998,,,DOID:5554|DOID:12231,ICD10CM:C62.90|SNOMEDCT_US_2016_03_01:269472003|NCI:C7251|UMLS_CUI:C1333010|SNOMEDCT_US_2016_03_01:94087009|MESH:D013736|ICD10CM:C62|ICD10CM:C62.9|ICD9CM:186|SNOMEDCT_US_2016_03_01:363449006|OMIM:273300|SNOMEDCT_US_2016_03_01:236778008|NCI:C3404|UMLS_CUI:C0039590|SNOMEDCT_US_2016_03_01:188228003|NCI:C5053|UMLS_CUI:C0153594|SNOMEDCT_US_2016_03_01:126900000,testicular tumor (disorder)|neoplasm of testis (disorder)|testis cancer|pediatric testicular neoplasm|testis neoplasm|childhood neoplasm of the testis|testicular tumor,,disease_ontology,,DOID:2998,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,testicular cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100257,"[""Glutamate receptor ionotropic, NMDA 2A""]",,"A glutamate receptor ionotropic, NMDA 2A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q12879] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300455,,,,,,,,"A glutamate receptor ionotropic, NMDA 2A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q12879] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100257,,,,https://pharos.nih.gov/idg/targets/Q12879,,,,,,,,,,,,,GRIN2A,NMDAR2A,,Q12879,,,,,,,,"Glutamate receptor ionotropic, NMDA 2A",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100071,"[""Chloride channel protein clc-kb""]",,"A chloride channel protein ClC-Kb that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51801] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300394,,,,,,,,"A chloride channel protein ClC-Kb that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51801] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100071,,,,https://pharos.nih.gov/idg/targets/P51801,,,,,,,,,,,,,CLCNKB,,,P51801,,,,,,,,Chloride channel protein clc-kb,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100683,"[""Olfactory receptor 7G2""]",,"An olfactory receptor 7G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG99] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 7G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG99] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100683,,,,https://pharos.nih.gov/idg/targets/Q8NG99,,,,,,,,,,,,,OR7G2,,,Q8NG99,,,,,,,,Olfactory receptor 7G2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5082,"[""liver cirrhosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_409,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5082,,,,SNOMEDCT_US_2016_03_01:235891006|SNOMEDCT_US_2016_03_01:155809006|UMLS_CUI:C0023890|SNOMEDCT_US_2016_03_01:266537000|EFO:0001422|NCI:C2951|SNOMEDCT_US_2016_03_01:197309008|ICD10CM:K74.60|SNOMEDCT_US_2016_03_01:19943007|MESH:D008103,Cirrhosis|cirrhosis of liver,,disease_ontology,,DOID:5082,,,,,,,,,,,,,,,,,,,liver cirrhosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13300,"[""Scheuermann's disease""]",,An osteochondrosis that results_in abnormal bone growth and curvature located_in thoracic vertebral column.,false,,,http://purl.obolibrary.org/obo/DOID_8125,,,,,,,,An osteochondrosis that results_in abnormal bone growth and curvature located_in thoracic vertebral column.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13300,,,,SNOMEDCT_US_2016_03_01:203361005|OMIM:181440|MESH:D012544|ICD10CM:M42.0|UMLS_CUI:C0036310|NCI:C34999|SNOMEDCT_US_2016_03_01:53406005|SNOMEDCT_US_2016_03_01:203415006|SNOMEDCT_US_2016_03_01:156816000|SNOMEDCT_US_2016_03_01:203362003|SNOMEDCT_US_2016_03_01:203364002|ICD9CM:732.0|ICD10CM:M42.00,Sherman's Disease|Juvenile osteochondrosis of spine|Juvenile osteochondritis of the spine|Juvenile osteochondrosis of Scheurermann|Scheuermann's kyphosis,Scheuermann disease,disease_ontology,,DOID:13300,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Scheuermann's disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200384,"[""PAK1 gene""]",,"This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400303,,,,,,,,"This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200384,,,,,,,,,,,,,,,,5058,PAK1,,,,,,,,,,,PAK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4838,"[""myoepithelial carcinoma""]",,A carcinoma that derives_from myoepithelial cells.,false,,,http://purl.obolibrary.org/obo/DOID_305,,,,,,,,A carcinoma that derives_from myoepithelial cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4838,,,,SNOMEDCT_US_2016_03_01:128884000|UMLS_CUI:C0334699|NCI:C7596|SNOMEDCT_US_2016_03_01:24292006,,,disease_ontology,,DOID:4838,,,,,,,,,,,,,,,,,,,myoepithelial carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200243,"[""PRKCG gene""]",,"Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400276,,,,,,,,"Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200243,,,,,,,,,,,,,,,,5582,PRKCG,PKCG,,,,,,,,,,PRKCG gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100447,"[""Olfactory receptor 5ak2""]",,"An olfactory receptor 5AK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH90] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5AK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH90] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100447,,,,https://pharos.nih.gov/idg/targets/Q8NH90,,,,,,,,,,,,,OR5AK2,,,Q8NH90,,,,,,,,Olfactory receptor 5ak2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200579,"[""OR4D5 gene""]",,"An olfactory receptor 4D5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4D5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200579,,,,,,,,,,,,,,,,219875,OR4D5,,,,,,,,,,,OR4D5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200109,"[""GABRA3 gene""]",,"GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400508,,,,,,,,"GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200109,,,,,,,,,,,,,,,,2556,GABRA3,,,,,,,,,,,GABRA3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200444,"[""OR56B4 gene""]",,"An olfactory receptor 56B4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH76] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 56B4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH76] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200444,,,,,,,,,,,,,,,,196335,OR56B4,,,,,,,,,,,OR56B4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_116390,"[""1-chloro-2-[2-(2-methoxy-4-methylphenoxy)ethoxy]-4-methylbenzene""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:116390,,,,,,,,,,,,,,,,,,,,,,,,,,,,1-chloro-2-[2-(2-methoxy-4-methylphenoxy)ethoxy]-4-methylbenzene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100234,"[""Potassium voltage-gated channel subfamily KQT member 3""]",,A voltage-gated potassium channel subunit KCNQ3 that is encoded in the genome of human. [] ,false,,,http://www.drugtargetontology.org/dto/DTO_01300563,,,,,,,,A voltage-gated potassium channel subunit KCNQ3 that is encoded in the genome of human. [] ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100234,,,,https://pharos.nih.gov/idg/targets/O43525,,,,,,,,,,,,,KCNQ3,,,O43525,,,,,,,,Potassium voltage-gated channel subfamily KQT member 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3156,"[""incontinentia pigmenti achromians""]",,,false,,,http://purl.obolibrary.org/obo/DOID_37,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3156,,,,SNOMEDCT_US_2016_03_01:806001|SNOMEDCT_US_2016_03_01:48543002|UMLS_CUI:C0022283|SNOMEDCT_US_2016_03_01:367520004|SNOMEDCT_US_2016_03_01:218358001|MESH:D010859|SNOMEDCT_US_2016_03_01:254816001|NCI:C7582|SNOMEDCT_US_2016_03_01:254202001,nevus of Ito|Ito's nevus|Bloch-Siemans syndrome|Incontinentia pigmenti syndrome|Incontinentia pigmenti achromians syndrome|Hypomelanosis of Ito,,disease_ontology,,DOID:3156,,,,,,,,,,,,,,,,,,,incontinentia pigmenti achromians,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14291,"[""LEOPARD syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14291,,,,OMIM:151100|MESH:D044542|SNOMEDCT_US_2016_03_01:111306001|UMLS_CUI:C0175704|OMIM:613707|NCI:C84820|OMIM:611554,Capute-Rimoin-Konigsmark-Esterly-Richardson syndrome|Lentiginosis profusa syndrome|Multiple lentigines syndrome (disorder)|Moynahan syndrome|Progressive cardiomyopathic lentiginosis|Gorlin syndrome II|Generalized lentiginosis (disorder)|Cardiocutaneous syndrome,,disease_ontology,LEOPARD syndrome,DOID:14291,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,LEOPARD syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100385,"[""Olfactory receptor 51A4""]",,"An olfactory receptor 51A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 51A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100385,,,,https://pharos.nih.gov/idg/targets/Q8NGJ6,,,,,,,,,,,,,OR51A4,,,Q8NGJ6,,,,,,,,Olfactory receptor 51A4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000021,"[""head muscle""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001103,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000021,,,,,,,BrendaTissueOBO,,BTO:0000021,,,,,,,,,,,,,,,,,,,head muscle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000142,"[""EPHB2 kinase domain""]",,Ephrin type-B receptor 2; CAPB; DRT; EK5; EPHB2; EPHT3; ERK; Hek5; MGC87492; PCBC; Tyro5,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Ephrin type-B receptor 2; CAPB; DRT; EK5; EPHB2; EPHT3; ERK; Hek5; MGC87492; PCBC; Tyro5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000142,,,,,,,,,,,,,,,,,,,200144,,,,,,,,,EPHB2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_6498,"[""LXA4""]","
(5S,6R,7E,9E,11Z,13E,15S)-5,6,15-trihydroxy-7,9,11,13-eicosatetraenoic acid
|IXAQOQZEOGMIQS-SSQFXEBMSA-N|5S,6S-Lipoxin A4|5S,6R-LipoxinA4|
5(S),6(R),15(S)-trihydroxyeicosa-7E,9E,11Z,13E-tetraenoic acid
|
5S,6R,15S-trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid
|
InChI=1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18+,19-/m0/s1
|
(7E,9E,11Z,13E)-(5S,6R,15S)-5,6,15-Trihydroxyicosa-7,9,11,13-tetraenoic acid
|
(5S,6R,7E,9E,11Z,13E,15S)-5,6,15-trihydroxyeicosa-7,9,11,13-tetraenoic acid
|
5S,6R,15S-Trihydroxy-7E,9E,11Z,13E-eicosatetraenoate
|
5S,6R,15S-Trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid
|C20H32O5|
(7E,9E,11Z,13E)-(5S,6R,15S)-5,6,15-Trihydroxyicosa-7,9,11,13-tetraenoate
|6R-LXA4|LXA4|
CCCCC[C@H](O)\C=C\C=C/C=C/C=C/[C@@H](O)[C@@H](O)CCCC(O)=O
|
(5S,6R,15S)-trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid
","
A C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds.
",false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,CiteXplore:15320881|CiteXplore:16005201|CiteXplore:12920210|LIPID MAPS:LMFA03040001|CiteXplore:20950211|KEGG COMPOUND:C06314|CiteXplore:8422907|CiteXplore:20435922|CiteXplore:16141446|CiteXplore:20833483|CiteXplore:16613568|CiteXplore:20802423|CiteXplore:2713393|CiteXplore:16550298|CiteXplore:21263017|HMDB:HMDB04385|CiteXplore:1910866|CiteXplore:8690917|CiteXplore:21359215|CiteXplore:20959513|Reaxys:4698639|KEGG COMPOUND:89663-86-5,"
A C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,"lipoxin A4|
(5S,6R,7E,9E,11Z,13E,15S)-5,6,15-trihydroxyicosa-7,9,11,13-tetraenoic acid
|Lipoxin A4",,chebi_ontology,"
(5S,6R,7E,9E,11Z,13E,15S)-5,6,15-trihydroxy-7,9,11,13-eicosatetraenoic acid
|IXAQOQZEOGMIQS-SSQFXEBMSA-N|5S,6S-Lipoxin A4|5S,6R-LipoxinA4|
5(S),6(R),15(S)-trihydroxyeicosa-7E,9E,11Z,13E-tetraenoic acid
|
5S,6R,15S-trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid
|
InChI=1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18+,19-/m0/s1
|
(7E,9E,11Z,13E)-(5S,6R,15S)-5,6,15-Trihydroxyicosa-7,9,11,13-tetraenoic acid
|
(5S,6R,7E,9E,11Z,13E,15S)-5,6,15-trihydroxyeicosa-7,9,11,13-tetraenoic acid
|
5S,6R,15S-Trihydroxy-7E,9E,11Z,13E-eicosatetraenoate
|
5S,6R,15S-Trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid
|C20H32O5|
(7E,9E,11Z,13E)-(5S,6R,15S)-5,6,15-Trihydroxyicosa-7,9,11,13-tetraenoate
|6R-LXA4|LXA4|
CCCCC[C@H](O)\C=C\C=C/C=C/C=C/[C@@H](O)[C@@H](O)CCCC(O)=O
|
(5S,6R,15S)-trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid
",,,CHEBI:6498,,,,,,,,,,,,,,,,,,,,,,,CHEBI:6498,,,,,lipoxin A4|LXA4,,CHEBI:6498,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400556,"[""Kv12.3/KCNH4 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400448,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400556,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv12.3/KCNH4 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004537,"[""cortical collecting duct cell""]",,The cortical collecting ducts receive filtrate from multiple initial collecting tubules and descend into the renal medulla to form medullary collecting ducts.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The cortical collecting ducts receive filtrate from multiple initial collecting tubules and descend into the renal medulla to form medullary collecting ducts.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004537,mgr,2010-02-16T10:29:18Z,,,,,BrendaTissueOBO,CCD cell,BTO:0004537,,,,,,,,,,,,,,,,,,,cortical collecting duct cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400020,"[""Acetylcholine receptor (muscarinic) gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400020,,,,,,,,,,,,,,,,,,,,,,,,,,,,Acetylcholine receptor (muscarinic) gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000086,"[""LEU93 in DAPK3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000086,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU93 in DAPK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100499,"[""Serine/threonine-protein kinase 25""]",,"A serine/threonine-protein kinase 25 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00506] |serine/threonine-protein kinase 25 (YSK1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300297,,,,,,,,"A serine/threonine-protein kinase 25 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00506] |serine/threonine-protein kinase 25 (YSK1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100499,,,,https://pharos.nih.gov/idg/targets/O00506,,,,,,,,,,,,,STK25,SOK1|YSK1,,O00506,,,,,,,,Serine/threonine-protein kinase 25,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200502,"[""OR1N1 gene""]",,"An olfactory receptor 1N1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1N1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200502,,,,,,,,,,,,,,,,138883,OR1N1,OR1N3,,,,,,,,,,OR1N1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300098,"[""Endothelin type A""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300038,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300098,,,,,,,,,,,,,,,,,,,,,,,,,,,,Endothelin type A,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400069,"[""Neuropeptide FF/neuropeptide AF receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400069,,,,,,,,,,,,,,,,,,,,,,,,,,,,Neuropeptide FF/neuropeptide AF receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4676,"[""uremia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1074,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4676,,,,SNOMEDCT_US_2016_03_01:197656003|ICD10CM:N19|MESH:D014511|UMLS_CUI:C0041948|SNOMEDCT_US_2016_03_01:266616000|SNOMEDCT_US_2016_03_01:44730006,UREMIA OF renal ORIGIN,,disease_ontology,,DOID:4676,,,,,,,,,,,,,,,,,,,uremia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2893,"[""cervix carcinoma""]",,A cervical cancer that is located_in the cervix uteri or located_in the cervical area and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.,false,,,http://purl.obolibrary.org/obo/DOID_4362,,,,,,,,A cervical cancer that is located_in the cervix uteri or located_in the cervical area and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2893,,,,SNOMEDCT_US_2016_03_01:154525002|UMLS_CUI:C0302592|SNOMEDCT_US_2016_03_01:93752005|SNOMEDCT_US_2016_03_01:154522004|SNOMEDCT_US_2016_03_01:285432005|SNOMEDCT_US_2016_03_01:188174005|NCI:C9039|SNOMEDCT_US_2016_03_01:269599004|SNOMEDCT_US_2016_03_01:269596006,carcinoma of cervix (disorder)|carcinoma OF CERVIX|carcinoma of the Cervix Uteri|carcinoma cervix uteri|cancer of cervix,,disease_ontology,,DOID:2893,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,cervix carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200078,"[""CLCN7 gene""]",,"The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400401,,,,,,,,"The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200078,,,,,,,,,,,,,,,,1186,CLCN7,,,,,,,,,,,CLCN7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050073,"[""invasive aspergillosis""]",,"An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by Aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. Clinical symptoms include pulmonary nodules and hemorrhage.",false,,,http://purl.obolibrary.org/obo/DOID_13564,,,,,,,,"An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by Aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. Clinical symptoms include pulmonary nodules and hemorrhage.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050073,,,,,,,disease_ontology,,DOID:0050073,,,,,,,,,,,,,,,,,,,invasive aspergillosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6552,"[""gastric small cell carcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0050685|http://purl.obolibrary.org/obo/DOID_5517,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6552,,,,NCI:C6764|UMLS_CUI:C1333788,small cell carcinoma of stomach,,disease_ontology,,DOID:6552,,,,,,,,,,,,,,,,,,,gastric small cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200129,"[""EPHA5 gene""]",,"This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400153,,,,,,,,"This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200129,,,,,,,,,,,,,,,,2044,EPHA5,BSK|EHK1|HEK7,,,,,,,,,,EPHA5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000030,"[""[125I][Tyr26]galanin (human)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000030,,,,,,,,,,,,,,,,,,,,,,,,,,,,[125I][Tyr26]galanin (human),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_63000004,"[""PI3_PI4_kinase""]",,"A Pfam protein family that is a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns).The pathway, with oncogene PIK3CA and tumor suppressor PTEN, is implicated in insensitivity of cancer tumors to insulin and IGF1, and in calorie restriction.",false,,,http://www.drugtargetontology.org/dto/DTO_63000000,,,,,,,,"A Pfam protein family that is a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns).The pathway, with oncogene PIK3CA and tumor suppressor PTEN, is implicated in insensitivity of cancer tumors to insulin and IGF1, and in calorie restriction.",http://pfam.xfam.org/family/PI3_PI4_kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_63000004,,,,,,,,,,,,,,,,,,,,,,,,,,,,PI3_PI4_kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100375,"[""Olfactory receptor 2T35""]",,"An olfactory receptor 2T35 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2T35 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100375,,,,https://pharos.nih.gov/idg/targets/Q8NGX2,,,,,,,,,,,,,OR2T35,,,Q8NGX2,,,,,,,,Olfactory receptor 2T35,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200052,"[""CCR10 gene""]",,"A C-C chemokine receptor type 10 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46092] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400095,,,,,,,,"A C-C chemokine receptor type 10 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46092] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200052,,,,,,,,,,,,,,,,2826,CCR10,GPR2,,,,,,,,,,CCR10 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200392,"[""PASK gene""]",,"This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400305,,,,,,,,"This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200392,,,,,,,,,,,,,,,,23178,PASK,KIAA0135,,,,,,,,,,PASK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300354,"[""Ryanodine-inositol 1,4,5-triphosphate receptor calcium channel (rir-cac) family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300354,,,,,,,,,,,,,,,,,,,,,,,,,,,,"Ryanodine-inositol 1,4,5-triphosphate receptor calcium channel (rir-cac) family",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100020,"[""Acetylcholine receptor subunit epsilon""]",,"An acetylcholine receptor subunit epsilon that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q04844] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300504,,,,,,,,"An acetylcholine receptor subunit epsilon that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q04844] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100020,,,,https://pharos.nih.gov/idg/targets/Q04844,,,,,,,,,,,,,CHRNE,ACHRE,,Q04844,,,,,,,,Acetylcholine receptor subunit epsilon,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400315,"[""SLK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400187,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400315,,,,,,,,,,,,,,,,,,,,,,,,,,,,SLK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100104,"[""FXYD domain-containing ion transport regulator 6""]",,"An FXYD domain-containing ion transport regulator 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H0Q3] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300349,,,,,,,,"An FXYD domain-containing ion transport regulator 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H0Q3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100104,,,,https://pharos.nih.gov/idg/targets/Q9H0Q3,,,,,,,,,,,,,FXYD6,,,Q9H0Q3,,,,,,,,FXYD domain-containing ion transport regulator 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200265,"[""P2RX2 gene""]",,"The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_01400364,,,,,,,,"The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200265,,,,,,,,,,,,,,,,22953,P2RX2,P2X2,,,,,,,,,,P2RX2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002144,"[""acute lymphoblastic leukemia cell line""]",,"Lymphocytic leukemia cell line that is marked by an abnormal increase in the number of lymphoblasts, that is characterized by rapid onset and progression of symptoms which include fever, anemia, pallor, fatigue, appetite loss, bleeding, thrombocytopenia, granulocytopenia, bone and joint pain, and enlargement of the lymph nodes, liver, and spleen, and that occurs chiefly during childhood.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000739,,,,,,,,"Lymphocytic leukemia cell line that is marked by an abnormal increase in the number of lymphoblasts, that is characterized by rapid onset and progression of symptoms which include fever, anemia, pallor, fatigue, appetite loss, bleeding, thrombocytopenia, granulocytopenia, bone and joint pain, and enlargement of the lymph nodes, liver, and spleen, and that occurs chiefly during childhood.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002144,,,,,,,BrendaTissueOBO,ALL cell line,BTO:0002144,,,,,,,,,,,,,,,,,,,acute lymphoblastic leukemia cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100134,"[""Ephrin type-b receptor 1""]",,"ephrin type-b receptor 1 (EPHB1)  with  no mutation  in a nonphosphorylated state|An ephrin type-B receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54762] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300153,,,,,,,,"ephrin type-b receptor 1 (EPHB1)  with  no mutation  in a nonphosphorylated state|An ephrin type-B receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54762] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100134,,,,https://pharos.nih.gov/idg/targets/P54762,,,,,,,,,,,,,EPHB1,ELK|EPHT2|HEK6|NET,,P54762,,,,,,,,Ephrin type-b receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300556,"[""Kv12.3/KCNH4 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300448,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300556,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv12.3/KCNH4 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000309,"[""NEK1 kinase domain""]",,NIMA (never in mitosis gene a)-related kinase 1; DKFZp686D06121; DKFZp686K12169; KIAA1901; MGC138800; NEK1; NY-REN-55,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,NIMA (never in mitosis gene a)-related kinase 1; DKFZp686D06121; DKFZp686K12169; KIAA1901; MGC138800; NEK1; NY-REN-55,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000309,,,,,,,,,,,,,,,,,,,200286,,,,,,,,,NEK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300264,"[""CHK1 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300116,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300264,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHK1 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001489,"[""whole body""]",,The main part of an animal body especially as distinguished from limbs and head.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000042,,,,,,,,The main part of an animal body especially as distinguished from limbs and head.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001489,,,,,,,BrendaTissueOBO,Koerper,BTO:0001489,,,,,,,,,,,,,,,,,,,whole body,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100384,"[""Olfactory receptor 51A2""]",,"An olfactory receptor 51A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 51A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100384,,,,https://pharos.nih.gov/idg/targets/Q8NGJ7,,,,,,,,,,,,,OR51A2,,,Q8NGJ7,,,,,,,,Olfactory receptor 51A2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_52449,"[""5-oxo-ETE""]","5-Oxo-icosa-6,8,11,14-tetraenoic acid|5-keto-ETE|5-Oxoicosatetraenoic acid|318.219|5-oxo-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid|5-Oxoeicosatetraenoic acid|InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h6-7,9-10,12-14,16H,2-5,8,11,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,13-12-,16-14+|C20H30O3|MEASLHGILYBXFO-XTDASVJISA-N|5-OxoETE|318.45040|5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid|5-oxo, 6t,8c,11c,14c-20:4|eicosa-5,8,12,14-tetraenoic acid|CCCCC\C=C/C\C=C/C\C=C/C=C/C(=O)CCCC(O)=O|0|(6E,8Z,11Z,14Z)-5-Oxoicosa-6,8,11,14-tetraenoic acid|5-ketoeicosatetraenoic acid","An oxoicosatetraenoic acid having a 5-oxo group; and (6E)-, (8Z), (11Z)- and (14Z)-double bonds.",false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,PMID:19450703|KEGG:C14732|PMID:8906847|Reaxys:6213921|PMID:3599023|PMID:16159627|HMDB:HMDB10217|LIPID_MAPS_instance:LMFA03060011|PMID:15893379,"An oxoicosatetraenoic acid having a 5-oxo group; and (6E)-, (8Z), (11Z)- and (14Z)-double bonds.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:120616|CHEBI:34460|CHEBI:60950|CHEBI:52287,,"(6E,8Z,11Z,14Z)-5-oxoicosa-6,8,11,14-tetraenoic acid",,chebi_ontology,"5-Oxo-icosa-6,8,11,14-tetraenoic acid|5-keto-ETE|5-Oxoicosatetraenoic acid|318.219|5-oxo-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid|5-Oxoeicosatetraenoic acid|InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h6-7,9-10,12-14,16H,2-5,8,11,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,13-12-,16-14+|C20H30O3|MEASLHGILYBXFO-XTDASVJISA-N|5-OxoETE|318.45040|5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid|5-oxo, 6t,8c,11c,14c-20:4|eicosa-5,8,12,14-tetraenoic acid|CCCCC\C=C/C\C=C/C\C=C/C=C/C(=O)CCCC(O)=O|0|(6E,8Z,11Z,14Z)-5-Oxoicosa-6,8,11,14-tetraenoic acid|5-ketoeicosatetraenoic acid",,,CHEBI:52449,,,,,,,,,,,,,,,,,,,,,,,CHEBI:52449,,,,,5-oxo-ETE,,CHEBI:52449,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300236,"[""TOPK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300236,,,,,,,,,,,,,,,,,,,,,,,,,,,,TOPK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002180,"[""184B5 cell""]",,The 184A1N4 and 184B5 cell lines are nontumorigenic cell lines derived from primary cultures of HMECs that were immortalized with benzo(a)pyrene.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The 184A1N4 and 184B5 cell lines are nontumorigenic cell lines derived from primary cultures of HMECs that were immortalized with benzo(a)pyrene.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002180,,,,,,,BrendaTissueOBO,,BTO:0002180,,,,,,,,,,,,,,,,,,,184B5 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200196,"[""GPR3 gene""]",,"A G-protein coupled receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46089] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46089] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200196,,,,,,,,,,,,,,,,2827,GPR3,ACCA,,,,,,,,,,GPR3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4074,"[""pancreatic adenocarcinoma""]",,A pancreatic carcinoma that derives_from epithelial cells of glandular origin.,false,,,http://purl.obolibrary.org/obo/DOID_4905|http://purl.obolibrary.org/obo/DOID_26|http://purl.obolibrary.org/obo/DOID_299,,,,,,,,A pancreatic carcinoma that derives_from epithelial cells of glandular origin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4074,,,,NCI:C8294|UMLS_CUI:C0281361|SNOMEDCT_US_2016_03_01:700423003,pancreas adenocarcinoma,,disease_ontology,adenocarcinoma of the pancreas,DOID:4074,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,pancreatic adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001873,"[""lens epithelium""]",,Cuboidal epithelium covering the lens.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000416,,,,,,,,Cuboidal epithelium covering the lens.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001873,,,,,,,BrendaTissueOBO,ocular lens epithelium,BTO:0001873,,,,,,,,,,,,,,,,,,,lens epithelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000346,"[""PIK3CA(H1047L) kinase domain""]",,"Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000346,,,,,,,,,,,,,,,,,,,200328,,,,,,,,,PIK3CA(H1047L) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200309,"[""TMC1 gene""]",,"This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, it is known to be required for normal function of cochlear hair cells. Mutations in this gene have been associated with progressive postlingual hearing loss and profound prelingual deafness. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400372,,,,,,,,"This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, it is known to be required for normal function of cochlear hair cells. Mutations in this gene have been associated with progressive postlingual hearing loss and profound prelingual deafness. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200309,,,,,,,,,,,,,,,,117531,TMC1,,,,,,,,,,,TMC1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200370,"[""SCYL1 gene""]",,"This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400199,,,,,,,,"This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200370,,,,,,,,,,,,,,,,57410,SCYL1,CVAK90|GKLP|NTKL,,,,,,,,,,SCYL1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400525,"[""GLRA1 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400409,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400525,,,,,,,,,,,,,,,,,,,,,,,,,,,,GLRA1 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100408,"[""Olfactory receptor 52a1""]",,"An olfactory receptor 52A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UKL2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 52A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UKL2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100408,,,,https://pharos.nih.gov/idg/targets/Q9UKL2,,,,,,,,,,,,,OR52A1,,,Q9UKL2,,,,,,,,Olfactory receptor 52a1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3650,"[""lactic acidosis""]",,An acquired metabolic disease that has_material_basis_in low pH in body tissues and blood accompanied by the buildup of lactate especially D-lactate.,false,,,http://purl.obolibrary.org/obo/DOID_0060158,,,,,,,,An acquired metabolic disease that has_material_basis_in low pH in body tissues and blood accompanied by the buildup of lactate especially D-lactate.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3650,,,,ICD10CM:E87.2|UMLS_CUI:C0001125|MESH:D000140|SNOMEDCT_US_2016_03_01:91273001|NCI:C98969,,,disease_ontology,,DOID:3650,,,,,,,,,,,,,,,,,,,lactic acidosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100257,"[""Mas-related g-protein coupled receptor member d""]",,"A mas-related G-protein coupled receptor D that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDS7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300063,,,,,,,,"A mas-related G-protein coupled receptor D that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDS7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100257,,,,https://pharos.nih.gov/idg/targets/Q8TDS7,,,,,,,,,,,,,MRGPRD,MRGD,,Q8TDS7,,,,,,,,Mas-related g-protein coupled receptor member d,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0080132,"[""Sengers syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_700,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0080132,,,,OMIM:212350,mitochondrial DNA depletion syndrome 10,,,,,,,,,,,,,,,,,,,,,,,Sengers syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200357,"[""OR14L1P gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200357,,,,,,,,,,,,,,,,127617,OR14L1P,OR5AV1P,,,,,,,,,,OR14L1P gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3350,"[""mesenchymal cell neoplasm""]",,"A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from embryonic connective tissue that is capable of developing into connective tissue, such as bone, and cartilage, the lymphatic system, and the circulatory system.",false,,,http://purl.obolibrary.org/obo/DOID_0050687,,,,,,,,"A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from embryonic connective tissue that is capable of developing into connective tissue, such as bone, and cartilage, the lymphatic system, and the circulatory system.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3350,,,DOID:1630,NCI:C7059|UMLS_CUI:C1332517|NCI:C6587|UMLS_CUI:C1334699,benign miscellaneous mesenchymal tumor|mesenchymal tumor,,disease_ontology,,DOID:3350,,,,,,,,,,,,,,,,,,,mesenchymal cell neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000333,"[""THR315 in ABL1(M351T)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000333,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR315 in ABL1(M351T),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005053,"[""midgut epithelium""]",,"For example the midgut epithelium of Wirenia argentea Odhner Mollusca, Solenogastres) is composed of two cell types: dorsal ciliary cells and digestive cells.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"For example the midgut epithelium of Wirenia argentea Odhner Mollusca, Solenogastres) is composed of two cell types: dorsal ciliary cells and digestive cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005053,XPMUser,2011-03-05T09:11:07Z,,,,,BrendaTissueOBO,,BTO:0005053,,,,,,,,,,,,,,,,,,,midgut epithelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1943,"[""telogen effluvium""]",,,false,,,http://purl.obolibrary.org/obo/DOID_987,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1943,,,,UMLS_CUI:C0263518|SNOMEDCT_US_2016_03_01:39479004|ICD10CM:L65.0|NCI:C112200|SNOMEDCT_US_2016_03_01:201147004|ICD9CM:704.02,Telogen effluvium (disorder),,disease_ontology,,DOID:1943,,,,,,,,,,,,,,,,,,,telogen effluvium,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200804,"[""TAAR5 gene""]",,"A trace amine-associated receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14804] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A trace amine-associated receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14804] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200804,,,,,,,,,,,,,,,,9038,TAAR5,PNR,,,,,,,,,,TAAR5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000774,"[""lymphoblastoma cell""]",,A cell of any of several diseases of lymph nodes marked by the formation of tumorous masses composed of mature or immature lymphocytes.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A cell of any of several diseases of lymph nodes marked by the formation of tumorous masses composed of mature or immature lymphocytes.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000774,,,,,,,BrendaTissueOBO,,BTO:0000774,,,,,,,,,,,,,,,,,,,lymphoblastoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200486,"[""SRPK1 gene""]",,"This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.[provided by RefSeq, Jul 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400226,,,,,,,,"This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.[provided by RefSeq, Jul 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200486,,,,,,,,,,,,,,,,6732,SRPK1,,,,,,,,,,,SRPK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000792,"[""urinary bladder cancer cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000096,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000792,,,,,,,BrendaTissueOBO,urinary bladder carcinoma cell line,BTO:0000792,,,,,,,,,,,,,,,,,,,urinary bladder cancer cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000381,"[""THR692 in EPHA2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000381,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR692 in EPHA2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002928,"[""adult stem cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002928,,,,,,,BrendaTissueOBO,adulte Stammzelllinie,BTO:0002928,,,,,,,,,,,,,,,,,,,adult stem cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000056,"[""LEU147 in RSK2(Kin.Dom.1-N-terminal)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000056,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU147 in RSK2(Kin.Dom.1-N-terminal),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100728,"[""P2Y purinoceptor 4""]",,"A P2Y purinoceptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51582] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300100,,,,,,,,"A P2Y purinoceptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51582] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100728,,,,https://pharos.nih.gov/idg/targets/P51582,,,,,,,,,,,,,P2RY4,NRU,,P51582,,,,,,,,P2Y purinoceptor 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1319,"[""brain cancer""]",,A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain.,false,,,http://purl.obolibrary.org/obo/DOID_3620|http://purl.obolibrary.org/obo/DOID_936,,,,,,,,A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1319,,,DOID:6649|DOID:911|DOID:2126|DOID:2125|DOID:3543,SNOMEDCT_US_2016_03_01:126952004|SNOMEDCT_US_2016_03_01:428061005|SNOMEDCT_US_2016_03_01:93727008|UMLS_CUI:C0220624|SNOMEDCT_US_2016_03_01:254935002|NCI:C5115|SNOMEDCT_US_2016_03_01:189537005|ICD10CM:C71.9|SNOMEDCT_US_2016_03_01:188305001|NCI:C4952|ICD9CM:239.6|SNOMEDCT_US_2016_03_01:275464006|NCI:C4954|UMLS_CUI:C0750974|CSP:2006-2736|UMLS_CUI:C0750979|SNOMEDCT_US_2016_03_01:188279009|UMLS_CUI:C1334557|ICD9CM:191.9|SNOMEDCT_US_2016_03_01:269610005|ICD10CM:C71|NCI:C3568|NCI:C7710|NCI:C2907|MESH:D001932|UMLS_CUI:C0006118|ICD9CM:191|UMLS_CUI:C0153633|SNOMEDCT_US_2016_03_01:154550004|SNOMEDCT_US_2016_03_01:363356001,"neoplasm of unspecified nature of brain (disorder)|primary brain neoplasm|adult malignant brain neoplasm|primary malignant neoplasm of brain (disorder)|malignant tumor of adult brain|neoplasm of unspecified nature of brain|primary brain tumor|malignant primary brain tumor|BT - Brain tumour|adult brain tumor|brain neoplasm|neoplasm of brain (disorder)|malignant tumor of Brain|brain neoplasm, adult|malignant primary brain neoplasm|malignant brain tumour|tumor of the Brain",,disease_ontology,,DOID:1319,http://purl.obolibrary.org/obo/doid#DO_cancer_slim|http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,brain cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3393,"[""coronary artery disease""]",,An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles.,false,,,http://purl.obolibrary.org/obo/DOID_0050828,,,,,,,,An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3393,,,DOID:9420|DOID:3394|DOID:3363|DOID:10506,SNOMEDCT_US_2016_03_01:414545008|MESH:D003327|SNOMEDCT_US_2016_03_01:266290000|SNOMEDCT_US_2016_03_01:41702007|SNOMEDCT_US_2016_03_01:413838009|OMIM:608901|OMIM:610947|MESH:D003324|SNOMEDCT_US_2016_03_01:195540001|SNOMEDCT_US_2016_03_01:155315001|UMLS_CUI:C0010054|OMIM:608320|SNOMEDCT_US_2016_03_01:414795007|OMIM:610938|EFO:0001645|SNOMEDCT_US_2016_03_01:155316000|MESH:D017202|OMIM:614466|SNOMEDCT_US_2016_03_01:32598000|SNOMEDCT_US_2016_03_01:266291001|OMIM:612030|UMLS_CUI:C0264694|ICD10CM:I25.1|NCI:C50625|SNOMEDCT_US_2016_03_01:53741008|ICD10CM:I25|SNOMEDCT_US_2016_03_01:155303000|ICD10CM:K76.1|UMLS_CUI:C0010068|OMIM:608316|SNOMEDCT_US_2016_03_01:194878003|ICD9CM:414.9|SNOMEDCT_US_2016_03_01:443502000|OMIM:607339|SNOMEDCT_US_2016_03_01:413844008|NCI:C35505|SNOMEDCT_US_2016_03_01:233822007|UMLS_CUI:C0151744|SNOMEDCT_US_2016_03_01:194795001|OMIM:300464|SNOMEDCT_US_2016_03_01:271430002|SNOMEDCT_US_2016_03_01:155322009|SNOMEDCT_US_2016_03_01:266231003|OMIM:611139|SNOMEDCT_US_2016_03_01:155318004|SNOMEDCT_US_2016_03_01:194841001|ICD9CM:414.0|SNOMEDCT_US_2016_03_01:84537008|ICD9CM:410-414.99|OMIM:614293|ICD10CM:I25.9|SNOMEDCT_US_2016_03_01:2610009|OMIM:608318|ICD10CM:I20-I25|ICD10CM:I25.10|SNOMEDCT_US_2016_03_01:194852007,CHD (coronary heart disease)|coronary arteriosclerosis|Coronary disease|coronary heart disease,,disease_ontology,,DOID:3393,,,,,,,,,,,,,,,,,Xref MGI.,,coronary artery disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_92,"[""speech disorder""]",,A communication disorder that involves difficulty with the act of speech production.,false,,,http://purl.obolibrary.org/obo/DOID_2033,,,,,,,,A communication disorder that involves difficulty with the act of speech production.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:92,,,,MESH:D013064|NCI:C5041|UMLS_CUI:C0037822,,,disease_ontology,,DOID:92,,,,,,,,,,,,,,,,,,,speech disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2449,"[""acromegaly""]",,A disease of metabolism that has_material_basis_in excessive growth hormone production which results_in enlargement located_in limb.,false,,,http://purl.obolibrary.org/obo/DOID_2444,,,,,,,,A disease of metabolism that has_material_basis_in excessive growth hormone production which results_in enlargement located_in limb.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2449,,,,MESH:D000172|NCI:C84533|UMLS_CUI:C0001206|SNOMEDCT_US_2016_03_01:154698000|SNOMEDCT_US_2016_03_01:267480001|SNOMEDCT_US_2016_03_01:74107003,,,disease_ontology,,DOID:2449,,,,,,,,,,,,,,,,,,,acromegaly,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4138,"[""bile duct disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_9741,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4138,,,,UMLS_CUI:C0005395|SNOMEDCT_US_2016_03_01:118926004|SNOMEDCT_US_2016_03_01:197455006|MESH:D001649|NCI:C96716,bile duct disorder NOS (disorder)|disorder of bile duct (disorder),,disease_ontology,,DOID:4138,,,,,,,,,,,,,,,,,,,bile duct disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100401,"[""Olfactory receptor 51J1""]",,"An olfactory receptor 51J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H342] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 51J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H342] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100401,,,,https://pharos.nih.gov/idg/targets/Q9H342,,,,,,,,,,,,,OR51J1,OR51J1P|OR51J2,,Q9H342,,,,,,,,Olfactory receptor 51J1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002424,"[""mesothelioma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002424,,,,,,,BrendaTissueOBO,,BTO:0002424,,,,,,,,,,,,,,,,,,,mesothelioma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300496,"[""Alpha-7/CHRNA7 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300496,,,,,,,,,,,,,,,,,,,,,,,,,,,,Alpha-7/CHRNA7 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000134,"[""PrRP-31""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000134,,,,,,,,,,,,,,,,,,,,,,,,,,,,PrRP-31,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200644,"[""OR5R1 gene""]",,"An olfactory receptor 5R1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH85] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5R1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH85] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200644,,,,,,,,,,,,,,,,219479,OR5R1,OR5R1P,,,,,,,,,,OR5R1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100770,"[""Somatostatin receptor type 1""]",,"A somatostatin receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30872] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A somatostatin receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30872] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100770,,,,https://pharos.nih.gov/idg/targets/P30872,,,,,,,,,,,,,SSTR1,,,P30872,,,,,,,,Somatostatin receptor type 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004439,"[""hypopharyngeal carcinoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000790,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004439,Marion,2010-02-02T03:17:50Z,,,,,BrendaTissueOBO,,BTO:0004439,,,,,,,,,,,,,,,,,,,hypopharyngeal carcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000185,"[""HIPK2 kinase domain""]",,Homeodomain interacting protein kinase 2; DKFZp686K02111; FLJ23711; HIPK2; PRO0593,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Homeodomain interacting protein kinase 2; DKFZp686K02111; FLJ23711; HIPK2; PRO0593,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000185,,,,,,,,,,,,,,,,,,,200187,,,,,,,,,HIPK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200126,"[""GNRHR2 gene""]",,"A gonadotropin-releasing hormone II receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P88] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400050,,,,,,,,"A gonadotropin-releasing hormone II receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P88] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200126,,,,,,,,,,,,,,,,,GNRHR2,,,,,,,,,,,GNRHR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400203,"[""PDK1 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400203,,,,,,,,,,,,,,,,,,,,,,,,,,,,PDK1 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200811,"[""TAS1R2 gene""]",,"A taste receptor type 1 member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TE23] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400015,,,,,,,,"A taste receptor type 1 member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TE23] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200811,,,,,,,,,,,,,,,,80834,TAS1R2,GPR71|T1R2|TR2,,,,,,,,,,TAS1R2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117491,"[""Nuclear receptor ror-beta""]",,"A nuclear receptor ROR-beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92753] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117464,,,,,,,,"A nuclear receptor ROR-beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92753] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117491,,,,https://pharos.nih.gov/idg/targets/Q92753,,,,,,,,,,,,,RORB,RZRB,,Q92753,,,,,,,,Nuclear receptor ror-beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200697,"[""OR8H1 gene""]",,"An olfactory receptor 8H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 8H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200697,,,,,,,,,,,,,,,,219469,OR8H1,,,,,,,,,,,OR8H1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200531,"[""OR2J2 gene""]",,"An olfactory receptor 2J2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76002] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2J2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76002] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200531,,,,,,,,,,,,,,,,26707,OR2J2,,,,,,,,,,,OR2J2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8838,"[""Hodgkin's lymphoma, nodular sclerosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_8567,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8838,,,,UMLS_CUI:C0152268|NCI:C3518|SNOMEDCT_US_2016_03_01:188573006|ICD9CM:201.5|SNOMEDCT_US_2016_03_01:134178004|ICD10CM:C81.1|SNOMEDCT_US_2016_03_01:188564003|SNOMEDCT_US_2016_03_01:52248008|SNOMEDCT_US_2016_03_01:118608000,"Classical Hodgkin lymphoma, nodular sclerosis|NSHL|Hodgkin's disease, nodular sclerosis of unspecified site (disorder)|Hodgkin lymphoma, nodular sclerosis|Hodgkin's disease, nodular sclerosis NOS (morphologic abnormality)|Hodgkin's disease, nodular sclerosis (disorder)|Hodgkin's disease nodular sclerosis NOS|Hodgkin's disease, nodular sclerosis NOS (disorder)",,disease_ontology,"Hodgkin's disease, nodular sclerosis",DOID:8838,,,,,,,,,,,,,,,,,,,"Hodgkin's lymphoma, nodular sclerosis",,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200077,"[""CLCN6 gene""]",,"This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown. [provided by RefSeq, Mar 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400400,,,,,,,,"This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown. [provided by RefSeq, Mar 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200077,,,,,,,,,,,,,,,,1185,CLCN6,KIAA0046,,,,,,,,,,CLCN6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001302,"[""sternum""]",,"A compound ventral bone or cartilage of most vertebrates other than fishes that connects the ribs or the shoulder girdle or both and in humans consists of the manubrium, gladiolus, and xiphoid process.",false,,,http://purl.obolibrary.org/obo/UBERON_0001474|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000140,,,,,,,,"A compound ventral bone or cartilage of most vertebrates other than fishes that connects the ribs or the shoulder girdle or both and in humans consists of the manubrium, gladiolus, and xiphoid process.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001302,,,,,,,BrendaTissueOBO,breastbone,BTO:0001302,,,,,,,,,,,,,,,,,,,sternum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100317,"[""Olfactory receptor 10K1""]",,"An olfactory receptor 10K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100317,,,,https://pharos.nih.gov/idg/targets/Q8NGX5,,,,,,,,,,,,,OR10K1,,,Q8NGX5,,,,,,,,Olfactory receptor 10K1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100176,"[""Calcium-activated potassium channel subunit beta-1""]",,"A calcium-activated potassium channel subunit beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16558] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300438,,,,,,,,"A calcium-activated potassium channel subunit beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16558] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100176,,,,https://pharos.nih.gov/idg/targets/Q16558,,,,,,,,,,,,,KCNMB1,,,Q16558,,,,,,,,Calcium-activated potassium channel subunit beta-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3869,"[""childhood medulloblastoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0050902,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3869,,,,UMLS_CUI:C0278510|MESH:D008527|NCI:C3997,pediatric Medulloblastoma,,disease_ontology,,DOID:3869,,,,,,,,,,,,,,,,,,,childhood medulloblastoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000466,"[""YSK1 kinase domain""]",,Serine/threonine-protein kinase 26,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase 26,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000466,,,,,,,,,,,,,,,,,,,200466,,,,,,,,,YSK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000254,"[""female reproductive gland""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001488,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000254,,,,,,,BrendaTissueOBO,,BTO:0000254,,,,,,,,,,,,,,,,,,,female reproductive gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2926,"[""Klippel-Trenaunay syndrome""]",,A syndrome that is characterized by large cutaneous hemangiomata with hypertrophy of the related bones and soft tissues.,false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,A syndrome that is characterized by large cutaneous hemangiomata with hypertrophy of the related bones and soft tissues.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2926,,,,SNOMEDCT_US_2016_03_01:59078009|ICD10CM:Q87.2|UMLS_CUI:C0022739|OMIM:149000|MESH:D007715|NCI:C84801,angioosteohypertrophy syndrome|Klippel-Trenaunay-Weber syndrome|Haemangiectatic hypertrophy,,disease_ontology,,DOID:2926,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Klippel-Trenaunay syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300547,"[""Kv4.3/KCND3 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300444,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300547,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv4.3/KCND3 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200604,"[""OR4P4 gene""]",,"An olfactory receptor 4P4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4P4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200604,,,,,,,,,,,,,,,,81300,OR4P4,OR4P3P,,,,,,,,,,OR4P4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8545,"[""malignant hyperthermia""]",,"A genetic disease that is characterized by a drastic and uncontrolled increase in skeletal muscle oxidative metabolism, which overwhelms the body's capacity to supply oxygen, remove carbon dioxide, and regulate body temperature.",false,,,http://purl.obolibrary.org/obo/DOID_630,,,,,,,,"A genetic disease that is characterized by a drastic and uncontrolled increase in skeletal muscle oxidative metabolism, which overwhelms the body's capacity to supply oxygen, remove carbon dioxide, and regulate body temperature.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8545,,,,UMLS_CUI:C0024591|OMIM:145600|MESH:D008305|SNOMEDCT_US_2016_03_01:157762007|OMIM:600467|SNOMEDCT_US_2016_03_01:213026003|SNOMEDCT_US_2016_03_01:248453001|ICD9CM:995.86|SNOMEDCT_US_2016_03_01:111738008|OMIM:154276|SNOMEDCT_US_2016_03_01:405500008|SNOMEDCT_US_2016_03_01:269435009|ICD10CM:T88.3|OMIM:601888|OMIM:154275|SNOMEDCT_US_2016_03_01:405501007|ORDO:423|NCI:C84869|OMIM:601887,malignant hyperpyrexia due to anesthesia|anesthesia related hyperthermia,,disease_ontology,,DOID:8545,http://purl.obolibrary.org/obo/doid#DO_MGI_slim|http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,malignant hyperthermia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200443,"[""OR56B2P gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200443,,,,,,,,,,,,,,,,390073,OR56B2P,,,,,,,,,,,OR56B2P gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300129,"[""PIKK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300108,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300129,,,,,,,,,,,,,,,,,,,,,,,,,,,,PIKK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100634,"[""Pantothenate kinase 3""]",,"A pantothenate kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H999] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391028,,,,,,,,"A pantothenate kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H999] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100634,,,,https://pharos.nih.gov/idg/targets/Q9H999,,,,,,,,,,,,,PANK3,,,Q9H999,,,,,,,,Pantothenate kinase 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11175,"[""enophthalmos""]",,,false,,,http://purl.obolibrary.org/obo/DOID_930,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11175,,,,UMLS_CUI:C0014306|ICD10CM:H05.4|MESH:D015841|ICD10CM:H05.40|ICD9CM:376.5|SNOMEDCT_US_2016_03_01:155200004|SNOMEDCT_US_2016_03_01:267746003|SNOMEDCT_US_2016_03_01:194031000|NCI:C79552|SNOMEDCT_US_2016_03_01:80093006|ICD9CM:376.50,,,disease_ontology,,DOID:11175,,,,,,,,,,,,,,,,,,,enophthalmos,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100623,"[""L-seryl-tRNA(Sec) kinase""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100623,,,,,,,,,,,,,,,,,PSTK,,,Q8IV42,,,,,,,,L-seryl-tRNA(Sec) kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100111,"[""Myotonin-protein kinase""]",,"myotonin-protein kinase (DMPK)  with  no mutation  in a nonphosphorylated state|A myotonin-protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q09013] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300265,,,,,,,,"myotonin-protein kinase (DMPK)  with  no mutation  in a nonphosphorylated state|A myotonin-protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q09013] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100111,,,,https://pharos.nih.gov/idg/targets/Q09013,,,,,,,,,,,,,DMPK,DM1PK|MDPK,,Q09013,,,,,,,,Myotonin-protein kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100532,"[""Non-receptor tyrosine-protein kinase tnk1""]",,"A non-receptor tyrosine-protein kinase TNK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13470] |non-receptor tyrosine-protein kinase tnk1 (TNK1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300118,,,,,,,,"A non-receptor tyrosine-protein kinase TNK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13470] |non-receptor tyrosine-protein kinase tnk1 (TNK1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100532,,,,https://pharos.nih.gov/idg/targets/Q13470,,,,,,,,,,,,,TNK1,,,Q13470,,,,,,,,Non-receptor tyrosine-protein kinase tnk1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100451,"[""Receptor-interacting serine/threonine-protein kinase 2""]",,"A receptor-interacting serine/threonine-protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43353] |receptor-interacting serine/threonine-protein kinase 2 (RIPK2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300124,,,,,,,,"A receptor-interacting serine/threonine-protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43353] |receptor-interacting serine/threonine-protein kinase 2 (RIPK2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100451,,,,https://pharos.nih.gov/idg/targets/O43353,,,,,,,,,,,,,RIPK2,CARDIAK|RICK|RIP2,,O43353,,,,,,,,Receptor-interacting serine/threonine-protein kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100063,"[""Voltage-dependent calcium channel gamma-like subunit""]",,"A voltage-dependent calcium channel gamma-like subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WXS4] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300391,,,,,,,,"A voltage-dependent calcium channel gamma-like subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WXS4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100063,,,,https://pharos.nih.gov/idg/targets/Q8WXS4,,,,,,,,,,,,,TMEM37,PR,,Q8WXS4,,,,,,,,Voltage-dependent calcium channel gamma-like subunit,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300417,"[""GRIK2 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300417,,,,,,,,,,,,,,,,,,,,,,,,,,,,GRIK2 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002658,"[""collecting duct cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002658,,,,,,,BrendaTissueOBO,,BTO:0002658,,,,,,,,,,,,,,,,,,,collecting duct cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400209,"[""SGK493 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400209,,,,,,,,,,,,,,,,,,,,,,,,,,,,SGK493 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300333,"[""Calcium channel alpha-1 subunit family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300333,,,,,,,,,,,,,,,,,,,,,,,,,,,,Calcium channel alpha-1 subunit family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000737,"[""leukemia cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001035,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000737,,,,,,,BrendaTissueOBO,,BTO:0000737,,,,,,,,,,,,,,,,,,,leukemia cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005784,"[""syncytium""]",,A multinucleate mass of protoplasm produced by the merging of cells.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002322,,,,,,,,A multinucleate mass of protoplasm produced by the merging of cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005784,Marion,2015-09-30T16:54:44Z,,,,,BrendaTissueOBO,symplasm,BTO:0005784,,,,,,,,,,,,,,,,,,,syncytium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000827,"[""mantle muscle""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0002385|http://purl.obolibrary.org/obo/BTO_0000887,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000827,,,,,,,BrendaTissueOBO,,BTO:0000827,,,,,,,,,,,,,,,,,,,mantle muscle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200048,"[""BRSK1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400253,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200048,,,,,,,,,,,,,,,,84446,BRSK1,KIAA1811|SAD1|SADB,,,,,,,,,,BRSK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000125,"[""MET140 in MP2K3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000125,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET140 in MP2K3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200274,"[""PIEZO1 gene""]",,"Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The FAM38A gene encodes PIEZO1, a protein that induces mechanically activated (MA) currents in various cell types (Coste et al., 2010 [PubMed 20813920]).[supplied by OMIM, Nov 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400366,,,,,,,,"Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The FAM38A gene encodes PIEZO1, a protein that induces mechanically activated (MA) currents in various cell types (Coste et al., 2010 [PubMed 20813920]).[supplied by OMIM, Nov 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200274,,,,,,,,,,,,,,,,9780,PIEZO1,FAM38A|KIAA0233,,,,,,,,,,PIEZO1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004520,"[""regulatory T-lymphocyte""]",,Regulatory T cells are a specialized subpopulation of T cells that act to suppress activation of the immune system and thereby maintain immune system homeostasis and tolerance to self-antigens.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000782,,,,,,,,Regulatory T cells are a specialized subpopulation of T cells that act to suppress activation of the immune system and thereby maintain immune system homeostasis and tolerance to self-antigens.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004520,mgr,2010-02-11T10:28:02Z,,,,,BrendaTissueOBO,Treg cell|suppressor T-lymphocyte|T suppressor cell|Ts cell|regulatory T-cell|suppressor T-cell,BTO:0004520,,,,,,,,,,,,,,,,,,,regulatory T-lymphocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200217,"[""KCNK5 gene""]",,"This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400359,,,,,,,,"This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200217,,,,,,,,,,,,,,,,8645,KCNK5,TASK2,,,,,,,,,,KCNK5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002629,"[""T-lymphoblastoid cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002629,,,,,,,BrendaTissueOBO,T-cell lymphoblastoid cell line,BTO:0002629,,,,,,,,,,,,,,,,,,,T-lymphoblastoid cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200075,"[""CDK9 gene""]",,"The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400263,,,,,,,,"The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200075,,,,,,,,,,,,,,,,1025,CDK9,CDC2L4|TAK,,,,,,,,,,CDK9 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400048,"[""Ghrelin receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400048,,,,,,,,,,,,,,,,,,,,,,,,,,,,Ghrelin receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400492,"[""Alpha-3/CHRNA3 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400492,,,,,,,,,,,,,,,,,,,,,,,,,,,,Alpha-3/CHRNA3 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100144,"[""Focal adhesion kinase 1""]",,"A focal adhesion kinase 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q05397] |focal adhesion kinase 1 (FAK1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300155,,,,,,,,"A focal adhesion kinase 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q05397] |focal adhesion kinase 1 (FAK1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100144,,,,https://pharos.nih.gov/idg/targets/Q05397,,,,,,,,,,,,,PTK2,FAK|FAK1,,Q05397,,,,,,,,Focal adhesion kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003172,"[""KM-12 cell""]",,Human colon carcinoma cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0000797|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human colon carcinoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003172,,,,,,,BrendaTissueOBO,KM12 cell,BTO:0003172,,,,,,,,,,,,,,,,,,,KM-12 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050532,"[""epidermal nevus""]",,OMIM mapping confirmed by DO. [SN].,[true],,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050532,,,,,"PIGMENTED MOLES|NEVUS, KERATINOCYTIC, NONEPIDERMOLYTIC",,disease_ontology,,DOID:0050532,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,epidermal nevus,true,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050534,"[""congenital stationary night blindness""]",,A night blindness that is characterized by hemeralopia with a moderate loss of visual acuity and caused by defective photoreceptor-to-bipolar cell signaling with common ERG findings of reduced or absent b-waves and generally normal a-waves.,false,,,http://purl.obolibrary.org/obo/DOID_8499,,,,,,,,A night blindness that is characterized by hemeralopia with a moderate loss of visual acuity and caused by defective photoreceptor-to-bipolar cell signaling with common ERG findings of reduced or absent b-waves and generally normal a-waves.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050534,,,,SNOMEDCT_US_2016_03_01:193688005|ORDO:215|MESH:C537743|SNOMEDCT_US_2016_03_01:193689002|OMIM:PS310500|SNOMEDCT_US_2016_03_01:193687000|ICD10CM:H53.63|UMLS_CUI:C1306122|SNOMEDCT_US_2016_03_01:89208008|ICD9CM:368.61,congenital essential nyctalopia,,disease_ontology,,DOID:0050534,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,congenital stationary night blindness,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050535,"[""exudative vitreoretinopathy""]",,A retinal vascular disease characterized by the prevention of blood vessel formation at the edges of the retina and the hemorrhage of the blood vessels in the retina.,false,,,http://purl.obolibrary.org/obo/DOID_2462,,,,,,,,A retinal vascular disease characterized by the prevention of blood vessel formation at the edges of the retina and the hemorrhage of the blood vessels in the retina.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050535,,,,ORDO:891|UMLS_CUI:C0004608|ICD9CM:362.10|OMIM:613310|OMIM:305390|SNOMEDCT_US_2016_03_01:42873008|SNOMEDCT_US_2016_03_01:31411005|OMIM:133780|OMIM:605750|ICD10CM:H35.00|OMIM:601813|SNOMEDCT_US_2016_03_01:193355009,FEVR|familial exudative vitreoretinopathy,,disease_ontology,,DOID:0050535,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,exudative vitreoretinopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100640,"[""Olfactory receptor 5m10""]",,"An olfactory receptor 5M10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IEU7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5M10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IEU7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100640,,,,https://pharos.nih.gov/idg/targets/Q6IEU7,,,,,,,,,,,,,OR5M10,,,Q6IEU7,,,,,,,,Olfactory receptor 5m10,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000639,"[""intersegmental muscle""]",,The short intersegmental muscle is located between the prothorax and the mesothorax.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0002385|http://purl.obolibrary.org/obo/BTO_0000887,,,,,,,,The short intersegmental muscle is located between the prothorax and the mesothorax.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000639,,,,,,,BrendaTissueOBO,,BTO:0000639,,,,,,,,,,,,,,,,,,,intersegmental muscle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000442,"[""fat body""]",,A fatty tissue especially of nearly mature insect larvae that serves as a food reserve.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001487,,,,,,,,A fatty tissue especially of nearly mature insect larvae that serves as a food reserve.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000442,,,,,,,BrendaTissueOBO,,BTO:0000442,,,,,,,,,,,,,,,,,,,fat body,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200462,"[""RPS6KL1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400179,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200462,,,,,,,,,,,,,,,,83694,RPS6KL1,,,,,,,,,,,RPS6KL1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003034,"[""HELF cell""]",,Human embryonic lung fibroblast cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000161|http://purl.obolibrary.org/obo/BTO_0001958,,,,,,,,Human embryonic lung fibroblast cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003034,,,,,,,BrendaTissueOBO,hELF cell,BTO:0003034,,,,,,,,,,,,,,,,,,,HELF cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400365,"[""Gap junction-forming innexin (innexin) family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400365,,,,,,,,,,,,,,,,,,,,,,,,,,,,Gap junction-forming innexin (innexin) family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200578,"[""OR4D2 gene""]",,"An olfactory receptor 4D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58180] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58180] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200578,,,,,,,,,,,,,,,,124538,OR4D2,,,,,,,,,,,OR4D2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2526,"[""prostate adenocarcinoma""]",,A prostate carcinoma that derives_from epithelial cells of glandular origin.,false,,,http://purl.obolibrary.org/obo/DOID_10286|http://purl.obolibrary.org/obo/DOID_299,,,,,,,,A prostate carcinoma that derives_from epithelial cells of glandular origin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2526,,,,SNOMEDCT_US_2016_03_01:399490008|NCI:C2919|UMLS_CUI:C0007112,,,disease_ontology,,DOID:2526,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,prostate adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000071,"[""GHRH""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000071,,,,,,,,,,,,,,,,,,,,,,,,,,,,GHRH,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001407,"[""neuroendocrine tumor cell""]",,"A cell of any of a diverse group of tumors containing neurosecretory cells that cause endocrine dysfunction, most are carcinoids or carcinomas. They occur most often in the gastrointestinal tract, in bronchial and tracheal mucous membranes, and in teratoid ovarian tumors.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000729,,,,,,,,"A cell of any of a diverse group of tumors containing neurosecretory cells that cause endocrine dysfunction, most are carcinoids or carcinomas. They occur most often in the gastrointestinal tract, in bronchial and tracheal mucous membranes, and in teratoid ovarian tumors.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001407,,,,,,,BrendaTissueOBO,NET cell|neuroendocrine carcinoma cell,BTO:0001407,,,,,,,,,,,,,,,,,,,neuroendocrine tumor cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100173,"[""Kv channel-interacting protein 2""]",,"A Kv channel-interacting protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NS61] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,"A Kv channel-interacting protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NS61] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100173,,,,https://pharos.nih.gov/idg/targets/Q9NS61,,,,,,,,,,,,,KCNIP2,KCHIP2,,Q9NS61,,,,,,,,Kv channel-interacting protein 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000037,"[""renal cell carcinoma cell""]",,Carcinoma cell of the renal parenchyma usually occurring in middle age or later and composed of tubular cells in varying arrangements; symptoms depend on extent of invasion.,false,,,http://purl.obolibrary.org/obo/BTO_0000680|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000604,,,,,,,,Carcinoma cell of the renal parenchyma usually occurring in middle age or later and composed of tubular cells in varying arrangements; symptoms depend on extent of invasion.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000037,,,,,,,BrendaTissueOBO,hypernephroma cell|clear cell renal cell carcinoma cell|adenocarcinoma cell of kidney|CCRCC cell|Grawitz`s tumor cell|hypernephroid carcinoma cell|clear cell carcinoma cell|kidney adenocarcinoma cell|renal adenocarcinoma cell,BTO:0000037,,,,,,,,,,,,,,,,,,,renal cell carcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000074,"[""5-HT-moduline""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_32952,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000074,,,,,,,,,,,,,,,,,,,,,,,,,,,,5-HT-moduline,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200069,"[""CLCC1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400340,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200069,,,,,,,,,,,,,,,,23155,CLCC1,KIAA0761|MCLC,,,,,,,,,,CLCC1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300061,"[""Histamine receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300061,,,,,,,,,,,,,,,,,,,,,,,,,,,,Histamine receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100265,"[""P2x purinoceptor 2""]",,"A P2X purinoceptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UBL9] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300364,,,,,,,,"A P2X purinoceptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UBL9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100265,,,,https://pharos.nih.gov/idg/targets/Q9UBL9,,,,,,,,,,,,,P2RX2,P2X2,,Q9UBL9,,,,,,,,P2x purinoceptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400375,"[""Acetylcholine receptor subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400328,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400375,,,,,,,,,,,,,,,,,,,,,,,,,,,,Acetylcholine receptor subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200090,"[""CNGB3 gene""]",,"This gene encodes the beta subunit of a cyclic nucleotide-gated ion channel. The encoded beta subunit appears to play a role in modulation of channel function in cone photoreceptors. This heterotetrameric channel is necessary for sensory transduction, and mutations in this gene have been associated with achromatopsia 3, progressive cone dystrophy, and juvenile macular degeneration, also known as Stargardt Disease. [provided by RefSeq, Feb 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400407,,,,,,,,"This gene encodes the beta subunit of a cyclic nucleotide-gated ion channel. The encoded beta subunit appears to play a role in modulation of channel function in cone photoreceptors. This heterotetrameric channel is necessary for sensory transduction, and mutations in this gene have been associated with achromatopsia 3, progressive cone dystrophy, and juvenile macular degeneration, also known as Stargardt Disease. [provided by RefSeq, Feb 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200090,,,,,,,,,,,,,,,,54714,CNGB3,,,,,,,,,,,CNGB3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100286,"[""Ryanodine receptor 3""]",,"A ryanodine receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15413] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300462,,,,,,,,"A ryanodine receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15413] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100286,,,,https://pharos.nih.gov/idg/targets/Q15413,,,,,,,,,,,,,RYR3,HBRR,,Q15413,,,,,,,,Ryanodine receptor 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100307,"[""Olfactory receptor 10h1""]",,"An olfactory receptor 10H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y4A9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y4A9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100307,,,,https://pharos.nih.gov/idg/targets/Q9Y4A9,,,,,,,,,,,,,OR10H1,,,Q9Y4A9,,,,,,,,Olfactory receptor 10h1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004560,"[""thymic medulla""]",,"Histologically, the thymus can be divided into a central medulla and a peripheral cortex which is surrounded by an outer capsule. The cortex and medulla play different roles in the development of T cells. Cells in the thymus can be divided into thymic stromal cells and cells of hematopoietic origin.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Histologically, the thymus can be divided into a central medulla and a peripheral cortex which is surrounded by an outer capsule. The cortex and medulla play different roles in the development of T cells. Cells in the thymus can be divided into thymic stromal cells and cells of hematopoietic origin.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004560,mgr,2010-02-16T08:05:49Z,,,,,BrendaTissueOBO,medulla of thymus|thymus medulla,BTO:0004560,,,,,,,,,,,,,,,,,,,thymic medulla,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4934,"[""apocrine sweat gland cancer""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2095,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4934,,,,NCI:C6800|UMLS_CUI:C1334561,malignant Apocrine tumor,,disease_ontology,,DOID:4934,,,,,,,,,,,,,,,,,,,apocrine sweat gland cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100370,"[""N-terminal kinase-like protein""]",,"An N-terminal kinase-like protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96KG9] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300199,,,,,,,,"An N-terminal kinase-like protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96KG9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100370,,,,https://pharos.nih.gov/idg/targets/Q96KG9,,,,,,,,,,,,,SCYL1,CVAK90|GKLP|NTKL|TAPK|TEIF|TRAP,,Q96KG9,,,,,,,,N-terminal kinase-like protein,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200054,"[""CALHM3 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400335,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200054,,,,,,,,,,,,,,,,119395,CALHM3,FAM26A,,,,,,,,,,CALHM3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400594,"[""TRPV5 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400484,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400594,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPV5 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000336,"[""PHKG1 kinase domain""]",,"Phosphorylase kinase, gamma 1 (muscle); PHKG; PHKG1",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Phosphorylase kinase, gamma 1 (muscle); PHKG; PHKG1",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000336,,,,,,,,,,,,,,,,,,,200319,,,,,,,,,PHKG1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200385,"[""OR51A4 gene""]",,"An olfactory receptor 51A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 51A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200385,,,,,,,,,,,,,,,,401666,OR51A4,,,,,,,,,,,OR51A4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000576,"[""5-oxo-15-HETE""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000576,,,,,,,,,,,,,,,,,,,,,,,,,,,,5-oxo-15-HETE,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050129,"[""secretory diarrhea""]",,"Secretory diarrhea is a diarrhea where there is an increase in the active secretion, or there is an inhibition of absorption causing little to no structural damage. The most common cause of this type of diarrhea is a cholera toxin that stimulates the secretion of anions, especially chloride ions.",false,,,http://purl.obolibrary.org/obo/DOID_13250,,,,,,,,"Secretory diarrhea is a diarrhea where there is an increase in the active secretion, or there is an inhibition of absorption causing little to no structural damage. The most common cause of this type of diarrhea is a cholera toxin that stimulates the secretion of anions, especially chloride ions.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050129,,,,,,,disease_ontology,,DOID:0050129,,,,,,,,,,,,,,,,,,,secretory diarrhea,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050127,"[""sinusitis""]",,"A paranasal sinus disease involving inflammation of the paranasal sinuses resulting from bacterial, fungal, viral infection, allergic or autoimmune issues. Symptoms can include fever, weakness, fatigue, cough and congestion. There may also be mucus drainage in the back of the throat, called postnasal drip.",false,,,http://purl.obolibrary.org/obo/DOID_1352,,,,,,,,"A paranasal sinus disease involving inflammation of the paranasal sinuses resulting from bacterial, fungal, viral infection, allergic or autoimmune issues. Symptoms can include fever, weakness, fatigue, cough and congestion. There may also be mucus drainage in the back of the throat, called postnasal drip.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050127,,,DOID:9564|DOID:2052,SNOMEDCT_US_2016_03_01:155501004|UMLS_CUI:C0149512|SNOMEDCT_US_2016_03_01:195649005|SNOMEDCT_US_2016_03_01:15805002|ICD10CM:J01.90|SNOMEDCT_US_2016_03_01:266378004|SNOMEDCT_US_2016_03_01:195653007|SNOMEDCT_US_2016_03_01:155498004|ICD10CM:J01|ICD9CM:461|ICD9CM:461.9|ICD10CM:J01.9,,,disease_ontology,,DOID:0050127,http://purl.obolibrary.org/obo/doid#NCIthesaurus,,,,,,,,,,,,,,,,,,sinusitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100528,"[""Olfactory receptor 2H2""]",,"An olfactory receptor 2H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95918] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95918] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100528,,,,https://pharos.nih.gov/idg/targets/O95918,,,,,,,,,,,,,OR2H2,FAT11|OLFR2|OR2H3,,O95918,,,,,,,,Olfactory receptor 2H2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100209,"[""Potassium voltage-gated channel subfamily h member 5""]",,"A voltage-gated potassium channel KCNH5 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8NCM2] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300557,,,,,,,,"A voltage-gated potassium channel KCNH5 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8NCM2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100209,,,,https://pharos.nih.gov/idg/targets/Q8NCM2,,,,,,,,,,,,,KCNH5,EAG2,,Q8NCM2,,,,,,,,Potassium voltage-gated channel subfamily h member 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391017,"[""Hexokinase family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300325,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391017,,,,,,,,,,,,,,,,,,,,,,,,,,,,Hexokinase family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13709,"[""premature ejaculation""]",,,false,,,http://purl.obolibrary.org/obo/DOID_10132,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13709,,,,ICD10CM:F52.4|SNOMEDCT_US_2016_03_01:123302009|SNOMEDCT_US_2016_03_01:44001008|SNOMEDCT_US_2016_03_01:268762007|SNOMEDCT_US_2016_03_01:154905005|NCI:C94349|SNOMEDCT_US_2016_03_01:192468006|MESH:D061686|UMLS_CUI:C0033038|ICD9CM:302.75,,,disease_ontology,,DOID:13709,,,,,,,,,,,,,,,,,,,premature ejaculation,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12905,"[""sialolithiasis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_10854,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12905,,,,ICD10CM:K11.5|SNOMEDCT_US_2016_03_01:155656006|SNOMEDCT_US_2016_03_01:196507003|SNOMEDCT_US_2016_03_01:109767003|NCI:C34994|ICD9CM:527.5|MESH:D015494|SNOMEDCT_US_2016_03_01:28826002|UMLS_CUI:C0036091,Sialolith|Salivary gland Stone|Stone of salivary gland or duct,,disease_ontology,,DOID:12905,,,,,,,,,,,,,,,,,,,sialolithiasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200500,"[""STK31 gene""]",,"This gene is similar to a mouse gene that encodes a putative protein kinase with a tudor domain, and shows testis-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400218,,,,,,,,"This gene is similar to a mouse gene that encodes a putative protein kinase with a tudor domain, and shows testis-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200500,,,,,,,,,,,,,,,,56164,STK31,SGK396,,,,,,,,,,STK31 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200030,"[""BEST1 gene""]",,"This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Nov 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400331,,,,,,,,"This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Nov 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200030,,,,,,,,,,,,,,,,7439,BEST1,VMD2,,,,,,,,,,BEST1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001491,"[""viscus""]",,"An internal organ of the body; especially: one (as the heart, liver, or intestine) located in the great cavity of the trunk proper.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"An internal organ of the body; especially: one (as the heart, liver, or intestine) located in the great cavity of the trunk proper.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001491,,,,,,,BrendaTissueOBO,Organsystem|visceral tissue|splanchnic tissue,BTO:0001491,,,,,,,,,,,,,,,,,,,viscus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100006,"[""D1235 in MET(Y1235D)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100006,,,,,,,,,,,,,,,,,,,,,,,,,,,,D1235 in MET(Y1235D),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100342,"[""Zinc-activated ligand-gated ion channel""]",,"A zinc-activated ligand-gated ion channel that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q401N2] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300328,,,,,,,,"A zinc-activated ligand-gated ion channel that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q401N2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100342,,,,https://pharos.nih.gov/idg/targets/Q401N2,,,,,,,,,,,,,ZACN,L2|LGICZ|LGICZ1|ZAC,,Q401N2,,,,,,,,Zinc-activated ligand-gated ion channel,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200198,"[""JAK3 gene""]",,"The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400167,,,,,,,,"The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200198,,,,,,,,,,,,,,,,3718,JAK3,,,,,,,,,,,JAK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001426,"[""urethra""]",,The tube through which urine leaves the body. It empties urine from the bladder.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The tube through which urine leaves the body. It empties urine from the bladder.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001426,,,,,,,BrendaTissueOBO,,BTO:0001426,,,,,,,,,,,,,,,,,,,urethra,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400057,"[""Chemokine receptor-like gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400057,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chemokine receptor-like gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200413,"[""OR52B6 gene""]",,"An olfactory receptor 52B6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 52B6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200413,,,,,,,,,,,,,,,,340980,OR52B6,,,,,,,,,,,OR52B6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100309,"[""Transmembrane channel-like protein 1""]",,"A transmembrane channel-like protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TDI8] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300372,,,,,,,,"A transmembrane channel-like protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TDI8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100309,,,,https://pharos.nih.gov/idg/targets/Q8TDI8,,,,,,,,,,,,,TMC1,,,Q8TDI8,,,,,,,,Transmembrane channel-like protein 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000524,"[""glia""]",,The delicate network of branched cells and fibers that supports the tissue of the central nervous system.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The delicate network of branched cells and fibers that supports the tissue of the central nervous system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000524,,,,,,,BrendaTissueOBO,neuroglia,BTO:0000524,,,,,,,,,,,,,,,,,,,glia,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000456,"[""VGFR2 kinase domain""]",,Vascular endothelial growth factor receptor 2; kinase insert domain receptor; CD309; FLK1; FLK-1; KDR; KRD-1; Ly73; VEGFR; VEGFR2; VEGFR-2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Vascular endothelial growth factor receptor 2; kinase insert domain receptor; CD309; FLK1; FLK-1; KDR; KRD-1; Ly73; VEGFR; VEGFR2; VEGFR-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000456,,,,,,,,,,,,,,,,,,,200458,,,,,,,,,VGFR2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300461,"[""RYR2 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300354,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300461,,,,,,,,,,,,,,,,,,,,,,,,,,,,RYR2 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002480,"[""plume""]",,"Organisms as Riftia pachyptila end with a deep red fan-like structure (plume) which extends into the water and which absorbs H2S and O2 for the bacteria, and also absorbs CO2 for use as synthetic raw material. An animal structure having a main shaft bearing many hairs or filamentous parts; especially: a full bushy tail.",false,,,http://purl.obolibrary.org/obo/BTO_0001492|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001262,,,,,,,,"Organisms as Riftia pachyptila end with a deep red fan-like structure (plume) which extends into the water and which absorbs H2S and O2 for the bacteria, and also absorbs CO2 for use as synthetic raw material. An animal structure having a main shaft bearing many hairs or filamentous parts; especially: a full bushy tail.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002480,,,,,,,BrendaTissueOBO,,BTO:0002480,,,,,,,,,,,,,,,,,,,plume,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002991,"[""glandular epithelium""]",,Epithelium composed of secretory cells.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000416,,,,,,,,Epithelium composed of secretory cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002991,,,,,,,BrendaTissueOBO,,BTO:0002991,,,,,,,,,,,,,,,,,,,glandular epithelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000057,"[""BRSK2 kinase domain""]",,BR serine/threonine kinase 2; BRSK2; C11orf7; FLJ41362; PEN11B; SAD1; STK29,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,BR serine/threonine kinase 2; BRSK2; C11orf7; FLJ41362; PEN11B; SAD1; STK29,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000057,,,,,,,,,,,,,,,,,,,200058,,,,,,,,,BRSK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200132,"[""GPR89B gene""]",,"GPR89A is a nearly identical copy of the GPR89B gene (MIM 612806).[supplied by OMIM, Jun 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400350,,,,,,,,"GPR89A is a nearly identical copy of the GPR89B gene (MIM 612806).[supplied by OMIM, Jun 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200132,,,,,,,,,,,,,,,,51463|653519,GPR89B,GPHRB,,,,,,,,,,GPR89B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8398,"[""osteoarthritis""]",,An arthritis that has_material_basis_in worn out cartilage located_in joint.,false,,,http://purl.obolibrary.org/obo/DOID_848,,,,,,,,An arthritis that has_material_basis_in worn out cartilage located_in joint.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8398,,,,OMIM:612401|ICD9CM:715.3|OMIM:140600|OMIM:612400|UMLS_CUI:C0157946|EFO:0002506|OMIM:610839|OMIM:607850|OMIM:165720,degenerative joint disease|osteoarthrosis|degenerative arthritis|hypertrophic arthritis|Osteoarthrosis and allied disorder,,disease_ontology,,DOID:8398,,,,,,,,,,,,,,,,,Xref MGI.,,osteoarthritis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5604,"[""adult acute lymphocytic leukemia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_9952,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5604,,,,NCI:C4967|UMLS_CUI:C0751606,adult acute lymphoid Leukemia,,disease_ontology,,DOID:5604,,,,,,,,,,,,,,,,,,,adult acute lymphocytic leukemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000179,"[""MET481 in PAK6""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000179,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET481 in PAK6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000457,"[""CHO-K1 cell""]",,"Chinese hamster ovary cells, subclone from parental CHO cell line that was initiated from an ovary biopsy of an adult Chinese hamster in 1957.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Chinese hamster ovary cells, subclone from parental CHO cell line that was initiated from an ovary biopsy of an adult Chinese hamster in 1957.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000457,,,,,,,BrendaTissueOBO,,BTO:0000457,,,,,,,,,,,,,,,,,,,CHO-K1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100165,"[""Glycogen synthase kinase-3 beta""]",,"glycogen synthase kinase-3 beta (GSK3B)  with  no mutation  in a nonphosphorylated state|A glycogen synthase kinase-3 beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49841] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300272,,,,,,,,"glycogen synthase kinase-3 beta (GSK3B)  with  no mutation  in a nonphosphorylated state|A glycogen synthase kinase-3 beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49841] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100165,,,,https://pharos.nih.gov/idg/targets/P49841,,,,,,,,,,,,,GSK3B,,,P49841,,,,,,,,Glycogen synthase kinase-3 beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000367,"[""PLK1 kinase domain""]",,Serine/threonine-protein kinase PLK1; polo-like kinase 1 (Drosophila); PLK; PLK1; STPK13,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase PLK1; polo-like kinase 1 (Drosophila); PLK; PLK1; STPK13,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000367,,,,,,,,,,,,,,,,,,,200350,,,,,,,,,PLK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200353,"[""NEK10 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400197,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200353,,,,,,,,,,,,,,,,152110,NEK10,,,,,,,,,,,NEK10 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200052,"[""CALHM1 gene""]",,"This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.[provided by RefSeq, Mar 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400335,,,,,,,,"This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.[provided by RefSeq, Mar 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200052,,,,,,,,,,,,,,,,255022,CALHM1,FAM26C,,,,,,,,,,CALHM1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004364,"[""gastroesophageal junction""]",,The junction between the stomach and the esophagus; the place where the esophagus connects to the stomach.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The junction between the stomach and the esophagus; the place where the esophagus connects to the stomach.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004364,,,,,,,BrendaTissueOBO,,BTO:0004364,,,,,,,,,,,,,,,,,,,gastroesophageal junction,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13413,"[""hepatic encephalopathy""]",,"A brain disease that is characterized by loss of brain function, the occurrence of confusion, altered level of consciousness, and coma that results when the liver is unable to remove toxins from the blood.",false,,,http://purl.obolibrary.org/obo/DOID_936,,,,,,,,"A brain disease that is characterized by loss of brain function, the occurrence of confusion, altered level of consciousness, and coma that results when the liver is unable to remove toxins from the blood.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13413,,,,MESH:D006501|UMLS_CUI:C0019151|ICD9CM:572.2|ICD10CM:K72|SNOMEDCT_US_2016_03_01:449902003|NCI:C79596|SNOMEDCT_US_2016_03_01:197332007|SNOMEDCT_US_2016_03_01:13920009|SNOMEDCT_US_2016_03_01:123049003,Portal-systemic encephalopathy,,disease_ontology,,DOID:13413,,,,,,,,,,,,,,,,,,,hepatic encephalopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200150,"[""KCNJ11 gene""]",,"Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400422,,,,,,,,"Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200150,,,,,,,,,,,,,,,,3767,KCNJ11,,,,,,,,,,,KCNJ11 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100653,"[""Olfactory receptor 6b3""]",,"An olfactory receptor 6B3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGW1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6B3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGW1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100653,,,,https://pharos.nih.gov/idg/targets/Q8NGW1,,,,,,,,,,,,,OR6B3,OR6B3P,,Q8NGW1,,,,,,,,Olfactory receptor 6b3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2001,"[""neuroma""]",,A nervous system benign neoplasm that is characterized as a nerve tissue tumor.,false,,,http://purl.obolibrary.org/obo/DOID_0060115,,,,,,,,A nervous system benign neoplasm that is characterized as a nerve tissue tumor.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2001,,,,UMLS_CUI:C0027858|SNOMEDCT_US_2016_03_01:25169009|SNOMEDCT_US_2016_03_01:274089002|MESH:D009463|NCI:C3275|SNOMEDCT_US_2016_03_01:189950003|SNOMEDCT_US_2016_03_01:443892003|SNOMEDCT_US_2016_03_01:154622009,,,disease_ontology,,DOID:2001,,,,,,,,,,,,,,,,,,,neuroma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000321,"[""NUAK1 kinase domain""]",,"NUAK family, SNF1-like kinase, 1; ARK5; KIAA0537; NUAK1",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"NUAK family, SNF1-like kinase, 1; ARK5; KIAA0537; NUAK1",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000321,,,,,,,,,,,,,,,,,,,200041,,,,,,,,,NUAK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003135,"[""zona pellucida""]",,"A thick, transparent, noncellular layer or envelope of uniform thickness surrounding an oocyte. Under the light microscope it appears as a radially striated layer; under the electron microscope this can be seen to be microvillous.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A thick, transparent, noncellular layer or envelope of uniform thickness surrounding an oocyte. Under the light microscope it appears as a radially striated layer; under the electron microscope this can be seen to be microvillous.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003135,,,,,,,BrendaTissueOBO,striated membrane|zona radiata|zona striata|pellucid zone|oolemma,BTO:0003135,,,,,,,,,,,,,,,,,,,zona pellucida,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200298,"[""SCN7A gene""]",,"This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels; domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown. [provided by RefSeq, Dec 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400472,,,,,,,,"This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels; domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown. [provided by RefSeq, Dec 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200298,,,,,,,,,,,,,,,,6332,SCN7A,SCN6A,,,,,,,,,,SCN7A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400531,"[""KCa1.1/KCNMA1 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400437,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400531,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCa1.1/KCNMA1 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000397,"[""tooth""]",,1: One of the hard bony appendages that are borne on the jaws or in many of the lower vertebrates on other bones in the walls of the mouth or pharynx and serve especially for the prehension and mastication of food and as weapons of offense and defense. 2: Any of various usually hard and sharp processes especially about the mouth of an invertebrate.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,1: One of the hard bony appendages that are borne on the jaws or in many of the lower vertebrates on other bones in the walls of the mouth or pharynx and serve especially for the prehension and mastication of food and as weapons of offense and defense. 2: Any of various usually hard and sharp processes especially about the mouth of an invertebrate.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000397,,,,,,,BrendaTissueOBO,,BTO:0000397,,,,,,,,,,,,,,,,,,,tooth,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13487,"[""childhood disintegrative disease""]",,"A pervasive developmental disorder that is a rare condition characterized by late onset (>3 years of age) of developmental delays in language, social function, and motor skills where children who have had previously normal development who then appear to regress.",false,,,http://purl.obolibrary.org/obo/DOID_0060040,,,,,,,,"A pervasive developmental disorder that is a rare condition characterized by late onset (>3 years of age) of developmental delays in language, social function, and motor skills where children who have had previously normal development who then appear to regress.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13487,,,,NCI:C97164|UMLS_CUI:C0236791|ICD10CM:F84.3|SNOMEDCT_US_2016_03_01:192584009|SNOMEDCT_US_2016_03_01:191694008|SNOMEDCT_US_2016_03_01:71961003|ICD9CM:299.1,Disintegrative psychosis NOS (disorder)|Symbiotic psychosis|Heller's syndrome,,disease_ontology,,DOID:13487,,,,,,,,,,,,,,,,,,,childhood disintegrative disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13482,"[""Proteus syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0080015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13482,,,,MESH:D016715|UMLS_CUI:C0085261|SNOMEDCT_US_2016_03_01:394527003|NCI:C85032|SNOMEDCT_US_2016_03_01:23150001|OMIM:176920,Wiedemann's syndrome,,disease_ontology,,DOID:13482,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Proteus syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13481,"[""thanatophoric dysplasia""]",,An osteochondrodysplasia that results_in short arms and legs with excess folds of skin.,false,,,http://purl.obolibrary.org/obo/DOID_2256,,,,,,,,An osteochondrodysplasia that results_in short arms and legs with excess folds of skin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13481,,,,ORDO:93274|OMIM:273680|ORDO:2655|NCI:C85187|SNOMEDCT_US_2016_03_01:29352008|OMIM:187600|OMIM:187601|MESH:D013796|ORDO:1860|UMLS_CUI:C0039743|ORDO:93275|ICD10CM:Q77.1,,,disease_ontology,,DOID:13481,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [LS].",,thanatophoric dysplasia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200120,"[""EIF2AK3 gene""]",,"The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Jan 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400268,,,,,,,,"The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Jan 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200120,,,,,,,,,,,,,,,,9451,EIF2AK3,PEK|PERK,,,,,,,,,,EIF2AK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000003,"[""Adrenocorticotropic hormone (ACTH)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000003,,,,,,,,,,,,,,,,,,,,,,,,,,,,Adrenocorticotropic hormone (ACTH),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400584,"[""TRPM2 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400483,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400584,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPM2 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200334,"[""TRPV2 gene""]",,"This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400591,,,,,,,,"This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200334,,,,,,,,,,,,,,,,51393,TRPV2,VRL,,,,,,,,,,TRPV2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100461,"[""Olfactory receptor 6C75""]",,"An olfactory receptor 6C75 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NL08] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6C75 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NL08] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100461,,,,https://pharos.nih.gov/idg/targets/A6NL08,,,,,,,,,,,,,OR6C75,,,A6NL08,,,,,,,,Olfactory receptor 6C75,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200254,"[""MC5R gene""]",,"A melanocortin receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P33032] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400021,,,,,,,,"A melanocortin receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P33032] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200254,,,,,,,,,,,,,,,,4161,MC5R,,,,,,,,,,,MC5R gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300503,"[""Delta/CHRND sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300503,,,,,,,,,,,,,,,,,,,,,,,,,,,,Delta/CHRND sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491012,"[""Type I phosphatidylinositol-4-phosphate 5-kinase family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400323,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491012,,,,,,,,,,,,,,,,,,,,,,,,,,,,Type I phosphatidylinositol-4-phosphate 5-kinase family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300220,"[""SEV family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300220,,,,,,,,,,,,,,,,,,,,,,,,,,,,SEV family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100434,"[""Putative olfactory receptor 52p1""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100434,,,,https://pharos.nih.gov/idg/targets/Q8NH57,,,,,,,,,,,,,OR52P1P,OR52P1,,Q8NH57,,,,,,,,Putative olfactory receptor 52p1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100692,"[""Olfactory receptor 8D2""]",,"An olfactory receptor 8D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZM6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 8D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZM6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100692,,,,https://pharos.nih.gov/idg/targets/Q9GZM6,,,,,,,,,,,,,OR8D2,,,Q9GZM6,,,,,,,,Olfactory receptor 8D2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4977,"[""lymphedema""]",,,false,,,http://purl.obolibrary.org/obo/DOID_75,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4977,,,,UMLS_CUI:C0024236|SNOMEDCT_US_2016_03_01:195486001|SNOMEDCT_US_2016_03_01:266334008|MESH:D008209|SNOMEDCT_US_2016_03_01:30213001|SNOMEDCT_US_2016_03_01:234097001|SNOMEDCT_US_2016_03_01:155485008|NCI:C3207,Lymphatic edema (morphologic abnormality)|Lymphoedema NOS,,disease_ontology,,DOID:4977,,,,,,,,,,,,,,,,,,,lymphedema,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300573,"[""Kv8.2/KCNV2 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300451,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300573,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv8.2/KCNV2 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100488,"[""Srsf protein kinase 3""]",,"SRSF protein kinase 3 (SRPK3)  with  no mutation  in a nonphosphorylated state|An SRSF protein kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UPE1] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300226,,,,,,,,"SRSF protein kinase 3 (SRPK3)  with  no mutation  in a nonphosphorylated state|An SRSF protein kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UPE1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100488,,,,https://pharos.nih.gov/idg/targets/Q9UPE1,,,,,,,,,,,,,SRPK3,MSSK1|STK23,,Q9UPE1,,,,,,,,Srsf protein kinase 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000902,"[""plant vessel""]",,One of the tubular conductive vessels in the xylem of vascular plants.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,One of the tubular conductive vessels in the xylem of vascular plants.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000902,Marion,2013-11-07T09:22:23Z,,,,,BrendaTissueOBO,tracheid|plant tracheid|plant trachea|trachea,BTO:0000902,,,,,,,,,,,,,,,,,,,plant vessel,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100270,"[""Serine/threonine-protein kinase lmtk2""]",,"A serine/threonine-protein kinase LMTK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IWU2] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300183,,,,,,,,"A serine/threonine-protein kinase LMTK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IWU2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100270,,,,https://pharos.nih.gov/idg/targets/Q8IWU2,,,,,,,,,,,,,LMTK2,AATYK2|BREK|KIAA1079|KPI2|LMR2,,Q8IWU2,,,,,,,,Serine/threonine-protein kinase lmtk2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200263,"[""DTYMK gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200263,,,,,,,,,,,,,,,,1841,DTYMK,CDC8|TMPK|TYMK,,,,,,,,,,DTYMK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001424,"[""uterus""]",,An organ of the female mammal for containing and usually for nourishing the young during development previous to birth.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003099|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,,An organ of the female mammal for containing and usually for nourishing the young during development previous to birth.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001424,,,,,,,BrendaTissueOBO,womb,BTO:0001424,,,,,,,,,,,,,,,,,,,uterus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200084,"[""CHKA gene""]",,"The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03491029,,,,,,,,"The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200084,,,,,,,,,,,,,,,,1119,CHKA,CHK|CKI,,,,,,,,,,CHKA gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000386,"[""THR699 in EPHB2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000386,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR699 in EPHB2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001906,"[""cephalothorax""]",,The united head and thorax of an arachnid or higher crustacean.,false,,,http://purl.obolibrary.org/obo/BTO_0001368|http://purl.obolibrary.org/obo/UBERON_0007811|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000282,,,,,,,,The united head and thorax of an arachnid or higher crustacean.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001906,,,,,,,BrendaTissueOBO,,BTO:0001906,,,,,,,,,,,,,,,,,,,cephalothorax,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004782,"[""SK-N-BE(2)C cell""]",,Human neuroblastoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human neuroblastoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004782,mgr,2010-10-04T09:13:35Z,,,,,BrendaTissueOBO,SK-N-BE(2)-C cell|BE(2)C cell,BTO:0004782,,,,,,,,,,,,,,,,,,,SK-N-BE(2)C cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100079,"[""C-x-c chemokine receptor type 5""]",,"A C-X-C chemokine receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32302] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300097,,,,,,,,"A C-X-C chemokine receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32302] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100079,,,,https://pharos.nih.gov/idg/targets/P32302,,,,,,,,,,,,,CXCR5,BLR1|MDR15,,P32302,,,,,,,,C-x-c chemokine receptor type 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000751,"[""leukocyte""]",,"Any of the blood cells that are colorless, lack hemoglobin, contain a nucleus, and include the lymphocytes, monocytes, neutrophils, eosinophils, and basophils.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000574,,,,,,,,"Any of the blood cells that are colorless, lack hemoglobin, contain a nucleus, and include the lymphocytes, monocytes, neutrophils, eosinophils, and basophils.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000751,,,,,,,BrendaTissueOBO,immune cell|PMNC|leucocyte|polymorphonuclear cell|PMN cell|white blood cell,BTO:0000751,,,,,,,,,,,,,,,,,,,leukocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117502,"[""Retinoic acid receptor rxr-beta""]",,"A retinoic acid receptor RXR-beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P28702] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117468,,,,,,,,"A retinoic acid receptor RXR-beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P28702] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117502,,,,https://pharos.nih.gov/idg/targets/P28702,,,,,,,,,,,,,RXRB,,,P28702,,,,,,,,Retinoic acid receptor rxr-beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100595,"[""Olfactory receptor 4k14""]",,"An olfactory receptor 4K14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4K14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100595,,,,https://pharos.nih.gov/idg/targets/Q8NGD5,,,,,,,,,,,,,OR4K14,,,Q8NGD5,,,,,,,,Olfactory receptor 4k14,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200032,"[""ADRBK2 gene""]",,"The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400250,,,,,,,,"The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200032,,,,,,,,,,,,,,,,157,ADRBK2,BARK2|GRK3,,,,,,,,,,ADRBK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1681,"[""heart septal defect""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1682,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1681,,,,NCI:C84482|UMLS_CUI:C0018816|ICD10CM:Q21.9|ICD10CM:Q21|SNOMEDCT_US_2016_03_01:59494005|SNOMEDCT_US_2016_03_01:204290008|SNOMEDCT_US_2016_03_01:253273004|SNOMEDCT_US_2016_03_01:8352002|SNOMEDCT_US_2016_03_01:156916001|SNOMEDCT_US_2016_03_01:287081002|SNOMEDCT_US_2016_03_01:396351009|MESH:D006343,Septal defect NOS|Cardiac septal defects (disorder)|Congenital septal defect of heart (disorder)|Septal defect NOS (disorder)|Cardiac septal defects|septal defect,,disease_ontology,,DOID:1681,,,,,,,,,,,,,,,,,,,heart septal defect,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9296,"[""cleft lip""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0050567,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9296,,,DOID:9333,SNOMEDCT_US_2016_03_01:204606000|SNOMEDCT_US_2016_03_01:62696001|SNOMEDCT_US_2016_03_01:156941008|SNOMEDCT_US_2016_03_01:204609007|ICD10CM:Q36.9|MESH:D002971|UMLS_CUI:C0158651|EFO:0003959|ICD9CM:749.11|NCI:C87175|ICD9CM:749.10|ICD10CM:Q36|SNOMEDCT_US_2016_03_01:80281008|ICD9CM:749.1|UMLS_CUI:C0008924,"cheiloschisis|Labium leporinum|complete unilateral cleft lip|cleft lip, unilateral, complete|hare lip",,disease_ontology,,DOID:9296,,,,,,,,,,,,,,,,,,,cleft lip,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200407,"[""OR51V1 gene""]",,"An olfactory receptor 51V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H2C8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 51V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H2C8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200407,,,,,,,,,,,,,,,,283111,OR51V1,OR51A12,,,,,,,,,,OR51V1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000106,"[""MET111 in MST3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000106,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET111 in MST3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400200,"[""TRK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400200,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003099,"[""internal female genital organ""]",,"The various organs in the female that are concerned with reproduction, including the ovaries, uterine tubes, uterus, and vagina.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The various organs in the female that are concerned with reproduction, including the ovaries, uterine tubes, uterus, and vagina.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003099,,,,,,,BrendaTissueOBO,organa genitalia feminina interna,BTO:0003099,,,,,,,,,,,,,,,,,,,internal female genital organ,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200701,"[""OR8J1 gene""]",,"An olfactory receptor 8J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 8J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200701,,,,,,,,,,,,,,,,219477,OR8J1,,,,,,,,,,,OR8J1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400456,"[""NR2B/GRIN2B subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400456,,,,,,,,,,,,,,,,,,,,,,,,,,,,NR2B/GRIN2B subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100484,"[""Proto-oncogene tyrosine-protein kinase src""]",,"A proto-oncogene tyrosine-protein kinase Src that is encoded in the genome of human. [PRO:CNA, UniProtKB:P12931] |proto-oncogene tyrosine-protein kinase src (SRC)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300132,,,,,,,,"A proto-oncogene tyrosine-protein kinase Src that is encoded in the genome of human. [PRO:CNA, UniProtKB:P12931] |proto-oncogene tyrosine-protein kinase src (SRC)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100484,,,,https://pharos.nih.gov/idg/targets/P12931,,,,,,,,,,,,,SRC,SRC1,,P12931,,,,,,,,Proto-oncogene tyrosine-protein kinase src,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400138,"[""CDKL family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400111,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400138,,,,,,,,,,,,,,,,,,,,,,,,,,,,CDKL family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000081,"[""LEU84 in CHEK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000081,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU84 in CHEK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005598,"[""peritubular contractile cell""]",,Any of various flattened cells that surround seminiferous tubules.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Any of various flattened cells that surround seminiferous tubules.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005598,Marion,2014-03-07T10:08:57Z,,,,,BrendaTissueOBO,myoid cell,BTO:0005598,,,,,,,,,,,,,,,,,,,peritubular contractile cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000756,"[""pituitary gland tumor cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000427,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000756,,,,,,,BrendaTissueOBO,,BTO:0000756,,,,,,,,,,,,,,,,,,,pituitary gland tumor cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300162,"[""RCK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300111,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300162,,,,,,,,,,,,,,,,,,,,,,,,,,,,RCK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100334,"[""Dual specificity mitogen-activated protein kinase kinase 1""]",,"dual specificity mitogen-activated protein kinase kinase 1 (MP2K1)  with  no mutation  in a nonphosphorylated state|A dual specificity mitogen-activated protein kinase kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02750] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300194,,,,,,,,"dual specificity mitogen-activated protein kinase kinase 1 (MP2K1)  with  no mutation  in a nonphosphorylated state|A dual specificity mitogen-activated protein kinase kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02750] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100334,,,,https://pharos.nih.gov/idg/targets/Q02750,,,,,,,,,,,,,MAP2K1,MEK1|PRKMK1,,Q02750,,,,,,,,Dual specificity mitogen-activated protein kinase kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001824,"[""synovial sarcoma cell""]",,A cell of a malignant neoplasm arising in the synovial membrane of the joints and also in synovial cells of tendons and bursae.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001207,,,,,,,,A cell of a malignant neoplasm arising in the synovial membrane of the joints and also in synovial cells of tendons and bursae.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001824,,,,,,,BrendaTissueOBO,synoviosarcoma cell|malignant synovioma cell,BTO:0001824,,,,,,,,,,,,,,,,,,,synovial sarcoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02402003,"[""5-HT4 receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400017,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02402003,,,,,,,,,,,,,,,,,,,,,,,,,,,,5-HT4 receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400120,"[""ABC1 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400108,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400120,,,,,,,,,,,,,,,,,,,,,,,,,,,,ABC1 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001823,"[""synovium""]",,"The dense connective-tissue membrane that secretes synovial fluid and that lines the ligamentous surfaces of articular capsules, tendon sheaths where free movement is necessary, and bursae.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The dense connective-tissue membrane that secretes synovial fluid and that lines the ligamentous surfaces of articular capsules, tendon sheaths where free movement is necessary, and bursae.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001823,,,,,,,BrendaTissueOBO,synovial membrane,BTO:0001823,,,,,,,,,,,,,,,,,,,synovium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100751,"[""Prolactin-releasing peptide receptor""]",,"A prolactin-releasing peptide receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49683] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A prolactin-releasing peptide receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49683] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100751,,,,https://pharos.nih.gov/idg/targets/P49683,,,,,,,,,,,,,PRLHR,GPR10|GR3,,P49683,,,,,,,,Prolactin-releasing peptide receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00500647,"[""Voltage-gated""]",,"""Voltage-gated"" is used in context to certain ion channel proteins. Ion channels that open or close in response to changes in the membrane potential are termed voltage-gated.",false,,,http://www.drugtargetontology.org/dto/DTO_00500669,,,,,,,,"""Voltage-gated"" is used in context to certain ion channel proteins. Ion channels that open or close in response to changes in the membrane potential are termed voltage-gated.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00500647,,,,,,,,,,,,,,,,,,,,,,,,,,,https://courses.washington.edu/conj/membrane/transport.htm,Voltage-gated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80312,"[""Neurokinin B""]","Tachykinin-3|NHXYSAFTNPANFK-HDMCBQFHSA-N|CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(N)=O|1209.531|InChI=1S/C55H79N13O14S2/c1-30(2)21-38(50(77)62-36(47(57)74)17-19-83-5)61-43(69)28-59-55(82)46(31(3)4)68-54(81)40(23-33-15-11-8-12-16-33)65-51(78)39(22-32-13-9-7-10-14-32)64-53(80)42(26-45(72)73)67-52(79)41(24-34-27-58-29-60-34)66-49(76)37(18-20-84-6)63-48(75)35(56)25-44(70)71/h7-16,27,29-31,35-42,46H,17-26,28,56H2,1-6H3,(H2,57,74)(H,58,60)(H,59,82)(H,61,69)(H,62,77)(H,63,75)(H,64,80)(H,65,78)(H,66,76)(H,67,79)(H,68,81)(H,70,71)(H,72,73)/t35-,36-,37-,38-,39-,40-,41-,42-,46-/m0/s1|C55H79N13O14S2|Neuromedin K|0|1210.42400",,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16098,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,"Tachykinin-3|NHXYSAFTNPANFK-HDMCBQFHSA-N|CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(N)=O|1209.531|InChI=1S/C55H79N13O14S2/c1-30(2)21-38(50(77)62-36(47(57)74)17-19-83-5)61-43(69)28-59-55(82)46(31(3)4)68-54(81)40(23-33-15-11-8-12-16-33)65-51(78)39(22-32-13-9-7-10-14-32)64-53(80)42(26-45(72)73)67-52(79)41(24-34-27-58-29-60-34)66-49(76)37(18-20-84-6)63-48(75)35(56)25-44(70)71/h7-16,27,29-31,35-42,46H,17-26,28,56H2,1-6H3,(H2,57,74)(H,58,60)(H,59,82)(H,61,69)(H,62,77)(H,63,75)(H,64,80)(H,65,78)(H,66,76)(H,67,79)(H,68,81)(H,70,71)(H,72,73)/t35-,36-,37-,38-,39-,40-,41-,42-,46-/m0/s1|C55H79N13O14S2|Neuromedin K|0|1210.42400",,,CHEBI:80312,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80312,,,,,Neurokinin B,,CHEBI:80312,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100038,"[""Voltage-dependent p/q-type calcium channel subunit alpha-1a""]",,"A voltage-dependent P/Q-type calcium channel subunit alpha-1A that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00555] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300381,,,,,,,,"A voltage-dependent P/Q-type calcium channel subunit alpha-1A that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00555] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100038,,,,https://pharos.nih.gov/idg/targets/O00555,,,,,,,,,,,,,CACNA1A,CACH4|CACN3|CACNL1A4,,O00555,,,,,,,,Voltage-dependent p/q-type calcium channel subunit alpha-1a,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001470,"[""epidermal cell""]",,Cell of epidermis in animals.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Cell of epidermis in animals.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001470,,,,,,,BrendaTissueOBO,,BTO:0001470,,,,,,,,,,,,,,,,,,,epidermal cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200030,"[""ADRA2A gene""]",,"An alpha-2A adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08913] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400093,,,,,,,,"An alpha-2A adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08913] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200030,,,,,,,,,,,,,,,,150,ADRA2A,ADRA2R|ADRAR,,,,,,,,,,ADRA2A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100094,"[""Free fatty acid receptor 1""]",,"A free fatty acid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14842] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300040,,,,,,,,"A free fatty acid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14842] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100094,,,,https://pharos.nih.gov/idg/targets/O14842,,,,,,,,,,,,,FFAR1,GPR40,,O14842,,,,,,,,Free fatty acid receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100618,"[""ATP-dependent 6-phosphofructokinase, muscle type""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100618,,,,,,,,,,,,,,,,,PFKM,,,P08237,,,,,,,,"ATP-dependent 6-phosphofructokinase, muscle type",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100247,"[""Lutropin-choriogonadotropic hormone receptor""]",,"A lutropin-choriogonadotropic hormone receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P22888] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300042,,,,,,,,"A lutropin-choriogonadotropic hormone receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P22888] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100247,,,,https://pharos.nih.gov/idg/targets/P22888,,,,,,,,,,,,,LHCGR,LCGR|LGR2|LHRHR,,P22888,,,,,,,,Lutropin-choriogonadotropic hormone receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400563,"[""Kv7.3/KCNQ3 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400449,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400563,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv7.3/KCNQ3 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8850,"[""salivary gland cancer""]",,An oral cavity cancer that is located_in the salivary gland.,false,,,http://purl.obolibrary.org/obo/DOID_10854|http://purl.obolibrary.org/obo/DOID_8618,,,,,,,,An oral cavity cancer that is located_in the salivary gland.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8850,,,DOID:9148|DOID:8873,ICD9CM:142.8|ICD10CM:C08|UMLS_CUI:C0153362|SNOMEDCT_US_2016_03_01:187648003,malignant tumor of the Major Salivary gland|malignant neoplasm of salivary gland duct|malignant neoplasm of major salivary gland|malignant neoplasm of salivary gland|malignant tumor of the Salivary gland,,disease_ontology,,DOID:8850,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,salivary gland cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200238,"[""LPAR1 gene""]",,"A lysophosphatidic acid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q92633] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402007,,,,,,,,"A lysophosphatidic acid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q92633] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200238,,,,,,,,,,,,,,,,1902,LPAR1,EDG2|LPA1,,,,,,,,,,LPAR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200558,"[""OR2W6P gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200558,,,,,,,,,,,,,,,,81406,OR2W6P,OR2W7P,,,,,,,,,,OR2W6P gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_65312,"[""corticotropin-releasing hormone (human)""]","CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CO)[C@@H](C)CC)C(C)C)C(C)C)[C@@H](C)CC)C(N)=O|4752.521|Corticoliberin|human/rat CRF|C209H346N60O62S2|Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2|SEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEII-NH2|4755.47800|Corticotropin releasing hormone|InChI=1S/C209H346N60O62S2/c1-31-108(22)163(166(216)291)265-204(329)165(110(24)33-3)266-185(310)130(59-68-158(285)286)244-183(308)132(71-79-333-30)247-188(313)135(81-100(6)7)251-177(302)119(46-37-38-72-210)238-175(300)121(48-40-74-226-208(219)220)240-195(320)144(90-153(215)276)257-198(323)146(95-271)261-194(319)142(88-116-92-223-97-228-116)249-170(295)114(28)231-173(298)123(52-61-150(212)273)241-178(303)124(53-62-151(213)274)235-169(294)113(27)233-186(311)134(80-99(4)5)250-182(307)125(54-63-152(214)275)242-179(304)126(55-64-154(277)278)236-168(293)112(26)230-172(297)120(47-39-73-225-207(217)218)234-167(292)111(25)232-174(299)131(70-78-332-29)246-180(305)128(57-66-156(281)282)245-189(314)139(85-104(14)15)259-201(326)161(106(18)19)263-184(309)129(58-67-157(283)284)243-176(301)122(49-41-75-227-209(221)222)239-187(312)136(82-101(8)9)252-190(315)137(83-102(10)11)253-193(318)143(89-117-93-224-98-229-117)256-192(317)141(87-115-44-35-34-36-45-115)260-202(327)162(107(20)21)264-197(322)140(86-105(16)17)254-196(321)145(91-160(289)290)258-191(316)138(84-103(12)13)255-199(324)147(96-272)262-203(328)164(109(23)32-2)267-200(325)148-50-42-76-268(148)206(331)149-51-43-77-269(149)205(330)133(60-69-159(287)288)248-181(306)127(56-65-155(279)280)237-171(296)118(211)94-270/h34-36,44-45,92-93,97-114,118-149,161-165,270-272H,31-33,37-43,46-91,94-96,210-211H2,1-30H3,(H2,212,273)(H2,213,274)(H2,214,275)(H2,215,276)(H2,216,291)(H,223,228)(H,224,229)(H,230,297)(H,231,298)(H,232,299)(H,233,311)(H,234,292)(H,235,294)(H,236,293)(H,237,296)(H,238,300)(H,239,312)(H,240,320)(H,241,303)(H,242,304)(H,243,301)(H,244,308)(H,245,314)(H,246,305)(H,247,313)(H,248,306)(H,249,295)(H,250,307)(H,251,302)(H,252,315)(H,253,318)(H,254,321)(H,255,324)(H,256,317)(H,257,323)(H,258,316)(H,259,326)(H,260,327)(H,261,319)(H,262,328)(H,263,309)(H,264,322)(H,265,329)(H,266,310)(H,267,325)(H,277,278)(H,279,280)(H,281,282)(H,283,284)(H,285,286)(H,287,288)(H,289,290)(H4,217,218,225)(H4,219,220,226)(H4,221,222,227)/t108-,109-,110-,111-,112-,113-,114-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,161-,162-,163-,164-,165-/m0/s1|KLVRDXBAMSPYKH-RKYZNNDCSA-N|corticotropin-releasing factor (human/rat)|corticotropin-releasing factor (human)|0|CRH","A corticotropin-releasing hormone from human/rat composed of Ser, Glu, Glu, Pro, Pro, Ile, Ser, Leu, Asp, Leu, Val, Phe, His, Leu, Leu, Arg, Glu, Val, Leu, Glu, Met, Ala, Arg, Ala, Glu, Gln, Leu, Ala, Gln, Gln, Ala, His, Ser, Asn, Arg, Lys, Leu, Met, Glu, Ile and Ile-NH2 residues joined in sequence.",false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,PMID:21959975|PMID:22734038|PMID:22137972|PMID:22386641|PMID:22735860|PMID:22698524|PMID:21883143|PMID:22533365|PMID:22000570|PMID:22703673|Reaxys:10331364|KEGG:C16079|Wikipedia:Corticotropin-releasing_hormone|PMID:22494987|PMID:22198557|PMID:22763913,"A corticotropin-releasing hormone from human/rat composed of Ser, Glu, Glu, Pro, Pro, Ile, Ser, Leu, Asp, Leu, Val, Phe, His, Leu, Leu, Arg, Glu, Val, Leu, Glu, Met, Ala, Arg, Ala, Glu, Gln, Leu, Ala, Gln, Gln, Ala, His, Ser, Asn, Arg, Lys, Leu, Met, Glu, Ile and Ile-NH2 residues joined in sequence.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,L-seryl-L-alpha-glutamyl-L-alpha-glutamyl-L-prolyl-L-prolyl-L-isoleucyl-L-seryl-L-leucyl-L-alpha-aspartyl-L-leucyl-L-valyl-L-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-alpha-glutamyl-L-valyl-L-leucyl-L-alpha-glutamyl-L-methionyl-L-alanyl-L-arginyl-L-alanyl-L-alpha-glutamyl-L-glutaminyl-L-leucyl-L-alanyl-L-glutaminyl-L-glutaminyl-L-alanyl-L-histidyl-L-seryl-L-asparaginyl-L-arginyl-L-lysyl-L-leucyl-L-methionyl-L-alpha-glutamyl-L-isoleucyl-L-isoleucinamide,,chebi_ontology,"CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CO)[C@@H](C)CC)C(C)C)C(C)C)[C@@H](C)CC)C(N)=O|4752.521|Corticoliberin|human/rat CRF|C209H346N60O62S2|Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2|SEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEII-NH2|4755.47800|Corticotropin releasing hormone|InChI=1S/C209H346N60O62S2/c1-31-108(22)163(166(216)291)265-204(329)165(110(24)33-3)266-185(310)130(59-68-158(285)286)244-183(308)132(71-79-333-30)247-188(313)135(81-100(6)7)251-177(302)119(46-37-38-72-210)238-175(300)121(48-40-74-226-208(219)220)240-195(320)144(90-153(215)276)257-198(323)146(95-271)261-194(319)142(88-116-92-223-97-228-116)249-170(295)114(28)231-173(298)123(52-61-150(212)273)241-178(303)124(53-62-151(213)274)235-169(294)113(27)233-186(311)134(80-99(4)5)250-182(307)125(54-63-152(214)275)242-179(304)126(55-64-154(277)278)236-168(293)112(26)230-172(297)120(47-39-73-225-207(217)218)234-167(292)111(25)232-174(299)131(70-78-332-29)246-180(305)128(57-66-156(281)282)245-189(314)139(85-104(14)15)259-201(326)161(106(18)19)263-184(309)129(58-67-157(283)284)243-176(301)122(49-41-75-227-209(221)222)239-187(312)136(82-101(8)9)252-190(315)137(83-102(10)11)253-193(318)143(89-117-93-224-98-229-117)256-192(317)141(87-115-44-35-34-36-45-115)260-202(327)162(107(20)21)264-197(322)140(86-105(16)17)254-196(321)145(91-160(289)290)258-191(316)138(84-103(12)13)255-199(324)147(96-272)262-203(328)164(109(23)32-2)267-200(325)148-50-42-76-268(148)206(331)149-51-43-77-269(149)205(330)133(60-69-159(287)288)248-181(306)127(56-65-155(279)280)237-171(296)118(211)94-270/h34-36,44-45,92-93,97-114,118-149,161-165,270-272H,31-33,37-43,46-91,94-96,210-211H2,1-30H3,(H2,212,273)(H2,213,274)(H2,214,275)(H2,215,276)(H2,216,291)(H,223,228)(H,224,229)(H,230,297)(H,231,298)(H,232,299)(H,233,311)(H,234,292)(H,235,294)(H,236,293)(H,237,296)(H,238,300)(H,239,312)(H,240,320)(H,241,303)(H,242,304)(H,243,301)(H,244,308)(H,245,314)(H,246,305)(H,247,313)(H,248,306)(H,249,295)(H,250,307)(H,251,302)(H,252,315)(H,253,318)(H,254,321)(H,255,324)(H,256,317)(H,257,323)(H,258,316)(H,259,326)(H,260,327)(H,261,319)(H,262,328)(H,263,309)(H,264,322)(H,265,329)(H,266,310)(H,267,325)(H,277,278)(H,279,280)(H,281,282)(H,283,284)(H,285,286)(H,287,288)(H,289,290)(H4,217,218,225)(H4,219,220,226)(H4,221,222,227)/t108-,109-,110-,111-,112-,113-,114-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,161-,162-,163-,164-,165-/m0/s1|KLVRDXBAMSPYKH-RKYZNNDCSA-N|corticotropin-releasing factor (human/rat)|corticotropin-releasing factor (human)|0|CRH",,,CHEBI:65312,,,,,,,,,,,,,,,,,,,,,,,CHEBI:65312,,,,,corticotropin-releasing hormone (human),,CHEBI:65312,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050963,"[""spinocerebellar ataxia type 13""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1441,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050963,lschriml,2015-10-05T16:12:39Z,,OMIM:605259,,,disease_ontology,,DOID:0050963,,,,,,,,,,,,,,,,,,,spinocerebellar ataxia type 13,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050961,"[""spinocerebellar ataxia type 11""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1441,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050961,lschriml,2015-10-05T16:12:39Z,,OMIM:604432,,,disease_ontology,,DOID:0050961,,,,,,,,,,,,,,,,,,,spinocerebellar ataxia type 11,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050964,"[""spinocerebellar ataxia type 14""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1441,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050964,lschriml,2015-10-05T16:12:39Z,,OMIM:605361,,,disease_ontology,,DOID:0050964,,,,,,,,,,,,,,,,,,,spinocerebellar ataxia type 14,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2560,"[""morphine dependence""]",,An opiate dependence that involves the continued use of morphine despite despite problems related to use of the substance.,false,,,http://purl.obolibrary.org/obo/DOID_2559,,,,,,,,An opiate dependence that involves the continued use of morphine despite despite problems related to use of the substance.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2560,,,,UMLS_CUI:C0026552|SNOMEDCT_US_2016_03_01:191817000|SNOMEDCT_US_2016_03_01:286934009|MESH:D009021|SNOMEDCT_US_2016_03_01:231479000,,,disease_ontology,,DOID:2560,,,,,,,,,,,,,,,,,,,morphine dependence,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200016,"[""ADORA3 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200016,,,,,,,,,,,,,,,,140,ADORA3,,,,,,,,,,,ADORA3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100391,"[""Olfactory receptor 51D1""]",,"An olfactory receptor 51D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 51D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100391,,,,https://pharos.nih.gov/idg/targets/Q8NGF3,,,,,,,,,,,,,OR51D1,,,Q8NGF3,,,,,,,,Olfactory receptor 51D1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000183,"[""MET499 in FAK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000183,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET499 in FAK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300477,"[""SCNN1A subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300330,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300477,,,,,,,,,,,,,,,,,,,,,,,,,,,,SCNN1A subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000161,"[""FGFR3(G697C) kinase domain""]",,Fibroblast growth factor receptor 3; ACH; CD333; CEK2; FGFR3; HSFGFR3EX; JTK4,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Fibroblast growth factor receptor 3; ACH; CD333; CEK2; FGFR3; HSFGFR3EX; JTK4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000161,,,,,,,,,,,,,,,,,,,200164,,,,,,,,,FGFR3(G697C) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000243,"[""PHE124 in MKNK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000243,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE124 in MKNK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003963,"[""nucleus solitarius""]",,"Gray matter located in the dorsomedial part of the medulla oblongata associated with the solitary tract. The solitary nucleus receives inputs from most organ systems including the terminations of the facial, glossopharyngeal, and vagus nerves. It is a major coordinator of autonomic nervous system regulation of cardiovascular, respiratory, gustatory, gastrointestinal, and chemoreceptive aspects of homeostasis. The solitary nucleus is also notable for the large number of neurotransmitters which are found therein.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Gray matter located in the dorsomedial part of the medulla oblongata associated with the solitary tract. The solitary nucleus receives inputs from most organ systems including the terminations of the facial, glossopharyngeal, and vagus nerves. It is a major coordinator of autonomic nervous system regulation of cardiovascular, respiratory, gustatory, gastrointestinal, and chemoreceptive aspects of homeostasis. The solitary nucleus is also notable for the large number of neurotransmitters which are found therein.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003963,,,,,,,BrendaTissueOBO,nucleus tractus solitarii|Geschmackskern|solitary nucleus,BTO:0003963,,,,,,,,,,,,,,,,,,,nucleus solitarius,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004139,"[""LAD-2 cell""]",,Growth factor-dependent human mast cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001668,,,,,,,,Growth factor-dependent human mast cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004139,,,,,,,BrendaTissueOBO,LAD2 cell|LAD 2 cell,BTO:0004139,,,,,,,,,,,,,,,,,,,LAD-2 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000166,"[""FLT3(D835Y) kinase domain""]",,Fms-related tyrosine kinase 3; CD135; FLK2; FLK-2; FLT3; FLT-3; Ly72; STK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Fms-related tyrosine kinase 3; CD135; FLK2; FLK-2; FLT3; FLT-3; Ly72; STK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000166,,,,,,,,,,,,,,,,,,,200170,,,,,,,,,FLT3(D835Y) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100318,"[""Mitogen-activated protein kinase 6""]",,"mitogen-activated protein kinase 6 (ERK3)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16659] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300292,,,,,,,,"mitogen-activated protein kinase 6 (ERK3)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16659] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100318,,,,https://pharos.nih.gov/idg/targets/Q16659,,,,,,,,,,,,,MAPK6,ERK3|PRKM6,,Q16659,,,,,,,,Mitogen-activated protein kinase 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003321,"[""HCE cell""]",,Human corneal epithelial cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003221,,,,,,,,Human corneal epithelial cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003321,,,,,,,BrendaTissueOBO,,BTO:0003321,,,,,,,,,,,,,,,,,,,HCE cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400224,"[""SGK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400224,,,,,,,,,,,,,,,,,,,,,,,,,,,,SGK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003227,"[""SMMC-7721 cell""]",,Human hepatocellular carcinoma cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0000578|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human hepatocellular carcinoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003227,,,,,,,BrendaTissueOBO,SMMC7721 cell,BTO:0003227,,,,,,,,,,,,,,,,,,,SMMC-7721 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200131,"[""GPR112 gene""]",,"A G-protein coupled receptor 112 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,"A G-protein coupled receptor 112 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200131,,,,,,,,,,,,,,,,139378,GPR112,,,,,,,,,,,GPR112 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0110734,"[""neurodegeneration with brain iron accumulation""]",,"A neurodegenerative disease characterized by progressive iron accumulation in the basal ganglia and other regions of the brain, resulting in extrapyramidal movements, such as parkinsonism and dystonia.",false,,,http://purl.obolibrary.org/obo/DOID_1289,,,,,,,,"A neurodegenerative disease characterized by progressive iron accumulation in the basal ganglia and other regions of the brain, resulting in extrapyramidal movements, such as parkinsonism and dystonia.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0110734,,,,OMIM:PS234200|UMLS_CUI:C2931845|ORDO:385|ICD10CM:G23.0|MESH:C538421,NBIA,,,,DOID:0110734,,,,,,,,,,,,,,,,,,,neurodegeneration with brain iron accumulation,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200337,"[""MAP2K4 gene""]",,"This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400194,,,,,,,,"This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200337,,,,,,,,,,,,,,,,6416,MAP2K4,JNKK1|MEK4|MKK4,,,,,,,,,,MAP2K4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000171,"[""FLT3-autoinhibited kinase domain""]",,Fms-related tyrosine kinase 3; CD135; FLK2; FLK-2; FLT3; FLT-3; Ly72; STK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Fms-related tyrosine kinase 3; CD135; FLK2; FLK-2; FLT3; FLT-3; Ly72; STK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000171,,,,,,,,,,,,,,,,,,,200472,,,,,,,,,FLT3-autoinhibited kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1934,"[""dysostosis""]",,A bone development disease that results_in defective ossification of located_in bone.,false,,,http://purl.obolibrary.org/obo/DOID_0080006,,,,,,,,A bone development disease that results_in defective ossification of located_in bone.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1934,,,,SNOMEDCT_US_2016_03_01:109420003|NCI:C34560|UMLS_CUI:C0013393|MESH:D004413,,,disease_ontology,,DOID:1934,,,,,,,,,,,,,,,,,,,dysostosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002655,"[""postlarva""]",,The final juvenile stage. It is the only time in a lobster's life that it can swim forward.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000284,,,,,,,,The final juvenile stage. It is the only time in a lobster's life that it can swim forward.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002655,,,,,,,BrendaTissueOBO,postlarva stage,BTO:0002655,,,,,,,,,,,,,,,,,,,postlarva,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100288,"[""Mitogen-activated protein kinase kinase kinase 6""]",,"A mitogen-activated protein kinase kinase kinase 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95382] |mitogen-activated protein kinase kinase kinase 6 (M3K6)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300186,,,,,,,,"A mitogen-activated protein kinase kinase kinase 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95382] |mitogen-activated protein kinase kinase kinase 6 (M3K6)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100288,,,,https://pharos.nih.gov/idg/targets/O95382,,,,,,,,,,,,,MAP3K6,ASK2|MAPKKK6|MEKK6,,O95382,,,,,,,,Mitogen-activated protein kinase kinase kinase 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000739,"[""lymphoblastic leukemia cell line""]",,Lymphocytic leukemia cell line characterized by an abnormal increase in the number of lymphoblasts.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000773|http://purl.obolibrary.org/obo/BTO_0000741,,,,,,,,Lymphocytic leukemia cell line characterized by an abnormal increase in the number of lymphoblasts.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000739,,,,,,,BrendaTissueOBO,,BTO:0000739,,,,,,,,,,,,,,,,,,,lymphoblastic leukemia cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400505,"[""Gamma/CHRNG sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400505,,,,,,,,,,,,,,,,,,,,,,,,,,,,Gamma/CHRNG sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000300,"[""MTOR kinase domain""]",,Mechanistic target of rapamycin (serine/threonine kinase); FLJ44809; FRAP; FRAP1; FRAP2; MTOR; RAFT1; RAPT1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mechanistic target of rapamycin (serine/threonine kinase); FLJ44809; FRAP; FRAP1; FRAP2; MTOR; RAFT1; RAPT1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000300,,,,,,,,,,,,,,,,,,,200277,,,,,,,,,MTOR kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000033,"[""LEU1157 in MET(M1250T)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000033,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU1157 in MET(M1250T),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400055,"[""Bile acid receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400055,,,,,,,,,,,,,,,,,,,,,,,,,,,,Bile acid receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100162,"[""G protein-coupled receptor kinase 6""]",,"A G protein-coupled receptor kinase 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P43250] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300271,,,,,,,,"A G protein-coupled receptor kinase 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P43250] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100162,,,,https://pharos.nih.gov/idg/targets/P43250,,,,,,,,,,,,,GRK6,GPRK6,,P43250,,,,,,,,G protein-coupled receptor kinase 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300185,"[""STE-UNIQUE family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300113,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300185,,,,,,,,,,,,,,,,,,,,,,,,,,,,STE-UNIQUE family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000278,"[""MK14 kinase domain""]",,Mitogen-activated protein kinase 14; CSBP1; CSBP2; CSPB1; EXIP; MAPK14; Mxi2; p38; p38a; p38ALPHA; p38-alpha; PRKM14; PRKM15; RK; SAPK2A,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase 14; CSBP1; CSBP2; CSPB1; EXIP; MAPK14; Mxi2; p38; p38a; p38ALPHA; p38-alpha; PRKM14; PRKM15; RK; SAPK2A,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000278,,,,,,,,,,,,,,,,,,,200298,,,,,,,,,MK14 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000259,"[""chromaffin cell""]",,"A type of amine precursor uptake and decarboxylation cells that stain readily with chromium salts, their cytoplasmic granules taking on a characteristic brown color; they are found especially in cells of the adrenal medulla and in paraganglia of the coccygeal gland and carotid gland, along the sympathetic nerves, and in various organs. They contain chromaffin granules.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A type of amine precursor uptake and decarboxylation cells that stain readily with chromium salts, their cytoplasmic granules taking on a characteristic brown color; they are found especially in cells of the adrenal medulla and in paraganglia of the coccygeal gland and carotid gland, along the sympathetic nerves, and in various organs. They contain chromaffin granules.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000259,,,,,,,BrendaTissueOBO,pheochromocytes|pheochrome cell,BTO:0000259,,,,,,,,,,,,,,,,,,,chromaffin cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003797,"[""unicellular trichome""]",,Trichome that consists of one cell.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001395,,,,,,,,Trichome that consists of one cell.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003797,,,,,,,BrendaTissueOBO,,BTO:0003797,,,,,,,,,,,,,,,,,,,unicellular trichome,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002355,"[""calcaneal bone""]",,The irregular quadrangular bone at the back of the tarsus.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002343,,,,,,,,The irregular quadrangular bone at the back of the tarsus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002355,,,,,,,BrendaTissueOBO,calcaneum|os calcis|os tarsi fibulare|calcaneus|heel bone,BTO:0002355,,,,,,,,,,,,,,,,,,,calcaneal bone,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300583,"[""TRPM1 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300483,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300583,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPM1 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001178,"[""retinoblastoma cell""]",,"A malignant congenital blastoma, occurring in both hereditary and sporadic forms, composed of tumor cells arising from the retinoblasts, appearing in one or both eyes in children under 5 years of age, and usually diagnosed initially by a bright white or yellow pupillary reflex -leukokoria.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000579|http://purl.obolibrary.org/obo/BTO_0000526,,,,,,,,"A malignant congenital blastoma, occurring in both hereditary and sporadic forms, composed of tumor cells arising from the retinoblasts, appearing in one or both eyes in children under 5 years of age, and usually diagnosed initially by a bright white or yellow pupillary reflex -leukokoria.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001178,,,,,,,BrendaTissueOBO,glioma retinae cell,BTO:0001178,,,,,,,,,,,,,,,,,,,retinoblastoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100636,"[""Serine/threonine-protein kinase rio1""]",,"A serine/threonine-protein kinase RIO1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BRS2] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391037,,,,,,,,"A serine/threonine-protein kinase RIO1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BRS2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100636,,,,https://pharos.nih.gov/idg/targets/Q9BRS2,,,,,,,,,,,,,RIOK1,,,Q9BRS2,,,,,,,,Serine/threonine-protein kinase rio1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100161,"[""G-protein coupled receptor 161""]",,"A G-protein coupled receptor 161 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8N6U8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 161 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8N6U8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100161,,,,https://pharos.nih.gov/idg/targets/Q8N6U8,,,,,,,,,,,,,GPR161,,,Q8N6U8,,,,,,,,G-protein coupled receptor 161,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300171,"[""CAMK1 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300171,,,,,,,,,,,,,,,,,,,,,,,,,,,,CAMK1 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100017,"[""Neuronal acetylcholine receptor subunit beta-4""]",,"A neuronal acetylcholine receptor subunit beta-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30926] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300501,,,,,,,,"A neuronal acetylcholine receptor subunit beta-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30926] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100017,,,,https://pharos.nih.gov/idg/targets/P30926,,,,,,,,,,,,,CHRNB4,,,P30926,,,,,,,,Neuronal acetylcholine receptor subunit beta-4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200543,"[""TSSK4 gene""]",,"This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400238,,,,,,,,"This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200543,,,,,,,,,,,,,,,,283629,TSSK4,C14orf20|STK22E|TSSK5,,,,,,,,,,TSSK4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000176,"[""GCN2(Kin.Dom.2,S808G) kinase domain""]",,Eukaryotic translation initiation factor 2 alpha kinase 4; EIF2AK4; GCN2; KIAA1338,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Eukaryotic translation initiation factor 2 alpha kinase 4; EIF2AK4; GCN2; KIAA1338,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000176,,,,,,,,,,,,,,,,,,,200179,,,,,,,,,"GCN2(Kin.Dom.2,S808G) kinase domain",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002349,"[""hallux""]",,The first digit of the foot.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002348,,,,,,,,The first digit of the foot.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002349,,,,,,,BrendaTissueOBO,great toe|digitus primus (I) pedis,BTO:0002349,,,,,,,,,,,,,,,,,,,hallux,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000128,"[""EGFR(L858R,T790M) kinase domain""]",,"Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000128,,,,,,,,,,,,,,,,,,,200130,,,,,,,,,"EGFR(L858R,T790M) kinase domain",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117462,"[""Peroxisome proliferator-activated receptors""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00102000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117462,,,,,,,,,,,,,,,,,,,,,,,,,,,,Peroxisome proliferator-activated receptors,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100063,"[""Cyclin-dependent kinase 17""]",,"cyclin-dependent kinase 17 (PCTK2)  with  no mutation  in a nonphosphorylated state|A cyclin-dependent kinase 17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q00537] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300256,,,,,,,,"cyclin-dependent kinase 17 (PCTK2)  with  no mutation  in a nonphosphorylated state|A cyclin-dependent kinase 17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q00537] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100063,,,,https://pharos.nih.gov/idg/targets/Q00537,,,,,,,,,,,,,CDK17,PCTAIRE2|PCTK2,,Q00537,,,,,,,,Cyclin-dependent kinase 17,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000385,"[""bone cancer cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000374,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000385,,,,,,,BrendaTissueOBO,,BTO:0000385,,,,,,,,,,,,,,,,,,,bone cancer cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200665,"[""OR6N1 gene""]",,"An olfactory receptor 6N1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6N1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200665,,,,,,,,,,,,,,,,128372,OR6N1,,,,,,,,,,,OR6N1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117475,"[""Nerve growth factor ib-like receptors""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00102000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117475,,,,,,,,,,,,,,,,,,,,,,,,,,,,Nerve growth factor ib-like receptors,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001268,"[""somatic cell""]",,"One of the cells of the body that compose the tissues, organs, and parts of that individual other than the germ cells.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002322,,,,,,,,"One of the cells of the body that compose the tissues, organs, and parts of that individual other than the germ cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001268,,,,,,,BrendaTissueOBO,,BTO:0001268,,,,,,,,,,,,,,,,,,,somatic cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003620,"[""BMMC cell""]",,Bone marrow culture-derived mast cells.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000264|http://purl.obolibrary.org/obo/BTO_0001668,,,,,,,,Bone marrow culture-derived mast cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003620,,,,,,,BrendaTissueOBO,bone marrow mononuclear cell|bone marrow-derived mast cell,BTO:0003620,,,,,,,,,,,,,,,,,,,BMMC cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100444,"[""Px domain-containing protein kinase-like protein""]",,"A PX domain-containing protein kinase-like protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z7A4] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300215,,,,,,,,"A PX domain-containing protein kinase-like protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z7A4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100444,,,,https://pharos.nih.gov/idg/targets/Q7Z7A4,,,,,,,,,,,,,PXK,,,Q7Z7A4,,,,,,,,Px domain-containing protein kinase-like protein,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100259,"[""Mas-related G-protein coupled receptor member F""]",,"A mas-related G-protein coupled receptor F that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96AM1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300063,,,,,,,,"A mas-related G-protein coupled receptor F that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96AM1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100259,,,,https://pharos.nih.gov/idg/targets/Q96AM1,,,,,,,,,,,,,MRGPRF,GPR140|GPR168|MRGF,,Q96AM1,,,,,,,,Mas-related G-protein coupled receptor member F,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200007,"[""HTR2B gene""]",,"A 5-hydroxytryptamine receptor 2B that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41595] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402002,,,,,,,,"A 5-hydroxytryptamine receptor 2B that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41595] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200007,,,,,,,,,,,,,,,,3357,HTR2B,,,,,,,,,,,HTR2B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6204,"[""follicular adenoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2891,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6204,,,,MESH:D000236|UMLS_CUI:C0205647|SNOMEDCT_US_2016_03_01:55021007,Follicular adenoma (morphologic abnormality)|Follicular adenoma of the Thyroid gland|Thyroid follicular adenoma (disorder),,disease_ontology,,DOID:6204,,,,,,,,,,,,,,,,,,,follicular adenoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400511,"[""GABRA6 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400511,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRA6 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100017,"[""H835 in FLT3(D835H)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100017,,,,,,,,,,,,,,,,,,,,,,,,,,,,H835 in FLT3(D835H),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000903,"[""atrium""]",,"In the heart, the atrium is an upper chamber found on both sides of the heart. The left atrium receives red, oxygenated blood from the lungs by way of the pulmonary veins. The right atrium receives dark red blood from the other parts of the body.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"In the heart, the atrium is an upper chamber found on both sides of the heart. The left atrium receives red, oxygenated blood from the lungs by way of the pulmonary veins. The right atrium receives dark red blood from the other parts of the body.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000903,,,,,,,BrendaTissueOBO,cardiac atrium|atrial tissue,BTO:0000903,,,,,,,,,,,,,,,,,,,atrium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100477,"[""Olfactory receptor 1A1""]",,"An olfactory receptor 1A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P1Q5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P1Q5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100477,,,,https://pharos.nih.gov/idg/targets/Q9P1Q5,,,,,,,,,,,,,OR1A1,,,Q9P1Q5,,,,,,,,Olfactory receptor 1A1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050999,"[""autosomal recessive spinocerebellar ataxia 10""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0050950,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050999,lschriml,2015-10-07T14:43:23Z,,OMIM:613728,SCAR10,,disease_ontology,,DOID:0050999,,,,,,,,,,,,,,,,,,,autosomal recessive spinocerebellar ataxia 10,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100314,"[""Transmembrane channel-like protein 6""]",,"A transmembrane channel-like protein 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z403] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300329,,,,,,,,"A transmembrane channel-like protein 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z403] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100314,,,,https://pharos.nih.gov/idg/targets/Q7Z403,,,,,,,,,,,,,TMC6,EVER1|EVIN1,,Q7Z403,,,,,,,,Transmembrane channel-like protein 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060142,"[""form agnosia""]",,An agnosia that is a loss of the ability to perceive a whole object while perceiving only parts of details.,false,,,http://purl.obolibrary.org/obo/DOID_4090,,,,,,,,An agnosia that is a loss of the ability to perceive a whole object while perceiving only parts of details.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060142,lschriml,2011-08-22T12:04:56Z,,,,,disease_ontology,,DOID:0060142,,,,,,,,,,,,,,,,,,,form agnosia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060140,"[""cortical deafness""]",,An agnosia that is a loss of the ability to perceive any auditory information but whose hearing is intact.,false,,,http://purl.obolibrary.org/obo/DOID_4090,,,,,,,,An agnosia that is a loss of the ability to perceive any auditory information but whose hearing is intact.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060140,lschriml,2011-08-22T12:04:56Z,,,,,disease_ontology,,DOID:0060140,,,,,,,,,,,,,,,,,,,cortical deafness,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060145,"[""pain agnosia""]",,An agnosia that is a loss of the ability to perceive and process pain.,false,,,http://purl.obolibrary.org/obo/DOID_4090,,,,,,,,An agnosia that is a loss of the ability to perceive and process pain.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060145,lschriml,2011-08-22T12:04:56Z,,,analgesia,,disease_ontology,,DOID:0060145,,,,,,,,,,,,,,,,,,,pain agnosia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001142,"[""pulp""]",,"The soft, succulent part of a fruit usually composed of mesocarp.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The soft, succulent part of a fruit usually composed of mesocarp.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001142,,,,,,,BrendaTissueOBO,fruit pulp,BTO:0001142,,,,,,,,,,,,,,,,,,,pulp,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200514,"[""OR2B3 gene""]",,"An olfactory receptor 2B3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76000] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2B3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76000] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200514,,,,,,,,,,,,,,,,442184,OR2B3,OR2B3P,,,,,,,,,,OR2B3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1849,"[""cannabis dependence""]",,A drug dependence that involves the continued use of cannabis despite problems related to use of the substance.,false,,,http://purl.obolibrary.org/obo/DOID_9977,,,,,,,,A drug dependence that involves the continued use of cannabis despite problems related to use of the substance.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1849,,,,ICD9CM:304.3|MESH:D002189|ICD10CM:F12.2|SNOMEDCT_US_2016_03_01:85005007|NCI:C34445|SNOMEDCT_US_2016_03_01:191836005|SNOMEDCT_US_2016_03_01:191835009|UMLS_CUI:C0006870|SNOMEDCT_US_2016_03_01:268766005,,,disease_ontology,,DOID:1849,,,,,,,,,,,,,,,,,,,cannabis dependence,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000157,"[""FES kinase domain""]",,Feline sarcoma oncogene; FES; FPS,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Feline sarcoma oncogene; FES; FPS,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000157,,,,,,,,,,,,,,,,,,,200160,,,,,,,,,FES kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100465,"[""Serine/threonine-protein kinase sbk2""]",,"A serine/threonine-protein kinase SBK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C263] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300222,,,,,,,,"A serine/threonine-protein kinase SBK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C263] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100465,,,,https://pharos.nih.gov/idg/targets/P0C263,,,,,,,,,,,,,SBK2,SGK069,,P0C263,,,,,,,,Serine/threonine-protein kinase sbk2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000546,"[""gut mucosa""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000886,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000546,,,,,,,BrendaTissueOBO,,BTO:0000546,,,,,,,,,,,,,,,,,,,gut mucosa,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100382,"[""Olfactory receptor 4f17""]",,"An olfactory receptor 4F17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4F17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100382,,,,https://pharos.nih.gov/idg/targets/Q8NGA8,,,,,,,,,,,,,OR4F17,OR4F11P|OR4F18|OR4F19,,Q8NGA8,,,,,,,,Olfactory receptor 4f17,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400586,"[""TRPM4 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400483,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400586,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPM4 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200095,"[""CASK gene""]",,"This gene encodes a calcium/calmodulin-dependent serine protein kinase. The encoded protein is a MAGUK (membrane-associated guanylate kinase) protein family member. These proteins are scaffold proteins and the encoded protein is located at synapses in the brain. Mutations in this gene are associated with FG syndrome 4, mental retardation and microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400143,,,,,,,,"This gene encodes a calcium/calmodulin-dependent serine protein kinase. The encoded protein is a MAGUK (membrane-associated guanylate kinase) protein family member. These proteins are scaffold proteins and the encoded protein is located at synapses in the brain. Mutations in this gene are associated with FG syndrome 4, mental retardation and microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200095,,,,,,,,,,,,,,,,8573,CASK,LIN2,,,,,,,,,,CASK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9778,"[""irritable bowel syndrome""]",,"A syndrome that is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause.",false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,"A syndrome that is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9778,,,,ICD9CM:564.1|SNOMEDCT_US_2016_03_01:192434000|MESH:D043183|SNOMEDCT_US_2016_03_01:10743008|SNOMEDCT_US_2016_03_01:155783000|KEGG:05321|UMLS_CUI:C0022104|SNOMEDCT_US_2016_03_01:266525002|SNOMEDCT_US_2016_03_01:197124009|ICD10CM:K58.9|NCI:C82343|ICD10CM:K58,Irritable colon|IBD,,disease_ontology,Psychogenic IBS,DOID:9778,,,,,,,,,,,,,,,,,,,irritable bowel syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300419,"[""GRIK4 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300419,,,,,,,,,,,,,,,,,,,,,,,,,,,,GRIK4 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300401,"[""ClC-7/CLCN7 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300341,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300401,,,,,,,,,,,,,,,,,,,,,,,,,,,,ClC-7/CLCN7 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000189,"[""ICK kinase domain""]",,Intestinal cell (MAK-like) kinase; ECO; ICK; KIAA0936; LCK2; MGC46090; MRK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Intestinal cell (MAK-like) kinase; ECO; ICK; KIAA0936; LCK2; MGC46090; MRK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000189,,,,,,,,,,,,,,,,,,,200192,,,,,,,,,ICK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200236,"[""PRKCA gene""]",,"Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400276,,,,,,,,"Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200236,,,,,,,,,,,,,,,,5578,PRKCA,PKCA|PRKACA,,,,,,,,,,PRKCA gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6929,"[""retinal edema""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5679,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6929,,,,UMLS_CUI:C0242420|MESH:D010211|SNOMEDCT_US_2016_03_01:193426002|SNOMEDCT_US_2016_03_01:6141006|ICD10CM:H35.81|ICD9CM:362.83,,,disease_ontology,,DOID:6929,,,,,,,,,,,,,,,,,,,retinal edema,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000383,"[""renal cell carcinoma cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0003192|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000383,,,,,,,BrendaTissueOBO,renal cell adenocarcinoma cell line|hypernephroma cell line|RCC cell line|kidney adenocarcinoma cell line,BTO:0000383,,,,,,,,,,,,,,,,,,,renal cell carcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000265,"[""MAST1 kinase domain""]",,Microtubule associated serine/threonine kinase 1; KIAA0973; MAST1; SAST; SAST170,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Microtubule associated serine/threonine kinase 1; KIAA0973; MAST1; SAST; SAST170,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000265,,,,,,,,,,,,,,,,,,,200250,,,,,,,,,MAST1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100271,"[""Serine/threonine-protein kinase lmtk3""]",,"A serine/threonine-protein kinase LMTK3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96Q04] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300183,,,,,,,,"A serine/threonine-protein kinase LMTK3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96Q04] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100271,,,,https://pharos.nih.gov/idg/targets/Q96Q04,,,,,,,,,,,,,LMTK3,KIAA1883|TYKLM3,,Q96Q04,,,,,,,,Serine/threonine-protein kinase lmtk3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100241,"[""Potassium channel subfamily t member 2""]",,"A potassium channel subfamily T member 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q6UVM3] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300570,,,,,,,,"A potassium channel subfamily T member 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q6UVM3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100241,,,,https://pharos.nih.gov/idg/targets/Q6UVM3,,,,,,,,,,,,,KCNT2,SLICK,,Q6UVM3,,,,,,,,Potassium channel subfamily t member 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200755,"[""PTH2R gene""]",,"A parathyroid hormone 2 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49190] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400084|http://www.drugtargetontology.org/dto/DTO_02400003,,,,,,,,"A parathyroid hormone 2 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49190] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200755,,,,,,,,,,,,,,,,5746,PTH2R,PTHR2,,,,,,,,,,PTH2R gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200257,"[""MRGPRD gene""]",,"A mas-related G-protein coupled receptor D that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDS7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400063,,,,,,,,"A mas-related G-protein coupled receptor D that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDS7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200257,,,,,,,,,,,,,,,,116512,MRGPRD,MRGD,,,,,,,,,,MRGPRD gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200242,"[""LPAR5 gene""]",,"A lysophosphatidic acid receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H1C0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402007,,,,,,,,"A lysophosphatidic acid receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H1C0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200242,,,,,,,,,,,,,,,,57121,LPAR5,GPR92|GPR93,,,,,,,,,,LPAR5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000177,"[""BG-1 cell""]",,Ovarian adenocarcinoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001882,,,,,,,,Ovarian adenocarcinoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000177,,,,,,,BrendaTissueOBO,BG1 cell,BTO:0000177,,,,,,,,,,,,,,,,,,,BG-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400400,"[""ClC-6/CLCN6 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400341,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400400,,,,,,,,,,,,,,,,,,,,,,,,,,,,ClC-6/CLCN6 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100301,"[""Olfactory receptor 10G3""]",,"An olfactory receptor 10G3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10G3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100301,,,,https://pharos.nih.gov/idg/targets/Q8NGC4,,,,,,,,,,,,,OR10G3,,,Q8NGC4,,,,,,,,Olfactory receptor 10G3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100450,"[""Receptor-interacting serine/threonine-protein kinase 1""]",,A receptor-interacting serine/threonine-protein kinase 1 that is encoded in the genome of human. |receptor-interacting serine/threonine-protein kinase 1 (RIPK1)  with  no mutation  in a nonphosphorylated state,false,,,http://www.drugtargetontology.org/dto/DTO_03300124,,,,,,,,A receptor-interacting serine/threonine-protein kinase 1 that is encoded in the genome of human. |receptor-interacting serine/threonine-protein kinase 1 (RIPK1)  with  no mutation  in a nonphosphorylated state,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100450,,,,https://pharos.nih.gov/idg/targets/Q13546,,,,,,,,,,,,,RIPK1,RIP|RIP1,,Q13546,,,,,,,,Receptor-interacting serine/threonine-protein kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11030,"[""corneal edema""]",,,false,,,http://purl.obolibrary.org/obo/DOID_10124,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11030,,,,SNOMEDCT_US_2016_03_01:27194006|UMLS_CUI:C0010037|SNOMEDCT_US_2016_03_01:155158008|ICD9CM:371.2|MESH:D015715|SNOMEDCT_US_2016_03_01:193817005|NCI:C50508|SNOMEDCT_US_2016_03_01:193811006|ICD9CM:371.20|SNOMEDCT_US_2016_03_01:193812004|ICD10CM:H18.20,Corneal oedema,,disease_ontology,,DOID:11030,,,,,,,,,,,,,,,,,,,corneal edema,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11031,"[""bullous keratopathy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_11030,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11031,,,,SNOMEDCT_US_2016_03_01:193815002|ICD9CM:371.23|SNOMEDCT_US_2016_03_01:57207003|UMLS_CUI:C0155111|NCI:C26970|ICD10CM:H18.1,,,disease_ontology,,DOID:11031,,,,,,,,,,,,,,,,,,,bullous keratopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001622,"[""fibroblastoma cell""]",,"A cell of a tumor arising from fibroblasts, divided into fibromas and fibrosarcomas.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A cell of a tumor arising from fibroblasts, divided into fibromas and fibrosarcomas.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001622,,,,,,,BrendaTissueOBO,,BTO:0001622,,,,,,,,,,,,,,,,,,,fibroblastoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100021,"[""Muscarinic acetylcholine receptor m1""]",,"A muscarinic acetylcholine receptor M1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P11229] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300020,,,,,,,,"A muscarinic acetylcholine receptor M1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P11229] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100021,,,,https://pharos.nih.gov/idg/targets/P11229,,,,,,,,,,,,,CHRM1,,,P11229,,,,,,,,Muscarinic acetylcholine receptor m1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400386,"[""CACNA1F subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400333,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400386,,,,,,,,,,,,,,,,,,,,,,,,,,,,CACNA1F subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000159,"[""FGFR2 kinase domain""]",,Fibroblast growth factor receptor 2; BEK; BFR-1; CD332; CEK3; CFD1; ECT1; FGFR2; FLJ98662; JWS; KGFR; K-SAM; TK14; TK25,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Fibroblast growth factor receptor 2; BEK; BFR-1; CD332; CEK3; CFD1; ECT1; FGFR2; FLJ98662; JWS; KGFR; K-SAM; TK14; TK25,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000159,,,,,,,,,,,,,,,,,,,200162,,,,,,,,,FGFR2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100132,"[""Adhesion G-protein coupled receptor F3""]",,"A G-protein coupled receptor 113 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,"A G-protein coupled receptor 113 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100132,,,,https://pharos.nih.gov/idg/targets/Q8IZF5,,,,,,,,,,,,,GPR113,ADGRF3|PGR23,,Q8IZF5,,,,,,,,Adhesion G-protein coupled receptor F3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000339,"[""dental pulp""]",,The soft sensitive tissue that fills the central cavity of a tooth.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The soft sensitive tissue that fills the central cavity of a tooth.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000339,,,,,,,BrendaTissueOBO,dental pulp cell,BTO:0000339,,,,,,,,,,,,,,,,,,,dental pulp,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400187,"[""STE20 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400113,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400187,,,,,,,,,,,,,,,,,,,,,,,,,,,,STE20 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000215,"[""MET90 in M4K3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000215,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET90 in M4K3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001762,"[""neonate""]",,A newborn child; especially: a child less than a month old.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000284,,,,,,,,A newborn child; especially: a child less than a month old.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001762,,,,,,,BrendaTissueOBO,,BTO:0001762,,,,,,,,,,,,,,,,,,,neonate,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3111,"[""cystadenocarcinoma""]",,"An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, in which cystic accumulations of retained secretions are formed.",false,,,http://purl.obolibrary.org/obo/DOID_299,,,,,,,,"An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, in which cystic accumulations of retained secretions are formed.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3111,,,,UMLS_CUI:C0010631|SNOMEDCT_US_2016_03_01:21008007|NCI:C2971|SNOMEDCT_US_2016_03_01:189681005|MESH:D003536,cystadenocarcinoma NOS (morphologic abnormality)|cystadenocarcinoma (morphologic abnormality),,disease_ontology,,DOID:3111,,,,,,,,,,,,,,,,,,,cystadenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200562,"[""VRK1 gene""]",,"This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400243,,,,,,,,"This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200562,,,,,,,,,,,,,,,,7443,VRK1,,,,,,,,,,,VRK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200444,"[""PXK gene""]",,"This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400215,,,,,,,,"This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200444,,,,,,,,,,,,,,,,54899,PXK,,,,,,,,,,,PXK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000889,"[""Burkitt lymphoma cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0000104|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000889,,,,,,,BrendaTissueOBO,Burkitt's lymphoma cell line,BTO:0000889,,,,,,,,,,,,,,,,,,,Burkitt lymphoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100026,"[""Adrenocorticotropic hormone receptor""]",,"An adrenocorticotropic hormone receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q01718] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300021,,,,,,,,"An adrenocorticotropic hormone receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q01718] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100026,,,,https://pharos.nih.gov/idg/targets/Q01718,,,,,,,,,,,,,MC2R,ACTHR,,Q01718,,,,,,,,Adrenocorticotropic hormone receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200489,"[""STK17A gene""]",,"This gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400146,,,,,,,,"This gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200489,,,,,,,,,,,,,,,,9263,STK17A,DRAK1,,,,,,,,,,STK17A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000171,"[""MET438 in KGP1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000171,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET438 in KGP1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000335,"[""THR315 in ABL1(Q252H)-nonphosphorylated""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000335,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR315 in ABL1(Q252H)-nonphosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100284,"[""Ryanodine receptor 1""]",,"A ryanodine receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P21817] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300460,,,,,,,,"A ryanodine receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P21817] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100284,,,,https://pharos.nih.gov/idg/targets/P21817,,,,,,,,,,,,,RYR1,RYDR,,P21817,,,,,,,,Ryanodine receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100140,"[""G-protein coupled receptor 126""]",,"A G-protein coupled receptor 126 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86SQ4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,"A G-protein coupled receptor 126 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86SQ4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100140,,,,https://pharos.nih.gov/idg/targets/Q86SQ4,,,,,,,,,,,,,GPR126,ADGRG6|DREG|VIGR,,Q86SQ4,,,,,,,,G-protein coupled receptor 126,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200337,"[""TRPV5 gene""]",,"This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400594,,,,,,,,"This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200337,,,,,,,,,,,,,,,,56302,TRPV5,ECAC1,,,,,,,,,,TRPV5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000262,"[""PHE384 in CLK3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000262,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE384 in CLK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100266,"[""P2x purinoceptor 3""]",,"A P2X purinoceptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P56373] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300364,,,,,,,,"A P2X purinoceptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P56373] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100266,,,,https://pharos.nih.gov/idg/targets/P56373,,,,,,,,,,,,,P2RX3,,,P56373,,,,,,,,P2x purinoceptor 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400334,"[""Calcium channel auxiliary subunit types 1-4 (cca-) family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400334,,,,,,,,,,,,,,,,,,,,,,,,,,,,Calcium channel auxiliary subunit types 1-4 (cca-) family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000416,"[""epithelium""]",,"A membranous cellular tissue that covers a free surface or lines a tube or cavity of an animal body and serves especially to enclose and protect the other parts of the body, to produce secretions and excretions, and to function in assimilation.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000634,,,,,,,,"A membranous cellular tissue that covers a free surface or lines a tube or cavity of an animal body and serves especially to enclose and protect the other parts of the body, to produce secretions and excretions, and to function in assimilation.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000416,,,,,,,BrendaTissueOBO,,BTO:0000416,,,,,,,,,,,,,,,,,,,epithelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000431,"[""excretory gland""]",,"A gland that discharges its secretion through a duct opening on an internal or external surface of the body, as a lacrimal gland.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000522,,,,,,,,"A gland that discharges its secretion through a duct opening on an internal or external surface of the body, as a lacrimal gland.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000431,,,,,,,BrendaTissueOBO,,BTO:0000431,,,,,,,,,,,,,,,,,,,excretory gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100233,"[""Calcium/calmodulin-dependent protein kinase kinase 2""]",,"A calcium/calmodulin-dependent protein kinase kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RR4] |calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300275,,,,,,,,"A calcium/calmodulin-dependent protein kinase kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RR4] |calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100233,,,,https://pharos.nih.gov/idg/targets/Q96RR4,,,,,,,,,,,,,CAMKK2,CAMKKB|KIAA0787,,Q96RR4,,,,,,,,Calcium/calmodulin-dependent protein kinase kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000898,"[""myeloma cell""]",,A primary tumor cell of the bone marrow.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000583,,,,,,,,A primary tumor cell of the bone marrow.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000898,,,,,,,BrendaTissueOBO,,BTO:0000898,,,,,,,,,,,,,,,,,,,myeloma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100544,"[""Testis-specific serine/threonine-protein kinase 6""]",,"A testis-specific serine/threonine-protein kinase 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BXA6] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300238,,,,,,,,"A testis-specific serine/threonine-protein kinase 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BXA6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100544,,,,https://pharos.nih.gov/idg/targets/Q9BXA6,,,,,,,,,,,,,TSSK6,SSTK,,Q9BXA6,,,,,,,,Testis-specific serine/threonine-protein kinase 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400527,"[""GLRA3 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400409,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400527,,,,,,,,,,,,,,,,,,,,,,,,,,,,GLRA3 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100512,"[""Olfactory receptor 2a7""]",,"An olfactory receptor 2A7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R45] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2A7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R45] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100512,,,,https://pharos.nih.gov/idg/targets/Q96R45,,,,,,,,,,,,,OR2A7,,,Q96R45,,,,,,,,Olfactory receptor 2a7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2862,"[""glucosephosphate dehydrogenase deficiency""]",,A carbohydrate metabolic disorder that is characterised by abnormally low levels of glucose-6-phosphate dehydrogenase (abbreviated G6PD or G6PDH).,false,,,http://purl.obolibrary.org/obo/DOID_2978,,,,,,,,A carbohydrate metabolic disorder that is characterised by abnormally low levels of glucose-6-phosphate dehydrogenase (abbreviated G6PD or G6PDH).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2862,,,,SNOMEDCT_US_2016_03_01:154738008|NCI:C98933|MESH:D005955|SNOMEDCT_US_2016_03_01:124134002|SNOMEDCT_US_2016_03_01:62403005|SNOMEDCT_US_2016_03_01:267498002|UMLS_CUI:C2939465,deficiency of G-6PD|Glucose-6-phosphate dehydrogenase deficiency,,disease_ontology,,DOID:2862,,,,,,,,,,,,,,,,,,,glucosephosphate dehydrogenase deficiency,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000404,"[""SGK1 kinase domain""]",,Serine/threonine-protein kinase Sgk1; serum/glucocorticoid regulated kinase 1; SGK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase Sgk1; serum/glucocorticoid regulated kinase 1; SGK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000404,,,,,,,,,,,,,,,,,,,200476,,,,,,,,,SGK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1875,"[""impotence""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1876,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1875,,,,EFO:0004234,erectile dysfunction|Sexual impotence (finding),,disease_ontology,,DOID:1875,,,,,,,,,,,,,,,,,,,impotence,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200663,"[""OR6K6 gene""]",,"An olfactory receptor 6K6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGW6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6K6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGW6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200663,,,,,,,,,,,,,,,,128371,OR6K6,,,,,,,,,,,OR6K6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200167,"[""GPR179 gene""]",,"A G-protein coupled receptor 179 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6PRD1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400004,,,,,,,,"A G-protein coupled receptor 179 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6PRD1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200167,,,,,,,,,,,,,,,,440435,GPR179,GPR158L|GPR158L1,,,,,,,,,,GPR179 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2889,"[""retrocochlear disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2742,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2889,,,,MESH:D012181|UMLS_CUI:C0035352,,,disease_ontology,,DOID:2889,,,,,,,,,,,,,,,,,,,retrocochlear disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000043,"[""Farnesyl monophosphate""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000043,,,,,,,,,,,,,,,,,,,,,,,,,,,,Farnesyl monophosphate,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100028,"[""Acid-sensing ion channel 4""]",,"An acid-sensing ion channel 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96FT7] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300379,,,,,,,,"An acid-sensing ion channel 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96FT7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100028,,,,https://pharos.nih.gov/idg/targets/Q96FT7,,,,,,,,,,,,,ASIC4,ACCN4,,Q96FT7,,,,,,,,Acid-sensing ion channel 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100346,"[""Olfactory receptor 13d1""]",,"An olfactory receptor 13D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGV5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 13D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGV5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100346,,,,https://pharos.nih.gov/idg/targets/Q8NGV5,,,,,,,,,,,,,OR13D1,,,Q8NGV5,,,,,,,,Olfactory receptor 13d1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_75,"[""lymphatic system disease""]",,An immune system disease that is located_in the lymphatic system.,false,,,http://purl.obolibrary.org/obo/DOID_2914,,,,,,,,An immune system disease that is located_in the lymphatic system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:75,,,,SNOMEDCT_US_2016_03_01:234087005|SNOMEDCT_US_2016_03_01:266326002|SNOMEDCT_US_2016_03_01:155452000|SNOMEDCT_US_2016_03_01:111590001|SNOMEDCT_US_2016_03_01:3305006|MESH:D008206|SNOMEDCT_US_2016_03_01:362971004|UMLS_CUI:C0024228,"disorder of lymphatic system|lympoid system disease|disease of lympoid system|Lymphatic disease|Lymphangiopathy, NOS|lymphatic disorder|disorder of lymph node and lymphatics (disorder)|disorder of lymphoid system|Adenopathy|Lymphatic disorder",,disease_ontology,,DOID:75,,,,,,,,,,,,,,,,,,,lymphatic system disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_758,"[""situs inversus""]",,OMIM mapping confirmed by DO. [LS].,false,,,http://purl.obolibrary.org/obo/DOID_0050545,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:758,,,,ICD9CM:759.3|SNOMEDCT_US_2016_03_01:157025003|NCI:C87121|SNOMEDCT_US_2016_03_01:157033002|SNOMEDCT_US_2016_03_01:205770007|UMLS_CUI:C0037221|MESH:D012857|OMIM:270100|SNOMEDCT_US_2016_03_01:43876007|ICD10CM:Q89.3|SNOMEDCT_US_2016_03_01:254257004|SNOMEDCT_US_2016_03_01:205765000|SNOMEDCT_US_2016_03_01:268359006|SNOMEDCT_US_2016_03_01:27317008,Laterality sequence (disorder)|Complete transposition (morphologic abnormality)|situs inversus viscerum (disorder),,disease_ontology,,DOID:758,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,situs inversus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_750,"[""peptic ulcer disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_77,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:750,,,DOID:12635|DOID:11466|DOID:13115,SNOMEDCT_US_2016_03_01:196704007|MESH:D010437|SNOMEDCT_US_2016_03_01:155701001|ICD10CM:K27|SNOMEDCT_US_2016_03_01:266437002|SNOMEDCT_US_2016_03_01:155710009|SNOMEDCT_US_2016_03_01:266501005|SNOMEDCT_US_2016_03_01:13200003|UMLS_CUI:C0030920|SNOMEDCT_US_2016_03_01:196697002|SNOMEDCT_US_2016_03_01:196681007|SNOMEDCT_US_2016_03_01:196705008|ICD9CM:533|NCI:C3318,acute peptic ulcer with hemorrhage and perforation|acute peptic ulcer without hemorrhage AND without perforation (disorder)|acute peptic ulcer without hemorrhage and without perforation|acute peptic ulcer with hemorrhage,,disease_ontology,,DOID:750,,,,,,,,,,,,,,,,,,,peptic ulcer disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_752,"[""peptic ulcer perforation""]",,,false,,,http://purl.obolibrary.org/obo/DOID_750,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:752,,,DOID:751,UMLS_CUI:C0030925|MESH:D010439|SNOMEDCT_US_2016_03_01:88169003|SNOMEDCT_US_2016_03_01:155703003|SNOMEDCT_US_2016_03_01:266502003|SNOMEDCT_US_2016_03_01:196700003,acute peptic ulcer with perforation|Peptic ulcer with perforation (disorder)|Perforated peptic ulcer|Unspecified peptic ulcer with perforation (disorder),,disease_ontology,,DOID:752,,,,,,,,,,,,,,,,,,,peptic ulcer perforation,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200795,"[""TAS2R4 gene""]",,"A taste receptor type 2 member 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400014,,,,,,,,"A taste receptor type 2 member 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200795,,,,,,,,,,,,,,,,50832,TAS2R4,,,,,,,,,,,TAS2R4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000009,"[""GLN108 in ERK3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30011,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000009,,,,,,,,,,,,,,,,,,,,,,,,,,,,GLN108 in ERK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000163,"[""FGR kinase domain""]",,Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; c-fgr; c-src2; FGR; FLJ43153; MGC75096; p55c-fgr; p55-Fgr; p58c-fgr; SRC2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; c-fgr; c-src2; FGR; FLJ43153; MGC75096; p55c-fgr; p55-Fgr; p58c-fgr; SRC2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000163,,,,,,,,,,,,,,,,,,,200166,,,,,,,,,FGR kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100070,"[""Chloride channel protein clc-ka""]",,"A chloride channel protein ClC-Ka that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51800] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300393,,,,,,,,"A chloride channel protein ClC-Ka that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51800] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100070,,,,https://pharos.nih.gov/idg/targets/P51800,,,,,,,,,,,,,CLCNKA,,,P51800,,,,,,,,Chloride channel protein clc-ka,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2725,"[""capillary hemangioma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_471|http://purl.obolibrary.org/obo/DOID_1271,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2725,,,,MESH:D018324|SNOMEDCT_US_2016_03_01:83343001|SNOMEDCT_US_2016_03_01:254206003|NCI:C6645|SNOMEDCT_US_2016_03_01:205560007|SNOMEDCT_US_2016_03_01:56975005|SNOMEDCT_US_2016_03_01:402867006|ICD10CM:Q82.5|UMLS_CUI:C0206733,Congenital vascular naevus|Capillary hemangioma (disorder)|Strawberry nevus|Strawberry nevus of skin (disorder)|Infantile hemangioma|Congenital vascular hamartoma|cellular hemangioma of Infancy (Strawberry nevus)|Strawberry haemangioma|Capillary hemangioma (morphologic abnormality)|Juvenile hemangioma,,disease_ontology,,DOID:2725,,,,,,,,,,,,,,,,,,,capillary hemangioma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100212,"[""Casein kinase i isoform gamma-2""]",,"casein kinase i isoform gamma-2 (KC1G2)  with  no mutation  in a nonphosphorylated state|A casein kinase I isoform gamma-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P78368] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300170,,,,,,,,"casein kinase i isoform gamma-2 (KC1G2)  with  no mutation  in a nonphosphorylated state|A casein kinase I isoform gamma-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P78368] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100212,,,,https://pharos.nih.gov/idg/targets/P78368,,,,,,,,,,,,,CSNK1G2,CK1G2,,P78368,,,,,,,,Casein kinase i isoform gamma-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200123,"[""GLP2R gene""]",,"A glucagon-like peptide 2 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95838] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400047,,,,,,,,"A glucagon-like peptide 2 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95838] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200123,,,,,,,,,,,,,,,,9340,GLP2R,,,,,,,,,,,GLP2R gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000030,"[""LEU111 in NEK7""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000030,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU111 in NEK7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200342,"[""ZACN gene""]",,"LGICZ1 is a zinc-activated ligand-gated ion channel that defines a new subgroup of the cysteine-loop superfamily of ligand-gated ion channels (Davies et al., 2003 [PubMed 12381728]).[supplied by OMIM, Mar 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400328,,,,,,,,"LGICZ1 is a zinc-activated ligand-gated ion channel that defines a new subgroup of the cysteine-loop superfamily of ligand-gated ion channels (Davies et al., 2003 [PubMed 12381728]).[supplied by OMIM, Mar 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200342,,,,,,,,,,,,,,,,353174,ZACN,L2|LGICZ|LGICZ1|ZAC,,,,,,,,,,ZACN gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100568,"[""Olfactory receptor 4B1""]",,"An olfactory receptor 4B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100568,,,,https://pharos.nih.gov/idg/targets/Q8NGF8,,,,,,,,,,,,,OR4B1,,,Q8NGF8,,,,,,,,Olfactory receptor 4B1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100486,"[""Srsf protein kinase 1""]",,"SRSF protein kinase 1 (SRPK1)  with  no mutation  in a nonphosphorylated state|An SRSF protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96SB4] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300226,,,,,,,,"SRSF protein kinase 1 (SRPK1)  with  no mutation  in a nonphosphorylated state|An SRSF protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96SB4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100486,,,,https://pharos.nih.gov/idg/targets/Q96SB4,,,,,,,,,,,,,SRPK1,,,Q96SB4,,,,,,,,Srsf protein kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100328,"[""Transient receptor potential cation channel subfamily M member 3""]",,"A transient receptor potential cation channel subfamily M member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HCF6] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300585,,,,,,,,"A transient receptor potential cation channel subfamily M member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HCF6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100328,,,,https://pharos.nih.gov/idg/targets/Q9HCF6,,,,,,,,,,,,,TRPM3,KIAA1616|LTRPC3,,Q9HCF6,,,,,,,,Transient receptor potential cation channel subfamily M member 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000744,"[""lymphocytic leukemia cell""]",,"Leukemia cell of either of two types marked by an abnormal increase in the number of white blood cells (as lymphocytes) which accumulate in bone marrow, lymphoid tissue (as of the lymph nodes and spleen), and circulating blood.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001271,,,,,,,,"Leukemia cell of either of two types marked by an abnormal increase in the number of white blood cells (as lymphocytes) which accumulate in bone marrow, lymphoid tissue (as of the lymph nodes and spleen), and circulating blood.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000744,,,,,,,BrendaTissueOBO,"leukemia cell, lymphocytic|lymphoid leukemia cell|lymphatic leukemia cell",BTO:0000744,,,,,,,,,,,,,,,,,,,lymphocytic leukemia cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217472,"[""Estrogen receptors gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00200002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217472,,,,,,,,,,,,,,,,,,,,,,,,,,,,Estrogen receptors gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002597,"[""NUGC-3 cell""]",,Human gastric adenocarcinoma cell line established from a 72-year-old male.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002380,,,,,,,,Human gastric adenocarcinoma cell line established from a 72-year-old male.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002597,,,,,,,BrendaTissueOBO,NUGC3 cell,BTO:0002597,,,,,,,,,,,,,,,,,,,NUGC-3 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005094,"[""leaf sheath""]",,The basal part of a grass leaf that encircles the stem.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The basal part of a grass leaf that encircles the stem.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005094,XPMUser,2011-03-08T09:45:57Z,,,,,BrendaTissueOBO,,BTO:0005094,,,,,,,,,,,,,,,,,,,leaf sheath,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117507,"[""Photoreceptor-specific nuclear receptor""]",,"A photoreceptor-specific nuclear receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y5X4] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117470,,,,,,,,"A photoreceptor-specific nuclear receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y5X4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117507,,,,https://pharos.nih.gov/idg/targets/Q9Y5X4,,,,,,,,,,,,,NR2E3,RNR,,Q9Y5X4,,,,,,,,Photoreceptor-specific nuclear receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000435,"[""TIE2 kinase domain""]",,"Angiopoietin-1 receptor; TEK tyrosine kinase, endothelial; CD202B; TEK; TIE2; TIE-2; VMCM; VMCM1",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Angiopoietin-1 receptor; TEK tyrosine kinase, endothelial; CD202B; TEK; TIE2; TIE-2; VMCM; VMCM1",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000435,,,,,,,,,,,,,,,,,,,200436,,,,,,,,,TIE2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1206,"[""Rett syndrome""]",,"A pervasive developmental disease that is characterized by normal early growth and development followed by a slowing of development, loss of purposeful use of the hands, distinctive hand movements, slowed brain and head growth, problems with walking, seizures, and intellectual disability.",false,,,http://purl.obolibrary.org/obo/DOID_0060040,,,,,,,,"A pervasive developmental disease that is characterized by normal early growth and development followed by a slowing of development, loss of purposeful use of the hands, distinctive hand movements, slowed brain and head growth, problems with walking, seizures, and intellectual disability.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1206,,,,OMIM:613454|MESH:D015518|SNOMEDCT_US_2016_03_01:68618008|ICD10CM:F84.2|SNOMEDCT_US_2016_03_01:192583003|UMLS_CUI:C0035372|OMIM:312750|NCI:C75488,Rett's disorder|cerebroatrophic hyperammonemia,,disease_ontology,,DOID:1206,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Rett syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2891,"[""thyroid adenoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060089|http://purl.obolibrary.org/obo/DOID_657|http://purl.obolibrary.org/obo/DOID_50,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2891,,,,SNOMEDCT_US_2016_03_01:154623004|UMLS_CUI:C0151468|SNOMEDCT_US_2016_03_01:255033000|SNOMEDCT_US_2016_03_01:269644003|SNOMEDCT_US_2016_03_01:189174004|MESH:D013964|NCI:C3502|SNOMEDCT_US_2016_03_01:255034006,adenoma of thyroid gland,,disease_ontology,,DOID:2891,,,,,,,,,,,,,,,,,,,thyroid adenoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200693,"[""OR8D4 gene""]",,"An olfactory receptor 8D4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGM9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 8D4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGM9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200693,,,,,,,,,,,,,,,,338662,OR8D4,,,,,,,,,,,OR8D4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200020,"[""CHRNE gene""]",,"Acetylcholine receptors at mature mammalian neuromuscular junctions are pentameric protein complexes composed of four subunits in the ratio of two alpha subunits to one beta, one epsilon, and one delta subunit. The acetylcholine receptor changes subunit composition shortly after birth when the epsilon subunit replaces the gamma subunit seen in embryonic receptors. Mutations in the epsilon subunit are associated with congenital myasthenic syndrome. [provided by RefSeq, Sep 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400504,,,,,,,,"Acetylcholine receptors at mature mammalian neuromuscular junctions are pentameric protein complexes composed of four subunits in the ratio of two alpha subunits to one beta, one epsilon, and one delta subunit. The acetylcholine receptor changes subunit composition shortly after birth when the epsilon subunit replaces the gamma subunit seen in embryonic receptors. Mutations in the epsilon subunit are associated with congenital myasthenic syndrome. [provided by RefSeq, Sep 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200020,,,,,,,,,,,,,,,,1145,CHRNE,ACHRE,,,,,,,,,,CHRNE gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300328,"[""Neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300328,,,,,,,,,,,,,,,,,,,,,,,,,,,,"Neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002730,"[""uterine serous carcinoma cell""]",,Uterine serous carcinoma is an uncommon form of endometrial cancer that typically arises in postmenopausal women.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000257,,,,,,,,Uterine serous carcinoma is an uncommon form of endometrial cancer that typically arises in postmenopausal women.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002730,,,,,,,BrendaTissueOBO,uterine serous adenocarcinoma cell|uterine papillary serous carcinoma cell|USC cell|UPSC cell,BTO:0002730,,,,,,,,,,,,,,,,,,,uterine serous carcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80271,"[""Glucagon-like peptide 2""]",GLP-2,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG COMPOUND:C16049,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,GLP-2,,,CHEBI:80271,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80271,,,,,Glucagon-like peptide 2,,CHEBI:80271,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003305,"[""epipodite""]",,The outer branch of the legs in certain Crustacea.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The outer branch of the legs in certain Crustacea.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003305,Marion,2010-01-29T11:02:36Z,,,,,BrendaTissueOBO,,BTO:0003305,,,,,,,,,,,,,,,,,,,epipodite,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100154,"[""ATP-sensitive inward rectifier potassium channel 15""]",,"An ATP-sensitive inward rectifier potassium channel 15 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99712] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300426,,,,,,,,"An ATP-sensitive inward rectifier potassium channel 15 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99712] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100154,,,,https://pharos.nih.gov/idg/targets/Q99712,,,,,,,,,,,,,KCNJ15,KCNJ14,,Q99712,,,,,,,,ATP-sensitive inward rectifier potassium channel 15,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001758,"[""ocellus""]",,"A small simple eye, found in many invertebrates, usually consisting of a few sensory cells and a single lens.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000439,,,,,,,,"A small simple eye, found in many invertebrates, usually consisting of a few sensory cells and a single lens.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001758,,,,,,,BrendaTissueOBO,,BTO:0001758,,,,,,,,,,,,,,,,,,,ocellus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000891,"[""NTERA-2 cell""]",,Human embryonal carcinoma (teratocarcinoma). NTERA-2 was cloned from cell line TERA-2 which was derived from a metastatic teratocarcinoma of a 22-year-old Caucasian male.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000306,,,,,,,,Human embryonal carcinoma (teratocarcinoma). NTERA-2 was cloned from cell line TERA-2 which was derived from a metastatic teratocarcinoma of a 22-year-old Caucasian male.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000891,,,,,,,BrendaTissueOBO,NT-2 cell|NT2 cell,BTO:0000891,,,,,,,,,,,,,,,,,,,NTERA-2 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117523,"[""Steroidogenic factor 1""]",,A steroidogenic factor 1 that is encoded in the genome of human. [PRO:CNA] ,false,,,http://www.drugtargetontology.org/dto/DTO_00117476,,,,,,,,A steroidogenic factor 1 that is encoded in the genome of human. [PRO:CNA] ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117523,,,,https://pharos.nih.gov/idg/targets/Q13285,,,,,,,,,,,,,NR5A1,FTZF1,,Q13285,,,,,,,,Steroidogenic factor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100383,"[""Protein-associating with the carboxyl-terminal domain of ezrin""]",,"A protein-associating with the carboxyl-terminal domain of ezrin that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZE3] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300199,,,,,,,,"A protein-associating with the carboxyl-terminal domain of ezrin that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZE3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100383,,,,https://pharos.nih.gov/idg/targets/Q8IZE3,,,,,,,,,,,,,SCYL3,PACE1,,Q8IZE3,,,,,,,,Protein-associating with the carboxyl-terminal domain of ezrin,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100042,"[""Voltage-dependent r-type calcium channel subunit alpha-1e""]",,"A voltage-dependent R-type calcium channel subunit alpha-1E that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15878] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300385,,,,,,,,"A voltage-dependent R-type calcium channel subunit alpha-1E that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15878] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100042,,,,https://pharos.nih.gov/idg/targets/Q15878,,,,,,,,,,,,,CACNA1E,CACH6|CACNL1A6,,Q15878,,,,,,,,Voltage-dependent r-type calcium channel subunit alpha-1e,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100102,"[""Frizzled-10""]",,"A frizzled-10 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9ULW2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300043,,,,,,,,"A frizzled-10 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9ULW2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100102,,,,https://pharos.nih.gov/idg/targets/Q9ULW2,,,,,,,,,,,,,FZD10,,,Q9ULW2,,,,,,,,Frizzled-10,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80329,"[""Pancreatic polypeptide""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16117,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80329,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80329,,,,,Pancreatic polypeptide,,CHEBI:80329,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000330,"[""THR315 in ABL1(F317L)-phosphorylated""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000330,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR315 in ABL1(F317L)-phosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200154,"[""GPR151 gene""]",,"A G-protein coupled receptor 151 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDV0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 151 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDV0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200154,,,,,,,,,,,,,,,,134391,GPR151,PGR7,,,,,,,,,,GPR151 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400454,"[""NR3B/GRIN3B subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400454,,,,,,,,,,,,,,,,,,,,,,,,,,,,NR3B/GRIN3B subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400568,"[""Kv9.3/KCNS3 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400450,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400568,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv9.3/KCNS3 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200598,"[""AK5 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200598,,,,,,,,,,,,,,,,,,,,,,,,,,,,AK5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100055,"[""T351 in ABL1(M351T)-phosphorylated""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100055,,,,,,,,,,,,,,,,,,,,,,,,,,,,T351 in ABL1(M351T)-phosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400583,"[""TRPM1 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400483,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400583,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPM1 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400450,"[""S subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400450,,,,,,,,,,,,,,,,,,,,,,,,,,,,S subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000033,"[""ADCK3 kinase domain""]",,"Chaperone, ABC1 activity of bc1 complex homolog (S. pombe); ADCK3; ARCA2; CABC1; COQ8; MGC4849; SCAR9",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Chaperone, ABC1 activity of bc1 complex homolog (S. pombe); ADCK3; ARCA2; CABC1; COQ8; MGC4849; SCAR9",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000033,,,,,,,,,,,,,,,,,,,200032,,,,,,,,,ADCK3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001553,"[""LS-174T cell""]",,Human Caucasian colon adenocarcinoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001913,,,,,,,,Human Caucasian colon adenocarcinoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001553,,,,,,,BrendaTissueOBO,LS 174T cell|LS174T cell,BTO:0001553,,,,,,,,,,,,,,,,,,,LS-174T cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000161,"[""MET344 in PAK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000161,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET344 in PAK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117505,"[""Nuclear receptor subfamily 2 group c member 2""]",,"A nuclear receptor subfamily 2 group C member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49116] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117469,,,,,,,,"A nuclear receptor subfamily 2 group C member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49116] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117505,,,,https://pharos.nih.gov/idg/targets/P49116,,,,,,,,,,,,,NR2C2,TR4,,P49116,,,,,,,,Nuclear receptor subfamily 2 group c member 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3516,"[""adult fibrosarcoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3516,,,,NCI:C7809|UMLS_CUI:C0278595,,,disease_ontology,,DOID:3516,,,,,,,,,,,,,,,,,,,adult fibrosarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02302001,"[""5-HT1 receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300017,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02302001,,,,,,,,,,,,,,,,,,,,,,,,,,,,5-HT1 receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200175,"[""GPRC6A gene""]",,"A G-protein coupled receptor family C group 6 member A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5T6X5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400029,,,,,,,,"A G-protein coupled receptor family C group 6 member A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5T6X5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200175,,,,,,,,,,,,,,,,222545,GPRC6A,,,,,,,,,,,GPRC6A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100723,"[""Oxoeicosanoid receptor 1""]",,"An oxoeicosanoid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDS5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"An oxoeicosanoid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDS5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100723,,,,https://pharos.nih.gov/idg/targets/Q8TDS5,,,,,,,,,,,,,OXER1,GPR170|TG1019,,Q8TDS5,,,,,,,,Oxoeicosanoid receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005125,"[""sternocleidomastoid muscle""]",,In human anatomy is a paired muscle in the superficial layers of the anterior portion of the neck. It acts to flex and rotate the head.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000021,,,,,,,,In human anatomy is a paired muscle in the superficial layers of the anterior portion of the neck. It acts to flex and rotate the head.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005125,XPMUser,2011-05-06T10:33:36Z,,,,,BrendaTissueOBO,sternocleidomastoid|sternocleidomastoideus,BTO:0005125,,,,,,,,,,,,,,,,,,,sternocleidomastoid muscle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1283,"[""enterocele""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1284|http://purl.obolibrary.org/obo/DOID_1285,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1283,,,,ICD9CM:618.6|SNOMEDCT_US_2016_03_01:47671001|SNOMEDCT_US_2016_03_01:398061002|ICD10CM:K46|SNOMEDCT_US_2016_03_01:198275001|MESH:D006547|UMLS_CUI:C0205792|ICD10CM:N81.5|SNOMEDCT_US_2016_03_01:270884000|SNOMEDCT_US_2016_03_01:198272003,vaginal enterocele,,disease_ontology,,DOID:1283,,,,,,,,,,,,,,,,,,,enterocele,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12835,"[""quadriplegia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_331,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12835,,,,ICD10CM:G82.50|ICD10CM:G82.5|NCI:C50721|ICD9CM:344.00|SNOMEDCT_US_2016_03_01:155030003|MESH:D011782|SNOMEDCT_US_2016_03_01:11538006|UMLS_CUI:C0034372,tetraplegia,,disease_ontology,,DOID:12835,,,,,,,,,,,,,,,,,,,quadriplegia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100294,"[""Sodium channel subunit beta-3""]",,"A sodium channel subunit beta-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NY72] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300468,,,,,,,,"A sodium channel subunit beta-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NY72] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100294,,,,https://pharos.nih.gov/idg/targets/Q9NY72,,,,,,,,,,,,,SCN3B,KIAA1158,,Q9NY72,,,,,,,,Sodium channel subunit beta-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300490,"[""Alpha-10/CHRNA10 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300490,,,,,,,,,,,,,,,,,,,,,,,,,,,,Alpha-10/CHRNA10 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004483,"[""ovarian surface epithelium""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003661,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004483,Marion,2010-02-04T12:03:36Z,,,,,BrendaTissueOBO,,BTO:0004483,,,,,,,,,,,,,,,,,,,ovarian surface epithelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000097,"[""MET105 in TAOK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000097,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET105 in TAOK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1919,"[""Lesch-Nyhan syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_653,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1919,,,,SNOMEDCT_US_2016_03_01:190918000|SNOMEDCT_US_2016_03_01:68655008|SNOMEDCT_US_2016_03_01:10406007|NCI:C61255|SNOMEDCT_US_2016_03_01:124275001|SNOMEDCT_US_2016_03_01:267451005|MESH:D007926|OMIM:300322|SNOMEDCT_US_2016_03_01:190921003|ICD10CM:E79.1|SNOMEDCT_US_2016_03_01:90924007|UMLS_CUI:C0023374|SNOMEDCT_US_2016_03_01:190917005,X-linked hyperuricemia (disorder) [Ambiguous]|Hypoxanthine-guanine phosphoribosyltransferase deficiency (disorder) [Ambiguous]|hypoxanthine guanine phosphoribosyltransferase deficiency|HG-PRT deficiency|Lesch - Nyhan syndrome|Complete hypoxanthine-guanine phosphoribosyltransferase deficiency|Lesch-Nyhan syndrome (disorder)|Hypoxanthine-guanine phosphoribosyltransferase deficiency (disorder)|deficiency of IMP pyrophosphorylase|Hypoxanthine-guanine-phosphoribosyltransferase deficiency (& [Lesch - Nyhan syndrome]),,disease_ontology,,DOID:1919,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Lesch-Nyhan syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100223,"[""Potassium channel subfamily k member 13""]",,"A potassium channel subfamily K member 13 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HB14] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300359,,,,,,,,"A potassium channel subfamily K member 13 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HB14] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100223,,,,https://pharos.nih.gov/idg/targets/Q9HB14,,,,,,,,,,,,,KCNK13,,,Q9HB14,,,,,,,,Potassium channel subfamily k member 13,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117522,"[""Nuclear receptor subfamily 4 group a member 3""]",,"A nuclear receptor subfamily 4 group A member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92570] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117475,,,,,,,,"A nuclear receptor subfamily 4 group A member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92570] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117522,,,,https://pharos.nih.gov/idg/targets/Q92570,,,,,,,,,,,,,NR4A3,CSMF,,Q92570,,,,,,,,Nuclear receptor subfamily 4 group a member 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5353,"[""colonic disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5295,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5353,,,DOID:10758,MESH:D003108|SNOMEDCT_US_2016_03_01:128524007|UMLS_CUI:C0009373,colon disorder,,disease_ontology,,DOID:5353,,,,,,,,,,,,,,,,,,,colonic disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9822,"[""partial central choroid dystrophy""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_9794,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9822,,,,OMIM:613105|SNOMEDCT_US_2016_03_01:193468002|UMLS_CUI:C0339427|SNOMEDCT_US_2016_03_01:80526002|ICD9CM:363.53,"Choroidal dystrophy, central areolar",,disease_ontology,,DOID:9822,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,partial central choroid dystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300472,"[""SCN7A subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300369,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300472,,,,,,,,,,,,,,,,,,,,,,,,,,,,SCN7A subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300230,"[""TK-UNIQUE family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300230,,,,,,,,,,,,,,,,,,,,,,,,,,,,TK-UNIQUE family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000140,"[""EPHA8 kinase domain""]",,EPH receptor A8; EEK; EK3; EPHA8; HEK3; KIAA1459,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,EPH receptor A8; EEK; EK3; EPHA8; HEK3; KIAA1459,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000140,,,,,,,,,,,,,,,,,,,200142,,,,,,,,,EPHA8 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400481,"[""Two pore calcium channel subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400333,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400481,,,,,,,,,,,,,,,,,,,,,,,,,,,,Two pore calcium channel subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_6102,"[""Kallidin""]","FYSKZKQBTVLYEQ-FSLKYBNLSA-N|C56H85N17O12|NCCCC[C@H](N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O|InChI=1S/C56H85N17O12/c57-24-8-7-18-36(58)46(76)67-37(19-9-25-63-55(59)60)51(81)73-29-13-23-44(73)53(83)72-28-11-21-42(72)49(79)65-32-45(75)66-39(30-34-14-3-1-4-15-34)47(77)70-41(33-74)52(82)71-27-12-22-43(71)50(80)69-40(31-35-16-5-2-6-17-35)48(78)68-38(54(84)85)20-10-26-64-56(61)62/h1-6,14-17,36-44,74H,7-13,18-33,57-58H2,(H,65,79)(H,66,75)(H,67,76)(H,68,78)(H,69,80)(H,70,77)(H,84,85)(H4,59,60,63)(H4,61,62,64)/t36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1|Lysyl-bradykinin|Lysylbradykinin|1187.656|0|1188.383",,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C01505|CAS:342-10-9,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kallidin,,chebi_ontology,"FYSKZKQBTVLYEQ-FSLKYBNLSA-N|C56H85N17O12|NCCCC[C@H](N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O|InChI=1S/C56H85N17O12/c57-24-8-7-18-36(58)46(76)67-37(19-9-25-63-55(59)60)51(81)73-29-13-23-44(73)53(83)72-28-11-21-42(72)49(79)65-32-45(75)66-39(30-34-14-3-1-4-15-34)47(77)70-41(33-74)52(82)71-27-12-22-43(71)50(80)69-40(31-35-16-5-2-6-17-35)48(78)68-38(54(84)85)20-10-26-64-56(61)62/h1-6,14-17,36-44,74H,7-13,18-33,57-58H2,(H,65,79)(H,66,75)(H,67,76)(H,68,78)(H,69,80)(H,70,77)(H,84,85)(H4,59,60,63)(H4,61,62,64)/t36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1|Lysyl-bradykinin|Lysylbradykinin|1187.656|0|1188.383",,,CHEBI:6102,,,,,,,,,,,,,,,,,,,,,,,CHEBI:6102,,,,,Kallidin,,CHEBI:6102,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200086,"[""EDNRA gene""]",,"An endothelin-1 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25101] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400098,,,,,,,,"An endothelin-1 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25101] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200086,,,,,,,,,,,,,,,,1909,EDNRA,ETA|ETRA,,,,,,,,,,EDNRA gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300318,"[""TAO subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300187,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300318,,,,,,,,,,,,,,,,,,,,,,,,,,,,TAO subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100358,"[""Serine/threonine-protein kinase nek4""]",,"serine/threonine-protein kinase nek4 (NEK4)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase Nek4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51957] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300197,,,,,,,,"serine/threonine-protein kinase nek4 (NEK4)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase Nek4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51957] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100358,,,,https://pharos.nih.gov/idg/targets/P51957,,,,,,,,,,,,,NEK4,STK2,,P51957,,,,,,,,Serine/threonine-protein kinase nek4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200021,"[""CHRNG gene""]",,"The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.[provided by RefSeq, Sep 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400505,,,,,,,,"The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.[provided by RefSeq, Sep 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200021,,,,,,,,,,,,,,,,1146,CHRNG,ACHRG,,,,,,,,,,CHRNG gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1483,"[""gingival disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3388,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1483,,,,MESH:D005882|SNOMEDCT_US_2016_03_01:266489007|SNOMEDCT_US_2016_03_01:155642009|UMLS_CUI:C0017563|SNOMEDCT_US_2016_03_01:18718003,,,disease_ontology,,DOID:1483,,,,,,,,,,,,,,,,,,,gingival disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6432,"[""pulmonary hypertension""]",,"A hypertension characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein or pulmonary capillaries.",false,,,http://purl.obolibrary.org/obo/DOID_10763,,,,,,,,"A hypertension characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein or pulmonary capillaries.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6432,,,,UMLS_CUI:C0020542|SNOMEDCT_US_2016_03_01:155328008|SNOMEDCT_US_2016_03_01:70995007|MESH:D006976|ICD10CM:I27.2|NCI:C3120|SNOMEDCT_US_2016_03_01:266293003,,,disease_ontology,,DOID:6432,,,,,,,,,,,,,,,,,,,pulmonary hypertension,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200554,"[""OR2V2 gene""]",,"An olfactory receptor 2V2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R30] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2V2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R30] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200554,,,,,,,,,,,,,,,,285659,OR2V2,OR2V3,,,,,,,,,,OR2V2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200093,"[""CATSPER1 gene""]",,"Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400345,,,,,,,,"Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200093,,,,,,,,,,,,,,,,117144,CATSPER1,,,,,,,,,,,CATSPER1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200222,"[""KCNK12 gene""]",,"This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400359,,,,,,,,"This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200222,,,,,,,,,,,,,,,,56660,KCNK12,,,,,,,,,,,KCNK12 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100235,"[""Potassium voltage-gated channel subfamily KQT member 4""]",,"A voltage-gated potassium channel subunit KCNQ4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P56696] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300564,,,,,,,,"A voltage-gated potassium channel subunit KCNQ4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P56696] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100235,,,,https://pharos.nih.gov/idg/targets/P56696,,,,,,,,,,,,,KCNQ4,,,P56696,,,,,,,,Potassium voltage-gated channel subfamily KQT member 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004082,"[""HCC-827 cell""]",,Non-small cell lung adenocarcinoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0004078,,,,,,,,Non-small cell lung adenocarcinoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004082,,,,,,,BrendaTissueOBO,HCC827 cell,BTO:0004082,,,,,,,,,,,,,,,,,,,HCC-827 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004689,"[""external gill""]",,"External gills are the gills of an animal, most typically an amphibian, that are exposed to the environment, rather than set inside the pharynx and covered by gill slits, as they are in most fishes.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000518,,,,,,,,"External gills are the gills of an animal, most typically an amphibian, that are exposed to the environment, rather than set inside the pharynx and covered by gill slits, as they are in most fishes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004689,mgr,2010-05-14T10:12:08Z,,,,,BrendaTissueOBO,,BTO:0004689,,,,,,,,,,,,,,,,,,,external gill,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000184,"[""medullary thyroid carcinoma cell""]",,"A cell ot a type of thyroid gland carcinoma that contains amyloid deposits and parafollicular cells and secretes calcitonin. It occurs in both an autosomal dominant form as a component of multiple endocrine neoplasia, types II and III, and in a nonfamilial form.",false,,,http://purl.obolibrary.org/obo/BTO_0000191|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000196,,,,,,,,"A cell ot a type of thyroid gland carcinoma that contains amyloid deposits and parafollicular cells and secretes calcitonin. It occurs in both an autosomal dominant form as a component of multiple endocrine neoplasia, types II and III, and in a nonfamilial form.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000184,,,,,,,BrendaTissueOBO,"medullary carcinoma cell of thyroid gland|MTC cell|thyroid carcinoma cell, medullary",BTO:0000184,,,,,,,,,,,,,,,,,,,medullary thyroid carcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002420,"[""monocytic leukemia cell""]",,A cell of leukemia characterized by the proliferation of monocytes and monoblasts in the blood.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001271,,,,,,,,A cell of leukemia characterized by the proliferation of monocytes and monoblasts in the blood.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002420,,,,,,,BrendaTissueOBO,histiocytic leukemia cell|monoblastic leukaemia cell|monoblastic leukemia cell|histiocytic leukaemia cell,BTO:0002420,,,,,,,,,,,,,,,,,,,monocytic leukemia cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100098,"[""FMet-Leu-Phe receptor""]",,"An fMet-Leu-Phe receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21462] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300041,,,,,,,,"An fMet-Leu-Phe receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21462] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100098,,,,https://pharos.nih.gov/idg/targets/P21462,,,,,,,,,,,,,FPR1,,,P21462,,,,,,,,FMet-Leu-Phe receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9120,"[""amyloidosis""]",,An acquired metabolic disease that involves abnormal deposited of amyloid proteins in organs and/or tissues.,false,,,http://purl.obolibrary.org/obo/DOID_0060158,,,,,,,,An acquired metabolic disease that involves abnormal deposited of amyloid proteins in organs and/or tissues.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9120,,,,MESH:D000686|ICD10CM:E85.9|UMLS_CUI:C0002726|SNOMEDCT_US_2016_03_01:190931005|ICD9CM:277.30|ICD10CM:E85|ICD9CM:277.3|SNOMEDCT_US_2016_03_01:154769007|NCI:C2868|SNOMEDCT_US_2016_03_01:17602002,amyloid disease,,disease_ontology,,DOID:9120,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,amyloidosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2030,"[""anxiety disorder""]",,"A cognitive disorder that involves an excessive, irrational dread of everyday situations.",false,,,http://purl.obolibrary.org/obo/DOID_1561,,,,,,,,"A cognitive disorder that involves an excessive, irrational dread of everyday situations.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2030,,,DOID:12884,OMIM:607834|UMLS_CUI:C0003469|SNOMEDCT_US_2016_03_01:191703000|MESH:D001008|ICD10CM:F41.9|UMLS_CUI:C0154455|ICD9CM:300.09|SNOMEDCT_US_2016_03_01:65673007|SNOMEDCT_US_2016_03_01:197480006|SNOMEDCT_US_2016_03_01:192405006|NCI:C2878,anxiety|anxiety state,,disease_ontology,,DOID:2030,,,,,,,,,,,,,,,,,,,anxiety disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001561,"[""DAUDI cell""]",,Human Burkitt's lymphoma cell line; established from the Burkitt's lymphoma (left orbital biopsy) of a 16-year-old African boy in 1967; cells were described to be EBV-positive and to express mRNA for proto-oncogene bcl-2.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000889,,,,,,,,Human Burkitt's lymphoma cell line; established from the Burkitt's lymphoma (left orbital biopsy) of a 16-year-old African boy in 1967; cells were described to be EBV-positive and to express mRNA for proto-oncogene bcl-2.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001561,,,,,,,BrendaTissueOBO,,BTO:0001561,,,,,,,,,,,,,,,,,,,DAUDI cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001461,"[""whole plant""]",,The main part of a plant.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001481,,,,,,,,The main part of a plant.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001461,,,,,,,BrendaTissueOBO,Pflanzenkoerper,BTO:0001461,,,,,,,,,,,,,,,,,,,whole plant,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005681,"[""storage root""]",,"A modified root for storage of food or water, such as carrots and beets.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001188,,,,,,,,"A modified root for storage of food or water, such as carrots and beets.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005681,Marion,2014-09-10T14:00:43Z,,,,,BrendaTissueOBO,,BTO:0005681,,,,,,,,,,,,,,,,,,,storage root,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200104,"[""FXYD6 gene""]",,"This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes phosphohippolin, which likely affects the activity of Na,K-ATPase. Multiple alternatively spliced transcript variants encoding the same protein have been described. Related pseudogenes have been identified on chromosomes 10 and X. Read-through transcripts have been observed between this locus and the downstream sodium/potassium-transporting ATPase subunit gamma (FXYD2, GeneID 486) locus.[provided by RefSeq, Feb 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400349,,,,,,,,"This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes phosphohippolin, which likely affects the activity of Na,K-ATPase. Multiple alternatively spliced transcript variants encoding the same protein have been described. Related pseudogenes have been identified on chromosomes 10 and X. Read-through transcripts have been observed between this locus and the downstream sodium/potassium-transporting ATPase subunit gamma (FXYD2, GeneID 486) locus.[provided by RefSeq, Feb 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200104,,,,,,,,,,,,,,,,100533181|53826,FXYD6,,,,,,,,,,,FXYD6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_74,"[""hematopoietic system disease""]",,An immune system disease that has_material_basis_in hematopoietic cells.,false,,,http://purl.obolibrary.org/obo/DOID_7,,,,,,,,An immune system disease that has_material_basis_in hematopoietic cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:74,,,,MESH:D006402|SNOMEDCT_US_2016_03_01:34093004|SNOMEDCT_US_2016_03_01:267573000|SNOMEDCT_US_2016_03_01:154842002|ICD9CM:280-289.99|SNOMEDCT_US_2016_03_01:191124002|ICD9CM:289.9|UMLS_CUI:C0018939|SNOMEDCT_US_2016_03_01:267552000|ICD10CM:D75.9|SNOMEDCT_US_2016_03_01:191402006|SNOMEDCT_US_2016_03_01:154785002|SNOMEDCT_US_2016_03_01:191446003|NCI:C26323,Hematological disease|Blood dyscrasia NOS|Blood disease|disease of hematopoietic system|blood disorder|DISEASE OF THE BLOOD AND BLOOD-FORMING ORGANS,,disease_ontology,,DOID:74,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,hematopoietic system disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_746,"[""adenomatoid tumor""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2645,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:746,,,,NCI:C3762|SNOMEDCT_US_2016_03_01:2348006|MESH:D018254|ICD10CM:D19.9|SNOMEDCT_US_2016_03_01:41183007|UMLS_CUI:C0206675|SNOMEDCT_US_2016_03_01:189835008,adenomatoid tumor NOS (morphologic abnormality)|adenomatoid tumor (morphologic abnormality)|benign localized epithelial Mesothelioma,,disease_ontology,,DOID:746,,,,,,,,,,,,,,,,,,,adenomatoid tumor,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_749,"[""active peptic ulcer disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_750,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:749,,,,,,,disease_ontology,GI Bleeding,DOID:749,,,,,,,,,,,,,,,,,,,active peptic ulcer disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001853,"[""vascular endothelium""]",,The innermost lining of a blood vessel.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000393,,,,,,,,The innermost lining of a blood vessel.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001853,,,,,,,BrendaTissueOBO,,BTO:0001853,,,,,,,,,,,,,,,,,,,vascular endothelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3010,"[""lobular neoplasia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_8791,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3010,,,,UMLS_CUI:C0861352|NCI:C27939,lobular carcinoma in situ|Lobular Intraepithelial Neoplasia,,disease_ontology,,DOID:3010,,,,,,,,,,,,,,,,,,,lobular neoplasia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100267,"[""Melatonin receptor type 1a""]",,"A melatonin receptor type 1A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48039] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300065,,,,,,,,"A melatonin receptor type 1A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48039] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100267,,,,https://pharos.nih.gov/idg/targets/P48039,,,,,,,,,,,,,MTNR1A,,,P48039,,,,,,,,Melatonin receptor type 1a,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000006,"[""osteoblastoma cell""]",,A benign tumor cell of bone.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000372,,,,,,,,A benign tumor cell of bone.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000006,,,,,,,BrendaTissueOBO,,BTO:0000006,,,,,,,,,,,,,,,,,,,osteoblastoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10976,"[""membranous glomerulonephritis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2921,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10976,,,,NCI:C34645|ICD10CM:N03.2|EFO:0004254|UMLS_CUI:C0017665|SNOMEDCT_US_2016_03_01:197710000|SNOMEDCT_US_2016_03_01:77182004|MESH:D015433,membranous nephropathy,,disease_ontology,,DOID:10976,,,,,,,,,,,,,,,,,,,membranous glomerulonephritis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400094,"[""Beta adrenoceptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400022,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400094,,,,,,,,,,,,,,,,,,,,,,,,,,,,Beta adrenoceptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003946,"[""MMDD1 cell""]",,Mouse macula densa-derived cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002886,,,,,,,,Mouse macula densa-derived cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003946,,,,,,,BrendaTissueOBO,MMDD-1 cell,BTO:0003946,,,,,,,,,,,,,,,,,,,MMDD1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000267,"[""PHE617 in TRKC""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000267,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE617 in TRKC,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200365,"[""NIM1K gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400299,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200365,,,,,,,,,,,,,,,,167359,NIM1K,NIM1,,,,,,,,,,NIM1K gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4621,"[""holoprosencephaly""]",,A congenital nervous system abnormality characterized by failed or incomplete separation of the forebrain early in gestation; it is accompanied by a spectrum of characteristic craniofacial anomalies.,false,,,http://purl.obolibrary.org/obo/DOID_2490,,,,,,,,A congenital nervous system abnormality characterized by failed or incomplete separation of the forebrain early in gestation; it is accompanied by a spectrum of characteristic craniofacial anomalies.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4621,,,,MESH:D016142|ICD10CM:Q04.2|UMLS_CUI:C0079541|NCI:C74988|ORDO:2162|SNOMEDCT_US_2016_03_01:30915001|SNOMEDCT_US_2016_03_01:44519006,Holoprosencephaly sequence (disorder),,disease_ontology,,DOID:4621,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,holoprosencephaly,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300481,"[""Two pore calcium channel subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300333,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300481,,,,,,,,,,,,,,,,,,,,,,,,,,,,Two pore calcium channel subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100421,"[""Olfactory receptor 52h1""]",,"An olfactory receptor 52H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 52H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100421,,,,https://pharos.nih.gov/idg/targets/Q8NGJ2,,,,,,,,,,,,,OR52H1,,,Q8NGJ2,,,,,,,,Olfactory receptor 52h1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000066,"[""CAMKK2 kinase domain""]",,"Calcium/calmodulin-dependent protein kinase kinase 2, beta; CAMKK; CAMKK2; CAMKKB; KIAA0787; MGC15254",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Calcium/calmodulin-dependent protein kinase kinase 2, beta; CAMKK; CAMKK2; CAMKKB; KIAA0787; MGC15254",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000066,,,,,,,,,,,,,,,,,,,200069,,,,,,,,,CAMKK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000252,"[""PHE239 in CLK4""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000252,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE239 in CLK4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100128,"[""Ephrin type-a receptor 4""]",,"ephrin type-a receptor 4 (EPHA4)  with  no mutation  in a nonphosphorylated state|An ephrin type-A receptor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54764] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300153,,,,,,,,"ephrin type-a receptor 4 (EPHA4)  with  no mutation  in a nonphosphorylated state|An ephrin type-A receptor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54764] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100128,,,,https://pharos.nih.gov/idg/targets/P54764,,,,,,,,,,,,,EPHA4,HEK8|SEK|TYRO1,,P54764,,,,,,,,Ephrin type-a receptor 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100081,"[""Ceramide kinase""]",,"A ceramide kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TCT0] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300323,,,,,,,,"A ceramide kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TCT0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100081,,,,https://pharos.nih.gov/idg/targets/Q8TCT0,,,,,,,,,,,,,CERK,KIAA1646,,Q8TCT0,,,,,,,,Ceramide kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10126,"[""keratoconus""]",,"A corneal disease characterized by structural changes within the cornea causing it to thin and change, leading to a protruding conical shape.",false,,,http://purl.obolibrary.org/obo/DOID_10124,,,,,,,,"A corneal disease characterized by structural changes within the cornea causing it to thin and change, leading to a protruding conical shape.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10126,,,,MESH:D007640|ICD9CM:371.6|OMIM:608932|OMIM:609271|OMIM:148300|ICD10CM:H18.60|ICD9CM:371.60|OMIM:614628|NCI:C26806|SNOMEDCT_US_2016_03_01:155160005|SNOMEDCT_US_2016_03_01:193843006|ICD10CM:H18.6|OMIM:614629|SNOMEDCT_US_2016_03_01:267733008|ORDO:156071|OMIM:614622|OMIM:608586|OMIM:614623|UMLS_CUI:C0022578|SNOMEDCT_US_2016_03_01:193846003|SNOMEDCT_US_2016_03_01:65636009,conical cornea,,disease_ontology,,DOID:10126,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,keratoconus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10127,"[""cerebral artery occlusion""]",,,false,,,http://purl.obolibrary.org/obo/DOID_6713,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10127,,,,ICD9CM:434.9|UMLS_CUI:C0028790|SNOMEDCT_US_2016_03_01:155403004|SNOMEDCT_US_2016_03_01:155400001|SNOMEDCT_US_2016_03_01:286956007|SNOMEDCT_US_2016_03_01:20059004|ICD9CM:434|SNOMEDCT_US_2016_03_01:266255008|SNOMEDCT_US_2016_03_01:195188006,,,disease_ontology,,DOID:10127,,,,,,,,,,,,,,,,,,,cerebral artery occlusion,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10123,"[""pigmentation disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_37,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10123,,,,ICD9CM:709.09|UMLS_CUI:C0375489,,,disease_ontology,,DOID:10123,,,,,,,,,,,,,,,,,,,pigmentation disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10124,"[""corneal disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5614,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10124,,,DOID:2284,MESH:D003316|ICD10CM:H18.9|SNOMEDCT_US_2016_03_01:193856004|NCI:C26731|SNOMEDCT_US_2016_03_01:155160005|SNOMEDCT_US_2016_03_01:193794007|UMLS_CUI:C0010034|ICD9CM:371.9|SNOMEDCT_US_2016_03_01:15250008|SNOMEDCT_US_2016_03_01:267733008,,,disease_ontology,,DOID:10124,,,,,,,,,,,,,,,,,,,corneal disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100535,"[""Tribbles homolog 1""]",,"A tribbles homolog 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RU8] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300237,,,,,,,,"A tribbles homolog 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RU8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100535,,,,https://pharos.nih.gov/idg/targets/Q96RU8,,,,,,,,,,,,,TRIB1,C8FW|GIG2|TRB1,,Q96RU8,,,,,,,,Tribbles homolog 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200158,"[""KCNJ2 gene""]",,"Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400429,,,,,,,,"Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200158,,,,,,,,,,,,,,,,3759,KCNJ2,IRK1,,,,,,,,,,KCNJ2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200464,"[""SBK1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400222,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200464,,,,,,,,,,,,,,,,388228,SBK1,,,,,,,,,,,SBK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000392,"[""THR753 in EPHA5""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000392,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR753 in EPHA5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200649,"[""OR5W2 gene""]",,"An olfactory receptor 5W2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH69] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5W2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH69] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200649,,,,,,,,,,,,,,,,390148,OR5W2,OR5W2P|OR5W3P,,,,,,,,,,OR5W2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000139,"[""body wall""]",,"The portion of an animal body that consists of ectoderm and mesoderm, forms the external body surface, and encloses the body cavity.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The portion of an animal body that consists of ectoderm and mesoderm, forms the external body surface, and encloses the body cavity.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000139,,,,,,,BrendaTissueOBO,Koerperwand,BTO:0000139,,,,,,,,,,,,,,,,,,,body wall,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005397,"[""SH-EP cell""]",,The SHEP human neuroblastoma cell line was subcloned from SK-N-SH.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The SHEP human neuroblastoma cell line was subcloned from SK-N-SH.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005397,XPMUser,2012-09-03T09:54:09Z,,,,,BrendaTissueOBO,SHEP cell,BTO:0005397,,,,,,,,,,,,,,,,,,,SH-EP cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9246,"[""cerebral amyloid angiopathy""]",,"An amyloidosis where amyloid protein progressively deposits in cerebral blood vessel walls with subsequent degenerative vascular changes that usually result in spontaneous cerebral hemorrhage, ischemic lesions and progressive dementia.",false,,,http://purl.obolibrary.org/obo/DOID_9120,,,,,,,,"An amyloidosis where amyloid protein progressively deposits in cerebral blood vessel walls with subsequent degenerative vascular changes that usually result in spontaneous cerebral hemorrhage, ischemic lesions and progressive dementia.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9246,,,,OMIM:105150|SNOMEDCT_US_2016_03_01:56453003|OMIM:176500|UMLS_CUI:C0268394|OMIM:117300|MESH:D028243|ORDO:85458|OMIM:605714,Hereditary cerebral haemorrhage with amyloidosis - Dutch type (disorder)|dutch hereditary cerebral amyloid angiopathy,,disease_ontology,,DOID:9246,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,cerebral amyloid angiopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000448,"[""TXK kinase domain""]",,TXK tyrosine kinase; BTKL; MGC22473; PSCTK5; PTK4; RLK; TKL; TXK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,TXK tyrosine kinase; BTKL; MGC22473; PSCTK5; PTK4; RLK; TKL; TXK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000448,,,,,,,,,,,,,,,,,,,200449,,,,,,,,,TXK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000908,"[""myrosin cell""]",,"Cell containing glucosinolates (mustard oil glucosides) and myrosinases, enzymes hydrolyzing the glucosinolates. Occur in eleven dicotyledon families, the two largest of which are the Brassicaceae and Euphorbiaceae.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Cell containing glucosinolates (mustard oil glucosides) and myrosinases, enzymes hydrolyzing the glucosinolates. Occur in eleven dicotyledon families, the two largest of which are the Brassicaceae and Euphorbiaceae.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000908,,,,,,,BrendaTissueOBO,,BTO:0000908,,,,,,,,,,,,,,,,,,,myrosin cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001510,"[""rectal cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001510,,,,,,,BrendaTissueOBO,,BTO:0001510,,,,,,,,,,,,,,,,,,,rectal cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8354,"[""complement component 3 deficiency""]",,Xref MGI.,false,,,http://purl.obolibrary.org/obo/DOID_626,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8354,,,,OMIM:613779|NCI:C9468|UMLS_CUI:C1332655|ORDO:280133,C3 deficiency,,disease_ontology,,DOID:8354,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,complement component 3 deficiency,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_7465,"[""chronic NK-cell lymphocytosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2916,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:7465,,,,NCI:C39591|UMLS_CUI:C1512709,NK-cell large granular Lymphocyte Lymphocytosis,,disease_ontology,,DOID:7465,,,,,,,,,,,,,,,,,,,chronic NK-cell lymphocytosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000142,"[""brain""]",,"1: The portion of the vertebrate central nervous system that constitutes the organ of thought and neural coordination, includes all the higher nervous centers receiving stimuli from the sense organs and interpreting and correlating them to formulate the motor impulses, is made up of neurons and supporting and nutritive structures, is enclosed within the skull, and is continuous with the spinal cord through the foramen magnum. Also named encephalon. 2: A nervous center in invertebrates comparable in position and function to the vertebrate brain.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,,"1: The portion of the vertebrate central nervous system that constitutes the organ of thought and neural coordination, includes all the higher nervous centers receiving stimuli from the sense organs and interpreting and correlating them to formulate the motor impulses, is made up of neurons and supporting and nutritive structures, is enclosed within the skull, and is continuous with the spinal cord through the foramen magnum. Also named encephalon. 2: A nervous center in invertebrates comparable in position and function to the vertebrate brain.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000142,,,,,,,BrendaTissueOBO,encephalon,BTO:0000142,,,,,,,,,,,,,,,,,,,brain,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200536,"[""OR2L5 gene""]",,"An olfactory receptor 2L5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG80] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2L5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG80] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200536,,,,,,,,,,,,,,,,81466,OR2L5,OR2L11,,,,,,,,,,OR2L5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300499,"[""Beta-2/CHRNB2 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300499,,,,,,,,,,,,,,,,,,,,,,,,,,,,Beta-2/CHRNB2 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_30623,"[""oxalate(2-)""]","MUBZPKHOEPUJKR-UHFFFAOYSA-L|C2O4|InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2|[O-]C(=O)C([O-])=O|oxalate|ox|OXALATE ION|ethanedioic acid, ion(2-)","
A dicarboxylic acid dianion obtained by deprotonation of both carboxy groups of oxalic acid.
",false,,,http://purl.obolibrary.org/obo/CHEBI_22563,,,,,,,ChemIDplus:338-70-5|ChEBI:C00209|Gmelin:2207|Reaxys:1905970|PDBeChem:OXL|Beilstein:1905970|UM-BBD:c0017,"
A dicarboxylic acid dianion obtained by deprotonation of both carboxy groups of oxalic acid.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:14702|CHEBI:25729|CHEBI:44820,,ethanedioate,,chebi_ontology,"MUBZPKHOEPUJKR-UHFFFAOYSA-L|C2O4|InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2|[O-]C(=O)C([O-])=O|oxalate|ox|OXALATE ION|ethanedioic acid, ion(2-)",,,CHEBI:30623,,,,,,,,,,,,,,,,,,,,,,,CHEBI:30623,,,,,oxalate(2-),,CHEBI:30623,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80306,"[""Kisspeptin-13""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16092,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80306,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80306,,,,,Kisspeptin-13,,CHEBI:80306,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001770,"[""ciliary epithelium""]",,The ciliary epithelium produces the aqueous humor of the eye.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000416,,,,,,,,The ciliary epithelium produces the aqueous humor of the eye.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001770,,,,,,,BrendaTissueOBO,ciliary body epithelium,BTO:0001770,,,,,,,,,,,,,,,,,,,ciliary epithelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002738,"[""cement gland""]",,"Typical barnacles, common name of the sedentary crustacean marine animals constituting the subclass Cirripedia, attach to the substrate by means of an exceedingly adhesive cement, produced by a cement gland, and secrete a shell, or carapace, of calcareous (limestone) plates, around themselves.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000765,,,,,,,,"Typical barnacles, common name of the sedentary crustacean marine animals constituting the subclass Cirripedia, attach to the substrate by means of an exceedingly adhesive cement, produced by a cement gland, and secrete a shell, or carapace, of calcareous (limestone) plates, around themselves.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002738,,,,,,,BrendaTissueOBO,cementary gland,BTO:0002738,,,,,,,,,,,,,,,,,,,cement gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000411,"[""SLK kinase domain""]",,STE20-like serine/threonine-protein kinase; CTCL tumor antigen se20-9; bA16H23.1; KIAA0204; LOSK; MGC133067; se20-9; SLK; STK2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,STE20-like serine/threonine-protein kinase; CTCL tumor antigen se20-9; bA16H23.1; KIAA0204; LOSK; MGC133067; se20-9; SLK; STK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000411,,,,,,,,,,,,,,,,,,,200412,,,,,,,,,SLK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5533,"[""endometrial squamous cell carcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1749|http://purl.obolibrary.org/obo/DOID_2871,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5533,,,,UMLS_CUI:C1333396|NCI:C8719,squamous cell carcinoma of Endometrium,,disease_ontology,,DOID:5533,,,,,,,,,,,,,,,,,,,endometrial squamous cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2691,"[""myoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_461,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2691,,,,SNOMEDCT_US_2016_03_01:66357004|MESH:D009214|ICD10CM:D21|SNOMEDCT_US_2016_03_01:92237006|UMLS_CUI:C0027086|NCI:C4882,benign neoplasm of the Muscle,,disease_ontology,,DOID:2691,,,,,,,,,,,,,,,,,,,myoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100080,"[""C-x-c chemokine receptor type 6""]",,"A C-X-C chemokine receptor type 6 that is encoded in the genome of human. [PRO:CNx, Reactome:REACT_14906] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300097,,,,,,,,"A C-X-C chemokine receptor type 6 that is encoded in the genome of human. [PRO:CNx, Reactome:REACT_14906] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100080,,,,https://pharos.nih.gov/idg/targets/O00574,,,,,,,,,,,,,CXCR6,BONZO|STRL33|TYMSTR,,O00574,,,,,,,,C-x-c chemokine receptor type 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8432,"[""polycythemia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4961,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8432,,,,SNOMEDCT_US_2016_03_01:44865000|UMLS_CUI:C0032461|SNOMEDCT_US_2016_03_01:127062003|NCI:C26863|ICD10CM:D75.1|SNOMEDCT_US_2016_03_01:109992005|SNOMEDCT_US_2016_03_01:165401000|MESH:D011086,Erythrocythemia,,disease_ontology,,DOID:8432,,,,,,,,,,,,,,,,,,,polycythemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_17996,"[""Chloride""]",Chloor|CHLORIDE ION|Chloride ion|Cl(-)|Chlore|Chloride(1-)|Cl-|Molecular chlorine|[Cl-]|Cl|Bertholite|InChI=1S/ClH/h1H/p-1|Dichlorine|Chlor|Chlorine anion|Diatomic chlorine|Chlorine gas|VEXZGXHMUGYJMC-UHFFFAOYSA-M|Cl2,"
A halide anion formed when chlorine picks up an electron to form an an anion.
",false,,,http://purl.obolibrary.org/obo/CHEBI_22563,,,,,,,KEGG COMPOUND:C00698|PDBeChem:CL|UM-BBD:c0884|CiteXplore:16078037|CiteXplore:17729441|NIST Chemistry WebBook:16887-00-6|MetaCyc:CPD-4521|KEGG COMPOUND:C00115|CiteXplore:24246267|Wikipedia:Chlorine|Gmelin:14910|Beilstein:3587171|KEGG COMPOUND:16887-00-6|CiteXplore:17562499|CiteXplore:7539703|CiteXplore:15300163|HMDB:HMDB00492|CiteXplore:17539703|ChemIDplus:16887-00-6,"
A halide anion formed when chlorine picks up an electron to form an an anion.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:3616|CHEBI:13291|CHEBI:13970|CHEBI:48804|CHEBI:3731,,chloride(1-)|chloride|Chloride,,chebi_ontology,Chloor|CHLORIDE ION|Chloride ion|Cl(-)|Chlore|Chloride(1-)|Cl-|Molecular chlorine|[Cl-]|Cl|Bertholite|InChI=1S/ClH/h1H/p-1|Dichlorine|Chlor|Chlorine anion|Diatomic chlorine|Chlorine gas|VEXZGXHMUGYJMC-UHFFFAOYSA-M|Cl2,,,CHEBI:17996,,,,,,,,,,,,,,,,,,,,,,,CHEBI:17996,,,,,chloride|Chloride,,CHEBI:17996,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000080,"[""CDK7 kinase domain""]",,Cyclin-dependent kinase 7; cell division protein kinase 7; CAK1; CDK7; CDKN7; MO15; p39MO15; STK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Cyclin-dependent kinase 7; cell division protein kinase 7; CAK1; CDK7; CDKN7; MO15; p39MO15; STK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000080,,,,,,,,,,,,,,,,,,,200080,,,,,,,,,CDK7 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200354,"[""OR14I1 gene""]",,"An olfactory receptor 14I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6ND48] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 14I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6ND48] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200354,,,,,,,,,,,,,,,,401994,OR14I1,OR5BU1|OR5BU1P,,,,,,,,,,OR14I1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300193,"[""MOS family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300193,,,,,,,,,,,,,,,,,,,,,,,,,,,,MOS family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100051,"[""Cholecystokinin receptor type a""]",,"A cholecystokinin receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32238] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300030,,,,,,,,"A cholecystokinin receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32238] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100051,,,,https://pharos.nih.gov/idg/targets/P32238,,,,,,,,,,,,,CCKAR,CCKRA,,P32238,,,,,,,,Cholecystokinin receptor type a,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300226,"[""SRPK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300111,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300226,,,,,,,,,,,,,,,,,,,,,,,,,,,,SRPK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060020,"[""reticular dysgenesis""]",,"A severe combined immunodeficiency that is the most severe form of SCID and has material basis in mutations in the gene encoding mitochondrial adenylate kinase 2. It is characterized by congenital agranulocytosis, lymphopenia, and lymphoid and thymic hypoplasia with absent cellular and humoral immunity functions.",false,,,http://purl.obolibrary.org/obo/DOID_627,,,,,,,,"A severe combined immunodeficiency that is the most severe form of SCID and has material basis in mutations in the gene encoding mitochondrial adenylate kinase 2. It is characterized by congenital agranulocytosis, lymphopenia, and lymphoid and thymic hypoplasia with absent cellular and humoral immunity functions.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060020,,,DOID:1226,UMLS_CUI:C0272167|NCI:C27070|SNOMEDCT_US_2016_03_01:111584000|OMIM:267500|MESH:C538361,De Vaal disease,,disease_ontology,aleukocytosis,DOID:0060020,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,reticular dysgenesis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060021,"[""DNA ligase IV deficiency""]",,"A combined T cell and B cell immunodeficiency that has material basis in a mutation in the LIG4 gene, a DNA ligase, encoding a protein essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). Patients present with immunodeficiency and developmental and growth delay.",false,,,http://purl.obolibrary.org/obo/DOID_628,,,,,,,,"A combined T cell and B cell immunodeficiency that has material basis in a mutation in the LIG4 gene, a DNA ligase, encoding a protein essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). Patients present with immunodeficiency and developmental and growth delay.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060021,,,,OMIM:606593,LIG4 Syndrome,,disease_ontology,,DOID:0060021,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,DNA ligase IV deficiency,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060028,"[""Good syndrome""]",,An agammaglobulinemia that is a condition where there is co-occurrence of deficient cell-mediated immunity and benign thymoma.,false,,,http://purl.obolibrary.org/obo/DOID_2583,,,,,,,,An agammaglobulinemia that is a condition where there is co-occurrence of deficient cell-mediated immunity and benign thymoma.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060028,,,,,thymoma with hypogammaglobulinemia,,disease_ontology,,DOID:0060028,,,,,,,,,,,,,,,,,,,Good syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200138,"[""GRID2 gene""]",,"The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans. [provided by RefSeq, Apr 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_01400415,,,,,,,,"The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans. [provided by RefSeq, Apr 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200138,,,,,,,,,,,,,,,,2895,GRID2,GLURD2,,,,,,,,,,GRID2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200295,"[""MAP4K3 gene""]",,"This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400287,,,,,,,,"This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200295,,,,,,,,,,,,,,,,8491,MAP4K3,RAB8IPL1,,,,,,,,,,MAP4K3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000166,"[""MET395 in PAK4""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000166,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET395 in PAK4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100175,"[""Homeodomain-interacting protein kinase 4""]",,"A homeodomain-interacting protein kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NE63] |homeodomain-interacting protein kinase 4 (HIPK4)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300273,,,,,,,,"A homeodomain-interacting protein kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NE63] |homeodomain-interacting protein kinase 4 (HIPK4)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100175,,,,https://pharos.nih.gov/idg/targets/Q8NE63,,,,,,,,,,,,,HIPK4,,,Q8NE63,,,,,,,,Homeodomain-interacting protein kinase 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400540,"[""Kv2.2/KCNB2 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400442,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400540,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv2.2/KCNB2 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491029,"[""Choline/ethanolamine kinase family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400324,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491029,,,,,,,,,,,,,,,,,,,,,,,,,,,,Choline/ethanolamine kinase family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2861,"[""congenital nonspherocytic hemolytic anemia""]",,"Xref MGI.
OMIM mapping by NeuroDevNet. [LS].",false,,,http://purl.obolibrary.org/obo/DOID_589,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2861,,,,SNOMEDCT_US_2016_03_01:300389006|SNOMEDCT_US_2016_03_01:82775009|OMIM:206300|OMIM:300908|OMIM:613470|UMLS_CUI:C0002882|SNOMEDCT_US_2016_03_01:301317008|OMIM:206400|ORDO:712|MESH:D000746,HNSHA|hereditary nonspherocytic hemolytic anemia,,disease_ontology,,DOID:2861,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping by NeuroDevNet. [LS].",,congenital nonspherocytic hemolytic anemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10348,"[""blepharophimosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_530,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10348,,,,MESH:D016569|ICD10CM:H02.52|ICD9CM:374.46|UMLS_CUI:C0005744,,,disease_ontology,,DOID:10348,,,,,,,,,,,,,,,,,,,blepharophimosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200053,"[""CCR1 gene""]",,"A C-C chemokine receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32246] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400095,,,,,,,,"A C-C chemokine receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32246] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200053,,,,,,,,,,,,,,,,1230,CCR1,CMKBR1|CMKR1|SCYAR1,,,,,,,,,,CCR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3463,"[""breast disease""]",,A thoracic disease that is located_in the breast.,false,,,http://purl.obolibrary.org/obo/DOID_0060118,,,,,,,,A thoracic disease that is located_in the breast.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3463,,,,SNOMEDCT_US_2016_03_01:266647006|SNOMEDCT_US_2016_03_01:79604008|ICD9CM:610-612.99|SNOMEDCT_US_2016_03_01:155962003|UMLS_CUI:C0006145|SNOMEDCT_US_2016_03_01:155946009|MESH:D001941|ICD10CM:N60-N65|SNOMEDCT_US_2016_03_01:155966000|SNOMEDCT_US_2016_03_01:198129001|SNOMEDCT_US_2016_03_01:198566004|ICD10CM:N64.9|NCI:C26709|ICD9CM:611.9,,,disease_ontology,,DOID:3463,,,,,,,,,,,,,,,,,,,breast disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217550,"[""HNF4G gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00217467,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217550,,,,,,,,,,,,,,,,3174,HNF4G,NR2A2,,,,,,,,,,HNF4G gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300090,"[""UPF0359 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300090,,,,,,,,,,,,,,,,,,,,,,,,,,,,UPF0359 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200575,"[""OR4C15 gene""]",,"An olfactory receptor 4C15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGM1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4C15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGM1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200575,,,,,,,,,,,,,,,,81309,OR4C15,,,,,,,,,,,OR4C15 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200728,"[""P2RY4 gene""]",,"A P2Y purinoceptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51582] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400100,,,,,,,,"A P2Y purinoceptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51582] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200728,,,,,,,,,,,,,,,,5030,P2RY4,NRU,,,,,,,,,,P2RY4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100381,"[""Phosphatidylinositol 4-kinase type 2-alpha""]",,"A phosphatidylinositol 4-kinase type 2-alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BTU6] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391005,,,,,,,,"A phosphatidylinositol 4-kinase type 2-alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BTU6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100381,,,,https://pharos.nih.gov/idg/targets/Q9BTU6,,,,,,,,,,,,,PI4K2A,,,Q9BTU6,,,,,,,,Phosphatidylinositol 4-kinase type 2-alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200363,"[""OR2AG2 gene""]",,"An olfactory receptor 2AG2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NM03] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2AG2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NM03] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200363,,,,,,,,,,,,,,,,338755,OR2AG2,OR2AG2P,,,,,,,,,,OR2AG2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200456,"[""ROCK1 gene""]",,"This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400313,,,,,,,,"This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200456,,,,,,,,,,,,,,,,6093,ROCK1,,,,,,,,,,,ROCK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8437,"[""intestinal obstruction""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5295,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8437,,,,UMLS_CUI:C0021843|SNOMEDCT_US_2016_03_01:197074008|ICD10CM:K56.60|SNOMEDCT_US_2016_03_01:155777003|SNOMEDCT_US_2016_03_01:81060008|NCI:C9175|SNOMEDCT_US_2016_03_01:197073002|ICD10CM:K56.69|SNOMEDCT_US_2016_03_01:155771002|SNOMEDCT_US_2016_03_01:266523009|SNOMEDCT_US_2016_03_01:197080000|SNOMEDCT_US_2016_03_01:197072007|ICD9CM:560.9|MESH:D007415,,,disease_ontology,,DOID:8437,,,,,,,,,,,,,,,,,,,intestinal obstruction,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491045,"[""PANK3 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491028,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491045,,,,,,,,,,,,,,,,,PANK3,,,,,,,,,,,PANK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100624,"[""Sedoheptulokinase""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100624,,,,,,,,,,,,,,,,,SHPK,,,Q9UHJ6,,,,,,,,Sedoheptulokinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300493,"[""Alpha-4/CHRNA4 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300493,,,,,,,,,,,,,,,,,,,,,,,,,,,,Alpha-4/CHRNA4 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12568,"[""dyscalculia""]",,"A learning disability involving a math disability can cause such difficulties as learning math concepts (such as quantity, place value, and time), difficulty memorizing math facts, difficulty organizing numbers, and understanding how problems are organized on the page.",false,,,http://purl.obolibrary.org/obo/DOID_8927,,,,,,,,"A learning disability involving a math disability can cause such difficulties as learning math concepts (such as quantity, place value, and time), difficulty memorizing math facts, difficulty organizing numbers, and understanding how problems are organized on the page.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12568,,,,,disorder of arithmetical skills|Mathematics disorder,,disease_ontology,,DOID:12568,,,,,,,,,,,,,,,,,,,dyscalculia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200086,"[""CNGA2 gene""]",,"The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400403,,,,,,,,"The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200086,,,,,,,,,,,,,,,,1260,CNGA2,CNCA|CNCA1|CNCG2,,,,,,,,,,CNGA2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200212,"[""GPR84 gene""]",,"A G-protein coupled receptor 84 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NQS5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400058,,,,,,,,"A G-protein coupled receptor 84 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NQS5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200212,,,,,,,,,,,,,,,,53831,GPR84,EX33,,,,,,,,,,GPR84 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000472,"[""FM3A cell""]",,Mouse mammary carcinoma cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0004086|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Mouse mammary carcinoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000472,,,,,,,BrendaTissueOBO,,BTO:0000472,,,,,,,,,,,,,,,,,,,FM3A cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001605,"[""reticulum trabeculare""]",,"A trabeculum of loose fibers found at the iridocorneal angle between the anterior chamber of the eye and the venous sinus of the sclera; the aqueous humor filters through the spaces between the fibers into the sinus and passes into the bloodstream. The reticulum is divided into a corneoscleral part and a uveal part;  An area of tissue in the eye located around the base of the cornea, near the ciliary body, and is responsible for draining the aqueous humor from the eye via the anterior chamber. The tissue is spongy and lined by trabeculocytes; it allows fluid to drain into a set of tubes called Schlemm's canal flowing into the blood system.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A trabeculum of loose fibers found at the iridocorneal angle between the anterior chamber of the eye and the venous sinus of the sclera; the aqueous humor filters through the spaces between the fibers into the sinus and passes into the bloodstream. The reticulum is divided into a corneoscleral part and a uveal part;  An area of tissue in the eye located around the base of the cornea, near the ciliary body, and is responsible for draining the aqueous humor from the eye via the anterior chamber. The tissue is spongy and lined by trabeculocytes; it allows fluid to drain into a set of tubes called Schlemm's canal flowing into the blood system.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001605,,,,,,,BrendaTissueOBO,pectinate ligament|ligamentum pectinatum anguli iridocornealis|trabecular meshwork|pectinate ligament of iris|Hueck's ligament,BTO:0001605,,,,,,,,,,,,,,,,,,,reticulum trabeculare,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200555,"[""OR2W1 gene""]",,"An olfactory receptor 2W1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y3N9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2W1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y3N9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200555,,,,,,,,,,,,,,,,26692,OR2W1,,,,,,,,,,,OR2W1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300282,"[""P70 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300178,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300282,,,,,,,,,,,,,,,,,,,,,,,,,,,,P70 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300585,"[""TRPM3 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300483,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300585,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPM3 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200773,"[""SSTR4 gene""]",,"A somatostatin receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P31391] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A somatostatin receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P31391] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200773,,,,,,,,,,,,,,,,6754,SSTR4,,,,,,,,,,,SSTR4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000053,"[""BMX kinase domain""]",,BMX non-receptor tyrosine kinase; BMX; ETK; Etk/BMX; PSCTK2; PSCTK3,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,BMX non-receptor tyrosine kinase; BMX; ETK; Etk/BMX; PSCTK2; PSCTK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000053,,,,,,,,,,,,,,,,,,,200053,,,,,,,,,BMX kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100548,"[""Olfactory receptor 2T4""]",,"An olfactory receptor 2T4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH00] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2T4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH00] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100548,,,,https://pharos.nih.gov/idg/targets/Q8NH00,,,,,,,,,,,,,OR2T4,,,Q8NH00,,,,,,,,Olfactory receptor 2T4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3744,"[""cervical squamous cell carcinoma""]",,A cervix carcinoma that has_material_basis_in squamous cells of the cervix.,false,,,http://purl.obolibrary.org/obo/DOID_2893,,,,,,,,A cervix carcinoma that has_material_basis_in squamous cells of the cervix.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3744,,,,NCI:C4028|SNOMEDCT_US_2016_03_01:254886006|UMLS_CUI:C0279671,squamous cell carcinoma of the Cervix Uteri|squamous cell carcinoma of cervix (disorder),,disease_ontology,,DOID:3744,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,cervical squamous cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300270,"[""EEF2K subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300123,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300270,,,,,,,,,,,,,,,,,,,,,,,,,,,,EEF2K subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002414,"[""PG-CL3 cell""]",,Cloned PG cell subline.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Cloned PG cell subline.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002414,,,,,,,BrendaTissueOBO,PGCL3 cell,BTO:0002414,,,,,,,,,,,,,,,,,,,PG-CL3 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003151,"[""HPAEC cell""]",,Human pulmonary artery endothelial cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003150,,,,,,,,Human pulmonary artery endothelial cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003151,,,,,,,BrendaTissueOBO,human pulmonary artery endothelial cell,BTO:0003151,,,,,,,,,,,,,,,,,,,HPAEC cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000019,"[""CX3CL1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000019,,,,,,,,,,,,,,,,,,,,,,,,,,,,CX3CL1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100084,"[""Choline kinase alpha""]",,"A choline kinase alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35790] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391029,,,,,,,,"A choline kinase alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35790] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100084,,,,https://pharos.nih.gov/idg/targets/P35790,,,,,,,,,,,,,CHKA,CHK|CKI,,P35790,,,,,,,,Choline kinase alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100137,"[""Adhesion G protein-coupled receptor A1""]",,"A G-protein coupled receptor 123 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86SQ6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,"A G-protein coupled receptor 123 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86SQ6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100137,,,,https://pharos.nih.gov/idg/targets/Q86SQ6,,,,,,,,,,,,,GPR123,ADGRA1|KIAA1828,,Q86SQ6,,,,,,,,Adhesion G protein-coupled receptor A1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200197,"[""GPR42 gene""]",,"A G-protein coupled receptor 42 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15529] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 42 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15529] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200197,,,,,,,,,,,,,,,,2866,GPR42,GPR42P,,,,,,,,,,GPR42 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100610,"[""Putative nucleoside diphosphate kinase""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100610,,,,,,,,,,,,,,,,,NME2P1,,,O60361,,,,,,,,Putative nucleoside diphosphate kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400578,"[""TRPC3 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400482,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400578,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPC3 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100285,"[""Ryanodine receptor 2""]",,"A ryanodine receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92736] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300461,,,,,,,,"A ryanodine receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92736] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100285,,,,https://pharos.nih.gov/idg/targets/Q92736,,,,,,,,,,,,,RYR2,,,Q92736,,,,,,,,Ryanodine receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000469,"[""flower""]",,The reproductive structure of the anthophyta or angiosperms.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The reproductive structure of the anthophyta or angiosperms.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000469,,,,,,,BrendaTissueOBO,,BTO:0000469,,,,,,,,,,,,,,,,,,,flower,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003975,"[""cingulate cortex""]",,"A part of the brain situated in the medial aspect of the cortex. It is extended from the corpus callosum below to the cingulate sulcus above, at least anteriorly.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A part of the brain situated in the medial aspect of the cortex. It is extended from the corpus callosum below to the cingulate sulcus above, at least anteriorly.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003975,,,,,,,BrendaTissueOBO,,BTO:0003975,,,,,,,,,,,,,,,,,,,cingulate cortex,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000020,"[""ILE332 in KPCI""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30009,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000020,,,,,,,,,,,,,,,,,,,,,,,,,,,,ILE332 in KPCI,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100280,"[""Mitogen-activated protein kinase kinase kinase 14""]",,"mitogen-activated protein kinase kinase kinase 14 (MAP3K14)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase kinase kinase 14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99558] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300185,,,,,,,,"mitogen-activated protein kinase kinase kinase 14 (MAP3K14)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase kinase kinase 14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99558] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100280,,,,https://pharos.nih.gov/idg/targets/Q99558,,,,,,,,,,,,,MAP3K14,NIK,,Q99558,,,,,,,,Mitogen-activated protein kinase kinase kinase 14,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004496,"[""preosteoclast""]",,Precursors of an osteoclast.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Precursors of an osteoclast.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004496,Marion,2010-02-04T05:56:25Z,,,,,BrendaTissueOBO,,BTO:0004496,,,,,,,,,,,,,,,,,,,preosteoclast,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300466,"[""SCN2B family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300370,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300466,,,,,,,,,,,,,,,,,,,,,,,,,,,,SCN2B family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400273,"[""HIPK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400150,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400273,,,,,,,,,,,,,,,,,,,,,,,,,,,,HIPK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200670,"[""OR6T1 gene""]",,"An olfactory receptor 6T1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6T1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200670,,,,,,,,,,,,,,,,219874,OR6T1,,,,,,,,,,,OR6T1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200267,"[""P2RX4 gene""]",,"The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400364,,,,,,,,"The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200267,,,,,,,,,,,,,,,,5025,P2RX4,,,,,,,,,,,P2RX4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001612,"[""colorectal adenoma cell""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0001615|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000178,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001612,,,,,,,BrendaTissueOBO,,BTO:0001612,,,,,,,,,,,,,,,,,,,colorectal adenoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000722,"[""leg muscle""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001103,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000722,,,,,,,BrendaTissueOBO,,BTO:0000722,,,,,,,,,,,,,,,,,,,leg muscle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000130,"[""neutrophil""]",,A granulocyte that is the chief phagocytic white blood cell of the blood.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000539|http://purl.obolibrary.org/obo/BTO_0001044,,,,,,,,A granulocyte that is the chief phagocytic white blood cell of the blood.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000130,,,,,,,BrendaTissueOBO,neutrophilic leucocyte|neutrophilic leukocyte|neutrophil granulocyte,BTO:0000130,,,,,,,,,,,,,,,,,,,neutrophil,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300064,"[""Motilin receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300064,,,,,,,,,,,,,,,,,,,,,,,,,,,,Motilin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100061,"[""Voltage-dependent calcium channel gamma-7 subunit""]",,"A voltage-dependent calcium channel gamma-7 subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62955] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300336,,,,,,,,"A voltage-dependent calcium channel gamma-7 subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62955] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100061,,,,https://pharos.nih.gov/idg/targets/P62955,,,,,,,,,,,,,CACNG7,,,P62955,,,,,,,,Voltage-dependent calcium channel gamma-7 subunit,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00000016,"[""nucleotide GPCR ligand""]",,A GPCR ligand that is classified as nucleotide in CHEBI.,false,,,http://purl.obolibrary.org/obo/CHEBI_36976|http://www.drugtargetontology.org/dto/DTO_00000001,,,,,,,,A GPCR ligand that is classified as nucleotide in CHEBI.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00000016,,,,,,,,,,,,,,,,,,,,,,,,,,,Asiyah Yu Lin,nucleotide GPCR ligand,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400265,"[""GEK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400145,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400265,,,,,,,,,,,,,,,,,,,,,,,,,,,,GEK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400313,"[""ROCK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400145,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400313,,,,,,,,,,,,,,,,,,,,,,,,,,,,ROCK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300474,"[""Nav1.7/SCN9A subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300369,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300474,,,,,,,,,,,,,,,,,,,,,,,,,,,,Nav1.7/SCN9A subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1749,"[""squamous cell carcinoma""]",,A carcinoma that derives_from squamous epithelial cells.,false,,,http://purl.obolibrary.org/obo/DOID_305,,,,,,,,A carcinoma that derives_from squamous epithelial cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1749,,,DOID:5512,SNOMEDCT_US_2016_03_01:28899001|NCI:C2929|SNOMEDCT_US_2016_03_01:154605007|SNOMEDCT_US_2016_03_01:189566008|SNOMEDCT_US_2016_03_01:402815007|UMLS_CUI:C0007137|EFO:0000707|MESH:D018307|UMLS_CUI:C0751688|MESH:D002294,squamous carcinoma|squamous cell Epithelioma|squamous cell carcinoma (disorder)|squamous cell carcinoma NOS (morphologic abnormality)|malignant squamous cell tumor|squamous cell carcinoma (morphologic abnormality)|squamous cell cancer|epidermoid carcinoma,,disease_ontology,,DOID:1749,,,,,,,,,,,,,,,,,,,squamous cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100242,"[""Lysophosphatidic acid receptor 5""]",,"A lysophosphatidic acid receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H1C0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302007,,,,,,,,"A lysophosphatidic acid receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H1C0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100242,,,,https://pharos.nih.gov/idg/targets/Q9H1C0,,,,,,,,,,,,,LPAR5,GPR92|GPR93,,Q9H1C0,,,,,,,,Lysophosphatidic acid receptor 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000060,"[""LEU159 in PDPK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000060,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU159 in PDPK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000816,"[""breast cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000816,,,,,,,BrendaTissueOBO,,BTO:0000816,,,,,,,,,,,,,,,,,,,breast cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200013,"[""CHRNA9 gene""]",,"This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. [provided by RefSeq, Feb 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400497,,,,,,,,"This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. [provided by RefSeq, Feb 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200013,,,,,,,,,,,,,,,,55584,CHRNA9,NACHRA9,,,,,,,,,,CHRNA9 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200075,"[""CXCR1 gene""]",,"A C-X-C chemokine receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25024] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400031,,,,,,,,"A C-X-C chemokine receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25024] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200075,,,,,,,,,,,,,,,,3577,CXCR1,CMKAR1|IL8RA,,,,,,,,,,CXCR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200271,"[""TACR2 gene""]",,"A substance-K receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21452] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400066,,,,,,,,"A substance-K receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21452] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200271,,,,,,,,,,,,,,,,6865,TACR2,NK2R|NKNAR|TAC2R,,,,,,,,,,TACR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100123,"[""Gamma-aminobutyric acid receptor subunit rho-2""]",,"A gamma-aminobutyric acid receptor subunit rho-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P28476] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300522,,,,,,,,"A gamma-aminobutyric acid receptor subunit rho-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P28476] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100123,,,,https://pharos.nih.gov/idg/targets/P28476,,,,,,,,,,,,,GABRR2,,,P28476,,,,,,,,Gamma-aminobutyric acid receptor subunit rho-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200787,"[""TAS2R41 gene""]",,"A taste receptor type 2 member 41 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59536] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400014,,,,,,,,"A taste receptor type 2 member 41 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59536] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200787,,,,,,,,,,,,,,,,259287,TAS2R41,,,,,,,,,,,TAS2R41 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100031,"[""Alpha-2B adrenergic receptor""]",,"An alpha-2B adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P18089] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300093,,,,,,,,"An alpha-2B adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P18089] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100031,,,,https://pharos.nih.gov/idg/targets/P18089,,,,,,,,,,,,,ADRA2B,ADRA2L1|ADRA2RL1,,P18089,,,,,,,,Alpha-2B adrenergic receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000200,"[""JAK1(Kin.Dom.1) kinase domain""]",,Janus kinase 1; JAK1; JAK1~b; JAK1A; JAK1B; JAK1-pseudokinase; JTK3,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Janus kinase 1; JAK1; JAK1~b; JAK1A; JAK1B; JAK1-pseudokinase; JTK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000200,,,,,,,,,,,,,,,,,,,"200203, 200205",,,,,,,,,JAK1(Kin.Dom.1) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100392,"[""Olfactory receptor 51e1""]",,"An olfactory receptor 51E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TCB6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 51E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TCB6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100392,,,,https://pharos.nih.gov/idg/targets/Q8TCB6,,,,,,,,,,,,,OR51E1,GPR164|OR51E1P|OR52A3P|POGR|PSGR2,,Q8TCB6,,,,,,,,Olfactory receptor 51e1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80258,"[""Neuropeptide B-29""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16034,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80258,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80258,,,,,Neuropeptide B-29,,CHEBI:80258,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000401,"[""RSK4(Kin.Dom.2-C-terminal) kinase domain""]",,Ribosomal protein S6 kinase alpha 6; S6K-alpha-6; p90-RSK 6; pp90RSK4,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Ribosomal protein S6 kinase alpha 6; S6K-alpha-6; p90-RSK 6; pp90RSK4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000401,,,,,,,,,,,,,,,,,,,"200398, 200405",,,,,,,,,RSK4(Kin.Dom.2-C-terminal) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100220,"[""Potassium channel subfamily K member 9""]",,"A potassium channel subfamily K member 9 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NPC2] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300359,,,,,,,,"A potassium channel subfamily K member 9 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NPC2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100220,,,,https://pharos.nih.gov/idg/targets/Q9NPC2,,,,,,,,,,,,,KCNK9,TASK3,,Q9NPC2,,,,,,,,Potassium channel subfamily K member 9,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200041,"[""BLK gene""]",,"This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400132,,,,,,,,"This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200041,,,,,,,,,,,,,,,,640,BLK,,,,,,,,,,,BLK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100303,"[""Amiloride-sensitive sodium channel subunit alpha""]",,"An amiloride-sensitive sodium channel subunit alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P37088] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300477,,,,,,,,"An amiloride-sensitive sodium channel subunit alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P37088] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100303,,,,https://pharos.nih.gov/idg/targets/P37088,,,,,,,,,,,,,SCNN1A,SCNN1,,P37088,,,,,,,,Amiloride-sensitive sodium channel subunit alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9406,"[""hypopituitarism""]",,A pituitary gland disease characterized by the decreased secretion of one or more of the eight hormones normally produced by the pituitary gland.,false,,,http://purl.obolibrary.org/obo/DOID_53,,,,,,,,A pituitary gland disease characterized by the decreased secretion of one or more of the eight hormones normally produced by the pituitary gland.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9406,,,,ICD10CM:E23.0|OMIM:262600|MESH:D007018|OMIM:613038|SNOMEDCT_US_2016_03_01:237681002|SNOMEDCT_US_2016_03_01:190469009|OMIM:613986|ORDO:95494|SNOMEDCT_US_2016_03_01:154703006|NCI:C62591|UMLS_CUI:C0020635|SNOMEDCT_US_2016_03_01:74728003|SNOMEDCT_US_2016_03_01:267482009|OMIM:262700|OMIM:221750,pituitary hormone deficiency|Pituitary insufficiency,,disease_ontology,Pituitary hypofunction,DOID:9406,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,hypopituitarism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200375,"[""OR2T35 gene""]",,"An olfactory receptor 2T35 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2T35 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200375,,,,,,,,,,,,,,,,403244,OR2T35,,,,,,,,,,,OR2T35 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300030,"[""Cholecystokinin receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300030,,,,,,,,,,,,,,,,,,,,,,,,,,,,Cholecystokinin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_26,"[""pancreas disease""]",,An endocrine system disease that is located_in the pancreas.,false,,,http://purl.obolibrary.org/obo/DOID_28,,,,,,,,An endocrine system disease that is located_in the pancreas.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:26,,,,UMLS_CUI:C0029771|ICD10CM:K86.8|SNOMEDCT_US_2016_03_01:197566002|ICD9CM:577.8,,,disease_ontology,,DOID:26,,,,,,,,,,,,,,,,,,,pancreas disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_263,"[""kidney cancer""]",,A urinary system cancer that is located_in the kidney.,false,,,http://purl.obolibrary.org/obo/DOID_3996|http://purl.obolibrary.org/obo/DOID_557,,,,,,,,A urinary system cancer that is located_in the kidney.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:263,,,DOID:3676|DOID:11834,SNOMEDCT_US_2016_03_01:188249002|SNOMEDCT_US_2016_03_01:93849006|NCI:C120456|SNOMEDCT_US_2016_03_01:363518003|ICD10CM:C64|ICD9CM:189.0|SNOMEDCT_US_2016_03_01:126880001|NCI:C3150|MESH:D007680|UMLS_CUI:C0022665|UMLS_CUI:C0740457|UMLS_CUI:C0494158|SNOMEDCT_US_2016_03_01:154542008|NCI:C7548,renal cancer|malignant tumour of kidney|malignant neoplasm of kidney except pelvis,,disease_ontology,,DOID:263,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,kidney cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200046,"[""CACNA1I gene""]",,"This gene encodes the pore-forming alpha subunit of a voltage gated calcium channel. The encoded protein is a member of a subfamily of calcium channels referred to as is a low voltage-activated, T-type, calcium channel. The channel encoded by this protein is characterized by a slower activation and inactivation compared to other T-type calcium channels. This protein may be involved in calcium signaling in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400389,,,,,,,,"This gene encodes the pore-forming alpha subunit of a voltage gated calcium channel. The encoded protein is a member of a subfamily of calcium channels referred to as is a low voltage-activated, T-type, calcium channel. The channel encoded by this protein is characterized by a slower activation and inactivation compared to other T-type calcium channels. This protein may be involved in calcium signaling in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200046,,,,,,,,,,,,,,,,8911,CACNA1I,KIAA1120,,,,,,,,,,CACNA1I gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100466,"[""Uncharacterized serine/threonine-protein kinase sbk3""]",,A uncharacterized serine/threonine-protein kinase SgK110 that is encoded in the genome of human. |uncharacterized serine/threonine-protein kinase sbk3 (SgK110)  with  no mutation  in a nonphosphorylated state,false,,,http://www.drugtargetontology.org/dto/DTO_03300222,,,,,,,,A uncharacterized serine/threonine-protein kinase SgK110 that is encoded in the genome of human. |uncharacterized serine/threonine-protein kinase sbk3 (SgK110)  with  no mutation  in a nonphosphorylated state,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100466,,,,https://pharos.nih.gov/idg/targets/P0C264,,,,,,,,,,,,,SBK3,SGK110,,P0C264,,,,,,,,Uncharacterized serine/threonine-protein kinase sbk3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000433,"[""TGFBR2 kinase domain""]",,"Transforming growth factor, beta receptor II (70/80kDa); AAT3; FAA3; LDS1B; LDS2B; MFS2; RIIC; TAAD2; TGFbeta-RII; TGFBR2; TGFR-2",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Transforming growth factor, beta receptor II (70/80kDa); AAT3; FAA3; LDS1B; LDS2B; MFS2; RIIC; TAAD2; TGFbeta-RII; TGFBR2; TGFR-2",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000433,,,,,,,,,,,,,,,,,,,200434,,,,,,,,,TGFBR2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4325,"[""Ebola hemorrhagic fever""]",,"A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Zaire ebolavirus, has_material_basis_in Sudan ebolavirus, has_material_basis_in Cote d'Ivoire ebolavirus, or has_material_basis_in Bundibugyo ebolavirus, which are transmitted_by contact with the body fluids of an infected animal or person, transmitted_by contaminated fomites, or transmitted_by infected medical equipment. The infection has_symptom fever, has_symptom headache, has_symptom joint pain, has_symptom muscle aches, has_symptom sore throat, has_symptom weakness, has_symptom diarrhea, has_symptom vomiting, has_symptom stomach pain, has_symptom rash, has_symptom red eyes, has_symptom hiccups, and has_symptom internal and external bleeding.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Zaire ebolavirus, has_material_basis_in Sudan ebolavirus, has_material_basis_in Cote d'Ivoire ebolavirus, or has_material_basis_in Bundibugyo ebolavirus, which are transmitted_by contact with the body fluids of an infected animal or person, transmitted_by contaminated fomites, or transmitted_by infected medical equipment. The infection has_symptom fever, has_symptom headache, has_symptom joint pain, has_symptom muscle aches, has_symptom sore throat, has_symptom weakness, has_symptom diarrhea, has_symptom vomiting, has_symptom stomach pain, has_symptom rash, has_symptom red eyes, has_symptom hiccups, and has_symptom internal and external bleeding.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4325,,,,ICD10CM:A98.4|MESH:D019142|UMLS_CUI:C0282687|SNOMEDCT_US_2016_03_01:186746000|NCI:C36171|SNOMEDCT_US_2016_03_01:123323003|SNOMEDCT_US_2016_03_01:37109004,Ebola virus disease,,disease_ontology,,DOID:4325,http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,Ebola hemorrhagic fever,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300387,"[""CACNA1G subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300333,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300387,,,,,,,,,,,,,,,,,,,,,,,,,,,,CACNA1G subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200232,"[""CAMKK1 gene""]",,"The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400275,,,,,,,,"The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200232,,,,,,,,,,,,,,,,84254,CAMKK1,CAMKKA,,,,,,,,,,CAMKK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100226,"[""Potassium channel subfamily K member 17""]",,"A potassium channel subfamily K member 17 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96T54] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300359,,,,,,,,"A potassium channel subfamily K member 17 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96T54] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100226,,,,https://pharos.nih.gov/idg/targets/Q96T54,,,,,,,,,,,,,KCNK17,TALK2|TASK4,,Q96T54,,,,,,,,Potassium channel subfamily K member 17,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000991,"[""pancreatic islet""]",,"Irregular microscopic structures scattered throughout the pancreas and comprising its endocrine part (the endocrine pancreas). In humans, they are composed of at least four types of cells: the alpha cells, which secrete glucagon; the beta cells, which are the most abundant and secrete insulin; the delta cells, which secrete somatostatin; and the PP cells, which secrete pancreatic polypeptide. Degeneration of the beta cells, whose secretion (insulin) is important in carbohydrate metabolism, is the major cause of type I diabetes mellitus.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Irregular microscopic structures scattered throughout the pancreas and comprising its endocrine part (the endocrine pancreas). In humans, they are composed of at least four types of cells: the alpha cells, which secrete glucagon; the beta cells, which are the most abundant and secrete insulin; the delta cells, which secrete somatostatin; and the PP cells, which secrete pancreatic polypeptide. Degeneration of the beta cells, whose secretion (insulin) is important in carbohydrate metabolism, is the major cause of type I diabetes mellitus.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000991,,,,,,,BrendaTissueOBO,island of pancreas|islet of Langerhans|island of Langerhans,BTO:0000991,,,,,,,,,,,,,,,,,,,pancreatic islet,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100110,"[""Deoxyguanosine kinase, mitochondrial""]",,"A deoxyguanosine kinase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16854] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391008,,,,,,,,"A deoxyguanosine kinase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16854] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100110,,,,https://pharos.nih.gov/idg/targets/Q16854,,,,,,,,,,,,,DGUOK,DGK,,Q16854,,,,,,,,"Deoxyguanosine kinase, mitochondrial",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000901,"[""myocardium""]",,"The middle and thickest layer of the heart wall, composed of cardiac muscle.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000199,,,,,,,,"The middle and thickest layer of the heart wall, composed of cardiac muscle.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000901,,,,,,,BrendaTissueOBO,,BTO:0000901,,,,,,,,,,,,,,,,,,,myocardium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001077,"[""AtT-20 cell""]",,Mouse pituitary tumor cell line. Morphology: small rounded cells.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000756,,,,,,,,Mouse pituitary tumor cell line. Morphology: small rounded cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001077,,,,,,,BrendaTissueOBO,AtT20 cell|AtT 20 cell,BTO:0001077,,,,,,,,,,,,,,,,,,,AtT-20 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100495,"[""Serine/threonine-protein kinase 10""]",,"A serine/threonine-protein kinase 10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O94804] |serine/threonine-protein kinase 10 (LOK)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300315,,,,,,,,"A serine/threonine-protein kinase 10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O94804] |serine/threonine-protein kinase 10 (LOK)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100495,,,,https://pharos.nih.gov/idg/targets/O94804,,,,,,,,,,,,,STK10,LOK,,O94804,,,,,,,,Serine/threonine-protein kinase 10,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002018,"[""corpus cavernosum clitoridis""]",,"A column of erectile tissue on either side (right and left), the two fusing to form the body of the clitoris.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A column of erectile tissue on either side (right and left), the two fusing to form the body of the clitoris.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002018,,,,,,,BrendaTissueOBO,cavernous body of clitoris|clitoral corpus cavernosum|corpus cavernosum,BTO:0002018,,,,,,,,,,,,,,,,,,,corpus cavernosum clitoridis,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000994,"[""RBL-1 cell""]",,Rat basophilic leukemia; this rat basophilic leukemia (RBL) cell line was established from chlorethylamine-treated rats.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001018,,,,,,,,Rat basophilic leukemia; this rat basophilic leukemia (RBL) cell line was established from chlorethylamine-treated rats.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000994,,,,,,,BrendaTissueOBO,,BTO:0000994,,,,,,,,,,,,,,,,,,,RBL-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8574,"[""lichen disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_37,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8574,,,,SNOMEDCT_US_2016_03_01:88996004|SNOMEDCT_US_2016_03_01:156376003|ICD9CM:697.9|SNOMEDCT_US_2016_03_01:201010002|UMLS_CUI:C0023643|SNOMEDCT_US_2016_03_01:156379005|ICD9CM:697|ICD10CM:L28.0|SNOMEDCT_US_2016_03_01:200998004,,,disease_ontology,,DOID:8574,,,,,,,,,,,,,,,,,,,lichen disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000215,"[""5-oxo-ODE""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000215,,,,,,,,,,,,,,,,,,,,,,,,,,,,5-oxo-ODE,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050657,"[""Bannayan-Riley-Ruvalcaba syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050657,,,,OMIM:153480,RUVALCABA-MYHRE-SMITH SYNDROME|BANNAYAN-ZONANA SYNDROME|RILEY-SMITH SYNDROME,,disease_ontology,,DOID:0050657,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Bannayan-Riley-Ruvalcaba syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050650,"[""familial atrial fibrillation""]",,An atrial fibrillation that has_material_basis_in autosomal dominant inheritance of the familial atrial fibrillation (ATFB) genes.,false,,,http://purl.obolibrary.org/obo/DOID_0060224,,,,,,,,An atrial fibrillation that has_material_basis_in autosomal dominant inheritance of the familial atrial fibrillation (ATFB) genes.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050650,,,,OMIM:613055|OMIM:612240|OMIM:615377|OMIM:614049|OMIM:608583|OMIM:613980|OMIM:611493|OMIM:615770|OMIM:607554|OMIM:614050|OMIM:608988|ORDO:334|OMIM:612201|OMIM:614022|OMIM:611494|OMIM:615378,ATFB,,disease_ontology,,DOID:0050650,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,familial atrial fibrillation,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005401,"[""junctional zone""]",,The murine placenta consists of two main fetally derived compartments: the labyrinthine zone and the junctional zone.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The murine placenta consists of two main fetally derived compartments: the labyrinthine zone and the junctional zone.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005401,XPMUser,2012-09-04T11:39:36Z,,,,,BrendaTissueOBO,,BTO:0005401,,,,,,,,,,,,,,,,,,,junctional zone,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050773,"[""paraganglioma""]",,Xref MGI.,false,,,http://purl.obolibrary.org/obo/DOID_169,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050773,lschriml,2013-02-21T11:51:57Z,,OMIM:601650|OMIM:168000|SNOMEDCT_US_2016_03_01:803009|SNOMEDCT_US_2016_03_01:72787006|NCI:C3308|OMIM:605373|OMIM:115310|SNOMEDCT_US_2016_03_01:302833002|UMLS_CUI:C0030421|SNOMEDCT_US_2016_03_01:253029009|SNOMEDCT_US_2016_03_01:189743009|OMIM:614165|MESH:D010235|SNOMEDCT_US_2016_03_01:127027008,chemodectoma,,disease_ontology,,DOID:0050773,,,,,,,,,,,,,,,,,Xref MGI.,,paraganglioma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050777,"[""Joubert syndrome""]",,"A ciliopathy that is characterized by congenital malformation of the brainstem and agenesis or hypoplasia of the cerebellar vermis leading to an abnormal respiratory pattern, nystagmus, hypotonia, ataxia, and delay in achieving motor milestones.",false,,,http://purl.obolibrary.org/obo/DOID_0060340,,,,,,,,"A ciliopathy that is characterized by congenital malformation of the brainstem and agenesis or hypoplasia of the cerebellar vermis leading to an abnormal respiratory pattern, nystagmus, hypotonia, ataxia, and delay in achieving motor milestones.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050777,lschriml,2013-04-04T11:25:32Z,,OMIM:608629|OMIM:614615|ORDO:475|OMIM:614970|OMIM:616654|OMIM:610188|OMIM:614464|OMIM:614465|OMIM:615665|OMIM:615636|OMIM:609583|OMIM:612285|OMIM:611560|OMIM:300804|OMIM:614173|OMIM:610688|OMIM:614424|OMIM:612291|OMIM:614815|OMIM:608091|OMIM:213300,JBTS,,disease_ontology,,DOID:0050777,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,Joubert syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050776,"[""non-syndromic X-linked intellectual disability""]",,A non-syndromic intellectual disability characterized by a X-linked inheritance pattern.,false,,,http://purl.obolibrary.org/obo/DOID_0050889,,,,,,,,A non-syndromic intellectual disability characterized by a X-linked inheritance pattern.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050776,lschriml,2013-02-21T12:06:40Z,,OMIM:300852|OMIM:300210|OMIM:300046|OMIM:300803|OMIM:300372|OMIM:300428|OMIM:300436|OMIM:300577|OMIM:300505|OMIM:300355|OMIM:300851|OMIM:300912|OMIM:300433|OMIM:300498|OMIM:300716|OMIM:300919|OMIM:300143|ORDO:777|OMIM:300659|OMIM:300062|OMIM:300504|OMIM:300923|OMIM:300844|OMIM:300558|OMIM:300802|OMIM:300518|OMIM:300850|OMIM:300271|OMIM:300848|OMIM:300114|OMIM:309530|OMIM:300324|OMIM:300047|OMIM:300387|OMIM:300115|OMIM:300454|OMIM:300849|OMIM:309549,non-specific X-linked mental retardation,,disease_ontology,,DOID:0050776,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,Xref MGI.,,non-syndromic X-linked intellectual disability,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050770,"[""polycystic liver disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050770,lschriml,2013-02-21T11:36:13Z,,OMIM:174050,,,disease_ontology,,DOID:0050770,,,,,,,,,,,,,,,,,,,polycystic liver disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050771,"[""phaeochromocytoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060084,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050771,lschriml,2013-02-21T11:40:58Z,,OMIM:171300,,,disease_ontology,,DOID:0050771,,,,,,,,,,,,,,,,,,,phaeochromocytoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050778,"[""Meckel syndrome""]",,"A ciliopathy that is characterized by renal cystic dysplasia, occipital encephalocele, polydactyly (post axial), hepatic developmental defects, and pulmonary hypoplasia.",false,,,http://purl.obolibrary.org/obo/DOID_0060340,,,,,,,,"A ciliopathy that is characterized by renal cystic dysplasia, occipital encephalocele, polydactyly (post axial), hepatic developmental defects, and pulmonary hypoplasia.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050778,lschriml,2013-04-04T11:28:16Z,,OMIM:611134|OMIM:613885|OMIM:614175|ICD9CM:753.10|OMIM:615397|OMIM:607361|SNOMEDCT_US_2016_03_01:204966004|SNOMEDCT_US_2016_03_01:236440007|SNOMEDCT_US_2016_03_01:204954005|OMIM:612284|OMIM:249000|OMIM:267010|ICD9CM:753.1|UMLS_CUI:C0311245|OMIM:614209|SNOMEDCT_US_2016_03_01:82525005|OMIM:611561|ORDO:564|OMIM:603194,Meckel-Gruber syndrome,,disease_ontology,,DOID:0050778,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,Meckel syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002436,"[""myenteric plexus""]",,That part of the enteric plexus within the tunica muscularis.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,That part of the enteric plexus within the tunica muscularis.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002436,,,,,,,BrendaTissueOBO,plexus myentericus|Auerbach's plexus,BTO:0002436,,,,,,,,,,,,,,,,,,,myenteric plexus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050686,"[""organ system cancer""]",,A cancer that is classified based on the organ it starts in.,false,,,http://purl.obolibrary.org/obo/DOID_162,,,,,,,,A cancer that is classified based on the organ it starts in.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050686,snadendla,2011-06-13T03:28:33Z,,MESH:D009371,,,disease_ontology,,DOID:0050686,,,,,,,,,,,,,,,,,,,organ system cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050689,"[""brachydactyly-syndactyly syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050739,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050689,snadendla,2011-06-17T03:55:47Z,,OMIM:610713,,,disease_ontology,,DOID:0050689,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,brachydactyly-syndactyly syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050687,"[""cell type cancer""]",,A cancer that is classified by the type of cell from which it is derived.,false,,,http://purl.obolibrary.org/obo/DOID_162,,,,,,,,A cancer that is classified by the type of cell from which it is derived.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050687,snadendla,2011-06-13T03:28:50Z,,,,,disease_ontology,,DOID:0050687,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,cell type cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050685,"[""small cell carcinoma""]",,A carcinoma that is an undifferentiated neoplasm composed of primitive-appearing cells.,false,,,http://purl.obolibrary.org/obo/DOID_305,,,,,,,,A carcinoma that is an undifferentiated neoplasm composed of primitive-appearing cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050685,snadendla,2011-06-13T01:25:14Z,DOID:7137,SNOMEDCT_US_2016_03_01:5958006|NCI:C4099|UMLS_CUI:C0334239|SNOMEDCT_US_2016_03_01:189557009,"Small cell carcinoma, intermediate cell (morphologic abnormality)|intermediate cell small cell carcinoma|Small cell carcinoma - intermediate cell",,disease_ontology,,DOID:0050685,,,,,,,,,,,,,,,,,,,small cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2773,"[""contact dermatitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2723,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2773,,,,ICD10CM:L25.9|NCI:C26743|SNOMEDCT_US_2016_03_01:156348006|SNOMEDCT_US_2016_03_01:156338009|MESH:D003877|SNOMEDCT_US_2016_03_01:267842005|SNOMEDCT_US_2016_03_01:40275004|UMLS_CUI:C0011616|ICD10CM:L25|SNOMEDCT_US_2016_03_01:200889001|SNOMEDCT_US_2016_03_01:267846008|SNOMEDCT_US_2016_03_01:200883000|SNOMEDCT_US_2016_03_01:200780008,"Contact eczema|Contact dermatitis NOS (disorder)|Contact dermatitis/eczema|Contact dermatitis NOS|dermatitis venenata|Dermatitis, venenata NOS|Contact dermatitis (disorder)",,disease_ontology,,DOID:2773,,,,,,,,,,,,,,,,,,,contact dermatitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000439,"[""TNK1 kinase domain""]",,Non-receptor tyrosine-protein kinase TNK1; MGC46193; TNK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Non-receptor tyrosine-protein kinase TNK1; MGC46193; TNK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000439,,,,,,,,,,,,,,,,,,,200440,,,,,,,,,TNK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200552,"[""OR2T8 gene""]",,"An olfactory receptor 2T8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NH00] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2T8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NH00] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200552,,,,,,,,,,,,,,,,343172,OR2T8,OR2T8P,,,,,,,,,,OR2T8 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300444,"[""D (Shal) subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300444,,,,,,,,,,,,,,,,,,,,,,,,,,,,D (Shal) subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200492,"[""OR1J1 gene""]",,"An olfactory receptor 1J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200492,,,,,,,,,,,,,,,,347168,OR1J1,,,,,,,,,,,OR1J1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300205,"[""PHK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300205,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391010,"[""Phosphoinositide 3-kinase (PI3K) family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300323,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391010,,,,,,,,,,,,,,,,,,,,,,,,,,,,Phosphoinositide 3-kinase (PI3K) family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100526,"[""Olfactory receptor 2g6""]",,"An olfactory receptor 2G6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5TZ20] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2G6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5TZ20] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100526,,,,https://pharos.nih.gov/idg/targets/Q5TZ20,,,,,,,,,,,,,OR2G6,,,Q5TZ20,,,,,,,,Olfactory receptor 2g6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200434,"[""PLK5 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400308,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200434,,,,,,,,,,,,,,,,126520,PLK5,PLK5P,,,,,,,,,,PLK5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100441,"[""Tp53-regulating kinase""]",,"A TP53-regulating kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96S44] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300213,,,,,,,,"A TP53-regulating kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96S44] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100441,,,,https://pharos.nih.gov/idg/targets/Q96S44,,,,,,,,,,,,,TP53RK,C20orf64|PRPK,,Q96S44,,,,,,,,Tp53-regulating kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3652,"[""Leigh disease""]",,"A mitochondrial metabolism disease characterized by progressive loss of mental and movement abilities. Symptoms usually begin between ages of three months and two years and include loss of appetite, vomiting, irritability and seizure activity.",false,,,http://purl.obolibrary.org/obo/DOID_700,,,,,,,,"A mitochondrial metabolism disease characterized by progressive loss of mental and movement abilities. Symptoms usually begin between ages of three months and two years and include loss of appetite, vomiting, irritability and seizure activity.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3652,,,,MESH:D007888|UMLS_CUI:C0023264|ORDO:506|ICD10CM:G31.82|OMIM:256000|SNOMEDCT_US_2016_03_01:29570005|OMIM:220111|NCI:C84814,juvenile subacute necrotizing encephalomyelopathy|Infantile necrotizing encephalomyelopathy|Leigh syndrome,,disease_ontology,subacute necrotizing encephalomyelopathy,DOID:3652,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,Leigh disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300024,"[""Apelin receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300024,,,,,,,,,,,,,,,,,,,,,,,,,,,,Apelin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200591,"[""AK8 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200591,,,,,,,,,,,,,,,,,,,,,,,,,,,,AK8 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000123,"[""EGFR(G719S) kinase domain""]",,"Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000123,,,,,,,,,,,,,,,,,,,200125,,,,,,,,,EGFR(G719S) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200341,"[""TTYH3 gene""]",,"This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400373,,,,,,,,"This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200341,,,,,,,,,,,,,,,,80727,TTYH3,KIAA1691,,,,,,,,,,TTYH3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200763,"[""S1PR1 gene""]",,"A sphingosine 1-phosphate receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21453] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A sphingosine 1-phosphate receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21453] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200763,,,,,,,,,,,,,,,,1901,S1PR1,CHEDG1|EDG1,,,,,,,,,,S1PR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491049,"[""PFKFB3 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400325,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491049,,,,,,,,,,,,,,,,,PFKFB3,,,,,,,,,,,PFKFB3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000794,"[""pancreatic cancer cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000183,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000794,,,,,,,BrendaTissueOBO,,BTO:0000794,,,,,,,,,,,,,,,,,,,pancreatic cancer cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400379,"[""Acid-sensing ion channel 4 (ASIC4) subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400330,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400379,,,,,,,,,,,,,,,,,,,,,,,,,,,,Acid-sensing ion channel 4 (ASIC4) subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200435,"[""PKMYT1 gene""]",,"This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400212,,,,,,,,"This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200435,,,,,,,,,,,,,,,,9088,PKMYT1,MYT1,,,,,,,,,,PKMYT1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100556,"[""Serine/threonine-protein kinase ulk2""]",,"serine/threonine-protein kinase ulk2 (ULK2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase ULK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IYT8] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300228,,,,,,,,"serine/threonine-protein kinase ulk2 (ULK2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase ULK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IYT8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100556,,,,https://pharos.nih.gov/idg/targets/Q8IYT8,,,,,,,,,,,,,ULK2,KIAA0623,,Q8IYT8,,,,,,,,Serine/threonine-protein kinase ulk2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100502,"[""Serine/threonine-protein kinase 35""]",,"A serine/threonine-protein kinase 35 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TDR2] |serine/threonine-protein kinase 35 (STK35)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300202,,,,,,,,"A serine/threonine-protein kinase 35 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TDR2] |serine/threonine-protein kinase 35 (STK35)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100502,,,,https://pharos.nih.gov/idg/targets/Q8TDR2,,,,,,,,,,,,,STK35,CLIK1|PDIK1|STK35L1,,Q8TDR2,,,,,,,,Serine/threonine-protein kinase 35,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100104,"[""Serine/threonine-protein kinase dclk3""]",,"A serine/threonine-protein kinase DCLK3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9C098] |serine/threonine-protein kinase dclk3 (DCAMKL3)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300147,,,,,,,,"A serine/threonine-protein kinase DCLK3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9C098] |serine/threonine-protein kinase dclk3 (DCAMKL3)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100104,,,,https://pharos.nih.gov/idg/targets/Q9C098,,,,,,,,,,,,,DCLK3,DCAMKL3|DCDC3C|KIAA1765,,Q9C098,,,,,,,,Serine/threonine-protein kinase dclk3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005576,"[""inguinal canal""]",,A passage about one and one half inches (4 cm) long that lies parallel to and a half inch above the inguinal ligament. In the male it is the passage through which the testis descends into the scrotum and in which the spermatic cord lies - called also spermatic canal. In the female the passage is accommodating the round ligament.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A passage about one and one half inches (4 cm) long that lies parallel to and a half inch above the inguinal ligament. In the male it is the passage through which the testis descends into the scrotum and in which the spermatic cord lies - called also spermatic canal. In the female the passage is accommodating the round ligament.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005576,Marion,2014-03-02T20:47:38Z,,,,,BrendaTissueOBO,,BTO:0005576,,,,,,,,,,,,,,,,,,,inguinal canal,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200677,"[""OR7A17 gene""]",,"An olfactory receptor 7A17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14581] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 7A17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14581] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200677,,,,,,,,,,,,,,,,26333,OR7A17,,,,,,,,,,,OR7A17 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002664,"[""HTAU cell""]",,Immortilized embryonic brain cortex cell line overexpressing the human tau protein.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002659,,,,,,,,Immortilized embryonic brain cortex cell line overexpressing the human tau protein.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002664,,,,,,,BrendaTissueOBO,,BTO:0002664,,,,,,,,,,,,,,,,,,,HTAU cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001918,"[""LIM1863 cell""]",,Colon carcinoma cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0000797|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Colon carcinoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001918,,,,,,,BrendaTissueOBO,LIM 1863 cell,BTO:0001918,,,,,,,,,,,,,,,,,,,LIM1863 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217475,"[""Nerve growth factor ib-like receptors gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00200002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217475,,,,,,,,,,,,,,,,,,,,,,,,,,,,Nerve growth factor ib-like receptors gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100281,"[""Neuropeptide y receptor type 1""]",,"A neuropeptide Y receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25929] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300071,,,,,,,,"A neuropeptide Y receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25929] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100281,,,,https://pharos.nih.gov/idg/targets/P25929,,,,,,,,,,,,,NPY1R,NPYR|NPYY1,,P25929,,,,,,,,Neuropeptide y receptor type 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000060,"[""CAMK1 kinase domain""]",,Calcium/calmodulin-dependent protein kinase I; CAMK1; CaMK1a; CAMKI; MGC120317; MGC120318,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Calcium/calmodulin-dependent protein kinase I; CAMK1; CaMK1a; CAMKI; MGC120317; MGC120318,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000060,,,,,,,,,,,,,,,,,,,200060,,,,,,,,,CAMK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13976,"[""peptic esophagitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_750|http://purl.obolibrary.org/obo/DOID_11963,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13976,,,,SNOMEDCT_US_2016_03_01:155673008|SNOMEDCT_US_2016_03_01:266498005|SNOMEDCT_US_2016_03_01:196600005|SNOMEDCT_US_2016_03_01:57643001|UMLS_CUI:C0014869|MESH:D004942|ICD9CM:530.11|SNOMEDCT_US_2016_03_01:54856001,reflux esophagitis|Reflux oesophagitis|Peptic reflux disease|Peptic esophagitis,,disease_ontology,,DOID:13976,,,,,,,,,,,,,,,,,,,peptic esophagitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200186,"[""GPR25 gene""]",,"A G-protein coupled receptor 25 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00155] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400023,,,,,,,,"A G-protein coupled receptor 25 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00155] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200186,,,,,,,,,,,,,,,,2848,GPR25,,,,,,,,,,,GPR25 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300144,"[""CSK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300144,,,,,,,,,,,,,,,,,,,,,,,,,,,,CSK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8692,"[""myeloid leukemia""]",,A leukemia that is located_in myeloid tissue.,false,,,http://purl.obolibrary.org/obo/DOID_1240,,,,,,,,A leukemia that is located_in myeloid tissue.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8692,,,DOID:8910|DOID:8879|DOID:9066|DOID:8878|DOID:9126,SNOMEDCT_US_2016_03_01:190047005|ICD9CM:205|UMLS_CUI:C0023470|ICD10CM:C92.90|SNOMEDCT_US_2016_03_01:269631008|ICD10CM:C92|NCI:C3172|SNOMEDCT_US_2016_03_01:188743000|ICD10CM:C92.9|SNOMEDCT_US_2016_03_01:128934006|SNOMEDCT_US_2016_03_01:37810007|SNOMEDCT_US_2016_03_01:324170002|SNOMEDCT_US_2016_03_01:188732008|SNOMEDCT_US_2016_03_01:94717009|MESH:D007951|SNOMEDCT_US_2016_03_01:154587007|ICD9CM:205.9,myeloid granulocytic leukemia|leukemia myelogenous|Non-Lymphocytic Leukemia,,disease_ontology,,DOID:8692,,,,,,,,,,,,,,,,,,,myeloid leukemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200564,"[""OR3A4P gene""]",,"An olfactory receptor 3A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47883] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 3A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47883] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200564,,,,,,,,,,,,,,,,390756,OR3A4P,OR3A4|OR3A5P,,,,,,,,,,OR3A4P gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200195,"[""ITPK1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491020,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200195,,,,,,,,,,,,,,,,3705,ITPK1,,,,,,,,,,,ITPK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400291,"[""MELK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400116,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400291,,,,,,,,,,,,,,,,,,,,,,,,,,,,MELK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100211,"[""Probable g-protein coupled receptor 83""]",,"A G-protein coupled receptor 83 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NYM4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 83 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NYM4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100211,,,,https://pharos.nih.gov/idg/targets/Q9NYM4,,,,,,,,,,,,,GPR83,GPR72|KIAA1540,,Q9NYM4,,,,,,,,Probable g-protein coupled receptor 83,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3192,"[""neurilemmoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2001,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3192,,,,SNOMEDCT_US_2016_03_01:404022001|SNOMEDCT_US_2016_03_01:189948006|NCI:C3269|UMLS_CUI:C0027809|SNOMEDCT_US_2016_03_01:985004|MESH:D009442,Psammomatous schwannoma|schwannoma,,disease_ontology,,DOID:3192,,,,,,,,,,,,,,,,,,,neurilemmoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100195,"[""Potassium voltage-gated channel subfamily D member 3""]",,"A voltage-gated potassium channel KCND3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9UK17] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300547,,,,,,,,"A voltage-gated potassium channel KCND3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9UK17] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100195,,,,https://pharos.nih.gov/idg/targets/Q9UK17,,,,,,,,,,,,,KCND3,,,Q9UK17,,,,,,,,Potassium voltage-gated channel subfamily D member 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000925,"[""nerve""]",,"Any of the filamentous bands of nervous tissue that connect parts of the nervous system with the other organs, conduct nervous impulses, and are made up of axons and dendrites together with protective and supportive structures.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Any of the filamentous bands of nervous tissue that connect parts of the nervous system with the other organs, conduct nervous impulses, and are made up of axons and dendrites together with protective and supportive structures.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000925,,,,,,,BrendaTissueOBO,,BTO:0000925,,,,,,,,,,,,,,,,,,,nerve,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060195,"[""amyotrophic lateral sclerosis type 3""]",,An amyotrophic lateral sclerosis that has material basis in mutation in loci on chromosome 18.,false,,,http://purl.obolibrary.org/obo/DOID_332,,,,,,,,An amyotrophic lateral sclerosis that has material basis in mutation in loci on chromosome 18.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060195,emitraka,2014-09-16T13:18:38Z,,OMIM:606640,amyotrophic lateral sclerosis 3,,disease_ontology,ALS3,DOID:0060195,,,,,,,,,,,,,,,,,,,amyotrophic lateral sclerosis type 3,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060193,"[""amyotrophic lateral sclerosis type 1""]",,The most common type of familial ALS that has material basis in mutation in the SOD1 gene on chromosome 21.,false,,,http://purl.obolibrary.org/obo/DOID_332,,,,,,,,The most common type of familial ALS that has material basis in mutation in the SOD1 gene on chromosome 21.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060193,emitraka,2014-09-16T13:04:32Z,,OMIM:105400|ICD10CM:G12.2,ALS1|amyotrophic lateral sclerosis 1,,disease_ontology,,DOID:0060193,,,,,,,,,,,,,,,,,,,amyotrophic lateral sclerosis type 1,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060196,"[""amyotrophic lateral sclerosis type 4""]",,An amyotrophic lateral sclerosis with juvenile onset that has material basis in mutation in the SETX gene on chromosome 9.,false,,,http://purl.obolibrary.org/obo/DOID_332,,,,,,,,An amyotrophic lateral sclerosis with juvenile onset that has material basis in mutation in the SETX gene on chromosome 9.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060196,emitraka,2014-09-16T13:49:59Z,,ORDO:357043|OMIM:602433|ICD10CM:G12.2,"amyotrophic lateral sclerosis 4|distal hereditary motor neuropathy with upper motor neuron signs|dHMN with upper motor neuron signs|ALS 4|amyotrophic lateral sclerosis 4, juvenile|distal hereditary motor neuropathy with pyramidal features",,disease_ontology,,DOID:0060196,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,amyotrophic lateral sclerosis type 4,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100333,"[""Proto-oncogene serine/threonine-protein kinase mos""]",,"A proto-oncogene serine/threonine-protein kinase mos that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00540] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300193,,,,,,,,"A proto-oncogene serine/threonine-protein kinase mos that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00540] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100333,,,,https://pharos.nih.gov/idg/targets/P00540,,,,,,,,,,,,,MOS,,,P00540,,,,,,,,Proto-oncogene serine/threonine-protein kinase mos,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300479,"[""SCNN1D subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300330,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300479,,,,,,,,,,,,,,,,,,,,,,,,,,,,SCNN1D subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100375,"[""Nuak family snf1-like kinase 2""]",,"A NUAK family SNF1-like kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H093] |NUAK family snf1-like kinase 2 (SNARK)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300301,,,,,,,,"A NUAK family SNF1-like kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H093] |NUAK family snf1-like kinase 2 (SNARK)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100375,,,,https://pharos.nih.gov/idg/targets/Q9H093,,,,,,,,,,,,,NUAK2,OMPHK2|SNARK,,Q9H093,,,,,,,,Nuak family snf1-like kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200016,"[""CHRNB3 gene""]",,"The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are (hetero)pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1 (MIM 100690), they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits (Groot Kormelink and Luyten, 1997 [PubMed 9009220]). Elliott et al. (1996) [PubMed 8906617] stated that the proposed structure for each subunit is a conserved N-terminal extracellular domain followed by 3 conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region.[supplied by OMIM, Apr 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400500,,,,,,,,"The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are (hetero)pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1 (MIM 100690), they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits (Groot Kormelink and Luyten, 1997 [PubMed 9009220]). Elliott et al. (1996) [PubMed 8906617] stated that the proposed structure for each subunit is a conserved N-terminal extracellular domain followed by 3 conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region.[supplied by OMIM, Apr 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200016,,,,,,,,,,,,,,,,1142,CHRNB3,,,,,,,,,,,CHRNB3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005453,"[""culture condition:CD4+ cell""]",,"CD4, cluster of differentiation 4, is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. In humans CD4+ T helper cells are white blood cells that are an essential part of the human immune system.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002008,,,,,,,,"CD4, cluster of differentiation 4, is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. In humans CD4+ T helper cells are white blood cells that are an essential part of the human immune system.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005453,XPMUser,2013-09-06T09:18:55Z,,,,,BrendaTissueOBO,,BTO:0005453,,,,,,,,,,,,,,,,,,,culture condition:CD4+ cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100206,"[""Camp-dependent protein kinase catalytic subunit gamma""]",,"A cAMP-dependent protein kinase catalytic subunit gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P22612] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300169,,,,,,,,"A cAMP-dependent protein kinase catalytic subunit gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P22612] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100206,,,,https://pharos.nih.gov/idg/targets/P22612,,,,,,,,,,,,,PRKACG,,,P22612,,,,,,,,Camp-dependent protein kinase catalytic subunit gamma,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100309,"[""Olfactory receptor 10H3""]",,"An olfactory receptor 10H3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60404] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10H3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60404] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100309,,,,https://pharos.nih.gov/idg/targets/O60404,,,,,,,,,,,,,OR10H3,,,O60404,,,,,,,,Olfactory receptor 10H3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200041,"[""ADGRB3 gene""]",,"A brain-specific angiogenesis inhibitor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60242] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,"A brain-specific angiogenesis inhibitor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60242] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200041,,,,,,,,,,,,,,,,577,BAI3,KIAA0550,,,,,,,,,,ADGRB3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001035,"[""hematopoietic cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001035,,,,,,,BrendaTissueOBO,,BTO:0001035,,,,,,,,,,,,,,,,,,,hematopoietic cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100403,"[""Olfactory receptor 51m1""]",,"An olfactory receptor 51M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H341] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 51M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H341] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100403,,,,https://pharos.nih.gov/idg/targets/Q9H341,,,,,,,,,,,,,OR51M1,,,Q9H341,,,,,,,,Olfactory receptor 51m1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000368,"[""THR670 in KIT""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000368,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR670 in KIT,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_72795,"[""12-epi-leukotriene B4""]","12-epi-LTB4|VNYSSYRCGWBHLG-CBBLYLIKSA-N|5S,12S-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid|C20H32O4|12(S)-Leukotriene B4|336.46570|336.230|12S-LTB4|InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19+/m0/s1|CCCCC\C=C/C[C@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O|0",A leukotriene that is the 12S-isomer of leukotriene B4.,false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,HMDB:HMDB05089|CAS:83709-73-3|Reaxys:4696045|LIPID_MAPS_instance:LMFA03020015,A leukotriene that is the 12S-isomer of leukotriene B4.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,"(5S,6Z,8E,10E,12S,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid",,chebi_ontology,"12-epi-LTB4|VNYSSYRCGWBHLG-CBBLYLIKSA-N|5S,12S-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid|C20H32O4|12(S)-Leukotriene B4|336.46570|336.230|12S-LTB4|InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19+/m0/s1|CCCCC\C=C/C[C@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O|0",,,CHEBI:72795,,,,,,,,,,,,,,,,,,,,,,,CHEBI:72795,,,,,12-epi-leukotriene B4,,CHEBI:72795,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200519,"[""TEC gene""]",,"The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400133,,,,,,,,"The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200519,,,,,,,,,,,,,,,,7006,TEC,PSCTK4,,,,,,,,,,TEC gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000149,"[""breast""]",,The fore or ventral part of the body between the neck and the abdomen.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000254|http://purl.obolibrary.org/obo/BTO_0000431|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,,The fore or ventral part of the body between the neck and the abdomen.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000149,,,,,,,BrendaTissueOBO,,BTO:0000149,,,,,,,,,,,,,,,,,,,breast,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000046,"[""Y-1 cell""]",,"Mouse adrenal cortex tumor. Mouse, LAF1 male; Tissue: adrenal cortex; Tumor: adrenal tumor.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000851,,,,,,,,"Mouse adrenal cortex tumor. Mouse, LAF1 male; Tissue: adrenal cortex; Tumor: adrenal tumor.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000046,,,,,,,BrendaTissueOBO,Y1 cell,BTO:0000046,,,,,,,,,,,,,,,,,,,Y-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300497,"[""Alpha-9/CHRNA9 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300497,,,,,,,,,,,,,,,,,,,,,,,,,,,,Alpha-9/CHRNA9 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001253,"[""skin""]",,The integument of an animal (as a fur-bearing mammal or a bird) separated from the body usually with its hair or feathers.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000634|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,,The integument of an animal (as a fur-bearing mammal or a bird) separated from the body usually with its hair or feathers.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001253,,,,,,,BrendaTissueOBO,,BTO:0001253,,,,,,,,,,,,,,,,,,,skin,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400358,"[""Calcium-activated potassium channel auxiliary subunit slowpoke- (slo) family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400358,,,,,,,,,,,,,,,,,,,,,,,,,,,,Calcium-activated potassium channel auxiliary subunit slowpoke- (slo) family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1338,"[""congenital dyserythropoietic anemia""]",,"A congenital hemolytic anemia characterized by ineffective erythropoiesis, and resulting from a decrease in the number of red blood cells (RBCs) in the body and a less than normal quantity of hemoglobin in the blood.",false,,,http://purl.obolibrary.org/obo/DOID_589,,,,,,,,"A congenital hemolytic anemia characterized by ineffective erythropoiesis, and resulting from a decrease in the number of red blood cells (RBCs) in the body and a less than normal quantity of hemoglobin in the blood.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1338,,,,OMIM:615631|SNOMEDCT_US_2016_03_01:52951008|NCI:C84646|OMIM:613673|SNOMEDCT_US_2016_03_01:191272005|OMIM:224100|OMIM:224120|ORDO:85|ICD10CM:D64.4|MESH:D000742|OMIM:105600|UMLS_CUI:C0002876,congenital dyshaematopoietic anaemia,,disease_ontology,,DOID:1338,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,congenital dyserythropoietic anemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300539,"[""Kv2.1/KCNB1 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300442,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300539,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv2.1/KCNB1 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100146,"[""Probable g-protein coupled receptor 141""]",,"A G-protein coupled receptor 141 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q7Z602] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 141 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q7Z602] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100146,,,,https://pharos.nih.gov/idg/targets/Q7Z602,,,,,,,,,,,,,GPR141,PGR13,,Q7Z602,,,,,,,,Probable g-protein coupled receptor 141,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2951,"[""motion sickness""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_2952,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2951,,,,MESH:D009041|SNOMEDCT_US_2016_03_01:157749008|ICD10CM:T75.3|ICD9CM:994.6|SNOMEDCT_US_2016_03_01:269278001|SNOMEDCT_US_2016_03_01:212974006|SNOMEDCT_US_2016_03_01:37031009|OMIM:158280|NCI:C34824|UMLS_CUI:C0026603|SNOMEDCT_US_2016_03_01:212973000,Travel Sickness,,disease_ontology,,DOID:2951,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,motion sickness,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000077,"[""LEU590 in LTK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000077,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU590 in LTK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000282,"[""PHE80 in CDK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000282,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE80 in CDK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400243,"[""VRK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400112,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400243,,,,,,,,,,,,,,,,,,,,,,,,,,,,VRK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200587,"[""HK3 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200587,,,,,,,,,,,,,,,,,,,,,,,,,,,,HK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100642,"[""Olfactory receptor 5P2""]",,"An olfactory receptor 5P2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZ92] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5P2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZ92] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100642,,,,https://pharos.nih.gov/idg/targets/Q8WZ92,,,,,,,,,,,,,OR5P2,,,Q8WZ92,,,,,,,,Olfactory receptor 5P2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100814,"[""Urotensin-2 receptor""]",,"A urotensin-2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UKP6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A urotensin-2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UKP6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100814,,,,https://pharos.nih.gov/idg/targets/Q9UKP6,,,,,,,,,,,,,UTS2R,GPR14,,Q9UKP6,,,,,,,,Urotensin-2 receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200431,"[""OR52N2 gene""]",,"An olfactory receptor 52N2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 52N2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200431,,,,,,,,,,,,,,,,390077,OR52N2,,,,,,,,,,,OR52N2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100410,"[""Olfactory receptor 52a5""]",,"An olfactory receptor 52A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H2C5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 52A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H2C5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100410,,,,https://pharos.nih.gov/idg/targets/Q9H2C5,,,,,,,,,,,,,OR52A5,,,Q9H2C5,,,,,,,,Olfactory receptor 52a5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100413,"[""Phosphatidylinositol 4-kinase beta""]",,"phosphatidylinositol 4-kinase beta (PIK4CB)  with  no mutation  in a nonphosphorylated state|A phosphatidylinositol 4-kinase beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UBF8] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391009,,,,,,,,"phosphatidylinositol 4-kinase beta (PIK4CB)  with  no mutation  in a nonphosphorylated state|A phosphatidylinositol 4-kinase beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UBF8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100413,,,,https://pharos.nih.gov/idg/targets/Q9UBF8,,,,,,,,,,,,,PI4KB,PIK4CB,,Q9UBF8,,,,,,,,Phosphatidylinositol 4-kinase beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000327,"[""PAK6 kinase domain""]",,P21 protein (Cdc42/Rac)-activated kinase 6; PAK5; PAK6,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,P21 protein (Cdc42/Rac)-activated kinase 6; PAK5; PAK6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000327,,,,,,,,,,,,,,,,,,,200306,,,,,,,,,PAK6 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100557,"[""Putative olfactory receptor 2w5""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100557,,,,https://pharos.nih.gov/idg/targets/A6NFC9,,,,,,,,,,,,,OR2W5,OR2W5P,,A6NFC9,,,,,,,,Putative olfactory receptor 2w5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200153,"[""FGR gene""]",,"This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400132,,,,,,,,"This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200153,,,,,,,,,,,,,,,,2268,FGR,SRC2,,,,,,,,,,FGR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100071,"[""Cannabinoid receptor 2""]",,"A cannabinoid receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P34972] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300035,,,,,,,,"A cannabinoid receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P34972] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100071,,,,https://pharos.nih.gov/idg/targets/P34972,,,,,,,,,,,,,CNR2,CB2A|CB2B,,P34972,,,,,,,,Cannabinoid receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200039,"[""ADGRB1 gene""]",,"A brain-specific angiogenesis inhibitor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14514] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,"A brain-specific angiogenesis inhibitor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14514] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200039,,,,,,,,,,,,,,,,575,BAI1,,,,,,,,,,,ADGRB1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060135,"[""apraxia""]",,An agnosia that is a loss of the ability to map out physical actions in order to repeat them in functional activities.,false,,,http://purl.obolibrary.org/obo/DOID_4090,,,,,,,,An agnosia that is a loss of the ability to map out physical actions in order to repeat them in functional activities.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060135,lschriml,2011-08-22T12:04:56Z,,,,,disease_ontology,,DOID:0060135,,,,,,,,,,,,,,,,,,,apraxia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060131,"[""alexithymia""]",,"An agnosia that is a deficiency in understanding, processing, or describing emotions.",false,,,http://purl.obolibrary.org/obo/DOID_4090,,,,,,,,"An agnosia that is a deficiency in understanding, processing, or describing emotions.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060131,lschriml,2011-08-22T12:04:56Z,,,,,disease_ontology,,DOID:0060131,,,,,,,,,,,,,,,,,,,alexithymia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400042,"[""Glycoprotein hormone receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400042,,,,,,,,,,,,,,,,,,,,,,,,,,,,Glycoprotein hormone receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000282,"[""MLK1 kinase domain""]",,Mitogen-activated protein kinase kinase kinase 9; MAP3K9; MEKK9; MLK1; PRKE1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase kinase kinase 9; MAP3K9; MEKK9; MLK1; PRKE1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000282,,,,,,,,,,,,,,,,,,,200267,,,,,,,,,MLK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100240,"[""Potassium channel subfamily t member 1""]",,"A potassium channel subfamily T member 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q5JUK3] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300569,,,,,,,,"A potassium channel subfamily T member 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q5JUK3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100240,,,,https://pharos.nih.gov/idg/targets/Q5JUK3,,,,,,,,,,,,,KCNT1,KIAA1422,,Q5JUK3,,,,,,,,Potassium channel subfamily t member 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003870,"[""insect tracheal system""]",,The respiratory system of insects that consists of internal airfilled tubes.,false,,,http://purl.obolibrary.org/obo/BTO_0000203|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The respiratory system of insects that consists of internal airfilled tubes.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003870,,,,,,,BrendaTissueOBO,tracheal system,BTO:0003870,,,,,,,,,,,,,,,,,,,insect tracheal system,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0080006,"[""bone development disease""]",,A bone disease that results_in abnormal growth and development located_in bone or located_in cartilage.,false,,,http://purl.obolibrary.org/obo/DOID_0080001,,,,,,,,A bone disease that results_in abnormal growth and development located_in bone or located_in cartilage.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0080006,,,,,,,disease_ontology,,DOID:0080006,,,,,,,,,,,,,,,,,,,bone development disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0080000,"[""muscular disease""]",,A musculoskeletal system disease that affects the muscles.,false,,,http://purl.obolibrary.org/obo/DOID_17,,,,,,,,A musculoskeletal system disease that affects the muscles.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0080000,,,,,,,disease_ontology,,DOID:0080000,,,,,,,,,,,,,,,,,,,muscular disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0080005,"[""bone remodeling disease""]",,A bone disease that results_in formation or resorption abnormalities located_in bone.,false,,,http://purl.obolibrary.org/obo/DOID_0080001,,,,,,,,A bone disease that results_in formation or resorption abnormalities located_in bone.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0080005,,,,,,,disease_ontology,,DOID:0080005,,,,,,,,,,,,,,,,,,,bone remodeling disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0080001,"[""bone disease""]",,A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function.,false,,,http://purl.obolibrary.org/obo/DOID_65,,,,,,,,A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0080001,,,DOID:1290,MESH:D001847|SNOMEDCT_US_2016_03_01:76069003|SNOMEDCT_US_2016_03_01:203524000|ICD10CM:M89.9|SNOMEDCT_US_2016_03_01:156814002|UMLS_CUI:C0005940|SNOMEDCT_US_2016_03_01:268126004|SNOMEDCT_US_2016_03_01:274145000|SNOMEDCT_US_2016_03_01:308147009,,,disease_ontology,skeletal disease,DOID:0080001,,,,,,,,,,,,,,,,,,,bone disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0080008,"[""ischemic bone disease""]",,A bone disease that results_in an interruption of blood supply located_in bone.,false,,,http://purl.obolibrary.org/obo/DOID_0080001,,,,,,,,A bone disease that results_in an interruption of blood supply located_in bone.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0080008,,,,,,,disease_ontology,,DOID:0080008,,,,,,,,,,,,,,,,,,,ischemic bone disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0080007,"[""bone deterioration disease""]",,A bone structure disease that results_in change or damage of structure located_in bone.,false,,,http://purl.obolibrary.org/obo/DOID_0080010,,,,,,,,A bone structure disease that results_in change or damage of structure located_in bone.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0080007,,,,,,,disease_ontology,,DOID:0080007,,,,,,,,,,,,,,,,,,,bone deterioration disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200571,"[""OR4C6 gene""]",,"An olfactory receptor 4C6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH72] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4C6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH72] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200571,,,,,,,,,,,,,,,,219432,OR4C6,,,,,,,,,,,OR4C6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200401,"[""PDXK gene""]",,"The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03491011,,,,,,,,"The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200401,,,,,,,,,,,,,,,,8566,PDXK,C21orf124|C21orf97|PKH,,,,,,,,,,PDXK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100234,"[""Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform""]",,"A phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform that is encoded in the genome of human. ",false,,,http://www.drugtargetontology.org/dto/DTO_03391039,,,,,,,,"A phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform that is encoded in the genome of human. ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100234,,,,https://pharos.nih.gov/idg/targets/P46020,,,,,,,,,,,,,PHKA1,PHKA,,P46020,,,,,,,,"Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200465,"[""SBK2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400222,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200465,,,,,,,,,,,,,,,,646643,SBK2,SGK069,,,,,,,,,,SBK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000353,"[""THR405 in LIMK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000353,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR405 in LIMK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100432,"[""Serine/threonine-protein kinase plk3""]",,"A serine/threonine-protein kinase PLK3 that is encoded in the genome of human. [PMID:15190214, PRO:KER] |serine/threonine-protein kinase plk3 (PLK3)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300211,,,,,,,,"A serine/threonine-protein kinase PLK3 that is encoded in the genome of human. [PMID:15190214, PRO:KER] |serine/threonine-protein kinase plk3 (PLK3)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100432,,,,https://pharos.nih.gov/idg/targets/Q9H4B4,,,,,,,,,,,,,PLK3,CNK|FNK|PRK,,Q9H4B4,,,,,,,,Serine/threonine-protein kinase plk3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_133068,"[""[des-Arg(9)]-bradykinin""]","RPPGFSPF|9-De-arg-bradykinin|9-Des-arg-BK|903.460|C(=N)(NCCC[C@@H](C(=O)N1[C@H](C(N2[C@H](C(=O)NCC(N[C@H](C(N[C@H](C(=O)N3[C@H](C(=O)N[C@H](C(O)=O)CC=4C=CC=CC4)CCC3)CO)=O)CC=5C=CC=CC5)=O)CCC2)=O)CCC1)N)N|Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe|VCEHWDBVPZFHAG-POFDKVPJSA-N|C44H61N11O10|Des-arg(9)-bradykinin|L-Arg-L-Pro-L-Pro-Gly-L-Phe-L-Ser-L-Pro-L-Phe|InChI=1S/C44H61N11O10/c45-29(15-7-19-48-44(46)47)40(61)55-22-10-18-35(55)42(63)54-21-8-16-33(54)38(59)49-25-36(57)50-30(23-27-11-3-1-4-12-27)37(58)52-32(26-56)41(62)53-20-9-17-34(53)39(60)51-31(43(64)65)24-28-13-5-2-6-14-28/h1-6,11-14,29-35,56H,7-10,15-26,45H2,(H,49,59)(H,50,57)(H,51,60)(H,52,58)(H,64,65)(H4,46,47,48)/t29-,30-,31-,32-,33-,34-,35-/m0/s1|904.025|9-de-L-Argininebradykinin|1-8-Bradykinin|Bradykinin, des-arg(9)|0","An eight-membered oligopeptide comprising Arg, Pro, Pro, Gly, Phe, Ser, Pro and Phe residues joined in sequence. It is an analogue of bradykinin lacking the Arg residue at position 9.",false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,CAS:15958-92-6|Reaxys:4228002|PMID:23318500|Reaxys:10326223|PMID:23742018,"An eight-membered oligopeptide comprising Arg, Pro, Pro, Gly, Phe, Ser, Pro and Phe residues joined in sequence. It is an analogue of bradykinin lacking the Arg residue at position 9.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanine,,chebi_ontology,"RPPGFSPF|9-De-arg-bradykinin|9-Des-arg-BK|903.460|C(=N)(NCCC[C@@H](C(=O)N1[C@H](C(N2[C@H](C(=O)NCC(N[C@H](C(N[C@H](C(=O)N3[C@H](C(=O)N[C@H](C(O)=O)CC=4C=CC=CC4)CCC3)CO)=O)CC=5C=CC=CC5)=O)CCC2)=O)CCC1)N)N|Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe|VCEHWDBVPZFHAG-POFDKVPJSA-N|C44H61N11O10|Des-arg(9)-bradykinin|L-Arg-L-Pro-L-Pro-Gly-L-Phe-L-Ser-L-Pro-L-Phe|InChI=1S/C44H61N11O10/c45-29(15-7-19-48-44(46)47)40(61)55-22-10-18-35(55)42(63)54-21-8-16-33(54)38(59)49-25-36(57)50-30(23-27-11-3-1-4-12-27)37(58)52-32(26-56)41(62)53-20-9-17-34(53)39(60)51-31(43(64)65)24-28-13-5-2-6-14-28/h1-6,11-14,29-35,56H,7-10,15-26,45H2,(H,49,59)(H,50,57)(H,51,60)(H,52,58)(H,64,65)(H4,46,47,48)/t29-,30-,31-,32-,33-,34-,35-/m0/s1|904.025|9-de-L-Argininebradykinin|1-8-Bradykinin|Bradykinin, des-arg(9)|0",,,CHEBI:133068,,,,,,,,,,,,,,,,,,,,,,,CHEBI:133068,,,,,[des-Arg(9)]-bradykinin,,CHEBI:133068,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300283,"[""LIMK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300182,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300283,,,,,,,,,,,,,,,,,,,,,,,,,,,,LIMK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300041,"[""Formyl peptide receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300041,,,,,,,,,,,,,,,,,,,,,,,,,,,,Formyl peptide receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002405,"[""EoL-1 cell""]",,Human eosinophilic leukaemia cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002406,,,,,,,,Human eosinophilic leukaemia cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002405,,,,,,,BrendaTissueOBO,,BTO:0002405,,,,,,,,,,,,,,,,,,,EoL-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200292,"[""OR10A6 gene""]",,"An olfactory receptor 10A6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH74] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10A6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH74] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200292,,,,,,,,,,,,,,,,390093,OR10A6,,,,,,,,,,,OR10A6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100256,"[""Ribosomal protein s6 kinase alpha-6""]",,"ribosomal protein s6 kinase alpha-6 (RSK4(Kin.Dom.2-C-terminal))  with  no mutation  in a nonphosphorylated state|A ribosomal protein S6 kinase alpha-6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UK32] |ribosomal protein s6 kinase alpha-6 (RSK4(Kin.Dom.1-N-terminal))  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300280,,,,,,,,"ribosomal protein s6 kinase alpha-6 (RSK4(Kin.Dom.2-C-terminal))  with  no mutation  in a nonphosphorylated state|A ribosomal protein S6 kinase alpha-6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UK32] |ribosomal protein s6 kinase alpha-6 (RSK4(Kin.Dom.1-N-terminal))  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100256,,,,https://pharos.nih.gov/idg/targets/Q9UK32,,,,,,,,,,,,,RPS6KA6,RSK4,,Q9UK32,,,,,,,,Ribosomal protein s6 kinase alpha-6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004785,"[""Ewing's sarcoma family tumor cell line""]",,"Ewing sarcoma family of tumors (ESFT) belong to the group of neoplasms commonly referred to as small, round, blue-cell tumors of childhood.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000400,,,,,,,,"Ewing sarcoma family of tumors (ESFT) belong to the group of neoplasms commonly referred to as small, round, blue-cell tumors of childhood.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004785,mgr,2010-10-04T09:40:39Z,,,,,BrendaTissueOBO,ESFT cell line,BTO:0004785,,,,,,,,,,,,,,,,,,,Ewing's sarcoma family tumor cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002589,"[""H-7721 cell""]",,Human hepatocarcinoma cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0000578|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human hepatocarcinoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002589,,,,,,,BrendaTissueOBO,H7721 cell,BTO:0002589,,,,,,,,,,,,,,,,,,,H-7721 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000065,"[""LEU195 in GSK3A""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000065,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU195 in GSK3A,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002097,"[""pharyngeal cavity""]",,The space enclosed by the walls of the pharynx.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The space enclosed by the walls of the pharynx.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002097,,,,,,,BrendaTissueOBO,cavitas pharyngis,BTO:0002097,,,,,,,,,,,,,,,,,,,pharyngeal cavity,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200289,"[""MAP3K7 gene""]",,"The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400286,,,,,,,,"The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200289,,,,,,,,,,,,,,,,6885,MAP3K7,TAK1,,,,,,,,,,MAP3K7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117481,"[""Thyroid hormone receptor beta""]",,"A thyroid hormone receptor beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10828] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117460,,,,,,,,"A thyroid hormone receptor beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10828] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117481,,,,https://pharos.nih.gov/idg/targets/P10828,,,,,,,,,,,,,THRB,NR1A2,,P10828,,,,,,,,Thyroid hormone receptor beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2436,"[""glomangioma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5238,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2436,,,,SNOMEDCT_US_2016_03_01:7429002|MESH:D005918|NCI:C4222|UMLS_CUI:C0334421,,,disease_ontology,,DOID:2436,,,,,,,,,,,,,,,,,,,glomangioma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100311,"[""Olfactory receptor 10h5""]",,"An olfactory receptor 10H5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10H5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100311,,,,https://pharos.nih.gov/idg/targets/Q8NGA6,,,,,,,,,,,,,OR10H5,,,Q8NGA6,,,,,,,,Olfactory receptor 10h5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13580,"[""cholestasis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4138,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13580,,,,ICD9CM:576.2|SNOMEDCT_US_2016_03_01:197446008|SNOMEDCT_US_2016_03_01:33688009|SNOMEDCT_US_2016_03_01:197447004|SNOMEDCT_US_2016_03_01:30144000|ICD10CM:K83.1|UMLS_CUI:C0008370|NCI:C83006|MESH:D002779,Obstruction of bile duct|bile occlusion,,disease_ontology,,DOID:13580,,,,,,,,,,,,,,,,,,,cholestasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001214,"[""Yoshida sarcoma cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001207,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001214,,,,,,,BrendaTissueOBO,,BTO:0001214,,,,,,,,,,,,,,,,,,,Yoshida sarcoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001271,"[""leukemia cell""]",,A cancer cell of the white blood cells. Leukaemias are grouped by how quickly the disease develops (acute or chronic) as well as by the type of blood cell that is affected.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000580,,,,,,,,A cancer cell of the white blood cells. Leukaemias are grouped by how quickly the disease develops (acute or chronic) as well as by the type of blood cell that is affected.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001271,,,,,,,BrendaTissueOBO,,BTO:0001271,,,,,,,,,,,,,,,,,,,leukemia cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300065,"[""Melatonin receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300065,,,,,,,,,,,,,,,,,,,,,,,,,,,,Melatonin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4471,"[""chromophobe renal cell carcinoma""]",,"A renal cell carcinoma that has_material_basis_in chromophobe cell that appear pale when viewed under microscope, but that are larger and display different features than clear cells.",false,,,http://purl.obolibrary.org/obo/DOID_4450,,,,,,,,"A renal cell carcinoma that has_material_basis_in chromophobe cell that appear pale when viewed under microscope, but that are larger and display different features than clear cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4471,,,,SNOMEDCT_US_2016_03_01:128667008|MESH:D002292|UMLS_CUI:C1266042|NCI:C4146,"kidney chromophobe|chromophobe adenocarcinoma|Chromophobe carcinoma of kidney|renal cell carcinoma, chromophobe cell",,disease_ontology,,DOID:4471,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,chromophobe renal cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002316,"[""stellate cell""]",,"Any cell having a star-shaped appearance produced by numerous processes that extend in different directions, such as the Kupffer cells in the liver, astrocytes, and granule cells in the granular layers of the cerebral and cerebellar cortices.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002322,,,,,,,,"Any cell having a star-shaped appearance produced by numerous processes that extend in different directions, such as the Kupffer cells in the liver, astrocytes, and granule cells in the granular layers of the cerebral and cerebellar cortices.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002316,,,,,,,BrendaTissueOBO,,BTO:0002316,,,,,,,,,,,,,,,,,,,stellate cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000263,"[""PHE435 in ITK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000263,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE435 in ITK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000333,"[""PFPK5(P.falciparum) kinase domain""]",,Protein Kinase 5; cdk-related protein kinase 6; cyclin-dependent kinase; MAL13P1.279; PK5,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Protein Kinase 5; cdk-related protein kinase 6; cyclin-dependent kinase; MAL13P1.279; PK5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000333,,,,,,,,,,,,,,,,,,,200316,,,,,,,,,PFPK5(P.falciparum) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200158,"[""GAK gene""]",,"In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400115,,,,,,,,"In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200158,,,,,,,,,,,,,,,,2580,GAK,,,,,,,,,,,GAK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12385,"[""shigellosis""]",,"A primary bacterial infectious disease that results_in infection located_in epithelium of colon, has_material_basis_in Shigella boydii, has_material_basis_in Shigella dysenteriae, has_material_basis_in Shigella flexneri, or has_material_basis_in Shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. The bacteria are transmitted_by ingestion of food and water contaminated with feces.",false,,,http://purl.obolibrary.org/obo/DOID_0050338,,,,,,,,"A primary bacterial infectious disease that results_in infection located_in epithelium of colon, has_material_basis_in Shigella boydii, has_material_basis_in Shigella dysenteriae, has_material_basis_in Shigella flexneri, or has_material_basis_in Shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. The bacteria are transmitted_by ingestion of food and water contaminated with feces.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12385,,,DOID:12950|DOID:925|DOID:924|DOID:11378|DOID:2041,ICD10CM:A03.0|KEGG:05131|ICD10CM:A03.9|SNOMEDCT_US_2016_03_01:36188001|SNOMEDCT_US_2016_03_01:154272001|ICD10CM:A03|SNOMEDCT_US_2016_03_01:186104004|SNOMEDCT_US_2016_03_01:187272003|ICD9CM:004.1|ICD9CM:004|SNOMEDCT_US_2016_03_01:186105003|UMLS_CUI:C0302359|SNOMEDCT_US_2016_03_01:266175007|SNOMEDCT_US_2016_03_01:55760004|UMLS_CUI:C0013371|UMLS_CUI:C0302361|ICD9CM:004.2|ICD10CM:A03.1|MESH:D004405|SNOMEDCT_US_2016_03_01:111817006|SNOMEDCT_US_2016_03_01:186108001|UMLS_CUI:C0302358|ICD9CM:004.9|SNOMEDCT_US_2016_03_01:34335000|UMLS_CUI:C0302360|ICD9CM:004.3|ICD10CM:A03.2|SNOMEDCT_US_2016_03_01:66301008|ICD9CM:004.0,Shigella flexneri infectious disease|Shigella boydii infectious disease|Shigella sonnei infectious disease|bacillary dysentery|Shigella gastroenteritis,,disease_ontology,,DOID:12385,,,,,,,,,,,,,,,,,,,shigellosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12384,"[""dysentery""]",,"An intestinal infectious disease that involves inflammation of the intestines, especially colon, due to chemical irritants, bacteria, protozoa, or parasitic worms, which results in severe diarrhea with passage of mucus and blood.",false,,,http://purl.obolibrary.org/obo/DOID_100,,,,,,,,"An intestinal infectious disease that involves inflammation of the intestines, especially colon, due to chemical irritants, bacteria, protozoa, or parasitic worms, which results in severe diarrhea with passage of mucus and blood.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12384,,,,UMLS_CUI:C0013369|SNOMEDCT_US_2016_03_01:266180003|SNOMEDCT_US_2016_03_01:154279005|MESH:D004403|SNOMEDCT_US_2016_03_01:111939009|SNOMEDCT_US_2016_03_01:186165000|SNOMEDCT_US_2016_03_01:186167008|ICD9CM:009.2|SNOMEDCT_US_2016_03_01:236076004|SNOMEDCT_US_2016_03_01:19213003|SNOMEDCT_US_2016_03_01:154268000|SNOMEDCT_US_2016_03_01:266173000,Infectious diarrhea,,disease_ontology,,DOID:12384,,,,,,,,,,,,,,,,,,,dysentery,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12388,"[""neurohypophyseal diabetes insipidus""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_53|http://purl.obolibrary.org/obo/DOID_26|http://purl.obolibrary.org/obo/DOID_9409,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12388,,,,MESH:D020790|SNOMEDCT_US_2016_03_01:15771004|SNOMEDCT_US_2016_03_01:190484000|OMIM:125700|NCI:C84933|OMIM:304900|UMLS_CUI:C0687720|SNOMEDCT_US_2016_03_01:154699008|SNOMEDCT_US_2016_03_01:64410003|SNOMEDCT_US_2016_03_01:45369008|SNOMEDCT_US_2016_03_01:267393007,Vasopressin deficiency|central diabetes insipidus|vasopressin defective diabetes insipidus|Pituitary diabetes insipidus,,disease_ontology,,DOID:12388,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,neurohypophyseal diabetes insipidus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12387,"[""nephrogenic diabetes insipidus""]",,An impaired renal function disease characterized by a complete or partial resistance of the kidneys to vasopressin (ADH).,false,,,http://purl.obolibrary.org/obo/DOID_11705,,,,,,,,An impaired renal function disease characterized by a complete or partial resistance of the kidneys to vasopressin (ADH).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12387,,,,MESH:D018500|UMLS_CUI:C0162283|NCI:C84919|ICD10CM:N25.1|OMIM:125800|OMIM:304800|ORDO:223|SNOMEDCT_US_2016_03_01:111395007|SNOMEDCT_US_2016_03_01:123294004|ICD9CM:588.1,,,disease_ontology,vasopressin-resistant diabetes insipidus,DOID:12387,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping submitted by NeuroDevNet. [LS].",,nephrogenic diabetes insipidus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000152,"[""ERK8 kinase domain""]",,Mitogen-activated protein kinase 15; ERK7; ERK8; MAPK15,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase 15; ERK7; ERK8; MAPK15,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000152,,,,,,,,,,,,,,,,,,,200156,,,,,,,,,ERK8 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003617,"[""peritoneal exudate""]",,A term most commonly used to describe the fluid drained from the peritoneal cavity some time after the injection of an irritant solution. For example: a standard method for obtaining neutrophil leucocytes is to inject intraperitoneally saline with glycogen (to activate complement) and drain off the leucocyte rich peritoneal exudate some hours later.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A term most commonly used to describe the fluid drained from the peritoneal cavity some time after the injection of an irritant solution. For example: a standard method for obtaining neutrophil leucocytes is to inject intraperitoneally saline with glycogen (to activate complement) and drain off the leucocyte rich peritoneal exudate some hours later.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003617,,,,,,,BrendaTissueOBO,,BTO:0003617,,,,,,,,,,,,,,,,,,,peritoneal exudate,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300541,"[""Kv3.1/KCNC1 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300443,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300541,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv3.1/KCNC1 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100799,"[""Taste receptor type 2 member 9""]",,"A taste receptor type 2 member 9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300014,,,,,,,,"A taste receptor type 2 member 9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100799,,,,https://pharos.nih.gov/idg/targets/Q9NYW1,,,,,,,,,,,,,TAS2R9,,,Q9NYW1,,,,,,,,Taste receptor type 2 member 9,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050678,"[""Blau syndrome""]",,"An autosomal dominant disease characterized by familial granulomatous arthritis, uveitis and skin granulomas. It has material basis in mutations in the NOD2/CARD15 genes.",false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,"An autosomal dominant disease characterized by familial granulomatous arthritis, uveitis and skin granulomas. It has material basis in mutations in the NOD2/CARD15 genes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050678,,,,SNOMEDCT:699861000|OMIM:186580|NCI:C116794,Jabs syndrome|ARTHROCUTANEOUVEAL GRANULOMATOSIS,,disease_ontology,,DOID:0050678,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Blau syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050676,"[""Birt-Hogg-Dube syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050676,,,,OMIM:135150,,,disease_ontology,,DOID:0050676,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Birt-Hogg-Dube syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050675,"[""Birk-Barel syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050675,,,,OMIM:612292,BIRK-BAREL MENTAL RETARDATION DYSMORPHISM SYNDROME,,disease_ontology,,DOID:0050675,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Birk-Barel syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050670,"[""ataxic cerebral palsy""]",,"A cerebral palsy that is caused by damage to the cerebellum, which affects muscle coordination, particularly in the limb. Some individuals suffer from hypotonia, tremors, difficulty with visual and/or auditory processing.",false,,,http://purl.obolibrary.org/obo/DOID_1969,,,,,,,,"A cerebral palsy that is caused by damage to the cerebellum, which affects muscle coordination, particularly in the limb. Some individuals suffer from hypotonia, tremors, difficulty with visual and/or auditory processing.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050670,,,,,hypotonic cerebral palsy,,disease_ontology,,DOID:0050670,,,,,,,,,,,,,,,,,,,ataxic cerebral palsy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000375,"[""keratinocyte cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000375,,,,,,,BrendaTissueOBO,KC,BTO:0000375,,,,,,,,,,,,,,,,,,,keratinocyte cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4250,"[""conjunctivochalasis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4251,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4250,,,,ICD10CM:H11.82|ICD9CM:372.81|SNOMEDCT_US_2016_03_01:408663001|UMLS_CUI:C0878693,,,disease_ontology,,DOID:4250,,,,,,,,,,,,,,,,,,,conjunctivochalasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200202,"[""KCNG2 gene""]",,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit of the voltage-gated potassium channel. The delayed-rectifier type channels containing this subunit may contribute to cardiac action potential repolarization. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400550,,,,,,,,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit of the voltage-gated potassium channel. The delayed-rectifier type channels containing this subunit may contribute to cardiac action potential repolarization. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200202,,,,,,,,,,,,,,,,26251,KCNG2,KCNF2,,,,,,,,,,KCNG2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000460,"[""fibrosarcoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000453|http://purl.obolibrary.org/obo/BTO_0000400,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000460,,,,,,,BrendaTissueOBO,,BTO:0000460,,,,,,,,,,,,,,,,,,,fibrosarcoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217548,"[""NR1I3 gene""]",,"This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_00217466,,,,,,,,"This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217548,,,,,,,,,,,,,,,,9970,NR1I3,CAR,,,,,,,,,,NR1I3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001360,"[""decidua""]",,1: The part of the mucous membrane lining the uterus that in higher placental mammals undergoes special modifications in preparation for and during pregnancy and is cast off at parturition. 2: The part of the mucous membrane of the uterus cast off in the process of menstruation.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,1: The part of the mucous membrane lining the uterus that in higher placental mammals undergoes special modifications in preparation for and during pregnancy and is cast off at parturition. 2: The part of the mucous membrane of the uterus cast off in the process of menstruation.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001360,,,,,,,BrendaTissueOBO,uterine decidua,BTO:0001360,,,,,,,,,,,,,,,,,,,decidua,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200284,"[""MAP3K2 gene""]",,"The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400186,,,,,,,,"The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200284,,,,,,,,,,,,,,,,10746,MAP3K2,MAPKKK2|MEKK2,,,,,,,,,,MAP3K2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100288,"[""Solute carrier family 26 member 6""]",,"A solute carrier family 26 member 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BXS9] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300368,,,,,,,,"A solute carrier family 26 member 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BXS9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100288,,,,https://pharos.nih.gov/idg/targets/Q9BXS9,,,,,,,,,,,,,SLC26A6,,,Q9BXS9,,,,,,,,Solute carrier family 26 member 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000100,"[""CSNK1E kinase domain""]",,"Casein kinase 1, epsilon; CK1e; CSNK1E; HCKIE; MGC10398",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Casein kinase 1, epsilon; CK1e; CSNK1E; HCKIE; MGC10398",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000100,,,,,,,,,,,,,,,,,,,200099,,,,,,,,,CSNK1E kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217559,"[""NR2F2 gene""]",,"This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_00217471,,,,,,,,"This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217559,,,,,,,,,,,,,,,,7026,NR2F2,ARP1|TFCOUP2,,,,,,,,,,NR2F2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200280,"[""NPSR1 gene""]",,"A neuropeptide S receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q6W5P4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400070,,,,,,,,"A neuropeptide S receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q6W5P4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200280,,,,,,,,,,,,,,,,387129,NPSR1,GPR154|GPRA|PGR14,,,,,,,,,,NPSR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400118,"[""ACK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400118,,,,,,,,,,,,,,,,,,,,,,,,,,,,ACK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200361,"[""NEK7 gene""]",,"NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002]",false,,,http://www.drugtargetontology.org/dto/DTO_03400197,,,,,,,,"NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200361,,,,,,,,,,,,,,,,140609,NEK7,,,,,,,,,,,NEK7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000793,"[""SH-SY5Y cell""]",,Human neuroblastoma clonal subline of the neuroepithelioma cell line SK-N-SH that had been established in 1970 from the bone marrow biopsy of a 4-year-old girl with metastatic neuroblastoma.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human neuroblastoma clonal subline of the neuroepithelioma cell line SK-N-SH that had been established in 1970 from the bone marrow biopsy of a 4-year-old girl with metastatic neuroblastoma.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000793,,,,,,,BrendaTissueOBO,SK-N-SH-SY5Y cell|SHSY-5Y cell|SY5Y cell|SK-SH-SY5Y cell,BTO:0000793,,,,,,,,,,,,,,,,,,,SH-SY5Y cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300331,"[""Anion channel-forming bestrophin (bestrophin) family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300331,,,,,,,,,,,,,,,,,,,,,,,,,,,,Anion channel-forming bestrophin (bestrophin) family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400464,"[""SCN1B family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400370,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400464,,,,,,,,,,,,,,,,,,,,,,,,,,,,SCN1B family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4723,"[""intracranial hypotension""]",,,false,,,http://purl.obolibrary.org/obo/DOID_936,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4723,,,,UMLS_CUI:C0524812|MESH:D019585|SNOMEDCT_US_2016_03_01:433691000124104,,,disease_ontology,,DOID:4723,,,,,,,,,,,,,,,,,,,intracranial hypotension,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200331,"[""OR11H2 gene""]",,"An olfactory receptor 11H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH07] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 11H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH07] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200331,,,,,,,,,,,,,,,,79334,OR11H2,C14orf15|OR11H2P,,,,,,,,,,OR11H2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100122,"[""Glucagon-like peptide 1 receptor""]",,"A glucagon-like peptide 1 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P43220] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300047,,,,,,,,"A glucagon-like peptide 1 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P43220] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100122,,,,https://pharos.nih.gov/idg/targets/P43220,,,,,,,,,,,,,GLP1R,,,P43220,,,,,,,,Glucagon-like peptide 1 receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6179,"[""ovarian small cell carcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4001,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6179,,,,NCI:C27390,,,disease_ontology,,DOID:6179,,,,,,,,,,,,,,,,,,,ovarian small cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100563,"[""Olfactory receptor 3A3""]",,"An olfactory receptor 3A3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47888] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 3A3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47888] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100563,,,,https://pharos.nih.gov/idg/targets/P47888,,,,,,,,,,,,,OR3A3,OR3A6|OR3A7|OR3A8P,,P47888,,,,,,,,Olfactory receptor 3A3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1858,"[""McCune Albright syndrome""]",,"An autosomal dominant disease that involves skin pigmentation, bone and hormonal problems along with premature puberty. It has material basis in mutations in the GNAS1 gene.",false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,"An autosomal dominant disease that involves skin pigmentation, bone and hormonal problems along with premature puberty. It has material basis in mutations in the GNAS1 gene.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1858,,,DOID:11345,ICD10CM:Q78.1|UMLS_CUI:C0016065|SNOMEDCT_US_2016_03_01:205508003|MESH:D005357|UMLS_CUI:C0016063|OMIM:174800|MESH:D005359|SNOMEDCT_US_2016_03_01:10623005|SNOMEDCT_US_2016_03_01:36517007|ICD9CM:756.54|NCI:C34610,polyostotic fibrous dysplasia|fibrous dysplasia of bone (disorder)|fibrous Dysplasia of bone|osteitis fibrosa disseminata,,disease_ontology,,DOID:1858,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,McCune Albright syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200452,"[""RIPK3 gene""]",,"The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400124,,,,,,,,"The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200452,,,,,,,,,,,,,,,,11035,RIPK3,RIP3,,,,,,,,,,RIPK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11714,"[""gestational diabetes""]",,,false,,,http://purl.obolibrary.org/obo/DOID_9351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11714,,,,ICD10CM:O24.4|SNOMEDCT_US_2016_03_01:11687002|EFO:0004593|SNOMEDCT_US_2016_03_01:237629002|SNOMEDCT_US_2016_03_01:199232003|UMLS_CUI:C0085207|SNOMEDCT_US_2016_03_01:359964007|NCI:C34942|SNOMEDCT_US_2016_03_01:393568003|MESH:D016640,Maternal gestational diabetes mellitus|Gestational diabetes mellitus|GDM,,disease_ontology,,DOID:11714,,,,,,,,,,,,,,,,,,,gestational diabetes,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1510,"[""personality disorder""]",,A disease of mental health that involve long-term patterns of thoughts and behaviors that cause serious problems with relationships and work.,false,,,http://purl.obolibrary.org/obo/DOID_150,,,,,,,,A disease of mental health that involve long-term patterns of thoughts and behaviors that cause serious problems with relationships and work.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1510,,,,ICD9CM:301.8|SNOMEDCT_US_2016_03_01:191770003|ICD9CM:301.89|UMLS_CUI:C0029707|SNOMEDCT_US_2016_03_01:268759009|SNOMEDCT_US_2016_03_01:191776009|SNOMEDCT_US_2016_03_01:268635005,character disorder,,disease_ontology,,DOID:1510,,,,,,,,,,,,,,,,,,,personality disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1602,"[""lymphadenitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_9942,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1602,,,DOID:9941|DOID:1600,SNOMEDCT_US_2016_03_01:19471005|ICD9CM:683|SNOMEDCT_US_2016_03_01:200696002|SNOMEDCT_US_2016_03_01:274737001|NCI:C26978|ICD10CM:L04.9|SNOMEDCT_US_2016_03_01:32035007|ICD9CM:289.1|ICD10CM:L04|SNOMEDCT_US_2016_03_01:154836001|SNOMEDCT_US_2016_03_01:287688007|ICD10CM:I88.9|MESH:D008199|NCI:C26821|SNOMEDCT_US_2016_03_01:154838000|UMLS_CUI:C0157705|NCI:C26966|ICD10CM:I88.1|SNOMEDCT_US_2016_03_01:41174002|UMLS_CUI:C0024205|SNOMEDCT_US_2016_03_01:156318008|UMLS_CUI:C0154304,acute lymphadenitis|chronic adenitis|acute adenitis|chronic Lymphadenitis|Inflammation of lymph node|Adenitis,,disease_ontology,,DOID:1602,,,,,,,,,,,,,,,,,,,lymphadenitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10762,"[""portal hypertension""]",,,false,,,http://purl.obolibrary.org/obo/DOID_272,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10762,,,,ICD10CM:K76.6|ICD9CM:572.3|SNOMEDCT_US_2016_03_01:155821005|SNOMEDCT_US_2016_03_01:34742003|UMLS_CUI:C0020541|MESH:D006975|NCI:C3119,,,disease_ontology,,DOID:10762,,,,,,,,,,,,,,,,,,,portal hypertension,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10763,"[""hypertension""]",,An artery disease characterized by chronic elevated blood pressure in the arteries.,false,,,http://purl.obolibrary.org/obo/DOID_0050828,,,,,,,,An artery disease characterized by chronic elevated blood pressure in the arteries.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10763,,,,SNOMEDCT_US_2016_03_01:194756002|MESH:D006973|SNOMEDCT_US_2016_03_01:194760004|ICD10CM:I10|SNOMEDCT_US_2016_03_01:266287006|ICD9CM:997.91|ICD9CM:401-405.99|NCI:C3117|SNOMEDCT_US_2016_03_01:155295004|SNOMEDCT_US_2016_03_01:155302005|EFO:0000537|SNOMEDCT_US_2016_03_01:194794002|SNOMEDCT_US_2016_03_01:38341003|SNOMEDCT_US_2016_03_01:194757006|SNOMEDCT_US_2016_03_01:195537001|ICD10CM:I10-I15|UMLS_CUI:C0020538,hyperpiesia|High blood pressure (& [essential hypertension])|HTN|vascular hypertensive disorder,,disease_ontology,hypertensive disease,DOID:10763,,,,,,,,,,,,,,,,,,,hypertension,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12663,"[""blastomycosis""]",,"A primary systemic mycosis that results_in a systemic fungal infection, has_material_basis_in Blastomyces dermatitidis, transmitted_by airborne spores and has_symptom skin lesions, has_symptom lung lesions and has_symptom pleural thickening.",false,,,http://purl.obolibrary.org/obo/DOID_0050292,,,,,,,,"A primary systemic mycosis that results_in a systemic fungal infection, has_material_basis_in Blastomyces dermatitidis, transmitted_by airborne spores and has_symptom skin lesions, has_symptom lung lesions and has_symptom pleural thickening.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12663,,,DOID:13067,SNOMEDCT_US_2016_03_01:154402000|ICD10CM:B40.9|NCI:C34429|SNOMEDCT_US_2016_03_01:266217003|SNOMEDCT_US_2016_03_01:187075006|SNOMEDCT_US_2016_03_01:191950004|ICD9CM:116.0|SNOMEDCT_US_2016_03_01:187064007|NCI:C34428|MESH:D001759|ICD9CM:116|SNOMEDCT_US_2016_03_01:69996000|CSP:1988-4119|ICD10CM:B40|SNOMEDCT_US_2016_03_01:10673008|SNOMEDCT_US_2016_03_01:187071002|UMLS_CUI:C0005716|SNOMEDCT_US_2016_03_01:187484004,Infection by Blastomyces dermatitidis|North American blastomycosis|Chicago disease|Blastomyces Dermatitidis Infection|Gilchrist's disease|Blastomycotic infection,,disease_ontology,,DOID:12663,,,,,,,,,,,,,,,,,,,blastomycosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12661,"[""tooth ankylosis""]",,OMIM mapping confirmed by DO. [LS].,false,,,http://purl.obolibrary.org/obo/DOID_214|http://purl.obolibrary.org/obo/DOID_227,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12661,,,,ICD10CM:K03.5|MESH:D020254|OMIM:157950|SNOMEDCT_US_2016_03_01:14901003|ICD9CM:521.6|UMLS_CUI:C0155930,Ankylosis of tooth (disorder)|Ankylosis of teeth,,disease_ontology,,DOID:12661,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,tooth ankylosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12662,"[""paracoccidioidomycosis""]",,"A primary systemic mycosis that results_in systemic fungal infection located_in mucosa, located_in lymph nodes, located_in bone, located_in skin or located_in lungs, has_material_basis_in Paracoccidioides brasiliensis.",false,,,http://purl.obolibrary.org/obo/DOID_0050292,,,,,,,,"A primary systemic mycosis that results_in systemic fungal infection located_in mucosa, located_in lymph nodes, located_in bone, located_in skin or located_in lungs, has_material_basis_in Paracoccidioides brasiliensis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12662,,,,ICD10CM:B41|SNOMEDCT_US_2016_03_01:187486002|UMLS_CUI:C0030409|SNOMEDCT_US_2016_03_01:59925007|NCI:C34891|ICD10CM:B41.9|ICD9CM:116.1|MESH:D010229|SNOMEDCT_US_2016_03_01:36866003|SNOMEDCT_US_2016_03_01:187074005,"Paracoccidioidomycosis, unspecified (disorder)|Paracoccidioidomycosis (disorder)|Paracoccidioidomycosis NOS (disorder)|Mucocutaneous-lymphangitic paracoccidioidomycosis|Mucocutaneous-lymphangitic paracoccidioidomycosis (disorder)|paracoccidioidal mycosis",,disease_ontology,,DOID:12662,,,,,,,,,,,,,,,,,,,paracoccidioidomycosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100227,"[""Potassium channel subfamily K member 18""]",,"A potassium channel subfamily K member 18 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z418] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300359,,,,,,,,"A potassium channel subfamily K member 18 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z418] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100227,,,,https://pharos.nih.gov/idg/targets/Q7Z418,,,,,,,,,,,,,KCNK18,TRESK|TRIK,,Q7Z418,,,,,,,,Potassium channel subfamily K member 18,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000135,"[""EPHA3 kinase domain""]",,EPH receptor A3; EK4; EPHA3; ETK; ETK1; HEK; HEK4; TYRO4,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,EPH receptor A3; EK4; EPHA3; ETK; ETK1; HEK; HEK4; TYRO4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000135,,,,,,,,,,,,,,,,,,,200137,,,,,,,,,EPHA3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000128,"[""blastula""]",,"The usually spherical structure produced by cleavage of a zygote, consisting of a single layer of cells (blastoderm) surrounding a fluid-filled cavity (blastocoele).",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The usually spherical structure produced by cleavage of a zygote, consisting of a single layer of cells (blastoderm) surrounding a fluid-filled cavity (blastocoele).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000128,,,,,,,BrendaTissueOBO,blastosphere,BTO:0000128,,,,,,,,,,,,,,,,,,,blastula,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200568,"[""WNK2 gene""]",,"The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400244,,,,,,,,"The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200568,,,,,,,,,,,,,,,,65268,WNK2,KIAA1760|PRKWNK2|SDCCAG43,,,,,,,,,,WNK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100275,"[""Piezo-type mechanosensitive ion channel component 2""]",,"A piezo-type mechanosensitive ion channel component 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H5I5] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300366,,,,,,,,"A piezo-type mechanosensitive ion channel component 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H5I5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100275,,,,https://pharos.nih.gov/idg/targets/Q9H5I5,,,,,,,,,,,,,PIEZO2,C18orf30|C18orf58|FAM38B,,Q9H5I5,,,,,,,,Piezo-type mechanosensitive ion channel component 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9746,"[""hemorrhoid""]",,"A pelvic varix disease characterized by swollen, inflamed veins around the anus or lower rectum.",false,,,http://purl.obolibrary.org/obo/DOID_9742,,,,,,,,"A pelvic varix disease characterized by swollen, inflamed veins around the anus or lower rectum.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9746,,,,SNOMEDCT_US_2016_03_01:155477004|MESH:D006484|SNOMEDCT_US_2016_03_01:195472000|ICD10CM:K64|SNOMEDCT_US_2016_03_01:155469003|ICD9CM:455|UMLS_CUI:C0019112|SNOMEDCT_US_2016_03_01:70153002|NCI:C26792,hemorrhoidal disease,,disease_ontology,,DOID:9746,,,,,,,,,,,,,,,,,,,hemorrhoid,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200410,"[""OR52A5 gene""]",,"An olfactory receptor 52A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H2C5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 52A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H2C5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200410,,,,,,,,,,,,,,,,390054,OR52A5,,,,,,,,,,,OR52A5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003031,"[""HCA-7 cell""]",,HCA-7 cell line was originally derived from human colonic carcinoma.,false,,,http://purl.obolibrary.org/obo/BTO_0000797|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,HCA-7 cell line was originally derived from human colonic carcinoma.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003031,,,,,,,BrendaTissueOBO,,BTO:0003031,,,,,,,,,,,,,,,,,,,HCA-7 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100273,"[""Pannexin-3""]",,"A pannexin-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96QZ0] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300365,,,,,,,,"A pannexin-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96QZ0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100273,,,,https://pharos.nih.gov/idg/targets/Q96QZ0,,,,,,,,,,,,,PANX3,,,Q96QZ0,,,,,,,,Pannexin-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400509,"[""GABRA4 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400509,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRA4 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3086,"[""gingival overgrowth""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1483,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3086,,,,SNOMEDCT_US_2016_03_01:54711002|ICD10CM:K06.1|SNOMEDCT_US_2016_03_01:196375006|MESH:D019214|SNOMEDCT_US_2016_03_01:271083000|UMLS_CUI:C0376480,Gingival enlargement NOS|Gingival enlargement (disorder)|Gingival enlargement NOS (disorder),,disease_ontology,,DOID:3086,,,,,,,,,,,,,,,,,,,gingival overgrowth,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200149,"[""FGFR1 gene""]",,"The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400158,,,,,,,,"The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200149,,,,,,,,,,,,,,,,2260,FGFR1,BFGFR|CEK|FGFBR,,,,,,,,,,FGFR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000067,"[""H3 relaxin""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000067,,,,,,,,,,,,,,,,,,,,,,,,,,,,H3 relaxin,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060058,"[""lymphoma""]",,A hematologic cancer that affects lymphocytes that reside in the lymphatic system and in blood-forming organs.,false,,,http://purl.obolibrary.org/obo/DOID_2531,,,,,,,,A hematologic cancer that affects lymphocytes that reside in the lymphatic system and in blood-forming organs.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060058,,,DOID:1033|DOID:353,SNOMEDCT_US_2016_03_01:134218000|UMLS_CUI:C0024299|SNOMEDCT_US_2016_03_01:189965002|SNOMEDCT_US_2016_03_01:21964009|SNOMEDCT_US_2016_03_01:414628006|SNOMEDCT_US_2016_03_01:118600007|SNOMEDCT_US_2016_03_01:115244002|SNOMEDCT_US_2016_03_01:189959002|NCI:C7065|UMLS_CUI:C0598798|SNOMEDCT_US_2016_03_01:188704004|SNOMEDCT_US_2016_03_01:188676008|MESH:D008223|NCI:C3208|SNOMEDCT_US_2016_03_01:188695001|SNOMEDCT_US_2016_03_01:269627002|ICD10CM:C85.9|SNOMEDCT_US_2016_03_01:188694002,lymphoid cancer,,disease_ontology,,DOID:0060058,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,lymphoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060056,"[""hypersensitivity reaction disease""]",,An immune system disease that has material basis in abnormal immune responses.,false,,,http://purl.obolibrary.org/obo/DOID_2914,,,,,,,,An immune system disease that has material basis in abnormal immune responses.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060056,,,,,,,disease_ontology,,DOID:0060056,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,hypersensitivity reaction disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060055,"[""popliteal pterygium syndrome""]",,"An autosomal dominant disease characterized by abnormal development of the face, skin and genitals. Clinical expressions of the disease include cleft lip, with or without cleft palate, contractures of the lower extremities, abnormal external genitalia, syndactyly of fingers and/or toes, and a pyramidal skin fold over the hallux nail. It has material basis in mutations in the IRF6 gene on chromosome 1.",false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,"An autosomal dominant disease characterized by abnormal development of the face, skin and genitals. Clinical expressions of the disease include cleft lip, with or without cleft palate, contractures of the lower extremities, abnormal external genitalia, syndactyly of fingers and/or toes, and a pyramidal skin fold over the hallux nail. It has material basis in mutations in the IRF6 gene on chromosome 1.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060055,emitraka,2015-02-04T14:16:39Z,,NCI:C118786|ORDO:1300|ORDO:294963|SNOMEDCT_US_2016_03_01:66783006|SNOMEDCT_US_2016_03_01:205820002|UMLS_CUI:C0265259|MESH:C562509|OMIM:263650|OMIM:119500,popliteal web syndrome|facio-genito-popliteal syndrome,,disease_ontology,,DOID:0060055,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,NT MGI.,,popliteal pterygium syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060050,"[""autoimmune disease of blood""]",,A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the blood.,false,,,http://purl.obolibrary.org/obo/DOID_417,,,,,,,,A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the blood.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060050,,,,,,,disease_ontology,,DOID:0060050,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,autoimmune disease of blood,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060053,"[""obsolete peripheral neuropathy""]",,A neuropathy that is located_in nerves of the peripheral nervous system.,[true],,,,,,,,,,,A neuropathy that is located_in nerves of the peripheral nervous system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060053,,,,,,,disease_ontology,,DOID:0060053,,,,,,,,,,,,,,,,,,,obsolete peripheral neuropathy,true,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000406,"[""THR796 in ERBB4""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000406,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR796 in ERBB4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200019,"[""CHRND gene""]",,"The acetylcholine receptor of muscle has 5 subunits of 4 different types: 2 alpha and 1 each of beta, gamma and delta subunits. After acetylcholine binding, the receptor undergoes an extensive conformation change that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in this gene are a cause of multiple pterygium syndrome lethal type (MUPSL), congenital myasthenic syndrome slow-channel type (SCCMS), and congenital myasthenic syndrome fast-channel type (FCCMS). Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Feb 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400503,,,,,,,,"The acetylcholine receptor of muscle has 5 subunits of 4 different types: 2 alpha and 1 each of beta, gamma and delta subunits. After acetylcholine binding, the receptor undergoes an extensive conformation change that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in this gene are a cause of multiple pterygium syndrome lethal type (MUPSL), congenital myasthenic syndrome slow-channel type (SCCMS), and congenital myasthenic syndrome fast-channel type (FCCMS). Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Feb 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200019,,,,,,,,,,,,,,,,1144,CHRND,ACHRD,,,,,,,,,,CHRND gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004185,"[""olfactory receptor neuron""]",,"Neurons in the olfactory epithelium with proteins that bind, and thus detect, odorants. Olfactory receptor neurons are bipolar. Unlike other neurons, they can be generated from precursor cells in adults.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001037,,,,,,,,"Neurons in the olfactory epithelium with proteins that bind, and thus detect, odorants. Olfactory receptor neurons are bipolar. Unlike other neurons, they can be generated from precursor cells in adults.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004185,,,,,,,BrendaTissueOBO,olfactory neuron|olfactory sensory neuron,BTO:0004185,,,,,,,,,,,,,,,,,,,olfactory receptor neuron,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004237,"[""myometrial cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004237,,,,,,,BrendaTissueOBO,uterine smooth muscle cell line,BTO:0004237,,,,,,,,,,,,,,,,,,,myometrial cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400410,"[""GRIA1 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400410,,,,,,,,,,,,,,,,,,,,,,,,,,,,GRIA1 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3491,"[""Turner syndrome""]",,"No OMIM mapping, confirmed by DO. [LS].",false,,,http://purl.obolibrary.org/obo/DOID_14447,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3491,,,DOID:5448,NCI:C34434|UMLS_CUI:C0041408|MESH:D014424|ICD10CM:Q96.9|ICD10CM:Q96.0|SNOMEDCT_US_2016_03_01:254279009|SNOMEDCT_US_2016_03_01:205691005|NCI:C26900|UMLS_CUI:C1527168|SNOMEDCT_US_2016_03_01:205685008|NCI:C85210|SNOMEDCT_US_2016_03_01:38804009|SNOMEDCT_US_2016_03_01:157020008|ICD10CM:Q96|SNOMEDCT_US_2016_03_01:268299006|SNOMEDCT_US_2016_03_01:268356004,"XO syndrome|Karyotype 45, X|Bonnevie-Ullrich syndrome|Gonadal dysgenesis - Turner|Monosomy X|monosomy X syndrome",,disease_ontology,,DOID:3491,,,,,,,,,,,,,,,,,"No OMIM mapping, confirmed by DO. [LS].",,Turner syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2513,"[""basal cell carcinoma""]",,A skin carcinoma affecting basal cells.,false,,,http://purl.obolibrary.org/obo/DOID_3451,,,,,,,,A skin carcinoma affecting basal cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2513,,,DOID:4276|DOID:4275,NCI:C3784|MESH:D002280|SNOMEDCT_US_2016_03_01:189574009|MESH:D018295|OMIM:613062|OMIM:614740|NCI:C2921|SNOMEDCT_US_2016_03_01:1338007|SNOMEDCT_US_2016_03_01:254701007|OMIM:613061|EFO:0004193|SNOMEDCT_US_2016_03_01:252995000|OMIM:613058|SNOMEDCT_US_2016_03_01:269582000|SNOMEDCT_US_2016_03_01:188083002|SNOMEDCT_US_2016_03_01:189572008|UMLS_CUI:C0206710|SNOMEDCT_US_2016_03_01:399049001|SNOMEDCT_US_2016_03_01:30649006|SNOMEDCT_US_2016_03_01:189573003|SNOMEDCT_US_2016_03_01:275265005|OMIM:605462|SNOMEDCT_US_2016_03_01:154507009|OMIM:613059|OMIM:613063|CSP:2000-2719|NCI:C7586|SNOMEDCT_US_2016_03_01:127570002|UMLS_CUI:C0007117|KEGG:05217|HP:0002671|UMLS_CUI:C1368295,Epithelioma basal cell (disorder)|Rodent ulcer|malignant basal cell tumor|BASAL CELL carcinoma OF SKIN|Basal cell cancer|Basal cell neoplasm (morphologic abnormality)|Basal cell carcinoma of skin (disorder)|malignant basal cell tumor (morphologic abnormality)|Basal cell tumor|Basal cell tumor (morphologic abnormality)|Basal cell carcinoma NOS (morphologic abnormality)|malignant Basal cell neoplasm|Basal cell neoplasm NOS (morphologic abnormality),,disease_ontology,,DOID:2513,,,,,,,,,,,,,,,,,Xref MGI.,,basal cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300513,"[""GABRB2 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300513,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRB2 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001056,"[""myeloid leukemia cell""]",,A malignant neoplasm of blood-forming tissues; marked by proliferation of myelocytes and their presence in the blood.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001271,,,,,,,,A malignant neoplasm of blood-forming tissues; marked by proliferation of myelocytes and their presence in the blood.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001056,,,,,,,BrendaTissueOBO,granulocytic leukemia cell|myelocytic leukemia cell,BTO:0001056,,,,,,,,,,,,,,,,,,,myeloid leukemia cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200404,"[""PDGFRB gene""]",,"This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400141,,,,,,,,"This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200404,,,,,,,,,,,,,,,,5159,PDGFRB,PDGFR|PDGFR1,,,,,,,,,,PDGFRB gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000021,"[""ILE642 in ERN1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30009,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000021,,,,,,,,,,,,,,,,,,,,,,,,,,,,ILE642 in ERN1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200224,"[""GRM7 gene""]",,"A metabotropic glutamate receptor 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14831] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400059,,,,,,,,"A metabotropic glutamate receptor 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14831] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200224,,,,,,,,,,,,,,,,2917,GRM7,GPRC1G|MGLUR7,,,,,,,,,,GRM7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200051,"[""CACNB4 gene""]",,"This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400334,,,,,,,,"This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200051,,,,,,,,,,,,,,,,785,CACNB4,CACNLB4,,,,,,,,,,CACNB4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491032,"[""Carbohydrate kinase PfkB family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400325,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491032,,,,,,,,,,,,,,,,,,,,,,,,,,,,Carbohydrate kinase PfkB family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100258,"[""Glutamate receptor ionotropic, nmda 2b""]",,"A glutamate receptor ionotropic, NMDA 2B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13224] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300456,,,,,,,,"A glutamate receptor ionotropic, NMDA 2B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13224] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100258,,,,https://pharos.nih.gov/idg/targets/Q13224,,,,,,,,,,,,,GRIN2B,NMDAR2B,,Q13224,,,,,,,,"Glutamate receptor ionotropic, nmda 2b",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300423,"[""KCNJ12 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300423,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ12 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200218,"[""CAMK2A gene""]",,"The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400172,,,,,,,,"The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200218,,,,,,,,,,,,,,,,815,CAMK2A,CAMKA|KIAA0968,,,,,,,,,,CAMK2A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100174,"[""Kv channel-interacting protein 4""]",,"A Kv channel-interacting protein 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6PIL6] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300357,,,,,,,,"A Kv channel-interacting protein 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6PIL6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100174,,,,https://pharos.nih.gov/idg/targets/Q6PIL6,,,,,,,,,,,,,KCNIP4,CALP|KCHIP4,,Q6PIL6,,,,,,,,Kv channel-interacting protein 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100327,"[""Olfactory receptor 10z1""]",,"An olfactory receptor 10Z1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10Z1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100327,,,,https://pharos.nih.gov/idg/targets/Q8NGY1,,,,,,,,,,,,,OR10Z1,,,Q8NGY1,,,,,,,,Olfactory receptor 10z1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117463,"[""Rev-erb receptors""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00102000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117463,,,,,,,,,,,,,,,,,,,,,,,,,,,,Rev-erb receptors,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300167,"[""JAKA family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300167,,,,,,,,,,,,,,,,,,,,,,,,,,,,JAKA family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300335,"[""Calcium homeostasis modulator calcium channel (calhm-c) family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300335,,,,,,,,,,,,,,,,,,,,,,,,,,,,Calcium homeostasis modulator calcium channel (calhm-c) family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3153,"[""lipomatosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_37,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3153,,,,ICD10CM:E88.2|MESH:D008068|SNOMEDCT_US_2016_03_01:37095002|UMLS_CUI:C0023801|SNOMEDCT_US_2016_03_01:402693001,,,disease_ontology,,DOID:3153,,,,,,,,,,,,,,,,,,,lipomatosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000293,"[""occipital lobe""]",,This lobe is located at the back of the head and is involved in vision and reading.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,This lobe is located at the back of the head and is involved in vision and reading.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000293,,,,,,,BrendaTissueOBO,occipital cortex,BTO:0000293,,,,,,,,,,,,,,,,,,,occipital lobe,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200209,"[""KCNH5 gene""]",,"This gene encodes a member of voltage-gated potassium channels. Members of this family have diverse functions, including regulating neurotransmitter and hormone release, cardiac function, and cell volume. This protein is an outward-rectifying, noninactivating channel. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_01400557,,,,,,,,"This gene encodes a member of voltage-gated potassium channels. Members of this family have diverse functions, including regulating neurotransmitter and hormone release, cardiac function, and cell volume. This protein is an outward-rectifying, noninactivating channel. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200209,,,,,,,,,,,,,,,,27133,KCNH5,EAG2,,,,,,,,,,KCNH5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005033,"[""MV3 cell""]",,Highly tumorigenic and metastatic human melanoma cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0000849|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Highly tumorigenic and metastatic human melanoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005033,XPMUser,2012-08-31T03:43:15Z,,,,,BrendaTissueOBO,,BTO:0005033,,,,,,,,,,,,,,,,,,,MV3 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200587,"[""OR4F4 gene""]",,"An olfactory receptor 4F4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R69] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4F4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R69] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200587,,,,,,,,,,,,,,,,26682,OR4F4,,,,,,,,,,,OR4F4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200690,"[""OR8B12 gene""]",,"An olfactory receptor 8B12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 8B12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200690,,,,,,,,,,,,,,,,219858,OR8B12,,,,,,,,,,,OR8B12 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200311,"[""OR10H5 gene""]",,"An olfactory receptor 10H5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10H5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200311,,,,,,,,,,,,,,,,284433,OR10H5,,,,,,,,,,,OR10H5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000436,"[""TLK1 kinase domain""]",,Serine/threonine-protein kinase tousled-like 1; tousled-like kinase 1; KIAA0137; PKU-beta; TLK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase tousled-like 1; tousled-like kinase 1; KIAA0137; PKU-beta; TLK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000436,,,,,,,,,,,,,,,,,,,200437,,,,,,,,,TLK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200744,"[""PTGER2 gene""]",,"A prostaglandin E2 receptor EP2 subtype that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43116] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A prostaglandin E2 receptor EP2 subtype that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43116] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200744,,,,,,,,,,,,,,,,5732,PTGER2,,,,,,,,,,,PTGER2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200628,"[""OR5I1 gene""]",,"An olfactory receptor 5I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13606] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13606] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200628,,,,,,,,,,,,,,,,10798,OR5I1,OLF1,,,,,,,,,,OR5I1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100138,"[""Glutamate receptor ionotropic, delta-2""]",,"A glutamate receptor ionotropic, delta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43424] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300415,,,,,,,,"A glutamate receptor ionotropic, delta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43424] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100138,,,,https://pharos.nih.gov/idg/targets/O43424,,,,,,,,,,,,,GRID2,GLURD2,,O43424,,,,,,,,"Glutamate receptor ionotropic, delta-2",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060038,"[""specific developmental disorder""]",,A developmental disorder of mental health that categorizes specific learning disabilities and developmental disorders affecting coordination.,false,,,http://purl.obolibrary.org/obo/DOID_0060037,,,,,,,,A developmental disorder of mental health that categorizes specific learning disabilities and developmental disorders affecting coordination.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060038,,,,,,,disease_ontology,,DOID:0060038,,,,,,,,,,,,,,,,,,,specific developmental disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060033,"[""autoimmune disease of peripheral nervous system""]",,An autoimmune disease of the nervous system that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the peripheral nervous system.,false,,,http://purl.obolibrary.org/obo/DOID_438|http://purl.obolibrary.org/obo/DOID_574,,,,,,,,An autoimmune disease of the nervous system that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the peripheral nervous system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060033,,,,,,,disease_ontology,,DOID:0060033,,,,,,,,,,,,,,,,,,,autoimmune disease of peripheral nervous system,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060036,"[""intrinsic cardiomyopathy""]",,A cardiomyopathy that is characterized as weakness in the muscle of the heart that is not due to an identifiable external cause.,false,,,http://purl.obolibrary.org/obo/DOID_0050700,,,,,,,,A cardiomyopathy that is characterized as weakness in the muscle of the heart that is not due to an identifiable external cause.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060036,,,,,,,disease_ontology,,DOID:0060036,,,,,,,,,,,,,,,,,,,intrinsic cardiomyopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060031,"[""autoimmune disease of gastrointestinal tract""]",,A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the gastrointestinal tract.,false,,,http://purl.obolibrary.org/obo/DOID_417,,,,,,,,A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the gastrointestinal tract.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060031,,,,,,,disease_ontology,,DOID:0060031,,,,,,,,,,,,,,,,,,,autoimmune disease of gastrointestinal tract,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060032,"[""autoimmune disease of musculoskeletal system""]",,An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the musculoskeletal system.,false,,,http://purl.obolibrary.org/obo/DOID_417|http://purl.obolibrary.org/obo/DOID_17,,,,,,,,An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the musculoskeletal system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060032,,,,,,,disease_ontology,,DOID:0060032,,,,,,,,,,,,,,,,,,,autoimmune disease of musculoskeletal system,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060037,"[""developmental disorder of mental health""]",,A disease of mental health that occur during a child's developmental period between birth and age 18 resulting in retarding of the child's psychological or physical development.,false,,,http://purl.obolibrary.org/obo/DOID_150,,,,,,,,A disease of mental health that occur during a child's developmental period between birth and age 18 resulting in retarding of the child's psychological or physical development.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060037,,,,,,,disease_ontology,,DOID:0060037,,,,,,,,,,,,,,,,,,,developmental disorder of mental health,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003233,"[""FaDu cell""]",,Human squamous cell carcinoma cell line of the hypopharynx.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0004546,,,,,,,,Human squamous cell carcinoma cell line of the hypopharynx.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003233,,,,,,,BrendaTissueOBO,,BTO:0003233,,,,,,,,,,,,,,,,,,,FaDu cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000668,"[""kernel""]",,"The inner softer part of a seed, fruit stone, or nut.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The inner softer part of a seed, fruit stone, or nut.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000668,,,,,,,BrendaTissueOBO,,BTO:0000668,,,,,,,,,,,,,,,,,,,kernel,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003001,"[""EBC-1 cell""]",,Human lung squamous cell carcinoma cell line; established from a 68 year old male.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002202,,,,,,,,Human lung squamous cell carcinoma cell line; established from a 68 year old male.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003001,,,,,,,BrendaTissueOBO,EBC1 cell,BTO:0003001,,,,,,,,,,,,,,,,,,,EBC-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003101,"[""female pudendum""]",,"That portion of the female genitalia comprising the mons pubis, labia majora, labia minora, vestibule of the vagina, bulb of the vestibule, greater and lesser vestibular glands, and vaginal orifice. Commonly used to denote the entire external female genitalia.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062|http://purl.obolibrary.org/obo/BTO_0003100,,,,,,,,"That portion of the female genitalia comprising the mons pubis, labia majora, labia minora, vestibule of the vagina, bulb of the vestibule, greater and lesser vestibular glands, and vaginal orifice. Commonly used to denote the entire external female genitalia.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003101,,,,,,,BrendaTissueOBO,puboperineal region|pudendum muliebre|pudendum|pudendum femininum|vulva,BTO:0003101,,,,,,,,,,,,,,,,,,,female pudendum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400165,"[""MLK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400107,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400165,,,,,,,,,,,,,,,,,,,,,,,,,,,,MLK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000115,"[""MET129 in MP2K6""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000115,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET129 in MP2K6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000229,"[""MET95 in YSK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000229,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET95 in YSK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100002,"[""A545 in PIK3CA(E545A)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100002,,,,,,,,,,,,,,,,,,,,,,,,,,,,A545 in PIK3CA(E545A),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000060,"[""PGE1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000060,,,,,,,,,,,,,,,,,,,,,,,,,,,,PGE1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391023,"[""Thiamine pyrophosphokinase family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300324,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391023,,,,,,,,,,,,,,,,,,,,,,,,,,,,Thiamine pyrophosphokinase family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100332,"[""Olfactory receptor 11H4""]",,"An olfactory receptor 11H4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 11H4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100332,,,,https://pharos.nih.gov/idg/targets/Q8NGC9,,,,,,,,,,,,,OR11H4,,,Q8NGC9,,,,,,,,Olfactory receptor 11H4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200461,"[""ROS1 gene""]",,"This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400220,,,,,,,,"This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200461,,,,,,,,,,,,,,,,6098,ROS1,MCF3|ROS,,,,,,,,,,ROS1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005425,"[""NCI-H2170 cell""]",,Human lung squamous cell carcinoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002202,,,,,,,,Human lung squamous cell carcinoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005425,XPMUser,2013-03-15T06:48:39Z,,,,,BrendaTissueOBO,H2170 cell,BTO:0005425,,,,,,,,,,,,,,,,,,,NCI-H2170 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000111,"[""DDR1 kinase domain""]",,Discoidin domain receptor tyrosine kinase 1; CAK; CD167; DDR; DDR1; EDDR1; HGK2; MCK10; NEP; NTRK4; PTK3; PTK3A; RTK6; TRKE,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Discoidin domain receptor tyrosine kinase 1; CAK; CD167; DDR; DDR1; EDDR1; HGK2; MCK10; NEP; NTRK4; PTK3; PTK3A; RTK6; TRKE,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000111,,,,,,,,,,,,,,,,,,,200112,,,,,,,,,DDR1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100380,"[""Olfactory receptor 4C46""]",,"An olfactory receptor 4C46 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NHA9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4C46 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NHA9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100380,,,,https://pharos.nih.gov/idg/targets/A6NHA9,,,,,,,,,,,,,OR4C46,,,A6NHA9,,,,,,,,Olfactory receptor 4C46,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100376,"[""Olfactory receptor 4A15""]",,"An olfactory receptor 4A15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4A15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100376,,,,https://pharos.nih.gov/idg/targets/Q8NGL6,,,,,,,,,,,,,OR4A15,,,Q8NGL6,,,,,,,,Olfactory receptor 4A15,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200652,"[""OR6B2 gene""]",,"An olfactory receptor 6B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IFH4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IFH4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200652,,,,,,,,,,,,,,,,389090,OR6B2,OR6B2P,,,,,,,,,,OR6B2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000843,"[""megakaryocyte""]",,"A large cell that has a lobulated nucleus, is found especially in the bone marrow, and is the source of blood platelets.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001441,,,,,,,,"A large cell that has a lobulated nucleus, is found especially in the bone marrow, and is the source of blood platelets.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000843,,,,,,,BrendaTissueOBO,megacaryocyte|megalokaryocyte|megalocaryocyte,BTO:0000843,,,,,,,,,,,,,,,,,,,megakaryocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200751,"[""PRLHR gene""]",,"A prolactin-releasing peptide receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49683] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A prolactin-releasing peptide receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49683] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200751,,,,,,,,,,,,,,,,2834,PRLHR,GPR10|GR3,,,,,,,,,,PRLHR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400226,"[""SRPK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400111,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400226,,,,,,,,,,,,,,,,,,,,,,,,,,,,SRPK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200010,"[""CHRNA5 gene""]",,"The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400494,,,,,,,,"The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200010,,,,,,,,,,,,,,,,1138,CHRNA5,NACHRA5,,,,,,,,,,CHRNA5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005332,"[""RWLeu-4 cell""]",,RWLeu4 is a chronic myelogenous leukemia cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002580,,,,,,,,RWLeu4 is a chronic myelogenous leukemia cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005332,XPMUser,2012-03-21T10:48:49Z,,,,,BrendaTissueOBO,RWLeu4 cell,BTO:0005332,,,,,,,,,,,,,,,,,,,RWLeu-4 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300586,"[""TRPM4 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300483,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300586,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPM4 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100200,"[""Probable G-protein coupled receptor 52""]",,"A G-protein coupled receptor 52 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y2T5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300053,,,,,,,,"A G-protein coupled receptor 52 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y2T5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100200,,,,https://pharos.nih.gov/idg/targets/Q9Y2T5,,,,,,,,,,,,,GPR52,,,Q9Y2T5,,,,,,,,Probable G-protein coupled receptor 52,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200133,"[""EPHA10 gene""]",,"Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400153,,,,,,,,"Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200133,,,,,,,,,,,,,,,,284656,EPHA10,,,,,,,,,,,EPHA10 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12336,"[""male infertility""]",,,false,,,http://purl.obolibrary.org/obo/DOID_48,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12336,,,,SNOMEDCT_US_2016_03_01:155924001|MESH:D007248|UMLS_CUI:C0021364|ICD9CM:606.9|ICD9CM:606|ICD10CM:N46|ICD10CM:N46.9|SNOMEDCT_US_2016_03_01:198018002|SNOMEDCT_US_2016_03_01:2904007,,,disease_ontology,,DOID:12336,,,,,,,,,,,,,,,,,,,male infertility,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100044,"[""Q663 in FLT3(K663Q)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100044,,,,,,,,,,,,,,,,,,,,,,,,,,,,Q663 in FLT3(K663Q),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100555,"[""Olfactory receptor 2w1""]",,"An olfactory receptor 2W1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y3N9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2W1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y3N9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100555,,,,https://pharos.nih.gov/idg/targets/Q9Y3N9,,,,,,,,,,,,,OR2W1,,,Q9Y3N9,,,,,,,,Olfactory receptor 2w1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02402010,"[""VN1R17P gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400016,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02402010,,,,,,,,,,,,,,,,,VN1R17P,,,,,,,,,,,VN1R17P gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_34146,"[""12(S)-HETE""]","12(S)-hydroxy-5,8,14(Z),10(E)-eicosatetraenoic acid|(5Z,8Z,10E,12S,14Z)-12-hydroxyeicosa-5,8,10,14-tetraenoic acid|InChI=1S/C20H32O3/c1-2-3-4-5-10-13-16-19(21)17-14-11-8-6-7-9-12-15-18-20(22)23/h7-11,13-14,17,19,21H,2-6,12,15-16,18H2,1H3,(H,22,23)/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1|320.46628|320.235|12S-HETE|(12S)-12-hydroxy-5,8,14-cis-10-trans-eicosatetraenoic acid|12(S)-hydroxyeicosatetraenoic acid|ZNHVWPKMFKADKW-LQWMCKPYSA-N|(5Z,8Z,10E,14Z)-(12S)-12-Hydroxyicosa-5,8,10,14-tetraenoic acid|12(S)-hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic acid|0|CCCCC\C=C/C[C@H](O)\C=C\C=C/C\C=C/CCCC(O)=O|(5Z,8Z,10E,14Z)-(12S)-12-Hydroxyeicosa-5,8,10,14-tetraenoic acid|C20H32O3","A HETE having a (12S)-hydroxy group and (5Z)-, (8Z)-, (10E)- and (14Z)-double bonds.",false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,PMID:11158968|PMID:7683691|PMID:11756509|CAS:54397-83-0|PMID:17963719|PMID:7540838|Reaxys:2656104|PMID:12697425|PMID:3026490|PMID:15105833|PMID:7492988|PMID:25449650|Beilstein:2656104|PMID:7511046|PMID:7688315|PMID:10952974|LIPID_MAPS_instance:LMFA03060007|PMID:7593207|KNApSAcK:C00000424|PMID:2517876|PMID:11726629|KEGG:C14777,"A HETE having a (12S)-hydroxy group and (5Z)-, (8Z)-, (10E)- and (14Z)-double bonds.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,"(5Z,8Z,10E,12S,14Z)-12-hydroxyicosa-5,8,10,14-tetraenoic acid|12(S)-HETE",,chebi_ontology,"12(S)-hydroxy-5,8,14(Z),10(E)-eicosatetraenoic acid|(5Z,8Z,10E,12S,14Z)-12-hydroxyeicosa-5,8,10,14-tetraenoic acid|InChI=1S/C20H32O3/c1-2-3-4-5-10-13-16-19(21)17-14-11-8-6-7-9-12-15-18-20(22)23/h7-11,13-14,17,19,21H,2-6,12,15-16,18H2,1H3,(H,22,23)/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1|320.46628|320.235|12S-HETE|(12S)-12-hydroxy-5,8,14-cis-10-trans-eicosatetraenoic acid|12(S)-hydroxyeicosatetraenoic acid|ZNHVWPKMFKADKW-LQWMCKPYSA-N|(5Z,8Z,10E,14Z)-(12S)-12-Hydroxyicosa-5,8,10,14-tetraenoic acid|12(S)-hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic acid|0|CCCCC\C=C/C[C@H](O)\C=C\C=C/C\C=C/CCCC(O)=O|(5Z,8Z,10E,14Z)-(12S)-12-Hydroxyeicosa-5,8,10,14-tetraenoic acid|C20H32O3",,,CHEBI:34146,,,,,,,,,,,,,,,,,,,,,,,CHEBI:34146,,,,,12(S)-HETE,,CHEBI:34146,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10471,"[""patellar tendinitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_971,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10471,,,,ICD10CM:M76.50|ICD10CM:M76.5|SNOMEDCT_US_2016_03_01:268089006|ICD9CM:726.64|UMLS_CUI:C0158317|SNOMEDCT_US_2016_03_01:156662006|SNOMEDCT_US_2016_03_01:37785001,Patellar tendonitis (disorder),,disease_ontology,,DOID:10471,,,,,,,,,,,,,,,,,,,patellar tendinitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001573,"[""brain cancer cell""]",,"Cancer cell of the central information processing center of the body. Tumors in the brain can be malignant or benign, and can occur at any age. Only malignant tumors are cancerous. Primary brain tumors cancer initially forms in the brain tissue. Secondary brain tumors cancers are cancers that have spread to the brain tissue (metastasized) from elsewhere in the body. Secondary brain cancer is named for the organ or tissue in which the cancer begins, such as lung cancer with secondary brain metastasis.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Cancer cell of the central information processing center of the body. Tumors in the brain can be malignant or benign, and can occur at any age. Only malignant tumors are cancerous. Primary brain tumors cancer initially forms in the brain tissue. Secondary brain tumors cancers are cancers that have spread to the brain tissue (metastasized) from elsewhere in the body. Secondary brain cancer is named for the organ or tissue in which the cancer begins, such as lung cancer with secondary brain metastasis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001573,,,,,,,BrendaTissueOBO,brain tumor cell|intracranial tumor cell,BTO:0001573,,,,,,,,,,,,,,,,,,,brain cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000185,"[""CXCL8""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000185,,,,,,,,,,,,,,,,,,,,,,,,,,,,CXCL8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200126,"[""GLRA1 gene""]",,"The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor. The receptor mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_01400525,,,,,,,,"The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor. The receptor mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200126,,,,,,,,,,,,,,,,2741,GLRA1,,,,,,,,,,,GLRA1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000632,"[""insulinoma cell""]",,A cell of a usually benign tumor of the insulin-secreting cells of the pancreas.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000584,,,,,,,,A cell of a usually benign tumor of the insulin-secreting cells of the pancreas.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000632,,,,,,,BrendaTissueOBO,,BTO:0000632,,,,,,,,,,,,,,,,,,,insulinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400453,"[""NR3A/GRIN3A subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400453,,,,,,,,,,,,,,,,,,,,,,,,,,,,NR3A/GRIN3A subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4037,"[""necrotizing gastritis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4029,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4037,,,,NCI:C27329|UMLS_CUI:C0877152,,,disease_ontology,,DOID:4037,,,,,,,,,,,,,,,,,,,necrotizing gastritis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000426,"[""TAOK1 kinase domain""]",,Serine/threonine-protein kinase TAO1; prostate-derived STE20-like kinase 2; hKFC-B; FLJ14314; KIAA1361; MAP3K16; MARKK; PSK2; TAO1; TAOK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase TAO1; prostate-derived STE20-like kinase 2; hKFC-B; FLJ14314; KIAA1361; MAP3K16; MARKK; PSK2; TAO1; TAOK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000426,,,,,,,,,,,,,,,,,,,200427,,,,,,,,,TAOK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12557,"[""Duane retraction syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_540,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12557,,,,UMLS_CUI:C0013261|MESH:D004370|SNOMEDCT_US_2016_03_01:60318001|NCI:C84678|ICD9CM:378.71|OMIM:604356|ICD10CM:H50.81|OMIM:126800,Duane's syndrome|Stilling-Turk-Duane syndrome,,disease_ontology,,DOID:12557,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Duane retraction syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12558,"[""chronic progressive external ophthalmoplegia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_699,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12558,,,,SNOMEDCT_US_2016_03_01:194034008|ICD9CM:378.72|UMLS_CUI:C0162674|ICD10CM:H49.4|SNOMEDCT_US_2016_03_01:194126004|SNOMEDCT_US_2016_03_01:46252003|MESH:D017246,progressive external ophthalmoplegia|chronic progressive external ophthalmoplegia [Ambiguous]|progressive external ophthalmoplegia (disorder),,disease_ontology,,DOID:12558,,,,,,,,,,,,,,,,,,,chronic progressive external ophthalmoplegia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000124,"[""MET140 in HUNK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000124,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET140 in HUNK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3605,"[""ovarian cystadenocarcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3713,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3605,,,,SNOMEDCT_US_2016_03_01:314191009|UMLS_CUI:C1096638|NCI:C5228,cystadenocarcinoma of the Ovary|cystadenocarcinoma of ovary (disorder),,disease_ontology,,DOID:3605,,,,,,,,,,,,,,,,,,,ovarian cystadenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200532,"[""OR2J3 gene""]",,"An olfactory receptor 2J3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76001] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2J3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76001] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200532,,,,,,,,,,,,,,,,442186,OR2J3,,,,,,,,,,,OR2J3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100596,"[""UMP-CMP kinase""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100596,,,,,,,,,,,,,,,,,CMPK1,,,P30085,,,,,,,,UMP-CMP kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200207,"[""CSNK1A1L gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400170,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200207,,,,,,,,,,,,,,,,122011,CSNK1A1L,,,,,,,,,,,CSNK1A1L gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100268,"[""Lim domain kinase 2""]",,"A LIM domain kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P53671] |LIM domain kinase 2 (LIMK2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300283,,,,,,,,"A LIM domain kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P53671] |LIM domain kinase 2 (LIMK2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100268,,,,https://pharos.nih.gov/idg/targets/P53671,,,,,,,,,,,,,LIMK2,,,P53671,,,,,,,,Lim domain kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200543,"[""OR2M7 gene""]",,"An olfactory receptor 2M7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG81] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2M7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG81] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200543,,,,,,,,,,,,,,,,391196,OR2M7,,,,,,,,,,,OR2M7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000219,"[""CCL26""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000219,,,,,,,,,,,,,,,,,,,,,,,,,,,,CCL26,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80261,"[""Alpha-Neoendorphin""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG COMPOUND:C16039,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80261,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80261,,,,,alpha-Neoendorphin|Alpha-Neoendorphin,,CHEBI:80261,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200322,"[""OR10S1 gene""]",,"An olfactory receptor 10S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200322,,,,,,,,,,,,,,,,219873,OR10S1,,,,,,,,,,,OR10S1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100558,"[""Serine/threonine-protein kinase ulk4""]",,"A serine/threonine-protein kinase ULK4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96C45] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300228,,,,,,,,"A serine/threonine-protein kinase ULK4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96C45] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100558,,,,https://pharos.nih.gov/idg/targets/Q96C45,,,,,,,,,,,,,ULK4,,,Q96C45,,,,,,,,Serine/threonine-protein kinase ulk4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100197,"[""Potassium voltage-gated channel subfamily e member 2""]",,"A potassium voltage-gated channel subfamily E member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y6J6] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300445,,,,,,,,"A potassium voltage-gated channel subfamily E member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y6J6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100197,,,,https://pharos.nih.gov/idg/targets/Q9Y6J6,,,,,,,,,,,,,KCNE2,,,Q9Y6J6,,,,,,,,Potassium voltage-gated channel subfamily e member 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002272,"[""merozoite""]",,A protozoan cell that arises from the schizogony of a parent sporozoan and may enter either the asexual or sexual phase of the life cycle.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000749,,,,,,,,A protozoan cell that arises from the schizogony of a parent sporozoan and may enter either the asexual or sexual phase of the life cycle.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002272,,,,,,,BrendaTissueOBO,,BTO:0002272,,,,,,,,,,,,,,,,,,,merozoite,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200090,"[""CSF1R gene""]",,"The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400141,,,,,,,,"The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200090,,,,,,,,,,,,,,,,1436,CSF1R,FMS,,,,,,,,,,CSF1R gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200093,"[""GPR37L1 gene""]",,"A prosaposin receptor GPR37L1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O60883] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400038,,,,,,,,"A prosaposin receptor GPR37L1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O60883] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200093,,,,,,,,,,,,,,,,9283,GPR37L1,ETBRLP2,,,,,,,,,,GPR37L1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400427,"[""KCNJ16 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400427,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ16 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117470,"[""Tailless-like receptors""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00102000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117470,,,,,,,,,,,,,,,,,,,,,,,,,,,,Tailless-like receptors,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200319,"[""OR10P1 gene""]",,"An olfactory receptor 10P1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10P1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200319,,,,,,,,,,,,,,,,121130,OR10P1,OR10P1P|OR10P2P|OR10P3P,,,,,,,,,,OR10P1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300368,"[""SLC26A/SulP transporter family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300368,,,,,,,,,,,,,,,,,,,,,,,,,,,,SLC26A/SulP transporter family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200101,"[""DCK gene""]",," Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs.  Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents.  Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives.  DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03491008,,,,,,,," Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs.  Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents.  Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives.  DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200101,,,,,,,,,,,,,,,,1633,DCK,,,,,,,,,,,DCK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001335,"[""syncytiotrophoblast""]",,Syncytial layer that forms the outermost fetal layer in the placenta and is thus the interface with maternal tissue. Has invasive capacity - though in a regulated manner.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Syncytial layer that forms the outermost fetal layer in the placenta and is thus the interface with maternal tissue. Has invasive capacity - though in a regulated manner.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001335,,,,,,,BrendaTissueOBO,syncytial trophoblast,BTO:0001335,,,,,,,,,,,,,,,,,,,syncytiotrophoblast,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001547,"[""sepal""]",,One of the modified leaves comprising a calyx.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,One of the modified leaves comprising a calyx.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001547,,,,,,,BrendaTissueOBO,,BTO:0001547,,,,,,,,,,,,,,,,,,,sepal,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300476,"[""Nav1.9/SCN11A subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300369,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300476,,,,,,,,,,,,,,,,,,,,,,,,,,,,Nav1.9/SCN11A subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000242,"[""LYN kinase domain""]",,V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; FLJ26625; JTK8; LYN,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; FLJ26625; JTK8; LYN,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000242,,,,,,,,,,,,,,,,,,,200232,,,,,,,,,LYN kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001600,"[""cuticle""]",,A layer of more or less solid substance which covers the free surface of an epithelial cell.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000634,,,,,,,,A layer of more or less solid substance which covers the free surface of an epithelial cell.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001600,,,,,,,BrendaTissueOBO,cuticula,BTO:0001600,,,,,,,,,,,,,,,,,,,cuticle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80319,"[""Orexin A""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16105|CAS:205599-75-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80319,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80319,,,,,Orexin A,,CHEBI:80319,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200084,"[""DRD4 gene""]",,"A D(4) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21917] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400037,,,,,,,,"A D(4) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21917] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200084,,,,,,,,,,,,,,,,1815,DRD4,,,,,,,,,,,DRD4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100262,"[""Nadph oxidase 1""]",,"An NADPH oxidase 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5S8] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300346,,,,,,,,"An NADPH oxidase 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5S8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100262,,,,https://pharos.nih.gov/idg/targets/Q9Y5S8,,,,,,,,,,,,,NOX1,MOX1|NOH1,,Q9Y5S8,,,,,,,,Nadph oxidase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200533,"[""OR2K2 gene""]",,"An olfactory receptor 2K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200533,,,,,,,,,,,,,,,,26248,OR2K2,OR2AR1P,,,,,,,,,,OR2K2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200387,"[""PAK4 gene""]",,"PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400304,,,,,,,,"PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200387,,,,,,,,,,,,,,,,10298,PAK4,KIAA1142,,,,,,,,,,PAK4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001521,"[""pancreatic adenocarcinoma cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0000167|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000794,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001521,,,,,,,BrendaTissueOBO,,BTO:0001521,,,,,,,,,,,,,,,,,,,pancreatic adenocarcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003927,"[""metacercaria""]",,A tailless encysted late larva of a trematode parasite that is usually the form which is infective for the definitive host.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000707,,,,,,,,A tailless encysted late larva of a trematode parasite that is usually the form which is infective for the definitive host.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003927,,,,,,,BrendaTissueOBO,,BTO:0003927,,,,,,,,,,,,,,,,,,,metacercaria,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000037,"[""AKT3 kinase domain""]",,"V-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma); AKT3; Akt3/PKBg; DKFZp434N0250; PKBg; PKB-GAMMA; PRKBG; RAC-gamma; RAC-PK-gamma; STK-2",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"V-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma); AKT3; Akt3/PKBg; DKFZp434N0250; PKBg; PKB-GAMMA; PRKBG; RAC-gamma; RAC-PK-gamma; STK-2",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000037,,,,,,,,,,,,,,,,,,,200036,,,,,,,,,AKT3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200660,"[""OR6J1 gene""]",,"An olfactory receptor 6J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200660,,,,,,,,,,,,,,,,79549,OR6J1,OR6J2,,,,,,,,,,OR6J1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100248,"[""Leukotriene b4 receptor 1""]",,"A leukotriene B4 receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15722] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300033,,,,,,,,"A leukotriene B4 receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15722] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100248,,,,https://pharos.nih.gov/idg/targets/Q15722,,,,,,,,,,,,,LTB4R,BLT|BLT1|BLTR|CMKRL1|GPR16|P2RY7,,Q15722,,,,,,,,Leukotriene b4 receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004547,"[""hypopharyngeal squamous cell carcinoma cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001289,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004547,mgr,2010-02-16T11:05:49Z,,,,,BrendaTissueOBO,,BTO:0004547,,,,,,,,,,,,,,,,,,,hypopharyngeal squamous cell carcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217529,"[""NR0B2 gene""]",,"The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_00217459,,,,,,,,"The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217529,,,,,,,,,,,,,,,,8431,NR0B2,SHP,,,,,,,,,,NR0B2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400194,"[""STE7 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400113,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400194,,,,,,,,,,,,,,,,,,,,,,,,,,,,STE7 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005089,"[""perichondrium""]",,"A dense membrane composed of fibrous connective tissue that closely wraps (invests) all cartilage, except the cartilage in joints which is covered by a synovial membrane.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A dense membrane composed of fibrous connective tissue that closely wraps (invests) all cartilage, except the cartilage in joints which is covered by a synovial membrane.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005089,XPMUser,2011-03-08T09:08:36Z,,,,,BrendaTissueOBO,,BTO:0005089,,,,,,,,,,,,,,,,,,,perichondrium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001522,"[""B-lymphocyte cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001522,,,,,,,BrendaTissueOBO,B-cell line,BTO:0001522,,,,,,,,,,,,,,,,,,,B-lymphocyte cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400023,"[""Angiotensin receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400023,,,,,,,,,,,,,,,,,,,,,,,,,,,,Angiotensin receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300420,"[""GRIK5 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300420,,,,,,,,,,,,,,,,,,,,,,,,,,,,GRIK5 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001539,"[""parenchyma""]",,"The tissue characteristic of an organ, as distinguished from associated connective or supporting tissues.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The tissue characteristic of an organ, as distinguished from associated connective or supporting tissues.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001539,Marion,2013-11-07T09:33:34Z,,,,,BrendaTissueOBO,,BTO:0001539,,,,,,,,,,,,,,,,,,,parenchyma,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14503,"[""neuronal ceroid lipofuscinosis""]",,"Xref MGI.
OMIM mapping submitted by NeuroDevNet. [LS].",false,,,http://purl.obolibrary.org/obo/DOID_9455,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14503,,,,NCI:C61257|UMLS_CUI:C0027877|ORDO:79262|SNOMEDCT_US_2016_03_01:42012007|OMIM:PS256730|ICD10CM:E75.4|MESH:D009472|ORDO:216,hereditary ceroid lipofuscinosis,,disease_ontology,,DOID:14503,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping submitted by NeuroDevNet. [LS].",,neuronal ceroid lipofuscinosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002410,"[""giant cell carcinoma cell""]",,"A poorly differentiated, highly malignant, epithelial neoplasm containing numerous very large, multinucleated tumor cells, such as occurs in the lungs.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000176,,,,,,,,"A poorly differentiated, highly malignant, epithelial neoplasm containing numerous very large, multinucleated tumor cells, such as occurs in the lungs.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002410,,,,,,,BrendaTissueOBO,,BTO:0002410,,,,,,,,,,,,,,,,,,,giant cell carcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200057,"[""CACNG3 gene""]",,"The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for childhood absence epilepsy. [provided by RefSeq, Dec 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400336,,,,,,,,"The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for childhood absence epilepsy. [provided by RefSeq, Dec 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200057,,,,,,,,,,,,,,,,10368,CACNG3,,,,,,,,,,,CACNG3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100338,"[""Olfactory receptor 12D3""]",,"An olfactory receptor 12D3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UGF7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 12D3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UGF7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100338,,,,https://pharos.nih.gov/idg/targets/Q9UGF7,,,,,,,,,,,,,OR12D3,,,Q9UGF7,,,,,,,,Olfactory receptor 12D3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000253,"[""PHE240 in CDK16""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000253,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE240 in CDK16,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200827,"[""OR13C6P gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200827,,,,,,,,,,,,,,,,392311,OR13C6P,,,,,,,,,,,OR13C6P gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000116,"[""DRAK2 kinase domain""]",,Serine/threonine kinase 17b; DRAK2; STK17B,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine kinase 17b; DRAK2; STK17B,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000116,,,,,,,,,,,,,,,,,,,200118,,,,,,,,,DRAK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003676,"[""lymphoblastic leukemia cell""]",,Lymphocytic leukemia characterized by an abnormal increase in the number of lymphoblasts.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000744,,,,,,,,Lymphocytic leukemia characterized by an abnormal increase in the number of lymphoblasts.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003676,,,,,,,BrendaTissueOBO,,BTO:0003676,,,,,,,,,,,,,,,,,,,lymphoblastic leukemia cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200329,"[""OR11G2 gene""]",,"An olfactory receptor 11G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 11G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200329,,,,,,,,,,,,,,,,390439,OR11G2,,,,,,,,,,,OR11G2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_24636,"[""proton""]",,"Nuclear particle of charge number +1, spin 1/2 and rest mass of 1.007276470(12) u.",false,,,http://purl.obolibrary.org/obo/CHEBI_36916,,,,,,,,"Nuclear particle of charge number +1, spin 1/2 and rest mass of 1.007276470(12) u.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:24636,,,,,proton,,CHEBI:24636,,,http://purl.obolibrary.org/obo/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4961,"[""bone marrow disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_74,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4961,,,,SNOMEDCT_US_2016_03_01:127035006|UMLS_CUI:C0005956|MESH:D001855|NCI:C34433,bone marrow disorder,,disease_ontology,,DOID:4961,,,,,,,,,,,,,,,,,,,bone marrow disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100520,"[""Olfactory receptor 2d2""]",,"An olfactory receptor 2D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H210] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H210] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100520,,,,https://pharos.nih.gov/idg/targets/Q9H210,,,,,,,,,,,,,OR2D2,OR2D1,,Q9H210,,,,,,,,Olfactory receptor 2d2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004500,"[""R1 cell""]",,"Mouse embryonic stem cell line; established from a 3.5 day blastocyst produced by crossing two 129 substrains, 129S1/SvImJ and 129X1/SvJ.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001581,,,,,,,,"Mouse embryonic stem cell line; established from a 3.5 day blastocyst produced by crossing two 129 substrains, 129S1/SvImJ and 129X1/SvJ.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004500,Marion,2010-02-08T12:27:38Z,,,,,BrendaTissueOBO,R1 ES cell,BTO:0004500,,,,,,,,,,,,,,,,,,,R1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200161,"[""GRK5 gene""]",,"This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400271,,,,,,,,"This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200161,,,,,,,,,,,,,,,,2869,GRK5,GPRK5,,,,,,,,,,GRK5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100013,"[""Neuronal acetylcholine receptor subunit alpha-9""]",,"A neuronal acetylcholine receptor subunit alpha-9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UGM1] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300497,,,,,,,,"A neuronal acetylcholine receptor subunit alpha-9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UGM1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100013,,,,https://pharos.nih.gov/idg/targets/Q9UGM1,,,,,,,,,,,,,CHRNA9,NACHRA9,,Q9UGM1,,,,,,,,Neuronal acetylcholine receptor subunit alpha-9,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000258,"[""MAP4K5 kinase domain""]",,Mitogen-activated protein kinase kinase kinase kinase 5; GCKR; KHS; KHS1; MAP4K5; MAPKKKK5,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase kinase kinase kinase 5; GCKR; KHS; KHS1; MAP4K5; MAPKKKK5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000258,,,,,,,,,,,,,,,,,,,200243,,,,,,,,,MAP4K5 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002790,"[""phloem parenchyma cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002790,,,,,,,BrendaTissueOBO,phloem parenchyma,BTO:0002790,,,,,,,,,,,,,,,,,,,phloem parenchyma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200115,"[""GABRB3 gene""]",,"This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one the subunits of a multi-subunit chloride channel that serves as the receptor for gamma-aminobutyric acid, a major inhibitory neurotransmitter of the mammalian nervous system. This gene is located on the long arm of chromosome 15 in a cluster with two other genes encoding related subunits of the family. This gene may be associated with the pathogenesis of several disorders including Angelman syndrome, Prader-Willi syndrome, nonsyndromic orofacial clefts, epilepsy and autism. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_01400514,,,,,,,,"This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one the subunits of a multi-subunit chloride channel that serves as the receptor for gamma-aminobutyric acid, a major inhibitory neurotransmitter of the mammalian nervous system. This gene is located on the long arm of chromosome 15 in a cluster with two other genes encoding related subunits of the family. This gene may be associated with the pathogenesis of several disorders including Angelman syndrome, Prader-Willi syndrome, nonsyndromic orofacial clefts, epilepsy and autism. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200115,,,,,,,,,,,,,,,,2562,GABRB3,,,,,,,,,,,GABRB3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100556,"[""Olfactory receptor 2W3""]",,"An olfactory receptor 2W3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z3T1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2W3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z3T1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100556,,,,https://pharos.nih.gov/idg/targets/Q7Z3T1,,,,,,,,,,,,,OR2W3,OR2W3P|OR2W8P,,Q7Z3T1,,,,,,,,Olfactory receptor 2W3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003840,"[""cerebrovascular system""]",,System pertaining to blood vessels in the brain.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,System pertaining to blood vessels in the brain.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003840,,,,,,,BrendaTissueOBO,,BTO:0003840,,,,,,,,,,,,,,,,,,,cerebrovascular system,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200291,"[""OR10A5 gene""]",,"An olfactory receptor 10A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H207] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H207] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200291,,,,,,,,,,,,,,,,144124,OR10A5,OR10A1,,,,,,,,,,OR10A5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100170,"[""Serine/threonine-protein kinase haspin""]",,"serine/threonine-protein kinase haspin (HASP)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase haspin that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TF76] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300161,,,,,,,,"serine/threonine-protein kinase haspin (HASP)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase haspin that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TF76] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100170,,,,https://pharos.nih.gov/idg/targets/Q8TF76,,,,,,,,,,,,,GSG2,,,Q8TF76,,,,,,,,Serine/threonine-protein kinase haspin,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200072,"[""CDK6 gene""]",,"The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400260,,,,,,,,"The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200072,,,,,,,,,,,,,,,,1021,CDK6,CDKN6,,,,,,,,,,CDK6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003874,"[""follicular thyroid cancer cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001610,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003874,,,,,,,BrendaTissueOBO,follicular thyroid carcinoma cell line,BTO:0003874,,,,,,,,,,,,,,,,,,,follicular thyroid cancer cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_60427,"[""dioleoyl phosphatidic acid""]","CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC|C39H73O8P|1,2-Dioleoyl-sn-glycero-3-phosphate|InChI=1S/C39H73O8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(40)45-35-37(36-46-48(42,43)44)47-39(41)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,37H,3-16,21-36H2,1-2H3,(H2,42,43,44)/b19-17-,20-18-|Dioleoylphosphatidic acid|MHUWZNTUIIFHAS-CLFAGFIQSA-N|1,2-dioleoylglycerol-3-phosphate|700.504|700.96590|PA(18:1/18:1)[U]|DOPA|PA(18:1(9Z)/18:1(9Z))[U]|0",A phosphatidic acid in which the phosphatidyl acyl groups are both oleoyl.,false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,CAS:14268-17-8|Beilstein:1917928|PMID:1602135|LIPID_MAPS_instance:LMGP10010031,A phosphatidic acid in which the phosphatidyl acyl groups are both oleoyl.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,"3-(phosphonooxy)propane-1,2-diyl (9Z,9'Z)bis-octadec-9-enoate",,chebi_ontology,"CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC|C39H73O8P|1,2-Dioleoyl-sn-glycero-3-phosphate|InChI=1S/C39H73O8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(40)45-35-37(36-46-48(42,43)44)47-39(41)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,37H,3-16,21-36H2,1-2H3,(H2,42,43,44)/b19-17-,20-18-|Dioleoylphosphatidic acid|MHUWZNTUIIFHAS-CLFAGFIQSA-N|1,2-dioleoylglycerol-3-phosphate|700.504|700.96590|PA(18:1/18:1)[U]|DOPA|PA(18:1(9Z)/18:1(9Z))[U]|0",,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:60427,,,,,dioleoyl phosphatidic acid,,CHEBI:60427,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000150,"[""breast cancer cell""]",,"Breast cancer is an uncontrolled growth of malignant breast tissue. Most breast cancers begin in the milk ducts: these are called intraductal cancers. A few, like lobular cancer, start in the milk sacs or lobes.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000604,,,,,,,,"Breast cancer is an uncontrolled growth of malignant breast tissue. Most breast cancers begin in the milk ducts: these are called intraductal cancers. A few, like lobular cancer, start in the milk sacs or lobes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000150,,,,,,,BrendaTissueOBO,mammary carcinoma cell|mammary cancer cell|breast carcinoma cell|breast adenocarcinoma cell|breast tumor cell|mammary adenocarcinoma cell|mammary tumor cell|breast epithelial cancer cell,BTO:0000150,,,,,,,,,,,,,,,,,,,breast cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5093,"[""thoracic cancer""]",,"An organ system cancer located_in the thoracic cavity that develops in the different types of cells within the lungs, as well as less common cancers of the esophagus, the trachea, or the chest wall.",false,,,http://purl.obolibrary.org/obo/DOID_0050686,,,,,,,,"An organ system cancer located_in the thoracic cavity that develops in the different types of cells within the lungs, as well as less common cancers of the esophagus, the trachea, or the chest wall.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5093,,,DOID:3937,SNOMEDCT_US_2016_03_01:188365003|MESH:D013899|SNOMEDCT_US_2016_03_01:255058005|ICD10CM:C76.1|UMLS_CUI:C0153661|ICD9CM:195.1|SNOMEDCT_US_2016_03_01:188361007|UMLS_CUI:C0039981|NCI:C3576|NCI:C3406,thorax neoplasm|thorax cancer|Thoracic tumor|tumor of thorax,,disease_ontology,,DOID:5093,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,thoracic cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391025,"[""Diacylglycerol kinase family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300323,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391025,,,,,,,,,,,,,,,,,,,,,,,,,,,,Diacylglycerol kinase family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000150,"[""MET220 in MLK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000150,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET220 in MLK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100262,"[""Tyrosine-protein kinase syk""]",,"tyrosine-protein kinase syk (SYK)  with  no mutation  in a nonphosphorylated state|A tyrosine-protein kinase SYK that is encoded in the genome of human. [PRO:CNA, UniProtKB:P43405] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300180,,,,,,,,"tyrosine-protein kinase syk (SYK)  with  no mutation  in a nonphosphorylated state|A tyrosine-protein kinase SYK that is encoded in the genome of human. [PRO:CNA, UniProtKB:P43405] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100262,,,,https://pharos.nih.gov/idg/targets/P43405,,,,,,,,,,,,,SYK,,,P43405,,,,,,,,Tyrosine-protein kinase syk,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000886,"[""mucosa""]",,"A membrane lining all body passages that communicate with the air, such as the respiratory and alimentary tracts, and having cells and associated glands that secrete mucus.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000634,,,,,,,,"A membrane lining all body passages that communicate with the air, such as the respiratory and alimentary tracts, and having cells and associated glands that secrete mucus.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000886,,,,,,,BrendaTissueOBO,tunica mucosa|mucous membrane,BTO:0000886,,,,,,,,,,,,,,,,,,,mucosa,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004909,"[""Purkinje layer""]",,"The cerebellar cortex is divided into three layers. At the bottom lies the thick granular layer. In the middle lies the Purkinje layer, a narrow zone that contains only the cell bodies of Purkinje cells. At the top lies the molecular layer.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The cerebellar cortex is divided into three layers. At the bottom lies the thick granular layer. In the middle lies the Purkinje layer, a narrow zone that contains only the cell bodies of Purkinje cells. At the top lies the molecular layer.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004909,mgr,2010-10-14T12:52:12Z,,,,,BrendaTissueOBO,Purkinje cell layer,BTO:0004909,,,,,,,,,,,,,,,,,,,Purkinje layer,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000250,"[""PHE230 in KKCC1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000250,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE230 in KKCC1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003252,"[""uterine leiomyoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003252,,,,,,,BrendaTissueOBO,,BTO:0003252,,,,,,,,,,,,,,,,,,,uterine leiomyoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200220,"[""KCNK9 gene""]",,"This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH-dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel mental retardation dysmorphism syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_01400359,,,,,,,,"This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH-dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel mental retardation dysmorphism syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200220,,,,,,,,,,,,,,,,51305,KCNK9,TASK3,,,,,,,,,,KCNK9 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_34972,"[""Secretin""]","
CC(C)CC(NC(=O)CNC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)C(C)NC(=O)C([*])NC(=O)C(C[*])NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCC(O)=O)NC(=O)C(CO)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)CNC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(N)Cc1ncc[nH]1)C(C)O)C(C)O)C(=O)NC(C(C)C)C(N)=O
|C130H220N44O41|Vitrum",,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG COMPOUND:C13523|KEGG COMPOUND:17034-35-4|KEGG COMPOUND:1393-25-5|KEGG DRUG:D02021,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Secretin,,chebi_ontology,"
CC(C)CC(NC(=O)CNC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)C(C)NC(=O)C([*])NC(=O)C(C[*])NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCC(O)=O)NC(=O)C(CO)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)CNC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(N)Cc1ncc[nH]1)C(C)O)C(C)O)C(=O)NC(C(C)C)C(N)=O
|C130H220N44O41|Vitrum",,,CHEBI:34972,,,,,,,,,,,,,,,,,,,,,,,CHEBI:34972,,,,,Secretin,,CHEBI:34972,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001793,"[""tectum mesencephali""]",,The dorsal part of the midbrain including the corpora quadrigemina.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The dorsal part of the midbrain including the corpora quadrigemina.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001793,,,,,,,BrendaTissueOBO,neuraxis tectum|tectum,BTO:0001793,,,,,,,,,,,,,,,,,,,tectum mesencephali,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9784,"[""trichinosis""]",,"A parasitic helminthiasis infectious disease that involves parasitic infection of animals and humans by Trichinella spiralis, Trichinella nativa or Trichinella britovi . Intestinal invasion causes diarrhea, abdominal pain and vomiting. Larval migration into muscle tissues can cause periorbital and facial edema, conjunctivitis, fever, myalgias, splinter hemorrhages, rashes, and blood eosinophilia. Myocarditis, central nervous system involvement, and pneumonitis can also occur.",false,,,http://purl.obolibrary.org/obo/DOID_883,,,,,,,,"A parasitic helminthiasis infectious disease that involves parasitic infection of animals and humans by Trichinella spiralis, Trichinella nativa or Trichinella britovi . Intestinal invasion causes diarrhea, abdominal pain and vomiting. Larval migration into muscle tissues can cause periorbital and facial edema, conjunctivitis, fever, myalgias, splinter hemorrhages, rashes, and blood eosinophilia. Myocarditis, central nervous system involvement, and pneumonitis can also occur.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9784,,,,SNOMEDCT_US_2016_03_01:88264003|NCI:C85199|ICD9CM:124|SNOMEDCT_US_2016_03_01:266222003|UMLS_CUI:C0040896|MESH:D014235|ICD10CM:B75|SNOMEDCT_US_2016_03_01:709018004|SNOMEDCT_US_2016_03_01:154415009,Trichinella spiralis infection,,disease_ontology,,DOID:9784,,,,,,,,,,,,,,,,,,,trichinosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200472,"[""SGK2 gene""]",,"This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400224,,,,,,,,"This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200472,,,,,,,,,,,,,,,,10110,SGK2,,,,,,,,,,,SGK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100231,"[""Intermediate conductance calcium-activated potassium channel protein 4""]",,An intermediate conductance calcium-activated potassium channel protein 4 that is encoded in the genome of human. [] ,false,,,http://www.drugtargetontology.org/dto/DTO_01300437,,,,,,,,An intermediate conductance calcium-activated potassium channel protein 4 that is encoded in the genome of human. [] ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100231,,,,https://pharos.nih.gov/idg/targets/O15554,,,,,,,,,,,,,KCNN4,IK1|IKCA1|KCA4|SK4,,O15554,,,,,,,,Intermediate conductance calcium-activated potassium channel protein 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/UBERON_0000002,"[""uterine cervix""]",cervical canal|cervix of uterus,"Lower, narrow portion of the uterus where it joins with the top end of the vagina.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,http://en.wikipedia.org/wiki/Cervix|http://linkedlifedata.com/resource/umls/id/C0007874|http://www.snomedbrowser.com/Codes/Details/245494008|OpenCyc:Mx4rvVipEJwpEbGdrcN5Y29ycA|GAID:376|FMA:17740|CALOHA:TS-0134|BTO:0001421|EMAPA:29927|MA:0000392|MAT:0000292|UMLS:C0007874|ncithesaurus:Cervix|BTO:0002249|VHOG:0001359|MESH:A05.360.319.679.256|galen:CervixUteri|EV:0100114|EFO:0000979,"Lower, narrow portion of the uterus where it joins with the top end of the vagina.",,,,,,,,,,The narrow caudal end of the uterus that opens into the vagina. [TFD][VHOG],,,,,,,,,,,,,,,,,,,,,,,,,cervix,cervical canal of uterus|caudal segment of uterus|cervix uteri|neck of uterus|uterine cervix|canalis cervicis uteri,,uberon,cervical canal|cervix of uterus,cervical,"The evolution of mammals is associated with radical changes in their reproductive biology, particularly the structure and function of the female reproductive organs. These changes include the evolution of the uterus, cervix, vagina, placenta and specialized cell types associated with each of those structures.[well established][VHOG]",,,,,,,,,,,,,,,,,,,,,,,,UBERON:0000002,,,,,uterine cervix,,UBERON:0000002,,http://purl.obolibrary.org/obo/uberon.owl,http://purl.obolibrary.org/obo/uberon/core#efo_slim|http://purl.obolibrary.org/obo/uberon/core#uberon_slim,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000762,"[""lung cancer cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0000353|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000297,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000762,,,,,,,BrendaTissueOBO,lung carcinoma cell line,BTO:0000762,,,,,,,,,,,,,,,,,,,lung cancer cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004462,"[""K-562R cell""]",,Imatinib resistant subline of K562.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Imatinib resistant subline of K562.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004462,Marion,2010-02-02T04:01:32Z,,,,,BrendaTissueOBO,K562R cell,BTO:0004462,,,,,,,,,,,,,,,,,,,K-562R cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000297,"[""MST2 kinase domain""]",,"Serine/threonine kinase 3 (STE20 homolog, yeast); FLJ90748; KRS1; MST2; STK3",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Serine/threonine kinase 3 (STE20 homolog, yeast); FLJ90748; KRS1; MST2; STK3",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000297,,,,,,,,,,,,,,,,,,,200274,,,,,,,,,MST2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000022,"[""ILE711 in EPHA7""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30009,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000022,,,,,,,,,,,,,,,,,,,,,,,,,,,,ILE711 in EPHA7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004980,"[""uveal melanoma cell""]",,Ocular melanoma consisting of overgrowth of uveal melanocytes.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000848,,,,,,,,Ocular melanoma consisting of overgrowth of uveal melanocytes.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004980,XPMUser,2011-02-26T11:12:21Z,,,,,BrendaTissueOBO,,BTO:0004980,,,,,,,,,,,,,,,,,,,uveal melanoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000450,"[""TYK2(JH2domain-pseudokinase) kinase domain""]",,Non-receptor tyrosine-protein kinase TYK2; Tyrosine kinase 2; JTK1; TYK2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Non-receptor tyrosine-protein kinase TYK2; Tyrosine kinase 2; JTK1; TYK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000450,,,,,,,,,,,,,,,,,,,"200451, 200453",,,,,,,,,TYK2(JH2domain-pseudokinase) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100472,"[""Short-wave-sensitive opsin 1""]",,"A short-wave-sensitive opsin 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P03999] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A short-wave-sensitive opsin 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P03999] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100472,,,,https://pharos.nih.gov/idg/targets/P03999,,,,,,,,,,,,,OPN1SW,BCP,,P03999,,,,,,,,Short-wave-sensitive opsin 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000025,"[""ABL1-nonphosphorylated kinase domain""]",,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",false,,,http://www.drugtargetontology.org/dto/DTO_61000003,,,,,,,,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000025,,,,,,,,,,,,,,,,,,,"200002, 200024",,,,,,,,,ABL1-nonphosphorylated kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400355,"[""Potassium channel family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400355,,,,,,,,,,,,,,,,,,,,,,,,,,,,Potassium channel family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2106,"[""myotonia congenita""]",,A muscle tissue disease that is characterised by slow muscle relaxation associated with hyperexcitation of the muscle fibres.,false,,,http://purl.obolibrary.org/obo/DOID_66,,,,,,,,A muscle tissue disease that is characterised by slow muscle relaxation associated with hyperexcitation of the muscle fibres.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2106,,,,NCI:C84912|ICD9CM:359.22|MESH:D009224|OMIM:255700|UMLS_CUI:C0027127|ORDO:614|OMIM:160800,"Congenital myotonia, autosomal dominant form (disorder)|Thomsen's disease|Thomsen disease",,disease_ontology,,DOID:2106,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,myotonia congenita,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100197,"[""Tyrosine-protein kinase jak2""]",,"A tyrosine-protein kinase JAK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60674] |tyrosine-protein kinase jak2 (JAK2(JH1domain-catalytic))  with  no mutation  in a nonphosphorylated state|tyrosine-protein kinase jak2 (JAK2(Kin.Dom.2))  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300167,,,,,,,,"A tyrosine-protein kinase JAK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60674] |tyrosine-protein kinase jak2 (JAK2(JH1domain-catalytic))  with  no mutation  in a nonphosphorylated state|tyrosine-protein kinase jak2 (JAK2(Kin.Dom.2))  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100197,,,,https://pharos.nih.gov/idg/targets/O60674,,,,,,,,,,,,,JAK2,,,O60674,,,,,,,,Tyrosine-protein kinase jak2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005093,"[""intercalated cell""]",,"Each component of the collecting duct system contains two cell types, intercalated cells and a segment-specific cell type.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Each component of the collecting duct system contains two cell types, intercalated cells and a segment-specific cell type.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005093,XPMUser,2011-03-08T09:40:36Z,,,,,BrendaTissueOBO,,BTO:0005093,,,,,,,,,,,,,,,,,,,intercalated cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000216,"[""MET90 in MAP4K2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000216,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET90 in MAP4K2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200628,"[""XYLB gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200628,,,,,,,,,,,,,,,,,,,,,,,,,,,,XYLB gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100051,"[""Mitotic checkpoint serine/threonine-protein kinase bub1 beta""]",,A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of human. [Reactome:REACT_3972] ,false,,,http://www.drugtargetontology.org/dto/DTO_03300134,,,,,,,,A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of human. [Reactome:REACT_3972] ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100051,,,,https://pharos.nih.gov/idg/targets/O60566,,,,,,,,,,,,,BUB1B,BUBR1|MAD3L|SSK1,,O60566,,,,,,,,Mitotic checkpoint serine/threonine-protein kinase bub1 beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300216,"[""RET family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300216,,,,,,,,,,,,,,,,,,,,,,,,,,,,RET family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000556,"[""germ layer""]",,"A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000556,,,,,,,BrendaTissueOBO,,BTO:0000556,,,,,,,,,,,,,,,,,,,germ layer,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1214,"[""tympanosclerosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5782,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1214,,,,UMLS_CUI:C0155477|SNOMEDCT_US_2016_03_01:111540000|ICD9CM:385.09,,,disease_ontology,,DOID:1214,,,,,,,,,,,,,,,,,,,tympanosclerosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12144,"[""low compliance bladder""]",,,false,,,http://purl.obolibrary.org/obo/DOID_365,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12144,,,,ICD9CM:596.52|SNOMEDCT_US_2016_03_01:9009001|UMLS_CUI:C0489967,Low bladder compliance|hyperactivity of bladder|hypertonicity of bladder|hypertonic bladder,,disease_ontology,,DOID:12144,,,,,,,,,,,,,,,,,,,low compliance bladder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12143,"[""neurogenic bladder""]",,,false,,,http://purl.obolibrary.org/obo/DOID_365,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12143,,,,SNOMEDCT_US_2016_03_01:155032006|MESH:D001750|SNOMEDCT_US_2016_03_01:23201000|ICD9CM:596.54|NCI:C79696|SNOMEDCT_US_2016_03_01:397732007|SNOMEDCT_US_2016_03_01:398064005|SNOMEDCT_US_2016_03_01:192972000|UMLS_CUI:C0005697|SNOMEDCT_US_2016_03_01:197883004,neurogenic urinary bladder disorder|Neuropathic bladder|neurogenic dysfunction of the urinary bladder,,disease_ontology,,DOID:12143,,,,,,,,,,,,,,,,,,,neurogenic bladder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12140,"[""Chagas disease""]",,"A trypanosomiasis that is a tropical parasitic disease caused by the flagellate protozoan Trypanosoma cruzi, which is transmitted to humans and other mammals by an insect vector, the blood-sucking assassin bugs of the subfamily Triatominae (family Reduviidae), most commonly species belonging to the Triatoma, Rhodnius, and Panstrongylus genera. The symptoms include fever, fatigue, body aches, headache, rash, loss of appetite, diarrhea, vomiting, swelling of the eyelids and myocarditis.",false,,,http://purl.obolibrary.org/obo/DOID_10113,,,,,,,,"A trypanosomiasis that is a tropical parasitic disease caused by the flagellate protozoan Trypanosoma cruzi, which is transmitted to humans and other mammals by an insect vector, the blood-sucking assassin bugs of the subfamily Triatominae (family Reduviidae), most commonly species belonging to the Triatoma, Rhodnius, and Panstrongylus genera. The symptoms include fever, fatigue, body aches, headache, rash, loss of appetite, diarrhea, vomiting, swelling of the eyelids and myocarditis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12140,,,DOID:0050016|DOID:0050019|DOID:0050020,KEGG:05142|SNOMEDCT_US_2016_03_01:94371000119107|ICD9CM:086.2|SNOMEDCT_US_2016_03_01:186817003|UMLS_CUI:C0007932|SNOMEDCT_US_2016_03_01:54570006,chagas' disease with nervous system involvement|chagas' disease with digestive system involvement|chagas' disease with other organ involvement|Chagas' disease,,disease_ontology,American trypanosomiasis,DOID:12140,http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,Chagas disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000285,"[""MLTK kinase domain""]",,Mitogen-activated protein kinase kinase kinase MLT; sterile alpha motif and leucine zipper containing kinase AZK; AZK; MLK7; mlklak; MLT; MLTK; MRK; pk; ZAK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase kinase kinase MLT; sterile alpha motif and leucine zipper containing kinase AZK; AZK; MLK7; mlklak; MLT; MLTK; MRK; pk; ZAK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000285,,,,,,,,,,,,,,,,,,,200468,,,,,,,,,MLTK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8544,"[""chronic fatigue syndrome""]",,"A syndrome that involves prolonged and severe tiredness or weariness that is unrelated to exertion, is not relieved by rest and for a minimum of six months and is not directly caused by other conditions.",false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,"A syndrome that involves prolonged and severe tiredness or weariness that is unrelated to exertion, is not relieved by rest and for a minimum of six months and is not directly caused by other conditions.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8544,,,,SNOMEDCT_US_2016_03_01:154991009|SNOMEDCT_US_2016_03_01:154989001|SNOMEDCT_US_2016_03_01:193054000|SNOMEDCT_US_2016_03_01:267683005|SNOMEDCT_US_2016_03_01:271798008|ICD9CM:780.71|SNOMEDCT_US_2016_03_01:52702003|SNOMEDCT_US_2016_03_01:192735003|ICD10CM:R53.82|UMLS_CUI:C0015674|ICD10CM:G93.3|SNOMEDCT_US_2016_03_01:51771007|SNOMEDCT_US_2016_03_01:247372003|SNOMEDCT_US_2016_03_01:155062000|MESH:D015673|NCI:C3037|SNOMEDCT_US_2016_03_01:267684004,Postviral fatigue syndrome (disorder)|CFS|Myalgic encephalitis|Myalgic encephalomyelitis,,disease_ontology,,DOID:8544,,,,,,,,,,,,,,,,,"No OMIM mapping, confirmed by DO. [LS].",,chronic fatigue syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3223,"[""complex regional pain syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_11465,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3223,,,,SNOMEDCT_US_2016_03_01:128200000|MESH:D020918|UMLS_CUI:C0458219,Complex regional pain syndromes (disorder),,disease_ontology,,DOID:3223,,,,,,,,,,,,,,,,,,,complex regional pain syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000037,"[""CCL5""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000037,,,,,,,,,,,,,,,,,,,,,,,,,,,,CCL5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003167,"[""143B cell""]",,Human fibroblast osteosarcoma cell line lacking the thymidine kinase (TK) gene.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000407,,,,,,,,Human fibroblast osteosarcoma cell line lacking the thymidine kinase (TK) gene.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003167,,,,,,,BrendaTissueOBO,143BTK cell,BTO:0003167,,,,,,,,,,,,,,,,,,,143B cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100047,"[""Serine/threonine-protein kinase b-raf""]",,"serine/threonine-protein kinase b-raf (BRAF)  with  no mutation  in a nonphosphorylated state|serine/threonine-protein kinase b-raf (BRAF(V600E))  with  mutation E600 in BRAF(V600E) in a nonphosphorylated state|A B-Raf proto-oncogene serine/threonine-protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P15056] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300126,,,,,,,,"serine/threonine-protein kinase b-raf (BRAF)  with  no mutation  in a nonphosphorylated state|serine/threonine-protein kinase b-raf (BRAF(V600E))  with  mutation E600 in BRAF(V600E) in a nonphosphorylated state|A B-Raf proto-oncogene serine/threonine-protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P15056] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100047,,,,https://pharos.nih.gov/idg/targets/P15056,,,,,,,,,,,,,BRAF,BRAF1|RAFB1,,P15056,,,,,,,,Serine/threonine-protein kinase b-raf,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400255,"[""CRK7 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400136,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400255,,,,,,,,,,,,,,,,,,,,,,,,,,,,CRK7 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002368,"[""3Y1-B clone 1 cell""]",,"Rat Fischer cell line; established from a female rat embryo /whole fetus. Mother clone of 3Y1 series, fibroblast-like.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001242|http://purl.obolibrary.org/obo/BTO_0001958,,,,,,,,"Rat Fischer cell line; established from a female rat embryo /whole fetus. Mother clone of 3Y1 series, fibroblast-like.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002368,,,,,,,BrendaTissueOBO,3Y1 cell,BTO:0002368,,,,,,,,,,,,,,,,,,,3Y1-B clone 1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000090,"[""CLK1 kinase domain""]",,CDC-like kinase 1; CLK; CLK/STY; CLK1; STY,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,CDC-like kinase 1; CLK; CLK/STY; CLK1; STY,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000090,,,,,,,,,,,,,,,,,,,200090,,,,,,,,,CLK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100028,"[""Atrial natriuretic peptide receptor 1""]",,"An atrial natriuretic peptide receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P16066] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300125,,,,,,,,"An atrial natriuretic peptide receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P16066] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100028,,,,https://pharos.nih.gov/idg/targets/P16066,,,,,,,,,,,,,NPR1,ANPRA,,P16066,,,,,,,,Atrial natriuretic peptide receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200210,"[""KCNH6 gene""]",,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_01400558,,,,,,,,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200210,,,,,,,,,,,,,,,,81033,KCNH6,ERG2,,,,,,,,,,KCNH6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000207,"[""CCL23""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000207,,,,,,,,,,,,,,,,,,,,,,,,,,,,CCL23,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000438,"[""TNIK kinase domain""]",,TRAF2 and NCK interacting kinase; TNIK; TNIK/ZC2; ZC2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,TRAF2 and NCK interacting kinase; TNIK; TNIK/ZC2; ZC2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000438,,,,,,,,,,,,,,,,,,,200439,,,,,,,,,TNIK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300127,"[""GRK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300127,,,,,,,,,,,,,,,,,,,,,,,,,,,,GRK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001346,"[""tachyzoite""]",,"Oval, quickly multiplying trophozoite of Toxoplasma gondii, found in all tissues except non-nucleated erythrocytes during the acute stage of toxoplasmosis.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001397,,,,,,,,"Oval, quickly multiplying trophozoite of Toxoplasma gondii, found in all tissues except non-nucleated erythrocytes during the acute stage of toxoplasmosis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001346,,,,,,,BrendaTissueOBO,endocoite,BTO:0001346,,,,,,,,,,,,,,,,,,,tachyzoite,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400033,"[""Leukotriene receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400033,,,,,,,,,,,,,,,,,,,,,,,,,,,,Leukotriene receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001232,"[""seminal plasma""]",,"The fluid portion of the semen, in which the spermatozoa are suspended.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The fluid portion of the semen, in which the spermatozoa are suspended.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001232,,,,,,,BrendaTissueOBO,prostate fluid|seminal fluid|prostatic fluid,BTO:0001232,,,,,,,,,,,,,,,,,,,seminal plasma,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2373,"[""hereditary elliptocytosis""]",,"A hematopoietic system disease characterized by oval or elliptical red blood cells, slight or absent hemolysis with little or no anemia; splenomegaly is often present.",false,,,http://purl.obolibrary.org/obo/DOID_74,,,,,,,,"A hematopoietic system disease characterized by oval or elliptical red blood cells, slight or absent hemolysis with little or no anemia; splenomegaly is often present.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2373,,,,SNOMEDCT_US_2016_03_01:191169008|NCI:C36293|ORDO:288|SNOMEDCT_US_2016_03_01:267558001|UMLS_CUI:C0013902|SNOMEDCT_US_2016_03_01:178935009|OMIM:130600|SNOMEDCT_US_2016_03_01:154801000|NCI:C35882|OMIM:611804|ICD9CM:282.1|ICD10CM:D58.1|SNOMEDCT_US_2016_03_01:58864003|MESH:D004612,Congenital elliptocytosis|ovalocytosis,,disease_ontology,,DOID:2373,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,hereditary elliptocytosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200448,"[""OR5AK3P gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200448,,,,,,,,,,,,,,,,81228,OR5AK3P,OR5AK3,,,,,,,,,,OR5AK3P gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200006,"[""HTR2A gene""]",,"A 5-hydroxytryptamine receptor 2A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28223] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402002,,,,,,,,"A 5-hydroxytryptamine receptor 2A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28223] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200006,,,,,,,,,,,,,,,,3356,HTR2A,HTR2,,,,,,,,,,HTR2A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2987,"[""familial Mediterranean fever""]",,"A hypersensitivity reaction type II disease characterized by recurrent episodes of fever and acute inflammation of the membranes lining the abdomen, joints and lungs; that has material basis in mutations in the MEFV gene, which encodes the protein pyrin.",false,,,http://purl.obolibrary.org/obo/DOID_417,,,,,,,,"A hypersensitivity reaction type II disease characterized by recurrent episodes of fever and acute inflammation of the membranes lining the abdomen, joints and lungs; that has material basis in mutations in the MEFV gene, which encodes the protein pyrin.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2987,,,,ICD9CM:277.31|UMLS_CUI:C0031069|ICD10CM:E85.0|NCI:C84707|SNOMEDCT_US_2016_03_01:12579009|MESH:D010505|ORDO:342|OMIM:134610|OMIM:249100,benign paroxysmal peritonitis,,disease_ontology,,DOID:2987,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,familial Mediterranean fever,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100008,"[""Neuronal acetylcholine receptor subunit alpha-3""]",,"A neuronal acetylcholine receptor subunit alpha-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P32297] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300492,,,,,,,,"A neuronal acetylcholine receptor subunit alpha-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P32297] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100008,,,,https://pharos.nih.gov/idg/targets/P32297,,,,,,,,,,,,,CHRNA3,NACHRA3,,P32297,,,,,,,,Neuronal acetylcholine receptor subunit alpha-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002938,"[""33B cell""]",,Rat nervous tissue oligodendroglioma cell line. 33B is a N-Ethyl-N-nitrosourea-induced neural tumour cell line derived from 17th in vivo passage of TR33B.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002820,,,,,,,,Rat nervous tissue oligodendroglioma cell line. 33B is a N-Ethyl-N-nitrosourea-induced neural tumour cell line derived from 17th in vivo passage of TR33B.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002938,,,,,,,BrendaTissueOBO,,BTO:0002938,,,,,,,,,,,,,,,,,,,33B cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_33709,"[""amino acid""]",amino acids|Aminosaeure|Aminocarbonsaeure|.|Aminokarbonsaeure,"A carboxylic acid containing one or more amino groups.|
A carboxylic acid containing one or more amino groups.
",false,,,http://purl.obolibrary.org/obo/CHEBI_23367,,,,,,,Wikipedia:Amino_acid,"A carboxylic acid containing one or more amino groups.|
A carboxylic acid containing one or more amino groups.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:22477|CHEBI:13815,,,,chebi_ontology,amino acids|Aminosaeure|Aminocarbonsaeure|.|Aminokarbonsaeure,,,CHEBI:33709,,,,,,,,,,,,,,,,,,,,,,,CHEBI:33709,,,,,Amino acid|amino acid,,CHEBI:33709,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12959,"[""lagophthalmos""]",,,false,,,http://purl.obolibrary.org/obo/DOID_530,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12959,,,,ICD10CM:H02.2|ICD9CM:374.2|ICD9CM:374.20|SNOMEDCT_US_2016_03_01:60735000|SNOMEDCT_US_2016_03_01:193936001|SNOMEDCT_US_2016_03_01:193941009|SNOMEDCT_US_2016_03_01:193937005|ICD10CM:H02.20|UMLS_CUI:C0152226,,,disease_ontology,,DOID:12959,,,,,,,,,,,,,,,,,,,lagophthalmos,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8440,"[""ileus""]",,,false,,,http://purl.obolibrary.org/obo/DOID_8437,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8440,,,,SNOMEDCT_US_2016_03_01:81060008|MESH:D045823|UMLS_CUI:C1258215|NCI:C37979|SNOMEDCT_US_2016_03_01:278524008,Ileus of intestine,,disease_ontology,,DOID:8440,,,,,,,,,,,,,,,,,,,ileus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000225,"[""CEM cell""]",,CEM is a camptothecin (CPT) resistant derivative of the human T cell leukemia cell line CCRF-CEM. The cell line was selected and subcloned in 1991 for resistance to CPT. Established from an 4-year-old caucasian female.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,CEM is a camptothecin (CPT) resistant derivative of the human T cell leukemia cell line CCRF-CEM. The cell line was selected and subcloned in 1991 for resistance to CPT. Established from an 4-year-old caucasian female.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000225,,,,,,,BrendaTissueOBO,,BTO:0000225,,,,,,,,,,,,,,,,,,,CEM cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400302,"[""FRAY subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400187,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400302,,,,,,,,,,,,,,,,,,,,,,,,,,,,FRAY subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200001,"[""AAK1 gene""]",,"Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400115,,,,,,,,"Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200001,,,,,,,,,,,,,,,,22848,AAK1,KIAA1048,,,,,,,,,,AAK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100003,"[""5'-AMP-activated protein kinase subunit gamma-1""]",,"A 5'-AMP-activated protein kinase subunit gamma-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54619] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300116,,,,,,,,"A 5'-AMP-activated protein kinase subunit gamma-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54619] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100003,,,,https://pharos.nih.gov/idg/targets/P54619,,,,,,,,,,,,,PRKAG1,,,P54619,,,,,,,,5'-AMP-activated protein kinase subunit gamma-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100038,"[""Activin receptor type-2a""]",,"activin receptor type-2a (ACVR2A)  with  no mutation  in a nonphosphorylated state|An activin receptor type-2A that is encoded in the genome of human. [PRO:CNA, UniProtKB:P27037] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300252,,,,,,,,"activin receptor type-2a (ACVR2A)  with  no mutation  in a nonphosphorylated state|An activin receptor type-2A that is encoded in the genome of human. [PRO:CNA, UniProtKB:P27037] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100038,,,,https://pharos.nih.gov/idg/targets/P27037,,,,,,,,,,,,,ACVR2A,ACVR2,,P27037,,,,,,,,Activin receptor type-2a,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000399,"[""RSK3(Kin.Dom.2-C-terminal) kinase domain""]",,"Ribosomal protein S6 kinase, 90kDa, polypeptide 2; HU-2; MAPKAPK1C; p90RSK; p90-RSK3; pp90RSK3; RPS6KA2; RSK; RSK1; RSK1/p90RSK; RSK3; S6K-alpha; S6K-alpha2",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Ribosomal protein S6 kinase, 90kDa, polypeptide 2; HU-2; MAPKAPK1C; p90RSK; p90-RSK3; pp90RSK3; RPS6KA2; RSK; RSK1; RSK1/p90RSK; RSK3; S6K-alpha; S6K-alpha2",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000399,,,,,,,,,,,,,,,,,,,"200387, 200403",,,,,,,,,RSK3(Kin.Dom.2-C-terminal) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100199,"[""G-protein coupled receptor 4""]",,"A G-protein coupled receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46093] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300053,,,,,,,,"A G-protein coupled receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46093] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100199,,,,https://pharos.nih.gov/idg/targets/P46093,,,,,,,,,,,,,GPR4,GPR19,,P46093,,,,,,,,G-protein coupled receptor 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200228,"[""MVK gene""]",,"This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03491007,,,,,,,,"This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200228,,,,,,,,,,,,,,,,4598,MVK,,,,,,,,,,,MVK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100622,"[""Ribose-phosphate pyrophosphokinase 1""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100622,,,,,,,,,,,,,,,,,PRPS1,,,P60891,,,,,,,,Ribose-phosphate pyrophosphokinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4639,"[""suppurative lymphadenitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1602,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4639,,,,SNOMEDCT_US_2016_03_01:48573006|UMLS_CUI:C0392051|NCI:C27135,Suppurative lymphadenopathy (disorder),,disease_ontology,,DOID:4639,,,,,,,,,,,,,,,,,,,suppurative lymphadenitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001243,"[""shoot""]",,A sending out of new growth or the growth sent out: as a stem or branch with its leaves and appendages especially when not yet mature.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001461,,,,,,,,A sending out of new growth or the growth sent out: as a stem or branch with its leaves and appendages especially when not yet mature.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001243,,,,,,,BrendaTissueOBO,,BTO:0001243,,,,,,,,,,,,,,,,,,,shoot,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300200,"[""TRK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300200,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200132,"[""EPHA8 gene""]",,"This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400153,,,,,,,,"This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200132,,,,,,,,,,,,,,,,2046,EPHA8,EEK|HEK3|KIAA1459,,,,,,,,,,EPHA8 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005744,"[""vegetative stage""]",,The pre-flowering stage of a plant.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000720,,,,,,,,The pre-flowering stage of a plant.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005744,Marion,2015-04-27T11:57:29Z,,,,,BrendaTissueOBO,pre-flowering stage,BTO:0005744,,,,,,,,,,,,,,,,,,,vegetative stage,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100264,"[""P2X purinoceptor 1""]",,"A P2X purinoceptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51575] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300364,,,,,,,,"A P2X purinoceptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51575] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100264,,,,https://pharos.nih.gov/idg/targets/P51575,,,,,,,,,,,,,P2RX1,P2X1,,P51575,,,,,,,,P2X purinoceptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100550,"[""Olfactory receptor 2t6""]",,"An olfactory receptor 2T6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHC8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2T6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHC8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100550,,,,https://pharos.nih.gov/idg/targets/Q8NHC8,,,,,,,,,,,,,OR2T6,OR2T6P|OR2T9,,Q8NHC8,,,,,,,,Olfactory receptor 2t6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1793,"[""pancreatic cancer""]",,An endocrine gland cancer located_in the pancreas.,false,,,http://purl.obolibrary.org/obo/DOID_170,,,,,,,,An endocrine gland cancer located_in the pancreas.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1793,,,DOID:1797|DOID:9859|DOID:14356|DOID:3588,SNOMEDCT_US_2016_03_01:187796007|ORDO:1333|SNOMEDCT_US_2016_03_01:93823001|SNOMEDCT_US_2016_03_01:269554007|ICD9CM:157.8|ICD9CM:157.1|OMIM:606856|ICD10CM:C25.0|ICD9CM:157.0|OMIM:613347|ICD9CM:157.2|ICD10CM:C25.1|OMIM:614320|SNOMEDCT_US_2016_03_01:93715005|SNOMEDCT_US_2016_03_01:154477005|KEGG:05212|SNOMEDCT_US_2016_03_01:154478000|SNOMEDCT_US_2016_03_01:363419009|SNOMEDCT_US_2016_03_01:94082003|SNOMEDCT_US_2016_03_01:269555008|UMLS_CUI:C0030297|SNOMEDCT_US_2016_03_01:126859007|UMLS_CUI:C0153458|OMIM:613348|NCI:C3305|SNOMEDCT_US_2016_03_01:269553001|SNOMEDCT_US_2016_03_01:187791002|UMLS_CUI:C0153459|MESH:D010190|UMLS_CUI:C0153463|ICD10CM:C25.2|SNOMEDCT_US_2016_03_01:187792009|ORDO:217074|UMLS_CUI:C0153460|SNOMEDCT_US_2016_03_01:154476001,Ca head of pancreas|pancreatic tumor|Ca tail of pancreas|pancreatic neoplasm|Ca body of pancreas|malignant neoplasm of head of pancreas|malignant neoplasm of body of pancreas|malignant neoplasm of tail of pancreas|pancreas neoplasm,,disease_ontology,,DOID:1793,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,Xref MGI.,,pancreatic cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000579,"[""eye cancer cell""]",,A cell of a cancerous growth in any part of the eye.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A cell of a cancerous growth in any part of the eye.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000579,,,,,,,BrendaTissueOBO,,BTO:0000579,,,,,,,,,,,,,,,,,,,eye cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000725,"[""hematopoietic stem cell""]",,"A blood cell progenitor or mother cell representing a slightly later stage than the blast cell; it has the capacity for both replication and differentiation, and has pluripotentiality, giving rise to precursors of various different blood cell lines, such as the proerythrocyte and myeloblast, which cannot self-replicate and must differentiate into more mature daughter cells.",false,,,http://purl.obolibrary.org/obo/BTO_0002666|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A blood cell progenitor or mother cell representing a slightly later stage than the blast cell; it has the capacity for both replication and differentiation, and has pluripotentiality, giving rise to precursors of various different blood cell lines, such as the proerythrocyte and myeloblast, which cannot self-replicate and must differentiate into more mature daughter cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000725,,,,,,,BrendaTissueOBO,HSC|HSC cell|hemopoietic stem cell|progenitor cell|hemopoietic progenitor cell|CFU-S|hematopoietic precursor cell|colony forming unit spleen|hematopoietic progenitor cell|blutbildende Stammzelle,BTO:0000725,,,,,,,,,,,,,,,,,,,hematopoietic stem cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100189,"[""Inositol polyphosphate multikinase""]",,"An inositol polyphosphate multikinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFU5] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391019,,,,,,,,"An inositol polyphosphate multikinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFU5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100189,,,,https://pharos.nih.gov/idg/targets/Q8NFU5,,,,,,,,,,,,,IPMK,IMPK,,Q8NFU5,,,,,,,,Inositol polyphosphate multikinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100635,"[""Olfactory receptor 5l2""]",,"An olfactory receptor 5L2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5L2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100635,,,,https://pharos.nih.gov/idg/targets/Q8NGL0,,,,,,,,,,,,,OR5L2,,,Q8NGL0,,,,,,,,Olfactory receptor 5l2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200395,"[""OR51F2 gene""]",,"An olfactory receptor 51F2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH61] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 51F2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH61] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200395,,,,,,,,,,,,,,,,119694,OR51F2,,,,,,,,,,,OR51F2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100607,"[""N-acetyl-D-glucosamine kinase""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100607,,,,,,,,,,,,,,,,,NAGK,,,Q9UJ70,,,,,,,,N-acetyl-D-glucosamine kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9720,"[""vitreous disease""]",,An eye and adnexa disease that is located in the vitreous of the eye.,false,,,http://purl.obolibrary.org/obo/DOID_1492,,,,,,,,An eye and adnexa disease that is located in the vitreous of the eye.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9720,,,,SNOMEDCT_US_2016_03_01:194154006|SNOMEDCT_US_2016_03_01:194636006|ICD9CM:379.24|ICD10CM:H43.3|ICD10CM:H43.39|UMLS_CUI:C0029872,,,disease_ontology,,DOID:9720,,,,,,,,,,,,,,,,,,,vitreous disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217473,"[""Estrogen-related receptors gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00200002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217473,,,,,,,,,,,,,,,,,,,,,,,,,,,,Estrogen-related receptors gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004778,"[""medium spiny neuron""]",,"A special type of inhibitory cells representing approximately 90% of the neurons within the corpus striatum of the basal ganglia. They play a key role in initiating and controlling movements of the body, limbs and eyes.",false,,,http://purl.obolibrary.org/obo/BTO_0000938|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A special type of inhibitory cells representing approximately 90% of the neurons within the corpus striatum of the basal ganglia. They play a key role in initiating and controlling movements of the body, limbs and eyes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004778,mgr,2010-10-04T08:55:16Z,,,,,BrendaTissueOBO,MSN|spiny projection neuron|medium-sized densely spiny neuron,BTO:0004778,,,,,,,,,,,,,,,,,,,medium spiny neuron,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400519,"[""GABRG3 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400519,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRG3 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000043,"[""ANKK1 kinase domain""]",,Ankyrin repeat and kinase domain containing 1; ANKK1; PKK2; SgK288,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Ankyrin repeat and kinase domain containing 1; ANKK1; PKK2; SgK288,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000043,,,,,,,,,,,,,,,,,,,200040,,,,,,,,,ANKK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002264,"[""dried cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002322,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002264,,,,,,,BrendaTissueOBO,,BTO:0002264,,,,,,,,,,,,,,,,,,,dried cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300093,"[""Alpha adrenoceptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300022,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300093,,,,,,,,,,,,,,,,,,,,,,,,,,,,Alpha adrenoceptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001173,"[""reticulocyte""]",,An immature red blood cell that appears especially during regeneration of lost blood and has a fine basophilic reticulum formed of ribosomal remains.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000424|http://purl.obolibrary.org/obo/BTO_0001441,,,,,,,,An immature red blood cell that appears especially during regeneration of lost blood and has a fine basophilic reticulum formed of ribosomal remains.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001173,,,,,,,BrendaTissueOBO,,BTO:0001173,,,,,,,,,,,,,,,,,,,reticulocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000299,"[""MST4 kinase domain""]",,Serine/threonine protein kinase MST4; MASK; MST4,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine protein kinase MST4; MASK; MST4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000299,,,,,,,,,,,,,,,,,,,200276,,,,,,,,,MST4 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300526,"[""GLRA2 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300409,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300526,,,,,,,,,,,,,,,,,,,,,,,,,,,,GLRA2 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200070,"[""CNR1 gene""]",,"A cannabinoid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21554] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400035,,,,,,,,"A cannabinoid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21554] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200070,,,,,,,,,,,,,,,,1268,CNR1,CNR,,,,,,,,,,CNR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200760,"[""RXFP4 gene""]",,"A relaxin-3 receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDU9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A relaxin-3 receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDU9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200760,,,,,,,,,,,,,,,,339403,RXFP4,GPR100|RLN3R2,,,,,,,,,,RXFP4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400002,"[""Class A rhodopsin like gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400001,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,Class A rhodopsin like gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100316,"[""Transmembrane channel-like protein 8""]",,"A transmembrane channel-like protein 8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IU68] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300329,,,,,,,,"A transmembrane channel-like protein 8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IU68] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100316,,,,https://pharos.nih.gov/idg/targets/Q8IU68,,,,,,,,,,,,,TMC8,EVER2|EVIN2,,Q8IU68,,,,,,,,Transmembrane channel-like protein 8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4810,"[""cerebrotendinous xanthomatosis""]",,"A xanthomatosis that is characterized by a deficiency in the production of the bile acid, chenodeoxycholic acid that has_material_basis_in autosomal recessive inheritance and results in cholestanol deposition in the brain and other tissues and with elevated levels of cholesterol in plasma.",false,,,http://purl.obolibrary.org/obo/DOID_3345,,,,,,,,"A xanthomatosis that is characterized by a deficiency in the production of the bile acid, chenodeoxycholic acid that has_material_basis_in autosomal recessive inheritance and results in cholestanol deposition in the brain and other tissues and with elevated levels of cholesterol in plasma.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4810,,,,SNOMEDCT_US_2016_03_01:63246000|MESH:D019294|OMIM:213700|NCI:C84628|UMLS_CUI:C0238052,Cholestanol storage disease (disorder),,disease_ontology,,DOID:4810,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,cerebrotendinous xanthomatosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200034,"[""ADRB2 gene""]",,"A beta-2 adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P07550] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400094,,,,,,,,"A beta-2 adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P07550] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200034,,,,,,,,,,,,,,,,154,ADRB2,ADRB2R|B2AR,,,,,,,,,,ADRB2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200169,"[""GPR183 gene""]",,"A G-protein coupled receptor 183 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32249] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 183 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32249] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200169,,,,,,,,,,,,,,,,1880,GPR183,EBI2,,,,,,,,,,GPR183 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1657,"[""ventricular septal defect""]",,"A heart septal defect characterized by an opening in the interventricular septum, causing a shunt between ventricles.",false,,,http://purl.obolibrary.org/obo/DOID_1681,,,,,,,,"A heart septal defect characterized by an opening in the interventricular septum, causing a shunt between ventricles.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1657,,,,SNOMEDCT_US_2016_03_01:204309000|UMLS_CUI:C0018818|OMIM:614431|ORDO:1480|SNOMEDCT_US_2016_03_01:253549006|SNOMEDCT_US_2016_03_01:270547008|SNOMEDCT_US_2016_03_01:204314001|OMIM:614429|NCI:C84506|ICD9CM:745.4|MESH:D006345|SNOMEDCT_US_2016_03_01:156914003|ICD10CM:Q21.0|OMIM:614432|SNOMEDCT_US_2016_03_01:204310005|SNOMEDCT_US_2016_03_01:30288003,Ventricular septal abnormality|Interventricular septal defect,,disease_ontology,,DOID:1657,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,ventricular septal defect,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000387,"[""ROCK1 kinase domain""]",,"Rho-associated protein kinase 1; Rho-associated, coiled-coil containing protein kinase 1; MGC131603; MGC43611; P160ROCK; PRO0435; ROCK1",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Rho-associated protein kinase 1; Rho-associated, coiled-coil containing protein kinase 1; MGC131603; MGC43611; P160ROCK; PRO0435; ROCK1",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000387,,,,,,,,,,,,,,,,,,,200381,,,,,,,,,ROCK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000841,"[""umbilical artery""]",,Either of a pair of arteries that arise from the hypogastric arteries of the mammalian fetus and pass through the umbilical cord to the placenta to which they carry the deoxygenated blood from the fetus.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000573,,,,,,,,Either of a pair of arteries that arise from the hypogastric arteries of the mammalian fetus and pass through the umbilical cord to the placenta to which they carry the deoxygenated blood from the fetus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000841,,,,,,,BrendaTissueOBO,,BTO:0000841,,,,,,,,,,,,,,,,,,,umbilical artery,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100801,"[""Trace amine-associated receptor 1""]",,"A trace amine-associated receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96RJ0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A trace amine-associated receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96RJ0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100801,,,,https://pharos.nih.gov/idg/targets/Q96RJ0,,,,,,,,,,,,,TAAR1,TA1|TAR1|TRAR1,,Q96RJ0,,,,,,,,Trace amine-associated receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2025,"[""gestational choriocarcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3594,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2025,,,,NCI:C4646|SNOMEDCT_US_2016_03_01:417570003|SNOMEDCT_US_2016_03_01:1884006|UMLS_CUI:C0349557|SNOMEDCT_US_2016_03_01:417057000,Gestational choriocarcinoma (morphologic abnormality)|Molar pregnancy with choriocarcinoma (disorder)|Gestational chorionepithelioma,,disease_ontology,,DOID:2025,,,,,,,,,,,,,,,,,,,gestational choriocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003627,"[""annulus fibrosus""]",,A ring of fibrous or fibrocartilaginous tissue (as of an intervertebral disk or surrounding an orifice of the heart).,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000206,,,,,,,,A ring of fibrous or fibrocartilaginous tissue (as of an intervertebral disk or surrounding an orifice of the heart).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003627,,,,,,,BrendaTissueOBO,annulus|anulus|fibrous ring|anulus fibrosus,BTO:0003627,,,,,,,,,,,,,,,,,,,annulus fibrosus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400449,"[""KQT subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400449,,,,,,,,,,,,,,,,,,,,,,,,,,,,KQT subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200426,"[""PKDCC gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400209,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200426,,,,,,,,,,,,,,,,91461,PKDCC,SGK493|VLK,,,,,,,,,,PKDCC gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100052,"[""C-c chemokine receptor type 10""]",,"A C-C chemokine receptor type 10 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46092] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300095,,,,,,,,"A C-C chemokine receptor type 10 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46092] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100052,,,,https://pharos.nih.gov/idg/targets/P46092,,,,,,,,,,,,,CCR10,GPR2,,P46092,,,,,,,,C-c chemokine receptor type 10,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000081,"[""CDK8 kinase domain""]",,Cyclin-dependent kinase 8; cell division protein kinase 8; CDK8; K35; MGC126074; MGC126075,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Cyclin-dependent kinase 8; cell division protein kinase 8; CDK8; K35; MGC126074; MGC126075,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000081,,,,,,,,,,,,,,,,,,,200081,,,,,,,,,CDK8 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217567,"[""NR3C1 gene""]",,"This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_00217474,,,,,,,,"This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217567,,,,,,,,,,,,,,,,2908,NR3C1,GRL,,,,,,,,,,NR3C1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002240,"[""exodermis""]",,A layer of the outer living cortical cells of plants that takes over the functions of the epidermis in roots lacking secondary thickening.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A layer of the outer living cortical cells of plants that takes over the functions of the epidermis in roots lacking secondary thickening.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002240,,,,,,,BrendaTissueOBO,plant hypodermis,BTO:0002240,,,,,,,,,,,,,,,,,,,exodermis,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100037,"[""Type-2 angiotensin II receptor""]",,"An angiotensin II receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P50052] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300023,,,,,,,,"An angiotensin II receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P50052] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100037,,,,https://pharos.nih.gov/idg/targets/P50052,,,,,,,,,,,,,AGTR2,,,P50052,,,,,,,,Type-2 angiotensin II receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003941,"[""MDA-MB-435S cell""]",,"This cell line was originally described as a spindle shaped variant of the parental MDA-MB-435 strain isolated from the pleural effusion of a 31 year old female with metastatic, ductal adenocarcinoma of the breast. However, recent studies have reported that this line is cross-contaminated with is the M14 melanoma line.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"This cell line was originally described as a spindle shaped variant of the parental MDA-MB-435 strain isolated from the pleural effusion of a 31 year old female with metastatic, ductal adenocarcinoma of the breast. However, recent studies have reported that this line is cross-contaminated with is the M14 melanoma line.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003941,,,,,,,BrendaTissueOBO,MDA-MB-435 S cell|MDA-MB-435-S cell,BTO:0003941,,,,,,,,,,,,,,,,,,,MDA-MB-435S cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000366,"[""PKNB(M.tuberculosis) kinase domain""]",,Transmembrane Serine/Threonine-Protein Kinase B; PKNB; Protein Kinase B; STPK B,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Transmembrane Serine/Threonine-Protein Kinase B; PKNB; Protein Kinase B; STPK B,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000366,,,,,,,,,,,,,,,,,,,200349,,,,,,,,,PKNB(M.tuberculosis) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391003,"[""Type III PI4K subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391009,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391003,,,,,,,,,,,,,,,,,,,,,,,,,,,,Type III PI4K subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5583,"[""lung giant cell carcinoma""]",,A lung carcinoma that is located_in large undifferentiated cells.,false,,,http://purl.obolibrary.org/obo/DOID_4556,,,,,,,,A lung carcinoma that is located_in large undifferentiated cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5583,,,DOID:5584,SNOMEDCT_US_2016_03_01:42596004|UMLS_CUI:C0345960|NCI:C4452|NCI:C3779|MESH:D018286|SNOMEDCT_US_2016_03_01:254631008|UMLS_CUI:C0206703,Giant cell carcinoma|Giant cell lung carcinoma,,disease_ontology,,DOID:5583,,,,,,,,,,,,,,,,,,,lung giant cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8869,"[""neuromyelitis optica""]",,A central nervous system disease characterized by inflammation of the optic nerve (optic neuritis) and inflammation of the spinal cord (myelitis).,false,,,http://purl.obolibrary.org/obo/DOID_331,,,,,,,,A central nervous system disease characterized by inflammation of the optic nerve (optic neuritis) and inflammation of the spinal cord (myelitis).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8869,,,,UMLS_CUI:C0027873|ICD9CM:341.0|EFO:0004256|ICD10CM:G36.0|MESH:D009471|SNOMEDCT_US_2016_03_01:25044007|NCI:C84934,Devic's disease|Devic's syndrome,,disease_ontology,,DOID:8869,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,neuromyelitis optica,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400359,"[""Two pore domain potassium channel family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400359,,,,,,,,,,,,,,,,,,,,,,,,,,,,Two pore domain potassium channel family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004876,"[""distal tip""]",,"The reproductive tract in the hermaphroditic nematode has two equivalent gonad arms. As it grows longer, that portion lying closer to the gonopore (vulva or cloaca) is termed the proximal arm, while the distal arm lies further away with the extreme end named the distal tip.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The reproductive tract in the hermaphroditic nematode has two equivalent gonad arms. As it grows longer, that portion lying closer to the gonopore (vulva or cloaca) is termed the proximal arm, while the distal arm lies further away with the extreme end named the distal tip.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004876,mgr,2010-10-12T10:33:18Z,,,,,BrendaTissueOBO,,BTO:0004876,,,,,,,,,,,,,,,,,,,distal tip,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200768,"[""SCTR gene""]",,"A secretin receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47872] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400047,,,,,,,,"A secretin receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47872] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200768,,,,,,,,,,,,,,,,6344,SCTR,,,,,,,,,,,SCTR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100088,"[""Dual specificity protein kinase clk3""]",,"A dual specificity protein kinase CLK3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49761] |dual specificity protein kinase clk3 (CLK3)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300140,,,,,,,,"A dual specificity protein kinase CLK3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49761] |dual specificity protein kinase clk3 (CLK3)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100088,,,,https://pharos.nih.gov/idg/targets/P49761,,,,,,,,,,,,,CLK3,,,P49761,,,,,,,,Dual specificity protein kinase clk3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9923,"[""developmental coordination disorder""]",,A specific developmental disorder that involves disordered motor skills where coordinated muscle movement is impaired.,false,,,http://purl.obolibrary.org/obo/DOID_0060038,,,,,,,,A specific developmental disorder that involves disordered motor skills where coordinated muscle movement is impaired.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9923,,,,SNOMEDCT_US_2016_03_01:192578006|MESH:D019957|UMLS_CUI:C0011757|ICD9CM:315.4|SNOMEDCT_US_2016_03_01:27544004|ICD10CM:F82|NCI:C92561,,,disease_ontology,,DOID:9923,,,,,,,,,,,,,,,,,,,developmental coordination disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2163,"[""nasal cavity disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2825,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2163,,,DOID:4728,SNOMEDCT_US_2016_03_01:195823002|UMLS_CUI:C0339820|NCI:C27102|SNOMEDCT_US_2016_03_01:232359007|SNOMEDCT_US_2016_03_01:232340005,,,disease_ontology,,DOID:2163,,,,,,,,,,,,,,,,,,,nasal cavity disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100547,"[""Dual specificity protein kinase ttk""]",,"dual specificity protein kinase ttk (TTK)  with  no mutation  in a nonphosphorylated state|A dual specificity protein kinase TTK that is encoded in the genome of human. [PMID:20823832, PRO:KER] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300240,,,,,,,,"dual specificity protein kinase ttk (TTK)  with  no mutation  in a nonphosphorylated state|A dual specificity protein kinase TTK that is encoded in the genome of human. [PMID:20823832, PRO:KER] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100547,,,,https://pharos.nih.gov/idg/targets/P33981,,,,,,,,,,,,,TTK,MPS1|MPS1L1,,P33981,,,,,,,,Dual specificity protein kinase ttk,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80131,"[""Apelin-13""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C15855,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80131,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80131,,,,,Apelin-13,,CHEBI:80131,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400517,"[""GABRG1 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400517,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRG1 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200623,"[""OR5F1 gene""]",,"An olfactory receptor 5F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95221] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95221] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200623,,,,,,,,,,,,,,,,338674,OR5F1,,,,,,,,,,,OR5F1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100066,"[""Cyclin-dependent kinase 1""]",,"A cell division protein kinase 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P06493] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300258,,,,,,,,"A cell division protein kinase 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P06493] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100066,,,,https://pharos.nih.gov/idg/targets/P06493,,,,,,,,,,,,,CDK1,CDC2|CDC28A|CDKN1|P34CDC2,,P06493,,,,,,,,Cyclin-dependent kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004771,"[""NPA cell""]",,Papillary thyroid tumor cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003210,,,,,,,,Papillary thyroid tumor cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004771,mgr,2010-10-02T11:01:58Z,,,,,BrendaTissueOBO,,BTO:0004771,,,,,,,,,,,,,,,,,,,NPA cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_7188,"[""autoimmune thyroiditis""]",,An autoimmune disease of endocrine system that involves inflammation located_in thyroid gland caused by the immune system reacting against its own tissues.,false,,,http://purl.obolibrary.org/obo/DOID_0060005,,,,,,,,An autoimmune disease of endocrine system that involves inflammation located_in thyroid gland caused by the immune system reacting against its own tissues.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:7188,,,DOID:0050435,SNOMEDCT_US_2016_03_01:190297000|SNOMEDCT_US_2016_03_01:66944004|UMLS_CUI:C0920350|NCI:C38766|ICD10CM:E06.3|SNOMEDCT_US_2016_03_01:21983002|MESH:D013967,Chronic Lymphocytic Thyroiditis|Lymphocytic Thyroiditis|Hashimoto's Disease|Hashimoto's thyroiditis|Hashimoto's syndrome|Hashimoto thyroiditis,,disease_ontology,,DOID:7188,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,autoimmune thyroiditis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100159,"[""G protein-activated inward rectifier potassium channel 1""]",,"A G protein-activated inward rectifier potassium channel 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48549] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300430,,,,,,,,"A G protein-activated inward rectifier potassium channel 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48549] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100159,,,,https://pharos.nih.gov/idg/targets/P48549,,,,,,,,,,,,,KCNJ3,GIRK1,,P48549,,,,,,,,G protein-activated inward rectifier potassium channel 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200112,"[""GPR137 gene""]",,"An integral membrane protein GPR137 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96N19] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400044,,,,,,,,"An integral membrane protein GPR137 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96N19] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200112,,,,,,,,,,,,,,,,56834,GPR137,C11orf4|GPR137A|TM7SF1L1,,,,,,,,,,GPR137 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060173,"[""Timothy syndrome""]",,"An autosomal dominant disease that is characterized by cardiac, hand/foot, facial, and neurodevelopmental features. The two forms are type 1 (classic) and type 2, a rare form that has_material_basis_in mutations in a transcript variant of CACNA1C on chromosome 12p13.33.",false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,"An autosomal dominant disease that is characterized by cardiac, hand/foot, facial, and neurodevelopmental features. The two forms are type 1 (classic) and type 2, a rare form that has_material_basis_in mutations in a transcript variant of CACNA1C on chromosome 12p13.33.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060173,lschriml,2011-11-08T12:52:33Z,DOID:0110649,OMIM:601005|ICD10CM:G72.3|ORDO:65283|ORDO:768,,,disease_ontology,,DOID:0060173,,,,,,,,,,,,,,,,,,,Timothy syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060178,"[""familial hemiplegic migraine""]",,"A migraine with aura that is characterized by temporary numbness or weakness, often affecting one side of the body (hemiparesis). Additional features of an aura can include difficulty with speech, confusion, and drowsiness.",false,,,http://purl.obolibrary.org/obo/DOID_10024,,,,,,,,"A migraine with aura that is characterized by temporary numbness or weakness, often affecting one side of the body (hemiparesis). Additional features of an aura can include difficulty with speech, confusion, and drowsiness.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060178,lschriml,2011-11-08T02:54:32Z,,OMIM:609634|ICD10CM:G43.8|OMIM:602481|OMIM:300125|OMIM:141500|UMLS_CUI:C0477373|ICD9CM:346.8|ORDO:569|SNOMEDCT_US_2016_03_01:193037008|SNOMEDCT_US_2016_03_01:194493009|OMIM:607516|SNOMEDCT_US_2016_03_01:193040008,,,disease_ontology,,DOID:0060178,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,Xref MGI.,,familial hemiplegic migraine,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060175,"[""succinic semialdehyde dehydrogenase deficiency""]",,A gamma-amino butyric acid metabolism disorder that is characterized by a deficiency of succinic semialdehyde dehydrogenase resulting in elevated levels of gamma-hydroxybutyric acid.,false,,,http://purl.obolibrary.org/obo/DOID_0060176,,,,,,,,A gamma-amino butyric acid metabolism disorder that is characterized by a deficiency of succinic semialdehyde dehydrogenase resulting in elevated levels of gamma-hydroxybutyric acid.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060175,lschriml,2011-11-08T02:02:12Z,,,4-hydroxybutyric aciduria|SSADH|gamma-hydroxybutyric aciduria,,disease_ontology,,DOID:0060175,,,,,,,,,,,,,,,,,,,succinic semialdehyde dehydrogenase deficiency,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060172,"[""juvenile absence epilepsy""]",,An adolescence-adult electroclinical syndrome statring between the age of ten to 17 years characterized by the occurrence of typical absence seizures.,false,,,http://purl.obolibrary.org/obo/DOID_0050705,,,,,,,,An adolescence-adult electroclinical syndrome statring between the age of ten to 17 years characterized by the occurrence of typical absence seizures.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060172,lschriml,2011-11-08T10:42:18Z,,,,,disease_ontology,,DOID:0060172,,,,,,,,,,,,,,,,,,,juvenile absence epilepsy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060176,"[""gamma-amino butyric acid metabolism disorder""]",,An amino acid metabolic disorder characterized by impairment of the GABA catabolic pathway.,false,,,http://purl.obolibrary.org/obo/DOID_9252,,,,,,,,An amino acid metabolic disorder characterized by impairment of the GABA catabolic pathway.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060176,lschriml,2011-11-08T02:02:12Z,,,,,disease_ontology,,DOID:0060176,,,,,,,,,,,,,,,,,,,gamma-amino butyric acid metabolism disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100507,"[""Olfactory receptor 1s2""]",,"An olfactory receptor 1S2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1S2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100507,,,,https://pharos.nih.gov/idg/targets/Q8NGQ3,,,,,,,,,,,,,OR1S2,,,Q8NGQ3,,,,,,,,Olfactory receptor 1s2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200015,"[""ADORA2B gene""]",,"An adenosine receptor A2b that is encoded in the genome of human. [PRO:WCB, UniProtKB:P29275] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400018,,,,,,,,"An adenosine receptor A2b that is encoded in the genome of human. [PRO:WCB, UniProtKB:P29275] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200015,,,,,,,,,,,,,,,,136,ADORA2B,,,,,,,,,,,ADORA2B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000181,"[""[Pyr1]apelin-13""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000181,,,,,,,,,,,,,,,,,,,,,,,,,,,,[Pyr1]apelin-13,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400554,"[""Kv11.1/KCNH2 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400448,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400554,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv11.1/KCNH2 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300254,"[""PITSLRE subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300136,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300254,,,,,,,,,,,,,,,,,,,,,,,,,,,,PITSLRE subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02302006,"[""5-HT7 receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300017,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02302006,,,,,,,,,,,,,,,,,,,,,,,,,,,,5-HT7 receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000461,"[""WNK3 kinase domain""]",,WNK lysine deficient protein kinase 3; PRKWNK3,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,WNK lysine deficient protein kinase 3; PRKWNK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000461,,,,,,,,,,,,,,,,,,,200478,,,,,,,,,WNK3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5432,"[""bladder papillary transitional cell neoplasm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5433,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5432,,,,NCI:C39857|UMLS_CUI:C1511197,urinary bladder Papillary Urothelial neoplasm,,disease_ontology,,DOID:5432,,,,,,,,,,,,,,,,,,,bladder papillary transitional cell neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300516,"[""GABRE sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300516,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRE sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000155,"[""bronchoalveolar lavage""]",,A technique by which cells and fluid from bronchioles and lung alveoli are removed for diagnosis of disease or evaluation of treatment. A bronchoscope is wedged into a bronchus and sterile saline is pumped in and then removed along with the fluid and cells to be analyzed.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A technique by which cells and fluid from bronchioles and lung alveoli are removed for diagnosis of disease or evaluation of treatment. A bronchoscope is wedged into a bronchus and sterile saline is pumped in and then removed along with the fluid and cells to be analyzed.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000155,,,,,,,BrendaTissueOBO,bronchoalveolar lavage fluid|bronchioalveolar lavage fluid|BAL cell|bronchioalveolar lavage,BTO:0000155,,,,,,,,,,,,,,,,,,,bronchoalveolar lavage,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000527,"[""glioblastoma cell""]",,Glioblastoma is a general term for malignant forms of astrocytoma.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000100,,,,,,,,Glioblastoma is a general term for malignant forms of astrocytoma.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000527,,,,,,,BrendaTissueOBO,,BTO:0000527,,,,,,,,,,,,,,,,,,,glioblastoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200438,"[""PRKX gene""]",,"This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. [provided by RefSeq, Feb 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400169,,,,,,,,"This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. [provided by RefSeq, Feb 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200438,,,,,,,,,,,,,,,,5613,PRKX,PKX1,,,,,,,,,,PRKX gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100014,"[""H252 in ABL1(Q252H)-nonphosphorylated""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100014,,,,,,,,,,,,,,,,,,,,,,,,,,,,H252 in ABL1(Q252H)-nonphosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000120,"[""BHK-21 cell""]",,"Syrian hamster kidney BHK-21 is a subclone (clone 13) of the parental line established from the kidneys of five unsexed, one-day-old hamsters in 1961; cells can be used for virus replication studies.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001131,,,,,,,,"Syrian hamster kidney BHK-21 is a subclone (clone 13) of the parental line established from the kidneys of five unsexed, one-day-old hamsters in 1961; cells can be used for virus replication studies.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000120,,,,,,,BrendaTissueOBO,BHK 21 cell|baby hamster kidney cell|BHK-21/C13 cell,BTO:0000120,,,,,,,,,,,,,,,,,,,BHK-21 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3112,"[""papillary adenocarcinoma""]",,"An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which form complex papillary structures and exhibit compressive, destructive growth that replaces the normal tissue.",false,,,http://purl.obolibrary.org/obo/DOID_299,,,,,,,,"An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which form complex papillary structures and exhibit compressive, destructive growth that replaces the normal tissue.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3112,,,DOID:5596,MESH:D000231|NCI:C2853|UMLS_CUI:C0001420|SNOMEDCT_US_2016_03_01:4797003|SNOMEDCT_US_2016_03_01:64524002|UMLS_CUI:C1321863|SNOMEDCT_US_2016_03_01:189621008|NCI:C7438,Papillary adenocarcinoma (morphologic abnormality)|Infiltrating and papillary adenocarcinoma|infiltrating papillary adenocarcinoma|Papillary adenocarcinoma NOS (morphologic abnormality)|Papillary adenocarcinoma,,disease_ontology,,DOID:3112,,,,,,,,,,,,,,,,,,,papillary adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100281,"[""Mitogen-activated protein kinase kinase kinase 15""]",,"mitogen-activated protein kinase kinase kinase 15 (MAP3K15)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase kinase kinase 15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6ZN16] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300186,,,,,,,,"mitogen-activated protein kinase kinase kinase 15 (MAP3K15)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase kinase kinase 15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6ZN16] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100281,,,,https://pharos.nih.gov/idg/targets/Q6ZN16,,,,,,,,,,,,,MAP3K15,ASK3,,Q6ZN16,,,,,,,,Mitogen-activated protein kinase kinase kinase 15,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300198,"[""NRBP family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300198,,,,,,,,,,,,,,,,,,,,,,,,,,,,NRBP family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200372,"[""OR2T29 gene""]",,"An olfactory receptor 2T29 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH02] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2T29 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH02] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200372,,,,,,,,,,,,,,,,343563,OR2T29,,,,,,,,,,,OR2T29 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200443,"[""PTK7 gene""]",,"This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400214,,,,,,,,"This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200443,,,,,,,,,,,,,,,,5754,PTK7,CCK4,,,,,,,,,,PTK7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11054,"[""urinary bladder cancer""]",,An urinary system cancer that results_in malignant growth located_in the urinary bladder.,false,,,http://purl.obolibrary.org/obo/DOID_3996|http://purl.obolibrary.org/obo/DOID_365,,,,,,,,An urinary system cancer that results_in malignant growth located_in the urinary bladder.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11054,,,DOID:5428,MESH:D001749|ICD9CM:188|UMLS_CUI:C0005684|UMLS_CUI:C0005695|SNOMEDCT_US_2016_03_01:154540000|KEGG:05219|SNOMEDCT_US_2016_03_01:269607003|ICD9CM:188.9|NCI:C9334|ICD10CM:C67.9|SNOMEDCT_US_2016_03_01:188248005|OMIM:109800|SNOMEDCT_US_2016_03_01:363455001|NCI:C2901|SNOMEDCT_US_2016_03_01:126885006|SNOMEDCT_US_2016_03_01:399326009|ICD10CM:C67|SNOMEDCT_US_2016_03_01:93689003,tumor of the bladder|bladder cancer,,disease_ontology,,DOID:11054,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,urinary bladder cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000096,"[""Annexin I""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000096,,,,,,,,,,,,,,,,,,,,,,,,,,,,Annexin I,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050904,"[""salivary gland carcinoma""]",,A salivary gland cancer that has_material_basis_in epithelial cells.,false,,,http://purl.obolibrary.org/obo/DOID_8850|http://purl.obolibrary.org/obo/DOID_305,,,,,,,,A salivary gland cancer that has_material_basis_in epithelial cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050904,lschriml,2014-10-08T16:52:58Z,,,,,disease_ontology,,DOID:0050904,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,salivary gland carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050909,"[""MALT lymphoma""]",,A non-Hodgkin lymphoma that has_material_basis_in mucosal tissue involved in antibody production.,false,,,http://purl.obolibrary.org/obo/DOID_0060060,,,,,,,,A non-Hodgkin lymphoma that has_material_basis_in mucosal tissue involved in antibody production.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050909,lschriml,2014-10-13T14:17:40Z,,,mucosa-associated lymphoid tissue lymphoma,,disease_ontology,,DOID:0050909,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,MALT lymphoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050902,"[""medulloblastoma""]",,An infratentorial cancer that is located_in the lower part of the brain and is a type of primitive neuroectodermal tumor.,false,,,http://purl.obolibrary.org/obo/DOID_4706,,,,,,,,An infratentorial cancer that is located_in the lower part of the brain and is a type of primitive neuroectodermal tumor.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050902,lschriml,2014-10-06T14:36:37Z,DOID:168|DOID:0060105|DOID:3858|DOID:4981,MESH:D008527|SNOMEDCT_US_2016_03_01:189925001|UMLS_CUI:C0206663|SNOMEDCT_US_2016_03_01:443333004|MESH:D018242|SNOMEDCT_US_2016_03_01:83217000|UMLS_CUI:C0025149|UMLS_CUI:C1334410|NCI:C3222|SNOMEDCT_US_2016_03_01:189933000|NCI:C27294|NCI:C3716|SNOMEDCT_US_2016_03_01:699028006|SNOMEDCT_US_2016_03_01:39781001|SNOMEDCT_US_2016_03_01:55045006|OMIM:155255|SNOMEDCT_US_2016_03_01:189921005,CPNET|CNS PNET|brain medulloblastoma|localized primitive neuroectodermal tumor|infratentorial primitive neuroectodermal tumor ,,disease_ontology,,DOID:0050902,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,medulloblastoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050908,"[""myelodysplastic syndrome""]",,"A bone marrow cancer that is characterized by under production of white blood cells, red blood cells and platelets.",false,,,http://purl.obolibrary.org/obo/DOID_4960,,,,,,,,"A bone marrow cancer that is characterized by under production of white blood cells, red blood cells and platelets.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050908,lschriml,2014-10-13T12:51:33Z,,UMLS_CUI:C2713368|ICD9:238.7|MESH:D009190|OMIM:614286,,,disease_ontology,,DOID:0050908,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,myelodysplastic syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000101,"[""MET1079 in IGF1R""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000101,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET1079 in IGF1R,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000406,"[""SGK2 kinase domain""]",,Serine/threonine-protein kinase Sgk2; Serum/glucocorticoid-regulated kinase 2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase Sgk2; Serum/glucocorticoid-regulated kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000406,,,,,,,,,,,,,,,,,,,201108,,,,,,,,,SGK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002606,"[""glial cell""]",,As glia they build the delicate network of branched cells and fibers that supports the tissue of the central nervous system.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,As glia they build the delicate network of branched cells and fibers that supports the tissue of the central nervous system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002606,Marion,2010-01-28T08:55:00Z,,,,,BrendaTissueOBO,neuroglia cell|glia cell|neuroglial cell,BTO:0002606,,,,,,,,,,,,,,,,,,,glial cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000975,"[""ovary""]",,One of the typically paired essential female reproductive organs that produce eggs and in vertebrates female sex hormones.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000254|http://purl.obolibrary.org/obo/BTO_0003099|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,,One of the typically paired essential female reproductive organs that produce eggs and in vertebrates female sex hormones.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000975,,,,,,,BrendaTissueOBO,,BTO:0000975,,,,,,,,,,,,,,,,,,,ovary,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002515,"[""brain cortex cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0000255|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002515,,,,,,,BrendaTissueOBO,brain cortical cell line|cerebral cortex cell line,BTO:0002515,,,,,,,,,,,,,,,,,,,brain cortex cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200011,"[""ACVRL1 gene""]",,"This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400246,,,,,,,,"This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200011,,,,,,,,,,,,,,,,94,ACVRL1,ACVRLK1|ALK1,,,,,,,,,,ACVRL1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000389,"[""THR711 in EPHB3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000389,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR711 in EPHB3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200388,"[""PAK6 gene""]",,"This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400304,,,,,,,,"This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200388,,,,,,,,,,,,,,,,56924,PAK6,PAK5,,,,,,,,,,PAK6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400366,"[""Mechanical nociceptor, piezo (piezo) family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400366,,,,,,,,,,,,,,,,,,,,,,,,,,,,"Mechanical nociceptor, piezo (piezo) family gene",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200402,"[""OR51L1 gene""]",,"An olfactory receptor 51L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 51L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200402,,,,,,,,,,,,,,,,119682,OR51L1,,,,,,,,,,,OR51L1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004774,"[""trophoblast stem cell""]",,Tanaka et al have reported that a culture of mouse blastocysts or early postimplantation trophoblasts in the presence of FGF-4 permits the isolation of permanent trophoblast stem cell lines.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Tanaka et al have reported that a culture of mouse blastocysts or early postimplantation trophoblasts in the presence of FGF-4 permits the isolation of permanent trophoblast stem cell lines.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004774,mgr,2010-10-02T11:14:22Z,,,,,BrendaTissueOBO,TS cell,BTO:0004774,,,,,,,,,,,,,,,,,,,trophoblast stem cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000966,"[""optic nerve""]",,The optic nerve is the nerve that connects the eye to the brain and carries the impulses formed by the retina to the visual cortex of the brain.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The optic nerve is the nerve that connects the eye to the brain and carries the impulses formed by the retina to the visual cortex of the brain.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000966,,,,,,,BrendaTissueOBO,,BTO:0000966,,,,,,,,,,,,,,,,,,,optic nerve,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100281,"[""Polycystic kidney disease and receptor for egg jelly-related protein""]",,"A polycystic kidney disease and receptor for egg jelly-related protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NTG1] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300367,,,,,,,,"A polycystic kidney disease and receptor for egg jelly-related protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NTG1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100281,,,,https://pharos.nih.gov/idg/targets/Q9NTG1,,,,,,,,,,,,,PKDREJ,,,Q9NTG1,,,,,,,,Polycystic kidney disease and receptor for egg jelly-related protein,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100459,"[""Olfactory receptor 6c70""]",,"An olfactory receptor 6C70 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NIJ9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6C70 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NIJ9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100459,,,,https://pharos.nih.gov/idg/targets/A6NIJ9,,,,,,,,,,,,,OR6C70,,,A6NIJ9,,,,,,,,Olfactory receptor 6c70,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100335,"[""Dual specificity mitogen-activated protein kinase kinase 2""]",,"dual specificity mitogen-activated protein kinase kinase 2 (MP2K2)  with  no mutation  in a nonphosphorylated state|A dual specificity mitogen-activated protein kinase kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P36507] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300194,,,,,,,,"dual specificity mitogen-activated protein kinase kinase 2 (MP2K2)  with  no mutation  in a nonphosphorylated state|A dual specificity mitogen-activated protein kinase kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P36507] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100335,,,,https://pharos.nih.gov/idg/targets/P36507,,,,,,,,,,,,,MAP2K2,MEK2|MKK2|PRKMK2,,P36507,,,,,,,,Dual specificity mitogen-activated protein kinase kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000227,"[""central nervous system""]",,The central nervous system is that part of the nervous system that consists of the brain and spinal cord. The central nervous system (CNS) is one of the two major divisions of the nervous system. The other is the peripheral nervous system (PNS) which is outside the brain and spinal cord.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The central nervous system is that part of the nervous system that consists of the brain and spinal cord. The central nervous system (CNS) is one of the two major divisions of the nervous system. The other is the peripheral nervous system (PNS) which is outside the brain and spinal cord.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000227,,,,,,,BrendaTissueOBO,neuraxis|CNS|cerebrospinal axis,BTO:0000227,,,,,,,,,,,,,,,,,,,central nervous system,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000180,"[""cervical carcinoma cell""]",,A cancer cell of the uterine cervix (the neck of the uterus).,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A cancer cell of the uterine cervix (the neck of the uterus).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000180,,,,,,,BrendaTissueOBO,"uterine cervix carcinoma cell|carcinoma cell, cervical|cervix carcinoma cell|cervix cancer cell|cervical cancer cell",BTO:0000180,,,,,,,,,,,,,,,,,,,cervical carcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4971,"[""myelofibrosis""]",,A myeloid neoplasm that is located_in the bone marrow which results_in bone marrow being replaced by fibrous (scar) tissue.,false,,,http://purl.obolibrary.org/obo/DOID_0070004,,,,,,,,A myeloid neoplasm that is located_in the bone marrow which results_in bone marrow being replaced by fibrous (scar) tissue.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4971,,,DOID:5737,ICD10CM:D47.4|SNOMEDCT_US_2016_03_01:22265001|UMLS_CUI:C0001815|ICD10CM:D75.81|SNOMEDCT_US_2016_03_01:154841009|SNOMEDCT_US_2016_03_01:307651005|OMIM:254450|SNOMEDCT_US_2016_03_01:128843003|MESH:D055728|NCI:C3248|SNOMEDCT_US_2016_03_01:267572005|SNOMEDCT_US_2016_03_01:188773009|UMLS_CUI:C0026987|SNOMEDCT_US_2016_03_01:78956007|SNOMEDCT_US_2016_03_01:52967002|ICD9CM:289.83|NCI:C2862|ICD9CM:238.76,myelosclerosis|bone Marrow Fibrosis|Aleukemic myelosis|primary myelofibrosis|Megakaryocytic myelosclerosis|Agnogenic myeloid metaplasia,,disease_ontology,,DOID:4971,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,myelofibrosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100501,"[""Serine/threonine-protein kinase 33""]",,"A serine/threonine-protein kinase 33 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BYT3] |serine/threonine-protein kinase 33 (STK33)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300135,,,,,,,,"A serine/threonine-protein kinase 33 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BYT3] |serine/threonine-protein kinase 33 (STK33)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100501,,,,https://pharos.nih.gov/idg/targets/Q9BYT3,,,,,,,,,,,,,STK33,,,Q9BYT3,,,,,,,,Serine/threonine-protein kinase 33,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8488,"[""polyhydramnios""]",,A placenta disease that is characterized by an excess of amniotic fluid in the amniotic sac.,false,,,http://purl.obolibrary.org/obo/DOID_780,,,,,,,,A placenta disease that is characterized by an excess of amniotic fluid in the amniotic sac.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8488,,,,ICD9CM:657.0|SNOMEDCT_US_2016_03_01:199645005|UMLS_CUI:C0020224|SNOMEDCT_US_2016_03_01:157052008|SNOMEDCT_US_2016_03_01:156188008|NCI:C92848|ICD10CM:O40|SNOMEDCT_US_2016_03_01:199648007|SNOMEDCT_US_2016_03_01:86203003|ICD9CM:657|SNOMEDCT_US_2016_03_01:405235009|SNOMEDCT_US_2016_03_01:199644009|MESH:D006831|SNOMEDCT_US_2016_03_01:199650004|SNOMEDCT_US_2016_03_01:267261001,,,disease_ontology,,DOID:8488,,,,,,,,,,,,,,,,,,,polyhydramnios,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100083,"[""Chloride intracellular channel protein 5""]",,"A chloride intracellular channel protein 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZA1] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300342,,,,,,,,"A chloride intracellular channel protein 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZA1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100083,,,,https://pharos.nih.gov/idg/targets/Q9NZA1,,,,,,,,,,,,,CLIC5,,,Q9NZA1,,,,,,,,Chloride intracellular channel protein 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3602,"[""toxic encephalopathy""]",,"A nervous system disease that results from exposure to neurotoxicants and is characterized by an altered mental status, memory loss, and visual problems.",false,,,http://purl.obolibrary.org/obo/DOID_863,,,,,,,,"A nervous system disease that results from exposure to neurotoxicants and is characterized by an altered mental status, memory loss, and visual problems.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3602,,,,SNOMEDCT_US_2016_03_01:19466003|NCI:C27961|MESH:D020258|UMLS_CUI:C0235032,neurotoxicity|neurotoxicity syndrome,,disease_ontology,,DOID:3602,,,,,,,,,,,,,,,,,,,toxic encephalopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200437,"[""OR52Z1 gene""]",,"An olfactory receptor 52Z1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C646] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 52Z1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C646] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200437,,,,,,,,,,,,,,,,283110,OR52Z1,OR52Z1P,,,,,,,,,,OR52Z1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000356,"[""THR442 in TEC""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000356,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR442 in TEC,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100032,"[""L317 in ABL1(F317L)-phosphorylated""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100032,,,,,,,,,,,,,,,,,,,,,,,,,,,,L317 in ABL1(F317L)-phosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117477,"[""Germ cell nuclear factor receptors""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00102000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117477,,,,,,,,,,,,,,,,,,,,,,,,,,,,Germ cell nuclear factor receptors,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200746,"[""PTGER4 gene""]",,"A prostaglandin E2 receptor EP4 subtype that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35408] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A prostaglandin E2 receptor EP4 subtype that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35408] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200746,,,,,,,,,,,,,,,,5734,PTGER4,PTGER2,,,,,,,,,,PTGER4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200561,"[""OR3A1 gene""]",,"An olfactory receptor 3A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47881] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 3A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47881] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200561,,,,,,,,,,,,,,,,4994,OR3A1,OLFRA03,,,,,,,,,,OR3A1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8125,"[""osteochondrosis""]",,An ischemic bone disease that results_in necrosis followed by regrowth in children and teens located_in bone.,false,,,http://purl.obolibrary.org/obo/DOID_0080008,,,,,,,,An ischemic bone disease that results_in necrosis followed by regrowth in children and teens located_in bone.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8125,,,DOID:7490,SNOMEDCT_US_2016_03_01:268125000|UMLS_CUI:C0158445|SNOMEDCT_US_2016_03_01:156822009|UMLS_CUI:C0029429|MESH:D055034|NCI:C34879|ICD9CM:732.6|SNOMEDCT_US_2016_03_01:65477003|SNOMEDCT_US_2016_03_01:19579005|SNOMEDCT_US_2016_03_01:123256004|ICD10CM:M93.9|SNOMEDCT_US_2016_03_01:203398006|ICD10CM:M92,"osteochondritis juvenilis|(Osteochondrosis NOS) or (apophysitis NOS) or (epiphysitis NOS) or (osteochondritis NOS)|Epiphyseal necrosis, NOS|Osteochondrosis not specified as adult or juvenile, of unspecified site",,disease_ontology,,DOID:8125,,,,,,,,,,,,,,,,,,,osteochondrosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004528,"[""high endothelial venule""]",,"Specialized area of vascular endothelium found in lymphoid organs, which express a variety of cell-adhesion molecules and is involved in lymphocyte extravasation.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Specialized area of vascular endothelium found in lymphoid organs, which express a variety of cell-adhesion molecules and is involved in lymphocyte extravasation.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004528,mgr,2010-02-13T05:53:27Z,,,,,BrendaTissueOBO,HEV cell,BTO:0004528,,,,,,,,,,,,,,,,,,,high endothelial venule,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300237,"[""TRBL family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300237,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRBL family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3962,"[""follicular thyroid carcinoma""]",,A thyroid carcinoma that has_material_basis_in follicular cells.,false,,,http://purl.obolibrary.org/obo/DOID_3963|http://purl.obolibrary.org/obo/DOID_299,,,,,,,,A thyroid carcinoma that has_material_basis_in follicular cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3962,,,,SNOMEDCT_US_2016_03_01:28173006|MESH:D018263|UMLS_CUI:C0206682|SNOMEDCT_US_2016_03_01:255028004|OMIM:188470|NCI:C8054|SNOMEDCT_US_2016_03_01:189642005|SNOMEDCT_US_2016_03_01:5257006,"Follicular carcinoma|Thyroid adenocarcinoma|Follicular thyroid carcinoma (disorder)|Follicular adenocarcinoma (morphologic abnormality)|Follicular carcinoma of the Thyroid gland|Follicular adenocarcinoma, well differentiated (morphologic abnormality)",,disease_ontology,,DOID:3962,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,follicular thyroid carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200354,"[""NEK11 gene""]",,"This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400197,,,,,,,,"This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200354,,,,,,,,,,,,,,,,79858,NEK11,,,,,,,,,,,NEK11 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9741,"[""biliary tract disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3118,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9741,,,,SNOMEDCT_US_2016_03_01:155830002|SNOMEDCT_US_2016_03_01:155832005|MESH:D001660|UMLS_CUI:C0005424|ICD9CM:576.9|SNOMEDCT_US_2016_03_01:5235004|SNOMEDCT_US_2016_03_01:105997008|SNOMEDCT_US_2016_03_01:266545005|SNOMEDCT_US_2016_03_01:266544009|ICD10CM:K83.9,,,disease_ontology,,DOID:9741,,,,,,,,,,,,,,,,,,,biliary tract disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300528,"[""GLRA4 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300409,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300528,,,,,,,,,,,,,,,,,,,,,,,,,,,,GLRA4 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002774,"[""amyloid plaque""]",,A plaque consisting of tangles of amyloid protein in nervous tissue (a pathological mark of Alzheimer's disease).,false,,,http://purl.obolibrary.org/obo/BTO_0000590|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A plaque consisting of tangles of amyloid protein in nervous tissue (a pathological mark of Alzheimer's disease).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002774,,,,,,,BrendaTissueOBO,,BTO:0002774,,,,,,,,,,,,,,,,,,,amyloid plaque,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000164,"[""MET366 in PRKR""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000164,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET366 in PRKR,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200250,"[""MCOLN2 gene""]",,"Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 [PubMed 17662026]).[supplied by OMIM, Sep 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400575,,,,,,,,"Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 [PubMed 17662026]).[supplied by OMIM, Sep 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200250,,,,,,,,,,,,,,,,255231,MCOLN2,,,,,,,,,,,MCOLN2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200753,"[""PTAFR gene""]",,"A platelet-activating factor receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25105] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A platelet-activating factor receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25105] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200753,,,,,,,,,,,,,,,,5724,PTAFR,PAFR,,,,,,,,,,PTAFR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001286,"[""skin cancer cell""]",,"The two most common forms of skin cancer are basal cell carcinoma and squamous cell carcinoma. Together, these two are also referred to as nonmelanoma skin cancer. Melanoma is generally the most serious form of skin cancer because it tends to spread (metastasize) throughout the body quickly.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The two most common forms of skin cancer are basal cell carcinoma and squamous cell carcinoma. Together, these two are also referred to as nonmelanoma skin cancer. Melanoma is generally the most serious form of skin cancer because it tends to spread (metastasize) throughout the body quickly.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001286,,,,,,,BrendaTissueOBO,skin carcinoma cell,BTO:0001286,,,,,,,,,,,,,,,,,,,skin cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000179,"[""SRIF-14""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000179,,,,,,,,,,,,,,,,,,,,,,,,,,,,SRIF-14,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100181,"[""Probable g-protein coupled receptor 19""]",,"A G-protein coupled receptor 19 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15760] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 19 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15760] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100181,,,,https://pharos.nih.gov/idg/targets/Q15760,,,,,,,,,,,,,GPR19,,,Q15760,,,,,,,,Probable g-protein coupled receptor 19,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100012,"[""F253 in ABL1(Y253F)-phosphorylated""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100012,,,,,,,,,,,,,,,,,,,,,,,,,,,,F253 in ABL1(Y253F)-phosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400445,"[""KCNE subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400445,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNE subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400405,"[""CNGA4 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400343,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400405,,,,,,,,,,,,,,,,,,,,,,,,,,,,CNGA4 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000315,"[""NEK5 kinase domain""]",,NIMA (never in mitosis gene a)-related kinase 5; MGC75495; NEK5,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,NIMA (never in mitosis gene a)-related kinase 5; MGC75495; NEK5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000315,,,,,,,,,,,,,,,,,,,200291,,,,,,,,,NEK5 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001764,"[""neural crest""]",,"The part of the ectoderm in a vertebrate embryo that lies on either side of the neural tube and develops into the cranial, spinal, and autonomic ganglia.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The part of the ectoderm in a vertebrate embryo that lies on either side of the neural tube and develops into the cranial, spinal, and autonomic ganglia.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001764,,,,,,,BrendaTissueOBO,,BTO:0001764,,,,,,,,,,,,,,,,,,,neural crest,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400230,"[""TK-UNIQUE family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400230,,,,,,,,,,,,,,,,,,,,,,,,,,,,TK-UNIQUE family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003009,"[""NCI-H1703 cell""]",,Non-small cell lung cancer cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002553,,,,,,,,Non-small cell lung cancer cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003009,,,,,,,BrendaTissueOBO,H-1703 cell|H1703 cell,BTO:0003009,,,,,,,,,,,,,,,,,,,NCI-H1703 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001166,"[""renal cortex""]",,Cortex of kidney.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Cortex of kidney.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001166,,,,,,,BrendaTissueOBO,kidney cortex,BTO:0001166,,,,,,,,,,,,,,,,,,,renal cortex,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100413,"[""Olfactory receptor 52B6""]",,"An olfactory receptor 52B6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 52B6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100413,,,,https://pharos.nih.gov/idg/targets/Q8NGF0,,,,,,,,,,,,,OR52B6,,,Q8NGF0,,,,,,,,Olfactory receptor 52B6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4989,"[""pancreatitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_26,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4989,,,,ICD10CM:K85.9|SNOMEDCT_US_2016_03_01:393591004|EFO:0000278|SNOMEDCT_US_2016_03_01:75694006|NCI:C3306|SNOMEDCT_US_2016_03_01:197461009|UMLS_CUI:C0030305|MESH:D010195,,,disease_ontology,,DOID:4989,,,,,,,,,,,,,,,,,,,pancreatitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100133,"[""Glutamate receptor 1""]",,"A glutamate receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42261] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300410,,,,,,,,"A glutamate receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42261] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100133,,,,https://pharos.nih.gov/idg/targets/P42261,,,,,,,,,,,,,GRIA1,GLUH1|GLUR1,,P42261,,,,,,,,Glutamate receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1679,"[""cystitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_365,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1679,,,,MESH:D003556|UMLS_CUI:C0010692|SNOMEDCT_US_2016_03_01:197857009|SNOMEDCT_US_2016_03_01:155882000|ICD9CM:595|ICD10CM:N30.9|SNOMEDCT_US_2016_03_01:155885003|ICD9CM:595.9|ICD10CM:N30|SNOMEDCT_US_2016_03_01:266629000|SNOMEDCT_US_2016_03_01:38822007|NCI:C26738,,,disease_ontology,,DOID:1679,,,,,,,,,,,,,,,,,,,cystitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117480,"[""Thyroid hormone receptor alpha""]",,"A thyroid hormone receptor alpha that is encoded in the genome of human. [PRO:HJD, UniProtKB:P10827] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117460,,,,,,,,"A thyroid hormone receptor alpha that is encoded in the genome of human. [PRO:HJD, UniProtKB:P10827] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117480,,,,https://pharos.nih.gov/idg/targets/P10827,,,,,,,,,,,,,THRA,ERBA1,,P10827,,,,,,,,Thyroid hormone receptor alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_15553,"[""prostaglandin F2alpha""]","Dinoprost|C20H34O5|Enzaprost F|PGF2alpha|PXGPLTODNUVGFL-YNNPMVKQSA-N|InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1|(5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate|U 14583|9a,11a-PGF2|dinoprosta|9,11,15-Trihydroxy-(5Z,9a,11a,13E,15S)-prosta-5,13-dien-1-oic acid|dinoprost|CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O|l-Prostaglandin F2-alpha|Cyclosin|354.48100|Prostaglandin F2a|7-[3,5-Dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl]-5-heptenoic acid|dinoprostum|l-PGF2-alpha|PGF2a|Enzaprost|0|354.241|Protamodin|(+)-Prostaglandin F2a|Amoglandin|Panacelan|Prostin F 2 alpha","A prostaglandins Falpha that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15. It is a naturally occurring prostaglandin used to induce labor.",false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,Drug_Central:912|Reaxys:2225571|PMID:11438482|Wikipedia:Dinoprost|MetaCyc:5Z13E-15S-9-ALPHA11-ALPHA15-TRIHY|Beilstein:2225571|KEGG:D00081|LIPID_MAPS_instance:LMFA03010002|HMDB:HMDB01139|CAS:551-11-1|PMID:23807981|KEGG:C00639,"A prostaglandins Falpha that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15. It is a naturally occurring prostaglandin used to induce labor.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:26327|CHEBI:8516|CHEBI:10913,,"Prostaglandin F2alpha|(5Z,13E,15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dien-1-oic acid",,chebi_ontology,"Dinoprost|C20H34O5|Enzaprost F|PGF2alpha|PXGPLTODNUVGFL-YNNPMVKQSA-N|InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1|(5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate|U 14583|9a,11a-PGF2|dinoprosta|9,11,15-Trihydroxy-(5Z,9a,11a,13E,15S)-prosta-5,13-dien-1-oic acid|dinoprost|CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O|l-Prostaglandin F2-alpha|Cyclosin|354.48100|Prostaglandin F2a|7-[3,5-Dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl]-5-heptenoic acid|dinoprostum|l-PGF2-alpha|PGF2a|Enzaprost|0|354.241|Protamodin|(+)-Prostaglandin F2a|Amoglandin|Panacelan|Prostin F 2 alpha",,,CHEBI:15553,,,,,,,,,,,,,,,,,,,,,,,CHEBI:15553,,,,,prostaglandin F2alpha,,CHEBI:15553,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400543,"[""Kv3.3/KCNC3 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400443,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400543,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv3.3/KCNC3 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001235,"[""seminiferous tubule""]",,"One of two or three twisted, curved tubules in each lobule of the testis in which spermatozoa develop.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"One of two or three twisted, curved tubules in each lobule of the testis in which spermatozoa develop.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001235,,,,,,,BrendaTissueOBO,,BTO:0001235,,,,,,,,,,,,,,,,,,,seminiferous tubule,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001006,"[""pelvis""]",,"The inferior portion of the trunk of the body, bounded anteriorly and laterally by the two hip bones and posteriorly by the sacrum and coccyx. The pelvis is divided by a plane passing through the terminal lines into the pelvis major superiorly and the pelvis minor inferiorly.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The inferior portion of the trunk of the body, bounded anteriorly and laterally by the two hip bones and posteriorly by the sacrum and coccyx. The pelvis is divided by a plane passing through the terminal lines into the pelvis major superiorly and the pelvis minor inferiorly.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001006,,,,,,,BrendaTissueOBO,,BTO:0001006,,,,,,,,,,,,,,,,,,,pelvis,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000233,"[""cerebral cortex""]",,The surface layer of gray matter of the cerebrum that functions chiefly in coordination of sensory and motor information.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The surface layer of gray matter of the cerebrum that functions chiefly in coordination of sensory and motor information.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000233,,,,,,,BrendaTissueOBO,pallium of the brain|brain cortex|cortex of cerebral hemisphere,BTO:0000233,,,,,,,,,,,,,,,,,,,cerebral cortex,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100237,"[""Potassium voltage-gated channel subfamily S member 1""]",,"A voltage-gated potassium channel KCNS1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q96KK3] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300566,,,,,,,,"A voltage-gated potassium channel KCNS1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q96KK3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100237,,,,https://pharos.nih.gov/idg/targets/Q96KK3,,,,,,,,,,,,,KCNS1,,,Q96KK3,,,,,,,,Potassium voltage-gated channel subfamily S member 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300289,"[""MAPKAPK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300188,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300289,,,,,,,,,,,,,,,,,,,,,,,,,,,,MAPKAPK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000372,"[""bone cancer cell""]",,"Cancer cell of the skeleton. Cancers that begin in bone are rare but it is not unusual for cancers to spread (metastasize) to bone from other parts of the body. This is not called bone cancer, but is named for the organ or tissue in which the cancer begins.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Cancer cell of the skeleton. Cancers that begin in bone are rare but it is not unusual for cancers to spread (metastasize) to bone from other parts of the body. This is not called bone cancer, but is named for the organ or tissue in which the cancer begins.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000372,,,,,,,BrendaTissueOBO,bone tumor cell,BTO:0000372,,,,,,,,,,,,,,,,,,,bone cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000853,"[""mesangial cell""]",,"Cell found within the glomerular lobules of mammalian kidney, where they serve as structural supports, may regulate blood flow, are phagocytic, and may act as accessory cells, presenting antigen in immune responses.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Cell found within the glomerular lobules of mammalian kidney, where they serve as structural supports, may regulate blood flow, are phagocytic, and may act as accessory cells, presenting antigen in immune responses.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000853,,,,,,,BrendaTissueOBO,glomerular mesangial cell,BTO:0000853,,,,,,,,,,,,,,,,,,,mesangial cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200135,"[""GRIA3 gene""]",,"Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA-&gt;GGA; R-&gt;G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400412,,,,,,,,"Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA-&gt;GGA; R-&gt;G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200135,,,,,,,,,,,,,,,,2892,GRIA3,GLUR3|GLURC,,,,,,,,,,GRIA3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100306,"[""Olfactory receptor 10g9""]",,"An olfactory receptor 10G9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10G9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100306,,,,https://pharos.nih.gov/idg/targets/Q8NGN4,,,,,,,,,,,,,OR10G9,OR10G10P,,Q8NGN4,,,,,,,,Olfactory receptor 10g9,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001157,"[""rectal gland""]",,"An evagination of the terminal portion of the intestine of Elasmobranchii. Function formerly thought to be related to digestion or excretion, but now considered to secrete high concentrations of excess sodium chloride. Found also in the coelacanth Latimeria chalumnae.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"An evagination of the terminal portion of the intestine of Elasmobranchii. Function formerly thought to be related to digestion or excretion, but now considered to secrete high concentrations of excess sodium chloride. Found also in the coelacanth Latimeria chalumnae.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001157,,,,,,,BrendaTissueOBO,,BTO:0001157,,,,,,,,,,,,,,,,,,,rectal gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200140,"[""GRIK2 gene""]",,"Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400417,,,,,,,,"Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200140,,,,,,,,,,,,,,,,2898,GRIK2,GLUR6,,,,,,,,,,GRIK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300271,"[""GRK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300127,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300271,,,,,,,,,,,,,,,,,,,,,,,,,,,,GRK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100658,"[""Olfactory receptor 6c6""]",,"An olfactory receptor 6C6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NF89] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6C6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NF89] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100658,,,,https://pharos.nih.gov/idg/targets/A6NF89,,,,,,,,,,,,,OR6C6,,,A6NF89,,,,,,,,Olfactory receptor 6c6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100617,"[""Olfactory receptor 5B21""]",,"An olfactory receptor 5B21 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NL26] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5B21 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NL26] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100617,,,,https://pharos.nih.gov/idg/targets/A6NL26,,,,,,,,,,,,,OR5B21,,,A6NL26,,,,,,,,Olfactory receptor 5B21,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003994,"[""hoof""]",,A hoofed foot especially of a horse.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000476,,,,,,,,A hoofed foot especially of a horse.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003994,,,,,,,BrendaTissueOBO,,BTO:0003994,,,,,,,,,,,,,,,,,,,hoof,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02302007,"[""Lysophospholipid (LPA) receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02302007,,,,,,,,,,,,,,,,,,,,,,,,,,,,Lysophospholipid (LPA) receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12361,"[""Graves' disease""]",,"An autoimmune disease of endocrine system that involves production of excessive amount of thyroid hormones, located_in thyroid gland.",false,,,http://purl.obolibrary.org/obo/DOID_0060005,,,,,,,,"An autoimmune disease of endocrine system that involves production of excessive amount of thyroid hormones, located_in thyroid gland.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12361,,,,SNOMEDCT_US_2016_03_01:237823003|SNOMEDCT_US_2016_03_01:190240002|OMIM:300351|OMIM:603388|MESH:D006111|SNOMEDCT_US_2016_03_01:353295004|SNOMEDCT_US_2016_03_01:267464006|EFO:0004237|ICD10CM:E05.0|SNOMEDCT_US_2016_03_01:154655004|NCI:C3071|OMIM:275000|SNOMEDCT_US_2016_03_01:237510004|UMLS_CUI:C0018213|SNOMEDCT_US_2016_03_01:367449005|SNOMEDCT_US_2016_03_01:367367004|SNOMEDCT_US_2016_03_01:55807009|SNOMEDCT_US_2016_03_01:38591003,exophthalmic goiter|Grave's disease|Graves disease,,disease_ontology,Basedow's disease,DOID:12361,,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,Graves' disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12365,"[""malaria""]",,"A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle.",false,,,http://purl.obolibrary.org/obo/DOID_2789,,,,,,,,"A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12365,,,DOID:12552,SNOMEDCT_US_2016_03_01:105649009|SNOMEDCT_US_2016_03_01:154374002|ICD10CM:B54|ICD9CM:084|MESH:D008288|OMIM:609148|UMLS_CUI:C0024530|NCI:C34797|EFO:0001068|SNOMEDCT_US_2016_03_01:186797008|SNOMEDCT_US_2016_03_01:248437004|ICD9CM:084.6|SNOMEDCT_US_2016_03_01:61462000|SNOMEDCT_US_2016_03_01:187510004,induced malaria,,disease_ontology,,DOID:12365,,,,,,,,,,,,,,,,,Xref MGI.,,malaria,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100106,"[""Frizzled-4""]",,"A frizzled-4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9ULV1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300043,,,,,,,,"A frizzled-4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9ULV1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100106,,,,https://pharos.nih.gov/idg/targets/Q9ULV1,,,,,,,,,,,,,FZD4,,,Q9ULV1,,,,,,,,Frizzled-4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9362,"[""status asthmaticus""]",,"An asthma that is a life threatening condition with progressive respiratory failure, which does not respond to standard treatment.",false,,,http://purl.obolibrary.org/obo/DOID_2841,,,,,,,,"An asthma that is a life threatening condition with progressive respiratory failure, which does not respond to standard treatment.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9362,,,,SNOMEDCT_US_2016_03_01:195980003|SNOMEDCT_US_2016_03_01:266363006|SNOMEDCT_US_2016_03_01:36979006|SNOMEDCT_US_2016_03_01:708090002|SNOMEDCT_US_2016_03_01:155577001|ICD9CM:493.91|UMLS_CUI:C0038218|MESH:D013224|NCI:C122577|SNOMEDCT_US_2016_03_01:57546000,Asthma with status asthmaticus|Severe asthma attack,,disease_ontology,,DOID:9362,,,,,,,,,,,,,,,,,,,status asthmaticus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200024,"[""ANO6 gene""]",,"This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400329,,,,,,,,"This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200024,,,,,,,,,,,,,,,,196527,ANO6,TMEM16F,,,,,,,,,,ANO6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000090,"[""MET102 in MAPKAPK5""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000090,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET102 in MAPKAPK5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200416,"[""OR52E2 gene""]",,"An olfactory receptor 52E2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 52E2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200416,,,,,,,,,,,,,,,,119678,OR52E2,,,,,,,,,,,OR52E2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200103,"[""FZD1 gene""]",,"A frizzled-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UP38] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400043,,,,,,,,"A frizzled-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UP38] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200103,,,,,,,,,,,,,,,,8321,FZD1,,,,,,,,,,,FZD1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001862,"[""nucleus accumbens""]",,A nucleus forming the floor of the caudal part of the anterior prolongation of the lateral ventricle of the brain.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A nucleus forming the floor of the caudal part of the anterior prolongation of the lateral ventricle of the brain.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001862,,,,,,,BrendaTissueOBO,accumbens nucleus|nucleus accumbens septi|colliculus of caudate nucleus,BTO:0001862,,,,,,,,,,,,,,,,,,,nucleus accumbens,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491015,"[""Thymidine kinase family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400322,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491015,,,,,,,,,,,,,,,,,,,,,,,,,,,,Thymidine kinase family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000097,"[""F2L""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000097,,,,,,,,,,,,,,,,,,,,,,,,,,,,F2L,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400126,"[""RAF family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400107,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400126,,,,,,,,,,,,,,,,,,,,,,,,,,,,RAF family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300563,"[""Kv7.3/KCNQ3 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300449,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300563,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv7.3/KCNQ3 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1091,"[""tooth disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_403,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1091,,,,SNOMEDCT_US_2016_03_01:234947003|SNOMEDCT_US_2016_03_01:367503003|SNOMEDCT_US_2016_03_01:155631000|SNOMEDCT_US_2016_03_01:266485001|UMLS_CUI:C0040435|SNOMEDCT_US_2016_03_01:72722003|MESH:D014076,dental disorder,,disease_ontology,,DOID:1091,,,,,,,,,,,,,,,,,,,tooth disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10915,"[""Wernicke-Korsakoff syndrome""]",,OMIM mapping confirmed by DO. [LS].,false,,,http://purl.obolibrary.org/obo/DOID_5113,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10915,,,,UMLS_CUI:C0349464|SNOMEDCT_US_2016_03_01:191472007|NCI:C84803|SNOMEDCT_US_2016_03_01:154854002|MESH:D020915|SNOMEDCT_US_2016_03_01:69482004|OMIM:277730|SNOMEDCT_US_2016_03_01:191470004|SNOMEDCT_US_2016_03_01:268745002|NCI:C35764,Korsakov psychosis|Korsakoff's psychosis (disorder)|Korsakoff Syndrome|Korsakoff's syndrome|Korsakov's psychosis,,disease_ontology,,DOID:10915,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,Wernicke-Korsakoff syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10919,"[""transsexualism""]",,A gender identity disorder that is characterized by an individual's identification with a gender inconsistent or not culturally associated with their biological sex.,false,,,http://purl.obolibrary.org/obo/DOID_1234,,,,,,,,A gender identity disorder that is characterized by an individual's identification with a gender inconsistent or not culturally associated with their biological sex.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10919,,,,SNOMEDCT_US_2016_03_01:191782007|ICD9CM:302.50|UMLS_CUI:C0040630,,,disease_ontology,,DOID:10919,,,,,,,,,,,,,,,,,,,transsexualism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10914,"[""amnestic disorder""]",,"A cognitive disorder where the memory is disturbed or lost and involves the loss of memories previously established, loss of the ability to create new memories, or loss of the ability to learn new information.",false,,,http://purl.obolibrary.org/obo/DOID_1561,,,,,,,,"A cognitive disorder where the memory is disturbed or lost and involves the loss of memories previously established, loss of the ability to create new memories, or loss of the ability to learn new information.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10914,,,DOID:4544,MESH:D000647|SNOMEDCT_US_2016_03_01:386807006|NCI:C2867|SNOMEDCT_US_2016_03_01:48167000|ICD10CM:R41.3|UMLS_CUI:C0002622|SNOMEDCT_US_2016_03_01:3298001|SNOMEDCT_US_2016_03_01:247606008|SNOMEDCT_US_2016_03_01:162199006|UMLS_CUI:C0002625|ICD9CM:294.0|SNOMEDCT_US_2016_03_01:78461004,amnesia|Korsakoff's psychosis or syndrome|Amnestic syndrome,,disease_ontology,,DOID:10914,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,amnestic disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100724,"[""2-oxoglutarate receptor 1""]",,"A 2-oxoglutarate receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P68] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A 2-oxoglutarate receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P68] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100724,,,,https://pharos.nih.gov/idg/targets/Q96P68,,,,,,,,,,,,,OXGR1,GPR80|GPR99|P2RY15|P2Y15,,Q96P68,,,,,,,,2-oxoglutarate receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300568,"[""Kv9.3/KCNS3 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300450,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300568,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv9.3/KCNS3 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005493,"[""Mv1Lu cell""]",,"Mink fetal lung cell line, derived from trypsinised lungs of several foetuses of Aleutian mink.",false,,,http://purl.obolibrary.org/obo/BTO_0000353|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Mink fetal lung cell line, derived from trypsinised lungs of several foetuses of Aleutian mink.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005493,XPMUser,2013-09-11T09:11:37Z,,,,,BrendaTissueOBO,Mv.1.Lu cell|NBL-7 cell|Mv 1 Lu cell,BTO:0005493,,,,,,,,,,,,,,,,,,,Mv1Lu cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200469,"[""OPRK1 gene""]",,"A kappa-type opioid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41145] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A kappa-type opioid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41145] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200469,,,,,,,,,,,,,,,,4986,OPRK1,OPRK,,,,,,,,,,OPRK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2468,"[""psychotic disorder""]",,A cognitive disorder that involves abnormal thinking and perceptions resulting in a disconnection with reality.,false,,,http://purl.obolibrary.org/obo/DOID_1561,,,,,,,,A cognitive disorder that involves abnormal thinking and perceptions resulting in a disconnection with reality.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2468,,,,ICD9CM:298.8|EFO:0000677|UMLS_CUI:C0029516,mental or behavioural disorder,,disease_ontology,,DOID:2468,,,,,,,,,,,,,,,,,,,psychotic disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100084,"[""Chloride intracellular channel protein 6""]",,"A chloride intracellular channel protein 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96NY7] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300342,,,,,,,,"A chloride intracellular channel protein 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96NY7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100084,,,,https://pharos.nih.gov/idg/targets/Q96NY7,,,,,,,,,,,,,CLIC6,CLIC1L,,Q96NY7,,,,,,,,Chloride intracellular channel protein 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200457,"[""ROCK2 gene""]",,"The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400313,,,,,,,,"The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200457,,,,,,,,,,,,,,,,9475,ROCK2,KIAA0619,,,,,,,,,,ROCK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000158,"[""FGFR1 kinase domain""]",,Fibroblast growth factor receptor 1; BFGFR; CD331; CEK; FGFBR; FGFR1; FLG; FLJ99988; FLT2; HBGFR; KAL2; N-SAM; OGD,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Fibroblast growth factor receptor 1; BFGFR; CD331; CEK; FGFBR; FGFR1; FLG; FLJ99988; FLT2; HBGFR; KAL2; N-SAM; OGD,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000158,,,,,,,,,,,,,,,,,,,200161,,,,,,,,,FGFR1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000294,"[""PHE91 in CDK7""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000294,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE91 in CDK7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100228,"[""Mevalonate kinase""]",,"A mevalonate kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q03426] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391007,,,,,,,,"A mevalonate kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q03426] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100228,,,,https://pharos.nih.gov/idg/targets/Q03426,,,,,,,,,,,,,MVK,,,Q03426,,,,,,,,Mevalonate kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200262,"[""MRGPRX2 gene""]",,"A mas-related G-protein coupled receptor X2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96LB1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400063,,,,,,,,"A mas-related G-protein coupled receptor X2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96LB1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200262,,,,,,,,,,,,,,,,117194,MRGPRX2,MRGX2,,,,,,,,,,MRGPRX2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200626,"[""TBCK gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200626,,,,,,,,,,,,,,,,,,,,,,,,,,,,TBCK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8719,"[""in situ carcinoma""]",,A carcinoma that is an early development defined by the absence of invasion of surrounding tissues.,false,,,http://purl.obolibrary.org/obo/DOID_0060071,,,,,,,,A carcinoma that is an early development defined by the absence of invasion of surrounding tissues.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8719,,,DOID:8793|DOID:8821,SNOMEDCT_US_2016_03_01:109355002|ICD9CM:234.9|ICD10CM:D09.9|SNOMEDCT_US_2016_03_01:189208007|SNOMEDCT_US_2016_03_01:189359006|UMLS_CUI:C0007099|SNOMEDCT_US_2016_03_01:189548003|SNOMEDCT_US_2016_03_01:68956006|NCI:C2917|ICD9CM:230-234.99|SNOMEDCT_US_2016_03_01:271528002|SNOMEDCT_US_2016_03_01:154635000|MESH:D002278|SNOMEDCT_US_2016_03_01:399919001|SNOMEDCT_US_2016_03_01:154640008,,,disease_ontology,,DOID:8719,,,,,,,,,,,,,,,,,,,in situ carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400290,"[""MARK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400116,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400290,,,,,,,,,,,,,,,,,,,,,,,,,,,,MARK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100146,"[""Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3""]",,"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9P1Z3] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300343,,,,,,,,"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9P1Z3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100146,,,,https://pharos.nih.gov/idg/targets/Q9P1Z3,,,,,,,,,,,,,HCN3,KIAA1535,,Q9P1Z3,,,,,,,,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400560,"[""Kv12.1/KCNH8 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400448,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400560,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv12.1/KCNH8 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200011,"[""CHRNA6 gene""]",,"This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence. [provided by RefSeq, Dec 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400495,,,,,,,,"This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence. [provided by RefSeq, Dec 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200011,,,,,,,,,,,,,,,,8973,CHRNA6,,,,,,,,,,,CHRNA6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9574,"[""choanal atresia""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_2163,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9574,,,DOID:14713,OMIM:608911|UMLS_CUI:C0220723|SNOMEDCT_US_2016_03_01:204508009|SNOMEDCT_US_2016_03_01:204514002|ICD9CM:748.0|SNOMEDCT_US_2016_03_01:156934002|ICD10CM:Q30.0|MESH:D002754|UMLS_CUI:C0008297|SNOMEDCT_US_2016_03_01:14988006|SNOMEDCT_US_2016_03_01:53458004|SNOMEDCT_US_2016_03_01:204509001|MESH:C562435,Atresia of nares|posterior choanal atresia|Imperforate nares,,disease_ontology,,DOID:9574,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,choanal atresia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4450,"[""renal cell carcinoma""]",,A renal carcinoma that has_material_basis_in the lining of the proximal convoluted renal tubule of the kidney.,false,,,http://purl.obolibrary.org/obo/DOID_4451|http://purl.obolibrary.org/obo/DOID_299,,,,,,,,A renal carcinoma that has_material_basis_in the lining of the proximal convoluted renal tubule of the kidney.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4450,,,,SNOMEDCT_US_2016_03_01:254915003|UMLS_CUI:C0007134|SNOMEDCT_US_2016_03_01:41607009|EFO:0000681|NCI:C9385|MESH:D002292|OMIM:300854|SNOMEDCT_US_2016_03_01:702391001,hypernephroma|adenocarcinoma of kidney|RCC,,disease_ontology,,DOID:4450,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,Xref MGI.,,renal cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100044,"[""Bone morphogenetic protein receptor type-1a""]",,"bone morphogenetic protein receptor type-1a (BMPR1A)  with  no mutation  in a nonphosphorylated state|A BMP receptor type-1A that is encoded in the genome of human. [PRO:CNA, UniProtKB:P36894] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300246,,,,,,,,"bone morphogenetic protein receptor type-1a (BMPR1A)  with  no mutation  in a nonphosphorylated state|A BMP receptor type-1A that is encoded in the genome of human. [PRO:CNA, UniProtKB:P36894] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100044,,,,https://pharos.nih.gov/idg/targets/P36894,,,,,,,,,,,,,BMPR1A,ACVRLK3|ALK3,,P36894,,,,,,,,Bone morphogenetic protein receptor type-1a,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_7319,"[""axonal neuropathy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_870,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:7319,,,,UMLS_CUI:C0270921|NCI:C27301|SNOMEDCT_US_2016_03_01:60703000,,,disease_ontology,,DOID:7319,,,,,,,,,,,,,,,,,,,axonal neuropathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000664,"[""K-562 cell""]",,Human chronic myeloid leukemia in blast crisis established from the pleural effusion of a 53-year-old woman with chronic myeloid leukemia (CML) in blast crisis in 1970.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002580,,,,,,,,Human chronic myeloid leukemia in blast crisis established from the pleural effusion of a 53-year-old woman with chronic myeloid leukemia (CML) in blast crisis in 1970.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000664,,,,,,,BrendaTissueOBO,K-562/S cell|K562s cell|K562 cell|K562wt cell,BTO:0000664,,,,,,,,,,,,,,,,,,,K-562 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005441,"[""lateral root""]",,"Lateral roots extend horizontally from the primary root (radicle) and serve to anchor the plant securely into the soil. This branching of roots also contributes to water uptake, and facilitates the extraction of nutrients required for the growth and development of the plant.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001188,,,,,,,,"Lateral roots extend horizontally from the primary root (radicle) and serve to anchor the plant securely into the soil. This branching of roots also contributes to water uptake, and facilitates the extraction of nutrients required for the growth and development of the plant.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005441,XPMUser,2013-04-23T11:36:51Z,,,,,BrendaTissueOBO,,BTO:0005441,,,,,,,,,,,,,,,,,,,lateral root,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000460,"[""WNK1 kinase domain""]",,WNK lysine deficient protein kinase 1; KDP; PSK; p65; HSN2; HSAN2; PRKWNK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,WNK lysine deficient protein kinase 1; KDP; PSK; p65; HSN2; HSAN2; PRKWNK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000460,,,,,,,,,,,,,,,,,,,200477,,,,,,,,,WNK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001593,"[""osteoblast""]",,A cell from which bone develops; a bone-forming cell.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002050,,,,,,,,A cell from which bone develops; a bone-forming cell.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001593,,,,,,,BrendaTissueOBO,,BTO:0001593,,,,,,,,,,,,,,,,,,,osteoblast,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000282,"[""head""]",,"The upper or anterior division of the animal body that contains the brain, the chief sense organs, and the mouth.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,,"The upper or anterior division of the animal body that contains the brain, the chief sense organs, and the mouth.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000282,,,,,,,BrendaTissueOBO,,BTO:0000282,,,,,,,,,,,,,,,,,,,head,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200231,"[""KIT gene""]",,"This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400141,,,,,,,,"This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200231,,,,,,,,,,,,,,,,3815,KIT,SCFR,,,,,,,,,,KIT gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100383,"[""Olfactory receptor 4F21""]",,"An olfactory receptor 4F21 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95013] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4F21 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95013] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100383,,,,https://pharos.nih.gov/idg/targets/O95013,,,,,,,,,,,,,OR4F21,OR4F21P,,O95013,,,,,,,,Olfactory receptor 4F21,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400384,"[""CACNA1D subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400333,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400384,,,,,,,,,,,,,,,,,,,,,,,,,,,,CACNA1D subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000182,"[""HASP kinase domain""]",,Serine/threonine-protein kinase haspin; germ cell associated 2 (haspin); GSG2; HASPIN,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase haspin; germ cell associated 2 (haspin); GSG2; HASPIN,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000182,,,,,,,,,,,,,,,,,,,200473,,,,,,,,,HASP kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001685,"[""aortic smooth muscle""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0001431|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001685,,,,,,,BrendaTissueOBO,aorta smooth muscle|aortic vascular smooth muscle,BTO:0001685,,,,,,,,,,,,,,,,,,,aortic smooth muscle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100063,"[""CD97 antigen""]",,"A CD97 molecule that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48960] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,"A CD97 molecule that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48960] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100063,,,,https://pharos.nih.gov/idg/targets/P48960,,,,,,,,,,,,,CD97,ADGRE5,,P48960,,,,,,,,CD97 antigen,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003234,"[""FTO-2B cell""]",,Rat hepatoma cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0000578|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Rat hepatoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003234,,,,,,,BrendaTissueOBO,FTO2B cell,BTO:0003234,,,,,,,,,,,,,,,,,,,FTO-2B cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005415,"[""gastroduodenal mucosa""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000886,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005415,XPMUser,2012-09-20T11:38:47Z,,,,,BrendaTissueOBO,,BTO:0005415,,,,,,,,,,,,,,,,,,,gastroduodenal mucosa,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300156,"[""FAST family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300108,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300156,,,,,,,,,,,,,,,,,,,,,,,,,,,,FAST family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400444,"[""D (Shal) subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400444,,,,,,,,,,,,,,,,,,,,,,,,,,,,D (Shal) subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200449,"[""OR5AL1 gene""]",,"An olfactory receptor 5AL1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C617] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5AL1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C617] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200449,,,,,,,,,,,,,,,,79482,OR5AL1,OR5AL1P,,,,,,,,,,OR5AL1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200198,"[""GPR45 gene""]",,"A G-protein coupled receptor 45 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5Y3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 45 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5Y3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200198,,,,,,,,,,,,,,,,11250,GPR45,,,,,,,,,,,GPR45 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8549,"[""chronic ulcer of skin""]",,,false,,,http://purl.obolibrary.org/obo/DOID_37,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8549,,,DOID:8733|DOID:8548,SNOMEDCT_US_2016_03_01:156426001|SNOMEDCT_US_2016_03_01:19429009|UMLS_CUI:C0157738|ICD9CM:707|SNOMEDCT_US_2016_03_01:156423009|SNOMEDCT_US_2016_03_01:201259007|ICD10CM:L98.4,Callous ulcer (morphologic abnormality)|Indolent ulcer (morphologic abnormality),,disease_ontology,,DOID:8549,,,,,,,,,,,,,,,,,,,chronic ulcer of skin,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200024,"[""CHRM4 gene""]",,"A muscarinic acetylcholine receptor M4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08173] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400020,,,,,,,,"A muscarinic acetylcholine receptor M4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08173] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200024,,,,,,,,,,,,,,,,1132,CHRM4,,,,,,,,,,,CHRM4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003461,"[""HT-1376 cell""]",,"Human urinary bladder carcinoma cell line; established from a transurethral resection of invasive, moderately pleomorphic (grade 3) bladder transitional cell carcinoma of a 58-year-old Caucasian woman who had not received chemo- or radiotherapy.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000792,,,,,,,,"Human urinary bladder carcinoma cell line; established from a transurethral resection of invasive, moderately pleomorphic (grade 3) bladder transitional cell carcinoma of a 58-year-old Caucasian woman who had not received chemo- or radiotherapy.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003461,,,,,,,BrendaTissueOBO,HT1376 cell,BTO:0003461,,,,,,,,,,,,,,,,,,,HT-1376 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/UBERON_0000473,"[""testis""]",testiculus|orchis|testes,"gonad of a male animal, produces and releases sperm.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062|http://purl.obolibrary.org/obo/BTO_0003096|http://purl.obolibrary.org/obo/BTO_0000534,,,,,,,http://linkedlifedata.com/resource/umls/id/C0039597|http://en.wikipedia.org/wiki/Testis|http://www.snomedbrowser.com/Codes/Details/181431007|MA:0000411|MESH:A05.360.444.849|EHDAA:8146|ZFA:0000598|ncithesaurus:Testis|TAO:0000598|BSA:0000085|WBbt:0006794|BTO:0001363|EHDAA2:0002007|FBbt:00004928|galen:Testis|MIAA:0000132|FMA:7210|BILA:0000124|EMAPA:17972|EFO:0000984|OpenCyc:Mx4rvVjM25wpEbGdrcN5Y29ycA|UMLS:C0039597|XAO:0000157|VHOG:0000252|HAO:0001007|CALOHA:TS-1030|AAO:0000606|EV:0100102|GAID:396|MAT:0000132,"gonad of a male animal, produces and releases sperm.",,http://upload.wikimedia.org/wikipedia/commons/thumb/c/c3/Gray1144.png/200px-Gray1144.png,,,,,,,,Male reproductive organ.[TAO]|Either of paired male reproductive organs which are involved in the production of sperm and male sex hormones.[AAO],,,,,,,,,,,,,,,,,,,,,,,,UBERON:0002117,,genitalia of male organism gonada|testicle|gonad of male genitalia|genitalia of male organism gonad|gonada of male reproductive system|gonada of male genitals|reproductive system of male organism gonada|gonad of reproductive system of male organism|male reproductive system gonada|gonad of male organism reproductive system|male genitalia gonada|male gonad|male genitals gonad|male reproductive system gonad|male organism reproductive system gonada|gonada of reproductive system of male organism|gonad of male genitals|reproductive system of male organism gonad|gonada of genitalia of male organism|gonada of male organism genitalia|gonad of male reproductive system|gonad of male organism genitalia|male organism reproductive system gonad|male organism genitalia gonad|gonada of male genitalia|gonada of male organism reproductive system|male organism genitalia gonada|gonad of genitalia of male organism|male genitalia gonad,,uberon,testiculus|orchis|testes,testicular," (...) while it is likely that Urbilateria lacked a complex somatic reproductive system, it is at present impossible to speculate on whether or not it possessed a true gonad, let alone any other somatic adaptations for reproduction (reference 1); Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved (reference 2).[uncertain][VHOG]",,,,,,,,,,,,,,,,,,,,,,,,UBERON:0000473,,,,,testis,,UBERON:0000473,,http://purl.obolibrary.org/obo/uberon.owl,http://purl.obolibrary.org/obo/uberon/core#efo_slim|http://purl.obolibrary.org/obo/uberon/core#organ_slim|http://purl.obolibrary.org/obo/uberon/core#vertebrate_core|http://purl.obolibrary.org/obo/uberon/core#uberon_slim,,,,,,,,,,,,,,,,,,,,,,The testes are descended in metatherian and eutherian mammals.,,
http://purl.obolibrary.org/obo/BTO_0002605,"[""TE-671 cell""]",,"Human rhabdomyosarcoma cell line. In the original publication and in the ATCC catalogue this cell line is described as medulloblastoma; recent studies and the characterization carried out at the DSMZ indicated that TE-671 are muscle cells, most likely identical to the rhabdomyosarcoma cell line RD (also known as TE32 or 130T).",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002267,,,,,,,,"Human rhabdomyosarcoma cell line. In the original publication and in the ATCC catalogue this cell line is described as medulloblastoma; recent studies and the characterization carried out at the DSMZ indicated that TE-671 are muscle cells, most likely identical to the rhabdomyosarcoma cell line RD (also known as TE32 or 130T).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002605,,,,,,,BrendaTissueOBO,TE671 cell,BTO:0002605,,,,,,,,,,,,,,,,,,,TE-671 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000315,"[""THR266 in CSK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000315,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR266 in CSK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5453,"[""pulmonary venoocclusive disease""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_6432,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5453,,,,NCI:C85039|OMIM:265450|UMLS_CUI:C0034091|MESH:D011668|SNOMEDCT_US_2016_03_01:89420002,pulmonary veno-occlusive disease (disorder),,disease_ontology,,DOID:5453,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,pulmonary venoocclusive disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10863,"[""paralytic squint""]",,,false,,,http://purl.obolibrary.org/obo/DOID_540,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10863,,,,ICD9CM:378.50|SNOMEDCT_US_2016_03_01:400942002|SNOMEDCT_US_2016_03_01:194120005|SNOMEDCT_US_2016_03_01:194117002|SNOMEDCT_US_2016_03_01:12942001|ICD10CM:H49.9|ICD9CM:378.5|UMLS_CUI:C0152221|ICD10CM:H49,Incomitant dissociation|Paralytic strabismus,,disease_ontology,,DOID:10863,,,,,,,,,,,,,,,,,,,paralytic squint,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000173,"[""fruit capsule""]",,"A simple fruit that develops from a compound ovary with two or more carpels; capsules dehisce in many ways, example: cotton.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000486|http://purl.obolibrary.org/obo/BTO_0001287,,,,,,,,"A simple fruit that develops from a compound ovary with two or more carpels; capsules dehisce in many ways, example: cotton.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000173,,,,,,,BrendaTissueOBO,plant capsule,BTO:0000173,,,,,,,,,,,,,,,,,,,fruit capsule,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100129,"[""Ephrin type-a receptor 5""]",,"An ephrin type-A receptor 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54756] |ephrin type-a receptor 5 (EPHA5)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300153,,,,,,,,"An ephrin type-A receptor 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54756] |ephrin type-a receptor 5 (EPHA5)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100129,,,,https://pharos.nih.gov/idg/targets/P54756,,,,,,,,,,,,,EPHA5,BSK|EHK1|HEK7|TYRO4,,P54756,,,,,,,,Ephrin type-a receptor 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1070,"[""primary open angle glaucoma""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_1067,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1070,,,,SNOMEDCT_US_2016_03_01:77075001|SNOMEDCT_US_2016_03_01:155122001|NCI:C35394|ICD10CM:H40.11|MESH:C562750|OMIM:137760|UMLS_CUI:C0339573|ICD9CM:365.11,chronic simple glaucoma,,disease_ontology,,DOID:1070,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,primary open angle glaucoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200201,"[""KCNG1 gene""]",,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This gene is abundantly expressed in skeletal muscle. Multiple alternatively spliced transcript variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400549,,,,,,,,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This gene is abundantly expressed in skeletal muscle. Multiple alternatively spliced transcript variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200201,,,,,,,,,,,,,,,,3755,KCNG1,,,,,,,,,,,KCNG1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62200000,"[""phosphorylated residue""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_33700,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62200000,,,,,,,,,,,,,,,,,,,,,,,,,,,,phosphorylated residue,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000032,"[""ACVRL1 kinase domain""]",,Activin A receptor type II-like 1; ACVRL1; ACVRLK1; ALK1; ALK-1; HHT; HHT2; ORW2; SKR3; TSR-I,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Activin A receptor type II-like 1; ACVRL1; ACVRLK1; ALK1; ALK-1; HHT; HHT2; ORW2; SKR3; TSR-I,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000032,,,,,,,,,,,,,,,,,,,200031,,,,,,,,,ACVRL1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200144,"[""GPR135 gene""]",,"A G-protein coupled receptor 135 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8IZ08] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400037,,,,,,,,"A G-protein coupled receptor 135 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8IZ08] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200144,,,,,,,,,,,,,,,,64582,GPR135,,,,,,,,,,,GPR135 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000286,"[""PHE80 in CDKL2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000286,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE80 in CDKL2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000340,"[""PIK3C2G kinase domain""]",,"Phosphoinositide-3-kinase, class 2, gamma polypeptide; MGC163149; PI3K-C2GAMMA; PIK3C2G",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Phosphoinositide-3-kinase, class 2, gamma polypeptide; MGC163149; PI3K-C2GAMMA; PIK3C2G",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000340,,,,,,,,,,,,,,,,,,,200322,,,,,,,,,PIK3C2G kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200172,"[""HIPK1 gene""]",,"The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400273,,,,,,,,"The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200172,,,,,,,,,,,,,,,,204851,HIPK1,KIAA0630|MYAK|NBAK2,,,,,,,,,,HIPK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13911,"[""achromatopsia""]",,"A color blindness that is characterized by a congenital cone color vision disorder, the inability to perceive color and to achieve satisfactory visual acuity at high light levels has_material_basis_in autosomal recessive inheritance.",false,,,http://purl.obolibrary.org/obo/DOID_13399,,,,,,,,"A color blindness that is characterized by a congenital cone color vision disorder, the inability to perceive color and to achieve satisfactory visual acuity at high light levels has_material_basis_in autosomal recessive inheritance.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13911,,,,NCI:C84528|ICD9CM:368.54|MESH:D003117|ICD10CM:H53.51|ORDO:49382|UMLS_CUI:C0152200|SNOMEDCT_US_2016_03_01:56852002,Monochromatism|ACHM,,disease_ontology,,DOID:13911,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,achromatopsia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13910,"[""red color blindness""]",,,false,,,http://purl.obolibrary.org/obo/DOID_13399,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13910,,,,ICD9CM:368.51|SNOMEDCT_US_2016_03_01:51445007|ICD10CM:H53.54|OMIM:303900|MESH:D003117|UMLS_CUI:C0155015,Protan defect|Protanopia,,disease_ontology,,DOID:13910,,,,,,,,,,,,,,,,,,,red color blindness,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000950,"[""Novikoff hepatoma cell""]",,Novikoff hepatoma has been induced by feeding 4-dimethylaminoazobenzene to a male rat.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000608,,,,,,,,Novikoff hepatoma has been induced by feeding 4-dimethylaminoazobenzene to a male rat.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000950,,,,,,,BrendaTissueOBO,,BTO:0000950,,,,,,,,,,,,,,,,,,,Novikoff hepatoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000013,"[""CCL17""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000013,,,,,,,,,,,,,,,,,,,,,,,,,,,,CCL17,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1142,"[""alternating exotropia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1143,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1142,,,,SNOMEDCT_US_2016_03_01:37214009|UMLS_CUI:C0152207|MESH:D005099|ICD10CM:H50.15|ICD9CM:378.15|SNOMEDCT_US_2016_03_01:194093000,,,disease_ontology,,DOID:1142,,,,,,,,,,,,,,,,,,,alternating exotropia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050936,"[""extra-adrenal pheochromocytoma""]",,An adrenal medulla cancer that originate in the ganglia of the sympathetic nervous system and are named based upon the primary anatomical site of origin.,false,,,http://purl.obolibrary.org/obo/DOID_5719,,,,,,,,An adrenal medulla cancer that originate in the ganglia of the sympathetic nervous system and are named based upon the primary anatomical site of origin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050936,lschriml,2014-10-22T10:25:45Z,,,,,disease_ontology,,DOID:0050936,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,extra-adrenal pheochromocytoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400308,"[""PLK2 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400211,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400308,,,,,,,,,,,,,,,,,,,,,,,,,,,,PLK2 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100018,"[""Adenosine kinase""]",,"An adenosine kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P55263] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300322,,,,,,,,"An adenosine kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P55263] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100018,,,,https://pharos.nih.gov/idg/targets/P55263,,,,,,,,,,,,,ADK,,,P55263,,,,,,,,Adenosine kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200716,"[""OR9G9 gene""]",,"An olfactory receptor 9G9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7N8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 9G9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7N8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200716,,,,,,,,,,,,,,,,504191,OR9G9,,,,,,,,,,,OR9G9 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200234,"[""PHKA1 gene""]",,"Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the skeletal muscle isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9D, also known as X-linked muscle glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. A pseudogene has been found on chromosome 1.[provided by RefSeq, Feb 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03491039,,,,,,,,"Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the skeletal muscle isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9D, also known as X-linked muscle glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. A pseudogene has been found on chromosome 1.[provided by RefSeq, Feb 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200234,,,,,,,,,,,,,,,,5255,PHKA1,PHKA,,,,,,,,,,PHKA1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003604,"[""renal parenchyma""]",,"The functional tissue of the kidney, consisting of the nephrons.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The functional tissue of the kidney, consisting of the nephrons.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003604,Marion,2010-01-29T11:24:56Z,,,,,BrendaTissueOBO,kidney parenchyma,BTO:0003604,,,,,,,,,,,,,,,,,,,renal parenchyma,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300587,"[""TRPM5 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300483,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300587,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPM5 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_7400,"[""Nijmegen breakage syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050737,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:7400,,,,UMLS_CUI:C0398791|OMIM:251260|NCI:C4692|SNOMEDCT_US_2016_03_01:234638009|MESH:D049932,"Berlin breakage syndrome|Seemanova syndrome|Microcephaly, normal intelligence and immunodeficiency (disorder)",,disease_ontology,,DOID:7400,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Nijmegen breakage syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6217,"[""gastric diffuse adenocarcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3717,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6217,,,DOID:4946,UMLS_CUI:C0334280|NCI:C4127|UMLS_CUI:C0279635|SNOMEDCT_US_2016_03_01:24505004|NCI:C9159,"diffuse type carcinoma|adenocarcinoma of Linitis Plastica type|carcinoma, diffuse type (morphologic abnormality)|Diffuse type adenocarcinoma",,disease_ontology,,DOID:6217,,,,,,,,,,,,,,,,,,,gastric diffuse adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2055,"[""post-traumatic stress disorder""]",,An anxiety disorder which results from a traumatic experience that results in psychological trauma.,false,,,http://purl.obolibrary.org/obo/DOID_2030,,,,,,,,An anxiety disorder which results from a traumatic experience that results in psychological trauma.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2055,,,,ICD9CM:309.81|UMLS_CUI:C0038436|ICD10CM:F43.10|NCI:C3389|SNOMEDCT_US_2016_03_01:47505003|ICD10CM:F43.1|MESH:D013313|SNOMEDCT_US_2016_03_01:192415000,traumatic neurosis,,disease_ontology,post-traumatic stress disorder,DOID:2055,,,,,,,,,,,,,,,,,,,post-traumatic stress disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000159,"[""bulb""]",,"A resting stage of a plant (as the lily, onion, hyacinth, or tulip) that is usually formed underground and consists of a short stem base bearing one or more buds enclosed in overlapping membranous or fleshy leaves.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000720,,,,,,,,"A resting stage of a plant (as the lily, onion, hyacinth, or tulip) that is usually formed underground and consists of a short stem base bearing one or more buds enclosed in overlapping membranous or fleshy leaves.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000159,,,,,,,BrendaTissueOBO,,BTO:0000159,,,,,,,,,,,,,,,,,,,bulb,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400461,"[""RYR2 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400354,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400461,,,,,,,,,,,,,,,,,,,,,,,,,,,,RYR2 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001483,"[""WiDr cell""]",,"Human, colon, adenocarcinoma cell line.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001913,,,,,,,,"Human, colon, adenocarcinoma cell line.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001483,,,,,,,BrendaTissueOBO,,BTO:0001483,,,,,,,,,,,,,,,,,,,WiDr cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200370,"[""OR2T12 gene""]",,"An olfactory receptor 2T12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG77] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2T12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG77] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200370,,,,,,,,,,,,,,,,127064,OR2T12,,,,,,,,,,,OR2T12 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400413,"[""GRIA4 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400413,,,,,,,,,,,,,,,,,,,,,,,,,,,,GRIA4 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000379,"[""embryo""]",,"An animal in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems; especially: the developing human individual from the time of implantation to the end of the eighth week after conception.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000174,,,,,,,,"An animal in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems; especially: the developing human individual from the time of implantation to the end of the eighth week after conception.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000379,,,,,,,BrendaTissueOBO,,BTO:0000379,,,,,,,,,,,,,,,,,,,embryo,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5614,"[""eye disease""]",,An eye and adnexa disease that is located_in the eye.,false,,,http://purl.obolibrary.org/obo/DOID_1492,,,,,,,,An eye and adnexa disease that is located_in the eye.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5614,,,DOID:2933,ICD9CM:379.90|SNOMEDCT_US_2016_03_01:264555006|SNOMEDCT_US_2016_03_01:371405004|SNOMEDCT_US_2016_03_01:366261005|ICD9CM:360.9|SNOMEDCT_US_2016_03_01:193266000|SNOMEDCT_US_2016_03_01:155198005|SNOMEDCT_US_2016_03_01:155101007|ICD10CM:H44.9|SNOMEDCT_US_2016_03_01:193316008|SNOMEDCT_US_2016_03_01:79517001|ICD9CM:360|ICD10CM:H44|SNOMEDCT_US_2016_03_01:193265001|MESH:D005128|NCI:C26767|SNOMEDCT_US_2016_03_01:371409005|UMLS_CUI:C0015397|SNOMEDCT_US_2016_03_01:194183009|SNOMEDCT_US_2016_03_01:111509007,,,disease_ontology,,DOID:5614,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,eye disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300293,"[""JNK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300191,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300293,,,,,,,,,,,,,,,,,,,,,,,,,,,,JNK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400320,"[""HH498 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400165,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400320,,,,,,,,,,,,,,,,,,,,,,,,,,,,HH498 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100216,"[""Calcium/calmodulin-dependent protein kinase type 1d""]",,"A calcium/calmodulin-dependent protein kinase type 1D that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IU85] |calcium/calmodulin-dependent protein kinase type 1d (CAMK1D)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300171,,,,,,,,"A calcium/calmodulin-dependent protein kinase type 1D that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IU85] |calcium/calmodulin-dependent protein kinase type 1d (CAMK1D)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100216,,,,https://pharos.nih.gov/idg/targets/Q8IU85,,,,,,,,,,,,,CAMK1D,CAMKID,,Q8IU85,,,,,,,,Calcium/calmodulin-dependent protein kinase type 1d,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200203,"[""GPR61 gene""]",,"A G-protein coupled receptor 61 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BZJ8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 61 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BZJ8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200203,,,,,,,,,,,,,,,,83873,GPR61,BALGR,,,,,,,,,,GPR61 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000401,"[""THR790 in EGFR(L858R)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000401,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR790 in EGFR(L858R),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001356,"[""tendon""]",,A tough cord or band of dense white fibrous connective tissue that unites a muscle with some other part (as a bone) and transmits the force which the muscle exerts.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000421,,,,,,,,A tough cord or band of dense white fibrous connective tissue that unites a muscle with some other part (as a bone) and transmits the force which the muscle exerts.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001356,,,,,,,BrendaTissueOBO,,BTO:0001356,,,,,,,,,,,,,,,,,,,tendon,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000284,"[""MLK3 kinase domain""]",,Mitogen-activated protein kinase kinase kinase 11; MAP3K11; MEKK11; MGC17114; MLK3; MLK-3; PTK1; SPRK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase kinase kinase 11; MAP3K11; MEKK11; MGC17114; MLK3; MLK-3; PTK1; SPRK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000284,,,,,,,,,,,,,,,,,,,200269,,,,,,,,,MLK3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400277,"[""PKC delta subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400175,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400277,,,,,,,,,,,,,,,,,,,,,,,,,,,,PKC delta subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4535,"[""hypotrichosis""]",,"A hair disease that is characterized by sparse hair on the scalp resulting from abnormal hair follicle development and has_material_basis in mutations in proteins involved in hair growth, division or proliferation of cells within hair follicles.",false,,,http://purl.obolibrary.org/obo/DOID_421,,,,,,,,"A hair disease that is characterized by sparse hair on the scalp resulting from abnormal hair follicle development and has_material_basis in mutations in proteins involved in hair growth, division or proliferation of cells within hair follicles.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4535,,,,UMLS_CUI:C0020678|NCI:C34720|SNOMEDCT_US_2016_03_01:56558005|SNOMEDCT_US_2016_03_01:53602002|MESH:D007039|ORDO:55654|OMIM:PS605389,,,disease_ontology,,DOID:4535,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,hypotrichosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200119,"[""EIF2AK2 gene""]",,"The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400151,,,,,,,,"The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200119,,,,,,,,,,,,,,,,5610,EIF2AK2,PKR|PRKR,,,,,,,,,,EIF2AK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200501,"[""OR1M1 gene""]",,"An olfactory receptor 1M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200501,,,,,,,,,,,,,,,,125963,OR1M1,,,,,,,,,,,OR1M1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400038,"[""Endothelin receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400038,,,,,,,,,,,,,,,,,,,,,,,,,,,,Endothelin receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391024,"[""Uridine kinase family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300322,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391024,,,,,,,,,,,,,,,,,,,,,,,,,,,,Uridine kinase family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400213,"[""BUD32 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400213,,,,,,,,,,,,,,,,,,,,,,,,,,,,BUD32 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000040,"[""ALK(L1196M) kinase domain""]",,Anaplastic lymphoma receptor tyrosine kinase; ALK; CD246; NBLST3; TFG/ALK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Anaplastic lymphoma receptor tyrosine kinase; ALK; CD246; NBLST3; TFG/ALK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000040,,,,,,,,,,,,,,,,,,,200480,,,,,,,,,ALK(L1196M) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000151,"[""ERK5 kinase domain""]",,Mitogen-activated protein kinase 7; BMK1; ERK4; ERK5; MAPK7; PRKM7,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase 7; BMK1; ERK4; ERK5; MAPK7; PRKM7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000151,,,,,,,,,,,,,,,,,,,200155,,,,,,,,,ERK5 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000047,"[""LEU128 in NEK9""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000047,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU128 in NEK9,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200124,"[""EGFR gene""]",,"The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400152,,,,,,,,"The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200124,,,,,,,,,,,,,,,,1956,EGFR,ERBB|ERBB1|HER1,,,,,,,,,,EGFR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200137,"[""GRID1 gene""]",,"This gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.[provided by RefSeq, Jan 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400414,,,,,,,,"This gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.[provided by RefSeq, Jan 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200137,,,,,,,,,,,,,,,,2894,GRID1,KIAA1220,,,,,,,,,,GRID1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001455,"[""thymic carcinoma cell""]",,"Thymic carcinoma is a disease in which cancer (malignant) cells are found in the tissues of the thymus. Thymic carcinoma is difficult to treat and generally spreads to other parts of the body. People with thymoma often have other diseases of the immune system, most commonly myasthenia gravis, a disease in which the muscles become weak.",false,,,http://purl.obolibrary.org/obo/BTO_0001460|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Thymic carcinoma is a disease in which cancer (malignant) cells are found in the tissues of the thymus. Thymic carcinoma is difficult to treat and generally spreads to other parts of the body. People with thymoma often have other diseases of the immune system, most commonly myasthenia gravis, a disease in which the muscles become weak.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001455,,,,,,,BrendaTissueOBO,,BTO:0001455,,,,,,,,,,,,,,,,,,,thymic carcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100796,"[""Taste receptor type 2 member 5""]",,"A taste receptor type 2 member 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300014,,,,,,,,"A taste receptor type 2 member 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100796,,,,https://pharos.nih.gov/idg/targets/Q9NYW4,,,,,,,,,,,,,TAS2R5,,,Q9NYW4,,,,,,,,Taste receptor type 2 member 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4829,"[""adenosquamous cell lung carcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3908,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4829,,,,UMLS_CUI:C0279557|NCI:C9133,Adenosquamous lung carcinoma,,disease_ontology,,DOID:4829,,,,,,,,,,,,,,,,,,,adenosquamous cell lung carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_15646,"[""20-hydroxy-leukotriene B4""]","20-OH-Leukotriene B4|352.225|20-hydroxy-LTB4|(6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyicosa-6,8,10,14-tetraenoate|PTJFJXLGRSTECQ-PSPARDEHSA-N|OCCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O|20-OH-LTB4|352.46508|C20H32O5|(6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyeicosa-6,8,10,14-tetraenoate|InChI=1S/C20H32O5/c21-17-10-6-2-1-3-7-12-18(22)13-8-4-5-9-14-19(23)15-11-16-20(24)25/h3-5,7-9,13-14,18-19,21-23H,1-2,6,10-12,15-17H2,(H,24,25)/b5-4+,7-3-,13-8+,14-9-/t18-,19-/m1/s1|0",The 20-hydroxy derivative of leukotriene B4.,false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,PMID:8382231|HMDB:HMDB01509|LIPID_MAPS_instance:LMFA03020018|KEGG:C04853|PMID:8609415|PMID:3000366,The 20-hydroxy derivative of leukotriene B4.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:1293|CHEBI:19796|CHEBI:10932,,"20-Hydroxy-leukotriene B4|(5S,6Z,8E,10E,12R,14Z)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoic acid",,chebi_ontology,"20-OH-Leukotriene B4|352.225|20-hydroxy-LTB4|(6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyicosa-6,8,10,14-tetraenoate|PTJFJXLGRSTECQ-PSPARDEHSA-N|OCCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O|20-OH-LTB4|352.46508|C20H32O5|(6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyeicosa-6,8,10,14-tetraenoate|InChI=1S/C20H32O5/c21-17-10-6-2-1-3-7-12-18(22)13-8-4-5-9-14-19(23)15-11-16-20(24)25/h3-5,7-9,13-14,18-19,21-23H,1-2,6,10-12,15-17H2,(H,24,25)/b5-4+,7-3-,13-8+,14-9-/t18-,19-/m1/s1|0",,,CHEBI:15646,,,,,,,,,,,,,,,,,,,,,,,CHEBI:15646,,,,,20-hydroxy-leukotriene B4,,CHEBI:15646,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10652,"[""Alzheimer's disease""]",,"A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.",false,,,http://purl.obolibrary.org/obo/DOID_680,,,,,,,,"A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10652,,,,EFO:0000249|OMIM:502500|SNOMEDCT_US_2016_03_01:73768007|SNOMEDCT_US_2016_03_01:267688001|OMIM:604154|NCI:C2866|SNOMEDCT_US_2016_03_01:26929004|ICD9CM:331.0|MESH:D000544|UMLS_CUI:C0002395|SNOMEDCT_US_2016_03_01:154998003|KEGG:05010|OMIM:104300|ICD10CM:G30|ICD10CM:G30.9,AD|Alzheimers dementia|Alzheimer disease,,disease_ontology,"Alzheimer disease, familial",DOID:10652,,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,Alzheimer's disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1996,"[""rectum adenocarcinoma""]",,A rectum cancer that derives_from epithelial cells of glandular origin.,false,,,http://purl.obolibrary.org/obo/DOID_1993|http://purl.obolibrary.org/obo/DOID_0050913,,,,,,,,A rectum cancer that derives_from epithelial cells of glandular origin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1996,,,,UMLS_CUI:C0149978|SNOMEDCT_US_2016_03_01:254582000|NCI:C9383,Rectal adenocarcinoma|adenocarcinoma of rectum (disorder),,disease_ontology,adenocarcinoma of rectum,DOID:1996,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,rectum adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9191,"[""diabetic macular edema""]",,,false,,,http://purl.obolibrary.org/obo/DOID_8947,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9191,,,,ICD9CM:362.07|SNOMEDCT_US_2016_03_01:312912001|UMLS_CUI:C0730285,,,disease_ontology,,DOID:9191,,,,,,,,,,,,,,,,,,,diabetic macular edema,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100571,"[""Olfactory receptor 4c6""]",,"An olfactory receptor 4C6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH72] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4C6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH72] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100571,,,,https://pharos.nih.gov/idg/targets/Q8NH72,,,,,,,,,,,,,OR4C6,,,Q8NH72,,,,,,,,Olfactory receptor 4c6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200329,"[""MKNK2 gene""]",,"This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400296,,,,,,,,"This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200329,,,,,,,,,,,,,,,,2872,MKNK2,GPRK7|MNK2,,,,,,,,,,MKNK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000594,"[""liver cancer cell""]",,Malignant (cancer) cells are found in the tissues of the liver.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Malignant (cancer) cells are found in the tissues of the liver.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000594,,,,,,,BrendaTissueOBO,,BTO:0000594,,,,,,,,,,,,,,,,,,,liver cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100018,"[""Atypical chemokine receptor 2""]",,"A chemokine-binding protein 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00590] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300031,,,,,,,,"A chemokine-binding protein 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00590] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100018,,,,https://pharos.nih.gov/idg/targets/O00590,,,,,,,,,,,,,ACKR2,CCBP2|CCR10|CMKBR9|D6,,O00590,,,,,,,,Atypical chemokine receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100540,"[""Olfactory receptor 2m3""]",,"An olfactory receptor 2M3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG83] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2M3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG83] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100540,,,,https://pharos.nih.gov/idg/targets/Q8NG83,,,,,,,,,,,,,OR2M3,OR2M3P|OR2M6,,Q8NG83,,,,,,,,Olfactory receptor 2m3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100455,"[""Olfactory receptor 5h14""]",,"An olfactory receptor 5H14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NHG9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5H14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NHG9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100455,,,,https://pharos.nih.gov/idg/targets/A6NHG9,,,,,,,,,,,,,OR5H14,,,A6NHG9,,,,,,,,Olfactory receptor 5h14,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000301,"[""MUSK kinase domain""]",,"Muscle, skeletal, receptor tyrosine kinase; MGC126323; MGC126324; MUSK",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Muscle, skeletal, receptor tyrosine kinase; MGC126323; MGC126324; MUSK",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000301,,,,,,,,,,,,,,,,,,,200278,,,,,,,,,MUSK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003453,"[""dentin""]",,"The calcified tissue below the enamel, enclosing the cavity of the tooth containing the pulp chamber and root canals.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The calcified tissue below the enamel, enclosing the cavity of the tooth containing the pulp chamber and root canals.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003453,,,,,,,BrendaTissueOBO,,BTO:0003453,,,,,,,,,,,,,,,,,,,dentin,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4001,"[""ovarian carcinoma""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_2151,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4001,,,,UMLS_CUI:C0677886|MESH:C538090|EFO:0001075|NCI:C4908,Ovarian carcinoma,,disease_ontology,,DOID:4001,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,ovarian carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200598,"[""OR4L1 gene""]",,"An olfactory receptor 4L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH43] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH43] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200598,,,,,,,,,,,,,,,,122742,OR4L1,OR4L2P,,,,,,,,,,OR4L1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001018,"[""basophilic leukemia cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000737,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001018,,,,,,,BrendaTissueOBO,,BTO:0001018,,,,,,,,,,,,,,,,,,,basophilic leukemia cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100533,"[""Lymphokine-activated killer t-cell-originated protein kinase""]",,"A lymphokine-activated killer T-cell-originated protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96KB5] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300236,,,,,,,,"A lymphokine-activated killer T-cell-originated protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96KB5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100533,,,,https://pharos.nih.gov/idg/targets/Q96KB5,,,,,,,,,,,,,PBK,TOPK,,Q96KB5,,,,,,,,Lymphokine-activated killer t-cell-originated protein kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11060,"[""placenta praevia""]",,A placenta disease that is characterized by placenta attachment to the uterine wall close to or covering the cervix.,false,,,http://purl.obolibrary.org/obo/DOID_780,,,,,,,,A placenta disease that is characterized by placenta attachment to the uterine wall close to or covering the cervix.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11060,,,,SNOMEDCT_US_2016_03_01:36813001|NCI:C26858|SNOMEDCT_US_2016_03_01:157059004|MESH:D010923|UMLS_CUI:C0032046|ICD10CM:O44|SNOMEDCT_US_2016_03_01:198930005,,,disease_ontology,,DOID:11060,,,,,,,,,,,,,,,,,,,placenta praevia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000254,"[""MAP3K3 kinase domain""]",,Mitogen-activated protein kinase kinase kinase 3; MAP3K3; MAPKKK3; MEKK3; MEKK3/MAP3K3,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase kinase kinase 3; MAP3K3; MAPKKK3; MEKK3; MEKK3/MAP3K3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000254,,,,,,,,,,,,,,,,,,,200238,,,,,,,,,MAP3K3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100558,"[""Putative olfactory receptor 2w6""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100558,,,,https://pharos.nih.gov/idg/targets/Q8NHA6,,,,,,,,,,,,,OR2W6P,OR2W7P,,Q8NHA6,,,,,,,,Putative olfactory receptor 2w6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00000001,"[""GPCR ligand""]",,A ligand that interacts or binds with a G-protein coupled receptor protein.,false,,,http://purl.obolibrary.org/obo/CHEBI_23367,,,,,,,,A ligand that interacts or binds with a G-protein coupled receptor protein.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00000001,,,,,,,,,,,,,,,,,,,,,,,,,,,,GPCR ligand,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12960,"[""acrocephalosyndactylia""]",,A synostosis that results_in craniosynostosis and syndactyly.,false,,,http://purl.obolibrary.org/obo/DOID_11971,,,,,,,,A synostosis that results_in craniosynostosis and syndactyly.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12960,,,DOID:0080004,OMIM:101200|UMLS_CUI:C1510455|ICD9CM:755.55|SNOMEDCT_US_2016_03_01:205257004|MESH:D000168|SNOMEDCT_US_2016_03_01:268262006|SNOMEDCT_US_2016_03_01:63661009|NCI:C34348,Apert syndrome,,disease_ontology,,DOID:12960,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,acrocephalosyndactylia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000200,"[""MET745 in LATS2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000200,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET745 in LATS2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400182,"[""LISK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400107,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400182,,,,,,,,,,,,,,,,,,,,,,,,,,,,LISK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000106,"[""DAPK2 kinase domain""]",,Death-associated protein kinase 2; DAPK2; DRP1; DRP-1; MGC119312,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Death-associated protein kinase 2; DAPK2; DRP1; DRP-1; MGC119312,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000106,,,,,,,,,,,,,,,,,,,200107,,,,,,,,,DAPK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200175,"[""KCNMA1 gene""]",,"MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400531,,,,,,,,"MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200175,,,,,,,,,,,,,,,,3778,KCNMA1,KCNMA|SLO,,,,,,,,,,KCNMA1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002573,"[""TERA-2 cell""]",,Human embryonal carcinoma (teratocarcinoma). NTERA-2 was cloned from cell line TERA-2 which was derived from a metastatic teratocarcinoma of a 22-year-old Caucasian male.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001437,,,,,,,,Human embryonal carcinoma (teratocarcinoma). NTERA-2 was cloned from cell line TERA-2 which was derived from a metastatic teratocarcinoma of a 22-year-old Caucasian male.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002573,,,,,,,BrendaTissueOBO,,BTO:0002573,,,,,,,,,,,,,,,,,,,TERA-2 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000170,"[""MET437 in M3K2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000170,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET437 in M3K2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100243,"[""Potassium voltage-gated channel subfamily v member 1""]",,A voltage-gated potassium channel KCNV1 that is encoded in the genome of human. [] ,false,,,http://www.drugtargetontology.org/dto/DTO_01300572,,,,,,,,A voltage-gated potassium channel KCNV1 that is encoded in the genome of human. [] ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100243,,,,https://pharos.nih.gov/idg/targets/Q6PIU1,,,,,,,,,,,,,KCNV1,,,Q6PIU1,,,,,,,,Potassium voltage-gated channel subfamily v member 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400571,"[""KCa5.1/KCNU1 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400437,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400571,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCa5.1/KCNU1 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100030,"[""Serine/threonine-protein kinase a-raf""]",,"A serine/threonine-protein kinase A-Raf that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10398] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300126,,,,,,,,"A serine/threonine-protein kinase A-Raf that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10398] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100030,,,,https://pharos.nih.gov/idg/targets/P10398,,,,,,,,,,,,,ARAF,ARAF1|PKS|PKS2,,P10398,,,,,,,,Serine/threonine-protein kinase a-raf,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5418,"[""schizoaffective disorder""]",,A psychotic disorder that is characterized by recurring episodes of mood fluctuations and a loss of contact with reality.,false,,,http://purl.obolibrary.org/obo/DOID_2468,,,,,,,,A psychotic disorder that is characterized by recurring episodes of mood fluctuations and a loss of contact with reality.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5418,,,,SNOMEDCT_US_2016_03_01:191567000|SNOMEDCT_US_2016_03_01:68890003|SNOMEDCT_US_2016_03_01:191568005|ICD10CM:F25.9|SNOMEDCT_US_2016_03_01:192345003|UMLS_CUI:C0036337|SNOMEDCT_US_2016_03_01:231490005|ICD9CM:295.7|ICD10CM:F25|SNOMEDCT_US_2016_03_01:191575006|MESH:D011618|NCI:C94378,,,disease_ontology,,DOID:5418,,,,,,,,,,,,,,,,,,,schizoaffective disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300161,"[""HASPIN family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300161,,,,,,,,,,,,,,,,,,,,,,,,,,,,HASPIN family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000405,"[""SgK110 kinase domain""]",,Putative uncharacterized serine/threonine-protein kinase (Sugen kinase 110); SgK110,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Putative uncharacterized serine/threonine-protein kinase (Sugen kinase 110); SgK110,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000405,,,,,,,,,,,,,,,,,,,200408,,,,,,,,,SgK110 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000075,"[""antennal gland""]",,Excretory gland situated in the basal article of the antennal peduncle.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000431,,,,,,,,Excretory gland situated in the basal article of the antennal peduncle.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000075,,,,,,,BrendaTissueOBO,,BTO:0000075,,,,,,,,,,,,,,,,,,,antennal gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100333,"[""Olfactory receptor 11h6""]",,"An olfactory receptor 11H6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 11H6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100333,,,,https://pharos.nih.gov/idg/targets/Q8NGC7,,,,,,,,,,,,,OR11H6,,,Q8NGC7,,,,,,,,Olfactory receptor 11h6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300147,"[""DCAMKL family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300147,,,,,,,,,,,,,,,,,,,,,,,,,,,,DCAMKL family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000256,"[""MAP4K2 kinase domain""]",,Mitogen-activated protein kinase kinase kinase kinase 2; BL44; GCK; MAP4K2; RAB8IP,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase kinase kinase kinase 2; BL44; GCK; MAP4K2; RAB8IP,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000256,,,,,,,,,,,,,,,,,,,200240,,,,,,,,,MAP4K2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100682,"[""Olfactory receptor 7G1""]",,"An olfactory receptor 7G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 7G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100682,,,,https://pharos.nih.gov/idg/targets/Q8NGA0,,,,,,,,,,,,,OR7G1,OR7G1P,,Q8NGA0,,,,,,,,Olfactory receptor 7G1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200092,"[""KCNIP3 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200092,,,,,,,,,,,,,,,,,KCNIP3,,,,,,,,,,,KCNIP3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100595,"[""Pantothenate kinase 4""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100595,,,,,,,,,,,,,,,,,PANK4,,,Q9NVE7,,,,,,,,Pantothenate kinase 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000455,"[""VGFR1 kinase domain""]",,Vascular endothelial growth factor receptor 1; fms-related tyrosine kinase 1; vascular permeability factor receptor; FLT; FLT1; VEGFR1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Vascular endothelial growth factor receptor 1; fms-related tyrosine kinase 1; vascular permeability factor receptor; FLT; FLT1; VEGFR1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000455,,,,,,,,,,,,,,,,,,,200167,,,,,,,,,VGFR1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003307,"[""L6E9 cell""]",,Rat myoblast cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0000256|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Rat myoblast cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003307,,,,,,,BrendaTissueOBO,,BTO:0003307,,,,,,,,,,,,,,,,,,,L6E9 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100614,"[""Nucleoside diphosphate kinase, mitochondrial""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100614,,,,,,,,,,,,,,,,,NME4,,,O00746,,,,,,,,"Nucleoside diphosphate kinase, mitochondrial",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_15760,"[""tyramine""]","4-hydroxyphenethylamine|NCCc1ccc(O)cc1|137.17900|4-Hydroxyphenylethylamine|p-(2-Aminoethyl)phenol|p-hydroxyphenylethylamine|DZGWFCGJZKJUFP-UHFFFAOYSA-N|p-(2-aminoethyl)phenol|2-(p-Hydroxyphenyl)ethylamine|137.084|p-hydroxyphenethylamine|Tyramin|4-Hydroxy-beta-phenylethylamine|beta-(4-Hydroxyphenyl)ethylamine|0|InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2|C8H11NO|p-tyramine",A primary amino compound obtained by formal decarboxylation of the amino acid tyrosine.,false,,,http://purl.obolibrary.org/obo/CHEBI_32952,,,,,,,MetaCyc:TYRAMINE|PMID:15000446|LINCS:LSM-19016|Beilstein:1099914|PMID:3137238|PMID:19137318|PMID:12183041|PMID:21628600|PMID:12811595|Gmelin:82946|KNApSAcK:C00001435|PMID:18422653|Wikipedia:Tyramine|CAS:51-67-2|PDBeChem:AEF|PMID:21570963|KEGG:C00483|PMID:21651557|PMID:15848803|PMID:11919655|PMID:22735334|Drug_Central:2784|PMID:21909937|PMID:19189084|PMID:18970430|Reaxys:1099914|PMID:21850574|HMDB:HMDB00306|PMID:21679153,A primary amino compound obtained by formal decarboxylation of the amino acid tyrosine.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:27174|CHEBI:9799|CHEBI:15276,,Tyramine|4-(2-aminoethyl)phenol,,chebi_ontology,"4-hydroxyphenethylamine|NCCc1ccc(O)cc1|137.17900|4-Hydroxyphenylethylamine|p-(2-Aminoethyl)phenol|p-hydroxyphenylethylamine|DZGWFCGJZKJUFP-UHFFFAOYSA-N|p-(2-aminoethyl)phenol|2-(p-Hydroxyphenyl)ethylamine|137.084|p-hydroxyphenethylamine|Tyramin|4-Hydroxy-beta-phenylethylamine|beta-(4-Hydroxyphenyl)ethylamine|0|InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2|C8H11NO|p-tyramine",,,CHEBI:15760,,,,,,,,,,,,,,,,,,,,,,,CHEBI:15760,,,,,tyramine,,CHEBI:15760,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400354,"[""Ryanodine-inositol 1,4,5-triphosphate receptor calcium channel (rir-cac) family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400354,,,,,,,,,,,,,,,,,,,,,,,,,,,,"Ryanodine-inositol 1,4,5-triphosphate receptor calcium channel (rir-cac) family gene",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200272,"[""LRRK1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400184,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200272,,,,,,,,,,,,,,,,79705,LRRK1,KIAA1790,,,,,,,,,,LRRK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200655,"[""OR6C2 gene""]",,"An olfactory receptor 6C2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZP2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6C2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZP2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200655,,,,,,,,,,,,,,,,341416,OR6C2,,,,,,,,,,,OR6C2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400539,"[""Kv2.1/KCNB1 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400442,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400539,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv2.1/KCNB1 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002096,"[""nasal cavity""]",,"The portion of the passages of the respiratory system extending from the nares to the pharynx. It is divided into left and right halves by the nasal septum; its floor is the hard palate, which separates it from the oral cavity; and its lateral walls contain the nasal conchae and nasal meatus.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The portion of the passages of the respiratory system extending from the nares to the pharynx. It is divided into left and right halves by the nasal septum; its floor is the hard palate, which separates it from the oral cavity; and its lateral walls contain the nasal conchae and nasal meatus.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002096,,,,,,,BrendaTissueOBO,cavitas nasi|cavitas nasalis,BTO:0002096,,,,,,,,,,,,,,,,,,,nasal cavity,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9650,"[""pathologic nystagmus""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1279,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9650,,,,UMLS_CUI:C0028738|SNOMEDCT_US_2016_03_01:194172000|ICD9CM:379.50|ICD10CM:H55.00|SNOMEDCT_US_2016_03_01:563001|ICD10CM:H55.0|NCI:C3282|SNOMEDCT_US_2016_03_01:267750005|SNOMEDCT_US_2016_03_01:155205009|MESH:D009759|SNOMEDCT_US_2016_03_01:194171007,,,disease_ontology,,DOID:9650,,,,,,,,,,,,,,,,,,,pathologic nystagmus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003358,"[""groin""]",,"In anatomy, the area where the upper thigh meets the trunk. More precisely, the fold or depression marking the juncture of the lower abdomen and the inner part of the thigh.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"In anatomy, the area where the upper thigh meets the trunk. More precisely, the fold or depression marking the juncture of the lower abdomen and the inner part of the thigh.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003358,,,,,,,BrendaTissueOBO,inguinal region|inguen|iliac region,BTO:0003358,,,,,,,,,,,,,,,,,,,groin,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100737,"[""Proteinase-activated receptor 1""]",,"A proteinase-activated receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25116] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300079,,,,,,,,"A proteinase-activated receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25116] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100737,,,,https://pharos.nih.gov/idg/targets/P25116,,,,,,,,,,,,,F2R,CF2R|PAR1|TR,,P25116,,,,,,,,Proteinase-activated receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400516,"[""GABRE sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400516,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRE sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100236,"[""Potassium voltage-gated channel subfamily kqt member 5""]",,"A voltage-gated potassium channel subunit KCNQ5 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9NR82] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300565,,,,,,,,"A voltage-gated potassium channel subunit KCNQ5 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9NR82] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100236,,,,https://pharos.nih.gov/idg/targets/Q9NR82,,,,,,,,,,,,,KCNQ5,,,Q9NR82,,,,,,,,Potassium voltage-gated channel subfamily kqt member 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002426,"[""CHOP cell""]",,Chinese hamster ovary cells expressing polyoma LT antigen.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Chinese hamster ovary cells expressing polyoma LT antigen.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002426,,,,,,,BrendaTissueOBO,,BTO:0002426,,,,,,,,,,,,,,,,,,,CHOP cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000211,"[""caudate nucleus""]",,One of the centrally-located portions of the brain affected by Huntington's Disease. Speech and swallowing problems arise when this region and another region called the putamen are affected.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,One of the centrally-located portions of the brain affected by Huntington's Disease. Speech and swallowing problems arise when this region and another region called the putamen are affected.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000211,,,,,,,BrendaTissueOBO,nucleus caudatus|caudatum,BTO:0000211,,,,,,,,,,,,,,,,,,,caudate nucleus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3405,"[""histiocytosis""]",,A lymphatic system disease that is characterized by an excessive number of histiocytes.,false,,,http://purl.obolibrary.org/obo/DOID_75,,,,,,,,A lymphatic system disease that is characterized by an excessive number of histiocytes.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3405,,,DOID:3344,NCI:C3106|SNOMEDCT_US_2016_03_01:65396000|SNOMEDCT_US_2016_03_01:190957008|SNOMEDCT_US_2016_03_01:60657004|UMLS_CUI:C0019618|MESH:D015614,chronic Histiocytosis X|Hand Schuller Christian disease,,disease_ontology,,DOID:3405,,,,,,,,,,,,,,,,,,,histiocytosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100339,"[""Protein tweety homolog 1""]",,"A protein tweety homolog 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H313] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300373,,,,,,,,"A protein tweety homolog 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H313] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100339,,,,https://pharos.nih.gov/idg/targets/Q9H313,,,,,,,,,,,,,TTYH1,,,Q9H313,,,,,,,,Protein tweety homolog 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005264,"[""mucoepidermoid carcinoma cell""]",,Mucoepidermoid carcinoma (MEC) is the most common primary salivary gland-type tumour of the lung. It arises from the excretory ducts of the bronchial mucosa.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000551,,,,,,,,Mucoepidermoid carcinoma (MEC) is the most common primary salivary gland-type tumour of the lung. It arises from the excretory ducts of the bronchial mucosa.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005264,XPMUser,2011-10-05T08:46:31Z,,,,,BrendaTissueOBO,,BTO:0005264,,,,,,,,,,,,,,,,,,,mucoepidermoid carcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10690,"[""mastitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3463,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10690,,,,UMLS_CUI:C0024894|SNOMEDCT_US_2016_03_01:266641007|SNOMEDCT_US_2016_03_01:198099006|SNOMEDCT_US_2016_03_01:266644004|SNOMEDCT_US_2016_03_01:155955007|SNOMEDCT_US_2016_03_01:155952005|NCI:C53662|SNOMEDCT_US_2016_03_01:45198002|MESH:D008413,breast inflammation|Inflammatory breast disease|Inflammatory disease of breast,,disease_ontology,,DOID:10690,,,,,,,,,,,,,,,,,,,mastitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200040,"[""BCKDK gene""]",,"The branched-chain alpha-ketoacid dehydrogenase complex (BCKD) is an important regulator of the valine, leucine, and isoleucine catabolic pathways. The protein encoded by this gene is found in the mitochondrion, where it phosphorylates and inactivates BCKD. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400131,,,,,,,,"The branched-chain alpha-ketoacid dehydrogenase complex (BCKD) is an important regulator of the valine, leucine, and isoleucine catabolic pathways. The protein encoded by this gene is found in the mitochondrion, where it phosphorylates and inactivates BCKD. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200040,,,,,,,,,,,,,,,,10295,BCKDK,,,,,,,,,,,BCKDK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400204,"[""NKF3 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400204,,,,,,,,,,,,,,,,,,,,,,,,,,,,NKF3 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004574,"[""dermal microvascular endothelial cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003123,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004574,mgr,2010-04-11T11:11:39Z,,,,,BrendaTissueOBO,DMEC cell,BTO:0004574,,,,,,,,,,,,,,,,,,,dermal microvascular endothelial cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_05390002,"[""Putative mental health drug target""]",,,false,,,http://purl.obolibrary.org/obo/PR_000000001,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_05390002,,,,,,,,,,,,,,,,,,,,,,,,,,,,Putative mental health drug target,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200033,"[""ADRB1 gene""]",,"A beta-1 adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08588] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400094,,,,,,,,"A beta-1 adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08588] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200033,,,,,,,,,,,,,,,,153,ADRB1,ADRB1R|B1AR,,,,,,,,,,ADRB1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217553,"[""RXRG gene""]",,"This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_00217468,,,,,,,,"This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217553,,,,,,,,,,,,,,,,6258,RXRG,NR2B3,,,,,,,,,,RXRG gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003070,"[""S2 cell""]",,The hybridoma line S2 has been obtained by fusion of the myeloma P3x63 Ag6.653 and spleen cells from (C57 BL/6 x BALB/c) F1 female mice after a single injection of lymphoblastoid cells.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001926,,,,,,,,The hybridoma line S2 has been obtained by fusion of the myeloma P3x63 Ag6.653 and spleen cells from (C57 BL/6 x BALB/c) F1 female mice after a single injection of lymphoblastoid cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003070,,,,,,,BrendaTissueOBO,,BTO:0003070,,,,,,,,,,,,,,,,,,,S2 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000964,"[""oocyte""]",,"The immature reproductive cell prior to fertilization; it is derived from an oogonium, and is called a primary oocyte prior to completion of the first maturation division, and a secondary oocyte between the first and second maturation division.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000535,,,,,,,,"The immature reproductive cell prior to fertilization; it is derived from an oogonium, and is called a primary oocyte prior to completion of the first maturation division, and a secondary oocyte between the first and second maturation division.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000964,,,,,,,BrendaTissueOBO,,BTO:0000964,,,,,,,,,,,,,,,,,,,oocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001799,"[""pulmonary vein""]",,A vein that carries oxygenated blood from the lungs to the left atrium of the heart.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000234,,,,,,,,A vein that carries oxygenated blood from the lungs to the left atrium of the heart.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001799,,,,,,,BrendaTissueOBO,,BTO:0001799,,,,,,,,,,,,,,,,,,,pulmonary vein,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300353,"[""Inward rectifier-type potassium channel family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300353,,,,,,,,,,,,,,,,,,,,,,,,,,,,Inward rectifier-type potassium channel family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200040,"[""ADGRB2 gene""]",,"A brain-specific angiogenesis inhibitor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60241] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,"A brain-specific angiogenesis inhibitor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60241] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200040,,,,,,,,,,,,,,,,576,BAI2,,,,,,,,,,,ADGRB2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_16796,"[""Melatonin""]","Melovine|N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]-Acetamide|Melatol|N-Acetyl-5-methoxy-tryptamine|Melatonin (synth.) ultra-pure|N-(2-(5-Methoxyindol-3-yl)ethyl)acetamide|N-[2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide|Circadin|COc1ccc2[nH]cc(CCNC(C)=O)c2c1|N-(2-(5-Methoxyindol-3-yl)ethyl)-Acetamide|Regulin|5-methoxy-N-acetyltryptamine|N-[2-(5-methoxyindol-3-yl)ethyl]acetamide|C13H16N2O2|
InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
|N-[2-(5-Methoxyindol-3-yl)ethyl]-Acetamide|Melatonin (synth.) standard-grade|N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide|{N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-} Acetamide|N-Acetyl-5-methoxy-tryptamine Melatonine|N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide|MT6|melatonine|{N-[2-(5-methoxyindol-3-yl)ethyl]-} Acetamide|N-Acetyl-5-methoxytryptamine|DRLFMBDRBRZALE-UHFFFAOYSA-N","
A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.
",false,,,http://purl.obolibrary.org/obo/CHEBI_32952,,,,,,,CiteXplore:11721091|CiteXplore:16217125|CiteXplore:18485664|CiteXplore:11510949|KEGG DRUG:D08170|CiteXplore:288858|DrugBank:DB01065|CiteXplore:12767050|HMDB:HMDB01389|CiteXplore:15681810|CiteXplore:16030176|CiteXplore:12853293|CiteXplore:11462772|CiteXplore:16217126|CiteXplore:16150115|ChemIDplus:73-31-4|KEGG COMPOUND:73-31-4|CiteXplore:9449169|CiteXplore:15683468|CiteXplore:10960829|CiteXplore:12395907|CiteXplore:16258371|CiteXplore:7773197|Beilstein:205542|CiteXplore:14767300|Reaxys:205542|CiteXplore:18212404|CiteXplore:15206778|CiteXplore:18187545|NIST Chemistry WebBook:73-31-4|CiteXplore:12142740|CiteXplore:16441547|CiteXplore:16678784|CiteXplore:16207290|MetaCyc:N-ACETYL-5-METHOXY-TRYPTAMINE|PDBeChem:ML1|KEGG COMPOUND:C01598|CiteXplore:16573644|CiteXplore:16441550|CiteXplore:11339508|Wikipedia:Melatonin|CiteXplore:15992934,"
A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:14577|CHEBI:6730|CHEBI:25180,,Melatonin|N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide|melatonin,,chebi_ontology,"Melovine|N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]-Acetamide|Melatol|N-Acetyl-5-methoxy-tryptamine|Melatonin (synth.) ultra-pure|N-(2-(5-Methoxyindol-3-yl)ethyl)acetamide|N-[2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide|Circadin|COc1ccc2[nH]cc(CCNC(C)=O)c2c1|N-(2-(5-Methoxyindol-3-yl)ethyl)-Acetamide|Regulin|5-methoxy-N-acetyltryptamine|N-[2-(5-methoxyindol-3-yl)ethyl]acetamide|C13H16N2O2|
InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
|N-[2-(5-Methoxyindol-3-yl)ethyl]-Acetamide|Melatonin (synth.) standard-grade|N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide|{N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-} Acetamide|N-Acetyl-5-methoxy-tryptamine Melatonine|N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide|MT6|melatonine|{N-[2-(5-methoxyindol-3-yl)ethyl]-} Acetamide|N-Acetyl-5-methoxytryptamine|DRLFMBDRBRZALE-UHFFFAOYSA-N",,,CHEBI:16796,,,,,,,,,,,,,,,,,,,,,,,CHEBI:16796,,,,,Melatonin|melatonin,,CHEBI:16796,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200793,"[""TAS2R1 gene""]",,"A taste receptor type 2 member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400014,,,,,,,,"A taste receptor type 2 member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200793,,,,,,,,,,,,,,,,50834,TAS2R1,,,,,,,,,,,TAS2R1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000150,"[""ERK4 kinase domain""]",,Mitogen-activated protein kinase 4; ERK3; Erk4; MAPK4; p63MAPK; PRKM4,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase 4; ERK3; Erk4; MAPK4; p63MAPK; PRKM4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000150,,,,,,,,,,,,,,,,,,,200154,,,,,,,,,ERK4 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400339,"[""Epithelial chloride channel (e-clc) family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400339,,,,,,,,,,,,,,,,,,,,,,,,,,,,Epithelial chloride channel (e-clc) family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100698,"[""Olfactory receptor 8h2""]",,"An olfactory receptor 8H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N162] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 8H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N162] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100698,,,,https://pharos.nih.gov/idg/targets/Q8N162,,,,,,,,,,,,,OR8H2,,,Q8N162,,,,,,,,Olfactory receptor 8h2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000332,"[""THR315 in ABL1(H396P)-phosphorylated""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000332,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR315 in ABL1(H396P)-phosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050847,"[""sleep apnea""]",,A sleep disorder characterized by repeated cessation and commencing of breathing that repeatedly disrupts sleep.,false,,,http://purl.obolibrary.org/obo/DOID_535,,,,,,,,A sleep disorder characterized by repeated cessation and commencing of breathing that repeatedly disrupts sleep.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050847,lschriml,2014-03-20T03:57:22Z,,,,,disease_ontology,,DOID:0050847,,,,,,,,,,,,,,,,,,,sleep apnea,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050840,"[""cervical dystonia""]",,"A focal dystonia that is characterized by simultaneous contraction of the agonist and antagonist muscles that control the position of the head contracting during dystonic movement which causes the neck to involuntarily turn to the left, right, upwards, and/or downwards.",false,,,http://purl.obolibrary.org/obo/DOID_0050836,,,,,,,,"A focal dystonia that is characterized by simultaneous contraction of the agonist and antagonist muscles that control the position of the head contracting during dystonic movement which causes the neck to involuntarily turn to the left, right, upwards, and/or downwards.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050840,lschriml,2014-03-18T01:30:33Z,,,spasmodic torticollis,,disease_ontology,,DOID:0050840,,,,,,,,,,,,,,,,,,,cervical dystonia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050848,"[""obstructive sleep apnea""]",,"A sleep apnea that is characterized by repeated collapse and obstruction of the upper airway during sleep, which results in reduced airflow (hypopnea) or complete airflow cessation (apnea), oxygen desaturation, and arousals from sleep.",false,,,http://purl.obolibrary.org/obo/DOID_0050847,,,,,,,,"A sleep apnea that is characterized by repeated collapse and obstruction of the upper airway during sleep, which results in reduced airflow (hypopnea) or complete airflow cessation (apnea), oxygen desaturation, and arousals from sleep.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050848,lschriml,2014-03-20T03:57:22Z,,UMLS_CUI:C0037315|SNOMEDCT_US_2016_03_01:230493001|UMLS_CUI:C0338495|SNOMEDCT_US_2016_03_01:73430006|UMLS_CUI:C0020529|ICD9CM:780.57|ICD10CM:G47.3|MESH:D012891|NCI:C26884|SNOMEDCT_US_2016_03_01:194441007|OMIM:107650|SNOMEDCT_US_2016_03_01:313246000|ICD10CM:G47.30|SNOMEDCT_US_2016_03_01:206750008|SNOMEDCT_US_2016_03_01:155614007|SNOMEDCT_US_2016_03_01:196166002,obstructive sleep apnea syndrome,,disease_ontology,,DOID:0050848,,,,,,,,,,,,,,,,,Xref MGI.,,obstructive sleep apnea,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300359,"[""Two pore domain potassium channel family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300359,,,,,,,,,,,,,,,,,,,,,,,,,,,,Two pore domain potassium channel family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000199,"[""cardiac muscle""]",,The principal muscle tissue of the vertebrate heart made up of striated fibers that appear to be separated from each other under the electron microscope but that function in long-term rhythmic contraction as if in protoplasmic continuity.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0002385|http://purl.obolibrary.org/obo/BTO_0000887,,,,,,,,The principal muscle tissue of the vertebrate heart made up of striated fibers that appear to be separated from each other under the electron microscope but that function in long-term rhythmic contraction as if in protoplasmic continuity.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000199,,,,,,,BrendaTissueOBO,heart muscle|muscle of heart,BTO:0000199,,,,,,,,,,,,,,,,,,,cardiac muscle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100131,"[""Ephrin type-a receptor 7""]",,"ephrin type-a receptor 7 (EPHA7)  with  no mutation  in a nonphosphorylated state|An ephrin type-A receptor 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15375] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300153,,,,,,,,"ephrin type-a receptor 7 (EPHA7)  with  no mutation  in a nonphosphorylated state|An ephrin type-A receptor 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15375] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100131,,,,https://pharos.nih.gov/idg/targets/Q15375,,,,,,,,,,,,,EPHA7,EHK3|HEK11,,Q15375,,,,,,,,Ephrin type-a receptor 7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000033,"[""GnRH I""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000033,,,,,,,,,,,,,,,,,,,,,,,,,,,,GnRH I,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000006,"[""ASN376 in WEE1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_50347,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000006,,,,,,,,,,,,,,,,,,,,,,,,,,,,ASN376 in WEE1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001397,"[""trophozoite""]",,"A protozoan, especially of the class Sporozoa, in the active stage of its life cycle.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000749,,,,,,,,"A protozoan, especially of the class Sporozoa, in the active stage of its life cycle.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001397,,,,,,,BrendaTissueOBO,,BTO:0001397,,,,,,,,,,,,,,,,,,,trophozoite,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000022,"[""ABL1(T315I)-phosphorylated kinase domain""]",,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",false,,,http://www.drugtargetontology.org/dto/DTO_61000020,,,,,,,,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000022,,,,,,,,,,,,,,,,,,,200021,,,,,,,,,ABL1(T315I)-phosphorylated kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000314,"[""NEK4 kinase domain""]",,NIMA (never in mitosis gene a)-related kinase 4; MGC33171; NEK4; NRK2; pp12301; STK2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,NIMA (never in mitosis gene a)-related kinase 4; MGC33171; NEK4; NRK2; pp12301; STK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000314,,,,,,,,,,,,,,,,,,,200290,,,,,,,,,NEK4 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001910,"[""NCI-H441 cell""]",,Homo sapiens lung papillary adenocarcinoma cell line. The NCI-H441 cell line was derived in 1982 from the pericardial fluid of a patient with papillary adenocarcinoma of the lung.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001911,,,,,,,,Homo sapiens lung papillary adenocarcinoma cell line. The NCI-H441 cell line was derived in 1982 from the pericardial fluid of a patient with papillary adenocarcinoma of the lung.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001910,,,,,,,BrendaTissueOBO,H-441 cell,BTO:0001910,,,,,,,,,,,,,,,,,,,NCI-H441 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14042,"[""bipolar I disorder""]",,A bipolar disorder that is characterized by at least one manic or mixed episode.,false,,,http://purl.obolibrary.org/obo/DOID_3312,,,,,,,,A bipolar disorder that is characterized by at least one manic or mixed episode.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14042,,,,ICD9CM:296.50|SNOMEDCT_US_2016_03_01:49468007|UMLS_CUI:C0236773,,,disease_ontology,,DOID:14042,,,,,,,,,,,,,,,,,,,bipolar I disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14040,"[""autoimmune polyendocrine syndrome""]",,An autoimmune disease of endocrine system characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs.,false,,,http://purl.obolibrary.org/obo/DOID_0060005,,,,,,,,An autoimmune disease of endocrine system characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14040,,,,ICD10CM:E31.0|SNOMEDCT_US_2016_03_01:190567009|UMLS_CUI:C0085409|NCI:C84576|SNOMEDCT_US_2016_03_01:18947001|SNOMEDCT_US_2016_03_01:41864002|MESH:D016884|SNOMEDCT_US_2016_03_01:190568004,autoimmune polyendocrinopathy|Autoimmune polyglandular failure|Lloyd's syndrome,,disease_ontology,,DOID:14040,,,,,,,,,,,,,,,,,,,autoimmune polyendocrine syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200006,"[""CHRNA10 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400490,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200006,,,,,,,,,,,,,,,,57053,CHRNA10,NACHRA10,,,,,,,,,,CHRNA10 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100450,"[""Olfactory receptor 5AN1""]",,"An olfactory receptor 5AN1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5AN1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100450,,,,https://pharos.nih.gov/idg/targets/Q8NGI8,,,,,,,,,,,,,OR5AN1,,,Q8NGI8,,,,,,,,Olfactory receptor 5AN1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003917,"[""KB-V1 cell""]",,Human cervix carcinoma cell line resistant to vinblastine; a multidrug-resistant (mdr) subclone derived from KB-3-1.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human cervix carcinoma cell line resistant to vinblastine; a multidrug-resistant (mdr) subclone derived from KB-3-1.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003917,,,,,,,BrendaTissueOBO,,BTO:0003917,,,,,,,,,,,,,,,,,,,KB-V1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050811,"[""congenital adrenal hyperplasia""]",,A steroid inherited metabolic disorder that is characterized by adrenal insufficiency and variable degrees of hyper or hypo androgeny manifestations resulting from steroidogenic enzyme deficiency.,false,,,http://purl.obolibrary.org/obo/DOID_1701,,,,,,,,A steroid inherited metabolic disorder that is characterized by adrenal insufficiency and variable degrees of hyper or hypo androgeny manifestations resulting from steroidogenic enzyme deficiency.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050811,lschriml,2013-12-04T12:52:02Z,,OMIM:202010|SNOMEDCT_US_2016_03_01:154706003|OMIM:201910|ORDO:418|SNOMEDCT_US_2016_03_01:190510000|SNOMEDCT_US_2016_03_01:267395000|ICD10CM:E25.9|UMLS_CUI:C0701163|SNOMEDCT_US_2016_03_01:190519004|OMIM:201710|ICD10CM:E25|OMIM:201810|OMIM:202110|ICD9CM:255.2,adrenal hyperplasia 1|congenital lipoid adrenal hyperplasia |lipoid CAH,,disease_ontology,,DOID:0050811,,,,,,,,,,,,,,,,,Xref MGI.,,congenital adrenal hyperplasia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050816,"[""urofacial syndrome""]",,An autosomal recessive disease that is characterized by inverted facial expressions in association with a severe and early-onset form of dysfunctional urinary voiding.,false,,,http://purl.obolibrary.org/obo/DOID_0050737,,,,,,,,An autosomal recessive disease that is characterized by inverted facial expressions in association with a severe and early-onset form of dysfunctional urinary voiding.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050816,lschriml,2013-12-05T01:10:52Z,,OMIM:615112|OMIM:236730,Ochoa syndrome|hydronephrosis with peculiar facial expression,,disease_ontology,,DOID:0050816,,,,,,,,,,,,,,,,,,,urofacial syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050815,"[""eye adnexa disease""]",,An eye and adnexa disease that is located_in the adnexa of the eye.,false,,,http://purl.obolibrary.org/obo/DOID_1492,,,,,,,,An eye and adnexa disease that is located_in the adnexa of the eye.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050815,lschriml,2013-12-05T12:55:42Z,,,,,disease_ontology,,DOID:0050815,,,,,,,,,,,,,,,,,,,eye adnexa disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050709,"[""Ohtahara syndrome""]",,A neonatoal period electroclinical syndrome that is characterized by tonic spasms and partial seizures.,false,,,http://purl.obolibrary.org/obo/DOID_0050702,,,,,,,,A neonatoal period electroclinical syndrome that is characterized by tonic spasms and partial seizures.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050709,lschriml,2012-05-10T10:02:58Z,,OMIM:614959|OMIM:308350|OMIM:613477|OMIM:613721|OMIM:613402|OMIM:615473|OMIM:300088|OMIM:614558|OMIM:615338|OMIM:613720|OMIM:615006|OMIM:612164|OMIM:300672|OMIM:615476|OMIM:609304|OMIM:613722|OMIM:300607,"EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 15|Early Infantile Epileptic Encephalopathy with Burst-Suppression|Early Infantile Epileptic Encephalopathy ",,disease_ontology,,DOID:0050709,,,,,,,,,,,,,,,,,,,Ohtahara syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050701,"[""electroclinical syndrome""]",,"An epilepsy syndrome that is a group of clinical entities showing a cluster of electro-clinical characteristics, classified according to age at onset, cognitive and developmental antecedents and consequences, motor and sensory examinations, EEG features, provoking or triggering factors, and patterns of seizure occurrence with respect to sleep.",false,,,http://purl.obolibrary.org/obo/DOID_1826,,,,,,,,"An epilepsy syndrome that is a group of clinical entities showing a cluster of electro-clinical characteristics, classified according to age at onset, cognitive and developmental antecedents and consequences, motor and sensory examinations, EEG features, provoking or triggering factors, and patterns of seizure occurrence with respect to sleep.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050701,lschriml,2012-04-11T11:42:46Z,,,electro-clinical syndrome,,disease_ontology,,DOID:0050701,,,,,,,,,,,,,,,,,,,electroclinical syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050706,"[""variable age at onset electroclinical syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0050701,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050706,lschriml,2012-04-11T11:48:18Z,,,,,disease_ontology,,DOID:0050706,,,,,,,,,,,,,,,,,,,variable age at onset electroclinical syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050702,"[""neonatal period electroclinical syndrome""]",,An electroclinical syndrome with onset in the neonatal period less than 44 weeks of gestational age.,false,,,http://purl.obolibrary.org/obo/DOID_0050701,,,,,,,,An electroclinical syndrome with onset in the neonatal period less than 44 weeks of gestational age.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050702,lschriml,2012-04-11T11:48:18Z,,,,,disease_ontology,,DOID:0050702,,,,,,,,,,,,,,,,,,,neonatal period electroclinical syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050703,"[""infancy electroclinical syndrome""]",,An electroclinical syndrome with onset in infancy occurring between birth and one year of age.,false,,,http://purl.obolibrary.org/obo/DOID_0050701,,,,,,,,An electroclinical syndrome with onset in infancy occurring between birth and one year of age.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050703,lschriml,2012-04-11T11:48:18Z,,,,,disease_ontology,,DOID:0050703,,,,,,,,,,,,,,,,,,,infancy electroclinical syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050704,"[""childhood electroclinical syndrome""]",,An electroclinical syndrome with onset in childhood between one and 12 years of age.,false,,,http://purl.obolibrary.org/obo/DOID_0050701,,,,,,,,An electroclinical syndrome with onset in childhood between one and 12 years of age.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050704,lschriml,2012-04-11T11:48:18Z,,,,,disease_ontology,,DOID:0050704,,,,,,,,,,,,,,,,,,,childhood electroclinical syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050700,"[""cardiomyopathy""]",,A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle.,false,,,http://purl.obolibrary.org/obo/DOID_114,,,,,,,,A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050700,lschriml,2012-01-03T02:54:11Z,,SNOMEDCT_US_2016_03_01:57809008|ICD9CM:425.9|SNOMEDCT_US_2016_03_01:155353006|SNOMEDCT_US_2016_03_01:89600009|NCI:C53654|UMLS_CUI:C0878544|SNOMEDCT_US_2016_03_01:195035002|ICD10CM:I51.5|SNOMEDCT_US_2016_03_01:266244008|NCI:C34830|SNOMEDCT_US_2016_03_01:266301006|MESH:D009202|SNOMEDCT_US_2016_03_01:85898001|SNOMEDCT_US_2016_03_01:89461002|ICD10CM:I42.9|SNOMEDCT_US_2016_03_01:195037005|SNOMEDCT_US_2016_03_01:20072003|UMLS_CUI:C0033141|UMLS_CUI:C0036529|ICD10CM:I42|ICD9CM:425|SNOMEDCT_US_2016_03_01:155351008,Cardiomyopathies,,disease_ontology,,DOID:0050700,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,MESH:D009202 added from NeuroDevNet [WAK].,,cardiomyopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050705,"[""adolescence-adult electroclinical syndrome""]",,An electroclinical syndrome with onset in adolescence and adulthood.,false,,,http://purl.obolibrary.org/obo/DOID_0050701,,,,,,,,An electroclinical syndrome with onset in adolescence and adulthood.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050705,lschriml,2012-04-11T11:48:18Z,,,,,disease_ontology,,DOID:0050705,,,,,,,,,,,,,,,,,,,adolescence-adult electroclinical syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000973,"[""respiratory mucosa""]",,The mucous membrane lining the respiratory tract.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000886,,,,,,,,The mucous membrane lining the respiratory tract.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000973,,,,,,,BrendaTissueOBO,,BTO:0000973,,,,,,,,,,,,,,,,,,,respiratory mucosa,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200713,"[""OR9A4 gene""]",,"An olfactory receptor 9A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGU2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 9A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGU2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200713,,,,,,,,,,,,,,,,130075,OR9A4,,,,,,,,,,,OR9A4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000145,"[""EPHB6 kinase domain""]",,EPH receptor B6; EPHB6; HEP; MGC129910; MGC129911,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,EPH receptor B6; EPHB6; HEP; MGC129910; MGC129911,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000145,,,,,,,,,,,,,,,,,,,200147,,,,,,,,,EPHB6 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002347,"[""metatarsal bone""]",,"Any of the five bones extending from the tarsus to the phalanges of the toes, being numbered in the same sequence from the most medial to the most lateral.",false,,,http://purl.obolibrary.org/obo/UBERON_0001474|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000140,,,,,,,,"Any of the five bones extending from the tarsus to the phalanges of the toes, being numbered in the same sequence from the most medial to the most lateral.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002347,,,,,,,BrendaTissueOBO,ossa metatarsalia|metatarsal|ossa metatarsi,BTO:0002347,,,,,,,,,,,,,,,,,,,metatarsal bone,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001619,"[""skin fibroblast cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000453,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001619,,,,,,,BrendaTissueOBO,,BTO:0001619,,,,,,,,,,,,,,,,,,,skin fibroblast cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000292,"[""PHE90 in KCC2D""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000292,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE90 in KCC2D,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300206,"[""VPS15 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300206,,,,,,,,,,,,,,,,,,,,,,,,,,,,VPS15 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100586,"[""Putative hexokinase HKDC1""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100586,,,,,,,,,,,,,,,,,HKDC1,,,Q2TB90,,,,,,,,Putative hexokinase HKDC1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217462,"[""Peroxisome proliferator-activated receptors gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00200002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217462,,,,,,,,,,,,,,,,,,,,,,,,,,,,Peroxisome proliferator-activated receptors gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200130,"[""GLRB gene""]",,"This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400529,,,,,,,,"This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200130,,,,,,,,,,,,,,,,2743,GLRB,,,,,,,,,,,GLRB gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400146,"[""DAPK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400146,,,,,,,,,,,,,,,,,,,,,,,,,,,,DAPK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000223,"[""KKCC1 kinase domain""]",,"Calcium/calmodulin-dependent protein kinase kinase 1, CaM-kinase IV kinase; CAMKK1; CAMKKA; DKFZp761M0423; MGC34095",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Calcium/calmodulin-dependent protein kinase kinase 1, CaM-kinase IV kinase; CAMKK1; CAMKKA; DKFZp761M0423; MGC34095",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000223,,,,,,,,,,,,,,,,,,,200068,,,,,,,,,KKCC1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000045,"[""LEU122 in NEK6""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000045,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU122 in NEK6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000628,"[""inflorescence""]",,A flower cluster with a definite arrangement.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A flower cluster with a definite arrangement.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000628,,,,,,,BrendaTissueOBO,flower cluster,BTO:0000628,,,,,,,,,,,,,,,,,,,inflorescence,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100784,"[""Taste receptor type 2 member 38""]",,"A taste receptor type 2 member 38 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59533] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300014,,,,,,,,"A taste receptor type 2 member 38 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59533] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100784,,,,https://pharos.nih.gov/idg/targets/P59533,,,,,,,,,,,,,TAS2R38,PTC,,P59533,,,,,,,,Taste receptor type 2 member 38,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100091,"[""Calcium release-activated calcium channel protein 1""]",,"A calcium release-activated calcium channel protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96D31] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300344,,,,,,,,"A calcium release-activated calcium channel protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96D31] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100091,,,,https://pharos.nih.gov/idg/targets/Q96D31,,,,,,,,,,,,,ORAI1,CRACM1|TMEM142A,,Q96D31,,,,,,,,Calcium release-activated calcium channel protein 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000091,"[""CLK2 kinase domain""]",,Dual specificity protein kinase CLK2; CDC-like kinase 2; CLK2; hCLK2; MGC61500,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Dual specificity protein kinase CLK2; CDC-like kinase 2; CLK2; hCLK2; MGC61500,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000091,,,,,,,,,,,,,,,,,,,200091,,,,,,,,,CLK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1591,"[""renovascular hypertension""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1073,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1591,,,,MESH:D006978|UMLS_CUI:C0020545|SNOMEDCT_US_2016_03_01:123799005|SNOMEDCT_US_2016_03_01:194790006|ICD10CM:I15.0|NCI:C85044,Renovascular hypertension (disorder),,disease_ontology,,DOID:1591,,,,,,,,,,,,,,,,,,,renovascular hypertension,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300209,"[""SGK493 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300209,,,,,,,,,,,,,,,,,,,,,,,,,,,,SGK493 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80307,"[""Kisspeptin-10""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG COMPOUND:C16093,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80307,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80307,,,,,Kisspeptin-10,,CHEBI:80307,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200239,"[""LPAR2 gene""]",,"A lysophosphatidic acid receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HBW0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402007,,,,,,,,"A lysophosphatidic acid receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HBW0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200239,,,,,,,,,,,,,,,,9170,LPAR2,EDG4|LPA2,,,,,,,,,,LPAR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004958,"[""F9-12 cell""]",,"The yeast genomic DNA from the strain F9 was transferred to the established mouse fibroblast cell line L A-9 by fusion with yeast spheroplasts followed by selection with G418 to select for cells which had taken up yeast DNA. Seventeen independent cell lines, called F9-1 to F9-17, were grown up from colonies on separate plates.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001926,,,,,,,,"The yeast genomic DNA from the strain F9 was transferred to the established mouse fibroblast cell line L A-9 by fusion with yeast spheroplasts followed by selection with G418 to select for cells which had taken up yeast DNA. Seventeen independent cell lines, called F9-1 to F9-17, were grown up from colonies on separate plates.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004958,Marion Gremse,2010-10-28T12:29:08Z,,,,,BrendaTissueOBO,,BTO:0004958,,,,,,,,,,,,,,,,,,,F9-12 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100130,"[""Ephrin type-a receptor 6""]",,"An ephrin type-A receptor 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UF33] |ephrin type-a receptor 6 (EPHA6)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300153,,,,,,,,"An ephrin type-A receptor 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UF33] |ephrin type-a receptor 6 (EPHA6)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100130,,,,https://pharos.nih.gov/idg/targets/Q9UF33,,,,,,,,,,,,,EPHA6,EHK2|HEK12,,Q9UF33,,,,,,,,Ephrin type-a receptor 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100198,"[""Potassium voltage-gated channel subfamily e member 3""]",,"A potassium voltage-gated channel subfamily E member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y6H6] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300445,,,,,,,,"A potassium voltage-gated channel subfamily E member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y6H6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100198,,,,https://pharos.nih.gov/idg/targets/Q9Y6H6,,,,,,,,,,,,,KCNE3,,,Q9Y6H6,,,,,,,,Potassium voltage-gated channel subfamily e member 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200699,"[""OR8H3 gene""]",,"An olfactory receptor 8H3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N146] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 8H3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N146] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200699,,,,,,,,,,,,,,,,390152,OR8H3,,,,,,,,,,,OR8H3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000912,"[""nasal mucosa""]",,"The mucosa, or mucous membrane, is a type of tissue that lines the nasal cavity. Mucous membranes are usually moist tissues that are bathed by secretions such as in the nose.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000973|http://purl.obolibrary.org/obo/BTO_0000419,,,,,,,,"The mucosa, or mucous membrane, is a type of tissue that lines the nasal cavity. Mucous membranes are usually moist tissues that are bathed by secretions such as in the nose.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000912,,,,,,,BrendaTissueOBO,nasal cavity epithelium,BTO:0000912,,,,,,,,,,,,,,,,,,,nasal mucosa,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000029,"[""ACVR1B kinase domain""]",,"Activin A receptor, type IB; ACTRIB; ACVR1B; ACVRLK4; ALK4; SKR2",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Activin A receptor, type IB; ACTRIB; ACVR1B; ACVRLK4; ALK4; SKR2",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000029,,,,,,,,,,,,,,,,,,,200028,,,,,,,,,ACVR1B kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117488,"[""Nuclear receptor subfamily 1 group d member 1""]",,"A nuclear receptor subfamily 1 group D member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P20393] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117463,,,,,,,,"A nuclear receptor subfamily 1 group D member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P20393] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117488,,,,https://pharos.nih.gov/idg/targets/P20393,,,,,,,,,,,,,NR1D1,HREV,,P20393,,,,,,,,Nuclear receptor subfamily 1 group d member 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100191,"[""Probable G-protein coupled receptor 33""]",,"A G-protein coupled receptor 33 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q49SQ1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300057,,,,,,,,"A G-protein coupled receptor 33 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q49SQ1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100191,,,,https://pharos.nih.gov/idg/targets/Q49SQ1,,,,,,,,,,,,,GPR33,,,Q49SQ1,,,,,,,,Probable G-protein coupled receptor 33,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000226,"[""MET94 in MAP4K5""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000226,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET94 in MAP4K5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400035,"[""Cannabinoid receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400035,,,,,,,,,,,,,,,,,,,,,,,,,,,,Cannabinoid receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000130,"[""5-oxo-20-HETE""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000130,,,,,,,,,,,,,,,,,,,,,,,,,,,,5-oxo-20-HETE,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217465,"[""Liver x receptor-like receptors gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00200002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217465,,,,,,,,,,,,,,,,,,,,,,,,,,,,Liver x receptor-like receptors gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200296,"[""SCN4B gene""]",,"The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400470,,,,,,,,"The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200296,,,,,,,,,,,,,,,,6330,SCN4B,,,,,,,,,,,SCN4B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001294,"[""sporulating cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001434,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001294,,,,,,,BrendaTissueOBO,,BTO:0001294,,,,,,,,,,,,,,,,,,,sporulating cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000413,"[""TYR241 in IRAK3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_46858,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000413,,,,,,,,,,,,,,,,,,,,,,,,,,,,TYR241 in IRAK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400113,"[""STE group gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400102,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400113,,,,,,,,,,,,,,,,,,,,,,,,,,,,STE group gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200296,"[""OR10AG1 gene""]",,"An olfactory receptor 10AG1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH19] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10AG1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH19] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200296,,,,,,,,,,,,,,,,282770,OR10AG1,,,,,,,,,,,OR10AG1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000206,"[""cartilage""]",,"A specialized, fibrous connective tissue, forming most of the temporary skeleton of the embryo, providing a model in which most of the bones develop, and constituting an important part of the growth mechanism of the organism. It exists in several types, the most important of which are hyaline cartilage, elastic cartilage, and fibrocartilage. Also used as a general term to designate a mass of such tissue in a particular site in the body.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000421,,,,,,,,"A specialized, fibrous connective tissue, forming most of the temporary skeleton of the embryo, providing a model in which most of the bones develop, and constituting an important part of the growth mechanism of the organism. It exists in several types, the most important of which are hyaline cartilage, elastic cartilage, and fibrocartilage. Also used as a general term to designate a mass of such tissue in a particular site in the body.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000206,,,,,,,BrendaTissueOBO,,BTO:0000206,,,,,,,,,,,,,,,,,,,cartilage,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100047,"[""R420 in PIK3CA(C420R)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100047,,,,,,,,,,,,,,,,,,,,,,,,,,,,R420 in PIK3CA(C420R),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200075,"[""CLCN4 gene""]",,"The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. [provided by RefSeq, Mar 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400398,,,,,,,,"The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. [provided by RefSeq, Mar 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200075,,,,,,,,,,,,,,,,1183,CLCN4,,,,,,,,,,,CLCN4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200813,"[""TSHR gene""]",,"A thyrotropin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P16473] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A thyrotropin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P16473] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200813,,,,,,,,,,,,,,,,7253,TSHR,LGR3,,,,,,,,,,TSHR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100765,"[""Sphingosine 1-phosphate receptor 3""]",,"A sphingosine 1-phosphate receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99500] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A sphingosine 1-phosphate receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99500] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100765,,,,https://pharos.nih.gov/idg/targets/Q99500,,,,,,,,,,,,,S1PR3,EDG3,,Q99500,,,,,,,,Sphingosine 1-phosphate receptor 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100117,"[""Dual specificity tyrosine-phosphorylation-regulated kinase 4""]",,"A dual specificity tyrosine-phosphorylation-regulated kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NR20] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300267,,,,,,,,"A dual specificity tyrosine-phosphorylation-regulated kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NR20] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100117,,,,https://pharos.nih.gov/idg/targets/Q9NR20,,,,,,,,,,,,,DYRK4,,,Q9NR20,,,,,,,,Dual specificity tyrosine-phosphorylation-regulated kinase 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_36005,"[""Docosahexaenoic acid""]",docosahexaenoic acids|DHA|C22H32O2,"
Any C22 polyunsaturated fatty acid containing six double bonds.
",false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,,"
Any C22 polyunsaturated fatty acid containing six double bonds.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,docosahexaenoic acid,,chebi_ontology,docosahexaenoic acids|DHA|C22H32O2,,,CHEBI:36005,,,,,,,,,,,,,,,,,,,,,,,CHEBI:36005,,,,,docosahexaenoic acid|Docosahexaenoic acid,,CHEBI:36005,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000374,"[""bone cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000374,,,,,,,BrendaTissueOBO,,BTO:0000374,,,,,,,,,,,,,,,,,,,bone cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200722,"[""HCRTR2 gene""]",,An orexin receptor type 2 that is encoded in the genome of human. [Reactome:REACT_17071] ,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,An orexin receptor type 2 that is encoded in the genome of human. [Reactome:REACT_17071] ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200722,,,,,,,,,,,,,,,,3062,HCRTR2,,,,,,,,,,,HCRTR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300179,"[""RSKL family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300179,,,,,,,,,,,,,,,,,,,,,,,,,,,,RSKL family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000140,"[""MET174 in MLK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000140,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET174 in MLK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100304,"[""Olfactory receptor 10G7""]",,"An olfactory receptor 10G7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10G7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100304,,,,https://pharos.nih.gov/idg/targets/Q8NGN6,,,,,,,,,,,,,OR10G7,,,Q8NGN6,,,,,,,,Olfactory receptor 10G7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000086,"[""CCL22""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000086,,,,,,,,,,,,,,,,,,,,,,,,,,,,CCL22,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100000,"[""mutated residue""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_33700,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,mutated residue,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200456,"[""OR5H15 gene""]",,"An olfactory receptor 5H15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NDH6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5H15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NDH6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200456,,,,,,,,,,,,,,,,403274,OR5H15,,,,,,,,,,,OR5H15 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200070,"[""CDK4 gene""]",,"The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400260,,,,,,,,"The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200070,,,,,,,,,,,,,,,,1019,CDK4,,,,,,,,,,,CDK4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100316,"[""Mitogen-activated protein kinase 3""]",,"A mitogen-activated protein kinase 3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P27361] |mitogen-activated protein kinase 3 (MK03)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300292,,,,,,,,"A mitogen-activated protein kinase 3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P27361] |mitogen-activated protein kinase 3 (MK03)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100316,,,,https://pharos.nih.gov/idg/targets/P27361,,,,,,,,,,,,,MAPK3,ERK1|PRKM3,,P27361,,,,,,,,Mitogen-activated protein kinase 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200291,"[""MAP3K9 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400284,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200291,,,,,,,,,,,,,,,,4293,MAP3K9,MLK1|PRKE1,,,,,,,,,,MAP3K9 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217561,"[""ESR1 gene""]",,"This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_00217472,,,,,,,,"This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217561,,,,,,,,,,,,,,,,2099,ESR1,ESR|NR3A1,,,,,,,,,,ESR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2959,"[""hyperimmunoglobulin syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2115,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2959,,,,NCI:C27579|UMLS_CUI:C1334069,,,disease_ontology,,DOID:2959,,,,,,,,,,,,,,,,,,,hyperimmunoglobulin syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000206,"[""MET82 in CSNK1D""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000206,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET82 in CSNK1D,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400328,"[""Neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400328,,,,,,,,,,,,,,,,,,,,,,,,,,,,"Neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family gene",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200624,"[""OR5G3 gene""]",,"An olfactory receptor 5G3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C626] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5G3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C626] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200624,,,,,,,,,,,,,,,,81193,OR5G3,OR5G3P|OR5G6P,,,,,,,,,,OR5G3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100161,"[""G protein-activated inward rectifier potassium channel 4""]",,"A G protein-activated inward rectifier potassium channel 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48544] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300432,,,,,,,,"A G protein-activated inward rectifier potassium channel 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48544] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100161,,,,https://pharos.nih.gov/idg/targets/P48544,,,,,,,,,,,,,KCNJ5,GIRK4,,P48544,,,,,,,,G protein-activated inward rectifier potassium channel 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200775,"[""SUCNR1 gene""]",,"A succinate receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BXA5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A succinate receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BXA5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200775,,,,,,,,,,,,,,,,56670,SUCNR1,GPR91,,,,,,,,,,SUCNR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000917,"[""needle""]",,A needle-shaped leaf (as of a conifer).,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000713,,,,,,,,A needle-shaped leaf (as of a conifer).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000917,,,,,,,BrendaTissueOBO,,BTO:0000917,,,,,,,,,,,,,,,,,,,needle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300454,"[""NR3B/GRIN3B subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300454,,,,,,,,,,,,,,,,,,,,,,,,,,,,NR3B/GRIN3B subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1625,"[""breast adenoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060082|http://purl.obolibrary.org/obo/DOID_657,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1625,,,,SNOMEDCT_US_2016_03_01:269640007|NCI:C40382|UMLS_CUI:C1328385,Ademoma - breast,,disease_ontology,,DOID:1625,,,,,,,,,,,,,,,,,,,breast adenoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000095,"[""MET105 in MINK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000095,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET105 in MINK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400561,"[""Kv7.1/KCNQ1 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400449,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400561,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv7.1/KCNQ1 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200229,"[""HCAR3 gene""]",,"A hydroxycarboxylic acid receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49019] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400060,,,,,,,,"A hydroxycarboxylic acid receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49019] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200229,,,,,,,,,,,,,,,,8843,HCAR3,GPR109B|HCA3|HM74B|NIACR2,,,,,,,,,,HCAR3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100357,"[""Putative olfactory receptor 14l1""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100357,,,,https://pharos.nih.gov/idg/targets/Q8NHC6,,,,,,,,,,,,,OR14L1P,OR5AV1P,,Q8NHC6,,,,,,,,Putative olfactory receptor 14l1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100010,"[""Activin receptor type-1c""]",,"An activin receptor type-1C that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8NER5] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300246,,,,,,,,"An activin receptor type-1C that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8NER5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100010,,,,https://pharos.nih.gov/idg/targets/Q8NER5,,,,,,,,,,,,,ACVR1C,ALK7,,Q8NER5,,,,,,,,Activin receptor type-1c,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000447,"[""feather""]",,Any of the light horny epidermal outgrowths that form the external covering of the body of birds and that consist of a shaft bearing on each side a series of barbs which bear barbules which in turn bear barbicels commonly ending in hooked hamuli and interlocking with the barbules of an adjacent barb to link the barbs into a continuous vane.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Any of the light horny epidermal outgrowths that form the external covering of the body of birds and that consist of a shaft bearing on each side a series of barbs which bear barbules which in turn bear barbicels commonly ending in hooked hamuli and interlocking with the barbules of an adjacent barb to link the barbs into a continuous vane.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000447,,,,,,,BrendaTissueOBO,,BTO:0000447,,,,,,,,,,,,,,,,,,,feather,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11476,"[""osteoporosis""]",,A bone resorption disease characterized by decreased density of normally mineralized bone which results_in the thinning of bone tissue and decreased mechanical strength.,false,,,http://purl.obolibrary.org/obo/DOID_0080011,,,,,,,,A bone resorption disease characterized by decreased density of normally mineralized bone which results_in the thinning of bone tissue and decreased mechanical strength.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11476,,,,MESH:D015663|ICD9CM:733.00|SNOMEDCT_US_2016_03_01:156825006|NCI:C3298|ICD9CM:733.0|ICD10CM:M81.0|OMIM:166710|SNOMEDCT_US_2016_03_01:64859006|UMLS_CUI:C0029456|MESH:D010024|EFO:0003882|SNOMEDCT_US_2016_03_01:203440004|SNOMEDCT_US_2016_03_01:203428004,,,disease_ontology,,DOID:11476,,,,,,,,,,,,,,,,,Xref MGI.,,osteoporosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000135,"[""aorta""]",,The great arterial trunk that carries blood from the heart to be distributed by branch arteries through the body.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000573,,,,,,,,The great arterial trunk that carries blood from the heart to be distributed by branch arteries through the body.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000135,,,,,,,BrendaTissueOBO,trunk of systemic arterial tree|trunk of aortic tree,BTO:0000135,,,,,,,,,,,,,,,,,,,aorta,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300429,"[""KCNJ2 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300429,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ2 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2494,"[""angiodysplasia""]",,A vascular disease that is characterized as a small vascular malformation of the gut.,false,,,http://purl.obolibrary.org/obo/DOID_178,,,,,,,,A vascular disease that is characterized as a small vascular malformation of the gut.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2494,,,DOID:12071,SNOMEDCT_US_2016_03_01:71072006|ICD9CM:537.83|UMLS_CUI:C0156091|UMLS_CUI:C0085411|MESH:D016888,angiodysplasia of stomach and duodenum with hemorrhage,,disease_ontology,,DOID:2494,,,,,,,,,,,,,,,,,,,angiodysplasia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000394,"[""RSK1(Kin.Dom.1-N-terminal) kinase domain""]",,"Ribosomal protein S6 kinase, 90kDa, polypeptide 1; HU-1; MAPKAPK1A; RPS6KA1; RSK; RSK1; RSK3",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Ribosomal protein S6 kinase, 90kDa, polypeptide 1; HU-1; MAPKAPK1A; RPS6KA1; RSK; RSK1; RSK3",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000394,,,,,,,,,,,,,,,,,,,"200384, 200399",,,,,,,,,RSK1(Kin.Dom.1-N-terminal) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2999,"[""granulosa cell tumor""]",,,false,,,http://purl.obolibrary.org/obo/DOID_192|http://purl.obolibrary.org/obo/DOID_2394,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2999,,,DOID:5333,UMLS_CUI:C0334401|SNOMEDCT_US_2016_03_01:18861007|UMLS_CUI:C0018206|NCI:C3070|SNOMEDCT_US_2016_03_01:189734000|NCI:C4205|SNOMEDCT_US_2016_03_01:46585005|MESH:D006106,"Granulosa cell tumor, adult type (morphologic abnormality)|Granulosa cell neoplasm|malignant granulosa cell neoplasm|Granulosa cell tumour, sarcomatoid",,disease_ontology,,DOID:2999,,,,,,,,,,,,,,,,,,,granulosa cell tumor,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400472,"[""SCN7A subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400369,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400472,,,,,,,,,,,,,,,,,,,,,,,,,,,,SCN7A subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8499,"[""night blindness""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5679,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8499,,,,SNOMEDCT_US_2016_03_01:193693008|SNOMEDCT_US_2016_03_01:155144006|SNOMEDCT_US_2016_03_01:65194006|NCI:C37997|MESH:D009755|ICD10CM:H53.60|ICD9CM:368.6|UMLS_CUI:C0028077|ICD9CM:368.60|NCI:C34850|SNOMEDCT_US_2016_03_01:193686009|SNOMEDCT_US_2016_03_01:75390007|ICD10CM:H53.6,,,disease_ontology,,DOID:8499,,,,,,,,,,,,,,,,,,,night blindness,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200504,"[""OR1P1 gene""]",,"An olfactory receptor 1P1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH06] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1P1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH06] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200504,,,,,,,,,,,,,,,,8391,OR1P1,OR1P1P,,,,,,,,,,OR1P1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100146,"[""Fas-activated serine/threonine kinase""]",,"A Fas-activated serine/threonine kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14296] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300156,,,,,,,,"A Fas-activated serine/threonine kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14296] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100146,,,,https://pharos.nih.gov/idg/targets/Q14296,,,,,,,,,,,,,FASTK,,,Q14296,,,,,,,,Fas-activated serine/threonine kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000145,"[""MET193 in MLK3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000145,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET193 in MLK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000225,"[""KPCD1 kinase domain""]",,Protein kinase D1; PKCM; PKC-MU; PKD; PKD1; PRKCM; PRKD1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Protein kinase D1; PKCM; PKC-MU; PKD; PKD1; PRKCM; PRKD1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000225,,,,,,,,,,,,,,,,,,,200359,,,,,,,,,KPCD1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80328,"[""Gastrin-releasing peptide""]",GRP,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG COMPOUND:C16115,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,GRP,,,CHEBI:80328,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80328,,,,,Gastrin-releasing peptide,,CHEBI:80328,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100021,"[""Rac-gamma serine/threonine-protein kinase""]",,"RAC-gamma serine/threonine-protein kinase (AKT3)  with  no mutation  in a nonphosphorylated state|A RAC-gamma serine/threonine-protein kinase that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9Y243] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300121,,,,,,,,"RAC-gamma serine/threonine-protein kinase (AKT3)  with  no mutation  in a nonphosphorylated state|A RAC-gamma serine/threonine-protein kinase that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9Y243] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100021,,,,https://pharos.nih.gov/idg/targets/Q9Y243,,,,,,,,,,,,,AKT3,PKBG,,Q9Y243,,,,,,,,Rac-gamma serine/threonine-protein kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4948,"[""gallbladder carcinoma""]",,A gallbladder cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.,false,,,http://purl.obolibrary.org/obo/DOID_305|http://purl.obolibrary.org/obo/DOID_3121,,,,,,,,A gallbladder cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4948,,,,UMLS_CUI:C0235782|SNOMEDCT_US_2016_03_01:187782001|NCI:C3844|SNOMEDCT_US_2016_03_01:372140005|SNOMEDCT_US_2016_03_01:255085003|SNOMEDCT_US_2016_03_01:93810008,carcinoma of gallbladder (disorder)|carcinoma gallbladder|cancer of the gallbladder,,disease_ontology,,DOID:4948,,,,,,,,,,,,,,,,,,,gallbladder carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200265,"[""LATS2 gene""]",,"This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400181,,,,,,,,"This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200265,,,,,,,,,,,,,,,,26524,LATS2,KPM,,,,,,,,,,LATS2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200017,"[""CHRNB4 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400501,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200017,,,,,,,,,,,,,,,,1143,CHRNB4,,,,,,,,,,,CHRNB4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300565,"[""Kv7.5/KCNQ5 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300449,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300565,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv7.5/KCNQ5 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300184,"[""LRRK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300107,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300184,,,,,,,,,,,,,,,,,,,,,,,,,,,,LRRK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9164,"[""achalasia""]",,An esophageal disease that is characterized by an inability of the esophagus to move food toward the stomach resulting from the lower esophogeal sphincter not fully relaxing during swallowing.,false,,,http://purl.obolibrary.org/obo/DOID_6050,,,,,,,,An esophageal disease that is characterized by an inability of the esophagus to move food toward the stomach resulting from the lower esophogeal sphincter not fully relaxing during swallowing.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9164,,,,SNOMEDCT_US_2016_03_01:45564002|SNOMEDCT_US_2016_03_01:17460002|UMLS_CUI:C0014848|ICD9CM:530.0|NCI:C84699|OMIM:200400|ICD10CM:K22.0|SNOMEDCT_US_2016_03_01:155672003|MESH:D004931,cardiospasm|hypertensive lower esophageal sphincter|achalasia of cardia|achalasia of esophagus|esophageal achalasia|Lack of reflex relaxation of lower oesophageal sphincter,,disease_ontology,,DOID:9164,,,,,,,,,,,,,,,,,,,achalasia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100238,"[""Potassium voltage-gated channel subfamily s member 2""]",,"A voltage-gated potassium channel KCNS2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9ULS6] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300567,,,,,,,,"A voltage-gated potassium channel KCNS2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9ULS6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100238,,,,https://pharos.nih.gov/idg/targets/Q9ULS6,,,,,,,,,,,,,KCNS2,KIAA1144,,Q9ULS6,,,,,,,,Potassium voltage-gated channel subfamily s member 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300276,"[""PKC alpha subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300175,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300276,,,,,,,,,,,,,,,,,,,,,,,,,,,,PKC alpha subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2415,"[""benign skin melanocytic nevus""]",,,[true],,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2415,,,DOID:2418|DOID:5901|DOID:191,,benign melanocytic naevus of skin|benign melanoma|Magnocellular nevus|cutaneous melanocytic neoplasm|Magnocellular nevus (morphologic abnormality)|benign melanocytic naevus|melanocytic neoplasm (disorder)|melanocytic tumor of skin (disorder)|benign nevus of skin|Naevus - benign|melanocytoma|melanocytic neoplasm of skin|benign melanocytic nevus|melanocytic neoplasm,,disease_ontology,,DOID:2415,,,,,,,,,,,,,,,,,,,benign skin melanocytic nevus,true,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001134,"[""protonema""]",,The primary usually filamentous thalloid stage of the gametophyte in mosses and in some liverworts comparable to the prothallium in ferns.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000495,,,,,,,,The primary usually filamentous thalloid stage of the gametophyte in mosses and in some liverworts comparable to the prothallium in ferns.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001134,,,,,,,BrendaTissueOBO,,BTO:0001134,,,,,,,,,,,,,,,,,,,protonema,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004171,"[""MOLT-13 cell""]",,"Human T cell leukemia cell line; established from the bone marrow of a 2-year-old girl with T-ALL (T cell acute lymphoblastic leukemia, FAB L2) at relapse in 1983.",false,,,http://purl.obolibrary.org/obo/BTO_0002504|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Human T cell leukemia cell line; established from the bone marrow of a 2-year-old girl with T-ALL (T cell acute lymphoblastic leukemia, FAB L2) at relapse in 1983.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004171,,,,,,,BrendaTissueOBO,,BTO:0004171,,,,,,,,,,,,,,,,,,,MOLT-13 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200585,"[""OR4E2 gene""]",,"An olfactory receptor 4E2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4E2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200585,,,,,,,,,,,,,,,,26686,OR4E2,,,,,,,,,,,OR4E2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000854,"[""zygote""]",,Diploid cell resulting from the fusion of male and female gametes at fertilization.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000174,,,,,,,,Diploid cell resulting from the fusion of male and female gametes at fertilization.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000854,,,,,,,BrendaTissueOBO,fertilized egg stage,BTO:0000854,,,,,,,,,,,,,,,,,,,zygote,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2566,"[""corneal dystrophy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_10124,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2566,,,DOID:8944,ICD9CM:371.50|UMLS_CUI:C0010036|SNOMEDCT_US_2016_03_01:193832003|NCI:C34513|ICD10CM:H18.50|SNOMEDCT_US_2016_03_01:193831005|NCI:C34512|MESH:D003317|SNOMEDCT_US_2016_03_01:193842001|ICD10CM:H18.5|ICD9CM:371.5|UMLS_CUI:C0010035|SNOMEDCT_US_2016_03_01:5587004|SNOMEDCT_US_2016_03_01:77797009,,,disease_ontology,,DOID:2566,,,,,,,,,,,,,,,,,,,corneal dystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100237,"[""Protein kinase c beta type""]",,"A protein kinase C beta type that is encoded in the genome of human. [PRO:CNA, UniProtKB:P05771] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300276,,,,,,,,"A protein kinase C beta type that is encoded in the genome of human. [PRO:CNA, UniProtKB:P05771] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100237,,,,https://pharos.nih.gov/idg/targets/P05771,,,,,,,,,,,,,PRKCB,PKCB|PRKCB1,,P05771,,,,,,,,Protein kinase c beta type,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300435,"[""KCNJ9 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300435,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ9 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000520,"[""gizzard""]",,1: The muscular enlargement of the alimentary canal of birds that has usually thick muscular walls and a tough horny lining for grinding the food and when the crop is present follows it and the proventriculus. 2: A thickened part of the alimentary canal in some animals (as an insect or an earthworm) that is similar in function to the crop of a bird.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002263,,,,,,,,1: The muscular enlargement of the alimentary canal of birds that has usually thick muscular walls and a tough horny lining for grinding the food and when the crop is present follows it and the proventriculus. 2: A thickened part of the alimentary canal in some animals (as an insect or an earthworm) that is similar in function to the crop of a bird.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000520,,,,,,,BrendaTissueOBO,,BTO:0000520,,,,,,,,,,,,,,,,,,,gizzard,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100141,"[""Adhesion G-protein coupled receptor G7""]",,"A G-protein coupled receptor 128 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96K78] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,"A G-protein coupled receptor 128 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96K78] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100141,,,,https://pharos.nih.gov/idg/targets/Q96K78,,,,,,,,,,,,,GPR128,ADGRG7,,Q96K78,,,,,,,,Adhesion G-protein coupled receptor G7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000218,"[""BALB/3T3 cell""]",,The BALB/3T3 clone A31 is one of several cell lines (see BALB/3T12) developed in 1968 from disaggregated 14- to 17-day-old BALB/c mouse embryos.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001958,,,,,,,,The BALB/3T3 clone A31 is one of several cell lines (see BALB/3T12) developed in 1968 from disaggregated 14- to 17-day-old BALB/c mouse embryos.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000218,,,,,,,BrendaTissueOBO,BALB/c 3T3 cell|BALBc/3T3 cell|BALB/3T3 clone A31,BTO:0000218,,,,,,,,,,,,,,,,,,,BALB/3T3 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200535,"[""TRIB1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400237,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200535,,,,,,,,,,,,,,,,10221,TRIB1,C8FW|GIG2|TRB1,,,,,,,,,,TRIB1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000429,"[""VAL804 in RET(V804M)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000429,,,,,,,,,,,,,,,,,,,,,,,,,,,,VAL804 in RET(V804M),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000240,"[""PHE107 in PHKG2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000240,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE107 in PHKG2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100314,"[""Olfactory receptor 10J4""]",,"An olfactory receptor 10J4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C629] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10J4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C629] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100314,,,,https://pharos.nih.gov/idg/targets/P0C629,,,,,,,,,,,,,OR10J4,OR10J4P,,P0C629,,,,,,,,Olfactory receptor 10J4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000424,"[""erythrocyte""]",,Any of the hemoglobin-containing cells that carry oxygen to the tissues and are responsible for the red color of vertebrate blood.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000574,,,,,,,,Any of the hemoglobin-containing cells that carry oxygen to the tissues and are responsible for the red color of vertebrate blood.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000424,,,,,,,BrendaTissueOBO,red blood corpuscle|RBC|red blood cell,BTO:0000424,,,,,,,,,,,,,,,,,,,erythrocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000146,"[""brain stem""]",,"The part of the brain composed of the mesencephalon, pons, and medulla oblongata and connecting the spinal cord with the forebrain and cerebrum.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The part of the brain composed of the mesencephalon, pons, and medulla oblongata and connecting the spinal cord with the forebrain and cerebrum.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000146,,,,,,,BrendaTissueOBO,truncus encephalicus|brainstem,BTO:0000146,,,,,,,,,,,,,,,,,,,brain stem,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000098,"[""MET105 in TNIK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000098,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET105 in TNIK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1284,"[""prolapse of female genital organ""]",,,false,,,http://purl.obolibrary.org/obo/DOID_229,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1284,,,,ICD9CM:618.8|ICD9CM:618.89|UMLS_CUI:C0029801,,,disease_ontology,,DOID:1284,,,,,,,,,,,,,,,,,,,prolapse of female genital organ,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12849,"[""autistic disorder""]",,"An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years.",false,,,http://purl.obolibrary.org/obo/DOID_0060041,,,,,,,,"An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12849,,,,OMIM:610676|ICD9CM:299.0|OMIM:607373|OMIM:609378|ICD10CM:F84.0|SNOMEDCT_US_2016_03_01:271450003|OMIM:209850|OMIM:611015|SNOMEDCT_US_2016_03_01:192581001|EFO:0003758|ORDO:106|OMIM:613436|UMLS_CUI:C0004352|SNOMEDCT_US_2016_03_01:38763009|OMIM:300847|OMIM:610908|OMIM:608636|OMIM:615032|OMIM:611016|SNOMEDCT_US_2016_03_01:408856003|SNOMEDCT_US_2016_03_01:34883005|OMIM:610836|OMIM:612100|SNOMEDCT_US_2016_03_01:154878007|OMIM:608049|SNOMEDCT_US_2016_03_01:191691000|SNOMEDCT_US_2016_03_01:43614003|SNOMEDCT_US_2016_03_01:191688000|MESH:D001321|NCI:C97161|OMIM:615091|OMIM:613410|OMIM:300872|OMIM:300496|OMIM:611913|SNOMEDCT_US_2016_03_01:408857007|OMIM:300425|OMIM:300830|OMIM:300495,autism|Kanner's syndrome|autistic disorder of childhood onset|childhood autism|infantile autism,,disease_ontology,,DOID:12849,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,autistic disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000187,"[""Aspirin-triggered resolvin D1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000187,,,,,,,,,,,,,,,,,,,,,,,,,,,,Aspirin-triggered resolvin D1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300034,"[""Chemerin receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300034,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chemerin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_75441,"[""gastrin-17""]","
InChI=1S/C97H124N20O31S/c1-49(2)39-68(114-95(146)71(43-54-46-100-59-18-11-9-16-57(54)59)116-97(148)73-19-12-37-117(73)76(121)48-102-85(136)60-24-30-74(119)104-60)93(144)110-65(29-35-81(130)131)91(142)109-64(28-34-80(128)129)90(141)108-63(27-33-79(126)127)89(140)107-62(26-32-78(124)125)88(139)106-61(25-31-77(122)123)87(138)103-50(3)84(135)113-69(41-52-20-22-55(118)23-21-52)86(137)101-47-75(120)105-70(42-53-45-99-58-17-10-8-15-56(53)58)94(145)111-66(36-38-149-4)92(143)115-72(44-82(132)133)96(147)112-67(83(98)134)40-51-13-6-5-7-14-51/h5-11,13-18,20-23,45-46,49-50,60-73,99-100,118H,12,19,24-44,47-48H2,1-4H3,(H2,98,134)(H,101,137)(H,102,136)(H,103,138)(H,104,119)(H,105,120)(H,106,139)(H,107,140)(H,108,141)(H,109,142)(H,110,144)(H,111,145)(H,112,147)(H,113,135)(H,114,146)(H,115,143)(H,116,148)(H,122,123)(H,124,125)(H,126,127)(H,128,129)(H,130,131)(H,132,133)/t50-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-/m0/s1
|GKDWRERMBNGKCZ-RNXBIMIWSA-N|Little gastrin I|
CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
|Little gastrin|Heptadecapeptide gastrin|G 17|C97H124N20O31S|
Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2
|Gastrin heptadecapeptide","
One of the primary forms of gastrin that is a 17-membered peptide consisting of Glp, Gly, Pro, Trp, Leu, Glu, Glu, Glu, Glu, Glu, Ala, Tyr, Gly, Trp, Met, Asp and Phe-NH2 residues joined in sequence.
",false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,ChemIDplus:60748-06-3|CiteXplore:22138052|Patent:WO2009039995|CiteXplore:22037174|KEGG COMPOUND:C16113|CiteXplore:23349211|CiteXplore:23930120|KEGG COMPOUND:60748-06-3|CiteXplore:22696910|CiteXplore:21030667|CiteXplore:23658576|Wikipedia:Little_gastrin|CiteXplore:23886209|CiteXplore:23311704|Patent:WO2009033729|CiteXplore:21175799|Patent:CA2698980|CiteXplore:22784345|Reaxys:11842134|CiteXplore:21389862|Reaxys:8188172|CiteXplore:23117263,"
One of the primary forms of gastrin that is a 17-membered peptide consisting of Glp, Gly, Pro, Trp, Leu, Glu, Glu, Glu, Glu, Glu, Ala, Tyr, Gly, Trp, Met, Asp and Phe-NH2 residues joined in sequence.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,"
5-oxo-L-prolylglycyl-L-prolyl-L-tryptophyl-L-leucyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alanyl-L-tyrosylglycyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl-L-phenylalaninamide
",,chebi_ontology,"
InChI=1S/C97H124N20O31S/c1-49(2)39-68(114-95(146)71(43-54-46-100-59-18-11-9-16-57(54)59)116-97(148)73-19-12-37-117(73)76(121)48-102-85(136)60-24-30-74(119)104-60)93(144)110-65(29-35-81(130)131)91(142)109-64(28-34-80(128)129)90(141)108-63(27-33-79(126)127)89(140)107-62(26-32-78(124)125)88(139)106-61(25-31-77(122)123)87(138)103-50(3)84(135)113-69(41-52-20-22-55(118)23-21-52)86(137)101-47-75(120)105-70(42-53-45-99-58-17-10-8-15-56(53)58)94(145)111-66(36-38-149-4)92(143)115-72(44-82(132)133)96(147)112-67(83(98)134)40-51-13-6-5-7-14-51/h5-11,13-18,20-23,45-46,49-50,60-73,99-100,118H,12,19,24-44,47-48H2,1-4H3,(H2,98,134)(H,101,137)(H,102,136)(H,103,138)(H,104,119)(H,105,120)(H,106,139)(H,107,140)(H,108,141)(H,109,142)(H,110,144)(H,111,145)(H,112,147)(H,113,135)(H,114,146)(H,115,143)(H,116,148)(H,122,123)(H,124,125)(H,126,127)(H,128,129)(H,130,131)(H,132,133)/t50-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-/m0/s1
|GKDWRERMBNGKCZ-RNXBIMIWSA-N|Little gastrin I|
CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
|Little gastrin|Heptadecapeptide gastrin|G 17|C97H124N20O31S|
Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2
|Gastrin heptadecapeptide",,,CHEBI:75441,,,,,,,,,,,,,,,,,,,,,,,CHEBI:75441,,,,,gastrin-17|Gastrin-17,,CHEBI:75441,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1156,"[""chondrocalcinosis""]",,An arthritis that has_material_basis_in the accumulation of salt crystals located_in joint.,false,,,http://purl.obolibrary.org/obo/DOID_848,,,,,,,,An arthritis that has_material_basis_in the accumulation of salt crystals located_in joint.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1156,,,DOID:13302|DOID:12102|DOID:1834|DOID:14513|DOID:1155|DOID:12090|DOID:13304|DOID:2486|DOID:14220|DOID:13303|DOID:14143|DOID:1945|DOID:13299|DOID:11303|DOID:13301|DOID:13298|DOID:12945,HP:0000934|SNOMEDCT_US_2016_03_01:156881000|MESH:D002805|ICD9CM:712.1|OMIM:118610|SNOMEDCT_US_2016_03_01:60782007|UMLS_CUI:C0033802|SNOMEDCT_US_2016_03_01:268142006|NCI:C34955|SNOMEDCT_US_2016_03_01:201625003|OMIM:118600|ORDO:1416|SNOMEDCT_US_2016_03_01:201624004|OMIM:600668|UMLS_CUI:C0157852|SNOMEDCT_US_2016_03_01:239834007|SNOMEDCT_US_2016_03_01:201636005,pseudogout|calcium pyrophosphate deposition disease,,disease_ontology,,DOID:1156,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,chondrocalcinosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_20067,"[""Beta-D-hydroxybutyric acid""]","beta-Hydroxybutyrate|DL-beta-Hydroxybutyric acid|DL-b-Hydroxybutyric acid|(1)-3-Hydroxybutyric acid|C4H8O3|3-Hydroxy-butanoate|3-Hydroxybutyrate|3-hydroxybutanoic acid|3-Hydroxy-butyrate|beta-hydroxybutyric acid|CC(O)CC(O)=O|
InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)
|beta-Hydroxy-N-butyrate|beta-hydroxybutanoic acid|3-Hydroxy-butyric acid|WHBMMWSBFZVSSR-UHFFFAOYSA-N|3 HBA|beta-hydroxy-n-butyric acid|b-Hydroxybutanoate|b-Hydroxy-N-butyrate|b-Hydroxybutyrate|Biopol|b-Hydroxy-N-butyric acid|beta-Hydroxy-n-butyric acid|b-Hydroxybutanoic acid|3-Hydroxybuttersaeure|beta-Hydroxybutanoate|beta-Hydroxybuttersaeure|3-Hydroxybutanoate|b-Hydroxybutyric acid|3-Hydroxy-butanoic acid|3-OH-butyric acid|DL-3-Hydroxybutyrate|BHBA","
A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
",false,,,http://purl.obolibrary.org/obo/CHEBI_33575,,,,,,,CiteXplore:8412012|CiteXplore:11701757|ChemIDplus:300-85-6|CiteXplore:8969283|CiteXplore:12149510|CiteXplore:6061736|CiteXplore:11043913|CiteXplore:7051864|CiteXplore:12098531|CiteXplore:18502700|MetaCyc:CPD-335|HMDB:HMDB00357|Beilstein:773861|CiteXplore:10855969|Wikipedia:3-hydroxybutyrate|CiteXplore:1126459|CiteXplore:2026685|Reaxys:773861|LIPID MAPS:LMFA01050005|CiteXplore:3884391|CiteXplore:8579834|CiteXplore:11571605|CiteXplore:15363641|Wikipedia:3-Hydroxybutyric acid|CiteXplore:9357925|CiteXplore:9693263|CiteXplore:17579249|CiteXplore:24029555|CiteXplore:16540841|CiteXplore:12067838|CiteXplore:17190852,"
A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,3-hydroxybutyric acid|3-hydroxybutanoic acid,,chebi_ontology,"beta-Hydroxybutyrate|DL-beta-Hydroxybutyric acid|DL-b-Hydroxybutyric acid|(1)-3-Hydroxybutyric acid|C4H8O3|3-Hydroxy-butanoate|3-Hydroxybutyrate|3-hydroxybutanoic acid|3-Hydroxy-butyrate|beta-hydroxybutyric acid|CC(O)CC(O)=O|
InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)
|beta-Hydroxy-N-butyrate|beta-hydroxybutanoic acid|3-Hydroxy-butyric acid|WHBMMWSBFZVSSR-UHFFFAOYSA-N|3 HBA|beta-hydroxy-n-butyric acid|b-Hydroxybutanoate|b-Hydroxy-N-butyrate|b-Hydroxybutyrate|Biopol|b-Hydroxy-N-butyric acid|beta-Hydroxy-n-butyric acid|b-Hydroxybutanoic acid|3-Hydroxybuttersaeure|beta-Hydroxybutanoate|beta-Hydroxybuttersaeure|3-Hydroxybutanoate|b-Hydroxybutyric acid|3-Hydroxy-butanoic acid|3-OH-butyric acid|DL-3-Hydroxybutyrate|BHBA",,,CHEBI:20067,,,,,,,,,,,,,,,,,,,,,,,CHEBI:20067,,,,,3-hydroxybutyric acid|Beta-D-hydroxybutyric acid,,CHEBI:20067,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300174,"[""CAMKK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300174,,,,,,,,,,,,,,,,,,,,,,,,,,,,CAMKK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200300,"[""OR10G2 gene""]",,"An olfactory receptor 10G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200300,,,,,,,,,,,,,,,,26534,OR10G2,,,,,,,,,,,OR10G2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100181,"[""Inhibitor of nuclear factor kappa-b kinase subunit alpha""]",,"inhibitor of nuclear factor kappa-b kinase subunit alpha (IKKA)  with  no mutation  in a nonphosphorylated state|An inhibitor of nuclear factor kappa-B kinase subunit alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15111] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300164,,,,,,,,"inhibitor of nuclear factor kappa-b kinase subunit alpha (IKKA)  with  no mutation  in a nonphosphorylated state|An inhibitor of nuclear factor kappa-B kinase subunit alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15111] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100181,,,,https://pharos.nih.gov/idg/targets/O15111,,,,,,,,,,,,,CHUK,IKKA|TCF16,,O15111,,,,,,,,Inhibitor of nuclear factor kappa-b kinase subunit alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200727,"[""P2RY2 gene""]",,"A P2Y purinoceptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41231] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400100,,,,,,,,"A P2Y purinoceptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41231] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200727,,,,,,,,,,,,,,,,5029,P2RY2,P2RU1,,,,,,,,,,P2RY2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300164,"[""IKK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300164,,,,,,,,,,,,,,,,,,,,,,,,,,,,IKK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100625,"[""Olfactory receptor 5H1""]",,"An olfactory receptor 5H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NKK0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NKK0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100625,,,,https://pharos.nih.gov/idg/targets/A6NKK0,,,,,,,,,,,,,OR5H1,,,A6NKK0,,,,,,,,Olfactory receptor 5H1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2786,"[""cerebellar disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_936,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2786,,,,SNOMEDCT_US_2016_03_01:192867005|SNOMEDCT_US_2016_03_01:49784007|SNOMEDCT_US_2016_03_01:155010002|UMLS_CUI:C0007760|MESH:D002526|SNOMEDCT_US_2016_03_01:267691001|SNOMEDCT_US_2016_03_01:224186005|SNOMEDCT_US_2016_03_01:223176004|SNOMEDCT_US_2016_03_01:307361005,,,disease_ontology,,DOID:2786,,,,,,,,,,,,,,,,,,,cerebellar disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300115,"[""NAK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300115,,,,,,,,,,,,,,,,,,,,,,,,,,,,NAK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100036,"[""Aurora kinase b""]",,"aurora kinase b (AURKB)  with  no mutation  in a nonphosphorylated state|An aurora kinase B that is encoded in the genome of human. [PMID:12719470, PMID:15592459, PMID:15917996, PMID:17617734, PMID:20624902, PMID:21658950, PMID:22732840, PRO:KER] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300130,,,,,,,,"aurora kinase b (AURKB)  with  no mutation  in a nonphosphorylated state|An aurora kinase B that is encoded in the genome of human. [PMID:12719470, PMID:15592459, PMID:15917996, PMID:17617734, PMID:20624902, PMID:21658950, PMID:22732840, PRO:KER] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100036,,,,https://pharos.nih.gov/idg/targets/Q96GD4,,,,,,,,,,,,,AURKB,AIK2|AIM1|AIRK2|ARK2|STK1|STK12|STK5,,Q96GD4,,,,,,,,Aurora kinase b,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200063,"[""CDK17 gene""]",,"The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400256,,,,,,,,"The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200063,,,,,,,,,,,,,,,,5128,CDK17,PCTAIRE2|PCTK2,,,,,,,,,,CDK17 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000096,"[""MET105 in TAOK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000096,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET105 in TAOK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400383,"[""CACNA1C subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400333,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400383,,,,,,,,,,,,,,,,,,,,,,,,,,,,CACNA1C subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200173,"[""KCNIP2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200173,,,,,,,,,,,,,,,,,KCNIP2,,,,,,,,,,,KCNIP2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4531,"[""mucoepidermoid carcinoma""]",,"A salivary gland carcinoma that is characterized by squamous cells, mucus-secreting cells, and intermediate cells.",false,,,http://purl.obolibrary.org/obo/DOID_0050904,,,,,,,,"A salivary gland carcinoma that is characterized by squamous cells, mucus-secreting cells, and intermediate cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4531,,,,NCI:C3772|MESH:D018277|UMLS_CUI:C0206694|SNOMEDCT_US_2016_03_01:4079000,Mucoepidermoid carcinoma (morphologic abnormality)|MEC,,disease_ontology,,DOID:4531,,,,,,,,,,,,,,,,,,,mucoepidermoid carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003849,"[""adenosquamous carcinoma cell""]",,"A type of cancer that contains two types of cells: squamous cells (thin, flat cells that line certain organs) and gland-like cells.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001289,,,,,,,,"A type of cancer that contains two types of cells: squamous cells (thin, flat cells that line certain organs) and gland-like cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003849,,,,,,,BrendaTissueOBO,adenosquamous cell carcinoma cell,BTO:0003849,,,,,,,,,,,,,,,,,,,adenosquamous carcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100756,"[""Pyroglutamylated RFamide peptide receptor""]",,"An orexigenic neuropeptide QRFP receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P65] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"An orexigenic neuropeptide QRFP receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P65] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100756,,,,https://pharos.nih.gov/idg/targets/Q96P65,,,,,,,,,,,,,QRFPR,GPR103,,Q96P65,,,,,,,,Pyroglutamylated RFamide peptide receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300204,"[""NKF3 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300204,,,,,,,,,,,,,,,,,,,,,,,,,,,,NKF3 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000280,"[""cone""]",,A mass of ovule-bearing or pollen-bearing scales or bracts in trees of the pine family or in cycads that are arranged usually on a somewhat elongated axis.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000469,,,,,,,,A mass of ovule-bearing or pollen-bearing scales or bracts in trees of the pine family or in cycads that are arranged usually on a somewhat elongated axis.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000280,,,,,,,BrendaTissueOBO,,BTO:0000280,,,,,,,,,,,,,,,,,,,cone,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200612,"[""OR5A2 gene""]",,"An olfactory receptor 5A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200612,,,,,,,,,,,,,,,,219981,OR5A2,,,,,,,,,,,OR5A2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200614,"[""OR5B3 gene""]",,"An olfactory receptor 5B3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH48] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5B3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH48] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200614,,,,,,,,,,,,,,,,441608,OR5B3,OR5B13,,,,,,,,,,OR5B3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200676,"[""OR7A10 gene""]",,"An olfactory receptor 7A10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76100] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 7A10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76100] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200676,,,,,,,,,,,,,,,,390892,OR7A10,,,,,,,,,,,OR7A10 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100731,"[""Putative P2Y purinoceptor 10""]",,"A P2Y purinoceptor 10 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00398] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300100,,,,,,,,"A P2Y purinoceptor 10 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00398] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100731,,,,https://pharos.nih.gov/idg/targets/O00398,,,,,,,,,,,,,P2RY10,,,O00398,,,,,,,,Putative P2Y purinoceptor 10,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391027,"[""ATP:guanido phosphotransferase family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300324,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391027,,,,,,,,,,,,,,,,,,,,,,,,,,,,ATP:guanido phosphotransferase family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005560,"[""C8-MEF cell""]",,"Mouse embryonic fibroblast cell line oncogenically transformed with both E1A and ras, and containing wild-type p53.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002572,,,,,,,,"Mouse embryonic fibroblast cell line oncogenically transformed with both E1A and ras, and containing wild-type p53.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005560,Marion,2014-02-26T15:50:57Z,,,,,BrendaTissueOBO,C8 cell,BTO:0005560,,,,,,,,,,,,,,,,,,,C8-MEF cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5303,"[""cervical clear cell adenocarcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3702,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5303,,,,UMLS_CUI:C1332912|NCI:C6344,Clear cell carcinoma of the Cervix Uteri,,disease_ontology,,DOID:5303,,,,,,,,,,,,,,,,,,,cervical clear cell adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003929,"[""MM1-R cell""]",,Multiple myeloma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Multiple myeloma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003929,,,,,,,BrendaTissueOBO,MM1.R cell|MM-1R cell|MM.1R cell,BTO:0003929,,,,,,,,,,,,,,,,,,,MM1-R cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400319,"[""TESK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400182,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400319,,,,,,,,,,,,,,,,,,,,,,,,,,,,TESK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004042,"[""subcutaneous adipose tissue""]",,Adipose tissue which is found underneath the skin.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001487,,,,,,,,Adipose tissue which is found underneath the skin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004042,,,,,,,BrendaTissueOBO,subcutaneous fat,BTO:0004042,,,,,,,,,,,,,,,,,,,subcutaneous adipose tissue,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200225,"[""GRM8 gene""]",,"A metabotropic glutamate receptor 8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00222] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400059,,,,,,,,"A metabotropic glutamate receptor 8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00222] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200225,,,,,,,,,,,,,,,,2918,GRM8,GPRC1H|MGLUR8,,,,,,,,,,GRM8 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02302005,"[""5-HT6 receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300017,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02302005,,,,,,,,,,,,,,,,,,,,,,,,,,,,5-HT6 receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9970,"[""obesity""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_654,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9970,,,,ICD10CM:E66.9|SNOMEDCT_US_2016_03_01:154776002|NCI:C3283|SNOMEDCT_US_2016_03_01:190963004|ICD9CM:278.00|UMLS_CUI:C0028754|SNOMEDCT_US_2016_03_01:5476005|MESH:D009765|SNOMEDCT_US_2016_03_01:414916001|EFO:0001073|SNOMEDCT_US_2016_03_01:414915002|OMIM:601665,,,disease_ontology,,DOID:9970,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,obesity,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100139,"[""Adhesion G protein-coupled receptor A3""]",,"A G-protein coupled receptor 125 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IWK6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,"A G-protein coupled receptor 125 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IWK6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100139,,,,https://pharos.nih.gov/idg/targets/Q8IWK6,,,,,,,,,,,,,GPR125,ADGRA3,,Q8IWK6,,,,,,,,Adhesion G protein-coupled receptor A3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200507,"[""STK40 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400229,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200507,,,,,,,,,,,,,,,,83931,STK40,SGK495|SHIK,,,,,,,,,,STK40 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2841,"[""asthma""]",,"A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.",false,,,http://purl.obolibrary.org/obo/DOID_1176,,,,,,,,"A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2841,,,DOID:13830|DOID:5783|DOID:12703|DOID:13829|DOID:2840,EFO:0000270|SNOMEDCT_US_2016_03_01:266398009|SNOMEDCT_US_2016_03_01:155579003|ICD9CM:493|SNOMEDCT_US_2016_03_01:187687003|ICD10CM:J45|KEGG:05310|SNOMEDCT_US_2016_03_01:155574008|ICD9CM:493.9|SNOMEDCT_US_2016_03_01:21341004|OMIM:600807|ICD10CM:J45.90|SNOMEDCT_US_2016_03_01:195979001|SNOMEDCT_US_2016_03_01:278517007|SNOMEDCT_US_2016_03_01:195983001|UMLS_CUI:C0004096|NCI:C28397|SNOMEDCT_US_2016_03_01:195967001|ICD10CM:J45.909|SNOMEDCT_US_2016_03_01:266365004|MESH:D001249,exercise-induced asthma|bronchial hyperreactivity|chronic obstructive asthma with status asthmaticus|chronic obstructive asthma|chronic obstructive asthma with acute exacerbation|Exercise induced asthma,,disease_ontology,,DOID:2841,,,,,,,,,,,,,,,,,Xref MGI.,,asthma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300268,"[""PEK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300151,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300268,,,,,,,,,,,,,,,,,,,,,,,,,,,,PEK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060894,"[""early-onset Parkinson disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_14330,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060894,,,,ORDO:391411,,,,,DOID:0060894,,,,,,,,,,,,,,,,,,,early-onset Parkinson disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391029,"[""Choline/ethanolamine kinase family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300324,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391029,,,,,,,,,,,,,,,,,,,,,,,,,,,,Choline/ethanolamine kinase family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000427,"[""TAOK2 kinase domain""]",,Serine/threonine-protein kinase TAO2; prostate-derived sterile 20-like kinase 1; hKFC-C; KIAA0881; MAP3K17; PSK; PSK1; PSK1-BETA; TAO2; TAOK2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase TAO2; prostate-derived sterile 20-like kinase 1; hKFC-C; KIAA0881; MAP3K17; PSK; PSK1; PSK1-BETA; TAO2; TAOK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000427,,,,,,,,,,,,,,,,,,,200428,,,,,,,,,TAOK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300520,"[""GABRP sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300520,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRP sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200411,"[""OR52B2 gene""]",,"An olfactory receptor 52B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 52B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200411,,,,,,,,,,,,,,,,255725,OR52B2,,,,,,,,,,,OR52B2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100253,"[""Melanocortin receptor 4""]",,"A melanocortin receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32245] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300021,,,,,,,,"A melanocortin receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32245] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100253,,,,https://pharos.nih.gov/idg/targets/P32245,,,,,,,,,,,,,MC4R,,,P32245,,,,,,,,Melanocortin receptor 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1729,"[""retinal vascular occlusion""]",,,false,,,http://purl.obolibrary.org/obo/DOID_341,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1729,,,,SNOMEDCT_US_2016_03_01:193380009|ICD9CM:362.3|SNOMEDCT_US_2016_03_01:267717005|ICD10CM:H34.9|SNOMEDCT_US_2016_03_01:193373007|NCI:C34980|SNOMEDCT_US_2016_03_01:73757007|UMLS_CUI:C0035326|ICD9CM:362.30|SNOMEDCT_US_2016_03_01:155111000|ICD10CM:H34,"Retinal vascular occlusion (disorder)|Unspecified retinal vascular occlusion (disorder)|Retinal vasc. occlusion|Retinal vascular Occlusion|Retinal vascular occlusion, unspecified|Retinal vascular occlusion NOS (disorder)",,disease_ontology,,DOID:1729,,,,,,,,,,,,,,,,,,,retinal vascular occlusion,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000402,"[""S6K1 kinase domain""]",,"Ribosomal protein S6 kinase, 70kDa, polypeptide 1; p70(S6K)-alpha; p70-alpha; p70S6K; p70-S6K; PS6K; RPS6KB1; S6K; S6K1; STK14A",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Ribosomal protein S6 kinase, 70kDa, polypeptide 1; p70(S6K)-alpha; p70-alpha; p70S6K; p70-S6K; PS6K; RPS6KB1; S6K; S6K1; STK14A",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000402,,,,,,,,,,,,,,,,,,,200406,,,,,,,,,S6K1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100011,"[""Neuronal acetylcholine receptor subunit alpha-6""]",,"A neuronal acetylcholine receptor subunit alpha-6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15825] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300495,,,,,,,,"A neuronal acetylcholine receptor subunit alpha-6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15825] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100011,,,,https://pharos.nih.gov/idg/targets/Q15825,,,,,,,,,,,,,CHRNA6,,,Q15825,,,,,,,,Neuronal acetylcholine receptor subunit alpha-6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300004,"[""Class C metabotropic glutamate/pheromone""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300001,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300004,,,,,,,,,,,,,,,,,,,,,,,,,,,,Class C metabotropic glutamate/pheromone,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000184,"[""HIPK1 kinase domain""]",,Homeodomain interacting protein kinase 1; HIPK1; KIAA0630; MGC26642; MGC33446; MGC33548; Myak; Nbak2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Homeodomain interacting protein kinase 1; HIPK1; KIAA0630; MGC26642; MGC33446; MGC33548; Myak; Nbak2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000184,,,,,,,,,,,,,,,,,,,200186,,,,,,,,,HIPK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100022,"[""Muscarinic acetylcholine receptor m2""]",,"A muscarinic acetylcholine receptor M2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08172] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300020,,,,,,,,"A muscarinic acetylcholine receptor M2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08172] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100022,,,,https://pharos.nih.gov/idg/targets/P08172,,,,,,,,,,,,,CHRM2,,,P08172,,,,,,,,Muscarinic acetylcholine receptor m2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000011,"[""CCL13""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000011,,,,,,,,,,,,,,,,,,,,,,,,,,,,CCL13,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12449,"[""aplastic anemia""]",,"An anemia that is characterized by a deficiency of red blood cells, white blood cells and platelets produced by bone marrow.",false,,,http://purl.obolibrary.org/obo/DOID_2355,,,,,,,,"An anemia that is characterized by a deficiency of red blood cells, white blood cells and platelets produced by bone marrow.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12449,,,,MESH:D000741|SNOMEDCT_US_2016_03_01:306058006|SNOMEDCT_US_2016_03_01:154807001|NCI:C2870|ICD10CM:D61.9|SNOMEDCT_US_2016_03_01:191233006|OMIM:609135|ICD9CM:284.9|SNOMEDCT_US_2016_03_01:305047005|SNOMEDCT_US_2016_03_01:267560004|UMLS_CUI:C0002874|SNOMEDCT_US_2016_03_01:191258001|SNOMEDCT_US_2016_03_01:79000000|SNOMEDCT_US_2016_03_01:304132006,,,disease_ontology,,DOID:12449,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,aplastic anemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_16467,"[""L-arginine""]","(S)-2-amino-5-guanidinopentanoic acid|N[C@@H](CCCNC(N)=N)C(O)=O|(S)-2-Amino-5-guanidinovaleric acid|InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1|174.20100|(2S)-2-amino-5-guanidinopentanoic acid|L-(+)-arginine|C6H14N4O2|Arg|arginine|L-Arg|(2S)-2-amino-5-(carbamimidamido)pentanoic acid|L-Arginin|R|0|ODKSFYDXXFIFQN-BYPYZUCNSA-N|174.112",An L-alpha-amino acid that is the L-isomer of arginine.,false,,,http://purl.obolibrary.org/obo/CHEBI_33709,,,,,,,PMID:22243793|PMID:19030957|KEGG:C00062|PMID:22428068|PMID:11300497|PMID:11898853|DrugBank:DB00125|PMID:16416365|Gmelin:83283|PMID:22179117|KNApSAcK:C00001340|Wikipedia:L-arginine|PMID:17439666|PMID:22361732|CAS:74-79-3|ECMDB:ECMDB00517|PMID:15465805|PMID:15016745|PMID:22652429|PMID:11139824|PMID:22667467|PMID:22251130|PMID:21814794|PMID:16056256|PMID:22439203|KEGG:D02982|HMDB:HMDB00517|PMID:22619480|PMID:22553931|PMID:22709481|PMID:22425811|PDBeChem:GND|YMDB:YMDB00592|Beilstein:1725413|PMID:21600268|PMID:17168727|Drug_Central:1549|PDBeChem:ARG|PMID:22626826|PMID:12812828|MetaCyc:ARG|Reaxys:1725413|PMID:8070089|PMID:10848923,An L-alpha-amino acid that is the L-isomer of arginine.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:21235|CHEBI:42927|CHEBI:6185|CHEBI:13077,,L-arginine|L-Arginine,,chebi_ontology,"(S)-2-amino-5-guanidinopentanoic acid|N[C@@H](CCCNC(N)=N)C(O)=O|(S)-2-Amino-5-guanidinovaleric acid|InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1|174.20100|(2S)-2-amino-5-guanidinopentanoic acid|L-(+)-arginine|C6H14N4O2|Arg|arginine|L-Arg|(2S)-2-amino-5-(carbamimidamido)pentanoic acid|L-Arginin|R|0|ODKSFYDXXFIFQN-BYPYZUCNSA-N|174.112",,,CHEBI:16467,,,,,,,,,,,,,,,,,,,,,,,CHEBI:16467,,,,,L-arginine,,CHEBI:16467,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000341,"[""THR315 in ABL1-nonphosphorylated""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000341,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR315 in ABL1-nonphosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003865,"[""enteroendocrine cell""]",,"A group of APUD cells found scattered along the walls of the gastrointestinal tract; their secretions affect motility, secretion of pancreatic enzymes and bile, and growth of the gastrointestinal tract epithelium, and are regulators of other endocrine substances in the intestines.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003866,,,,,,,,"A group of APUD cells found scattered along the walls of the gastrointestinal tract; their secretions affect motility, secretion of pancreatic enzymes and bile, and growth of the gastrointestinal tract epithelium, and are regulators of other endocrine substances in the intestines.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003865,,,,,,,BrendaTissueOBO,basal granular cell,BTO:0003865,,,,,,,,,,,,,,,,,,,enteroendocrine cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000274,"[""PHE691 in FLT3(N841I)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000274,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE691 in FLT3(N841I),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200101,"[""FSHR gene""]",,"A follitropin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P23945] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400042,,,,,,,,"A follitropin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P23945] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200101,,,,,,,,,,,,,,,,2492,FSHR,LGR1,,,,,,,,,,FSHR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200340,"[""MAP2K7 gene""]",,"The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400194,,,,,,,,"The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200340,,,,,,,,,,,,,,,,5609,MAP2K7,JNKK2|MEK7|MKK7,,,,,,,,,,MAP2K7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000218,"[""MET902 in JAK3(JH1domain-catalytic)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000218,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET902 in JAK3(JH1domain-catalytic),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002576,"[""UMR-106 cell""]",,The UMR-106 cell line is a clonal derivative of a transplantable rat osteosarcoma that had been induced by injection of radiophosphorous (32P).,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000407,,,,,,,,The UMR-106 cell line is a clonal derivative of a transplantable rat osteosarcoma that had been induced by injection of radiophosphorous (32P).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002576,,,,,,,BrendaTissueOBO,,BTO:0002576,,,,,,,,,,,,,,,,,,,UMR-106 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10907,"[""microcephaly""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_2490,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10907,,,,ICD9CM:742.1|MESH:D008831|NCI:C85874|SNOMEDCT_US_2016_03_01:204031003|SNOMEDCT_US_2016_03_01:1829003|ICD10CM:Q02|OMIM:612703|OMIM:608716|UMLS_CUI:C0025958|OMIM:251200|OMIM:608393|OMIM:604321|SNOMEDCT_US_2016_03_01:204030002|OMIM:604804|SNOMEDCT_US_2016_03_01:156893009,Microcephalus|microencephaly,,disease_ontology,,DOID:10907,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,microcephaly,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10908,"[""hydrocephalus""]",,"A cerebral degeneration characterized by an abnormal accumulation of cerebrospinal fluid in the ventricles of the brain, leading to progressive enlargement of the head.",false,,,http://purl.obolibrary.org/obo/DOID_1443,,,,,,,,"A cerebral degeneration characterized by an abnormal accumulation of cerebrospinal fluid in the ventricles of the brain, leading to progressive enlargement of the head.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10908,,,,MESH:D006849|ICD10CM:G91|OMIM:236635|OMIM:307000|ORDO:2182|SNOMEDCT_US_2016_03_01:192807008|OMIM:615219|SNOMEDCT_US_2016_03_01:154997008|NCI:C3111|ORDO:2185|OMIM:236600|UMLS_CUI:C0020255|OMIM:123155|SNOMEDCT_US_2016_03_01:154995000|SNOMEDCT_US_2016_03_01:267687006|ICD10CM:G91.9|SNOMEDCT_US_2016_03_01:230745008,"hydrocephalus, nonsyndromic, autosomal recessive|hydrocephalus, X-linked",,disease_ontology,,DOID:10908,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,hydrocephalus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3950,"[""adrenal carcinoma""]",,An adrenal cancer that is located_in the cortex (steroid hormone-producing tissue) of the adrenal gland and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.,false,,,http://purl.obolibrary.org/obo/DOID_3953,,,,,,,,An adrenal cancer that is located_in the cortex (steroid hormone-producing tissue) of the adrenal gland and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3950,,,,UMLS_CUI:C1370740|SNOMEDCT_US_2015_03_01:255035007,carcinoma of the Adrenal gland,,disease_ontology,,DOID:3950,,,,,,,,,,,,,,,,,,,adrenal carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100681,"[""Olfactory receptor 7d4""]",,"An olfactory receptor 7D4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG98] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 7D4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG98] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100681,,,,https://pharos.nih.gov/idg/targets/Q8NG98,,,,,,,,,,,,,OR7D4,OR7D4P,,Q8NG98,,,,,,,,Olfactory receptor 7d4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100660,"[""Olfactory receptor 6J1""]",,"An olfactory receptor 6J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100660,,,,https://pharos.nih.gov/idg/targets/Q8NGC5,,,,,,,,,,,,,OR6J1,OR6J2,,Q8NGC5,,,,,,,,Olfactory receptor 6J1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200257,"[""RPS6KB1 gene""]",,"This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400282,,,,,,,,"This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200257,,,,,,,,,,,,,,,,6198,RPS6KB1,STK14A,,,,,,,,,,RPS6KB1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200100,"[""FAM26F gene""]",,"A protein FAM26F that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5R3K3] ",false,,,http://www.drugtargetontology.org/dto/DTO_01400347,,,,,,,,"A protein FAM26F that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5R3K3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200100,,,,,,,,,,,,,,,,441168,Protein FAM26F|FAM26F,C6orf187,,,,,,,,,,FAM26F gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000059,"[""LEU154 in AURKB""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000059,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU154 in AURKB,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_29997,"[""L-phenylalanine residue""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_33700,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:29997,,,,RESID:AA0014,L-phenylalanine residue,,chebi_ontology,C9H9NO|147.068|L-phenylalanyl|F|147.17390|-Phe-|L-phenylalanine|Phe|0,CHEBI:29997,http://purl.obolibrary.org/obo/chebi#3_STAR,,,,,,,,,,,,,,,,,,L-phenylalanine residue,,,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000082,"[""CDK9 kinase domain""]",,Cyclin-dependent kinase 9; cell division protein kinase 9; C-2k; CDC2L4; CDK9; CTK1; PITALRE; TAK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Cyclin-dependent kinase 9; cell division protein kinase 9; C-2k; CDC2L4; CDK9; CTK1; PITALRE; TAK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000082,,,,,,,,,,,,,,,,,,,200082,,,,,,,,,CDK9 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001398,"[""trypomastigote""]",,"Any of the bodies representing the morphologic (trypanosomal) stage in the life cycle of certain trypanosomatid protozoa, resembling the typical adult form of members of the genus Trypanosoma, in which the slender elongate cell has a kinetoplast and basal body located at the posterior end and a flagellum running anteriorly along an undulating membrane to become a free-flowing structure.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000092,,,,,,,,"Any of the bodies representing the morphologic (trypanosomal) stage in the life cycle of certain trypanosomatid protozoa, resembling the typical adult form of members of the genus Trypanosoma, in which the slender elongate cell has a kinetoplast and basal body located at the posterior end and a flagellum running anteriorly along an undulating membrane to become a free-flowing structure.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001398,,,,,,,BrendaTissueOBO,,BTO:0001398,,,,,,,,,,,,,,,,,,,trypomastigote,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400115,"[""NAK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400115,,,,,,,,,,,,,,,,,,,,,,,,,,,,NAK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100501,"[""Olfactory receptor 1m1""]",,"An olfactory receptor 1M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100501,,,,https://pharos.nih.gov/idg/targets/Q8NGA1,,,,,,,,,,,,,OR1M1,,,Q8NGA1,,,,,,,,Olfactory receptor 1m1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300233,"[""NKF5 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300233,,,,,,,,,,,,,,,,,,,,,,,,,,,,NKF5 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100545,"[""Olfactory receptor 2T1""]",,"An olfactory receptor 2T1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43869] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2T1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43869] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100545,,,,https://pharos.nih.gov/idg/targets/O43869,,,,,,,,,,,,,OR2T1,,,O43869,,,,,,,,Olfactory receptor 2T1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300146,"[""DAPK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300146,,,,,,,,,,,,,,,,,,,,,,,,,,,,DAPK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2021,"[""placenta cancer""]",,,false,,,http://purl.obolibrary.org/obo/DOID_780|http://purl.obolibrary.org/obo/DOID_120,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2021,,,DOID:2023,ICD10CM:C58|SNOMEDCT_US_2016_03_01:188187004|NCI:C3555|SNOMEDCT_US_2016_03_01:449421003|ICD9CM:181|UMLS_CUI:C0153572,Placental tumors|malignant neoplasm of placenta|malignant Placental tumor|primary malignant neoplasm of placenta|neoplasm of placenta (disorder)|placental cancer,,disease_ontology,,DOID:2021,,,,,,,,,,,,,,,,,,,placenta cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001196,"[""SF-21 cell""]",,"Insect - fall armyworm, Spodoptera frugiperda, cell line. This cell line was derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae (species Spodoptera frugiperda, family Sciaridae, order Lepidoptera); cells are susceptible to Baculovirus infection.",false,,,http://purl.obolibrary.org/obo/BTO_0000977|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Insect - fall armyworm, Spodoptera frugiperda, cell line. This cell line was derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae (species Spodoptera frugiperda, family Sciaridae, order Lepidoptera); cells are susceptible to Baculovirus infection.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001196,,,,,,,BrendaTissueOBO,Sf21AE cell|IPLB-SF-21-AE cell|Sf21 cell,BTO:0001196,,,,,,,,,,,,,,,,,,,SF-21 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491033,"[""CDK10 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400136,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491033,,,,,,,,,,,,,,,,,,,,,,,,,,,,CDK10 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000201,"[""MET754 in M3K5""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000201,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET754 in M3K5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100577,"[""L-fucose kinase""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100577,,,,,,,,,,,,,,,,,FUK,,,Q8N0W3,,,,,,,,L-fucose kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400537,"[""Kv1.6/KCNA6 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400436,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400537,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv1.6/KCNA6 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000036,"[""AKT2 kinase domain""]",,V-akt murine thymoma viral oncogene homolog 2; AKT2; Akt2/PKBb; PKBb; PKBBETA; PRKBB; RAC-BETA,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,V-akt murine thymoma viral oncogene homolog 2; AKT2; Akt2/PKBb; PKBb; PKBBETA; PRKBB; RAC-BETA,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000036,,,,,,,,,,,,,,,,,,,200035,,,,,,,,,AKT2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300471,"[""Nav1.5/SCN5A subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300369,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300471,,,,,,,,,,,,,,,,,,,,,,,,,,,,Nav1.5/SCN5A subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000163,"[""MET359 in MYLK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000163,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET359 in MYLK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300241,"[""KIS family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300241,,,,,,,,,,,,,,,,,,,,,,,,,,,,KIS family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200137,"[""ADGRA1 gene""]",,"A G-protein coupled receptor 123 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86SQ6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,"A G-protein coupled receptor 123 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86SQ6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200137,,,,,,,,,,,,,,,,84435,GPR123,KIAA1828,,,,,,,,,,ADGRA1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200180,"[""GPR18 gene""]",,"An N-arachidonyl glycine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14330] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"An N-arachidonyl glycine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14330] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200180,,,,,,,,,,,,,,,,2841,GPR18,GPCRW,,,,,,,,,,GPR18 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200182,"[""KCNA3 gene""]",,"Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400534,,,,,,,,"Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200182,,,,,,,,,,,,,,,,3738,KCNA3,HGK5,,,,,,,,,,KCNA3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491027,"[""ATP:guanido phosphotransferase family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400324,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491027,,,,,,,,,,,,,,,,,,,,,,,,,,,,ATP:guanido phosphotransferase family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100158,"[""Cyclin-g-associated kinase""]",,"A cyclin-G-associated kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14976] |cyclin-g-associated kinase (GAK)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300115,,,,,,,,"A cyclin-G-associated kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14976] |cyclin-g-associated kinase (GAK)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100158,,,,https://pharos.nih.gov/idg/targets/O14976,,,,,,,,,,,,,GAK,,,O14976,,,,,,,,Cyclin-g-associated kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_809,"[""cocaine abuse""]",,A substance abuse that involves the recurring use of cocaine despite negative consequences.,false,,,http://purl.obolibrary.org/obo/DOID_302,,,,,,,,A substance abuse that involves the recurring use of cocaine despite negative consequences.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:809,,,,ICD10CM:F14.1|ICD9CM:305.60|MESH:D019970|SNOMEDCT_US_2016_03_01:78267003|ICD9CM:305.6|UMLS_CUI:C0009171,,,disease_ontology,,DOID:809,,,,,,,,,,,,,,,,,,,cocaine abuse,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000781,"[""intestinal epithelium""]",,"The endodermally-derived epithelium of the intestine varies considerably, but the absorptive epithelium of small intestine is usually implied.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000416,,,,,,,,"The endodermally-derived epithelium of the intestine varies considerably, but the absorptive epithelium of small intestine is usually implied.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000781,,,,,,,BrendaTissueOBO,,BTO:0000781,,,,,,,,,,,,,,,,,,,intestinal epithelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100662,"[""Olfactory receptor 6K3""]",,"An olfactory receptor 6K3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6K3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100662,,,,https://pharos.nih.gov/idg/targets/Q8NGY3,,,,,,,,,,,,,OR6K3,,,Q8NGY3,,,,,,,,Olfactory receptor 6K3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100322,"[""Olfactory receptor 10S1""]",,"An olfactory receptor 10S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100322,,,,https://pharos.nih.gov/idg/targets/Q8NGN2,,,,,,,,,,,,,OR10S1,,,Q8NGN2,,,,,,,,Olfactory receptor 10S1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200684,"[""OR7G3 gene""]",,"An olfactory receptor 7G3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG95] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 7G3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG95] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200684,,,,,,,,,,,,,,,,390883,OR7G3,,,,,,,,,,,OR7G3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001395,"[""trichome""]",,A filamentous outgrowth; especially: an epidermal hair structure on a plant.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A filamentous outgrowth; especially: an epidermal hair structure on a plant.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001395,,,,,,,BrendaTissueOBO,,BTO:0001395,,,,,,,,,,,,,,,,,,,trichome,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117465,"[""Liver x receptor-like receptors""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00102000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117465,,,,,,,,,,,,,,,,,,,,,,,,,,,,Liver x receptor-like receptors,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002747,"[""PC-1 cell""]",,Hamster pancreatic cancer cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001521,,,,,,,,Hamster pancreatic cancer cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002747,,,,,,,BrendaTissueOBO,,BTO:0002747,,,,,,,,,,,,,,,,,,,PC-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3571,"[""liver cancer""]",,A gastrointestinal system cancer that is located_in the liver.,false,,,http://purl.obolibrary.org/obo/DOID_170|http://purl.obolibrary.org/obo/DOID_409|http://purl.obolibrary.org/obo/DOID_3119,,,,,,,,A gastrointestinal system cancer that is located_in the liver.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3571,,,DOID:12300|DOID:915|DOID:269|DOID:7330|DOID:919,ICD9CM:155.0|UMLS_CUI:C0024620|SNOMEDCT_US_2016_03_01:154470007|SNOMEDCT_US_2016_03_01:269548006|NCI:C34803|SNOMEDCT_US_2016_03_01:93870000|NCI:C7692|ICD10CM:C22.9|MESH:D008113|UMLS_CUI:C0023903|SNOMEDCT_US_2016_03_01:187779006|SNOMEDCT_US_2016_03_01:187768001|SNOMEDCT_US_2016_03_01:95214007|ICD9CM:155.2|ICD10CM:C22.0|SNOMEDCT_US_2016_03_01:126851005|UMLS_CUI:C0854795|UMLS_CUI:C0345904|SNOMEDCT_US_2016_03_01:363361004|SNOMEDCT_US_2016_03_01:187771009,"primary malignant neoplasm of liver|malignant hepato-biliary neoplasm|malignant tumor of liver (disorder)|resectable malignant neoplasm of the liver|hepatic neoplasm|primary malignant neoplasm of liver (disorder)|Resectable malignant neoplasm of Liver|primary malignant neoplasm of Liver|malignant neoplasm of liver, not specified as primary or secondary|malignant neoplasm of liver unspecified (disorder)|malignant neoplasm of liver, primary|primary liver cancer|malignant neoplasm of liver|primary malignant neoplasm of liver NOS (disorder)|ca liver - primary|hepatic cancer|Ca liver - primary (disorder)|neoplasm of liver (disorder)|malignant neoplasm of liver (disorder)|non-resectable primary hepatic malignant neoplasm",,disease_ontology,,DOID:3571,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,liver cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005445,"[""rectal epithelium""]",,Epithelium of the rectum.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Epithelium of the rectum.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005445,XPMUser,2013-04-26T10:08:43Z,,,,,BrendaTissueOBO,rectum epithelium,BTO:0005445,,,,,,,,,,,,,,,,,,,rectal epithelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100207,"[""G-protein coupled receptor 6""]",,"A G-protein coupled receptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46095] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46095] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100207,,,,https://pharos.nih.gov/idg/targets/P46095,,,,,,,,,,,,,GPR6,,,P46095,,,,,,,,G-protein coupled receptor 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000434,"[""TIE1 kinase domain""]",,Tyrosine-protein kinase receptor Tie-1; tyrosine kinase with immunoglobulin-like and EGF-like domains 1; JTK14; TIE; TIE1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Tyrosine-protein kinase receptor Tie-1; tyrosine kinase with immunoglobulin-like and EGF-like domains 1; JTK14; TIE; TIE1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000434,,,,,,,,,,,,,,,,,,,200435,,,,,,,,,TIE1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000019,"[""ABL1(Q252H)-phosphorylated kinase domain""]",,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",false,,,http://www.drugtargetontology.org/dto/DTO_61000017,,,,,,,,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000019,,,,,,,,,,,,,,,,,,,200018,,,,,,,,,ABL1(Q252H)-phosphorylated kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050194,"[""Argentine hemorrhagic fever""]",,"A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Junin virus, which is transmitted_by rodent, Calomys musculinus. The infection has_symptom fever, has_symptom fatigue, has_symptom malaise, has_symptom leukopenia, has_symptom thrombocytopenia, and has_symptom hemorrhagic manifestations.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Junin virus, which is transmitted_by rodent, Calomys musculinus. The infection has_symptom fever, has_symptom fatigue, has_symptom malaise, has_symptom leukopenia, has_symptom thrombocytopenia, and has_symptom hemorrhagic manifestations.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050194,,,,,,,disease_ontology,,DOID:0050194,http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,Argentine hemorrhagic fever,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300475,"[""Nav1.8/SCN10A subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300369,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300475,,,,,,,,,,,,,,,,,,,,,,,,,,,,Nav1.8/SCN10A subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200170,"[""GSG2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400161,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200170,,,,,,,,,,,,,,,,83903,GSG2,,,,,,,,,,,GSG2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005155,"[""CEM-VBL100 cell""]",,The CEM-VBL100 cell line is a multidrug-resistant variant of the derivative of the CCRF-CEM cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000225,,,,,,,,The CEM-VBL100 cell line is a multidrug-resistant variant of the derivative of the CCRF-CEM cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005155,XPMUser,2011-08-27T03:22:14Z,,,,,BrendaTissueOBO,CEM-VLB100 cell|CEM/VLB100 cell|CEM/VLB 100,BTO:0005155,,,,,,,,,,,,,,,,,,,CEM-VBL100 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003428,"[""beta-TC6 cell""]",,Mouse insulinoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000794,,,,,,,,Mouse insulinoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003428,,,,,,,BrendaTissueOBO,beta TC6 cell,BTO:0003428,,,,,,,,,,,,,,,,,,,beta-TC6 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200290,"[""MAP3K8 gene""]",,"This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400185,,,,,,,,"This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200290,,,,,,,,,,,,,,,,1326,MAP3K8,COT|ESTF,,,,,,,,,,MAP3K8 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100070,"[""Cyclin-dependent kinase 4""]",,"cyclin-dependent kinase 4 (CDK4-cyclinD3)  with  no mutation  in a nonphosphorylated state|A cell division protein kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11802] |cyclin-dependent kinase 4 (CDK4-cyclinD1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300260,,,,,,,,"cyclin-dependent kinase 4 (CDK4-cyclinD3)  with  no mutation  in a nonphosphorylated state|A cell division protein kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11802] |cyclin-dependent kinase 4 (CDK4-cyclinD1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100070,,,,https://pharos.nih.gov/idg/targets/P11802,,,,,,,,,,,,,CDK4,,,P11802,,,,,,,,Cyclin-dependent kinase 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_9574,"[""Thrombin""]",Thrombin,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG COMPOUND:9002-04-4|KEGG COMPOUND:C00752|KEGG DRUG:D00090,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,Thrombin,,chebi_ontology,,,,CHEBI:9574,,,,,,,,,,,,,,,,,,,,,,,CHEBI:9574,,,,,Thrombin,,CHEBI:9574,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3527,"[""cerebral arterial disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_13089,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3527,,,,UMLS_CUI:C0007774|MESH:D002539,,,disease_ontology,,DOID:3527,,,,,,,,,,,,,,,,,,,cerebral arterial disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300101,"[""Kinase""]",,"In biochemistry, a kinase is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates.",false,,,http://purl.obolibrary.org/obo/PR_000000001,,,,,,,,"In biochemistry, a kinase is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300101,,,,,,,,,,,,,,,,,,,,,,,,,,,https://en.wikipedia.org/wiki/Kinase,Kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100396,"[""Olfactory receptor 51g1""]",,"An olfactory receptor 51G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 51G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100396,,,,https://pharos.nih.gov/idg/targets/Q8NGK1,,,,,,,,,,,,,OR51G1,OR51G3P,,Q8NGK1,,,,,,,,Olfactory receptor 51g1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000238,"[""LOK kinase domain""]",,Serine/threonine-protein kinase 10,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase 10,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000238,,,,,,,,,,,,,,,,,,,200228,,,,,,,,,LOK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217569,"[""PGR gene""]",,"This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Jan 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_00217474,,,,,,,,"This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Jan 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217569,,,,,,,,,,,,,,,,5241,PGR,NR3C3,,,,,,,,,,PGR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001297,"[""sputum""]",,"Matter ejected from the lungs, bronchi, and trachea, through the mouth.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Matter ejected from the lungs, bronchi, and trachea, through the mouth.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001297,,,,,,,BrendaTissueOBO,expectoration,BTO:0001297,,,,,,,,,,,,,,,,,,,sputum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400589,"[""TRPM8 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400483,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400589,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPM8 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200535,"[""OR2L3 gene""]",,"An olfactory receptor 2L3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG85] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2L3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG85] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200535,,,,,,,,,,,,,,,,391192,OR2L3,,,,,,,,,,,OR2L3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100259,"[""Ribosomal protein s6 kinase delta-1""]",,"A ribosomal protein S6 kinase delta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96S38] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300179,,,,,,,,"A ribosomal protein S6 kinase delta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96S38] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100259,,,,https://pharos.nih.gov/idg/targets/Q96S38,,,,,,,,,,,,,RPS6KC1,RPK118,,Q96S38,,,,,,,,Ribosomal protein s6 kinase delta-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1003,"[""pelvic inflammatory disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_229,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1003,,,,ICD10CM:N70-N77|ICD10CM:N73.9|SNOMEDCT_US_2016_03_01:266648001|SNOMEDCT_US_2016_03_01:198570007|SNOMEDCT_US_2016_03_01:198244005|SNOMEDCT_US_2016_03_01:266651008|UMLS_CUI:C0242172|SNOMEDCT_US_2016_03_01:155968004|ICD9CM:614.9|SNOMEDCT_US_2016_03_01:198178006|SNOMEDCT_US_2016_03_01:37518008|SNOMEDCT_US_2016_03_01:266584000|SNOMEDCT_US_2016_03_01:198130006|ICD9CM:614-616.99|SNOMEDCT_US_2016_03_01:198131005|SNOMEDCT_US_2016_03_01:155974004|SNOMEDCT_US_2016_03_01:155967009|SNOMEDCT_US_2016_03_01:155986001|MESH:D000292|NCI:C3889,PID,,disease_ontology,,DOID:1003,,,,,,,,,,,,,,,,,,,pelvic inflammatory disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10034,"[""eye accommodation disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5614,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10034,,,,SNOMEDCT_US_2016_03_01:54552008|UMLS_CUI:C0152198|SNOMEDCT_US_2016_03_01:193631008|ICD10CM:H52.5|ICD9CM:367.5|SNOMEDCT_US_2016_03_01:155137002,,,disease_ontology,,DOID:10034,,,,,,,,,,,,,,,,,,,eye accommodation disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10033,"[""cycloplegia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_10034,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10033,,,,SNOMEDCT_US_2016_03_01:232141000|UMLS_CUI:C0235238|ICD10CM:H52.52|SNOMEDCT_US_2016_03_01:68158006|ICD9CM:367.51|SNOMEDCT_US_2016_03_01:255335004,Paresis of accommodation|Cycloplegic paralysis of accommodation|Ciliary muscle paresis,,disease_ontology,,DOID:10033,,,,,,,,,,,,,,,,,,,cycloplegia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000862,"[""heart ventricle""]",,A chamber of the heart which receives blood from a corresponding atrium and from which blood is forced into the arteries.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A chamber of the heart which receives blood from a corresponding atrium and from which blood is forced into the arteries.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000862,,,,,,,BrendaTissueOBO,cardiac ventricle,BTO:0000862,,,,,,,,,,,,,,,,,,,heart ventricle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117517,"[""Glucocorticoid receptor""]",,"A glucocorticoid receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P04150] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117474,,,,,,,,"A glucocorticoid receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P04150] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117517,,,,https://pharos.nih.gov/idg/targets/P04150,,,,,,,,,,,,,NR3C1,,,P04150,,,,,,,,Glucocorticoid receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001293,"[""sporulated oocyst""]",,A sporozoan zygote undergoing sporogenous development.,false,,,http://purl.obolibrary.org/obo/BTO_0001773|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A sporozoan zygote undergoing sporogenous development.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001293,,,,,,,BrendaTissueOBO,,BTO:0001293,,,,,,,,,,,,,,,,,,,sporulated oocyst,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000024,"[""ILE917 in TIE1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30009,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000024,,,,,,,,,,,,,,,,,,,,,,,,,,,,ILE917 in TIE1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200227,"[""HCAR1 gene""]",,"A hydroxycarboxylic acid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BXC0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400060,,,,,,,,"A hydroxycarboxylic acid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BXC0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200227,,,,,,,,,,,,,,,,27198,HCAR1,GPR104|GPR81|HCA1,,,,,,,,,,HCAR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002768,"[""mammary epithelial cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000816,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002768,,,,,,,BrendaTissueOBO,,BTO:0002768,,,,,,,,,,,,,,,,,,,mammary epithelial cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12028,"[""Conn's syndrome""]",,An adrenal admenoma characterized by over production of aldosterone.,false,,,http://purl.obolibrary.org/obo/DOID_656,,,,,,,,An adrenal admenoma characterized by over production of aldosterone.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12028,,,,SNOMEDCT_US_2016_03_01:267484005|SNOMEDCT_US_2016_03_01:154709005|SNOMEDCT_US_2016_03_01:190506003|NCI:C34510|ICD10CM:E26.0|ICD9CM:255.12|UMLS_CUI:C1384514|SNOMEDCT_US_2016_03_01:258117004|ICD10CM:E26.01|MESH:D006929|SNOMEDCT_US_2016_03_01:13536004|SNOMEDCT_US_2016_03_01:190507007,Conn syndrome|primary hyperaldosteronism|primary aldosteronism,,disease_ontology,,DOID:12028,,,,,,,,,,,,,,,,,,,Conn's syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_396,"[""Loeffler endocarditis""]",,"A restrictive cardiomyopathy that affects the endocardium and occurs with white blood cell proliferation, specifically of eosinophils.",false,,,http://purl.obolibrary.org/obo/DOID_397,,,,,,,,"A restrictive cardiomyopathy that affects the endocardium and occurs with white blood cell proliferation, specifically of eosinophils.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:396,,,,ICD10CM:I42.3|SNOMEDCT_US_2016_03_01:33258008|UMLS_CUI:C0264834|NCI:C27044,Eosinophilic Endomyocardial disease,,disease_ontology,,DOID:396,,,,,,,,,,,,,,,,,,,Loeffler endocarditis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_399,"[""tuberculosis""]",,"A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes.",false,,,http://purl.obolibrary.org/obo/DOID_0050338,,,,,,,,"A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:399,,,DOID:12691|DOID:415|DOID:9901|DOID:9902|DOID:12688|DOID:10096,MESH:D014376|MESH:D014375|UMLS_CUI:C0041295|SNOMEDCT_US_2016_03_01:15202009,,,disease_ontology,,DOID:399,http://purl.obolibrary.org/obo/doid#gram-positive_bacterial_infectious_disease,,,,,,,,,,,,,,,,,,tuberculosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_397,"[""restrictive cardiomyopathy""]",,"Xref MGI.
OMIM mappings 115210, 612422 added from NeuroDevNet [WAK].",false,,,http://purl.obolibrary.org/obo/DOID_0060036,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:397,,,,SNOMEDCT_US_2016_03_01:415295002|UMLS_CUI:C0007196|SNOMEDCT_US_2016_03_01:90828009|OMIM:612422|MESH:D002313|NCI:C62798|OMIM:615248|ICD10CM:I42.5|OMIM:609578|ORDO:75249|OMIM:115210|SNOMEDCT_US_2016_03_01:389996009,"Restrictive cardiomyopathy|Cardiomyopathy, constrictive|Restrictive cardiomyopathy (disorder)|primary restrictive cardiomyopathy (disorder)",,disease_ontology,Familial restrictive cardiomyopathy,DOID:397,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mappings 115210, 612422 added from NeuroDevNet [WAK].",,restrictive cardiomyopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000258,"[""choroid plexus""]",,The choroid plexus is tissue located in the spaces inside the brain called ventricles. The choroid plexus makes the fluid that fills the ventricles and surrounds the brain and spinal cord.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The choroid plexus is tissue located in the spaces inside the brain called ventricles. The choroid plexus makes the fluid that fills the ventricles and surrounds the brain and spinal cord.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000258,,,,,,,BrendaTissueOBO,,BTO:0000258,,,,,,,,,,,,,,,,,,,choroid plexus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1436,"[""corneal ectasia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_10124,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1436,,,,SNOMEDCT_US_2016_03_01:14748007|UMLS_CUI:C0155135|ICD10CM:H18.71|ICD9CM:371.71,,,disease_ontology,,DOID:1436,,,,,,,,,,,,,,,,,,,corneal ectasia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000740,"[""myeloid leukemia cell line""]",,"A cell line of leukemia characterized by proliferation of myeloid tissue (as of the bone marrow and spleen) and an abnormal increase in the number of granulocytes, myelocytes, and myeloblasts in the circulating blood.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000737,,,,,,,,"A cell line of leukemia characterized by proliferation of myeloid tissue (as of the bone marrow and spleen) and an abnormal increase in the number of granulocytes, myelocytes, and myeloblasts in the circulating blood.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000740,,,,,,,BrendaTissueOBO,myelogenous leukemia cell line|granulocytic leukemia cell line|myelocytic leukemia cell line,BTO:0000740,,,,,,,,,,,,,,,,,,,myeloid leukemia cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100213,"[""Probable g-protein coupled receptor 85""]",,"A G-protein coupled receptor 85 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P60893] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 85 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P60893] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100213,,,,https://pharos.nih.gov/idg/targets/P60893,,,,,,,,,,,,,GPR85,SREB2,,P60893,,,,,,,,Probable g-protein coupled receptor 85,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400260,"[""CDK4 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400136,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400260,,,,,,,,,,,,,,,,,,,,,,,,,,,,CDK4 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8929,"[""atrophic gastritis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4029,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8929,,,DOID:9083|DOID:9048,ICD9CM:535.11|SNOMEDCT_US_2016_03_01:84568007|SNOMEDCT_US_2016_03_01:155713006|ICD10CM:K29.4|UMLS_CUI:C0156073|SNOMEDCT_US_2016_03_01:270533009|MESH:D005757|ICD9CM:535.1|NCI:C7405|UMLS_CUI:C0017154|SNOMEDCT_US_2016_03_01:196733008,gastric atrophy,,disease_ontology,,DOID:8929,,,,,,,,,,,,,,,,,,,atrophic gastritis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100707,"[""Olfactory receptor 8s1""]",,"An olfactory receptor 8S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH09] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 8S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH09] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100707,,,,https://pharos.nih.gov/idg/targets/Q8NH09,,,,,,,,,,,,,OR8S1,,,Q8NH09,,,,,,,,Olfactory receptor 8s1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300377,"[""Acid-sensing ion channel 2 (ASIC2) subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300330,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300377,,,,,,,,,,,,,,,,,,,,,,,,,,,,Acid-sensing ion channel 2 (ASIC2) subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100628,"[""Xylulose kinase""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100628,,,,,,,,,,,,,,,,,XYLB,,,O75191,,,,,,,,Xylulose kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200635,"[""OR5L2 gene""]",,"An olfactory receptor 5L2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5L2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200635,,,,,,,,,,,,,,,,26338,OR5L2,,,,,,,,,,,OR5L2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4953,"[""poliomyelitis""]",,"A viral infectious disease that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, has_symptom muscle spasms, and has_symptom acute flaccid paralysis.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, has_symptom muscle spasms, and has_symptom acute flaccid paralysis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4953,,,,UMLS_CUI:C0032371|SNOMEDCT_US_2016_03_01:186481004|MESH:D011051|ICD10CM:A80.9|ICD9CM:045|SNOMEDCT_US_2016_03_01:54839009|ICD9CM:045.9|SNOMEDCT_US_2016_03_01:398102009|SNOMEDCT_US_2016_03_01:398256009|SNOMEDCT_US_2016_03_01:367318001|SNOMEDCT_US_2016_03_01:266189002|SNOMEDCT_US_2016_03_01:186475007|ICD10CM:A80|NCI:C35550|SNOMEDCT_US_2016_03_01:154320008|SNOMEDCT_US_2016_03_01:187390004,,,disease_ontology,,DOID:4953,,,,,,,,,,,,,,,,,,,poliomyelitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/UBERON_0001062,"[""anatomical entity""]",,Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species.,false,,,http://www.w3.org/2002/07/owl#Thing,,,,,,,http://linkedlifedata.com/resource/umls/id/C1515976|TGMA:0001822|CARO:0000000|MA:0000001|NIF_GrossAnatomy:birnlex_6|HAO:0000000|BILA:0000000|FBbt:10000000|AAO:0010841|FMA:62955|AEO:0000000|FBbt_root:00000000|TAO:0100000|ZFA:0100000|EHDAA2:0002229|ncithesaurus:Anatomic_Structure_System_or_Substance|UMLS:C1515976,Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,uberon,,,,,,,,,,,,,,,,,,,,,,,,,,,UBERON:0001062,,,,,anatomical entity,,UBERON:0001062,,http://purl.obolibrary.org/obo/uberon.owl,http://purl.obolibrary.org/obo/uberon/core#upper_level,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100271,"[""Pannexin-1""]",,"A pannexin-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD7] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300365,,,,,,,,"A pannexin-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100271,,,,https://pharos.nih.gov/idg/targets/Q96RD7,,,,,,,,,,,,,PANX1,MRS1,,Q96RD7,,,,,,,,Pannexin-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002295,"[""podocyte""]",,"A modified epithelial cell of the capsular epithelium of the renal glomerulus, having a small perikaryon and a number of primary and secondary footlike radiating processes (pedicels) that interdigitate with those of other podocytes and embrace the basal lamina of glomerular capillaries.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000414,,,,,,,,"A modified epithelial cell of the capsular epithelium of the renal glomerulus, having a small perikaryon and a number of primary and secondary footlike radiating processes (pedicels) that interdigitate with those of other podocytes and embrace the basal lamina of glomerular capillaries.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002295,,,,,,,BrendaTissueOBO,renal glomerular podocyte,BTO:0002295,,,,,,,,,,,,,,,,,,,podocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001666,"[""hepatoblastoma cell""]",,A malignant intrahepatic tumor occurring in infants and young children and consisting chiefly of embryonic hepatic tissue.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000608,,,,,,,,A malignant intrahepatic tumor occurring in infants and young children and consisting chiefly of embryonic hepatic tissue.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001666,,,,,,,BrendaTissueOBO,,BTO:0001666,,,,,,,,,,,,,,,,,,,hepatoblastoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001584,"[""G-361 cell""]",,Homo sapiens (human); skin; malignant melanoma cell line; established from a 31 year old caucasian male.,false,,,http://purl.obolibrary.org/obo/BTO_0000849|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Homo sapiens (human); skin; malignant melanoma cell line; established from a 31 year old caucasian male.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001584,,,,,,,BrendaTissueOBO,,BTO:0001584,,,,,,,,,,,,,,,,,,,G-361 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200031,"[""BEST2 gene""]",,"This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The bestrophin 2 gene is mainly expressed in the retinal pigment epithelium and colon. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400331,,,,,,,,"This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The bestrophin 2 gene is mainly expressed in the retinal pigment epithelium and colon. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200031,,,,,,,,,,,,,,,,54831,BEST2,VMD2L1,,,,,,,,,,BEST2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100738,"[""Proteinase-activated receptor 2""]",,"A proteinase-activated receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P55085] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300079,,,,,,,,"A proteinase-activated receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P55085] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100738,,,,https://pharos.nih.gov/idg/targets/P55085,,,,,,,,,,,,,F2RL1,GPR11|PAR2,,P55085,,,,,,,,Proteinase-activated receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4447,"[""cystoid macular edema""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_4449,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4447,,,,MESH:D008269|SNOMEDCT_US_2016_03_01:193387007|UMLS_CUI:C0024440|OMIM:153880|NCI:C34794,,,disease_ontology,,DOID:4447,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,cystoid macular edema,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000306,"[""MYO3B kinase domain""]",,Myosin IIIB; MYO3B,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Myosin IIIB; MYO3B,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000306,,,,,,,,,,,,,,,,,,,200283,,,,,,,,,MYO3B kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200083,"[""CLIC5 gene""]",,"This gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The encoded protein associates with actin-based cytoskeletal structures and may play a role in multiple processes including hair cell stereocilia formation, myoblast proliferation and glomerular podocyte and endothelial cell maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400342,,,,,,,,"This gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The encoded protein associates with actin-based cytoskeletal structures and may play a role in multiple processes including hair cell stereocilia formation, myoblast proliferation and glomerular podocyte and endothelial cell maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200083,,,,,,,,,,,,,,,,53405,CLIC5,,,,,,,,,,,CLIC5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100546,"[""Tau-tubulin kinase 2""]",,"A tau-tubulin kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IQ55] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300239,,,,,,,,"A tau-tubulin kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IQ55] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100546,,,,https://pharos.nih.gov/idg/targets/Q6IQ55,,,,,,,,,,,,,TTBK2,KIAA0847,,Q6IQ55,,,,,,,,Tau-tubulin kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200698,"[""OR8H2 gene""]",,"An olfactory receptor 8H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N162] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 8H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N162] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200698,,,,,,,,,,,,,,,,390151,OR8H2,,,,,,,,,,,OR8H2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400533,"[""Kv1.2/KCNA2 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400436,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400533,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv1.2/KCNA2 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200045,"[""BMPR1B gene""]",,"This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400246,,,,,,,,"This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200045,,,,,,,,,,,,,,,,658,BMPR1B,,,,,,,,,,,BMPR1B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100059,"[""Cyclin-dependent kinase 13""]",,"cyclin-dependent kinase 13 (CDC2L5)  with  no mutation  in a nonphosphorylated state|A cyclin-dependent kinase 13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14004] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300255,,,,,,,,"cyclin-dependent kinase 13 (CDC2L5)  with  no mutation  in a nonphosphorylated state|A cyclin-dependent kinase 13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14004] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100059,,,,https://pharos.nih.gov/idg/targets/Q14004,,,,,,,,,,,,,CDK13,CDC2L|CDC2L5|CHED|KIAA1791,,Q14004,,,,,,,,Cyclin-dependent kinase 13,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1928,"[""Williams-Beuren syndrome""]",,OMIM mapping confirmed by DO. [LS].,false,,,http://purl.obolibrary.org/obo/DOID_0060388,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1928,,,,OMIM:194050|MESH:D018980|UMLS_CUI:C0175702|SNOMEDCT_US_2016_03_01:63247009|NCI:C85232,Fanconi Schlesinger syndrome,,disease_ontology,,DOID:1928,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,Williams-Beuren syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200459,"[""OR6C70 gene""]",,"An olfactory receptor 6C70 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NIJ9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6C70 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NIJ9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200459,,,,,,,,,,,,,,,,390327,OR6C70,,,,,,,,,,,OR6C70 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100105,"[""Fxyd domain-containing ion transport regulator 7""]",,"An FXYD domain-containing ion transport regulator 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58549] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300348,,,,,,,,"An FXYD domain-containing ion transport regulator 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58549] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100105,,,,https://pharos.nih.gov/idg/targets/P58549,,,,,,,,,,,,,FXYD7,,,P58549,,,,,,,,Fxyd domain-containing ion transport regulator 7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100674,"[""Putative olfactory receptor 7a2""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100674,,,,https://pharos.nih.gov/idg/targets/Q8NGA2,,,,,,,,,,,,,OR7A2P,OR7A2|OR7A7,,Q8NGA2,,,,,,,,Putative olfactory receptor 7a2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300388,"[""CACNA1H subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300333,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300388,,,,,,,,,,,,,,,,,,,,,,,,,,,,CACNA1H subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100519,"[""Tyrosine-protein kinase tec""]",,"tyrosine-protein kinase tec (TEC)  with  no mutation  in a nonphosphorylated state|A tyrosine-protein kinase Tec that is encoded in the genome of human. [PRO:WCB, UniProtKB:P42680] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300133,,,,,,,,"tyrosine-protein kinase tec (TEC)  with  no mutation  in a nonphosphorylated state|A tyrosine-protein kinase Tec that is encoded in the genome of human. [PRO:WCB, UniProtKB:P42680] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100519,,,,https://pharos.nih.gov/idg/targets/P42680,,,,,,,,,,,,,TEC,PSCTK4,,P42680,,,,,,,,Tyrosine-protein kinase tec,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1519,"[""cecum carcinoma""]",,A cecum cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.,false,,,http://purl.obolibrary.org/obo/DOID_305|http://purl.obolibrary.org/obo/DOID_1521,,,,,,,,A cecum cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1519,,,,SNOMEDCT_US_2016_03_01:187756005|NCI:C3491|UMLS_CUI:C0149640|SNOMEDCT_US_2016_03_01:255081007|SNOMEDCT_US_2016_03_01:154459000|SNOMEDCT_US_2016_03_01:269538009,Caecum carcinoma|Cecal cancer|carcinoma of cecum,,disease_ontology,,DOID:1519,,,,,,,,,,,,,,,,,,,cecum carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200305,"[""MARK4 gene""]",,"This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400290,,,,,,,,"This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200305,,,,,,,,,,,,,,,,57787,MARK4,KIAA1860|MARKL1,,,,,,,,,,MARK4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_65,"[""connective tissue disease""]",,"A musculoskeletal system disease that affects tissues such as skin, tendons, and cartilage.",false,,,http://purl.obolibrary.org/obo/DOID_17,,,,,,,,"A musculoskeletal system disease that affects tissues such as skin, tendons, and cartilage.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:65,,,,SNOMEDCT_US_2016_03_01:268048008|SNOMEDCT_US_2016_03_01:105969002|NCI:C26729|SNOMEDCT_US_2016_03_01:268126004|UMLS_CUI:C0009782|MESH:D003240|SNOMEDCT_US_2016_03_01:201432001,connective tissue disorder|disorder of connective tissue,,disease_ontology,,DOID:65,,,,,,,,,,,,,,,,,,,connective tissue disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_655,"[""inherited metabolic disorder""]",,A disease of metabolism that has _material_basis_in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to inherited enzyme abnormality.,false,,,http://purl.obolibrary.org/obo/DOID_0014667,,,,,,,,A disease of metabolism that has _material_basis_in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to inherited enzyme abnormality.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:655,,,,SNOMEDCT_US_2016_03_01:86095007|UMLS_CUI:C0025521|SNOMEDCT_US_2016_03_01:363205007|MESH:D008661|NCI:C34816,Inborn Errors of Metabolism|inborn metabolism disorder|Metabolic hereditary disorder,,disease_ontology,,DOID:655,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,inherited metabolic disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_656,"[""adrenal adenoma""]",,An endocrine organ benign neoplasm that is a benign tumor of the glandular type (adenoma) in the adrenal gland.,false,,,http://purl.obolibrary.org/obo/DOID_0060089,,,,,,,,An endocrine organ benign neoplasm that is a benign tumor of the glandular type (adenoma) in the adrenal gland.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:656,,,,,adenoma of the Adrenal gland,,disease_ontology,,DOID:656,,,,,,,,,,,,,,,,,,,adrenal adenoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_653,"[""purine-pyrimidine metabolic disorder""]",,An inherited metabolic disorder involving dysfunction of purine and pyrimidine metabolism.,false,,,http://purl.obolibrary.org/obo/DOID_655,,,,,,,,An inherited metabolic disorder involving dysfunction of purine and pyrimidine metabolism.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:653,,,,SNOMEDCT_US_2016_03_01:190922005|SNOMEDCT_US_2016_03_01:191109006|ICD9CM:277.2|ICD10CM:E79.8|SNOMEDCT_US_2016_03_01:267450006|UMLS_CUI:C0029595|SNOMEDCT_US_2016_03_01:190917005,inborn errors of purine-pyrimidine metabolism,,disease_ontology,,DOID:653,,,,,,,,,,,,,,,,,,,purine-pyrimidine metabolic disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_654,"[""overnutrition""]",,Updated outdated UMLS CUI.,false,,,http://purl.obolibrary.org/obo/DOID_374,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:654,,,,UMLS_CUI:C1257763|MESH:D044343|SNOMEDCT_US_2016_03_01:302872003,,,disease_ontology,,DOID:654,,,,,,,,,,,,,,,,,Updated outdated UMLS CUI.,,overnutrition,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_657,"[""adenoma""]",,A cell type benign neoplasm that is composed_of epithelial tissue in which tumor cells form glands or glandlike structures.,false,,,http://purl.obolibrary.org/obo/DOID_0060084,,,,,,,,A cell type benign neoplasm that is composed_of epithelial tissue in which tumor cells form glands or glandlike structures.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:657,,,DOID:2655,NCI:C2855|SNOMEDCT_US_2016_03_01:79041005|UMLS_CUI:C0001430|SNOMEDCT_US_2016_03_01:189579004|SNOMEDCT_US_2016_03_01:443416007|SNOMEDCT_US_2016_03_01:189578007|MESH:D000236|UMLS_CUI:C0334389|SNOMEDCT_US_2016_03_01:32048006|NCI:C4196,acinar cell adenoma|acinic cell adenoma|acinar cell adenoma (morphologic abnormality)|adenomas,,disease_ontology,adenoma,DOID:657,,,,,,,,,,,,,,,,,,,adenoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001201,"[""rosette""]",,"A cluster of leaves in crowded circles or spirals arising basally from a crown, as in the dandelion, or apically from an axis with greatly shortened internodes, as in many tropical palms.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A cluster of leaves in crowded circles or spirals arising basally from a crown, as in the dandelion, or apically from an axis with greatly shortened internodes, as in many tropical palms.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001201,,,,,,,BrendaTissueOBO,,BTO:0001201,,,,,,,,,,,,,,,,,,,rosette,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217571,"[""NR4A2 gene""]",,"This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_00217475,,,,,,,,"This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217571,,,,,,,,,,,,,,,,4929,NR4A2,NOT|NURR1|TINUR,,,,,,,,,,NR4A2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400494,"[""Alpha-5/CHRNA5 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400494,,,,,,,,,,,,,,,,,,,,,,,,,,,,Alpha-5/CHRNA5 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200287,"[""NTSR2 gene""]",,"A neurotensin receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95665] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400072,,,,,,,,"A neurotensin receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95665] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200287,,,,,,,,,,,,,,,,23620,NTSR2,,,,,,,,,,,NTSR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100794,"[""Taste receptor type 2 member 3""]",,"A taste receptor type 2 member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300014,,,,,,,,"A taste receptor type 2 member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100794,,,,https://pharos.nih.gov/idg/targets/Q9NYW6,,,,,,,,,,,,,TAS2R3,,,Q9NYW6,,,,,,,,Taste receptor type 2 member 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12399,"[""pathological gambling""]",,"An impulse control disorder that involves the uncontrollable impulse to gamble, irrespective of the interference the behaviour has on the individual's life.",false,,,http://purl.obolibrary.org/obo/DOID_10937,,,,,,,,"An impulse control disorder that involves the uncontrollable impulse to gamble, irrespective of the interference the behaviour has on the individual's life.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12399,,,,SNOMEDCT_US_2016_03_01:284524008|UMLS_CUI:C0030662|ICD9CM:312.31|MESH:D005715|NCI:C94335|SNOMEDCT_US_2016_03_01:18085000|ICD10CM:F63.0|OMIM:606349|SNOMEDCT_US_2016_03_01:192501004,Compulsive gambling|Pathological gambling,,disease_ontology,,DOID:12399,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,pathological gambling,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12397,"[""entropion""]",,,false,,,http://purl.obolibrary.org/obo/DOID_530,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12397,,,DOID:14446,MESH:D004774|ICD9CM:374.00|UMLS_CUI:C0014390|SNOMEDCT_US_2016_03_01:155177005|SNOMEDCT_US_2016_03_01:246821008|SNOMEDCT_US_2016_03_01:33168009|SNOMEDCT_US_2016_03_01:193928005,,,disease_ontology,,DOID:12397,,,,,,,,,,,,,,,,,,,entropion,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_917,"[""liver leiomyoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_916|http://purl.obolibrary.org/obo/DOID_409|http://purl.obolibrary.org/obo/DOID_127,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:917,,,,UMLS_CUI:C1333968|NCI:C5753,leiomyoma of the Liver,,disease_ontology,,DOID:917,,,,,,,,,,,,,,,,,,,liver leiomyoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_916,"[""liver neoplasm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3117,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:916,,,DOID:692,NCI:C7106|NCI:C7103|UMLS_CUI:C1333976|UMLS_CUI:C1333419,epithelial hepatic and intrahepatic bile duct neoplasm,,disease_ontology,,DOID:916,,,,,,,,,,,,,,,,,,,liver neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200430,"[""OR52N1 gene""]",,"An olfactory receptor 52N1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH53] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 52N1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH53] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200430,,,,,,,,,,,,,,,,79473,OR52N1,,,,,,,,,,,OR52N1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100627,"[""Uridine-cytidine kinase-like 1""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100627,,,,,,,,,,,,,,,,,UCKL1,,,Q9NWZ5,,,,,,,,Uridine-cytidine kinase-like 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200379,"[""OR4C45 gene""]",,"An olfactory receptor 4C45 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NMZ5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4C45 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NMZ5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200379,,,,,,,,,,,,,,,,403257,OR4C45,,,,,,,,,,,OR4C45 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80337,"[""Calcitonin gene-related peptide 1""]",Calcitonin-related polypeptide alpha|alpha-CGRP,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16125,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,Calcitonin-related polypeptide alpha|alpha-CGRP,,,CHEBI:80337,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80337,,,,,Calcitonin gene-related peptide 1,,CHEBI:80337,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100108,"[""Gamma-aminobutyric acid receptor subunit alpha-2""]",,"A gamma-aminobutyric acid receptor subunit alpha-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47869] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300507,,,,,,,,"A gamma-aminobutyric acid receptor subunit alpha-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47869] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100108,,,,https://pharos.nih.gov/idg/targets/P47869,,,,,,,,,,,,,GABRA2,,,P47869,,,,,,,,Gamma-aminobutyric acid receptor subunit alpha-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200094,"[""CSNK2B gene""]",,"This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400142,,,,,,,,"This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200094,,,,,,,,,,,,,,,,1460,CSNK2B,CK2N|G5A,,,,,,,,,,CSNK2B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300483,"[""LTrpC subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300360,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300483,,,,,,,,,,,,,,,,,,,,,,,,,,,,LTrpC subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13003,"[""vertebrobasilar insufficiency""]",,,false,,,http://purl.obolibrary.org/obo/DOID_224,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13003,,,,SNOMEDCT_US_2016_03_01:155404005|UMLS_CUI:C0042568|MESH:D014715|SNOMEDCT_US_2016_03_01:394517009|ICD9CM:435.3|SNOMEDCT_US_2016_03_01:266314007|SNOMEDCT_US_2016_03_01:64009001|SNOMEDCT_US_2016_03_01:195199008|ICD10CM:G45.0|SNOMEDCT_US_2016_03_01:195196001,Vertebrobasilar artery syndrome|Vertebrobasilar arterial insufficiency|Vertebrobasilar artery syndrome (disorder)|Vertebrobasilar insufficiency|Vertebro-basilar insufficiency,,disease_ontology,,DOID:13003,,,,,,,,,,,,,,,,,,,vertebrobasilar insufficiency,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100415,"[""Phosphatidylinositol 4-phosphate 5-kinase type-1 beta""]",,"A phosphatidylinositol 4-phosphate 5-kinase type-1 beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14986] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300323,,,,,,,,"A phosphatidylinositol 4-phosphate 5-kinase type-1 beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14986] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100415,,,,https://pharos.nih.gov/idg/targets/O14986,,,,,,,,,,,,,PIP5K1B,STM7,,O14986,,,,,,,,Phosphatidylinositol 4-phosphate 5-kinase type-1 beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003445,"[""carotid atherosclerotic plaque""]",,Cholesterol plaques on the inner wall of the carotid artery can lead to stroke.,false,,,http://purl.obolibrary.org/obo/BTO_0003120|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Cholesterol plaques on the inner wall of the carotid artery can lead to stroke.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003445,,,,,,,BrendaTissueOBO,atherosclerotic carotid plaque|carotid plaque,BTO:0003445,,,,,,,,,,,,,,,,,,,carotid atherosclerotic plaque,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300042,"[""Glycoprotein hormone receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300042,,,,,,,,,,,,,,,,,,,,,,,,,,,,Glycoprotein hormone receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100025,"[""K255 in ABL1(E255K)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100025,,,,,,,,,,,,,,,,,,,,,,,,,,,,K255 in ABL1(E255K),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217549,"[""HNF4A gene""]",,"The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_00217467,,,,,,,,"The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217549,,,,,,,,,,,,,,,,3172,HNF4A,HNF4|NR2A1|TCF14,,,,,,,,,,HNF4A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200374,"[""OR2T34 gene""]",,"An olfactory receptor 2T34 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2T34 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200374,,,,,,,,,,,,,,,,127068,OR2T34,,,,,,,,,,,OR2T34 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003696,"[""ATRkd cell""]",,Human osteosarcoma-derived U2OS cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human osteosarcoma-derived U2OS cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003696,,,,,,,BrendaTissueOBO,,BTO:0003696,,,,,,,,,,,,,,,,,,,ATRkd cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001027,"[""peripheral nerve""]",,"The peripheral nerves include the 12 cranial nerves, the spinal nerves and roots, and what are called the autonomic nerves that are concerned specifically with the regulation of the heart muscle, the muscles in blood vessel walls, and glands.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The peripheral nerves include the 12 cranial nerves, the spinal nerves and roots, and what are called the autonomic nerves that are concerned specifically with the regulation of the heart muscle, the muscles in blood vessel walls, and glands.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001027,,,,,,,BrendaTissueOBO,,BTO:0001027,,,,,,,,,,,,,,,,,,,peripheral nerve,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200606,"[""OR4Q3 gene""]",,"An olfactory receptor 4Q3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH05] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4Q3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH05] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200606,,,,,,,,,,,,,,,,441669,OR4Q3,C14orf13|OR4Q4,,,,,,,,,,OR4Q3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200036,"[""CACNA2D3 gene""]",,"This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400332,,,,,,,,"This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200036,,,,,,,,,,,,,,,,55799,CACNA2D3,,,,,,,,,,,CACNA2D3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100076,"[""C-X-C chemokine receptor type 2""]",,"A C-X-C chemokine receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25025] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300031,,,,,,,,"A C-X-C chemokine receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25025] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100076,,,,https://pharos.nih.gov/idg/targets/P25025,,,,,,,,,,,,,CXCR2,IL8RB,,P25025,,,,,,,,C-X-C chemokine receptor type 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002590,"[""HEY cell""]",,Human ovarian carcinoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000811,,,,,,,,Human ovarian carcinoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002590,,,,,,,BrendaTissueOBO,,BTO:0002590,,,,,,,,,,,,,,,,,,,HEY cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100229,"[""Thymidine kinase, cytosolic""]",,"A thymidine kinase, cytosolic that is encoded in the genome of human. [PRO:DNx, UniProtKB:P04183] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391015,,,,,,,,"A thymidine kinase, cytosolic that is encoded in the genome of human. [PRO:DNx, UniProtKB:P04183] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100229,,,,https://pharos.nih.gov/idg/targets/P04183,,,,,,,,,,,,,TK1,,,P04183,,,,,,,,"Thymidine kinase, cytosolic",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002767,"[""GH4-C1 cell""]",,Rat pituitary tumor cell line; established from a pituitary tumor of a 7-month-old female Wistar/Furth rat. Cell line GH4 was subcloned in order to obtain a cell line secreting high amounts of growth hormones.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000756,,,,,,,,Rat pituitary tumor cell line; established from a pituitary tumor of a 7-month-old female Wistar/Furth rat. Cell line GH4 was subcloned in order to obtain a cell line secreting high amounts of growth hormones.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002767,,,,,,,BrendaTissueOBO,GH4C1 cell,BTO:0002767,,,,,,,,,,,,,,,,,,,GH4-C1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100221,"[""Metabotropic glutamate receptor 4""]",,"A metabotropic glutamate receptor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14833] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300059,,,,,,,,"A metabotropic glutamate receptor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14833] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100221,,,,https://pharos.nih.gov/idg/targets/Q14833,,,,,,,,,,,,,GRM4,GPRC1D|MGLUR4,,Q14833,,,,,,,,Metabotropic glutamate receptor 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000049,"[""LEU131 in RPS6KA5(Kin.Dom.1-N-terminal)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000049,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU131 in RPS6KA5(Kin.Dom.1-N-terminal),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000113,"[""cervical ganglion""]",,Any of three sympathetic ganglia on each side of the neck.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001333,,,,,,,,Any of three sympathetic ganglia on each side of the neck.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000113,,,,,,,BrendaTissueOBO,,BTO:0000113,,,,,,,,,,,,,,,,,,,cervical ganglion,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000305,"[""MYO3A kinase domain""]",,Myosin IIIA; DFNB30; MYO3A,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Myosin IIIA; DFNB30; MYO3A,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000305,,,,,,,,,,,,,,,,,,,200282,,,,,,,,,MYO3A kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000027,"[""PrP106-126""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000027,,,,,,,,,,,,,,,,,,,,,,,,,,,,PrP106-126,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217471,"[""Coup-tf-like receptors gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00200002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217471,,,,,,,,,,,,,,,,,,,,,,,,,,,,Coup-tf-like receptors gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400321,"[""ChaK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400123,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400321,,,,,,,,,,,,,,,,,,,,,,,,,,,,ChaK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200507,"[""OR1S2 gene""]",,"An olfactory receptor 1S2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1S2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200507,,,,,,,,,,,,,,,,219958,OR1S2,,,,,,,,,,,OR1S2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000132,"[""EIF2AK1 kinase domain""]",,Eukaryotic translation initiation factor 2-alpha kinase 1; EIF2AK1; HCR; HRI; KIAA1369,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Eukaryotic translation initiation factor 2-alpha kinase 1; EIF2AK1; HCR; HRI; KIAA1369,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000132,,,,,,,,,,,,,,,,,,,200134,,,,,,,,,EIF2AK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002887,"[""A-9 cell""]",,"Mouse, C3H/An; tissue: areolar and adipose; derived from NCTC clone 929.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Mouse, C3H/An; tissue: areolar and adipose; derived from NCTC clone 929.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002887,,,,,,,BrendaTissueOBO,A9 cell,BTO:0002887,,,,,,,,,,,,,,,,,,,A-9 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000301,"[""SER282 in ACVR1B""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29999,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000301,,,,,,,,,,,,,,,,,,,,,,,,,,,,SER282 in ACVR1B,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003040,"[""uterine adenocarcinoma cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0001555|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003040,,,,,,,BrendaTissueOBO,endometrial adenocarcinoma cell line,BTO:0003040,,,,,,,,,,,,,,,,,,,uterine adenocarcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000568,"[""HeLa-S3 cell""]",,Human cervix carcinoma cell line is a subclone of its parent HELA derived in 1955.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human cervix carcinoma cell line is a subclone of its parent HELA derived in 1955.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000568,,,,,,,BrendaTissueOBO,HeLa S3 cell,BTO:0000568,,,,,,,,,,,,,,,,,,,HeLa-S3 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491039,"[""Phosphorylase b kinase regulatory chain family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400102,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491039,,,,,,,,,,,,,,,,,,,,,,,,,,,,Phosphorylase b kinase regulatory chain family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004494,"[""RGM-1 cell""]",,Normal rat gastric epithelial cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0004493,,,,,,,,Normal rat gastric epithelial cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004494,Marion,2010-02-04T05:39:49Z,,,,,BrendaTissueOBO,,BTO:0004494,,,,,,,,,,,,,,,,,,,RGM-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100026,"[""Acid-sensing ion channel 2""]",,"An acid-sensing ion channel 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16515] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300377,,,,,,,,"An acid-sensing ion channel 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16515] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100026,,,,https://pharos.nih.gov/idg/targets/Q16515,,,,,,,,,,,,,ASIC2,ACCN|ACCN1|BNAC1|MDEG,,Q16515,,,,,,,,Acid-sensing ion channel 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3480,"[""uveal disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5614,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3480,,,,MESH:D014603|SNOMEDCT_US_2016_03_01:95678007|NCI:C26908|UMLS_CUI:C0042161,,,disease_ontology,,DOID:3480,,,,,,,,,,,,,,,,,,,uveal disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000355,"[""PIM1 kinase domain""]",,Pim-1 oncogene; PIM; PIM1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Pim-1 oncogene; PIM; PIM1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000355,,,,,,,,,,,,,,,,,,,200337,,,,,,,,,PIM1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100497,"[""Olfactory receptor 1l3""]",,"An olfactory receptor 1L3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH93] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1L3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH93] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100497,,,,https://pharos.nih.gov/idg/targets/Q8NH93,,,,,,,,,,,,,OR1L3,,,Q8NH93,,,,,,,,Olfactory receptor 1l3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100050,"[""S2019 in LRRK2(G2019S)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100050,,,,,,,,,,,,,,,,,,,,,,,,,,,,S2019 in LRRK2(G2019S),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1024,"[""leprosy""]",,"A primary bacterial infectious disease that results_in infection located_in superficial peripheral nerves, located_in skin, located_in mucous membranes of the upper respiratory tract, located_in anterior chamber of the eyes, or located_in testes, has_material_basis_in Mycobacterium leprae, which is transmitted_by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. The infection has_symptom skin lesions, has_symptom sensory loss, has_symptom motor loss and has_symptom eye damage.",false,,,http://purl.obolibrary.org/obo/DOID_0050338,,,,,,,,"A primary bacterial infectious disease that results_in infection located_in superficial peripheral nerves, located_in skin, located_in mucous membranes of the upper respiratory tract, located_in anterior chamber of the eyes, or located_in testes, has_material_basis_in Mycobacterium leprae, which is transmitted_by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. The infection has_symptom skin lesions, has_symptom sensory loss, has_symptom motor loss and has_symptom eye damage.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1024,,,,ICD10CM:A30.9|SNOMEDCT_US_2016_03_01:154298007|SNOMEDCT_US_2016_03_01:186339006|UMLS_CUI:C0023343|OMIM:609888|OMIM:613223|ICD10CM:A30|MESH:D007918|ICD9CM:030|SNOMEDCT_US_2016_03_01:81004002|NCI:C84824|SNOMEDCT_US_2016_03_01:266184007|ICD9CM:030.9|OMIM:607572|SNOMEDCT_US_2016_03_01:187316006|EFO:0001054|OMIM:613407|OMIM:246300|OMIM:610988|ORDO:548,,,disease_ontology,,DOID:1024,http://purl.obolibrary.org/obo/doid#gram-positive_bacterial_infectious_disease|http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,leprosy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10242,"[""ehrlichiosis""]",,"A primary bacterial infectious disease that results_in infection located_in leukocyte, has_material_basis_in Ehrlichia chaffeensis or Anaplasma phagocytophilum, which are transmitted_by lone start stick and transmitted_by black-legged tick respectively. The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue and has_symptom rash.",false,,,http://purl.obolibrary.org/obo/DOID_0050338,,,,,,,,"A primary bacterial infectious disease that results_in infection located_in leukocyte, has_material_basis_in Ehrlichia chaffeensis or Anaplasma phagocytophilum, which are transmitted_by lone start stick and transmitted_by black-legged tick respectively. The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue and has_symptom rash.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10242,,,DOID:0050023,ICD9CM:082.40|SNOMEDCT_US_2016_03_01:77361002|ICD9CM:082.4|ICD10CM:A77.4|UMLS_CUI:C0085399|MESH:D016873|ICD10CM:A77.40,human ehrlichiosis,,disease_ontology,,DOID:10242,http://purl.obolibrary.org/obo/doid#tick-borne_infectious_disease|http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease,,,,,,,,,,,,,,,,,,ehrlichiosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10241,"[""thalassemia""]",,OMIM mapping confirmed by DO. [LS].,false,,,http://purl.obolibrary.org/obo/DOID_0050737,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10241,,,DOID:12242|DOID:12243,SNOMEDCT_US_2016_03_01:154796005|SNOMEDCT_US_2016_03_01:40108008|SNOMEDCT_US_2016_03_01:84188003|UMLS_CUI:C0039730|NCI:C35069|OMIM:604131|SNOMEDCT_US_2016_03_01:191193003|ICD10CM:D56.9|ICD9CM:282.4|SNOMEDCT_US_2016_03_01:267521001|SNOMEDCT_US_2016_03_01:267557006|MESH:D013789|SNOMEDCT_US_2016_03_01:191182000|ICD10CM:D56|SNOMEDCT_US_2016_03_01:191192008|ICD9CM:282.40,Sickle-cell thalassemia without crisis|Sickle-cell thalassemia with crisis|thalassemia Hb-S disease without crisis|thalassemia Hb-S disease with crisis,,disease_ontology,,DOID:10241,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,thalassemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000389,"[""ROS1 kinase domain""]",,"C-ros oncogene 1 , receptor tyrosine kinase; c-ros-1; MCF3; ROS; ROS1",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"C-ros oncogene 1 , receptor tyrosine kinase; c-ros-1; MCF3; ROS; ROS1",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000389,,,,,,,,,,,,,,,,,,,200383,,,,,,,,,ROS1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491014,"[""Adenylate kinase family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400326,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491014,,,,,,,,,,,,,,,,,,,,,,,,,,,,Adenylate kinase family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200240,"[""PRKD3 gene""]",,"Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. This kinase can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phopholipase C gamma and the involvement of other PKC family members. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400176,,,,,,,,"Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. This kinase can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phopholipase C gamma and the involvement of other PKC family members. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200240,,,,,,,,,,,,,,,,23683,PRKD3,EPK2|PRKCN,,,,,,,,,,PRKD3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200333,"[""TRPV1 gene""]",,"Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400590,,,,,,,,"Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200333,,,,,,,,,,,,,,,,7442,TRPV1,VR1,,,,,,,,,,TRPV1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100363,"[""Serine/threonine-protein kinase nek9""]",,"serine/threonine-protein kinase nek9 (NEK9)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase Nek9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TD19] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300197,,,,,,,,"serine/threonine-protein kinase nek9 (NEK9)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase Nek9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TD19] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100363,,,,https://pharos.nih.gov/idg/targets/Q8TD19,,,,,,,,,,,,,NEK9,KIAA1995|NEK8|NERCC,,Q8TD19,,,,,,,,Serine/threonine-protein kinase nek9,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200004,"[""HTR1E gene""]",,"A 5-hydroxytryptamine receptor 1E that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28566] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402001,,,,,,,,"A 5-hydroxytryptamine receptor 1E that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28566] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200004,,,,,,,,,,,,,,,,3354,HTR1E,,,,,,,,,,,HTR1E gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3369,"[""Ewing sarcoma""]",,"A bone cancer that has_material_basis in neural crest cells derives_from undeveloped, undifferentiated neuroectoderm.",false,,,http://purl.obolibrary.org/obo/DOID_184,,,,,,,,"A bone cancer that has_material_basis in neural crest cells derives_from undeveloped, undifferentiated neuroectoderm.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3369,,,DOID:4392|DOID:4390|DOID:4158|DOID:0050607|DOID:4391|DOID:4980,MESH:C563168|SNOMEDCT_US_2016_03_01:253096008|MESH:D018241|SNOMEDCT_US_2016_03_01:76909002|SNOMEDCT_US_2016_03_01:703707001|UMLS_CUI:C0684337|SNOMEDCT_US_2016_03_01:73676002|NCI:C27903|OMIM:612219|NCI:C7542|UMLS_CUI:C0877849|NCI:C9341|UMLS_CUI:C0863029|UMLS_CUI:C1334408|SNOMEDCT_US_2016_03_01:134210007|NCI:C4817|UMLS_CUI:C0796547|NCI:C7806|SNOMEDCT_US_2016_03_01:128783001|UMLS_CUI:C0553580|NCI:C27901|SNOMEDCT_US_2016_03_01:73506006|MESH:D012512,peripheral primitive neuroectodermal tumor|Ewings sarcoma|localized Ewing's sarcoma/peripheral primitive neuroectodermal tumor|Ewings sarcoma-primitive neuroectodermal tumor|localized Ewing sarcoma|PNET of Thoracopulmonary Region|Ewing's tumor|localized Ewing's sarcoma|localized Ewing's tumor|localized peripheral primitive neuroectodermal tumor|Ewing's sarcoma/peripheral primitive neuroectodermal tumor|Ewing's family localized tumor,,disease_ontology,,DOID:3369,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Ewing sarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100058,"[""Voltage-dependent calcium channel gamma-4 subunit""]",,"A voltage-dependent calcium channel gamma-4 subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UBN1] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300336,,,,,,,,"A voltage-dependent calcium channel gamma-4 subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UBN1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100058,,,,https://pharos.nih.gov/idg/targets/Q9UBN1,,,,,,,,,,,,,CACNG4,,,Q9UBN1,,,,,,,,Voltage-dependent calcium channel gamma-4 subunit,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400037,"[""Dopamine receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400037,,,,,,,,,,,,,,,,,,,,,,,,,,,,Dopamine receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002323,"[""eccrine sweat gland""]",,"An ordinary, or simple, sweat gland; they are of the merocrine type, unbranched, coiled, tubular glands that are distributed over almost all of the body surface, and promote cooling by evaporation of their secretion.",false,,,http://purl.obolibrary.org/obo/BTO_0001331|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002324,,,,,,,,"An ordinary, or simple, sweat gland; they are of the merocrine type, unbranched, coiled, tubular glands that are distributed over almost all of the body surface, and promote cooling by evaporation of their secretion.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002323,,,,,,,BrendaTissueOBO,eccrine gland,BTO:0002323,,,,,,,,,,,,,,,,,,,eccrine sweat gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400458,"[""NR2D/GRIN2D subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400458,,,,,,,,,,,,,,,,,,,,,,,,,,,,NR2D/GRIN2D subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001453,"[""detrusor""]",,The outer largely longitudinally arranged musculature of the bladder wall.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001260,,,,,,,,The outer largely longitudinally arranged musculature of the bladder wall.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001453,,,,,,,BrendaTissueOBO,detrusor muscle,BTO:0001453,,,,,,,,,,,,,,,,,,,detrusor,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100514,"[""Serine/threonine-protein kinase tao1""]",,"A serine/threonine-protein kinase TAO1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7L7X3] |serine/threonine-protein kinase tao1 (TAOK1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300318,,,,,,,,"A serine/threonine-protein kinase TAO1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7L7X3] |serine/threonine-protein kinase tao1 (TAOK1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100514,,,,https://pharos.nih.gov/idg/targets/Q7L7X3,,,,,,,,,,,,,TAOK1,KIAA1361|MAP3K16|MARKK,,Q7L7X3,,,,,,,,Serine/threonine-protein kinase tao1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200312,"[""TMC4 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400372,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200312,,,,,,,,,,,,,,,,147798,TMC4,,,,,,,,,,,TMC4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3319,"[""lymphangioleiomyomatosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_850,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3319,,,DOID:3682,UMLS_CUI:C0349649|NCI:C38153|SNOMEDCT_US_2016_03_01:277844007,pulmonary lymphangioleiomyomatosis|lymphangiomyomatosis|lung lymphangioleiomyomatosis,,disease_ontology,,DOID:3319,,,,,,,,,,,,,,,,,,,lymphangioleiomyomatosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100513,"[""Transcription initiation factor tfiid subunit 1""]",,A transcription initiation factor TFIID subunit 1 that is encoded in the genome of human. ,false,,,http://www.drugtargetontology.org/dto/DTO_03300231,,,,,,,,A transcription initiation factor TFIID subunit 1 that is encoded in the genome of human. ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100513,,,,https://pharos.nih.gov/idg/targets/P21675,,,,,,,,,,,,,TAF1,BA2R|CCG1|CCGS|TAF2A,,P21675,,,,,,,,Transcription initiation factor tfiid subunit 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200105,"[""FZD3 gene""]",,"A frizzled-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NPG1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400043,,,,,,,,"A frizzled-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NPG1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200105,,,,,,,,,,,,,,,,7976,FZD3,,,,,,,,,,,FZD3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100561,"[""Vascular endothelial growth factor receptor 3""]",,"A vascular endothelial growth factor receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35916] |vascular endothelial growth factor receptor 3 (FLT4)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300242,,,,,,,,"A vascular endothelial growth factor receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35916] |vascular endothelial growth factor receptor 3 (FLT4)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100561,,,,https://pharos.nih.gov/idg/targets/P35916,,,,,,,,,,,,,FLT4,VEGFR3,,P35916,,,,,,,,Vascular endothelial growth factor receptor 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400436,"[""A (Shaker) subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400436,,,,,,,,,,,,,,,,,,,,,,,,,,,,A (Shaker) subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000208,"[""MET83 in NEK4""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000208,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET83 in NEK4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200750,"[""PROKR2 gene""]",,"A prokineticin receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8NFJ6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A prokineticin receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8NFJ6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200750,,,,,,,,,,,,,,,,128674,PROKR2,GPR73L1|PKR2,,,,,,,,,,PROKR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491019,"[""Inositol phosphokinase (IPK) family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400323,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491019,,,,,,,,,,,,,,,,,,,,,,,,,,,,Inositol phosphokinase (IPK) family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3458,"[""breast adenocarcinoma""]",,A breast carcinoma that originates in the milk ducts and/or lobules (glandular tissue) of the breast.,false,,,http://purl.obolibrary.org/obo/DOID_299|http://purl.obolibrary.org/obo/DOID_3459,,,,,,,,A breast carcinoma that originates in the milk ducts and/or lobules (glandular tissue) of the breast.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3458,,,,UMLS_CUI:C0858252|NCI:C5214,Mammary adenocarcinoma,,disease_ontology,adenocarcinoma of breast,DOID:3458,,,,,,,,,,,,,,,,,,,breast adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100575,"[""Olfactory receptor 4c15""]",,"An olfactory receptor 4C15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGM1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4C15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGM1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100575,,,,https://pharos.nih.gov/idg/targets/Q8NGM1,,,,,,,,,,,,,OR4C15,,,Q8NGM1,,,,,,,,Olfactory receptor 4c15,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200306,"[""SCNN1G gene""]",,"Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome. [provided by RefSeq, Apr 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400480,,,,,,,,"Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome. [provided by RefSeq, Apr 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200306,,,,,,,,,,,,,,,,6340,SCNN1G,,,,,,,,,,,SCNN1G gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117525,"[""Nuclear receptor subfamily 6 group a member 1""]",,"A nuclear receptor subfamily 6 group A member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15406] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117477,,,,,,,,"A nuclear receptor subfamily 6 group A member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15406] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117525,,,,https://pharos.nih.gov/idg/targets/Q15406,,,,,,,,,,,,,NR6A1,,,Q15406,,,,,,,,Nuclear receptor subfamily 6 group a member 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200159,"[""GK2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491021,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200159,,,,,,,,,,,,,,,,2712,GK2,GKP2|GKTA,,,,,,,,,,GK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400435,"[""KCNJ9 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400435,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ9 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100272,"[""Neuromedin-K receptor""]",,"A neuromedin-K receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P29371] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300066,,,,,,,,"A neuromedin-K receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P29371] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100272,,,,https://pharos.nih.gov/idg/targets/P29371,,,,,,,,,,,,,TACR3,NK3R|TAC3R,,P29371,,,,,,,,Neuromedin-K receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200199,"[""KCNE4 gene""]",,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400445,,,,,,,,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200199,,,,,,,,,,,,,,,,23704,KCNE4,,,,,,,,,,,KCNE4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400510,"[""GABRA5 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400510,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRA5 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1876,"[""sexual dysfunction""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060043,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1876,,,,MESH:D012735|UMLS_CUI:C0549622|SNOMEDCT_US_2016_03_01:39894007|SNOMEDCT_US_2016_03_01:231532002|ICD10CM:R37|SNOMEDCT_US_2016_03_01:65655009|ICD10CM:F52.9|SNOMEDCT_US_2016_03_01:56925008|NCI:C3347|SNOMEDCT_US_2016_03_01:225723003,,,disease_ontology,,DOID:1876,,,,,,,,,,,,,,,,,,,sexual dysfunction,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5327,"[""retinal detachment""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5679,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5327,,,,SNOMEDCT_US_2016_03_01:193347002|ICD9CM:361.9|SNOMEDCT_US_2016_03_01:42059000|NCI:C26874|SNOMEDCT_US_2016_03_01:155103005|ICD10CM:H33.2|UMLS_CUI:C0035305|MESH:D012163,,,disease_ontology,,DOID:5327,,,,,,,,,,,,,,,,,,,retinal detachment,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100219,"[""Potassium channel subfamily k member 7""]",,"A potassium channel subfamily K member 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y2U2] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300359,,,,,,,,"A potassium channel subfamily K member 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y2U2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100219,,,,https://pharos.nih.gov/idg/targets/Q9Y2U2,,,,,,,,,,,,,KCNK7,,,Q9Y2U2,,,,,,,,Potassium channel subfamily k member 7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400056,"[""Estrogen (G protein-coupled) receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400056,,,,,,,,,,,,,,,,,,,,,,,,,,,,Estrogen (G protein-coupled) receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_18243,"[""Dopamine""]","a-(3,4-Dihydroxyphenyl)-b-aminoethane|Hydroxytyramin|3,4-Dihydroxyphenylethylamine|2-(3,4-Dihydroxyphenyl)ethylamine|Revivan|Deoxyepinephrine|C8H11NO2|NCCc1ccc(O)c(O)c1|4-(2-aminoethyl)catechol|dopamine|3,4-Dihydroxyphenethylamine|Dopaminum|dopaminum|4-(2-azanylethyl)benzene-1,2-diol|4-(2-Aminoethyl)-Pyrocatechol|Hydroxytyramine|alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane|4-(2-Aminoethyl)-1,2-benzenediol|Dynatra|Dopamin|4-(2-aminoethyl)pyrocatechol|VYFYYTLLBUKUHU-UHFFFAOYSA-N|4-(2-Aminoethyl)benzene-1,2-diol|3-Hydroxytyramine|L-DOPAMINE|Dopastat|dopamina|Oxytyramine|4-(2-aminoethyl)-1,2-benzenediol|
InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2
|2-(3,4-dihydroxyphenyl)ethylamine|Intropin|Dophamine","
Catechol in which the hydrogen at position 4 is substituted by a 2-aminoethyl group.
",false,,,http://purl.obolibrary.org/obo/CHEBI_32952,,,,,,,CiteXplore:16757377|CiteXplore:7059264|HMDB:HMDB00073|CiteXplore:6085021|ChemIDplus:51-61-6|CiteXplore:9360553|CiteXplore:16412483|CiteXplore:14561867|KEGG COMPOUND:C03758|CiteXplore:11477488|CiteXplore:16818870|CiteXplore:10494443|MetaCyc:DOPAMINE|CiteXplore:16146016|CiteXplore:10489384|CiteXplore:8884658|CiteXplore:12649306|CiteXplore:11805404|Wikipedia:Dopamine|CiteXplore:9849813|CiteXplore:12622787|KNApSAcK:C00001408|PDBeChem:LDP|CiteXplore:16601073|CiteXplore:7161364|CiteXplore:16806124|CiteXplore:16449954|CiteXplore:12834252|CiteXplore:17237217|CiteXplore:11149432|CiteXplore:16317894|CiteXplore:17031479|CiteXplore:15080725|CiteXplore:9858756|KEGG DRUG:D07870|CiteXplore:10629745|Reaxys:1072822|CiteXplore:9422813|DrugBank:DB00988|KEGG COMPOUND:62-31-7|CiteXplore:20669995,"
Catechol in which the hydrogen at position 4 is substituted by a 2-aminoethyl group.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:14203|CHEBI:23886|CHEBI:1764|CHEBI:11695|CHEBI:11930|CHEBI:43686,,"4-(2-aminoethyl)benzene-1,2-diol|Dopamine",,chebi_ontology,"a-(3,4-Dihydroxyphenyl)-b-aminoethane|Hydroxytyramin|3,4-Dihydroxyphenylethylamine|2-(3,4-Dihydroxyphenyl)ethylamine|Revivan|Deoxyepinephrine|C8H11NO2|NCCc1ccc(O)c(O)c1|4-(2-aminoethyl)catechol|dopamine|3,4-Dihydroxyphenethylamine|Dopaminum|dopaminum|4-(2-azanylethyl)benzene-1,2-diol|4-(2-Aminoethyl)-Pyrocatechol|Hydroxytyramine|alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane|4-(2-Aminoethyl)-1,2-benzenediol|Dynatra|Dopamin|4-(2-aminoethyl)pyrocatechol|VYFYYTLLBUKUHU-UHFFFAOYSA-N|4-(2-Aminoethyl)benzene-1,2-diol|3-Hydroxytyramine|L-DOPAMINE|Dopastat|dopamina|Oxytyramine|4-(2-aminoethyl)-1,2-benzenediol|
InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2
|2-(3,4-dihydroxyphenyl)ethylamine|Intropin|Dophamine",,,CHEBI:18243,,,,,,,,,,,,,,,,,,,,,,,CHEBI:18243,,,,,dopamine|Dopamine,,CHEBI:18243,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217574,"[""NR5A2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00217476,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217574,,,,,,,,,,,,,,,,2494,NR5A2,B1F|CPF|FTF,,,,,,,,,,NR5A2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8461,"[""Aicardi syndrome""]",,"A syndrome that is characterized by absence or underdeveloped tissue connecting the left and right halves of the brain, infantile spasms and chorioretinal lacunae, which are defects in the light-sensitive tissue at the back of the eye.",false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,"A syndrome that is characterized by absence or underdeveloped tissue connecting the left and right halves of the brain, infantile spasms and chorioretinal lacunae, which are defects in the light-sensitive tissue at the back of the eye.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8461,,,,MESH:D058540|SNOMEDCT_US_2016_03_01:80651009|NCI:C35256|ORDO:50|OMIM:304050|UMLS_CUI:C0175713,,,disease_ontology,,DOID:8461,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Aicardi syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000087,"[""CHEK1 kinase domain""]",,CHK1 checkpoint homolog (S. pombe); CHEK1; CHK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,CHK1 checkpoint homolog (S. pombe); CHEK1; CHK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000087,,,,,,,,,,,,,,,,,,,200087,,,,,,,,,CHEK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100505,"[""Ste20/sps1-related proline-alanine-rich protein kinase""]",,"STE20/sps1-related proline-alanine-rich protein kinase (STK39)  with  no mutation  in a nonphosphorylated state|A STE20/SPS1-related proline-alanine-rich protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UEW8] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300302,,,,,,,,"STE20/sps1-related proline-alanine-rich protein kinase (STK39)  with  no mutation  in a nonphosphorylated state|A STE20/SPS1-related proline-alanine-rich protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UEW8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100505,,,,https://pharos.nih.gov/idg/targets/Q9UEW8,,,,,,,,,,,,,STK39,SPAK,,Q9UEW8,,,,,,,,Ste20/sps1-related proline-alanine-rich protein kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_81559,"[""resolvin E1""]","5S,12R,18R-Trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid|C20H30O5|350.209|5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid|(6Z,8E,10E,14Z,16E)-5,12,18-trihydroxyicosa-6,8,10,14,16-pentaenoic acid|ResolvinE1|C(\[C@H](CCCC(O)=O)O)=C\C=C\C=C\[C@@H](C\C=C/C=C/[C@@H](CC)O)O|(5S,12R,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-icosapentaenoic acid|5S,12R,18R-Trihydroxy-6Z,8E,10E,14Z,16E-EPA|InChI=1S/C20H30O5/c1-2-17(21)11-8-5-9-14-18(22)12-6-3-4-7-13-19(23)15-10-16-20(24)25/h3-9,11-13,17-19,21-23H,2,10,14-16H2,1H3,(H,24,25)/b4-3+,9-5-,11-8+,12-6+,13-7-/t17-,18+,19-/m1/s1|RvE1|0|350.450|AOPOCGPBAIARAV-OTBJXLELSA-N|(5S,12R,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoic acid","A resolvin that is (6Z,8E,10E,14Z,16E)-icosa-6,8,10,14,16-pentaenoic acid which is substituted at positions 5, 12 and 18 by hydroxy groups (the 5S,12R,18R stereoisomer).",false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,HMDB:HMDB10410|PMID:20119897|PMID:22336459|PMID:22257864|PMID:16373400|LIPID_MAPS_instance:LMFA03070019|PMID:20708601|PMID:17339491|PMID:25681756|PMID:18480426|Reaxys:11884203|PMID:17131464|PMID:15753205|PMID:16112645|PMID:22951188|MetaCyc:CPD66-57|PMID:16757471|PMID:26438363|KEGG:C18171|PMID:18190790|PMID:25637017|PMID:22297737|PMID:17982093|PMID:19368495|PMID:18292578|PMID:24344649|PMID:25792445,"A resolvin that is (6Z,8E,10E,14Z,16E)-icosa-6,8,10,14,16-pentaenoic acid which is substituted at positions 5, 12 and 18 by hydroxy groups (the 5S,12R,18R stereoisomer).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,"(5S,6Z,8E,10E,12R,14Z,16E,18R)-5,12,18-trihydroxyicosa-6,8,10,14,16-pentaenoic acid",,chebi_ontology,"5S,12R,18R-Trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid|C20H30O5|350.209|5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid|(6Z,8E,10E,14Z,16E)-5,12,18-trihydroxyicosa-6,8,10,14,16-pentaenoic acid|ResolvinE1|C(\[C@H](CCCC(O)=O)O)=C\C=C\C=C\[C@@H](C\C=C/C=C/[C@@H](CC)O)O|(5S,12R,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-icosapentaenoic acid|5S,12R,18R-Trihydroxy-6Z,8E,10E,14Z,16E-EPA|InChI=1S/C20H30O5/c1-2-17(21)11-8-5-9-14-18(22)12-6-3-4-7-13-19(23)15-10-16-20(24)25/h3-9,11-13,17-19,21-23H,2,10,14-16H2,1H3,(H,24,25)/b4-3+,9-5-,11-8+,12-6+,13-7-/t17-,18+,19-/m1/s1|RvE1|0|350.450|AOPOCGPBAIARAV-OTBJXLELSA-N|(5S,12R,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoic acid",,,CHEBI:81559,,,,,,,,,,,,,,,,,,,,,,,CHEBI:81559,,,,,resolvin E1,,CHEBI:81559,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100182,"[""G-protein coupled receptor 1""]",,"A G-protein coupled receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46091] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46091] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100182,,,,https://pharos.nih.gov/idg/targets/P46091,,,,,,,,,,,,,GPR1,,,P46091,,,,,,,,G-protein coupled receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000035,"[""colorectal adenocarcinoma cell""]",,Adenocarcinoma cell related to the colon and/or rectum.,false,,,http://purl.obolibrary.org/obo/BTO_0000586|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000604|http://purl.obolibrary.org/obo/BTO_0000193,,,,,,,,Adenocarcinoma cell related to the colon and/or rectum.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000035,,,,,,,BrendaTissueOBO,"adenocarcinoma cell, colorectal",BTO:0000035,,,,,,,,,,,,,,,,,,,colorectal adenocarcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300022,"[""Adrenoceptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300022,,,,,,,,,,,,,,,,,,,,,,,,,,,,Adrenoceptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3324,"[""mood disorder""]",,"A cognitive disorder that involves an excessive, irrational dread of everyday situations.",false,,,http://purl.obolibrary.org/obo/DOID_1561,,,,,,,,"A cognitive disorder that involves an excessive, irrational dread of everyday situations.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3324,,,,UMLS_CUI:C0525045|SNOMEDCT_US_2016_03_01:74421008|NCI:C92200|ICD10CM:F30-F39|MESH:D019964|ICD10CM:F39|EFO:0004247|SNOMEDCT_US_2016_03_01:46206005|SNOMEDCT_US_2016_03_01:192391006|SNOMEDCT_US_2016_03_01:268713007|SNOMEDCT_US_2016_03_01:192348001,episodic mood disorder,,disease_ontology,,DOID:3324,,,,,,,,,,,,,,,,,Updating outdated UMLS CUI.,,mood disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8778,"[""Crohn's disease""]",,An intestinal disease that involves inflammation located_in intestine.,false,,,http://purl.obolibrary.org/obo/DOID_0050589,,,,,,,,An intestinal disease that involves inflammation located_in intestine.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8778,,,DOID:8855|DOID:8784|DOID:8942,ICD10CM:K50.1|SNOMEDCT_US_2016_03_01:196982002|NCI:C35211|SNOMEDCT_US_2016_03_01:155762006|UMLS_CUI:C0156147|SNOMEDCT_US_2016_03_01:7620006|SNOMEDCT_US_2016_03_01:50440006|ICD9CM:555.1|SNOMEDCT_US_2016_03_01:196981009|SNOMEDCT_US_2016_03_01:266446008|MESH:D003424|EFO:0000384|NCI:C37262,Crohn's disease of large bowel|Granulomatous Colitis|Crohn disease|Crohn's disease of colon (disorder)|Pediatric Crohn's disease,,disease_ontology,,DOID:8778,,,,,,,,,,,,,,,,,MESH:C536215 added from NeuroDevNet [WAK].,,Crohn's disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200127,"[""GLRA2 gene""]",,"The glycine receptor consists of two subunits, alpha and beta, and acts as a pentamer. The protein encoded by this gene is an alpha subunit and can bind strychnine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400526,,,,,,,,"The glycine receptor consists of two subunits, alpha and beta, and acts as a pentamer. The protein encoded by this gene is an alpha subunit and can bind strychnine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200127,,,,,,,,,,,,,,,,2742,GLRA2,,,,,,,,,,,GLRA2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100086,"[""Cyclic nucleotide-gated olfactory channel""]",,"A cyclic nucleotide-gated olfactory channel that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q16280] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300403,,,,,,,,"A cyclic nucleotide-gated olfactory channel that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q16280] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100086,,,,https://pharos.nih.gov/idg/targets/Q16280,,,,,,,,,,,,,CNGA2,CNCA|CNCA1|CNCG2,,Q16280,,,,,,,,Cyclic nucleotide-gated olfactory channel,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100646,"[""Olfactory receptor 5t2""]",,"An olfactory receptor 5T2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5T2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100646,,,,https://pharos.nih.gov/idg/targets/Q8NGG2,,,,,,,,,,,,,OR5T2,,,Q8NGG2,,,,,,,,Olfactory receptor 5t2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6271,"[""gastric cardia adenocarcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3717|http://purl.obolibrary.org/obo/DOID_6270,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6271,,,,UMLS_CUI:C1333762|NCI:C5247,adenocarcinoma of Cardia of stomach,,disease_ontology,adenocarcinoma of gastric cardia,DOID:6271,,,,,,,,,,,,,,,,,,,gastric cardia adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100504,"[""Olfactory receptor 1p1""]",,"An olfactory receptor 1P1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH06] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1P1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH06] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100504,,,,https://pharos.nih.gov/idg/targets/Q8NH06,,,,,,,,,,,,,OR1P1,OR1P1P,,Q8NH06,,,,,,,,Olfactory receptor 1p1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100180,"[""Potassium voltage-gated channel subfamily A member 1""]",,"A voltage-gated potassium channel subunit KCNA1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q09470] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300532,,,,,,,,"A voltage-gated potassium channel subunit KCNA1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q09470] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100180,,,,https://pharos.nih.gov/idg/targets/Q09470,,,,,,,,,,,,,KCNA1,,,Q09470,,,,,,,,Potassium voltage-gated channel subfamily A member 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1405,"[""primary angle-closure glaucoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_13550,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1405,,,,UMLS_CUI:C0017606|SNOMEDCT_US_2016_03_01:193547001|ICD10CM:H40.20|SNOMEDCT_US_2016_03_01:42456004|SNOMEDCT_US_2016_03_01:270882001|SNOMEDCT_US_2016_03_01:193544008|ICD9CM:365.20|ICD9CM:365.2|NCI:C34640|ICD10CM:H40.2|SNOMEDCT_US_2016_03_01:392288006|SNOMEDCT_US_2016_03_01:193545009|SNOMEDCT_US_2016_03_01:155123006,primary Angle Closure Glaucoma,,disease_ontology,,DOID:1405,,,,,,,,,,,,,,,,,,,primary angle-closure glaucoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000205,"[""JAK3(Kin.Dom.2) kinase domain""]",,Tyrosine-protein kinase JAK3; Janus kinase 3; JAK-3; L-JAK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Tyrosine-protein kinase JAK3; Janus kinase 3; JAK-3; L-JAK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000205,,,,,,,,,,,,,,,,,,,200210,,,,,,,,,JAK3(Kin.Dom.2) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003649,"[""anterior olfactory nucleus""]",,"A portion of the forebrain of vertebrates. It is found behind the olfactory bulb and in front of the piriform cortex (laterally) and olfactory tubercle (medially) in a region often referred to as the olfactory peduncle or retrobulbar area. The peduncle contains the anterior olfactory nucleus (AON) as well as two other much smaller regions, the tenia tecta (or dorsal hippocampal rudiment) and the dorsal peduncular cortex.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A portion of the forebrain of vertebrates. It is found behind the olfactory bulb and in front of the piriform cortex (laterally) and olfactory tubercle (medially) in a region often referred to as the olfactory peduncle or retrobulbar area. The peduncle contains the anterior olfactory nucleus (AON) as well as two other much smaller regions, the tenia tecta (or dorsal hippocampal rudiment) and the dorsal peduncular cortex.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003649,,,,,,,BrendaTissueOBO,AON|anterior olfactory cortex,BTO:0003649,,,,,,,,,,,,,,,,,,,anterior olfactory nucleus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200415,"[""PIP5K1B gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400323,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200415,,,,,,,,,,,,,,,,8395,PIP5K1B,STM7,,,,,,,,,,PIP5K1B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000165,"[""FLT3(D835H) kinase domain""]",,Fms-related tyrosine kinase 3; CD135; FLK2; FLK-2; FLT3; FLT-3; Ly72; STK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Fms-related tyrosine kinase 3; CD135; FLK2; FLK-2; FLT3; FLT-3; Ly72; STK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000165,,,,,,,,,,,,,,,,,,,200169,,,,,,,,,FLT3(D835H) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100034,"[""Voltage-dependent calcium channel subunit alpha-2/delta-1""]",,"A voltage-dependent calcium channel subunit alpha-2/delta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54289] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300332,,,,,,,,"A voltage-dependent calcium channel subunit alpha-2/delta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54289] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100034,,,,https://pharos.nih.gov/idg/targets/P54289,,,,,,,,,,,,,CACNA2D1,CACNL2A|CCHL2A|MHS3,,P54289,,,,,,,,Voltage-dependent calcium channel subunit alpha-2/delta-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200303,"[""MARK2 gene""]",,"This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400290,,,,,,,,"This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200303,,,,,,,,,,,,,,,,2011,MARK2,EMK1,,,,,,,,,,MARK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_28666,"[""leukotriene D4""]","5S-hydroxy-6R-(S-cysteinylglycinyl)-7E,9E,11E,14Z-eicosatetraenoic acid|LTD4|496.261|CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](N)C(=O)NCC(O)=O)[C@@H](O)CCCC(O)=O|YEESKJGWJFYOOK-IJHYULJSSA-N|C25H40N2O6S|InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1|496.66000|(R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-Carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-L-cysteinyl)glycine|0","A leukotriene that is (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid substituted by a hydroxy group at position 5 (5S) and a L-cysteinylglycinyl group at position 6 (6R).",false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,PMID:23825762|KEGG:C05951|Wikipedia:Leukotriene_D4|LIPID_MAPS_instance:LMFA03020006|Reaxys:4726738|CAS:73836-78-9|PMID:9160411|HMDB:HMDB03080,"A leukotriene that is (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid substituted by a hydroxy group at position 5 (5S) and a L-cysteinylglycinyl group at position 6 (6R).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:6423|CHEBI:25026,,"Leukotriene D4|S-{(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl}-L-cysteinylglycine",,chebi_ontology,"5S-hydroxy-6R-(S-cysteinylglycinyl)-7E,9E,11E,14Z-eicosatetraenoic acid|LTD4|496.261|CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](N)C(=O)NCC(O)=O)[C@@H](O)CCCC(O)=O|YEESKJGWJFYOOK-IJHYULJSSA-N|C25H40N2O6S|InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1|496.66000|(R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-Carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-L-cysteinyl)glycine|0",,,CHEBI:28666,,,,,,,,,,,,,,,,,,,,,,,CHEBI:28666,,,,,leukotriene D4,,CHEBI:28666,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13781,"[""hypermobility syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_381,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13781,,,,SNOMEDCT_US_2016_03_01:85551004|UMLS_CUI:C0152093|ICD9CM:728.5|SNOMEDCT_US_2016_03_01:156723005|ICD10CM:M35.7,hypermobility syndrome (disorder)|benign joint hypermobility,,disease_ontology,,DOID:13781,,,,,,,,,,,,,,,,,,,hypermobility syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200131,"[""GPR89A gene""]",,"GPR89A is a nearly identical copy of the GPR89B gene (MIM 612806).[supplied by OMIM, Jun 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400350,,,,,,,,"GPR89A is a nearly identical copy of the GPR89B gene (MIM 612806).[supplied by OMIM, Jun 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200131,,,,,,,,,,,,,,,,51463|653519,GPR89A,GPHRA|GPR89|SH120,,,,,,,,,,GPR89A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300055,"[""Bile acid receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300055,,,,,,,,,,,,,,,,,,,,,,,,,,,,Bile acid receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_36914,"[""inorganic ion""]",inorganic ions|.,,false,,,http://purl.obolibrary.org/obo/CHEBI_23367,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,inorganic ions|.,,,CHEBI:36914,,,,,,,,,,,,,,,,,,,,,,,CHEBI:36914,,,,,inorganic ion|Inorganic ion,,CHEBI:36914,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200498,"[""STK24 gene""]",,"This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400297,,,,,,,,"This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200498,,,,,,,,,,,,,,,,8428,STK24,MST3|STK3,,,,,,,,,,STK24 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1237,"[""corneal degeneration""]",,,false,,,http://purl.obolibrary.org/obo/DOID_10124,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1237,,,,ICD9CM:371.40|ICD10CM:H18.40|ICD9CM:371.4|SNOMEDCT_US_2016_03_01:193824006|UMLS_CUI:C0155118|SNOMEDCT_US_2016_03_01:193830006|SNOMEDCT_US_2016_03_01:111521006|ICD10CM:H18.4,,,disease_ontology,,DOID:1237,,,,,,,,,,,,,,,,,,,corneal degeneration,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12377,"[""spinal muscular atrophy""]",,A motor neuron disease that is a degenerative neuromuscular disease characterized by lower motor neuron degeneration associated with progressive muscle weakness and atrophy.,false,,,http://purl.obolibrary.org/obo/DOID_231,,,,,,,,A motor neuron disease that is a degenerative neuromuscular disease characterized by lower motor neuron degeneration associated with progressive muscle weakness and atrophy.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12377,,,,SNOMEDCT_US_2016_03_01:192885003|ICD9CM:335.1|SNOMEDCT_US_2016_03_01:192887006|ICD9CM:335.10|ICD10CM:G12.9|MESH:D009134|UMLS_CUI:C0026847|NCI:C85075|SNOMEDCT_US_2016_03_01:5262007,,,disease_ontology,,DOID:12377,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,spinal muscular atrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12375,"[""bronchopneumonia""]",,"A pneumonia involving inflammation of lungs that begins in the terminal bronchioles, which become clogged with thick mucus that forms consolidated patches in adjacent lobules. It is caused by bacteria and viruses.",false,,,http://purl.obolibrary.org/obo/DOID_552,,,,,,,,"A pneumonia involving inflammation of lungs that begins in the terminal bronchioles, which become clogged with thick mucus that forms consolidated patches in adjacent lobules. It is caused by bacteria and viruses.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12375,,,,MESH:D001996|SNOMEDCT_US_2016_03_01:195914001|SNOMEDCT_US_2016_03_01:266352008|UMLS_CUI:C0006285|NCI:C26710|SNOMEDCT_US_2016_03_01:155551009|SNOMEDCT_US_2016_03_01:67814005|ICD10CM:J18.0|SNOMEDCT_US_2016_03_01:396285007|ICD9CM:485,Chest infection - unspecified bronchopneumonia|bronchial pneumonia|lobular pneumonia,,disease_ontology,,DOID:12375,,,,,,,,,,,,,,,,,,,bronchopneumonia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3347,"[""osteosarcoma""]",,A bone cancer that is located_in bone that has_material_basis_in cells of mesenchymal origin.,false,,,http://purl.obolibrary.org/obo/DOID_1115|http://purl.obolibrary.org/obo/DOID_184,,,,,,,,A bone cancer that is located_in bone that has_material_basis_in cells of mesenchymal origin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3347,,,DOID:183,SNOMEDCT_US_2016_03_01:189878003|SNOMEDCT_US_2016_03_01:21708004|NCI:C9145|MESH:D018213|SNOMEDCT_US_2016_03_01:307576001|MESH:D012516|UMLS_CUI:C0206639|UMLS_CUI:C0029463|SNOMEDCT_US_2016_03_01:408387006|OMIM:259500,osteoid sarcoma|bone tissue neoplasm|Skeletal sarcoma|Osteogenic sarcoma,,disease_ontology,,DOID:3347,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,osteosarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000360,"[""PIP5K2B kinase domain""]",,"Phosphatidylinositol-5-phosphate 4-kinase, type II, beta; PI5P4KB; PIP4K2B; PIP5K2B; PIP5KIIB; PIP5KIIbeta",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Phosphatidylinositol-5-phosphate 4-kinase, type II, beta; PI5P4KB; PIP4K2B; PIP5K2B; PIP5KIIB; PIP5KIIbeta",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000360,,,,,,,,,,,,,,,,,,,200342,,,,,,,,,PIP5K2B kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200483,"[""SPHK2 gene""]",,"This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400323,,,,,,,,"This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200483,,,,,,,,,,,,,,,,56848,SPHK2,,,,,,,,,,,SPHK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200033,"[""ATM gene""]",,"The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400129,,,,,,,,"The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200033,,,,,,,,,,,,,,,,472,ATM,,,,,,,,,,,ATM gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000400,"[""RSK4(Kin.Dom.1-N-terminal) kinase domain""]",,"Ribosomal protein S6 kinase, 90kDa, polypeptide 6; PP90RSK4; RPS6KA6; RSK4",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Ribosomal protein S6 kinase, 90kDa, polypeptide 6; PP90RSK4; RPS6KA6; RSK4",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000400,,,,,,,,,,,,,,,,,,,"200397, 200404",,,,,,,,,RSK4(Kin.Dom.1-N-terminal) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000139,"[""EPHA7 kinase domain""]",,EPH receptor A7; EHK3; EPHA7; HEK11,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,EPH receptor A7; EHK3; EPHA7; HEK11,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000139,,,,,,,,,,,,,,,,,,,200141,,,,,,,,,EPHA7 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100060,"[""C-c chemokine receptor type 8""]",,"A C-C chemokine receptor type 8 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51685] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300095,,,,,,,,"A C-C chemokine receptor type 8 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51685] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100060,,,,https://pharos.nih.gov/idg/targets/P51685,,,,,,,,,,,,,CCR8,CKRL1|CMKBR8|CMKBRL2,,P51685,,,,,,,,C-c chemokine receptor type 8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100712,"[""Olfactory receptor 9A2""]",,"An olfactory receptor 9A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 9A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100712,,,,https://pharos.nih.gov/idg/targets/Q8NGT5,,,,,,,,,,,,,OR9A2,,,Q8NGT5,,,,,,,,Olfactory receptor 9A2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200246,"[""PRKCQ gene""]",,"Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400277,,,,,,,,"Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200246,,,,,,,,,,,,,,,,5588,PRKCQ,PRKCT,,,,,,,,,,PRKCQ gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100273,"[""Neuromedin-B receptor""]",,"A neuromedin-B receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28336] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300026,,,,,,,,"A neuromedin-B receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28336] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100273,,,,https://pharos.nih.gov/idg/targets/P28336,,,,,,,,,,,,,NMBR,,,P28336,,,,,,,,Neuromedin-B receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100551,"[""Uridine-cytidine kinase 1""]",,"A uridine-cytidine kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HA47] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391024,,,,,,,,"A uridine-cytidine kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HA47] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100551,,,,https://pharos.nih.gov/idg/targets/Q9HA47,,,,,,,,,,,,,UCK1,URK1,,Q9HA47,,,,,,,,Uridine-cytidine kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2548,"[""reflex epilepsy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0050706,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2548,,,,SNOMEDCT_US_2016_03_01:79745005|UMLS_CUI:C0270857|NCI:C85041|MESH:D020195,"epilepsy, sensory-induced",,disease_ontology,,DOID:2548,,,,,,,,,,,,,,,,,,,reflex epilepsy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14687,"[""diastrophic dysplasia""]",,An osteochondrodysplasia that has_material_basis_in abnormal cartilage development due to mutations in the SLC26A2 gene which results_in short limb dwarfism.,false,,,http://purl.obolibrary.org/obo/DOID_2256,,,,,,,,An osteochondrodysplasia that has_material_basis_in abnormal cartilage development due to mutations in the SLC26A2 gene which results_in short limb dwarfism.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14687,,,,UMLS_CUI:C0220726|MESH:C536170|SNOMEDCT_US_2016_03_01:58561002|ICD10CM:Q77.5|OMIM:222600,,,disease_ontology,,DOID:14687,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,diastrophic dysplasia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14681,"[""Silver-Russell syndrome""]",,OMIM mapping confirmed by DO. [LS].,false,,,http://purl.obolibrary.org/obo/DOID_0080014,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14681,,,,UMLS_CUI:C0175693|OMIM:180860|MESH:D056730|NCI:C85068|ICD10CM:Q87.1|SNOMEDCT_US_2016_03_01:15069006,Silver Russell Dwarfism,,disease_ontology,,DOID:14681,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,Silver-Russell syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2018,"[""hyperinsulinism""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4194|http://purl.obolibrary.org/obo/DOID_1428,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2018,,,,SNOMEDCT_US_2016_03_01:267477002|UMLS_CUI:C0020459|ICD10CM:E16.1|SNOMEDCT_US_2016_03_01:83469008|SNOMEDCT_US_2016_03_01:154694003|SNOMEDCT_US_2016_03_01:124860004|MESH:D006946|NCI:C113104|SNOMEDCT_US_2016_03_01:131103005,hyperinsulinemia,,disease_ontology,,DOID:2018,,,,,,,,,,,,,,,,,,,hyperinsulinism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2152,"[""ovary epithelial cancer""]",,An ovarian cancer that is derives_from ovarian surface epithelium.,false,,,http://purl.obolibrary.org/obo/DOID_2394,,,,,,,,An ovarian cancer that is derives_from ovarian surface epithelium.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2152,,,,NCI:C4381|UMLS_CUI:C0341823|SNOMEDCT_US_2016_03_01:237057005,epithelial tumor of ovary (disorder)|Ovarian Surface epithelial-Stromal tumor,,disease_ontology,epithelial tumor of ovary,DOID:2152,,,,,,,,,,,,,,,,,,,ovary epithelial cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200607,"[""OR4S1 gene""]",,"An olfactory receptor 4S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200607,,,,,,,,,,,,,,,,256148,OR4S1,,,,,,,,,,,OR4S1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001957,"[""MC3T3-E1 cell""]",,Mouse embryo/fetus calvaria fibroblasts; established from the calvaria of an embryo/fetus C57BL/6 mouse; described to differentiate to osteoblasts and to produce collagen.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001958|http://purl.obolibrary.org/obo/BTO_0002052,,,,,,,,Mouse embryo/fetus calvaria fibroblasts; established from the calvaria of an embryo/fetus C57BL/6 mouse; described to differentiate to osteoblasts and to produce collagen.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001957,,,,,,,BrendaTissueOBO,,BTO:0001957,,,,,,,,,,,,,,,,,,,MC3T3-E1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13922,"[""eosinophilic esophagitis""]",,An esophagitis characterized by inflammation involving eosinophils located_in esophagus.,false,,,http://purl.obolibrary.org/obo/DOID_11963,,,,,,,,An esophagitis characterized by inflammation involving eosinophils located_in esophagus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13922,,,,ICD9CM:530.13|OMIM:610247|ICD10CM:K20.0|ORDO:73247|NCI:C27105|SNOMEDCT_US_2016_03_01:235599003|OMIM:613412|UMLS_CUI:C0341106|MESH:D057765|EFO:0004232,,,disease_ontology,,DOID:13922,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,eosinophilic esophagitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001433,"[""mononuclear phagocyte""]",,"Any cell of the monocyte-macrophage lineage, including macrophages, monocytes, and their precursors in the monocytic series.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001044|http://purl.obolibrary.org/obo/BTO_0000878|http://purl.obolibrary.org/obo/BTO_0001441,,,,,,,,"Any cell of the monocyte-macrophage lineage, including macrophages, monocytes, and their precursors in the monocytic series.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001433,,,,,,,BrendaTissueOBO,,BTO:0001433,,,,,,,,,,,,,,,,,,,mononuclear phagocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000143,"[""substantia nigra""]",,The substantia nigra is located in the mesencephalon (mid brain) region of the brain. It is part of the basal ganglia.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The substantia nigra is located in the mesencephalon (mid brain) region of the brain. It is part of the basal ganglia.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000143,,,,,,,BrendaTissueOBO,,BTO:0000143,,,,,,,,,,,,,,,,,,,substantia nigra,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3907,"[""lung squamous cell carcinoma""]",,A non-small cell lung carcinoma that has_material_basis_in the squamous cell.,false,,,http://purl.obolibrary.org/obo/DOID_1749|http://purl.obolibrary.org/obo/DOID_3908,,,,,,,,A non-small cell lung carcinoma that has_material_basis_in the squamous cell.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3907,,,,UMLS_CUI:C0149782|SNOMEDCT_US_2016_03_01:254634000|NCI:C3493,Epidermoid cell carcinoma of the lung,,disease_ontology,squamous cell carcinoma of lung,DOID:3907,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,lung squamous cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000474,"[""allantois""]",,"A vascular fetal membrane of reptiles, birds, and mammals that is formed as a pouch from the hindgut and that in placental mammals is intimately associated with the chorion in formation of the placenta.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000473,,,,,,,,"A vascular fetal membrane of reptiles, birds, and mammals that is formed as a pouch from the hindgut and that in placental mammals is intimately associated with the chorion in formation of the placenta.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000474,,,,,,,BrendaTissueOBO,,BTO:0000474,,,,,,,,,,,,,,,,,,,allantois,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3770,"[""pulmonary fibrosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3082,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3770,,,,SNOMEDCT_US_2016_03_01:196121006|SNOMEDCT_US_2016_03_01:155613001|MESH:D011658|UMLS_CUI:C0034069|NCI:C26869|SNOMEDCT_US_2016_03_01:51615001,Fibrosis of lung,,disease_ontology,,DOID:3770,,,,,,,,,,,,,,,,,,,pulmonary fibrosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2975,"[""cystic kidney disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_557,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2975,,,,UMLS_CUI:C0022679|MESH:D052177,renal Cyst|KIDNEY CYST,,disease_ontology,,DOID:2975,,,,,,,,,,,,,,,,,,,cystic kidney disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200662,"[""OR6K3 gene""]",,"An olfactory receptor 6K3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6K3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200662,,,,,,,,,,,,,,,,391114,OR6K3,,,,,,,,,,,OR6K3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000285,"[""PHE80 in CDKL1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000285,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE80 in CDKL1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004630,"[""middle midgut""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004630,mgr,2010-04-14T09:45:07Z,,,,,BrendaTissueOBO,,BTO:0004630,,,,,,,,,,,,,,,,,,,middle midgut,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000169,"[""MET433 in KPCL""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000169,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET433 in KPCL,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100103,"[""Serine/threonine-protein kinase dclk2""]",,"serine/threonine-protein kinase dclk2 (DCAMKL2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase DCLK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N568] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300147,,,,,,,,"serine/threonine-protein kinase dclk2 (DCAMKL2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase DCLK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N568] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100103,,,,https://pharos.nih.gov/idg/targets/Q8N568,,,,,,,,,,,,,DCLK2,DCAMKL2|DCDC3B|DCK2,,Q8N568,,,,,,,,Serine/threonine-protein kinase dclk2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400185,"[""STE-UNIQUE family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400113,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400185,,,,,,,,,,,,,,,,,,,,,,,,,,,,STE-UNIQUE family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000157,"[""CXCL3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000157,,,,,,,,,,,,,,,,,,,,,,,,,,,,CXCL3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000408,"[""THR80 in STK36""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000408,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR80 in STK36,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003098,"[""scrotum""]",,"The pouch that contains the testes and their accessory organs. It is composed of skin, the tunica dartos, the spermatic, cremasteric, and infundibuliform fasciae, and the tunica vaginalis testis.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003097,,,,,,,,"The pouch that contains the testes and their accessory organs. It is composed of skin, the tunica dartos, the spermatic, cremasteric, and infundibuliform fasciae, and the tunica vaginalis testis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003098,,,,,,,BrendaTissueOBO,,BTO:0003098,,,,,,,,,,,,,,,,,,,scrotum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000365,"[""THR654 in DDR2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000365,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR654 in DDR2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300214,"[""CCK4 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300214,,,,,,,,,,,,,,,,,,,,,,,,,,,,CCK4 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100053,"[""C-c chemokine receptor type 1""]",,"A C-C chemokine receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32246] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300095,,,,,,,,"A C-C chemokine receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32246] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100053,,,,https://pharos.nih.gov/idg/targets/P32246,,,,,,,,,,,,,CCR1,CMKBR1|CMKR1|SCYAR1,,P32246,,,,,,,,C-c chemokine receptor type 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000277,"[""MK13 kinase domain""]",,Mitogen-activated protein kinase 13; MAPK13; MGC99536; p38d; p38delta; p38-delta; PRKM13; SAPK4,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase 13; MAPK13; MGC99536; p38d; p38delta; p38-delta; PRKM13; SAPK4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000277,,,,,,,,,,,,,,,,,,,200300,,,,,,,,,MK13 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400442,"[""B (Shab) subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400442,,,,,,,,,,,,,,,,,,,,,,,,,,,,B (Shab) subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000179,"[""GRK7 kinase domain""]",,G protein-coupled receptor kinase 7; GPRK7; GRK7,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,G protein-coupled receptor kinase 7; GPRK7; GRK7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000179,,,,,,,,,,,,,,,,,,,200182,,,,,,,,,GRK7 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003600,"[""M cell""]",,"A unique, relatively rare intestinal epithelial cell type specialized for transepithelial transport of macromolecules, particles, and microorganisms. M cells in many species, including humans can be identified by morphological features such as their flattened apical surfaces and intraepithelial pockets containing lymphoid cells.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A unique, relatively rare intestinal epithelial cell type specialized for transepithelial transport of macromolecules, particles, and microorganisms. M cells in many species, including humans can be identified by morphological features such as their flattened apical surfaces and intraepithelial pockets containing lymphoid cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003600,,,,,,,BrendaTissueOBO,M-cell,BTO:0003600,,,,,,,,,,,,,,,,,,,M cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100056,"[""Voltage-dependent calcium channel gamma-2 subunit""]",,"A voltage-dependent calcium channel gamma-2 subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y698] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300336,,,,,,,,"A voltage-dependent calcium channel gamma-2 subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y698] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100056,,,,https://pharos.nih.gov/idg/targets/Q9Y698,,,,,,,,,,,,,CACNG2,,,Q9Y698,,,,,,,,Voltage-dependent calcium channel gamma-2 subunit,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002678,"[""testicular vein""]",,Either of the testicular veins.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000234,,,,,,,,Either of the testicular veins.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002678,,,,,,,BrendaTissueOBO,vena tesicularis|spermatic vein,BTO:0002678,,,,,,,,,,,,,,,,,,,testicular vein,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391001,"[""AK1 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391014,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391001,,,,,,,,,,,,,,,,,,,,,,,,,,,,AK1 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200319,"[""TRPA1 gene""]",,"The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins.  The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400360,,,,,,,,"The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins.  The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200319,,,,,,,,,,,,,,,,8989,TRPA1,ANKTM1,,,,,,,,,,TRPA1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200272,"[""PANX2 gene""]",,"The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400365,,,,,,,,"The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200272,,,,,,,,,,,,,,,,56666,PANX2,,,,,,,,,,,PANX2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004051,"[""bipolar cell""]",,"A type of neuron which has two extensions. Bipolar cells are specialized sensory neurons for the transmission of special senses. As such, they are part of the sensory pathways for smell, sight, taste, hearing and vestibular functions.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001037,,,,,,,,"A type of neuron which has two extensions. Bipolar cells are specialized sensory neurons for the transmission of special senses. As such, they are part of the sensory pathways for smell, sight, taste, hearing and vestibular functions.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004051,,,,,,,BrendaTissueOBO,,BTO:0004051,,,,,,,,,,,,,,,,,,,bipolar cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14188,"[""frozen shoulder""]",,,false,,,http://purl.obolibrary.org/obo/DOID_65,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14188,,,,SNOMEDCT_US_2016_03_01:156658000|SNOMEDCT_US_2016_03_01:156664007|SNOMEDCT_US_2016_03_01:8753005|UMLS_CUI:C0311223|ICD9CM:726.0|MESH:D002062|ICD10CM:M75.0|SNOMEDCT_US_2016_03_01:268087008|SNOMEDCT_US_2016_03_01:399114005|SNOMEDCT_US_2016_03_01:202847004|SNOMEDCT_US_2016_03_01:202837002,"Adhesive capsulitis of shoulder|adhesions-capsulitis,shoulder",,disease_ontology,,DOID:14188,,,,,,,,,,,,,,,,,,,frozen shoulder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100097,"[""Cytochrome b-245 heavy chain""]",,"A cytochrome b-245 heavy chain that is encoded in the genome of human. [PRO:DNx, UniProtKB:P04839] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300346,,,,,,,,"A cytochrome b-245 heavy chain that is encoded in the genome of human. [PRO:DNx, UniProtKB:P04839] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100097,,,,https://pharos.nih.gov/idg/targets/P04839,,,,,,,,,,,,,CYBB,NOX2,,P04839,,,,,,,,Cytochrome b-245 heavy chain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000380,"[""THR687 in TYK2(JH2domain-pseudokinase)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000380,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR687 in TYK2(JH2domain-pseudokinase),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300468,"[""SCN3B family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300370,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300468,,,,,,,,,,,,,,,,,,,,,,,,,,,,SCN3B family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100177,"[""Calcium-activated potassium channel subunit beta-2""]",,"A calcium-activated potassium channel subunit beta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y691] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300439,,,,,,,,"A calcium-activated potassium channel subunit beta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y691] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100177,,,,https://pharos.nih.gov/idg/targets/Q9Y691,,,,,,,,,,,,,KCNMB2,,,Q9Y691,,,,,,,,Calcium-activated potassium channel subunit beta-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000071,"[""CDK11 kinase domain""]",,Cyclin-dependent kinase 19; bA346C16.3; CDC2L6; CDK11; CDK19; KIAA1028,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Cyclin-dependent kinase 19; bA346C16.3; CDC2L6; CDK11; CDK19; KIAA1028,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000071,,,,,,,,,,,,,,,,,,,200074,,,,,,,,,CDK11 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200756,"[""QRFPR gene""]",,"An orexigenic neuropeptide QRFP receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P65] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"An orexigenic neuropeptide QRFP receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P65] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200756,,,,,,,,,,,,,,,,84109,QRFPR,GPR103,,,,,,,,,,QRFPR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100775,"[""Succinate receptor 1""]",,"A succinate receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BXA5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A succinate receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BXA5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100775,,,,https://pharos.nih.gov/idg/targets/Q9BXA5,,,,,,,,,,,,,SUCNR1,GPR91,,Q9BXA5,,,,,,,,Succinate receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000817,"[""mammary gland""]",,"The specialized accessory gland of the skin of female mammals that secretes milk. In the human female, it is a compound tubuloalveolar gland composed of 15 to 25 lobes arranged radially about the nipple and separated by connective and adipose tissue, each lobe having its own excretory (lactiferous) duct opening on the nipple. The lobes are subdivided into lobules, with the alveolar ducts and alveoli being the secretory portion of the gland.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The specialized accessory gland of the skin of female mammals that secretes milk. In the human female, it is a compound tubuloalveolar gland composed of 15 to 25 lobes arranged radially about the nipple and separated by connective and adipose tissue, each lobe having its own excretory (lactiferous) duct opening on the nipple. The lobes are subdivided into lobules, with the alveolar ducts and alveoli being the secretory portion of the gland.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000817,,,,,,,BrendaTissueOBO,mamma|Brustdruese|lactiferous gland|glandula mammaria,BTO:0000817,,,,,,,,,,,,,,,,,,,mammary gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1496,"[""echinococcosis""]",,"A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus Echinococcus in the liver, lungs, spleen, brain, heart and kidneys.",false,,,http://purl.obolibrary.org/obo/DOID_883,,,,,,,,"A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus Echinococcus in the liver, lungs, spleen, brain, heart and kidneys.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1496,,,DOID:2783|DOID:12149,UMLS_CUI:C0013502|ICD9CM:122|SNOMEDCT_US_2016_03_01:154414008|ICD10CM:B67.90|SNOMEDCT_US_2016_03_01:187143006|MESH:D004443|NCI:C84682|ICD10CM:B67|SNOMEDCT_US_2016_03_01:74942003,"hepatic echinococcosis|echinococcal disease|hydatid disease|Echinococcosis, unspecified, of liver|hydatidosis|Liver echinococcus unspecified (disorder)|pulmonary echinococcosis|Echinococcosis, unspecified, of liver (disorder)|Echinococcosis of liver (disorder)",,disease_ontology,,DOID:1496,,,,,,,,,,,,,,,,,,,echinococcosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100327,"[""Transient receptor potential cation channel subfamily m member 2""]",,"A transient receptor potential cation channel subfamily M member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O94759] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300584,,,,,,,,"A transient receptor potential cation channel subfamily M member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O94759] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100327,,,,https://pharos.nih.gov/idg/targets/O94759,,,,,,,,,,,,,TRPM2,EREG1|KNP3|LTRPC2|TRPC7,,O94759,,,,,,,,Transient receptor potential cation channel subfamily m member 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100252,"[""Calcium uniporter protein, mitochondrial""]",,"A calcium uniporter protein, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NE86] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300361,,,,,,,,"A calcium uniporter protein, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NE86] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100252,,,,https://pharos.nih.gov/idg/targets/Q8NE86,,,,,,,,,,,,,MCU,C10orf42|CCDC109A,,Q8NE86,,,,,,,,"Calcium uniporter protein, mitochondrial",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100254,"[""Sodium leak channel non-selective protein""]",,"A sodium leak channel non-selective protein that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8IZF0] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300363,,,,,,,,"A sodium leak channel non-selective protein that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8IZF0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100254,,,,https://pharos.nih.gov/idg/targets/Q8IZF0,,,,,,,,,,,,,NALCN,VGCNL1,,Q8IZF0,,,,,,,,Sodium leak channel non-selective protein,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050632,"[""oculocutaneous albinism""]",,"An autosomal recessive disease characterized by abnormal pigmentation of the skin, hair and eyes.",false,,,http://purl.obolibrary.org/obo/DOID_0050737,,,,,,,,"An autosomal recessive disease characterized by abnormal pigmentation of the skin, hair and eyes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050632,,,,ORDO:55|OMIM:614473|OMIM:606574|OMIM:606952|OMIM:615312|OMIM:203290|OMIM:203200|OMIM:203100|ICD10CM:E70.3,,,disease_ontology,,DOID:0050632,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,oculocutaneous albinism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050634,"[""alopecia universalis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_987,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050634,,,,OMIM:203655,ALOPECIA UNIVERSALIS CONGENITA,,disease_ontology,,DOID:0050634,,,,,,,,,,,,,,,,,,,alopecia universalis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050630,"[""Aland Island eye disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5614,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050630,,,,OMIM:300600,FORSIUS-ERIKSSON TYPE OCULAR ALBINISM|Forsius-Eriksson syndrome,,disease_ontology,,DOID:0050630,,,,,,,,,,,,,,,,,,,Aland Island eye disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050633,"[""ocular albinism""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5614,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050633,,,,OMIM:300500,,,disease_ontology,,DOID:0050633,,,,,,,,,,,,,,,,,,,ocular albinism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050639,"[""primary cutaneous amyloidosis""]",,"An amyloidosis characterized by pruritus, skin scratching and by deposits of amyloid in the dermis.",false,,,http://purl.obolibrary.org/obo/DOID_9120,,,,,,,,"An amyloidosis characterized by pruritus, skin scratching and by deposits of amyloid in the dermis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050639,,,,ORDO:137807|OMIM:105250|OMIM:613955,familial primary localized cutaneous amyloidosis|PCA,,disease_ontology,,DOID:0050639,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,primary cutaneous amyloidosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000034,"[""LEU1157 in MET(Y1235D)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000034,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU1157 in MET(Y1235D),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200150,"[""FGFR2 gene""]",,"The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400158,,,,,,,,"The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200150,,,,,,,,,,,,,,,,2263,FGFR2,BEK|KGFR|KSAM,,,,,,,,,,FGFR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200563,"[""OR3A3 gene""]",,"An olfactory receptor 3A3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47888] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 3A3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47888] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200563,,,,,,,,,,,,,,,,8392,OR3A3,OR3A6|OR3A7|OR3A8P,,,,,,,,,,OR3A3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_824,"[""periodontitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3388,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:824,,,,EFO:0000649|SNOMEDCT_US_2016_03_01:155648008|SNOMEDCT_US_2016_03_01:266491004|SNOMEDCT_US_2016_03_01:41565005|NCI:C34918|UMLS_CUI:C0031099|ICD10CM:K05.3|MESH:D010518,chronic pericementitis,,disease_ontology,,DOID:824,,,,,,,,,,,,,,,,,,,periodontitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002552,"[""NCI-H1299 cell""]",,"Homo sapiens (human) lung carcinoma cell line, non-small cell lung cancer; derived from metastatic site: lymph node.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002553,,,,,,,,"Homo sapiens (human) lung carcinoma cell line, non-small cell lung cancer; derived from metastatic site: lymph node.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002552,,,,,,,BrendaTissueOBO,H1299 cell|H-1299 cell,BTO:0002552,,,,,,,,,,,,,,,,,,,NCI-H1299 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100279,"[""Polycystic kidney disease 2-like 2 protein""]",,"A polycystic kidney disease 2-like 2 protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZM6] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300367,,,,,,,,"A polycystic kidney disease 2-like 2 protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZM6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100279,,,,https://pharos.nih.gov/idg/targets/Q9NZM6,,,,,,,,,,,,,PKD2L2,,,Q9NZM6,,,,,,,,Polycystic kidney disease 2-like 2 protein,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100178,"[""Glucokinase""]",,"A glucokinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35557] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391017,,,,,,,,"A glucokinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35557] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100178,,,,https://pharos.nih.gov/idg/targets/P35557,,,,,,,,,,,,,GCK,,,P35557,,,,,,,,Glucokinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200246,"[""LRRC38 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200246,,,,,,,,,,,,,,,,,LRRC38,,,,,,,,,,,LRRC38 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200111,"[""FZD9 gene""]",,"A frizzled-9 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O00144] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400043,,,,,,,,"A frizzled-9 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O00144] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200111,,,,,,,,,,,,,,,,8326,FZD9,FZD3,,,,,,,,,,FZD9 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_308,"[""early myoclonic encephalopathy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0050702,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:308,,,,MESH:D004831|SNOMEDCT_US_2016_03_01:192992007|SNOMEDCT_US_2016_03_01:37356005|UMLS_CUI:C0014550|SNOMEDCT_US_2016_03_01:192847001,"Myoclonic seizure disorder|Epileptic seizures, myoclonic|Epileptic seizures - myoclonic (disorder)|myoclonia epileptica|Myoclonic seizure|myoclonic epilepsy",,disease_ontology,,DOID:308,,,,,,,,,,,,,,,,,,,early myoclonic encephalopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_303,"[""substance-related disorder""]",,"A disease of mental health involving the abuse or dependence on a substance that is ingested in order to produce a high, alter one's senses, or otherwise affect functioning.",false,,,http://purl.obolibrary.org/obo/DOID_150,,,,,,,,"A disease of mental health involving the abuse or dependence on a substance that is ingested in order to produce a high, alter one's senses, or otherwise affect functioning.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:303,,,,MESH:D019966|NCI:C92203|UMLS_CUI:C0236969,,,disease_ontology,,DOID:303,,,,,,,,,,,,,,,,,,,substance-related disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_302,"[""substance abuse""]",,A substance-related disorder that involves a maladaptive pattern of substance use leading to significant impairment in functioning.,false,,,http://purl.obolibrary.org/obo/DOID_303,,,,,,,,A substance-related disorder that involves a maladaptive pattern of substance use leading to significant impairment in functioning.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:302,,,,SNOMEDCT_US_2016_03_01:26416006|MESH:D019966|UMLS_CUI:C0013146|NCI:C16522,,,disease_ontology,,DOID:302,,,,,,,,,,,,,,,,,,,substance abuse,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_305,"[""carcinoma""]",,A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.,false,,,http://purl.obolibrary.org/obo/DOID_0050687,,,,,,,,A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:305,,,DOID:6570|DOID:2428,SNOMEDCT_US_2016_03_01:68453008|CSP:2000-1867|SNOMEDCT_US_2016_03_01:189549006|SNOMEDCT_US_2016_03_01:154433003|SNOMEDCT_US_2016_03_01:134207000|MESH:D002277|SNOMEDCT_US_2016_03_01:269513004|UMLS_CUI:C1368683|UMLS_CUI:C0553707|SNOMEDCT_US_2016_03_01:71298006|SNOMEDCT_US_2016_03_01:188083002|UMLS_CUI:C0007097|MESH:D009375|NCI:C3709|SNOMEDCT_US_2016_03_01:118285006|SNOMEDCT_US_2016_03_01:189546004|NCI:C2916|SNOMEDCT_US_2016_03_01:189559007,malignant Epithelioma|epithelioma,,disease_ontology,,DOID:305,http://purl.obolibrary.org/obo/doid#DO_cancer_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000134,"[""MET153 in ROCK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000134,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET153 in ROCK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000043,"[""LEU1196 in ALK(L1196M)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000043,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU1196 in ALK(L1196M),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200295,"[""OR10AD1 gene""]",,"An olfactory receptor 10AD1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10AD1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200295,,,,,,,,,,,,,,,,121275,OR10AD1,OR10AD1P,,,,,,,,,,OR10AD1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200073,"[""CRHR2 gene""]",,"A corticotropin-releasing factor receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13324] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400036,,,,,,,,"A corticotropin-releasing factor receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13324] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200073,,,,,,,,,,,,,,,,1395,CRHR2,CRF2R|CRH2R,,,,,,,,,,CRHR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000388,"[""THR702 in EPHA1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000388,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR702 in EPHA1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004103,"[""leaf primordium""]",,The first stage of leaf development; a small lateral protuburance formed by an apical shoot meristem that will expand to form a leaf.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0005525|http://purl.obolibrary.org/obo/BTO_0000713,,,,,,,,The first stage of leaf development; a small lateral protuburance formed by an apical shoot meristem that will expand to form a leaf.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004103,XPMUser,2011-02-24T10:17:00Z,,,,,BrendaTissueOBO,primordial leaf,BTO:0004103,,,,,,,,,,,,,,,,,,,leaf primordium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2339,"[""Crouzon syndrome""]",,A craniosynostosis that involves premature fusion of certain skull bones. This early fusion prevents the skull from growing normally and affects the shape of the head and face. The disease is associated with mutations in the FGFR2 gene.,false,,,http://purl.obolibrary.org/obo/DOID_2340,,,,,,,,A craniosynostosis that involves premature fusion of certain skull bones. This early fusion prevents the skull from growing normally and affects the shape of the head and face. The disease is associated with mutations in the FGFR2 gene.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2339,,,,OMIM:123500|MESH:D003394|ICD10CM:Q75.1|NCI:C84653|UMLS_CUI:C0010273|SNOMEDCT_US_2016_03_01:28861008,Craniofacial Dysostosis,,disease_ontology,Crouzon's disease,DOID:2339,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Crouzon syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004489,"[""OE-21 cell""]",,Esophageal cancer cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002817,,,,,,,,Esophageal cancer cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004489,Marion,2010-02-04T05:19:45Z,,,,,BrendaTissueOBO,OE21 cell,BTO:0004489,,,,,,,,,,,,,,,,,,,OE-21 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000809,"[""germ cell cancer cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000809,,,,,,,BrendaTissueOBO,germ cell tumor cell,BTO:0000809,,,,,,,,,,,,,,,,,,,germ cell cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100284,"[""Mitogen-activated protein kinase kinase kinase 2""]",,"mitogen-activated protein kinase kinase kinase 2 (M3K2)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase kinase kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y2U5] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300186,,,,,,,,"mitogen-activated protein kinase kinase kinase 2 (M3K2)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase kinase kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y2U5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100284,,,,https://pharos.nih.gov/idg/targets/Q9Y2U5,,,,,,,,,,,,,MAP3K2,MAPKKK2|MEKK2,,Q9Y2U5,,,,,,,,Mitogen-activated protein kinase kinase kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200261,"[""KSR2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400126,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200261,,,,,,,,,,,,,,,,283455,KSR2,,,,,,,,,,,KSR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100043,"[""B2 bradykinin receptor""]",,"A B2 bradykinin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30411] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300025,,,,,,,,"A B2 bradykinin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30411] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100043,,,,https://pharos.nih.gov/idg/targets/P30411,,,,,,,,,,,,,BDKRB2,BKR2,,P30411,,,,,,,,B2 bradykinin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200214,"[""GPR87 gene""]",,"A G-protein coupled receptor 87 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BY21] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400053,,,,,,,,"A G-protein coupled receptor 87 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BY21] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200214,,,,,,,,,,,,,,,,53836,GPR87,GPR95,,,,,,,,,,GPR87 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003037,"[""HT-22 cell""]",,Mouse hippocampal cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003036,,,,,,,,Mouse hippocampal cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003037,,,,,,,BrendaTissueOBO,HT22 cell,BTO:0003037,,,,,,,,,,,,,,,,,,,HT-22 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100632,"[""6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3""]",,"A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16875] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300325,,,,,,,,"A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16875] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100632,,,,https://pharos.nih.gov/idg/targets/Q16875,,,,,,,,,,,,,PFKFB3,,,Q16875,,,,,,,,"6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200466,"[""OPN4 gene""]",,"A melanopsin that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UHM6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A melanopsin that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UHM6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200466,,,,,,,,,,,,,,,,94233,OPN4,MOP,,,,,,,,,,OPN4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200458,"[""MST1R gene""]",,"This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript variants encoding different isoforms with different structural and biochemical properties have been described (PMID:8816464). [provided by RefSeq, Oct 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400190,,,,,,,,"This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript variants encoding different isoforms with different structural and biochemical properties have been described (PMID:8816464). [provided by RefSeq, Oct 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200458,,,,,,,,,,,,,,,,4486,MST1R,PTK8|RON,,,,,,,,,,MST1R gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000024,"[""abomasum""]",,The fourth compartment of the ruminant stomach that follows the omasum and has a true digestive function.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0000945|http://purl.obolibrary.org/obo/BTO_0001307,,,,,,,,The fourth compartment of the ruminant stomach that follows the omasum and has a true digestive function.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000024,,,,,,,BrendaTissueOBO,fourth stomach,BTO:0000024,,,,,,,,,,,,,,,,,,,abomasum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200245,"[""LPHN2 gene""]",,"A latrophilin-2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O95490] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400039,,,,,,,,"A latrophilin-2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O95490] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200245,,,,,,,,,,,,,,,,23266,LPHN2,KIAA0786|LEC1|LPHH1,,,,,,,,,,LPHN2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200062,"[""CACNG8 gene""]",,"The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. The mRNA for this gene is believed to initiate translation from a non-AUG (CUG) start codon. [provided by RefSeq, Dec 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400336,,,,,,,,"The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. The mRNA for this gene is believed to initiate translation from a non-AUG (CUG) start codon. [provided by RefSeq, Dec 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200062,,,,,,,,,,,,,,,,59283,CACNG8,CACNG6,,,,,,,,,,CACNG8 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001691,"[""spiral organ""]",,"The organ, resting on the basilar membrane in the cochlear duct, that contains the special sensory receptors for hearing; it consists of neuroepithelial hair cells and several types of supporting cells, including the inner and outer pillar cells, inner and outer phalangeal cells, border cells, and Hensen's cells.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The organ, resting on the basilar membrane in the cochlear duct, that contains the special sensory receptors for hearing; it consists of neuroepithelial hair cells and several types of supporting cells, including the inner and outer pillar cells, inner and outer phalangeal cells, border cells, and Hensen's cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001691,,,,,,,BrendaTissueOBO,organ of Corti|basilar papilla|Corti's organ|spiral organ of Corti|organum spirale,BTO:0001691,,,,,,,,,,,,,,,,,,,spiral organ,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100056,"[""T747-T751del and Silenced in EGFR(L747-T751del,Sins)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100056,,,,,,,,,,,,,,,,,,,,,,,,,,,,"T747-T751del and Silenced in EGFR(L747-T751del,Sins)",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100268,"[""Melatonin receptor type 1b""]",,"A melatonin receptor type 1B that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49286] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300065,,,,,,,,"A melatonin receptor type 1B that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49286] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100268,,,,https://pharos.nih.gov/idg/targets/P49286,,,,,,,,,,,,,MTNR1B,,,P49286,,,,,,,,Melatonin receptor type 1b,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100221,"[""Calcium/calmodulin-dependent protein kinase type ii subunit gamma""]",,"A calcium/calmodulin-dependent protein kinase type II subunit gamma that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13555] |calcium/calmodulin-dependent protein kinase type ii subunit gamma (CAMK2G)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300172,,,,,,,,"A calcium/calmodulin-dependent protein kinase type II subunit gamma that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13555] |calcium/calmodulin-dependent protein kinase type ii subunit gamma (CAMK2G)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100221,,,,https://pharos.nih.gov/idg/targets/Q13555,,,,,,,,,,,,,CAMK2G,CAMK|CAMK-II|CAMKG,,Q13555,,,,,,,,Calcium/calmodulin-dependent protein kinase type ii subunit gamma,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100695,"[""Olfactory receptor 8G2""]",,"An olfactory receptor 8G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15614] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 8G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15614] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100695,,,,https://pharos.nih.gov/idg/targets/Q6IF36,,,,,,,,,,,,,OR8G2,OR8G2P|OR8G4,,Q6IF36,,,,,,,,Olfactory receptor 8G2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400368,"[""SLC26A/SulP transporter family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400368,,,,,,,,,,,,,,,,,,,,,,,,,,,,SLC26A/SulP transporter family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100263,"[""Mas-related g-protein coupled receptor member x3""]",,"A mas-related G-protein coupled receptor X3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96LB0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300063,,,,,,,,"A mas-related G-protein coupled receptor X3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96LB0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100263,,,,https://pharos.nih.gov/idg/targets/Q96LB0,,,,,,,,,,,,,MRGPRX3,MRGX3|SNSR1|SNSR2,,Q96LB0,,,,,,,,Mas-related g-protein coupled receptor member x3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100763,"[""Sphingosine 1-phosphate receptor 1""]",,"A sphingosine 1-phosphate receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21453] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A sphingosine 1-phosphate receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21453] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100763,,,,https://pharos.nih.gov/idg/targets/P21453,,,,,,,,,,,,,S1PR1,CHEDG1|EDG1,,P21453,,,,,,,,Sphingosine 1-phosphate receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100416,"[""Olfactory receptor 52E2""]",,"An olfactory receptor 52E2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 52E2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100416,,,,https://pharos.nih.gov/idg/targets/Q8NGJ4,,,,,,,,,,,,,OR52E2,,,Q8NGJ4,,,,,,,,Olfactory receptor 52E2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3342,"[""bone inflammation disease""]",,A bone disease that results_in inflammation of the located_in bone.,false,,,http://purl.obolibrary.org/obo/DOID_0080001,,,,,,,,A bone disease that results_in inflammation of the located_in bone.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3342,,,,SNOMEDCT_US_2016_03_01:274144001|MESH:D010000|SNOMEDCT_US_2016_03_01:44462005|UMLS_CUI:C0029400|SNOMEDCT_US_2016_03_01:156780005|SNOMEDCT_US_2016_03_01:363172002,osteitis|Inflammatory disorder of bone|bone inflammatory disease,,disease_ontology,,DOID:3342,,,,,,,,,,,,,,,,,,,bone inflammation disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5515,"[""nasal cavity squamous cell carcinoma""]",,A nasal cavity carcinoma that has_material_basis_in squamous cells.,false,,,http://purl.obolibrary.org/obo/DOID_1749|http://purl.obolibrary.org/obo/DOID_4931,,,,,,,,A nasal cavity carcinoma that has_material_basis_in squamous cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5515,,,,NCI:C8192|UMLS_CUI:C0280333,squamous cell carcinoma of the nasal cavity,,disease_ontology,squamous cell carcinoma of nasal cavity,DOID:5515,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,nasal cavity squamous cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100097,"[""Citron rho-interacting kinase""]",,"citron rho-interacting kinase (CIT)  with  no mutation  in a nonphosphorylated state|A citron Rho-interacting kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14578] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300145,,,,,,,,"citron rho-interacting kinase (CIT)  with  no mutation  in a nonphosphorylated state|A citron Rho-interacting kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14578] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100097,,,,https://pharos.nih.gov/idg/targets/O14578,,,,,,,,,,,,,CIT,CRIK|KIAA0949|STK21,,O14578,,,,,,,,Citron rho-interacting kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200146,"[""FASTK gene""]",,"The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400156,,,,,,,,"The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200146,,,,,,,,,,,,,,,,10922,FASTK,,,,,,,,,,,FASTK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000187,"[""HIPK4 kinase domain""]",,Homeodomain interacting protein kinase 4; FLJ32818; HIPK4,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Homeodomain interacting protein kinase 4; FLJ32818; HIPK4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000187,,,,,,,,,,,,,,,,,,,200189,,,,,,,,,HIPK4 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004640,"[""FD-2 cell""]",,Farber disease dermal fibroblast cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001619,,,,,,,,Farber disease dermal fibroblast cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004640,XPMUser,2013-03-15T12:57:07Z,,,,,BrendaTissueOBO,GM20017 cell,BTO:0004640,,,,,,,,,,,,,,,,,,,FD-2 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000193,"[""MET652 in KPCD3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000193,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET652 in KPCD3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100155,"[""Inward rectifier potassium channel 16""]",,"An inward rectifier potassium channel 16 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NPI9] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300427,,,,,,,,"An inward rectifier potassium channel 16 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NPI9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100155,,,,https://pharos.nih.gov/idg/targets/Q9NPI9,,,,,,,,,,,,,KCNJ16,,,Q9NPI9,,,,,,,,Inward rectifier potassium channel 16,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9622,"[""kidney hypertrophy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_557,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9622,,,,ICD9CM:593.1|SNOMEDCT_US_2016_03_01:197800004|UMLS_CUI:C0156259|ICD10CM:N28.81|SNOMEDCT_US_2016_03_01:88531004|NCI:C122991,,,disease_ontology,,DOID:9622,,,,,,,,,,,,,,,,,,,kidney hypertrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100630,"[""Olfactory receptor 5K1""]",,"An olfactory receptor 5K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHB7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHB7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100630,,,,https://pharos.nih.gov/idg/targets/Q8NHB7,,,,,,,,,,,,,OR5K1,,,Q8NHB7,,,,,,,,Olfactory receptor 5K1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_63000007,"[""Pkinase_Tyr""]",,"A Pfam protein family that attaches phosphate groups to other amino acids (serine and threonine). Phosphorylation of proteins by kinases is an important mechanism in communicating signals within a cell (signal transduction) and regulating cellular activity, such as cell division.Tyrosine kinases are a subclass of protein kinase.",false,,,http://www.drugtargetontology.org/dto/DTO_63000006,,,,,,,,"A Pfam protein family that attaches phosphate groups to other amino acids (serine and threonine). Phosphorylation of proteins by kinases is an important mechanism in communicating signals within a cell (signal transduction) and regulating cellular activity, such as cell division.Tyrosine kinases are a subclass of protein kinase.","http://pfam.xfam.org/family/Pkinase_Tyr
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_63000007,,,,,,,,,,,,,,,,,,,,,,,,,,,,Pkinase_Tyr,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100217,"[""Potassium channel subfamily K member 5""]",,"A potassium channel subfamily K member 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95279] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300359,,,,,,,,"A potassium channel subfamily K member 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95279] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100217,,,,https://pharos.nih.gov/idg/targets/O95279,,,,,,,,,,,,,KCNK5,TASK2,,O95279,,,,,,,,Potassium channel subfamily K member 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200332,"[""OR11H4 gene""]",,"An olfactory receptor 11H4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 11H4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200332,,,,,,,,,,,,,,,,390442,OR11H4,,,,,,,,,,,OR11H4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491024,"[""Uridine kinase family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400322,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491024,,,,,,,,,,,,,,,,,,,,,,,,,,,,Uridine kinase family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13725,"[""beriberi""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5113,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13725,,,,ICD10CM:E51.1|ICD10CM:E51.11|UMLS_CUI:C0005122|SNOMEDCT_US_2016_03_01:36656008|NCI:C34418|SNOMEDCT_US_2016_03_01:267491008|ICD9CM:265.0|SNOMEDCT_US_2016_03_01:154725000|MESH:D001602|SNOMEDCT_US_2016_03_01:190625009|SNOMEDCT_US_2016_03_01:35843007,,,disease_ontology,,DOID:13725,,,,,,,,,,,,,,,,,,,beriberi,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000281,"[""PHE791 in CDC2L5""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000281,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE791 in CDC2L5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300404,"[""CNGA3 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300343,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300404,,,,,,,,,,,,,,,,,,,,,,,,,,,,CNGA3 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100106,"[""Discoidin domain-containing receptor 2""]",,"A discoidin domain-containing receptor 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q16832] |discoidin domain-containing receptor 2 (DDR2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300148,,,,,,,,"A discoidin domain-containing receptor 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q16832] |discoidin domain-containing receptor 2 (DDR2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100106,,,,https://pharos.nih.gov/idg/targets/Q16832,,,,,,,,,,,,,DDR2,NTRKR3|TKT|TYRO10,,Q16832,,,,,,,,Discoidin domain-containing receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100204,"[""Probable g-protein coupled receptor 62""]",,"A G-protein coupled receptor 62 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BZJ7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 62 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BZJ7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100204,,,,https://pharos.nih.gov/idg/targets/Q9BZJ7,,,,,,,,,,,,,GPR62,,,Q9BZJ7,,,,,,,,Probable g-protein coupled receptor 62,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200035,"[""ADRB3 gene""]",,"A beta-3 adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P13945] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400094,,,,,,,,"A beta-3 adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P13945] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200035,,,,,,,,,,,,,,,,155,ADRB3,ADRB3R|B3AR,,,,,,,,,,ADRB3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100112,"[""Gamma-aminobutyric acid receptor subunit alpha-6""]",,"A gamma-aminobutyric acid receptor subunit alpha-6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16445] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300511,,,,,,,,"A gamma-aminobutyric acid receptor subunit alpha-6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16445] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100112,,,,https://pharos.nih.gov/idg/targets/Q16445,,,,,,,,,,,,,GABRA6,,,Q16445,,,,,,,,Gamma-aminobutyric acid receptor subunit alpha-6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200282,"[""PLLP gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200282,,,,,,,,,,,,,,,,,PLLP,,,,,,,,,,,PLLP gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400044,"[""GPR137 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400044,,,,,,,,,,,,,,,,,,,,,,,,,,,,GPR137 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4606,"[""bile duct cancer""]",,A biliary tract cancer that is located_in the bile duct.,false,,,http://purl.obolibrary.org/obo/DOID_4138|http://purl.obolibrary.org/obo/DOID_4607,,,,,,,,A biliary tract cancer that is located_in the bile duct.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4606,,,DOID:10019,UMLS_CUI:C0153453|ICD10CM:C24.0|SNOMEDCT_US_2016_03_01:154473009|SNOMEDCT_US_2016_03_01:187787007|SNOMEDCT_US_2016_03_01:93790004|MESH:D001650|UMLS_CUI:C0005396|ICD9CM:156.1|NCI:C2898|NCI:C7483|SNOMEDCT_US_2016_03_01:363416002,bile duct tumor|Ca extrahepatic bile ducts|malignant neoplasm of the extrahepatic bile duct,,disease_ontology,,DOID:4606,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,bile duct cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200220,"[""CAMK2D gene""]",,"The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400172,,,,,,,,"The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200220,,,,,,,,,,,,,,,,817,CAMK2D,CAMKD,,,,,,,,,,CAMK2D gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000784,"[""lymph node""]",,"Any of the rounded masses of lymphoid tissue that are surrounded by a capsule of connective tissue, are distributed along the lymphatic vessels, and contain numerous lymphocytes which filter the flow of lymph.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001488|http://purl.obolibrary.org/obo/BTO_0000753,,,,,,,,"Any of the rounded masses of lymphoid tissue that are surrounded by a capsule of connective tissue, are distributed along the lymphatic vessels, and contain numerous lymphocytes which filter the flow of lymph.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000784,,,,,,,BrendaTissueOBO,lymph gland,BTO:0000784,,,,,,,,,,,,,,,,,,,lymph node,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001388,"[""trachea""]",,1: The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi. It is kept patent by a series of about twenty transverse horseshoe-shaped cartilages. Called also windpipe. 2: One of a system of minute tubes ramifying throughout the body of a terrestrial arthropod and delivering air to the tissues. Called also tracheal tubule.,false,,,http://purl.obolibrary.org/obo/BTO_0000203|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,1: The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi. It is kept patent by a series of about twenty transverse horseshoe-shaped cartilages. Called also windpipe. 2: One of a system of minute tubes ramifying throughout the body of a terrestrial arthropod and delivering air to the tissues. Called also tracheal tubule.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001388,,,,,,,BrendaTissueOBO,tracheal tubule|windpipe,BTO:0001388,,,,,,,,,,,,,,,,,,,trachea,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000174,"[""FYN kinase domain""]",,"FYN oncogene related to SRC, FGR, YES; FYN; MGC45350; SLK; SYN",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"FYN oncogene related to SRC, FGR, YES; FYN; MGC45350; SLK; SYN",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000174,,,,,,,,,,,,,,,,,,,200177,,,,,,,,,FYN kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000374,"[""PTK6 kinase domain""]",,Protein tyrosine kinase 6; BRK; FLJ42088; PTK6,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Protein tyrosine kinase 6; BRK; FLJ42088; PTK6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000374,,,,,,,,,,,,,,,,,,,200056,,,,,,,,,PTK6 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400104,"[""Other group gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400102,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,Other group gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100008,"[""D559 and I670 in KIT(V559D,T670I)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100008,,,,,,,,,,,,,,,,,,,,,,,,,,,,"D559 and I670 in KIT(V559D,T670I)",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001385,"[""tongue""]",,A fleshy movable process of the floor of the mouths of most vertebrates that bears sensory end organs and small glands and functions especially in taking and swallowing food and in humans as a speech organ.,false,,,http://purl.obolibrary.org/obo/BTO_0000202|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A fleshy movable process of the floor of the mouths of most vertebrates that bears sensory end organs and small glands and functions especially in taking and swallowing food and in humans as a speech organ.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001385,,,,,,,BrendaTissueOBO,,BTO:0001385,,,,,,,,,,,,,,,,,,,tongue,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000289,"[""PHE89 in HIPK4""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000289,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE89 in HIPK4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003629,"[""annulus fibrosus disci intervertebralis""]",,"The ring of fibrocartilage and fibrous tissue forming the circumference of the intervertebral disc; surrounds the nucleus pulposus, which is prone to herniation when the annulus fibrosus is compromised.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003627,,,,,,,,"The ring of fibrocartilage and fibrous tissue forming the circumference of the intervertebral disc; surrounds the nucleus pulposus, which is prone to herniation when the annulus fibrosus is compromised.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003629,,,,,,,BrendaTissueOBO,fibrous ring of intervertebral disc|annulus fibrosus of intervertebral disc,BTO:0003629,,,,,,,,,,,,,,,,,,,annulus fibrosus disci intervertebralis,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002904,"[""non-Hodgkin lymphoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002904,,,,,,,BrendaTissueOBO,non-Hodgkin's lymphoma cell line|non-Hodgkins lymphoma cell,BTO:0002904,,,,,,,,,,,,,,,,,,,non-Hodgkin lymphoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/UBERON_0002048,"[""lung""]",pulmo,"Respiration organ present in all air-breathing animals whose principal function is to transport oxygen from the atmosphere into the bloodstream, and to release carbon dioxide from the bloodstream into the atmosphere[WP]. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax[GO].",false,,,http://purl.obolibrary.org/obo/BTO_0000203|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,http://linkedlifedata.com/resource/umls/id/C0024109|http://en.wikipedia.org/wiki/Lung|http://www.snomedbrowser.com/Codes/Details/181216001|AAO:0000275|EHDAA:2205|VHOG:0000310|MESH:A04.411|EHDAA:1554|EV:0100042|OpenCyc:Mx4rvVjKy5wpEbGdrcN5Y29ycA|MA:0000415|EHDAA2:0001042|FMA:7195|MIAA:0000135|galen:Lung|BTO:0000763|ncithesaurus:Lung|MAT:0000135|AAO:0010567|CALOHA:TS-0568|GAID:345|UMLS:C0024109|XAO:0000119|EMAPA:16728|EFO:0000934,"Respiration organ present in all air-breathing animals whose principal function is to transport oxygen from the atmosphere into the bloodstream, and to release carbon dioxide from the bloodstream into the atmosphere[WP]. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax[GO].",,,,,,,,,,Either of two organs which allow gas exchange absorbing oxygen from inhaled air and releasing carbon dioxide with exhaled air.[AAO],,,,,,,,,,,,,,,,,,,,,,,,,,pulmo,,uberon,,pulmonary,"Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata. (...) In actinopterygian fishes, apart from Cladistia, the ventral intestinal pocket migrates dorsally and becomes the swim-bladder, a mainly hydrostatical organ (reference 1); Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and Mammalian lung (reference 2).[well established][VHOG]",,,,,,,,,,,,,,,,,,,,,,,,UBERON:0002048,,,"respiration organ in all air-breathing animals, including most tetrapods, a few fish and a few snails. In mammals and the more complex life forms, the two lungs are located in the chest on either side of the heart. Their principal function is to transport oxygen from the atmosphere into the bloodstream, and to release carbon dioxide from the bloodstream into the atmosphere. This exchange of gases is accomplished in the mosaic of specialized cells that form millions of tiny, exceptionally thin-walled air sacs called alveoli. // Avian lungs do not have alveoli as mammalian lungs do, they have Faveolar lungs. They contain millions of tiny passages known as para-bronchi, connected at both ends by the dorsobronchi // Snakes and limbless lizards typically possess only the right lung as a major respiratory organ; the left lung is greatly reduced, or even absent. Amphisbaenians, however, have the opposite arrangement, with a major left lung, and a reduced or absent right lung [WP]",,lung,,UBERON:0002048,,http://purl.obolibrary.org/obo/uberon.owl,http://purl.obolibrary.org/obo/uberon/core#efo_slim|http://purl.obolibrary.org/obo/uberon/core#organ_slim|http://purl.obolibrary.org/obo/uberon/core#major_organ|http://purl.obolibrary.org/obo/uberon/core#uberon_slim,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/UBERON_0002046,"[""thyroid gland""]",glandula thyroidea,"A two-lobed endocrine gland found in all vertebrates, located in front of and on either side of the trachea in humans, and producing various hormones, such as triiodothyronine and calcitonin[BTO].",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062|http://purl.obolibrary.org/obo/BTO_0001488,,,,,,,http://www.snomedbrowser.com/Codes/Details/181117000|http://en.wikipedia.org/wiki/Thyroid|http://linkedlifedata.com/resource/umls/id/C0040132|galen:ThyroidGland|MAT:0000081|EV:0100133|EMAPA:18827|MIAA:0000081|EMAPA:17068|MA:0000129|BTO:0001379|EFO:0000861|FMA:9603|XAO:0000162|EHDAA:2975|EHDAA:2148|EHDAA2:0002028|GAID:465|MESH:A06.407.900|AAO:0010544|CALOHA:TS-1047|UMLS:C0040132|OpenCyc:Mx4rvVjLT5wpEbGdrcN5Y29ycA|VHOG:0000418|ncithesaurus:Thyroid_Gland,"A two-lobed endocrine gland found in all vertebrates, located in front of and on either side of the trachea in humans, and producing various hormones, such as triiodothyronine and calcitonin[BTO].",,http://upload.wikimedia.org/wikipedia/commons/thumb/c/c6/Illu_endocrine_system.jpg/200px-Illu_endocrine_system.jpg|http://upload.wikimedia.org/wikipedia/commons/a/a3/Illu_thyroid_parathyroid.jpg,,,,,,,,Either of paired structures located in the throat which develop from the ventral wall of the pharynx and excretes hormones involved in the morphological and functional changes during metamorphosis as well as influencing other tissues.[AAO],,,,,,,,,,,,,,,,,,,,,,,,,,thyroid,,uberon,glandula thyroidea,," (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (2) a groove in the pharyngeal floor known as the endostyle, or a thyroid gland derived from part of the endostyle (...).[well established][VHOG]",,,,,,,,,,,,,,,,,,,,,,,,UBERON:0002046,,,,,thyroid gland,,UBERON:0002046,,http://purl.obolibrary.org/obo/uberon.owl,http://purl.obolibrary.org/obo/uberon/core#efo_slim|http://purl.obolibrary.org/obo/uberon/core#organ_slim|http://purl.obolibrary.org/obo/uberon/core#uberon_slim,,,,,,,,,,,,,,,,,,,,,,"In tetrapods, the thyroid is always found somewhere in the neck region. In most tetrapod species, there are two paired thyroid glands - that is, the right and left lobes are not joined together. However, there is only ever a single thyroid gland in most mammals, and the shape found in humans is common to many other species|In fish, it is usually located below the gills and is not always divided into distinct lobes. However, in some teleosts, patches of thyroid tissue are found elsewhere in the body, associated with the kidneys, spleen, heart, or eyes|In larval lampreys, the thyroid originates as an exocrine gland, secreting its hormones into the gut, and associated with the larva's filter-feeding apparatus. In the adult lamprey, the gland separates from the gut, and becomes endocrine, but this path of development may reflect the evolutionary origin of the thyroid. For instance, the closest living relatives of vertebrates, the tunicates and Amphioxus, have a structure very similar to that of larval lampreys, and this also secretes iodine-containing compounds (albeit not thyroxine)",,
http://purl.obolibrary.org/obo/DOID_0050524,"[""maturity-onset diabetes of the young""]",,A genetic disease that has_material_basis_in mutations in the MODY genes disrupting insulin production.,false,,,http://purl.obolibrary.org/obo/DOID_630,,,,,,,,A genetic disease that has_material_basis_in mutations in the MODY genes disrupting insulin production.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050524,,,,OMIM:606391|ICD10CM:E11.8|OMIM:616329|OMIM:613370|OMIM:612225|OMIM:610508|OMIM:606392|KEGG:04950|OMIM:616511|OMIM:125851|ORDO:552|OMIM:600496|OMIM:609812|OMIM:613375|OMIM:606394|OMIM:137920|OMIM:125850,MODY|Mason-type diabetes,,disease_ontology,,DOID:0050524,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,maturity-onset diabetes of the young,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001855,"[""venom duct""]",,"One of the paired, internal tubes leading from the venom glands to the paired openings near the tip of the aculeus.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"One of the paired, internal tubes leading from the venom glands to the paired openings near the tip of the aculeus.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001855,,,,,,,BrendaTissueOBO,,BTO:0001855,,,,,,,,,,,,,,,,,,,venom duct,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000320,"[""cyst""]",,A body resembling a cyst: as a 1: capsule formed about a minute organism going into a resting or spore stage; also: this capsule with its contents. 2: a resistant cover about a parasite produced by the parasite or the host.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000139|http://purl.obolibrary.org/obo/BTO_0000284,,,,,,,,A body resembling a cyst: as a 1: capsule formed about a minute organism going into a resting or spore stage; also: this capsule with its contents. 2: a resistant cover about a parasite produced by the parasite or the host.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000320,,,,,,,BrendaTissueOBO,,BTO:0000320,,,,,,,,,,,,,,,,,,,cyst,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13941,"[""benign paroxysmal positional nystagmus""]",,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",false,,,http://purl.obolibrary.org/obo/DOID_9847,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13941,,,,OMIM:193007|OMIM:613106|MESH:D065635|UMLS_CUI:C0155502|SNOMEDCT_US_2016_03_01:232285008|SNOMEDCT_US_2016_03_01:111541001|SNOMEDCT_US_2016_03_01:267763004|ICD9CM:386.11,benign paroxysmal positional vertigo,,disease_ontology,,DOID:13941,,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,benign paroxysmal positional nystagmus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13949,"[""interstitial cystitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1679,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13949,,,,SNOMEDCT_US_2016_03_01:111409009|MESH:D018856|UMLS_CUI:C0282488|NCI:C27189|SNOMEDCT_US_2016_03_01:197834003,ulcerative cystitis,,disease_ontology,,DOID:13949,,,,,,,,,,,,,,,,,,,interstitial cystitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_585,"[""nephrolithiasis""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_557,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:585,,,,SNOMEDCT_US_2016_03_01:197796005|SNOMEDCT_US_2016_03_01:266556005|EFO:0004253|SNOMEDCT_US_2016_03_01:266622009|OMIM:167030|SNOMEDCT_US_2016_03_01:197792007|ICD9CM:592|ICD10CM:N20|ICD10CM:N20.2|SNOMEDCT_US_2016_03_01:155867005|UMLS_CUI:C0156257,"kidney stones|calculus of kidney and ureter|NEPHROLITHIASIS, CALCIUM OXALATE|Stone - kidney/ureter|UROLITHIASIS, CALCIUM OXALATE",,disease_ontology,,DOID:585,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,nephrolithiasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_589,"[""congenital hemolytic anemia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_583,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:589,,,,SNOMEDCT_US_2016_03_01:42601008|ICD9CM:282.9|SNOMEDCT_US_2016_03_01:267558001|ICD9CM:282|SNOMEDCT_US_2016_03_01:154801000|NCI:C34379|UMLS_CUI:C0002881|MESH:D000745|ICD10CM:D58.9|SNOMEDCT_US_2016_03_01:267556002|SNOMEDCT_US_2016_03_01:38911009|SNOMEDCT_US_2016_03_01:191208008|SNOMEDCT_US_2016_03_01:154794008,hereditary hemolytic anemia,,disease_ontology,,DOID:589,,,,,,,,,,,,,,,,,,,congenital hemolytic anemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_583,"[""hemolytic anemia""]",,"OMIM mapping confirmed by DO. [SN].
OMIM mapping by NeuroDevNet. [LS].",false,,,http://purl.obolibrary.org/obo/DOID_720,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:583,,,,ICD10CM:D55-D59|NCI:C34376|SNOMEDCT_US_2016_03_01:191231008|SNOMEDCT_US_2016_03_01:61261009|OMIM:612631|MESH:D000743|OMIM:266120|SNOMEDCT_US_2016_03_01:191416001|UMLS_CUI:C0002878,ANEMIA HEMOLYTIC,,disease_ontology,,DOID:583,,,,,,,,,,,,,,,,,"OMIM mapping confirmed by DO. [SN].
OMIM mapping by NeuroDevNet. [LS].",,hemolytic anemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_580,"[""acute urate nephropathy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_557,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:580,,,,SNOMEDCT_US_2016_03_01:16410004|SNOMEDCT_US_2016_03_01:267441009|NCI:C123245|ICD9CM:274.11|NCI:C123037|SNOMEDCT_US_2016_03_01:190831009|UMLS_CUI:C0403719|SNOMEDCT_US_2016_03_01:197793002,Uric acid nephrolithiasis|Uric acid urolithiasis,,disease_ontology,,DOID:580,,,,,,,,,,,,,,,,,,,acute urate nephropathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000617,"[""TSH""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000617,,,,,,,,,,,,,,,,,,,,,,,,,,,,TSH,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000870,"[""spinal nerve""]",,"Any of the paired nerves which leave the spinal cord of a craniate vertebrate, supply muscles of the trunk and limbs, and connect with the nerves of the sympathetic nervous system, which arise by a short motor ventral root and a short sensory dorsal root, and of which there are 31 pairs in humans classified according to the part of the spinal cord from which they arise into 8 cervical pairs, 12 thoracic pairs, 5 lumbar pairs, 5 sacral pairs, and one coccygeal pair.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000925,,,,,,,,"Any of the paired nerves which leave the spinal cord of a craniate vertebrate, supply muscles of the trunk and limbs, and connect with the nerves of the sympathetic nervous system, which arise by a short motor ventral root and a short sensory dorsal root, and of which there are 31 pairs in humans classified according to the part of the spinal cord from which they arise into 8 cervical pairs, 12 thoracic pairs, 5 lumbar pairs, 5 sacral pairs, and one coccygeal pair.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000870,,,,,,,BrendaTissueOBO,,BTO:0000870,,,,,,,,,,,,,,,,,,,spinal nerve,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002158,"[""huelle cell""]",,"A cell having a thickened cell wall and a small lumen. Hulle cells are associated with species of Aspergillus. They are associated with the cleistothecia of all ascogenous species of the Aspergillus nidulans group, abundantly occurring around it.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A cell having a thickened cell wall and a small lumen. Hulle cells are associated with species of Aspergillus. They are associated with the cleistothecia of all ascogenous species of the Aspergillus nidulans group, abundantly occurring around it.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002158,,,,,,,BrendaTissueOBO,hulle cell,BTO:0002158,,,,,,,,,,,,,,,,,,,huelle cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100734,"[""P2Y purinoceptor 13""]",,"A P2Y purinoceptor 13 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BPV8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300100,,,,,,,,"A P2Y purinoceptor 13 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BPV8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100734,,,,https://pharos.nih.gov/idg/targets/Q9BPV8,,,,,,,,,,,,,P2RY13,GPR86|GPR94,,Q9BPV8,,,,,,,,P2Y purinoceptor 13,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000320,"[""THR301 in WNK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000320,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR301 in WNK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000112,"[""MET126 in PRKX""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000112,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET126 in PRKX,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400363,"[""Cation-nonselective channel family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400363,,,,,,,,,,,,,,,,,,,,,,,,,,,,Cation-nonselective channel family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100356,"[""Olfactory receptor 14k1""]",,"An olfactory receptor 14K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 14K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100356,,,,https://pharos.nih.gov/idg/targets/Q8NGZ2,,,,,,,,,,,,,OR14K1,OR5AY1,,Q8NGZ2,,,,,,,,Olfactory receptor 14k1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002322,"[""cell property""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000284,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002322,,,,,,,BrendaTissueOBO,,BTO:0002322,,,,,,,,,,,,,,,,,,,cell property,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200049,"[""CALCRL gene""]",,"A calcitonin gene-related peptide type 1 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16602] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400028,,,,,,,,"A calcitonin gene-related peptide type 1 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16602] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200049,,,,,,,,,,,,,,,,10203,CALCRL,CGRPR,,,,,,,,,,CALCRL gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4184,"[""pseudohypoparathyroidism""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_896,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4184,,,,OMIM:603233|NCI:C99027|SNOMEDCT_US_2016_03_01:267479004|MESH:D011547|SNOMEDCT_US_2016_03_01:58976002|SNOMEDCT_US_2016_03_01:190867002|OMIM:612462|SNOMEDCT_US_2016_03_01:154697005|UMLS_CUI:C0033806|ICD10CM:E20.1,,,disease_ontology,,DOID:4184,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,pseudohypoparathyroidism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1829,"[""urethral stricture""]",,,false,,,http://purl.obolibrary.org/obo/DOID_12577,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1829,,,,ICD9CM:598.8|UMLS_CUI:C0029752,,,disease_ontology,,DOID:1829,,,,,,,,,,,,,,,,,,,urethral stricture,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100401,"[""Pyridoxal kinase""]",,"A pyridoxal kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00764] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391011,,,,,,,,"A pyridoxal kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00764] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100401,,,,https://pharos.nih.gov/idg/targets/O00764,,,,,,,,,,,,,PDXK,C21orf124|C21orf97|PKH|PNK,,O00764,,,,,,,,Pyridoxal kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001177,"[""retinal pigment epithelium""]",,"The pigment cell layer that nourishes the retinal cells, located just outside the retina and attached to the choroid.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000416,,,,,,,,"The pigment cell layer that nourishes the retinal cells, located just outside the retina and attached to the choroid.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001177,,,,,,,BrendaTissueOBO,"epithelium, retinal pigment",BTO:0001177,,,,,,,,,,,,,,,,,,,retinal pigment epithelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000871,"[""RAG cell""]",,"Mouse, BALB/cd, kidney, adenocarcinoma cell line. Derived from the original Renal-2a BALB/cd renal adenocarcinoma. Cells produce the unique kidney specific esterase ES-2 and have been used in somatic cell hybridisation studies because of their azaguanine resistant properties.",false,,,http://purl.obolibrary.org/obo/BTO_0000167|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000383,,,,,,,,"Mouse, BALB/cd, kidney, adenocarcinoma cell line. Derived from the original Renal-2a BALB/cd renal adenocarcinoma. Cells produce the unique kidney specific esterase ES-2 and have been used in somatic cell hybridisation studies because of their azaguanine resistant properties.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000871,,,,,,,BrendaTissueOBO,,BTO:0000871,,,,,,,,,,,,,,,,,,,RAG cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217463,"[""Rev-erb receptors gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00200002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217463,,,,,,,,,,,,,,,,,,,,,,,,,,,,Rev-erb receptors gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100566,"[""Wee1-like protein kinase 2""]",,"A wee1-like protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C1S8] |Wee1-like protein kinase 2 (WEE2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300212,,,,,,,,"A wee1-like protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C1S8] |Wee1-like protein kinase 2 (WEE2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100566,,,,https://pharos.nih.gov/idg/targets/P0C1S8,,,,,,,,,,,,,WEE2,WEE1B,,P0C1S8,,,,,,,,Wee1-like protein kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200289,"[""OR10A3 gene""]",,"An olfactory receptor 10A3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58181] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10A3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58181] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200289,,,,,,,,,,,,,,,,26496,OR10A3,,,,,,,,,,,OR10A3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300351,"[""Glutamate-gated ion channel  (GIC) Family of Neurotransmitter Receptors""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300351,,,,,,,,,,,,,,,,,,,,,,,,,,,,Glutamate-gated ion channel  (GIC) Family of Neurotransmitter Receptors,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000426,"[""VAL804 in RET""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000426,,,,,,,,,,,,,,,,,,,,,,,,,,,,VAL804 in RET,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001061,"[""PC-3 cell""]",,"Human prostate carcinoma cell line; established from the bone marrow metastasis isolated post-mortem from a 62-year-old Caucasian man with grade IV prostate cancer, poorly differentiated adenocarcinoma, after androgen suppression therapy; described to form tumors in nude mice, to grow in soft agar, and to be unresponsive to androgen treatment.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001033,,,,,,,,"Human prostate carcinoma cell line; established from the bone marrow metastasis isolated post-mortem from a 62-year-old Caucasian man with grade IV prostate cancer, poorly differentiated adenocarcinoma, after androgen suppression therapy; described to form tumors in nude mice, to grow in soft agar, and to be unresponsive to androgen treatment.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001061,,,,,,,BrendaTissueOBO,PC3 cell,BTO:0001061,,,,,,,,,,,,,,,,,,,PC-3 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001308,"[""gastric mucosa""]",,The mucous coat of the stomach.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000886,,,,,,,,The mucous coat of the stomach.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001308,,,,,,,BrendaTissueOBO,Magenschleimhaut|tunica mucosa gastris|stomach mucosa,BTO:0001308,,,,,,,,,,,,,,,,,,,gastric mucosa,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100415,"[""Olfactory receptor 52E1""]",,"An olfactory receptor 52E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 52E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100415,,,,https://pharos.nih.gov/idg/targets/Q8NGJ3,,,,,,,,,,,,,OR52E1,OR52E1P,,Q8NGJ3,,,,,,,,Olfactory receptor 52E1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117508,"[""Coup transcription factor 1""]",,"A COUP transcription factor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10589] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117471,,,,,,,,"A COUP transcription factor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10589] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117508,,,,https://pharos.nih.gov/idg/targets/P10589,,,,,,,,,,,,,NR2F1,ERBAL3,,P10589,,,,,,,,Coup transcription factor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117483,"[""Retinoic acid receptor beta""]",,"A retinoic acid receptor beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10826] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117461,,,,,,,,"A retinoic acid receptor beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10826] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117483,,,,https://pharos.nih.gov/idg/targets/P10826,,,,,,,,,,,,,RARB,NR1B2,,P10826,,,,,,,,Retinoic acid receptor beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000008,"[""ABL1(F317I)-phosphorylated kinase domain""]",,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",false,,,http://www.drugtargetontology.org/dto/DTO_61000006,,,,,,,,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000008,,,,,,,,,,,,,,,,,,,200007,,,,,,,,,ABL1(F317I)-phosphorylated kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200510,"[""STRADB gene""]",,"This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400187,,,,,,,,"This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200510,,,,,,,,,,,,,,,,55437,STRADB,ALS2CR2|ILPIP,,,,,,,,,,STRADB gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005561,"[""C9-MEF cell""]",,"Mouse embryonic fibroblast cell line oncogenically transformed with both E1A and ras, and containing p53-/-.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002572,,,,,,,,"Mouse embryonic fibroblast cell line oncogenically transformed with both E1A and ras, and containing p53-/-.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005561,Marion,2014-02-26T15:53:01Z,,,,,BrendaTissueOBO,C9 cell,BTO:0005561,,,,,,,,,,,,,,,,,,,C9-MEF cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001631,"[""leiomyosarcoma cell""]",,"A malignant tumor cell of smooth muscle origin. Smooth muscle is the major structural component of most hollow internal organs and the walls of blood vessels. Can occur almost anywhere in the body but is most frequent in the uterus and gastrointestinal tract. Complete surgical excision, if possible, is the treatment of choice.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001207,,,,,,,,"A malignant tumor cell of smooth muscle origin. Smooth muscle is the major structural component of most hollow internal organs and the walls of blood vessels. Can occur almost anywhere in the body but is most frequent in the uterus and gastrointestinal tract. Complete surgical excision, if possible, is the treatment of choice.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001631,,,,,,,BrendaTissueOBO,,BTO:0001631,,,,,,,,,,,,,,,,,,,leiomyosarcoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400423,"[""KCNJ12 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400423,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ12 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004738,"[""CFPAC-1 cell""]",,This line was derived from a pancreatic duct adenocarcinoma (liver metastasis) from a patient with cystic fibrosis.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003883,,,,,,,,This line was derived from a pancreatic duct adenocarcinoma (liver metastasis) from a patient with cystic fibrosis.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004738,mgr,2010-09-29T08:55:53Z,,,,,BrendaTissueOBO,CFPAC1 cell|CF-PAC-1 cell|CFPAC cell,BTO:0004738,,,,,,,,,,,,,,,,,,,CFPAC-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001484,"[""nervous system""]",,"The nervous system is essentially a biological information highway, and is responsible for controlling all the biological processes and movement in the body, and can also receive information and interpret it via electrical signals which are used in this nervous system. It consists of the Central Nervous System (CNS), essentially the processing area and the Peripheral Nervous System which detects and sends electrical impulses that are used in the nervous system.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,,"The nervous system is essentially a biological information highway, and is responsible for controlling all the biological processes and movement in the body, and can also receive information and interpret it via electrical signals which are used in this nervous system. It consists of the Central Nervous System (CNS), essentially the processing area and the Peripheral Nervous System which detects and sends electrical impulses that are used in the nervous system.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001484,,,,,,,BrendaTissueOBO,Nervensystem,BTO:0001484,,,,,,,,,,,,,,,,,,,nervous system,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200033,"[""BEST4 gene""]",,"This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The bestrophin 4 gene is predominantly expressed in the colon. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400331,,,,,,,,"This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The bestrophin 4 gene is predominantly expressed in the colon. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200033,,,,,,,,,,,,,,,,266675,BEST4,VMD2L2,,,,,,,,,,BEST4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400227,"[""YANK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400227,,,,,,,,,,,,,,,,,,,,,,,,,,,,YANK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050889,"[""non-syndromic intellectual disability""]",,An intellectual disability that is characterized by the absence of associated medical and behavioral signs and symptoms.,false,,,http://purl.obolibrary.org/obo/DOID_1059,,,,,,,,An intellectual disability that is characterized by the absence of associated medical and behavioral signs and symptoms.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050889,lschriml,2014-08-14T10:57:36Z,,OMIM:614202|OMIM:613192,,,disease_ontology,,DOID:0050889,,,,,,,,,,,,,,,,,,,non-syndromic intellectual disability,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050880,"[""Koolen de Vries syndrome""]",,"A syndrome that is characterized by developmental delay, intellectual disability, muscle weakness (hypotonia), epilepsy, distinctive facial features and congenital malformations of the heart, urogenital tract and the central nervous system, and has_physical_basis_in either a chromosome 17 (17q21.31) microdeletion or a mutation in the KANSL1-gene.",false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,"A syndrome that is characterized by developmental delay, intellectual disability, muscle weakness (hypotonia), epilepsy, distinctive facial features and congenital malformations of the heart, urogenital tract and the central nervous system, and has_physical_basis_in either a chromosome 17 (17q21.31) microdeletion or a mutation in the KANSL1-gene.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050880,lschriml,2014-08-06T12:57:12Z,,ORDO:96169|OMIM:610443,Koolen-De Vries syndrome|KANSL1-related intellectual disability syndrome|KdVS|17q21.31 microdeletion syndrome,,disease_ontology,,DOID:0050880,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,Koolen de Vries syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050888,"[""syndromic intellectual disability""]",,An intellectual disability that is characterized by the presence of associated medical and behavioral sign and symptoms.,false,,,http://purl.obolibrary.org/obo/DOID_1059,,,,,,,,An intellectual disability that is characterized by the presence of associated medical and behavioral sign and symptoms.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050888,lschriml,2014-08-14T10:55:32Z,,OMIM:300486|OMIM:300860|OMIM:309583,,,disease_ontology,,DOID:0050888,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,syndromic intellectual disability,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050882,"[""spinocerebellar ataxia type 5""]",,"An autosomal dominant cerebellar ataxia that is characterized by the early-onset of cerebellar signs and eye movement abnormalities with a very slow disease progression, and has material basis in mutation in the SPTBN2 gene.",false,,,http://purl.obolibrary.org/obo/DOID_1441,,,,,,,,"An autosomal dominant cerebellar ataxia that is characterized by the early-onset of cerebellar signs and eye movement abnormalities with a very slow disease progression, and has material basis in mutation in the SPTBN2 gene.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050882,lschriml,2014-08-06T03:51:03Z,,OMIM:600224,,,disease_ontology,,DOID:0050882,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,spinocerebellar ataxia type 5,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100700,"[""Olfactory receptor 8I2""]",,"An olfactory receptor 8I2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N0Y5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 8I2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N0Y5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100700,,,,https://pharos.nih.gov/idg/targets/Q8N0Y5,,,,,,,,,,,,,OR8I2,,,Q8N0Y5,,,,,,,,Olfactory receptor 8I2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300223,"[""RSKR family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300223,,,,,,,,,,,,,,,,,,,,,,,,,,,,RSKR family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100499,"[""Olfactory receptor 1l6""]",,"An olfactory receptor 1L6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1L6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100499,,,,https://pharos.nih.gov/idg/targets/Q8NGR2,,,,,,,,,,,,,OR1L6,OR1L7,,Q8NGR2,,,,,,,,Olfactory receptor 1l6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001973,"[""vascular endothelial cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0001519|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001973,,,,,,,BrendaTissueOBO,,BTO:0001973,,,,,,,,,,,,,,,,,,,vascular endothelial cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4844,"[""benign ependymoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060101,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4844,,,,NCI:C3017|SNOMEDCT_US_2016_03_01:443643007|SNOMEDCT_US_2016_03_01:57706008|UMLS_CUI:C0014474|SNOMEDCT_US_2016_03_01:189913004|MESH:D004806|SNOMEDCT_US_2016_03_01:253066003,epithelial ependymoma|WHO grade II Ependymal tumor,,disease_ontology,,DOID:4844,,,,,,,,,,,,,,,,,,,benign ependymoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100800,"[""Thromboxane A2 receptor""]",,"A thromboxane A2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21731] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A thromboxane A2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21731] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100800,,,,https://pharos.nih.gov/idg/targets/P21731,,,,,,,,,,,,,TBXA2R,,,P21731,,,,,,,,Thromboxane A2 receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000133,"[""EPHA1 kinase domain""]",,EPH receptor A1; EPH; EPHA1; EPHT; EPHT1; MGC163163,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,EPH receptor A1; EPH; EPHA1; EPHT; EPHT1; MGC163163,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000133,,,,,,,,,,,,,,,,,,,200135,,,,,,,,,EPHA1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200389,"[""OR51B5 gene""]",,"An olfactory receptor 51B5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H339] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 51B5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H339] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200389,,,,,,,,,,,,,,,,282763,OR51B5,,,,,,,,,,,OR51B5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000201,"[""pheochromocytoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000201,,,,,,,BrendaTissueOBO,,BTO:0000201,,,,,,,,,,,,,,,,,,,pheochromocytoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200200,"[""KCNF1 gene""]",,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily F. This gene is intronless and expressed in all tissues tested, including the heart, skeletal muscle, brain, kidney, and pancreas. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400548,,,,,,,,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily F. This gene is intronless and expressed in all tissues tested, including the heart, skeletal muscle, brain, kidney, and pancreas. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200200,,,,,,,,,,,,,,,,3754,KCNF1,,,,,,,,,,,KCNF1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004692,"[""venous system""]",,A system of interconnected blood vessels that returns blood to the heart from the tissue and capillary bed through progressively larger vessels.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001085,,,,,,,,A system of interconnected blood vessels that returns blood to the heart from the tissue and capillary bed through progressively larger vessels.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004692,mgr,2010-05-14T10:46:00Z,,,,,BrendaTissueOBO,,BTO:0004692,,,,,,,,,,,,,,,,,,,venous system,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001516,"[""BA/F3 cell""]",,Mouse pro B cell line. IL-3 dependent murine pro B cell line established from peripheral blood; apparently derived from BALB/c mouse.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000743,,,,,,,,Mouse pro B cell line. IL-3 dependent murine pro B cell line established from peripheral blood; apparently derived from BALB/c mouse.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001516,,,,,,,BrendaTissueOBO,,BTO:0001516,,,,,,,,,,,,,,,,,,,BA/F3 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100135,"[""Adhesion G protein-coupled receptor F5""]",,"A G-protein coupled receptor 116 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,"A G-protein coupled receptor 116 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100135,,,,https://pharos.nih.gov/idg/targets/Q8IZF2,,,,,,,,,,,,,GPR116,ADGRF5|KIAA0758,,Q8IZF2,,,,,,,,Adhesion G protein-coupled receptor F5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200228,"[""HCAR2 gene""]",,"A hydroxycarboxylic acid receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDS4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400060,,,,,,,,"A hydroxycarboxylic acid receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDS4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200228,,,,,,,,,,,,,,,,338442,HCAR2,GPR109A|HCA2|HM74A|NIACR1,,,,,,,,,,HCAR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100719,"[""Olfactory receptor 9Q1""]",,"An olfactory receptor 9Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 9Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100719,,,,https://pharos.nih.gov/idg/targets/Q8NGQ5,,,,,,,,,,,,,OR9Q1,,,Q8NGQ5,,,,,,,,Olfactory receptor 9Q1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000377,"[""RET(M918T) kinase domain""]",,Proto-oncogene tyrosine-protein kinase receptor Ret; CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET; RET51; RET-ELE1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Proto-oncogene tyrosine-protein kinase receptor Ret; CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET; RET51; RET-ELE1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000377,,,,,,,,,,,,,,,,,,,200371,,,,,,,,,RET(M918T) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3541,"[""cerebral ventricle cancer""]",,A cerebrum cancer that is located_in the cerebral ventricles.,false,,,http://purl.obolibrary.org/obo/DOID_368,,,,,,,,A cerebrum cancer that is located_in the cerebral ventricles.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3541,,,DOID:10856,ICD9CM:191.5|UMLS_CUI:C0007798|UMLS_CUI:C0346906|MESH:D002551|SNOMEDCT_US_2016_03_01:93748005|NCI:C2937|SNOMEDCT_US_2016_03_01:363471001|SNOMEDCT_US_2016_03_01:126958000|ICD10CM:C71.5|SNOMEDCT_US_2016_03_01:188294008,cerebral ventricle neoplasm|Intraventricular tumor of brain,,disease_ontology,,DOID:3541,,,,,,,,,,,,,,,,,,,cerebral ventricle cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2498,"[""tooth erosion""]",,,false,,,http://purl.obolibrary.org/obo/DOID_214,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2498,,,DOID:11509|DOID:12687,ICD9CM:521.35|UMLS_CUI:C0040436|ICD9CM:521.3|SNOMEDCT_US_2016_03_01:82212003|UMLS_CUI:C1456165|SNOMEDCT_US_2016_03_01:155634008|ICD9CM:521.34|SNOMEDCT_US_2016_03_01:196315004|ICD10CM:K03.2|MESH:D014077|SNOMEDCT_US_2016_03_01:266486000|UMLS_CUI:C1456164,localized erosion|generalized erosion,,disease_ontology,,DOID:2498,,,,,,,,,,,,,,,,,,,tooth erosion,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003100,"[""external female genital organ""]",,"The external genitalia of the female, comprising the pudendum femininum, clitoris, and urethra.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The external genitalia of the female, comprising the pudendum femininum, clitoris, and urethra.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003100,,,,,,,BrendaTissueOBO,organa genitalia feminina externa,BTO:0003100,,,,,,,,,,,,,,,,,,,external female genital organ,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100184,"[""Integrin-linked protein kinase""]",,An integrin-linked protein kinase that is encoded in the genome of human. ,false,,,http://www.drugtargetontology.org/dto/DTO_03300274,,,,,,,,An integrin-linked protein kinase that is encoded in the genome of human. ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100184,,,,https://pharos.nih.gov/idg/targets/Q13418,,,,,,,,,,,,,ILK,ILK1|ILK2,,Q13418,,,,,,,,Integrin-linked protein kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000158,"[""Aspirin triggered lipoxin A4""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000158,,,,,,,,,,,,,,,,,,,,,,,,,,,,Aspirin triggered lipoxin A4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300431,"[""KCNJ4 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300431,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ4 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200137,"[""EPHB4 gene""]",,"Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400153,,,,,,,,"Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200137,,,,,,,,,,,,,,,,2050,EPHB4,HTK|MYK1|TYRO11,,,,,,,,,,EPHB4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000000,"[""kinase domain""]",,A structurally conserved protein domain containing the catalytic function of the kinase.,false,,,http://www.w3.org/2002/07/owl#Thing,,,,,,,,A structurally conserved protein domain containing the catalytic function of the kinase.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000000,,,,,,,,,,,,,,,,,,,,,,,,,,,https://en.wikipedia.org/wiki/Protein_kinase_domain,kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000307,"[""NDR1 kinase domain""]",,Serine/threonine kinase 38; NDR; NDR1; STK38,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine kinase 38; NDR; NDR1; STK38,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000307,,,,,,,,,,,,,,,,,,,200284,,,,,,,,,NDR1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5485,"[""synovial sarcoma""]",,A synovium cancer which develops in the synovial membrane of the joints.,false,,,http://purl.obolibrary.org/obo/DOID_2706,,,,,,,,A synovium cancer which develops in the synovial membrane of the joints.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5485,,,,SNOMEDCT_US_2016_03_01:63211008|NCI:C3400|SNOMEDCT_US_2016_03_01:302851001|UMLS_CUI:C0039101|OMIM:300813|MESH:D013584,,,disease_ontology,,DOID:5485,,,,,,,,,,,,,,,,,Xref MGI.,,synovial sarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9282,"[""ocular hypertension""]",,An eye disease that is characterized by elevated intraocular pressure in the absence of optic nerve damage or visual field loss.,false,,,http://purl.obolibrary.org/obo/DOID_5614,,,,,,,,An eye disease that is characterized by elevated intraocular pressure in the absence of optic nerve damage or visual field loss.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9282,,,,SNOMEDCT_US_2016_03_01:267721003|SNOMEDCT_US_2016_03_01:155121008|SNOMEDCT_US_2016_03_01:193536008|UMLS_CUI:C0028840|ICD9CM:365.04|NCI:C3285|ICD10CM:H40.05|MESH:D009798|SNOMEDCT_US_2016_03_01:4210003,,,disease_ontology,,DOID:9282,,,,,,,,,,,,,,,,,,,ocular hypertension,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001231,"[""trigeminal ganglion""]",,"A ganglion on the sensory root of the fifth cranial nerve, situated in a cleft within the dura mater (trigeminal cave) on the anterior surface of the petrous portion of the temporal bone, and giving off the ophthalmic and maxillary and part of the mandibular nerve; it contains the cells of origin of most of the sensory fibers of the trigeminal nerve.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000106,,,,,,,,"A ganglion on the sensory root of the fifth cranial nerve, situated in a cleft within the dura mater (trigeminal cave) on the anterior surface of the petrous portion of the temporal bone, and giving off the ophthalmic and maxillary and part of the mandibular nerve; it contains the cells of origin of most of the sensory fibers of the trigeminal nerve.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001231,,,,,,,BrendaTissueOBO,Gasser's ganglion|ganglion of trigeminal nerve|gasserian ganglion|semilunar ganglion|ganglion trigeminale,BTO:0001231,,,,,,,,,,,,,,,,,,,trigeminal ganglion,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117486,"[""Peroxisome proliferator-activated receptor delta""]",,"A peroxisome proliferator-activated receptor delta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q03181] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117462,,,,,,,,"A peroxisome proliferator-activated receptor delta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q03181] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117486,,,,https://pharos.nih.gov/idg/targets/Q03181,,,,,,,,,,,,,PPARD,PPARB,,Q03181,,,,,,,,Peroxisome proliferator-activated receptor delta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100481,"[""Striated muscle preferentially expressed protein kinase""]",,"A striated muscle preferentially expressed protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15772] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300168,,,,,,,,"A striated muscle preferentially expressed protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15772] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100481,,,,https://pharos.nih.gov/idg/targets/Q15772,,,,,,,,,,,,,SPEG,APEG1|KIAA1297,,Q15772,,,,,,,,Striated muscle preferentially expressed protein kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100308,"[""Trimeric intracellular cation channel type B""]",,"A trimeric intracellular cation channel type B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NVV0] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300371,,,,,,,,"A trimeric intracellular cation channel type B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NVV0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100308,,,,https://pharos.nih.gov/idg/targets/Q9NVV0,,,,,,,,,,,,,TMEM38B,C9orf87,,Q9NVV0,,,,,,,,Trimeric intracellular cation channel type B,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000188,"[""HUNK kinase domain""]",,Hormonally up-regulated Neu-associated kinase; HUNK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Hormonally up-regulated Neu-associated kinase; HUNK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000188,,,,,,,,,,,,,,,,,,,200191,,,,,,,,,HUNK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117472,"[""Estrogen receptors""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00102000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117472,,,,,,,,,,,,,,,,,,,,,,,,,,,,Estrogen receptors,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12930,"[""dilated cardiomyopathy""]",,An intrinsic cardiomyopathy that is characterized by an an enlarged heart and damage to the myocardium causing the heart to pump blood inefficiently.,false,,,http://purl.obolibrary.org/obo/DOID_0060036,,,,,,,,An intrinsic cardiomyopathy that is characterized by an an enlarged heart and damage to the myocardium causing the heart to pump blood inefficiently.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12930,,,,SNOMEDCT_US_2016_03_01:74368002|SNOMEDCT_US_2016_03_01:399020009|NCI:C84673|SNOMEDCT_US_2016_03_01:195021004|OMIM:PS115200|SNOMEDCT_US_2016_03_01:195018001|SNOMEDCT_US_2016_03_01:389995008|EFO:0000407|ICD10CM:I42.0|KEGG:05414|UMLS_CUI:C0007193|MESH:D002311|ORDO:217604,primary dilated cardiomyopathy,,disease_ontology,Familial dilated cardiomyopathy|Idiopathic dilation cardiomyopathy|Congestive cardiomyopathy,DOID:12930,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [LS].",,dilated cardiomyopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12932,"[""endomyocardial fibrosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_397,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12932,,,,SNOMEDCT_US_2016_03_01:266301006|UMLS_CUI:C0553980|SNOMEDCT_US_2016_03_01:111507009|SNOMEDCT_US_2016_03_01:398716006|MESH:D004719|SNOMEDCT_US_2016_03_01:30293000|SNOMEDCT_US_2016_03_01:123264005|SNOMEDCT_US_2016_03_01:155351008|ICD9CM:425.0|NCI:C34585,Becker's disease|Obscure African cardiomyopathy (disorder)|(Becker's disease) or (obscure African cardiomyopathy)|Endomyocardial sclerosis|African endomyocardial fibrosis,,disease_ontology,,DOID:12932,,,,,,,,,,,,,,,,,,,endomyocardial fibrosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004296,"[""umbilical vein endothelial cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001854,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004296,,,,,,,BrendaTissueOBO,,BTO:0004296,,,,,,,,,,,,,,,,,,,umbilical vein endothelial cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100588,"[""Olfactory receptor 4F5""]",,"An olfactory receptor 4F5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH21] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4F5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH21] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100588,,,,https://pharos.nih.gov/idg/targets/Q8NH21,,,,,,,,,,,,,OR4F5,,,Q8NH21,,,,,,,,Olfactory receptor 4F5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004101,"[""fascicle""]",,A bundle of thin leaves of pines.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A bundle of thin leaves of pines.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004101,,,,,,,BrendaTissueOBO,plant fascicle,BTO:0004101,,,,,,,,,,,,,,,,,,,fascicle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200484,"[""SRC gene""]",,"This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400132,,,,,,,,"This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200484,,,,,,,,,,,,,,,,6714,SRC,SRC1,,,,,,,,,,SRC gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200742,"[""PTGDR gene""]",,"A prostaglandin D2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13258] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A prostaglandin D2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13258] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200742,,,,,,,,,,,,,,,,5729,PTGDR,,,,,,,,,,,PTGDR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002399,"[""PNT-2 cell""]",,Human normal prostate epithelium cell line immortalized with SV40.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002398,,,,,,,,Human normal prostate epithelium cell line immortalized with SV40.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002399,,,,,,,BrendaTissueOBO,PNT2 cell,BTO:0002399,,,,,,,,,,,,,,,,,,,PNT-2 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000397,"[""THR790 in EGFR(G719S)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000397,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR790 in EGFR(G719S),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004569,"[""ovarian fluid""]",,The ovarian fluid surrounds eggs from female fish.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The ovarian fluid surrounds eggs from female fish.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004569,mgr,2010-02-17T10:23:59Z,,,,,BrendaTissueOBO,,BTO:0004569,,,,,,,,,,,,,,,,,,,ovarian fluid,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6713,"[""cerebrovascular disease""]",,An artery disease that is characterized by dysfunction of the blood vessels supplying the brain.,false,,,http://purl.obolibrary.org/obo/DOID_0050828|http://purl.obolibrary.org/obo/DOID_936,,,,,,,,An artery disease that is characterized by dysfunction of the blood vessels supplying the brain.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6713,,,DOID:8231|DOID:3455|DOID:12214,UMLS_CUI:C0007820|MESH:D002561|SNOMEDCT_US_2016_03_01:155405006|NCI:C2938|SNOMEDCT_US_2016_03_01:155388006|ICD10CM:I67.9|SNOMEDCT_US_2016_03_01:266315008|SNOMEDCT_US_2016_03_01:195208004|ICD10CM:I63.9|EFO:0000712|SNOMEDCT_US_2016_03_01:62914000|SNOMEDCT_US_2016_03_01:195595007|ICD9CM:430-438.99|OMIM:601367|MESH:D020521|SNOMEDCT_US_2016_03_01:195249004|SNOMEDCT_US_2016_03_01:270883006|SNOMEDCT_US_2016_03_01:155412002|SNOMEDCT_US_2016_03_01:266312006|SNOMEDCT_US_2016_03_01:82797006|ICD10CM:I60-I69|ICD9CM:437.9|UMLS_CUI:C0038454|NCI:C3390|SNOMEDCT_US_2016_03_01:313267000|SNOMEDCT_US_2016_03_01:230690007,cerebrovascular disorder|Cerebrovascular accident (disorder)|cerebrovascular accident|CVA (cerebral vascular accident)|stroke,,disease_ontology,,DOID:6713,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,cerebrovascular disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400397,"[""ClC-3/CLCN3 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400341,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400397,,,,,,,,,,,,,,,,,,,,,,,,,,,,ClC-3/CLCN3 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200304,"[""SCNN1B gene""]",,"Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome. [provided by RefSeq, Apr 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400478,,,,,,,,"Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome. [provided by RefSeq, Apr 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200304,,,,,,,,,,,,,,,,6338,SCNN1B,,,,,,,,,,,SCNN1B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12466,"[""secondary hyperparathyroidism""]",,,false,,,http://purl.obolibrary.org/obo/DOID_13543,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12466,,,,MESH:D006962|UMLS_CUI:C0020503|NCI:C113335|SNOMEDCT_US_2016_03_01:91478007,secondary hyperparathyroidism NOS|secondary hyperparathyroidism (disorder),,disease_ontology,,DOID:12466,,,,,,,,,,,,,,,,,,,secondary hyperparathyroidism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200551,"[""UCK1 gene""]",,"This gene encodes a uridine-cytidine kinase that catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP) but not the phosphorylation of deoxyribonucleosides or purine ribonucleosides. This enzyme can also phosphorylate uridine and cytidine analogs and uses both ATP and GTP as a phosphate donor. Alternative splicing results in multiple splice variants encoding distinct isoforms. [provided by RefSeq, May 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03491024,,,,,,,,"This gene encodes a uridine-cytidine kinase that catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP) but not the phosphorylation of deoxyribonucleosides or purine ribonucleosides. This enzyme can also phosphorylate uridine and cytidine analogs and uses both ATP and GTP as a phosphate donor. Alternative splicing results in multiple splice variants encoding distinct isoforms. [provided by RefSeq, May 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200551,,,,,,,,,,,,,,,,83549,UCK1,URK1,,,,,,,,,,UCK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300554,"[""Kv11.1/KCNH2 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300448,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300554,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv11.1/KCNH2 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000293,"[""PHE91 in CASK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000293,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE91 in CASK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000746,"[""preadipocyte cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0003452|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000746,,,,,,,BrendaTissueOBO,proadipocyte cell line,BTO:0000746,,,,,,,,,,,,,,,,,,,preadipocyte cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200674,"[""OR7A2P gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200674,,,,,,,,,,,,,,,,390894,OR7A2P,OR7A2|OR7A7,,,,,,,,,,OR7A2P gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003317,"[""INS-1E cell""]",,"Rat insulinoma cell line, derived from parental strain INS-1.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000794,,,,,,,,"Rat insulinoma cell line, derived from parental strain INS-1.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003317,,,,,,,BrendaTissueOBO,INS1E beta cell,BTO:0003317,,,,,,,,,,,,,,,,,,,INS-1E cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300364,"[""Atp-gated p2x receptor cation channel (p2x receptor) family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300364,,,,,,,,,,,,,,,,,,,,,,,,,,,,Atp-gated p2x receptor cation channel (p2x receptor) family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000118,"[""MET132 in MARK3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000118,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET132 in MARK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000052,"[""LEU138 in DRAK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000052,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU138 in DRAK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1967,"[""leiomyosarcoma""]",,"A malignant smooth muscle cancer that can arise almost anywhere in the body, but is most common in the uterus, abdomen, or pelvis.",false,,,http://purl.obolibrary.org/obo/DOID_4230,,,,,,,,"A malignant smooth muscle cancer that can arise almost anywhere in the body, but is most common in the uterus, abdomen, or pelvis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1967,,,,SNOMEDCT_US_2016_03_01:443719001|NCI:C3158|MESH:D007890|SNOMEDCT_US_2016_03_01:51549004|SNOMEDCT_US_2016_03_01:189790006|UMLS_CUI:C0023269,Leiomyosarcomas,,disease_ontology,,DOID:1967,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,leiomyosarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200134,"[""GPR115 gene""]",,"A G-protein coupled receptor 115 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,"A G-protein coupled receptor 115 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200134,,,,,,,,,,,,,,,,221393,GPR115,PGR18,,,,,,,,,,GPR115 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000141,"[""CST-17""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000141,,,,,,,,,,,,,,,,,,,,,,,,,,,,CST-17,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000175,"[""GAK kinase domain""]",,Cyclin G associated kinase; FLJ16629; FLJ40395; GAK; MGC99654,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Cyclin G associated kinase; FLJ16629; FLJ40395; GAK; MGC99654,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000175,,,,,,,,,,,,,,,,,,,200178,,,,,,,,,GAK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100315,"[""Mitogen-activated protein kinase 1""]",,"mitogen-activated protein kinase 1 (MK01)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P28482] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300292,,,,,,,,"mitogen-activated protein kinase 1 (MK01)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P28482] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100315,,,,https://pharos.nih.gov/idg/targets/P28482,,,,,,,,,,,,,MAPK1,ERK2|PRKM1|PRKM2,,P28482,,,,,,,,Mitogen-activated protein kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400119,"[""STKR family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400107,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400119,,,,,,,,,,,,,,,,,,,,,,,,,,,,STKR family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_7765,"[""Coats disease""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_7736,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:7765,,,,ICD10CM:H35.02|MESH:D058456|OMIM:300216|UMLS_CUI:C0154832|SNOMEDCT_US_2016_03_01:193359003|SNOMEDCT_US_2016_03_01:360455002|ICD10CM:H35.07|ICD9CM:362.12|SNOMEDCT_US_2016_03_01:193360008|SNOMEDCT_US_2016_03_01:25506007,Exudative retinopathy|Coats' disease|Coats' syndrome,,disease_ontology,,DOID:7765,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Coats disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12132,"[""Wegener's granulomatosis""]",,"An autoimmune disease that is located_in lung, located_in kidney, located_in skin resulting from an autoimmune attack by antineutrophil cytoplasmic antibodies against small and medium-size blood vessels.",false,,,http://purl.obolibrary.org/obo/DOID_417,,,,,,,,"An autoimmune disease that is located_in lung, located_in kidney, located_in skin resulting from an autoimmune attack by antineutrophil cytoplasmic antibodies against small and medium-size blood vessels.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12132,,,,UMLS_CUI:C3495801|ICD10CM:M31.30|NCI:C3444|SNOMEDCT_US_2016_03_01:155445002|SNOMEDCT_US_2016_03_01:239934006|SNOMEDCT_US_2016_03_01:195353004|SNOMEDCT_US_2016_03_01:390001000|SNOMEDCT_US_2016_03_01:266323005|ICD9CM:446.4|ICD10CM:M31.3|OMIM:608710|MESH:D014890|SNOMEDCT_US_2016_03_01:23782005,Granulomatosis - Wegener's|Wegener granulomatosis|Necrotizing respiratory granulomatosis|Wegener's syndrome (disorder),,disease_ontology,,DOID:12132,,,,,,,,,,,,,,,,,,,Wegener's granulomatosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12139,"[""dysthymic disorder""]",,A mood disorder that involves the presence of a low mood almost daily over a span of at least two years.,false,,,http://purl.obolibrary.org/obo/DOID_3324,,,,,,,,A mood disorder that involves the presence of a low mood almost daily over a span of at least two years.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12139,,,,UMLS_CUI:C0013415|SNOMEDCT_US_2016_03_01:192384008|MESH:D019263|ICD10CM:F34.1|ICD9CM:300.4|NCI:C34562|SNOMEDCT_US_2016_03_01:78667006,dysthymia,,disease_ontology,,DOID:12139,,,,,,,,,,,,,,,,,,,dysthymic disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000138,"[""EPHA6 kinase domain""]",,EPH receptor A6; DKFZp434C1418; EPA6; EPHA6; FLJ35246; PRO57066,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,EPH receptor A6; DKFZp434C1418; EPA6; EPHA6; FLJ35246; PRO57066,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000138,,,,,,,,,,,,,,,,,,,200140,,,,,,,,,EPHA6 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002308,"[""myoepithelium""]",,A specialized type of epithelium that has contractile qualities.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000416,,,,,,,,A specialized type of epithelium that has contractile qualities.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002308,,,,,,,BrendaTissueOBO,,BTO:0002308,,,,,,,,,,,,,,,,,,,myoepithelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300203,"[""PDK1 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300203,,,,,,,,,,,,,,,,,,,,,,,,,,,,PDK1 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200530,"[""OR2J1 gene""]",,"An olfactory receptor 2J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZK6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZK6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200530,,,,,,,,,,,,,,,,442185,OR2J1,OR2J1P,,,,,,,,,,OR2J1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200275,"[""PIEZO2 gene""]",,"The protein encoded by this gene contains more than thirty transmembrane domains and likely functions as part of mechanically-activated (MA) cation channels. These channels serve to connect mechanical forces to biological signals. The encoded protein quickly adapts MA currents in somatosensory neurons. Defects in this gene are a cause of type 5 distal arthrogryposis. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_01400366,,,,,,,,"The protein encoded by this gene contains more than thirty transmembrane domains and likely functions as part of mechanically-activated (MA) cation channels. These channels serve to connect mechanical forces to biological signals. The encoded protein quickly adapts MA currents in somatosensory neurons. Defects in this gene are a cause of type 5 distal arthrogryposis. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200275,,,,,,,,,,,,,,,,63895,PIEZO2,C18orf30|C18orf58|FAM38B,,,,,,,,,,PIEZO2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0080110,"[""multiple pterygium syndrome""]",,"A genetic disease that is characterized by permanently bent fingers (camptodactyly), short stature, rocker-bottom or club feet, joints that are bent in a fixed position (contractures), union or webbing of the skin between the fingers (syndactyly), and/or webbing of the neck, inside bend of the elbows, back of the knees and armpits.",false,,,http://purl.obolibrary.org/obo/DOID_630,,,,,,,,"A genetic disease that is characterized by permanently bent fingers (camptodactyly), short stature, rocker-bottom or club feet, joints that are bent in a fixed position (contractures), union or webbing of the skin between the fingers (syndactyly), and/or webbing of the neck, inside bend of the elbows, back of the knees and armpits.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0080110,,,,OMIM:265000|OMIM:253290|OMIM:178110|OMIM:312150,,,,,DOID:0080110,http://purl.obolibrary.org/obo/doid#DO_MGI_slim|http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,multiple pterygium syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000156,"[""MET268 in GRK7""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000156,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET268 in GRK7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117516,"[""Androgen receptor""]",,"An androgen receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10275] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117474,,,,,,,,"An androgen receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10275] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117516,,,,https://pharos.nih.gov/idg/targets/P10275,,,,,,,,,,,,,AR,NR3C4,,P10275,,,,,,,,Androgen receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100011,"[""5-hydroxytryptamine receptor 6""]",,"A 5-hydroxytryptamine receptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P50406] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302005,,,,,,,,"A 5-hydroxytryptamine receptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P50406] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100011,,,,https://pharos.nih.gov/idg/targets/P50406,,,,,,,,,,,,,HTR6,,,P50406,,,,,,,,5-hydroxytryptamine receptor 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000290,"[""MP2K5 kinase domain""]",,Dual specificity mitogen-activated protein kinase kinase 5; mitogen-activated protein kinase kinase 5; HsT17454; MAP2K5; MAPKK5; MEK5; PRKMK5,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Dual specificity mitogen-activated protein kinase kinase 5; mitogen-activated protein kinase kinase 5; HsT17454; MAP2K5; MAPKK5; MEK5; PRKMK5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000290,,,,,,,,,,,,,,,,,,,200255,,,,,,,,,MP2K5 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000268,"[""MET kinase domain""]",,Hepatocyte growth factor receptor; AUTS9; c-Met; HGFR; MET; RCCP2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Hepatocyte growth factor receptor; AUTS9; c-Met; HGFR; MET; RCCP2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000268,,,,,,,,,,,,,,,,,,,200259,,,,,,,,,MET kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200745,"[""PTGER3 gene""]",,"A prostaglandin E2 receptor EP3 subtype that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43115] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A prostaglandin E2 receptor EP3 subtype that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43115] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200745,,,,,,,,,,,,,,,,5733,PTGER3,,,,,,,,,,,PTGER3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400061,"[""Histamine receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400061,,,,,,,,,,,,,,,,,,,,,,,,,,,,Histamine receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200332,"[""MOK gene""]",,"This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400162,,,,,,,,"This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200332,,,,,,,,,,,,,,,,5891,MOK,RAGE|RAGE1,,,,,,,,,,MOK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300058,"[""Galanin like""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300058,,,,,,,,,,,,,,,,,,,,,,,,,,,,Galanin like,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000028,"[""LEU110 in BRSK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000028,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU110 in BRSK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200576,"[""OR4C16 gene""]",,"An olfactory receptor 4C16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4C16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200576,,,,,,,,,,,,,,,,219428,OR4C16,,,,,,,,,,,OR4C16 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200216,"[""GPR97 gene""]",,"A G-protein coupled receptor 97 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86Y34] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,"A G-protein coupled receptor 97 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86Y34] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200216,,,,,,,,,,,,,,,,222487,GPR97,PGR26,,,,,,,,,,GPR97 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000180,"[""MET486 in KPCE""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000180,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET486 in KPCE,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000177,"[""GRK1 kinase domain""]",,G protein-coupled receptor kinase 1; GPRK1; GRK1; RHODK; RHODK/GRK1; RHOK; RK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,G protein-coupled receptor kinase 1; GPRK1; GRK1; RHODK; RHODK/GRK1; RHOK; RK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000177,,,,,,,,,,,,,,,,,,,200180,,,,,,,,,GRK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200408,"[""OR52A1 gene""]",,"An olfactory receptor 52A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UKL2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 52A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UKL2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200408,,,,,,,,,,,,,,,,23538,OR52A1,,,,,,,,,,,OR52A1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0080033,"[""craniometaphyseal dysplasia""]",,An osteosclerosis that has_material_basis_in mutations in the ANKH gene which results_in progressive thickening located_in skull and abnormally shaped ends of long bones in the limbs.,false,,,http://purl.obolibrary.org/obo/DOID_4254,,,,,,,,An osteosclerosis that has_material_basis_in mutations in the ANKH gene which results_in progressive thickening located_in skull and abnormally shaped ends of long bones in the limbs.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0080033,,,,OMIM:218400|OMIM:218300|OMIM:122860|OMIM:614378|OMIM:123000|OMIM:614099|ORDO:1522,,,disease_ontology,,DOID:0080033,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,craniometaphyseal dysplasia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0080038,"[""pycnodysostosis""]",,"An osteochondrodysplasia that has_material_basis_in a mutation in the CTSK gene which results_in dwarfism, brittle bones, osteopetrosis, shortening of the distal phalanges.",false,,,http://purl.obolibrary.org/obo/DOID_2256,,,,,,,,"An osteochondrodysplasia that has_material_basis_in a mutation in the CTSK gene which results_in dwarfism, brittle bones, osteopetrosis, shortening of the distal phalanges.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0080038,,,,,,,disease_ontology,,DOID:0080038,,,,,,,,,,,,,,,,,,,pycnodysostosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0080031,"[""fibrous dysplasia""]",,A bone remodeling disease that results_in the destruction of normal bone and replacing it with fibrous bone tissue.,false,,,http://purl.obolibrary.org/obo/DOID_0080005,,,,,,,,A bone remodeling disease that results_in the destruction of normal bone and replacing it with fibrous bone tissue.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0080031,,,,,,,disease_ontology,,DOID:0080031,,,,,,,,,,,,,,,,,,,fibrous dysplasia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000316,"[""NEK6 kinase domain""]",,NIMA (never in mitosis gene a)-related kinase 6; NEK6; SID6-1512,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,NIMA (never in mitosis gene a)-related kinase 6; NEK6; SID6-1512,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000316,,,,,,,,,,,,,,,,,,,200292,,,,,,,,,NEK6 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000086,"[""CDKL5 kinase domain""]",,Cyclin-dependent kinase-like 5; CDKL5; ISSX; STK9,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Cyclin-dependent kinase-like 5; CDKL5; ISSX; STK9,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000086,,,,,,,,,,,,,,,,,,,200086,,,,,,,,,CDKL5 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80259,"[""Neuropeptide B-23""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG COMPOUND:C16035,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80259,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80259,,,,,Neuropeptide B-23,,CHEBI:80259,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000280,"[""MKNK2 kinase domain""]",,MAP kinase interacting serine/threonine kinase 2; GPRK7; MKNK2; MNK2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,MAP kinase interacting serine/threonine kinase 2; GPRK7; MKNK2; MNK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000280,,,,,,,,,,,,,,,,,,,200265,,,,,,,,,MKNK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100616,"[""Phosphoglycerate kinase 2""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100616,,,,,,,,,,,,,,,,,PGK2,,,P07205,,,,,,,,Phosphoglycerate kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200487,"[""OR1F1 gene""]",,"An olfactory receptor 1F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43749] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43749] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200487,,,,,,,,,,,,,,,,4992,OR1F1,OLFMF|OR1F10|OR1F4|OR1F5|OR1F6|OR1F7|OR1F8|OR1F9,,,,,,,,,,OR1F1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200431,"[""PLK2 gene""]",,"The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400211,,,,,,,,"The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200431,,,,,,,,,,,,,,,,10769,PLK2,SNK,,,,,,,,,,PLK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400211,"[""PLK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400211,,,,,,,,,,,,,,,,,,,,,,,,,,,,PLK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001218,"[""scapula""]",,"Either of a pair of large triangular bones lying one in each dorsal lateral scapula: part of the thorax, being the principal bone of the corresponding half of the shoulder girdle, and articulating with the corresponding clavicle or coracoid.",false,,,http://purl.obolibrary.org/obo/UBERON_0001474|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000140,,,,,,,,"Either of a pair of large triangular bones lying one in each dorsal lateral scapula: part of the thorax, being the principal bone of the corresponding half of the shoulder girdle, and articulating with the corresponding clavicle or coracoid.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001218,,,,,,,BrendaTissueOBO,scapula bone|shoulder blade,BTO:0001218,,,,,,,,,,,,,,,,,,,scapula,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100126,"[""Putative gonadotropin-releasing hormone ii receptor""]",,"A gonadotropin-releasing hormone II receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P88] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300050,,,,,,,,"A gonadotropin-releasing hormone II receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P88] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100126,,,,https://pharos.nih.gov/idg/targets/Q96P88,,,,,,,,,,,,,GNRHR2,,,Q96P88,,,,,,,,Putative gonadotropin-releasing hormone ii receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100114,"[""Gamma-aminobutyric acid receptor subunit beta-2""]",,"A gamma-aminobutyric acid receptor subunit beta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47870] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300513,,,,,,,,"A gamma-aminobutyric acid receptor subunit beta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47870] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100114,,,,https://pharos.nih.gov/idg/targets/P47870,,,,,,,,,,,,,GABRB2,,,P47870,,,,,,,,Gamma-aminobutyric acid receptor subunit beta-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200518,"[""TBK1 gene""]",,"The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400164,,,,,,,,"The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200518,,,,,,,,,,,,,,,,29110,TBK1,NAK,,,,,,,,,,TBK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200008,"[""HTR2C gene""]",,"A 5-hydroxytryptamine receptor 2C that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28335] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402002,,,,,,,,"A 5-hydroxytryptamine receptor 2C that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28335] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200008,,,,,,,,,,,,,,,,3358,HTR2C,HTR1C,,,,,,,,,,HTR2C gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2367,"[""neuroaxonal dystrophy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1443,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2367,,,,SNOMEDCT_US_2016_03_01:230365004|MESH:D019150|UMLS_CUI:C0338473,,,disease_ontology,,DOID:2367,,,,,,,,,,,,,,,,,,,neuroaxonal dystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100141,"[""Glutamate receptor ionotropic, kainate 3""]",,"A glutamate receptor ionotropic, kainate 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13003] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300418,,,,,,,,"A glutamate receptor ionotropic, kainate 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13003] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100141,,,,https://pharos.nih.gov/idg/targets/Q13003,,,,,,,,,,,,,GRIK3,GLUR7,,Q13003,,,,,,,,"Glutamate receptor ionotropic, kainate 3",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001181,"[""rhizome""]",,"A somewhat elongate usually horizontal subterranean plant stem that is often thickened by deposits of reserve food material, produces shoots above and roots below, and is distinguished from a true root in possessing buds, nodes, and usually scalelike leaves.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A somewhat elongate usually horizontal subterranean plant stem that is often thickened by deposits of reserve food material, produces shoots above and roots below, and is distinguished from a true root in possessing buds, nodes, and usually scalelike leaves.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001181,,,,,,,BrendaTissueOBO,,BTO:0001181,,,,,,,,,,,,,,,,,,,rhizome,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050660,"[""Beare-Stevenson cutis gyrata syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050660,,,,OMIM:123790,,,disease_ontology,,DOID:0050660,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Beare-Stevenson cutis gyrata syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050661,"[""vitelliform macular dystrophy""]",,"A macular degeneration that it is characterized by the disruption of cells in a small area near the center of the retina, the macula and may cause progressive vision loss.",false,,,http://purl.obolibrary.org/obo/DOID_4448,,,,,,,,"A macular degeneration that it is characterized by the disruption of cells in a small area near the center of the retina, the macula and may cause progressive vision loss.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050661,,,,OMIM:608161|OMIM:153840|ICD10CM:H35.5|ORDO:1243|OMIM:616151|ORDO:99000|OMIM:153700|OMIM:616152,Best macular dystrophy|juvenile-onset vitelliform macular dystrophy|Best disease,,disease_ontology,,DOID:0050661,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,vitelliform macular dystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050667,"[""alcohol-related neurodevelopmental disorder""]",,A fetal alcohol spectrum disorder that results in central nervous system dysfunction and behavioral and/or cognitive deficits due to prenatal alcohol exposure.,false,,,http://purl.obolibrary.org/obo/DOID_0050696,,,,,,,,A fetal alcohol spectrum disorder that results in central nervous system dysfunction and behavioral and/or cognitive deficits due to prenatal alcohol exposure.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050667,,,,,static encephalopathy|ARND,,disease_ontology,,DOID:0050667,,,,,,,,,,,,,,,,,,,alcohol-related neurodevelopmental disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050665,"[""fetal alcohol syndrome""]",,"A fetal alcohol spectrum disorder that results in severe mental and physical defects which can develop in a child when the mother drinks alcohol during pregnancy. The presenting features include craniofacial dysmorphology (microcephaly, smooth philtrum, thin upper lip, small eye openings), pre- and postnatal growth deficiency, and central nervous system dysfunction.",false,,,http://purl.obolibrary.org/obo/DOID_0050696,,,,,,,,"A fetal alcohol spectrum disorder that results in severe mental and physical defects which can develop in a child when the mother drinks alcohol during pregnancy. The presenting features include craniofacial dysmorphology (microcephaly, smooth philtrum, thin upper lip, small eye openings), pre- and postnatal growth deficiency, and central nervous system dysfunction.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050665,,,,,,,disease_ontology,,DOID:0050665,,,,,,,,,,,,,,,,,,,fetal alcohol syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050662,"[""bestrophinopathy""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_4448,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050662,,,,OMIM:611809,autosomal recessive bestrophinopathy,,disease_ontology,,DOID:0050662,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,bestrophinopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000981,"[""ovotestis""]",,A hermaphrodite gonad (as in some scale insects).,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000534,,,,,,,,A hermaphrodite gonad (as in some scale insects).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000981,,,,,,,BrendaTissueOBO,,BTO:0000981,,,,,,,,,,,,,,,,,,,ovotestis,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100340,"[""Protein tweety homolog 2""]",,"A protein tweety homolog 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BSA4] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300373,,,,,,,,"A protein tweety homolog 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BSA4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100340,,,,https://pharos.nih.gov/idg/targets/Q9BSA4,,,,,,,,,,,,,TTYH2,C17orf29,,Q9BSA4,,,,,,,,Protein tweety homolog 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100230,"[""Thymidine kinase 2, mitochondrial""]",,"A thymidine kinase 2, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00142] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391008,,,,,,,,"A thymidine kinase 2, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00142] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100230,,,,https://pharos.nih.gov/idg/targets/O00142,,,,,,,,,,,,,TK2,,,O00142,,,,,,,,"Thymidine kinase 2, mitochondrial",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100014,"[""Uncharacterized aarf domain-containing protein kinase 2""]",,"An uncharacterized aarF domain-containing protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z695] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300248,,,,,,,,"An uncharacterized aarF domain-containing protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z695] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100014,,,,https://pharos.nih.gov/idg/targets/Q7Z695,,,,,,,,,,,,,ADCK2,AARF,,Q7Z695,,,,,,,,Uncharacterized aarf domain-containing protein kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100167,"[""Probable G-protein coupled receptor 179""]",,"A G-protein coupled receptor 179 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6PRD1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300004,,,,,,,,"A G-protein coupled receptor 179 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6PRD1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100167,,,,https://pharos.nih.gov/idg/targets/Q6PRD1,,,,,,,,,,,,,GPR179,GPR158L|GPR158L1,,Q6PRD1,,,,,,,,Probable G-protein coupled receptor 179,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100390,"[""Olfactory receptor 51B6""]",,"An olfactory receptor 51B6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H340] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 51B6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H340] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100390,,,,https://pharos.nih.gov/idg/targets/Q9H340,,,,,,,,,,,,,OR51B6,,,Q9H340,,,,,,,,Olfactory receptor 51B6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200128,"[""GLRA3 gene""]",,"This gene encodes a member of the ligand-gated ion channel protein family. The encoded protein is a member of the glycine receptor subfamily. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_01400527,,,,,,,,"This gene encodes a member of the ligand-gated ion channel protein family. The encoded protein is a member of the glycine receptor subfamily. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200128,,,,,,,,,,,,,,,,8001,GLRA3,,,,,,,,,,,GLRA3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5052,"[""melioidosis""]",,"A primary bacterial infectious disease that results_in infection, has_material_basis_in Burkholderia pseudomallei, which is transmitted_by contact with the contaminated water or soil. The infection has_symptom fever, has_symptom respiratory distress, has_symptom chest pain, and has_symptom stomach pain.",false,,,http://purl.obolibrary.org/obo/DOID_0050338,,,,,,,,"A primary bacterial infectious disease that results_in infection, has_material_basis_in Burkholderia pseudomallei, which is transmitted_by contact with the contaminated water or soil. The infection has_symptom fever, has_symptom respiratory distress, has_symptom chest pain, and has_symptom stomach pain.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5052,,,DOID:0050062|DOID:0050064,SNOMEDCT_US_2016_03_01:428111003|ICD9CM:025|MESH:D008554|UMLS_CUI:C0025229|ICD10CM:A24.9|SNOMEDCT_US_2016_03_01:187306003|SNOMEDCT_US_2016_03_01:34458001,Pseudoglanders|acute and fulminating melioidosis|Whitmore's disease|subacute and chronic melioidosis|Nightcliff gardener's disease,,disease_ontology,,DOID:5052,http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease|http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,melioidosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117468,"[""Retinoid x receptors""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00102000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117468,,,,,,,,,,,,,,,,,,,,,,,,,,,,Retinoid x receptors,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000061,"[""Prokineticin-1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000061,,,,,,,,,,,,,,,,,,,,,,,,,,,,Prokineticin-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004032,"[""dopaminergic neuron""]",,"A dopaminergic neuron is a neuron that releases dopamine from its synapses. Dopaminergic neurons are present chiefly in the ventral tegmental area (VTA) of the midbrain, substantia nigra pars compacta, and arcuate nucleus of the hypothalamus. They are believed to be the primary neuron used in the reward system of the ventral tegmental area and the substantia nigra pars compacta.",false,,,http://purl.obolibrary.org/obo/BTO_0000938|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A dopaminergic neuron is a neuron that releases dopamine from its synapses. Dopaminergic neurons are present chiefly in the ventral tegmental area (VTA) of the midbrain, substantia nigra pars compacta, and arcuate nucleus of the hypothalamus. They are believed to be the primary neuron used in the reward system of the ventral tegmental area and the substantia nigra pars compacta.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004032,,,,,,,BrendaTissueOBO,,BTO:0004032,,,,,,,,,,,,,,,,,,,dopaminergic neuron,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200680,"[""OR7D2 gene""]",,"An olfactory receptor 7D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RA2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 7D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RA2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200680,,,,,,,,,,,,,,,,162998,OR7D2,,,,,,,,,,,OR7D2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003542,"[""LAN-1 cell""]",,"The LAN-1 clone, a cell line derived from a human neuroblastoma, possesses muscarinic receptors.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000932,,,,,,,,"The LAN-1 clone, a cell line derived from a human neuroblastoma, possesses muscarinic receptors.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003542,,,,,,,BrendaTissueOBO,LAN1 cell,BTO:0003542,,,,,,,,,,,,,,,,,,,LAN-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_896,"[""metal metabolism disorder""]",,An inherited metabolic disorder that involves metabolic disturbances in the processing or distribution of dietary minerals.,false,,,http://purl.obolibrary.org/obo/DOID_655,,,,,,,,An inherited metabolic disorder that involves metabolic disturbances in the processing or distribution of dietary minerals.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:896,,,,MESH:D008664|UMLS_CUI:C0025534,inborn metal metabolism disorder,,disease_ontology,,DOID:896,,,,,,,,,,,,,,,,,,,metal metabolism disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_898,"[""autosomal dominant polycystic kidney disease""]",,An autosomal dominant disease characterized by the presence of multiple cysts located_in the kidney resulting from ciliopathy that disrupts the function of primary cilium.,false,,,http://purl.obolibrary.org/obo/DOID_557|http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,An autosomal dominant disease characterized by the presence of multiple cysts located_in the kidney resulting from ciliopathy that disrupts the function of primary cilium.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:898,,,,SNOMEDCT_US_2016_03_01:204954005|SNOMEDCT_US_2016_03_01:204956007|SNOMEDCT_US_2016_03_01:268233005|MESH:D007690|SNOMEDCT_US_2016_03_01:204955006|ICD10CM:Q61.3|SNOMEDCT_US_2016_03_01:156973002|ORDO:730|OMIM:PS173900|UMLS_CUI:C0022680|SNOMEDCT_US_2016_03_01:82525005|NCI:C75464|SNOMEDCT_US_2016_03_01:268332003|ICD9CM:753.12,POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1|Congenital biliary ectasias,,disease_ontology,,DOID:898,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].
Updating outdated UMLS CUI. 
Removing Caroli disease as a synonym as this is a distinct disease.",,autosomal dominant polycystic kidney disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004605,"[""U-118MG cell""]",,Human neuronal glioblastoma (grade III) cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001530,,,,,,,,Human neuronal glioblastoma (grade III) cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004605,XPMUser,2011-02-25T08:22:30Z,,,,,BrendaTissueOBO,U-118 MG cell|U-118 cell,BTO:0004605,,,,,,,,,,,,,,,,,,,U-118MG cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100656,"[""Olfactory receptor 6c3""]",,"An olfactory receptor 6C3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZP0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6C3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZP0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100656,,,,https://pharos.nih.gov/idg/targets/Q9NZP0,,,,,,,,,,,,,OR6C3,,,Q9NZP0,,,,,,,,Olfactory receptor 6c3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200088,"[""CLK3 gene""]",,"This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400140,,,,,,,,"This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200088,,,,,,,,,,,,,,,,1198,CLK3,,,,,,,,,,,CLK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004628,"[""aortic valve""]",,"One of the four valves in the heart, this valve is situated at exit of the left ventricle of the heart where the aorta begins. The aortic valve lets blood from the left ventricle be pumped up into the aorta but prevents blood once it is in the aorta from returning to the heart.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"One of the four valves in the heart, this valve is situated at exit of the left ventricle of the heart where the aorta begins. The aortic valve lets blood from the left ventricle be pumped up into the aorta but prevents blood once it is in the aorta from returning to the heart.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004628,mgr,2010-04-14T09:22:13Z,,,,,BrendaTissueOBO,,BTO:0004628,,,,,,,,,,,,,,,,,,,aortic valve,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000343,"[""THR316 in LCK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000343,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR316 in LCK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000038,"[""ALK kinase domain""]",,Anaplastic lymphoma receptor tyrosine kinase; ALK; CD246; NBLST3; TFG/ALK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Anaplastic lymphoma receptor tyrosine kinase; ALK; CD246; NBLST3; TFG/ALK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000038,,,,,,,,,,,,,,,,,,,200037,,,,,,,,,ALK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100437,"[""Olfactory receptor 52z1""]",,"An olfactory receptor 52Z1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C646] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 52Z1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C646] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100437,,,,https://pharos.nih.gov/idg/targets/P0C646,,,,,,,,,,,,,OR52Z1,OR52Z1P,,P0C646,,,,,,,,Olfactory receptor 52z1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200091,"[""CSNK2A1 gene""]",,"Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq, Jul 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400142,,,,,,,,"Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq, Jul 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200091,,,,,,,,,,,,,,,,1457,CSNK2A1,CK2A1,,,,,,,,,,CSNK2A1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001393,"[""mesenchyme""]",,"The part of the embryonic mesoderm, consisting of loosely packed, unspecialized cells set in a gelatinous ground substance, from which connective tissue, bone, cartilage, and the circulatory and lymphatic systems develop.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The part of the embryonic mesoderm, consisting of loosely packed, unspecialized cells set in a gelatinous ground substance, from which connective tissue, bone, cartilage, and the circulatory and lymphatic systems develop.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001393,,,,,,,BrendaTissueOBO,,BTO:0001393,,,,,,,,,,,,,,,,,,,mesenchyme,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100341,"[""Protein tweety homolog 3""]",,"A protein tweety homolog 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9C0H2] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300373,,,,,,,,"A protein tweety homolog 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9C0H2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100341,,,,https://pharos.nih.gov/idg/targets/Q9C0H2,,,,,,,,,,,,,TTYH3,KIAA1691,,Q9C0H2,,,,,,,,Protein tweety homolog 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001646,"[""ureteric bud""]",,An outgrowth of the mesonephric duct that gives rise to all but the nephrons of the permanent kidney.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001639,,,,,,,,An outgrowth of the mesonephric duct that gives rise to all but the nephrons of the permanent kidney.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001646,,,,,,,BrendaTissueOBO,diverticulum|metanephric bud,BTO:0001646,,,,,,,,,,,,,,,,,,,ureteric bud,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200179,"[""KCNMB4 gene""]",,"MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400441,,,,,,,,"MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200179,,,,,,,,,,,,,,,,27345,KCNMB4,,,,,,,,,,,KCNMB4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100711,"[""Putative olfactory receptor 9A1""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100711,,,,https://pharos.nih.gov/idg/targets/Q8NGU1,,,,,,,,,,,,,OR9A1P,OR9A1,,Q8NGU1,,,,,,,,Putative olfactory receptor 9A1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000162,"[""Glucagon-like peptide 1-(7-37)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000162,,,,,,,,,,,,,,,,,,,,,,,,,,,,Glucagon-like peptide 1-(7-37),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200018,"[""CHRNB1 gene""]",,"The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one beta, one gamma, and one delta subunit. This gene encodes the beta subunit of the acetylcholine receptor. The acetylcholine receptor changes conformation upon acetylcholine binding leading to the opening of an ion-conducting channel across the plasma membrane. Mutations in this gene are associated with slow-channel congenital myasthenic syndrome. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400502,,,,,,,,"The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one beta, one gamma, and one delta subunit. This gene encodes the beta subunit of the acetylcholine receptor. The acetylcholine receptor changes conformation upon acetylcholine binding leading to the opening of an ion-conducting channel across the plasma membrane. Mutations in this gene are associated with slow-channel congenital myasthenic syndrome. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200018,,,,,,,,,,,,,,,,1140,CHRNB1,ACHRB|CHRNB,,,,,,,,,,CHRNB1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100103,"[""FXYD domain-containing ion transport regulator 5""]",,"An FXYD domain-containing ion transport regulator 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96DB9] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300349,,,,,,,,"An FXYD domain-containing ion transport regulator 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96DB9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100103,,,,https://pharos.nih.gov/idg/targets/Q96DB9,,,,,,,,,,,,,FXYD5,DYSAD|IWU1,,Q96DB9,,,,,,,,FXYD domain-containing ion transport regulator 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100142,"[""Glutamate receptor ionotropic, kainate 4""]",,"A glutamate receptor ionotropic, kainate 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16099] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300419,,,,,,,,"A glutamate receptor ionotropic, kainate 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16099] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100142,,,,https://pharos.nih.gov/idg/targets/Q16099,,,,,,,,,,,,,GRIK4,GRIK,,Q16099,,,,,,,,"Glutamate receptor ionotropic, kainate 4",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000018,"[""ABL1(Q252H)-nonphosphorylated kinase domain""]",,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",false,,,http://www.drugtargetontology.org/dto/DTO_61000017,,,,,,,,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000018,,,,,,,,,,,,,,,,,,,"200016, 200017",,,,,,,,,ABL1(Q252H)-nonphosphorylated kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300449,"[""KQT subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300449,,,,,,,,,,,,,,,,,,,,,,,,,,,,KQT subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002191,"[""fibre tract""]",,"A bundle of nerve fibers (axons) having a common origin, termination, and function.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A bundle of nerve fibers (axons) having a common origin, termination, and function.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002191,,,,,,,BrendaTissueOBO,nerve fiber tract|fiber tract,BTO:0002191,,,,,,,,,,,,,,,,,,,fibre tract,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003047,"[""neurilemoma cell""]",,"A tumor of a neurilemma, the most common type of neurogenic tumor, usually isolated and encapsulated. Most are benign but occasionally they become malignant.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003045,,,,,,,,"A tumor of a neurilemma, the most common type of neurogenic tumor, usually isolated and encapsulated. Most are benign but occasionally they become malignant.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003047,,,,,,,BrendaTissueOBO,Schwannoma cell,BTO:0003047,,,,,,,,,,,,,,,,,,,neurilemoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100594,"[""Nicotinamide riboside kinase 1""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100594,,,,,,,,,,,,,,,,,NMRK1,,,Q9NWW6,,,,,,,,Nicotinamide riboside kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217575,"[""NR6A1 gene""]",,"This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_00217477,,,,,,,,"This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217575,,,,,,,,,,,,,,,,2649,NR6A1,GCNF,,,,,,,,,,NR6A1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003357,"[""ARPE cell""]",,Adult retinal pigment epithelial cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0002334|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Adult retinal pigment epithelial cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003357,,,,,,,BrendaTissueOBO,Adult retinal pigment epithelium cell,BTO:0003357,,,,,,,,,,,,,,,,,,,ARPE cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5516,"[""gastric squamous cell carcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1749|http://purl.obolibrary.org/obo/DOID_5517,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5516,,,,NCI:C5475|UMLS_CUI:C1333789,squamous cell carcinoma of stomach,,disease_ontology,,DOID:5516,,,,,,,,,,,,,,,,,,,gastric squamous cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200528,"[""OR2H2 gene""]",,"An olfactory receptor 2H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95918] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95918] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200528,,,,,,,,,,,,,,,,7932,OR2H2,FAT11|OLFR2|OR2H3,,,,,,,,,,OR2H2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100095,"[""Cation channel sperm-associated protein 3""]",,"A cation channel sperm-associated protein 3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q86XQ3] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300345,,,,,,,,"A cation channel sperm-associated protein 3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q86XQ3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100095,,,,https://pharos.nih.gov/idg/targets/Q86XQ3,,,,,,,,,,,,,CATSPER3,,,Q86XQ3,,,,,,,,Cation channel sperm-associated protein 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100260,"[""Glutamate receptor ionotropic, nmda 2d""]",,"A glutamate receptor ionotropic, NMDA 2D that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15399] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300458,,,,,,,,"A glutamate receptor ionotropic, NMDA 2D that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15399] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100260,,,,https://pharos.nih.gov/idg/targets/O15399,,,,,,,,,,,,,GRIN2D,GluN2D|NMDAR2D,,O15399,,,,,,,,"Glutamate receptor ionotropic, nmda 2d",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100772,"[""Somatostatin receptor type 3""]",,"A somatostatin receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32745] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A somatostatin receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32745] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100772,,,,https://pharos.nih.gov/idg/targets/P32745,,,,,,,,,,,,,SSTR3,,,P32745,,,,,,,,Somatostatin receptor type 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000446,"[""TSSK1 kinase domain""]",,Testis-specific serine kinase 1B; FKSG81; SPOGA4; STK22D; TSSK1; TSSK1B,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Testis-specific serine kinase 1B; FKSG81; SPOGA4; STK22D; TSSK1; TSSK1B,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000446,,,,,,,,,,,,,,,,,,,200447,,,,,,,,,TSSK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100268,"[""P2X purinoceptor 5""]",,"A P2X purinoceptor 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q93086] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300364,,,,,,,,"A P2X purinoceptor 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q93086] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100268,,,,https://pharos.nih.gov/idg/targets/Q93086,,,,,,,,,,,,,P2RX5,P2X5,,Q93086,,,,,,,,P2X purinoceptor 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200458,"[""OR6C68 gene""]",,"An olfactory receptor 6C68 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NDL8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6C68 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NDL8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200458,,,,,,,,,,,,,,,,403284,OR6C68,,,,,,,,,,,OR6C68 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000085,"[""LEU93 in DAPK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000085,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU93 in DAPK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400382,"[""CACNA1B subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400333,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400382,,,,,,,,,,,,,,,,,,,,,,,,,,,,CACNA1B subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2702,"[""pigmented villonodular synovitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2703,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2702,,,,MESH:D013586|SNOMEDCT_US_2016_03_01:71508003|SNOMEDCT_US_2016_03_01:202903009|SNOMEDCT_US_2016_03_01:703703002|ICD10CM:M12.2|NCI:C3401|UMLS_CUI:C0039106|SNOMEDCT_US_2016_03_01:95412009,villous tenosynovitis|Diffuse Giant cell tumor of Tenosynovium,,disease_ontology,,DOID:2702,,,,,,,,,,,,,,,,,,,pigmented villonodular synovitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002485,"[""atrial appendage""]",,The ear-shaped appendage of either atrium of the heart.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The ear-shaped appendage of either atrium of the heart.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002485,,,,,,,BrendaTissueOBO,atrial auricula|auricula atrialis,BTO:0002485,,,,,,,,,,,,,,,,,,,atrial appendage,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100043,"[""P829 in KIT(A829P)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100043,,,,,,,,,,,,,,,,,,,,,,,,,,,,P829 in KIT(A829P),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100704,"[""Olfactory receptor 8K1""]",,"An olfactory receptor 8K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 8K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100704,,,,https://pharos.nih.gov/idg/targets/Q8NGG5,,,,,,,,,,,,,OR8K1,,,Q8NGG5,,,,,,,,Olfactory receptor 8K1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300369,"[""Sodium channel family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300369,,,,,,,,,,,,,,,,,,,,,,,,,,,,Sodium channel family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200185,"[""GPR22 gene""]",,"A G-protein coupled receptor 22 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99680] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400053,,,,,,,,"A G-protein coupled receptor 22 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99680] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200185,,,,,,,,,,,,,,,,2845,GPR22,,,,,,,,,,,GPR22 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000443,"[""adipocyte""]",,One of the fat-laden cells making up adipose tissue.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,One of the fat-laden cells making up adipose tissue.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000443,,,,,,,BrendaTissueOBO,fat cell|lipocyte,BTO:0000443,,,,,,,,,,,,,,,,,,,adipocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200147,"[""GPR142 gene""]",,"A G-protein coupled receptor 142 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q7Z601] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 142 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q7Z601] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200147,,,,,,,,,,,,,,,,350383,GPR142,PGR2,,,,,,,,,,GPR142 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_699,"[""mitochondrial myopathy""]",,A myopathy that is characterized by mitochondrial dysfunction.,false,,,http://purl.obolibrary.org/obo/DOID_423,,,,,,,,A myopathy that is characterized by mitochondrial dysfunction.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:699,,,,OMIM:251900|MESH:D017240|UMLS_CUI:C0162670|SNOMEDCT_US_2016_03_01:240096000|NCI:C101328|SNOMEDCT_US_2016_03_01:16851005,mitochondrial cytopathy (disorder),,disease_ontology,,DOID:699,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,mitochondrial myopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_693,"[""dental enamel hypoplasia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_214,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:693,,,,SNOMEDCT_US_2016_03_01:699421005|NCI:C34529|UMLS_CUI:C0011351|SNOMEDCT_US_2016_03_01:26597004|SNOMEDCT_US_2016_03_01:699382004|MESH:D003744|SNOMEDCT_US_2016_03_01:196277000,Enamel Hypoplasia|Enamel hypoplasia (disorder)|Enamel hypoplasia,,disease_ontology,,DOID:693,,,,,,,,,,,,,,,,,,,dental enamel hypoplasia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_698,"[""dentin sensitivity""]",,,false,,,http://purl.obolibrary.org/obo/DOID_214,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:698,,,,UMLS_CUI:C0011432|MESH:D003807|NCI:C50778|SNOMEDCT_US_2016_03_01:13468005,Sensitive dentin,,disease_ontology,,DOID:698,,,,,,,,,,,,,,,,,,,dentin sensitivity,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200296,"[""MAP4K4 gene""]",,"The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400288,,,,,,,,"The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200296,,,,,,,,,,,,,,,,9448,MAP4K4,HGK|KIAA0687|NIK,,,,,,,,,,MAP4K4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100518,"[""Serine/threonine-protein kinase tbk1""]",,"A serine/threonine-protein kinase TBK1 that is encoded in the genome of human. [PMID:17327220, PRO:CNA, Reactome:REACT_21591] |serine/threonine-protein kinase tbk1 (TBK1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300164,,,,,,,,"A serine/threonine-protein kinase TBK1 that is encoded in the genome of human. [PMID:17327220, PRO:CNA, Reactome:REACT_21591] |serine/threonine-protein kinase tbk1 (TBK1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100518,,,,https://pharos.nih.gov/idg/targets/Q9UHD2,,,,,,,,,,,,,TBK1,NAK,,Q9UHD2,,,,,,,,Serine/threonine-protein kinase tbk1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_7475,"[""diverticulitis""]",,An intestinal disease characterized by the formation and inflammation of diverticula within the bowel wall.,false,,,http://purl.obolibrary.org/obo/DOID_5295,,,,,,,,An intestinal disease characterized by the formation and inflammation of diverticula within the bowel wall.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:7475,,,,SNOMEDCT_US_2016_03_01:18126004|SNOMEDCT_US_2016_03_01:197102009|UMLS_CUI:C0012813|NCI:C26752|SNOMEDCT_US_2016_03_01:197095003|SNOMEDCT_US_2016_03_01:197103004|SNOMEDCT_US_2016_03_01:155779000|MESH:D004238|SNOMEDCT_US_2016_03_01:307496006,,,disease_ontology,,DOID:7475,,,,,,,,,,,,,,,,,,,diverticulitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300189,"[""AXL family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300189,,,,,,,,,,,,,,,,,,,,,,,,,,,,AXL family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200826,"[""XCR1 gene""]",,"A chemokine XC receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46094] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A chemokine XC receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46094] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200826,,,,,,,,,,,,,,,,2829,XCR1,CCXCR1|GPR5,,,,,,,,,,XCR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200098,"[""FAM26D gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400335,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200098,,,,,,,,,,,,,,,,221301,FAM26D,C6orf78,,,,,,,,,,FAM26D gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300177,"[""PSK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300177,,,,,,,,,,,,,,,,,,,,,,,,,,,,PSK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050765,"[""neuroacanthocytosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1289,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050765,lschriml,2013-01-17T12:54:19Z,,,,,disease_ontology,,DOID:0050765,,,,,,,,,,,,,,,,,,,neuroacanthocytosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050766,"[""chorea-acanthocytosis""]",,"A neuroacanthocytosis that has_material_basis_in homozygous or compound heterozygous mutation in the VPS13A gene, which encodes chorein, on chromosome 9q21; it is characterized by progressive neurodegeneration and red cell acanthocytosis, with onset in the third to fifth decade of life.",false,,,http://purl.obolibrary.org/obo/DOID_0050765,,,,,,,,"A neuroacanthocytosis that has_material_basis_in homozygous or compound heterozygous mutation in the VPS13A gene, which encodes chorein, on chromosome 9q21; it is characterized by progressive neurodegeneration and red cell acanthocytosis, with onset in the third to fifth decade of life.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050766,lschriml,2013-01-17T12:54:19Z,,OMIM:200150|ICD10CM:E78.6|UMLS_CUI:C0393576|ORDO:2388,Levine-Critchley syndrome|choreoacanthocytosis,,disease_ontology,,DOID:0050766,,,,,,,,,,,,,,,,,,,chorea-acanthocytosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100315,"[""Transmembrane channel-like protein 7""]",,"A transmembrane channel-like protein 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z402] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300372,,,,,,,,"A transmembrane channel-like protein 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z402] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100315,,,,https://pharos.nih.gov/idg/targets/Q7Z402,,,,,,,,,,,,,TMC7,,,Q7Z402,,,,,,,,Transmembrane channel-like protein 7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300494,"[""Alpha-5/CHRNA5 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300494,,,,,,,,,,,,,,,,,,,,,,,,,,,,Alpha-5/CHRNA5 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100030,"[""L1047 in PIK3CA(H1047L)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100030,,,,,,,,,,,,,,,,,,,,,,,,,,,,L1047 in PIK3CA(H1047L),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300191,"[""MAPK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300111,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300191,,,,,,,,,,,,,,,,,,,,,,,,,,,,MAPK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200279,"[""MAP3K13 gene""]",,"The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400285,,,,,,,,"The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200279,,,,,,,,,,,,,,,,9175,MAP3K13,LZK,,,,,,,,,,MAP3K13 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491006,"[""AK3 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491014,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491006,,,,,,,,,,,,,,,,,,,,,,,,,,,,AK3 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200394,"[""OR51F1 gene""]",,"An olfactory receptor 51F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NGY5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 51F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NGY5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200394,,,,,,,,,,,,,,,,256892,OR51F1,OR51F1P,,,,,,,,,,OR51F1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4481,"[""allergic rhinitis""]",,"A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.",false,,,http://purl.obolibrary.org/obo/DOID_4483,,,,,,,,"A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4481,,,DOID:8242|DOID:14030|DOID:8241|DOID:12089,OMIM:607154|SNOMEDCT_US_2016_03_01:38103000|NCI:C34987|UMLS_CUI:C0002103|EFO:0003956,hay fever|seasonal allergic rhinitis|atopic rhinitis|Non-seasonal allergic rhinitis|Perenial allergic rhinitis|pollenosis,,disease_ontology,,DOID:4481,,,,,,,,,,,,,,,,,,,allergic rhinitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3098,"[""small cell sarcoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_201,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3098,,,,UMLS_CUI:C0206652|MESH:D018228|NCI:C3746|SNOMEDCT_US_2016_03_01:73506006,,,disease_ontology,,DOID:3098,,,,,,,,,,,,,,,,,,,small cell sarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200152,"[""KCNJ13 gene""]",,"This gene encodes a member of the inwardly rectifying potassium channel family of proteins. Members of this family form ion channel pores that allow potassium ions to pass into a cell. The encoded protein belongs to a subfamily of low signal channel conductance proteins that have a low dependence on potassium concentration. Mutations in this gene are associated with snowflake vitreoretinal degeneration. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400424,,,,,,,,"This gene encodes a member of the inwardly rectifying potassium channel family of proteins. Members of this family form ion channel pores that allow potassium ions to pass into a cell. The encoded protein belongs to a subfamily of low signal channel conductance proteins that have a low dependence on potassium concentration. Mutations in this gene are associated with snowflake vitreoretinal degeneration. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200152,,,,,,,,,,,,,,,,3769,KCNJ13,,,,,,,,,,,KCNJ13 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300455,"[""NR2A/GRIN2A subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300455,,,,,,,,,,,,,,,,,,,,,,,,,,,,NR2A/GRIN2A subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14448,"[""46 XY gonadal dysgenesis""]",,"A gonadal dysgenesis that is characterized by a normal 46,XY karyotype along with a progressive loss of germ cells on the developing gonads of an embryo.",false,,,http://purl.obolibrary.org/obo/DOID_14447,,,,,,,,"A gonadal dysgenesis that is characterized by a normal 46,XY karyotype along with a progressive loss of germ cells on the developing gonads of an embryo.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14448,,,,OMIM:607080|OMIM:612965|OMIM:613080|OMIM:614279|UMLS_CUI:C0018054|OMIM:613762|OMIM:400044|NCI:C120198|OMIM:154230|MESH:D006061|OMIM:616067|OMIM:300018|OMIM:233420,"Swyer syndrome|46,XY SEX REVERSAL|Pure gonadal dysgenesis 46,XY",,disease_ontology,,DOID:14448,,,,,,,,,,,,,,,,,"The term 46,XY DSD has replaced the following terms Male pseudohermaphrodite, Undervirilization of an XY male, Undermasculinization of an XY male, Mixed gonadal dysgenesis, Partial gonadal dysgenesis.

OMIM mapping confirmed by DO. [SN].
OMIM mapping confirmed by DO. [LS].",,46 XY gonadal dysgenesis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14447,"[""gonadal dysgenesis""]",,A hypogonadism that is characterized by a progressive loss of germ cells on the developing gonads of an embryo.,false,,,http://purl.obolibrary.org/obo/DOID_1924,,,,,,,,A hypogonadism that is characterized by a progressive loss of germ cells on the developing gonads of an embryo.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14447,,,,SNOMEDCT_US_2016_03_01:205681004|NCI:C61420|UMLS_CUI:C0018051|SNOMEDCT_US_2016_03_01:205692003|SNOMEDCT_US_2016_03_01:38804009|SNOMEDCT_US_2016_03_01:157020008|SNOMEDCT_US_2016_03_01:205695001|ICD9CM:758.6|MESH:D006059|SNOMEDCT_US_2016_03_01:268356004,Gonadal dysgenesis syndrome,,disease_ontology,,DOID:14447,,,,,,,,,,,,,,,,,,,gonadal dysgenesis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14449,"[""mixed gonadal dysgenesis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3491,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14449,,,,SNOMEDCT_US_2016_03_01:205682006|SNOMEDCT_US_2016_03_01:83579008|MESH:D006060|UMLS_CUI:C0018055,,,disease_ontology,,DOID:14449,,,,,,,,,,,,,,,,,,,mixed gonadal dysgenesis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14443,"[""cholinergic urticaria""]",,An urticaria induced by sweating.,false,,,http://purl.obolibrary.org/obo/DOID_0060220,,,,,,,,An urticaria induced by sweating.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14443,,,,UMLS_CUI:C0152230|ICD10CM:L50.5|ICD9CM:708.5|SNOMEDCT_US_2016_03_01:73098005,,,disease_ontology,,DOID:14443,,,,,,,,,,,,,,,,,,,cholinergic urticaria,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100263,"[""Nadph oxidase 5""]",,"An NADPH oxidase 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96PH1] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300346,,,,,,,,"An NADPH oxidase 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96PH1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100263,,,,https://pharos.nih.gov/idg/targets/Q96PH1,,,,,,,,,,,,,NOX5,,,Q96PH1,,,,,,,,Nadph oxidase 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100400,"[""Olfactory receptor 51I2""]",,"An olfactory receptor 51I2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H344] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 51I2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H344] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100400,,,,https://pharos.nih.gov/idg/targets/Q9H344,,,,,,,,,,,,,OR51I2,,,Q9H344,,,,,,,,Olfactory receptor 51I2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000313,"[""THR264 in PTK6""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000313,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR264 in PTK6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3310,"[""atopic dermatitis""]",,A dermatitis that is a chronically relapsing inflammatory allergic response located_in the skin that causes itching and flaking.,false,,,http://purl.obolibrary.org/obo/DOID_2723,,,,,,,,A dermatitis that is a chronically relapsing inflammatory allergic response located_in the skin that causes itching and flaking.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3310,,,,ICD10CM:L20.9|SNOMEDCT_US_2016_03_01:200772001|OMIM:PS603165|ICD10CM:L20.81|ICD10CM:L20|UMLS_CUI:C0011615|SNOMEDCT_US_2016_03_01:24079001|EFO:0000274|MESH:D003876|OMIM:603165|SNOMEDCT_US_2016_03_01:200779005|SNOMEDCT_US_2016_03_01:200775004|SNOMEDCT_US_2016_03_01:156331003,Besnier's prurigo|atopic eczema|Allergic (intrinsic) eczema (disorder)|Besnier's prurigo (disorder)|Atopic dermatitis (disorder)|Atopic dermatitis NOS (disorder)|Atopic dermatitis|allergic dermatitis|Atopic neurodermatitis (disorder),,disease_ontology,,DOID:3310,,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,atopic dermatitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1184,"[""nephrotic syndrome""]",,Xref MGI.,false,,,http://purl.obolibrary.org/obo/DOID_2527,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1184,,,,OMIM:615861|SNOMEDCT_US_2016_03_01:155851004|OMIM:615008|OMIM:600995|OMIM:256370|OMIM:615244|SNOMEDCT_US_2016_03_01:52254009|OMIM:615573|UMLS_CUI:C0027726|MESH:D009404|OMIM:614196|ICD10CM:N04|OMIM:256300|OMIM:610725|NCI:C34845|SNOMEDCT_US_2016_03_01:197611005|ICD9CM:581|OMIM:614199,finnish congenital nephrosis,,disease_ontology,,DOID:1184,,,,,,,,,,,,,,,,,Xref MGI.,,nephrotic syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11847,"[""coronary thrombosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3393,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11847,,,,UMLS_CUI:C0010072|ICD10CM:I21|SNOMEDCT_US_2016_03_01:266288001|MESH:D003328|SNOMEDCT_US_2016_03_01:398274000|SNOMEDCT_US_2016_03_01:155304006|SNOMEDCT_US_2016_03_01:194796000|ICD10CM:I22|SNOMEDCT_US_2016_03_01:66514008,Coronary artery thrombosis (disorder),,disease_ontology,,DOID:11847,,,,,,,,,,,,,,,,,,,coronary thrombosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001110,"[""prepupa""]",,1: An inactive stage just before the pupa in the development of certain insects. 2:The form of an insect in this stage.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001143,,,,,,,,1: An inactive stage just before the pupa in the development of certain insects. 2:The form of an insect in this stage.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001110,,,,,,,BrendaTissueOBO,,BTO:0001110,,,,,,,,,,,,,,,,,,,prepupa,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8622,"[""measles""]",,"A viral infectious disease that results_in infection located_in skin, has_material_basis_in Measles virus, which is transmitted_by contact with oronasal secretions, or semen of an infected person. The infection has_symptom fever, has_symptom cough, has_symptom coryza, has_symptom conjunctivitis, and has_symptom maculopapular, erythematous rash.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in infection located_in skin, has_material_basis_in Measles virus, which is transmitted_by contact with oronasal secretions, or semen of an infected person. The infection has_symptom fever, has_symptom cough, has_symptom coryza, has_symptom conjunctivitis, and has_symptom maculopapular, erythematous rash.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8622,,,DOID:8963|DOID:8621|DOID:9112,ICD9CM:055|SNOMEDCT_US_2016_03_01:154338006|NCI:C96406|SNOMEDCT_US_2016_03_01:14189004|UMLS_CUI:C0025007|MESH:D008457|ICD10CM:B05.9|ICD10CM:B05,morbilli,,disease_ontology,,DOID:8622,,,,,,,,,,,,,,,,,,,measles,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300001,"[""GPCR""]",,G-protein-coupled receptors (GPCRs) are the largest and most diverse group of membrane receptors in eukaryotes.,false,,,http://purl.obolibrary.org/obo/PR_000000001,,,,,,,,G-protein-coupled receptors (GPCRs) are the largest and most diverse group of membrane receptors in eukaryotes.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300001,,,,,,,,,,,,,,,,,,,,,,,,,,,https://www.nature.com/scitable/topicpage/gpcr-14047471,GPCR,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200405,"[""PGK1 gene""]",,"The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome. [provided by RefSeq, Jan 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03491013,,,,,,,,"The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome. [provided by RefSeq, Jan 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200405,,,,,,,,,,,,,,,,5230,PGK1,PGKA,,,,,,,,,,PGK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300247,"[""ABC1-B subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300120,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300247,,,,,,,,,,,,,,,,,,,,,,,,,,,,ABC1-B subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100346,"[""Muscle, skeletal receptor tyrosine-protein kinase""]",,"muscle, skeletal receptor tyrosine-protein kinase (MUSK)  with  no mutation  in a nonphosphorylated state|A muscle, skeletal receptor tyrosine-protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15146] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300195,,,,,,,,"muscle, skeletal receptor tyrosine-protein kinase (MUSK)  with  no mutation  in a nonphosphorylated state|A muscle, skeletal receptor tyrosine-protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15146] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100346,,,,https://pharos.nih.gov/idg/targets/O15146,,,,,,,,,,,,,MUSK,,,O15146,,,,,,,,"Muscle, skeletal receptor tyrosine-protein kinase",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9562,"[""primary ciliary dyskinesia""]",,"A ciliopathy that is characterized by impaired function of the cilia lining the respiratory tract (lower and upper, sinuses, Eustachian tube, middle ear) and fallopian tube.",false,,,http://purl.obolibrary.org/obo/DOID_0060340,,,,,,,,"A ciliopathy that is characterized by impaired function of the cilia lining the respiratory tract (lower and upper, sinuses, Eustachian tube, middle ear) and fallopian tube.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9562,,,DOID:2925,NCI:C84638|MESH:D002925|SNOMEDCT_US_2016_03_01:9057007|SNOMEDCT_US_2016_03_01:86204009|UMLS_CUI:C0008780|OMIM:PS244400,ciliary motility disorder|immotile ciliary syndrome,,disease_ontology,,DOID:9562,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,primary ciliary dyskinesia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_0900099,"[""CCK-4""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_0900099,,,,,,,,,,,,,,,,,,,,,,,,,,,,CCK-4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000188,"[""MET602 in TTK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000188,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET602 in TTK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400157,"[""FER family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400157,,,,,,,,,,,,,,,,,,,,,,,,,,,,FER family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004328,"[""DAOY cell""]",,Human medulloblastoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001359,,,,,,,,Human medulloblastoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004328,,,,,,,BrendaTissueOBO,,BTO:0004328,,,,,,,,,,,,,,,,,,,DAOY cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1373,"[""endometrial stromal nodule""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060095,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1373,,,,NCI:C4262|UMLS_CUI:C0334485|SNOMEDCT_US_2016_03_01:70971005|SNOMEDCT_US_2016_03_01:189810002,,,disease_ontology,,DOID:1373,,,,,,,,,,,,,,,,,,,endometrial stromal nodule,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002148,"[""gas bladder""]",,"A thin membranous, sometimes alveolated sac in the dorsal portion of the abdominal cavity. Contains a varying mixture of gases, not identical to the composition of air. May be one, two or three chambered. May be connected to the gut by a tube, the ductus pneumaticus (then called physostomous) or unconnected (then called physoclistous). May function as one or more of:- hydrostatic organ, sound producing organ, sound receptor, respiratory organ. Found in Actinopterygii. Often lacking in bottom fishes.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000123,,,,,,,,"A thin membranous, sometimes alveolated sac in the dorsal portion of the abdominal cavity. Contains a varying mixture of gases, not identical to the composition of air. May be one, two or three chambered. May be connected to the gut by a tube, the ductus pneumaticus (then called physostomous) or unconnected (then called physoclistous). May function as one or more of:- hydrostatic organ, sound producing organ, sound receptor, respiratory organ. Found in Actinopterygii. Often lacking in bottom fishes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002148,,,,,,,BrendaTissueOBO,,BTO:0002148,,,,,,,,,,,,,,,,,,,gas bladder,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000255,"[""MAP3K4 kinase domain""]",,Mitogen-activated protein kinase kinase kinase 4; FLJ42439; KIAA0213; MAP3K4; MAPKKK4; MEKK4; MTK1; PRO0412,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase kinase kinase 4; FLJ42439; KIAA0213; MAP3K4; MAPKKK4; MEKK4; MTK1; PRO0412,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000255,,,,,,,,,,,,,,,,,,,200239,,,,,,,,,MAP3K4 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100040,"[""Adhesion G protein-coupled receptor B2""]",,"A brain-specific angiogenesis inhibitor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60241] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,"A brain-specific angiogenesis inhibitor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60241] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100040,,,,https://pharos.nih.gov/idg/targets/O60241,,,,,,,,,,,,,BAI2,ADGRB2,,O60241,,,,,,,,Adhesion G protein-coupled receptor B2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400125,"[""RGC family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400110,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400125,,,,,,,,,,,,,,,,,,,,,,,,,,,,RGC family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200325,"[""TRPC7 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400582,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200325,,,,,,,,,,,,,,,,57113,TRPC7,TRP7,,,,,,,,,,TRPC7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000054,"[""albumen gland""]",,The posterior oviduct opens into the large white albumen gland which adds a layer of albumen to the zygote before it reaches the egg capsule gland.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000254,,,,,,,,The posterior oviduct opens into the large white albumen gland which adds a layer of albumen to the zygote before it reaches the egg capsule gland.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000054,,,,,,,BrendaTissueOBO,,BTO:0000054,,,,,,,,,,,,,,,,,,,albumen gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000306,"[""THR123 in GAK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000306,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR123 in GAK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200682,"[""OR7G1 gene""]",,"An olfactory receptor 7G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 7G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200682,,,,,,,,,,,,,,,,125962,OR7G1,OR7G1P,,,,,,,,,,OR7G1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200403,"[""OR51M1 gene""]",,"An olfactory receptor 51M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H341] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 51M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H341] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200403,,,,,,,,,,,,,,,,390059,OR51M1,,,,,,,,,,,OR51M1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100331,"[""Mitogen-activated protein kinase kinase kinase mlt""]",,A mitogen-activated protein kinase kinase kinase MLT that is encoded in the genome of human. |mitogen-activated protein kinase kinase kinase mlt (MLTK)  with  no mutation  in a nonphosphorylated state,false,,,http://www.drugtargetontology.org/dto/DTO_03300284,,,,,,,,A mitogen-activated protein kinase kinase kinase MLT that is encoded in the genome of human. |mitogen-activated protein kinase kinase kinase mlt (MLTK)  with  no mutation  in a nonphosphorylated state,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100331,,,,https://pharos.nih.gov/idg/targets/Q9NYL2,,,,,,,,,,,,,ZAK,MLTK,,Q9NYL2,,,,,,,,Mitogen-activated protein kinase kinase kinase mlt,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300294,"[""P38 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300191,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300294,,,,,,,,,,,,,,,,,,,,,,,,,,,,P38 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060479,"[""Shwachman-Diamond syndrome""]",,"A syndrome characterized by exocrine pancreatic insufficiency, bone marrow failure and skeletal abnormalities.",false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,"A syndrome characterized by exocrine pancreatic insufficiency, bone marrow failure and skeletal abnormalities.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060479,,,,ICD10CM:D61.0|MESH:C537330|OMIM:260400,pancreatic insufficiency and bone marrow dysfunction|Shwachman syndrome|Shwachman-Bodian-Diamond syndrome,,,,,,,,,,,,,,,,,,,,,,,Shwachman-Diamond syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060473,"[""Kabuki syndrome""]",,"A syndrome characterized by  multiple congenital anomalies and mental retardation. Other characteristics include a peculiar facial gestalt, short stature, skeletal and visceral abnormalities, cardiac anomalies, and immunological defects.",false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,"A syndrome characterized by  multiple congenital anomalies and mental retardation. Other characteristics include a peculiar facial gestalt, short stature, skeletal and visceral abnormalities, cardiac anomalies, and immunological defects.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060473,elvira,2015-11-18T16:21:35Z,,SNOMEDCT_US_2016_03_01:313426007|UMLS_CUI:C0796004|OMIM:147920|OMIM:300867|MESH:C537705|SNOMEDCT_US_2016_03_01:205805008|ORDO:2322,KMS|Kabuki make up syndrome|Niikawa-Kuroki syndrome,,disease_ontology,,DOID:0060473,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,Kabuki syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200318,"[""TPCN2 gene""]",,"This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.[provided by RefSeq, Dec 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400481,,,,,,,,"This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.[provided by RefSeq, Dec 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200318,,,,,,,,,,,,,,,,219931,TPCN2,TPC2,,,,,,,,,,TPCN2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003041,"[""Ishikawa cell""]",,The cell line Ishikawa was established from an endometrial adenocarcinoma from a 39-year-old Asian woman.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003040,,,,,,,,The cell line Ishikawa was established from an endometrial adenocarcinoma from a 39-year-old Asian woman.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003041,,,,,,,BrendaTissueOBO,,BTO:0003041,,,,,,,,,,,,,,,,,,,Ishikawa cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200148,"[""GPR143 gene""]",,"A G-protein coupled receptor 143 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51810] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400006,,,,,,,,"A G-protein coupled receptor 143 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51810] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200148,,,,,,,,,,,,,,,,4935,GPR143,OA1,,,,,,,,,,GPR143 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200436,"[""PRKDC gene""]",,"This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400309,,,,,,,,"This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200436,,,,,,,,,,,,,,,,5591,PRKDC,HYRC|HYRC1,,,,,,,,,,PRKDC gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000267,"[""MERTK kinase domain""]",,C-mer proto-oncogene tyrosine kinase; c-mer; MER; MERTK; MGC133349; RP38,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,C-mer proto-oncogene tyrosine kinase; c-mer; MER; MERTK; MGC133349; RP38,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000267,,,,,,,,,,,,,,,,,,,200258,,,,,,,,,MERTK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400574,"[""MCOLN1 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400452,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400574,,,,,,,,,,,,,,,,,,,,,,,,,,,,MCOLN1 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300462,"[""RYR3 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300354,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300462,,,,,,,,,,,,,,,,,,,,,,,,,,,,RYR3 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200067,"[""CDK20 gene""]",,"The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Dec 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400259,,,,,,,,"The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Dec 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200067,,,,,,,,,,,,,,,,23552,CDK20,CCRK|CDCH,,,,,,,,,,CDK20 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391028,"[""Type II pantothenate kinase family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300324,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391028,,,,,,,,,,,,,,,,,,,,,,,,,,,,Type II pantothenate kinase family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001711,"[""melanophore""]",,"A pigment cell that contains melanin, especially as found in the skin of amphibians and reptiles.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001470,,,,,,,,"A pigment cell that contains melanin, especially as found in the skin of amphibians and reptiles.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001711,,,,,,,BrendaTissueOBO,,BTO:0001711,,,,,,,,,,,,,,,,,,,melanophore,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400529,"[""GLRB sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400409,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400529,,,,,,,,,,,,,,,,,,,,,,,,,,,,GLRB sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300592,"[""TRPV3 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300484,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300592,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPV3 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100568,"[""Serine/threonine-protein kinase wnk2""]",,"A serine/threonine-protein kinase WNK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y3S1] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300244,,,,,,,,"A serine/threonine-protein kinase WNK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y3S1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100568,,,,https://pharos.nih.gov/idg/targets/Q9Y3S1,,,,,,,,,,,,,WNK2,KIAA1760|PRKWNK2|SDCCAG43,,Q9Y3S1,,,,,,,,Serine/threonine-protein kinase wnk2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100549,"[""Olfactory receptor 2t5""]",,"An olfactory receptor 2T5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IEZ7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2T5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IEZ7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100549,,,,https://pharos.nih.gov/idg/targets/Q6IEZ7,,,,,,,,,,,,,OR2T5,,,Q6IEZ7,,,,,,,,Olfactory receptor 2t5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200500,"[""OR1L8 gene""]",,"An olfactory receptor 1L8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1L8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200500,,,,,,,,,,,,,,,,138881,OR1L8,,,,,,,,,,,OR1L8 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3341,"[""osteitis fibrosa""]",,"A bone resorption disease that has_material_basis_in hyperparathyroidism which results_in hyperactivity in osteoclasts, deformity, and loss of mass located_in bone.",false,,,http://purl.obolibrary.org/obo/DOID_0080011,,,,,,,,"A bone resorption disease that has_material_basis_in hyperparathyroidism which results_in hyperactivity in osteoclasts, deformity, and loss of mass located_in bone.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3341,,,,SNOMEDCT_US_2016_03_01:190451000|NCI:C34875|SNOMEDCT_US_2016_03_01:84727000|MESH:D010002|UMLS_CUI:C0029405|SNOMEDCT_US_2016_03_01:190453002,Osteitis fibrosa cystica generalisata (disorder)|Von Recklinghausen's bone disease|hyperparathyroid bone disease,,disease_ontology,,DOID:3341,,,,,,,,,,,,,,,,,,,osteitis fibrosa,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000347,"[""reticulum""]",,The second compartment of the stomach of a ruminant in which folds of the mucous membrane form hexagonal cells.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000480,,,,,,,,The second compartment of the stomach of a ruminant in which folds of the mucous membrane form hexagonal cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000347,,,,,,,BrendaTissueOBO,,BTO:0000347,,,,,,,,,,,,,,,,,,,reticulum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200126,"[""EPHA2 gene""]",,"This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400153,,,,,,,,"This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200126,,,,,,,,,,,,,,,,1969,EPHA2,ECK,,,,,,,,,,EPHA2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100331,"[""Transient receptor potential cation channel subfamily M member 7""]",,"A transient receptor potential cation channel subfamily M member 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96QT4] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300588,,,,,,,,"A transient receptor potential cation channel subfamily M member 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96QT4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100331,,,,https://pharos.nih.gov/idg/targets/Q96QT4,,,,,,,,,,,,,TRPM7,CHAK1|LTRPC7,,Q96QT4,,,,,,,,Transient receptor potential cation channel subfamily M member 7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300170,"[""CK1 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300112,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300170,,,,,,,,,,,,,,,,,,,,,,,,,,,,CK1 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000132,"[""blood platelet""]",,"A minute, nonnucleated, disklike cytoplasmic body found in the blood plasma of mammals that is derived from a megakaryocyte and functions to promote blood clotting.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A minute, nonnucleated, disklike cytoplasmic body found in the blood plasma of mammals that is derived from a megakaryocyte and functions to promote blood clotting.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000132,,,,,,,BrendaTissueOBO,platelet|thrombocyte,BTO:0000132,,,,,,,,,,,,,,,,,,,blood platelet,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100201,"[""G-protein coupled receptor 55""]",,"A G-protein coupled receptor 55 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y2T6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 55 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y2T6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100201,,,,https://pharos.nih.gov/idg/targets/Q9Y2T6,,,,,,,,,,,,,GPR55,,,Q9Y2T6,,,,,,,,G-protein coupled receptor 55,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000348,"[""THR341 in SRC""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000348,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR341 in SRC,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2095,"[""sweat gland cancer""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4159|http://purl.obolibrary.org/obo/DOID_1383,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2095,,,,NCI:C4810|SNOMEDCT_US_2016_03_01:255095005|UMLS_CUI:C1321904|SNOMEDCT_US_2016_03_01:188083002|SNOMEDCT_US_2016_03_01:359719004|SNOMEDCT_US_2016_03_01:32272007|ICD10CM:C44,malignant neoplasm of sweat gland|malignant tumor of the Sweat gland,,disease_ontology,,DOID:2095,,,,,,,,,,,,,,,,,,,sweat gland cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003433,"[""endometrial gland""]",,The mucous secreting gland associated with the epithelium lining the uterus. These glands develop and secrete each menstrual cycle and are thought to provide initial blastocyst nutrition prior to implantation.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000254,,,,,,,,The mucous secreting gland associated with the epithelium lining the uterus. These glands develop and secrete each menstrual cycle and are thought to provide initial blastocyst nutrition prior to implantation.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003433,,,,,,,BrendaTissueOBO,,BTO:0003433,,,,,,,,,,,,,,,,,,,endometrial gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_591,"[""phobic disorder""]",,An anxiety disorder where fear and anxiety are triggered by a specific stimulus or situation.,false,,,http://purl.obolibrary.org/obo/DOID_2030,,,,,,,,An anxiety disorder where fear and anxiety are triggered by a specific stimulus or situation.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:591,,,,NCI:C35420|SNOMEDCT_US_2016_03_01:192398000|ICD10CM:F40|SNOMEDCT_US_2016_03_01:268630000|UMLS_CUI:C0349231|ICD10CM:F40.9|SNOMEDCT_US_2016_03_01:154884005|ICD9CM:300.2|SNOMEDCT_US_2016_03_01:191734001|MESH:D010698|SNOMEDCT_US_2016_03_01:192393009|SNOMEDCT_US_2016_03_01:191721002|SNOMEDCT_US_2016_03_01:65673007|SNOMEDCT_US_2016_03_01:191720001|ICD9CM:300.20|SNOMEDCT_US_2016_03_01:386808001|SNOMEDCT_US_2016_03_01:52039009|SNOMEDCT_US_2016_03_01:386810004,,,disease_ontology,,DOID:591,,,,,,,,,,,,,,,,,,,phobic disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_594,"[""panic disorder""]",,"An anxiety disorder that is characterized by unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress.",false,,,http://purl.obolibrary.org/obo/DOID_2030,,,,,,,,"An anxiety disorder that is characterized by unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:594,,,,SNOMEDCT_US_2016_03_01:268627007|SNOMEDCT_US_2016_03_01:191705007|UMLS_CUI:C0030319|OMIM:609985|OMIM:167870|MESH:D016584|SNOMEDCT_US_2016_03_01:192400001|EFO:0004262|SNOMEDCT_US_2016_03_01:371631005|OMIM:607853|NCI:C34890,panic anxiety syndrome,,disease_ontology,,DOID:594,,,,,,,,,,,,,,,,,Xref MGI.,,panic disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_593,"[""agoraphobia""]",,A phobic disorder involving the specific anxiety about being in a place or situation where escape is difficult or embarrassing or where help may be unavailable.,false,,,http://purl.obolibrary.org/obo/DOID_591,,,,,,,,A phobic disorder involving the specific anxiety about being in a place or situation where escape is difficult or embarrassing or where help may be unavailable.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:593,,,,ICD10CM:F40.00|SNOMEDCT_US_2016_03_01:247830007|UMLS_CUI:C0001818|SNOMEDCT_US_2016_03_01:70691001|MESH:D000379|SNOMEDCT_US_2016_03_01:154885006|SNOMEDCT_US_2016_03_01:192394003|ICD10CM:F40.0|NCI:C34362,Fear of open spaces (finding),,disease_ontology,,DOID:593,,,,,,,,,,,,,,,,,,,agoraphobia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200527,"[""TTN gene""]",,"This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma. [provided by RefSeq, Feb 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400196,,,,,,,,"This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma. [provided by RefSeq, Feb 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200527,,,,,,,,,,,,,,,,7273,TTN,,,,,,,,,,,TTN gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2914,"[""immune system disease""]",,A disease of anatomical entity that is located_in the immune system.,false,,,http://purl.obolibrary.org/obo/DOID_7,,,,,,,,A disease of anatomical entity that is located_in the immune system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2914,,,,SNOMEDCT_US_2016_03_01:191019003|EFO:0000540|UMLS_CUI:C0041806|SNOMEDCT_US_2016_03_01:191035005|SNOMEDCT_US_2016_03_01:191015009|ICD9CM:279.9|SNOMEDCT_US_2016_03_01:154782004|ICD9CM:279|ICD10CM:D89.9,,,disease_ontology,,DOID:2914,http://purl.obolibrary.org/obo/doid#DO_MGI_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,immune system disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100371,"[""Olfactory receptor 2t27""]",,"An olfactory receptor 2T27 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH04] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2T27 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH04] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100371,,,,https://pharos.nih.gov/idg/targets/Q8NH04,,,,,,,,,,,,,OR2T27,,,Q8NH04,,,,,,,,Olfactory receptor 2t27,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000109,"[""DCAMKL3 kinase domain""]",,Doublecortin-like kinase 3; CLR; DCAMKL3; DCDC3C; DCK3; DCLK3; KIAA1765,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Doublecortin-like kinase 3; CLR; DCAMKL3; DCDC3C; DCK3; DCLK3; KIAA1765,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000109,,,,,,,,,,,,,,,,,,,200111,,,,,,,,,DCAMKL3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100007,"[""D559 and A654 in KIT(V559D,V654A)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100007,,,,,,,,,,,,,,,,,,,,,,,,,,,,"D559 and A654 in KIT(V559D,V654A)",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000079,"[""CDK5 kinase domain""]",,Cyclin-dependent kinase 5; cell division protein kinase 5; PSSALRE,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Cyclin-dependent kinase 5; cell division protein kinase 5; PSSALRE,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000079,,,,,,,,,,,,,,,,,,,200079,,,,,,,,,CDK5 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3959,"[""adrenal cortical adenocarcinoma""]",,An adrenalcortical carcinoma that originating in the cortex of the adrenal gland and derives_from epithelial cells of glandular origin.,false,,,http://purl.obolibrary.org/obo/DOID_3948|http://purl.obolibrary.org/obo/DOID_299,,,,,,,,An adrenalcortical carcinoma that originating in the cortex of the adrenal gland and derives_from epithelial cells of glandular origin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3959,,,,,Adrenal cortex adenocarcinoma|Adrenal cortical adenocarcinoma,,disease_ontology,,DOID:3959,,,,,,,,,,,,,,,,,,,adrenal cortical adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2224,"[""essential thrombocythemia""]",,"A myeloproliferative neoplasm that is characterized by sustained thrombocytosis in the blood, increased numbers of large, mature megakaryocytes in the bone marrow, and episodes of thrombosis and/or hemorrhage and that results_in the overproduction of platelets.",false,,,http://purl.obolibrary.org/obo/DOID_2226,,,,,,,,"A myeloproliferative neoplasm that is characterized by sustained thrombocytosis in the blood, increased numbers of large, mature megakaryocytes in the bone marrow, and episodes of thrombosis and/or hemorrhage and that results_in the overproduction of platelets.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2224,,,,OMIM:300331|OMIM:601977|SNOMEDCT_US_2016_03_01:65471002|ORDO:71493|SNOMEDCT_US_2016_03_01:191333009|SNOMEDCT_US_2016_03_01:234499005|SNOMEDCT_US_2016_03_01:128844009|NCI:C3407|SNOMEDCT_US_2016_03_01:189508006|OMIM:187950|ICD10CM:D47.3|SNOMEDCT_US_2016_03_01:109994006|MESH:D013920|ORDO:3318|ICD9CM:238.71|OMIM:614521|SNOMEDCT_US_2016_03_01:189514004|SNOMEDCT_US_2016_03_01:189513005|SNOMEDCT_US_2016_03_01:307652003|UMLS_CUI:C0040028,hemorrhagic thrombocythemia|hereditary thrombocythemia|primary Thrombocytosis|familial thrombocytosis|Essential thrombocythaemia,,disease_ontology,,DOID:2224,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,essential thrombocythemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100538,"[""Triple functional domain protein""]",,"A triple functional domain protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75962] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300168,,,,,,,,"A triple functional domain protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75962] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100538,,,,https://pharos.nih.gov/idg/targets/O75962,,,,,,,,,,,,,TRIO,,,O75962,,,,,,,,Triple functional domain protein,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400579,"[""TRPC4 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400482,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400579,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPC4 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217565,"[""ESRRG gene""]",,"This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_00217473,,,,,,,,"This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217565,,,,,,,,,,,,,,,,2104,ESRRG,ERR3|ERRG2|KIAA0832,,,,,,,,,,ESRRG gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400476,"[""Nav1.9/SCN11A subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400369,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400476,,,,,,,,,,,,,,,,,,,,,,,,,,,,Nav1.9/SCN11A subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002690,"[""biofilm""]",,A thin usually resistant layer of microorganisms (as bacteria) that form on and coat various surfaces (as of water pipes and catheters).,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000284,,,,,,,,A thin usually resistant layer of microorganisms (as bacteria) that form on and coat various surfaces (as of water pipes and catheters).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002690,,,,,,,BrendaTissueOBO,,BTO:0002690,,,,,,,,,,,,,,,,,,,biofilm,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400318,"[""TAO subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400187,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400318,,,,,,,,,,,,,,,,,,,,,,,,,,,,TAO subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000299,"[""cotton fibre""]",,"Each seed of a cotton plant is surrounded with downy fiber, white or creamy in color and easily spun. The fibers flatten and twist naturally as they dry.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000450,,,,,,,,"Each seed of a cotton plant is surrounded with downy fiber, white or creamy in color and easily spun. The fibers flatten and twist naturally as they dry.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000299,,,,,,,BrendaTissueOBO,cotton fiber,BTO:0000299,,,,,,,,,,,,,,,,,,,cotton fibre,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100238,"[""Lysophosphatidic acid receptor 1""]",,"A lysophosphatidic acid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q92633] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302007,,,,,,,,"A lysophosphatidic acid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q92633] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100238,,,,https://pharos.nih.gov/idg/targets/Q92633,,,,,,,,,,,,,LPAR1,EDG2|LPA1,,Q92633,,,,,,,,Lysophosphatidic acid receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000203,"[""SRIF-28""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000203,,,,,,,,,,,,,,,,,,,,,,,,,,,,SRIF-28,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00000013,"[""inorganic ion GPCR ligand""]",,A GPCR ligand that is classified as inorganic ion in CHEBI.,false,,,http://www.drugtargetontology.org/dto/DTO_00000001|http://purl.obolibrary.org/obo/CHEBI_36914,,,,,,,,A GPCR ligand that is classified as inorganic ion in CHEBI.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00000013,,,,,,,,,,,,,,,,,,,,,,,,,,,Asiyah Yu Lin,inorganic ion GPCR ligand,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200269,"[""AATK gene""]",,"The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400183,,,,,,,,"The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200269,,,,,,,,,,,,,,,,9625,AATK,AATYK|KIAA0641|LMR1,,,,,,,,,,AATK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5223,"[""infertility""]",,,false,,,http://purl.obolibrary.org/obo/DOID_15,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5223,,,,SNOMEDCT_US_2016_03_01:289179008|SNOMEDCT_US_2016_03_01:8619003|NCI:C3836|UMLS_CUI:C0021359|SNOMEDCT_US_2016_03_01:15296000|MESH:D007246|SNOMEDCT_US_2016_03_01:162186008,,,disease_ontology,,DOID:5223,,,,,,,,,,,,,,,,,,,infertility,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000377,"[""THR674 in PGFRA""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000377,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR674 in PGFRA,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004230,"[""TM-4 cell""]",,Mouse testicular Sertoli cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0004513,,,,,,,,Mouse testicular Sertoli cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004230,,,,,,,BrendaTissueOBO,TM4 cell,BTO:0004230,,,,,,,,,,,,,,,,,,,TM-4 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200099,"[""FAM26E gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400347,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200099,,,,,,,,,,,,,,,,254228,FAM26E,C6orf188,,,,,,,,,,FAM26E gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/UBERON_0001043,"[""esophagus""]",Åsophagus,"Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993).",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,http://linkedlifedata.com/resource/umls/id/C0014876|http://www.snomedbrowser.com/Codes/Details/181245004|http://en.wikipedia.org/wiki/Esophagus|EMAPA:18860|TAO:0000204|MAT:0000048|EFO:0000835|AAO:0000145|EMAPA:16833|VHOG:0000450|UMLS:C0014876|OpenCyc:Mx4rvVj9Q5wpEbGdrcN5Y29ycA|MA:0000352|EHDAA2:0001285|EHDAA:2937|galen:Esophagus|FMA:7131|ncithesaurus:Esophagus|ANISEED:1235301|BTO:0000959|GAID:291|CALOHA:TS-0700|XAO:0000127|MESH:A03.365|EV:0100069|MIAA:0000048|ZFA:0000204,"Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993).",,http://upload.wikimedia.org/wikipedia/commons/d/d4/Illu01_head_neck.jpg,,,,,,,,Anterior end of the alimentary canal lined with smooth muscle. Bounded anteriorly by a constriction in the pharynx. Bounded posteriorly by and increase in circular and/or longitudinal smooth muscle associated with the stomach.[AAO],,,,,,,,,,,,,,,,,,,,,,,,,,oesophagus|gullet,,uberon,Åsophagus,esophageal,"The few structural specializations in (adult lampreys) pharynx include complex valves on the external gill openings that direct the tidal flow, and the division of the ancestral pharynx into an oesophagus and a respiratory pharynx.[well established][VHOG]",,,,,,,,,,,,,,,,,,,,,,,,UBERON:0001043,,,"AO notes: esophagus NOT part of gut in MA. part of gut in ZFA. part_of gut (via UGIT) in FMA. Consider splitting. Interspecies:  The human oesophagus is 25 cm long and has a diameter of ca. 2 cm. Only little information was found on the oesophagus in rat, rabbit and pig. The oesophagus of rat (75 x 2 mm) and rabbit has no mucous glands and the cardia of the stomach has a well-developed sphincter, which prevents them from vomiting (Hebel and Stromberg, 1988; Manning et al., 1994). Morphologically the oesophagus is similar in man and pig; both are omnivores and have a non-keratinised epithelium, submucous glands and similar membrane enzymes. Like in humans, pigs can suffer from reflux oesophagitis and stress ulceration of the oesophagus. The pig oesophagus may therefore be a good model for investigation compared to the human oesophagus (Christie et al., 1995)",,esophagus,,UBERON:0001043,,http://purl.obolibrary.org/obo/uberon.owl,http://purl.obolibrary.org/obo/uberon/core#efo_slim|http://purl.obolibrary.org/obo/uberon/core#organ_slim|http://purl.obolibrary.org/obo/uberon/core#vertebrate_core|http://purl.obolibrary.org/obo/uberon/core#major_organ|http://purl.obolibrary.org/obo/uberon/core#uberon_slim,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400440,"[""KCNMB/KCNMB3 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400358,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400440,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNMB/KCNMB3 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060233,"[""cardiofaciocutaneous syndrome""]",,"A syndrome characterized by unusually sparse, brittle, curly hair, macrocephaly, a prominent forehead and bi-temporal narrowing, intellectual disability, failure to thrive, congenital heart defects, short stature and skin abnormalities; it is that has material basis in mutation in the BRAF, MAP2K1, MAP2kK2 and KRAS genes.",false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,"A syndrome characterized by unusually sparse, brittle, curly hair, macrocephaly, a prominent forehead and bi-temporal narrowing, intellectual disability, failure to thrive, congenital heart defects, short stature and skin abnormalities; it is that has material basis in mutation in the BRAF, MAP2K1, MAP2kK2 and KRAS genes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060233,emitraka,2015-01-23T15:37:07Z,,OMIM:615279|OMIM:615278|OMIM:615280|ORDO:1340|OMIM:115150|ICD10CM:Q87.8,cardio-facial-cutaneous syndrome|CFC syndrome,,disease_ontology,,DOID:0060233,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,NT MGI.,,cardiofaciocutaneous syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060237,"[""Warburg micro syndrome""]",,"An autosomal recessive disease characterized by severe intellectual disability, microcephaly, congenital cataract, microcornea, microphthalmia, agenesis or hypoplasia of the corpus callosum and hypogenitalism.",false,,,http://purl.obolibrary.org/obo/DOID_0050737,,,,,,,,"An autosomal recessive disease characterized by severe intellectual disability, microcephaly, congenital cataract, microcornea, microphthalmia, agenesis or hypoplasia of the corpus callosum and hypogenitalism.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060237,emitraka,2015-01-27T14:32:30Z,,OMIM:PS600118|ORDO:2510|MESH:C536681|UMLS_CUI:C1838625,WARBM|Warburg-Sjo-Fledelius syndrome|micro syndrome,,disease_ontology,,DOID:0060237,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,NT MGI.,,Warburg micro syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060230,"[""basal ganglia calcification""]",,"A basal ganglia disease characterized by the presence of abnormal calcium deposits of unknown cause in the brain; has symptom dementia, psychosis, mood swings and loss of acquired motor skills.",false,,,http://purl.obolibrary.org/obo/DOID_679,,,,,,,,"A basal ganglia disease characterized by the presence of abnormal calcium deposits of unknown cause in the brain; has symptom dementia, psychosis, mood swings and loss of acquired motor skills.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060230,emitraka,2015-01-22T13:09:08Z,,UMLS_CUI:C0393590|OMIM:615483|OMIM:606656|OMIM:615007|HP:0002135|OMIM:213600|MESH:C536275|SNOMEDCT_US_2016_03_01:110997000|OMIM:114100,Fahr disease,,disease_ontology,,DOID:0060230,,,,,,,,,,,,,,,,,NT MGI.,,basal ganglia calcification,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1883,"[""hepatitis C""]",,"A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis C virus, which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.",false,,,http://purl.obolibrary.org/obo/DOID_37|http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis C virus, which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1883,,,DOID:2049|DOID:12430|DOID:12432,MESH:D019698|ICD10CM:B19.2|SNOMEDCT_US_2016_03_01:186643004|SNOMEDCT_US_2016_03_01:50711007|ICD10CM:B19.20|NCI:C3098|MESH:D006526|ICD9CM:070.7|SNOMEDCT_US_2016_03_01:154349000|SNOMEDCT_US_2016_03_01:186634008|UMLS_CUI:C0019196|EFO:0003047|SNOMEDCT_US_2016_03_01:123324009,chronic hepatitis C|hepatitis nonA nonB|hepatitis C infection|NANBH|Viral hepatitis C,,disease_ontology,,DOID:1883,,,,,,,,,,,,,,,,,,,hepatitis C,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200424,"[""OR52J3 gene""]",,"An olfactory receptor 52J3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH60] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 52J3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH60] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200424,,,,,,,,,,,,,,,,119679,OR52J3,,,,,,,,,,,OR52J3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200280,"[""PKD2 gene""]",,"This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq, Mar 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400367,,,,,,,,"This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq, Mar 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200280,,,,,,,,,,,,,,,,5311,PKD2,,,,,,,,,,,PKD2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9368,"[""keratoconjunctivitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5614,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9368,,,DOID:9367,ICD10CM:H16.2|NCI:C34744|ICD9CM:370.40|ICD10CM:H16.20|SNOMEDCT_US_2016_03_01:193757003|SNOMEDCT_US_2016_03_01:88151007|SNOMEDCT_US_2016_03_01:155154005|UMLS_CUI:C0022573|MESH:D007637|SNOMEDCT_US_2016_03_01:193780006,,,disease_ontology,,DOID:9368,,,,,,,,,,,,,,,,,,,keratoconjunctivitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200150,"[""GPR146 gene""]",,"A G-protein coupled receptor 146 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96CH1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 146 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96CH1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200150,,,,,,,,,,,,,,,,115330,GPR146,PGR8,,,,,,,,,,GPR146 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200609,"[""NME5 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200609,,,,,,,,,,,,,,,,,,,,,,,,,,,,NME5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100038,"[""M790 in EGFR(T790M)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100038,,,,,,,,,,,,,,,,,,,,,,,,,,,,M790 in EGFR(T790M),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100564,"[""Inactive serine/threonine-protein kinase vrk3""]",,"An inactive serine/threonine-protein kinase VRK3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IV63] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300243,,,,,,,,"An inactive serine/threonine-protein kinase VRK3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IV63] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100564,,,,https://pharos.nih.gov/idg/targets/Q8IV63,,,,,,,,,,,,,VRK3,,,Q8IV63,,,,,,,,Inactive serine/threonine-protein kinase vrk3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200789,"[""TAS2R43 gene""]",,"A taste receptor type 2 member 43 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59537] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400014,,,,,,,,"A taste receptor type 2 member 43 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59537] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200789,,,,,,,,,,,,,,,,259289,TAS2R43,,,,,,,,,,,TAS2R43 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400394,"[""CLCNKB subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400341,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400394,,,,,,,,,,,,,,,,,,,,,,,,,,,,CLCNKB subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400043,"[""Frizzled receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400005,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400043,,,,,,,,,,,,,,,,,,,,,,,,,,,,Frizzled receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400314,"[""QIK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400116,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400314,,,,,,,,,,,,,,,,,,,,,,,,,,,,QIK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100810,"[""Taste receptor type 1 member 1""]",,"A taste receptor type 1 member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7RTX1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300015,,,,,,,,"A taste receptor type 1 member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7RTX1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100810,,,,https://pharos.nih.gov/idg/targets/Q7RTX1,,,,,,,,,,,,,TAS1R1,GPR70|T1R1|TR1,,Q7RTX1,,,,,,,,Taste receptor type 1 member 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/UBERON_0000310,"[""breast""]",mamma,"The breast is the upper ventral region of an animal's torso, particularly that of mammals, including human beings. The breasts of a female primate’s body contain the mammary glands, which secrete milk used to feed infants. Both men and women develop breasts from the same embryological tissues. However, at puberty female sex hormones, mainly estrogens, promote breast development, which does not happen with men. As a result women's breasts become more prominent than men's. [WP,unvetted].",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000254|http://purl.obolibrary.org/obo/BTO_0000431|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,http://en.wikipedia.org/wiki/Breast|http://www.snomedbrowser.com/Codes/Details/181131000|http://linkedlifedata.com/resource/umls/id/C0006141|OpenCyc:Mx4rvVjV7ZwpEbGdrcN5Y29ycA|CALOHA:TS-2083|BTO:0000149|MESH:A01.236|FMA:9601|EV:0100124|UMLS:C0006141|galen:Breast|ncithesaurus:Breast|GAID:33,"The breast is the upper ventral region of an animal's torso, particularly that of mammals, including human beings. The breasts of a female primate’s body contain the mammary glands, which secrete milk used to feed infants. Both men and women develop breasts from the same embryological tissues. However, at puberty female sex hormones, mainly estrogens, promote breast development, which does not happen with men. As a result women's breasts become more prominent than men's. [WP,unvetted].",,http://upload.wikimedia.org/wikipedia/commons/6/6e/Closeup_of_female_breast.jpg|http://upload.wikimedia.org/wikipedia/commons/thumb/6/6e/Closeup_of_female_breast.jpg/200px-Closeup_of_female_breast.jpg,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,mammary part of chest|mammary region,,uberon,mamma,,,,,,,,,,,,,,,,,,,,,,,,,,UBERON:0000310,,,,,breast,,UBERON:0000310,,http://purl.obolibrary.org/obo/uberon.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200391,"[""OR51D1 gene""]",,"An olfactory receptor 51D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 51D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200391,,,,,,,,,,,,,,,,390038,OR51D1,,,,,,,,,,,OR51D1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13934,"[""facial paralysis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1756,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13934,,,,SNOMEDCT_US_2016_03_01:79359001|SNOMEDCT_US_2016_03_01:155070005|MESH:D005158|ICD10CM:G51.0|SNOMEDCT_US_2016_03_01:90039006|NCI:C26769|SNOMEDCT_US_2016_03_01:280816001|SNOMEDCT_US_2016_03_01:46382007|SNOMEDCT_US_2016_03_01:267703001|UMLS_CUI:C0015469,Facial Palsy,,disease_ontology,,DOID:13934,,,,,,,,,,,,,,,,,,,facial paralysis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13938,"[""amenorrhea""]",,,false,,,http://purl.obolibrary.org/obo/DOID_229,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13938,,,,SNOMEDCT_US_2016_03_01:14302001|NCI:C61443|SNOMEDCT_US_2016_03_01:156037007|SNOMEDCT_US_2016_03_01:156034000|ICD10CM:N91.2|UMLS_CUI:C0002453|MESH:D000568|SNOMEDCT_US_2016_03_01:198414005|ICD9CM:626.0,amenia|absence of menstruation,,disease_ontology,,DOID:13938,,,,,,,,,,,,,,,,,,,amenorrhea,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1088,"[""meningocele""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0080016,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1088,,,,SNOMEDCT_US_2016_03_01:32941003|SNOMEDCT_US_2016_03_01:171131006|MESH:D008588|SNOMEDCT_US_2016_03_01:156890007|SNOMEDCT_US_2016_03_01:253121009|SNOMEDCT_US_2016_03_01:268308005|UMLS_CUI:C0025299,,,disease_ontology,,DOID:1088,,,,,,,,,,,,,,,,,,,meningocele,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400542,"[""Kv3.2/KCNC2 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400443,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400542,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv3.2/KCNC2 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200528,"[""TLK1 gene""]",,"The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400235,,,,,,,,"The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200528,,,,,,,,,,,,,,,,9874,TLK1,KIAA0137,,,,,,,,,,TLK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300112,"[""CK1 group""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300102,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300112,,,,,,,,,,,,,,,,,,,,,,,,,,,,CK1 group,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003000,"[""EB-1 cell""]",,Human Burkitt lymphoma cell line; established from the maxilla tumor lymph node of a 9-year-old black girl with Burkitt lymphoma in 1964; cells were described to be EBV-positive.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000889,,,,,,,,Human Burkitt lymphoma cell line; established from the maxilla tumor lymph node of a 9-year-old black girl with Burkitt lymphoma in 1964; cells were described to be EBV-positive.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003000,,,,,,,BrendaTissueOBO,EB1 cell,BTO:0003000,,,,,,,,,,,,,,,,,,,EB-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000379,"[""THR687 in TYK2(JH1domain-catalytic)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000379,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR687 in TYK2(JH1domain-catalytic),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300051,"[""LU7TM family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300051,,,,,,,,,,,,,,,,,,,,,,,,,,,,LU7TM family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100287,"[""Neurotensin receptor type 2""]",,"A neurotensin receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95665] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300072,,,,,,,,"A neurotensin receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95665] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100287,,,,https://pharos.nih.gov/idg/targets/O95665,,,,,,,,,,,,,NTSR2,,,O95665,,,,,,,,Neurotensin receptor type 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4607,"[""biliary tract cancer""]",,A gastrointestinal system cancer that results_in malignant growth located_in the gallbladder or located_in the bile duct.,false,,,http://purl.obolibrary.org/obo/DOID_9741|http://purl.obolibrary.org/obo/DOID_3119,,,,,,,,A gastrointestinal system cancer that results_in malignant growth located_in the gallbladder or located_in the bile duct.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4607,,,DOID:8092,MESH:D001661|UMLS_CUI:C0005426|SNOMEDCT_US_2016_03_01:126853008|ICD9CM:156.9|UMLS_CUI:C0750952|SNOMEDCT_US_2016_03_01:363415003|ICD10CM:C24.9|SNOMEDCT_US_2016_03_01:93688006,malignant tumour of biliary tract,,disease_ontology,,DOID:4607,,,,,,,,,,,,,,,,,,,biliary tract cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004286,"[""basophilic leukemia cell""]",,A rare type of leukemia in which basophils predominate; both acute and chronic varieties have been observed.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001271,,,,,,,,A rare type of leukemia in which basophils predominate; both acute and chronic varieties have been observed.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004286,,,,,,,BrendaTissueOBO,,BTO:0004286,,,,,,,,,,,,,,,,,,,basophilic leukemia cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300538,"[""Kv1.7/KCNA7 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300436,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300538,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv1.7/KCNA7 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400582,"[""TRPC7 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400482,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400582,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPC7 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000449,"[""fetus""]",,An unborn or unhatched vertebrate especially after attaining the basic structural plan of its kind; specifically: a developing human from usually three months after conception to birth.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000174,,,,,,,,An unborn or unhatched vertebrate especially after attaining the basic structural plan of its kind; specifically: a developing human from usually three months after conception to birth.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000449,,,,,,,BrendaTissueOBO,embryo late stage|embryo late growth stage,BTO:0000449,,,,,,,,,,,,,,,,,,,fetus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4159,"[""skin cancer""]",,An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells.,false,,,http://purl.obolibrary.org/obo/DOID_0060122,,,,,,,,An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4159,,,,UMLS_CUI:C0007114|NCI:C2920|SNOMEDCT_US_2016_03_01:363511009|SNOMEDCT_US_2016_03_01:188143008|SNOMEDCT_US_2016_03_01:94047004|SNOMEDCT_US_2016_03_01:372130007|SNOMEDCT_US_2016_03_01:190107001|MESH:D012878,melanoma and Non-melanoma skin cancer|CA - skin cancer|malignant neoplasm of skin,,disease_ontology,cancer of skin,DOID:4159,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,skin cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200322,"[""TRPC4 gene""]",,"This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400579,,,,,,,,"This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200322,,,,,,,,,,,,,,,,7223,TRPC4,,,,,,,,,,,TRPC4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5395,"[""functioning pituitary adenoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3829,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5395,,,,UMLS_CUI:C0854486|NCI:C8388,Secretory adenoma of the Pituitary gland,,disease_ontology,,DOID:5395,,,,,,,,,,,,,,,,,,,functioning pituitary adenoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200229,"[""KCNN2 gene""]",,"Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_01400437,,,,,,,,"Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200229,,,,,,,,,,,,,,,,3781,KCNN2,,,,,,,,,,,KCNN2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000275,"[""PHE691 in FLT3(R834Q)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000275,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE691 in FLT3(R834Q),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100231,"[""Mast/stem cell growth factor receptor kit""]",,"mast/stem cell growth factor receptor kit (KIT-autoinhibited)  with  no mutation  in a nonphosphorylated state|mast/stem cell growth factor receptor kit (KIT(L576P))  with  mutation P576 in KIT(L576P) in a nonphosphorylated state|mast/stem cell growth factor receptor kit (KIT)  with  no mutation  in a nonphosphorylated state|mast/stem cell growth factor receptor kit (KIT(A829P))  with  mutation P829 in KIT(A829P) in a nonphosphorylated state|mast/stem cell growth factor receptor kit (KIT(D816V))  with  mutation V816 in KIT(D816V) in a nonphosphorylated state|A mast/stem cell growth factor receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P10721] |mast/stem cell growth factor receptor kit (KIT(D816H))  with  mutation H816 in KIT(D816H) in a nonphosphorylated state|mast/stem cell growth factor receptor kit (KIT(V559D))  with  mutation D559 in KIT(V559D) in a nonphosphorylated state|mast/stem cell growth factor receptor kit (KIT(V559D,V654A))  with  mutation D559 and A654 in KIT(V559D,V654A) in a nonphosphorylated state|mast/stem cell growth factor receptor kit (KIT(V559D,T670I))  with  mutation D559 and I670 in KIT(V559D,T670I) in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300141,,,,,,,,"mast/stem cell growth factor receptor kit (KIT-autoinhibited)  with  no mutation  in a nonphosphorylated state|mast/stem cell growth factor receptor kit (KIT(L576P))  with  mutation P576 in KIT(L576P) in a nonphosphorylated state|mast/stem cell growth factor receptor kit (KIT)  with  no mutation  in a nonphosphorylated state|mast/stem cell growth factor receptor kit (KIT(A829P))  with  mutation P829 in KIT(A829P) in a nonphosphorylated state|mast/stem cell growth factor receptor kit (KIT(D816V))  with  mutation V816 in KIT(D816V) in a nonphosphorylated state|A mast/stem cell growth factor receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P10721] |mast/stem cell growth factor receptor kit (KIT(D816H))  with  mutation H816 in KIT(D816H) in a nonphosphorylated state|mast/stem cell growth factor receptor kit (KIT(V559D))  with  mutation D559 in KIT(V559D) in a nonphosphorylated state|mast/stem cell growth factor receptor kit (KIT(V559D,V654A))  with  mutation D559 and A654 in KIT(V559D,V654A) in a nonphosphorylated state|mast/stem cell growth factor receptor kit (KIT(V559D,T670I))  with  mutation D559 and I670 in KIT(V559D,T670I) in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100231,,,,https://pharos.nih.gov/idg/targets/P10721,,,,,,,,,,,,,KIT,SCFR,,P10721,,,,,,,,Mast/stem cell growth factor receptor kit,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300416,"[""GRIK1 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300416,,,,,,,,,,,,,,,,,,,,,,,,,,,,GRIK1 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4022,"[""ureterocele""]",,OMIM mapping confirmed by DO. [LS].,false,,,http://purl.obolibrary.org/obo/DOID_1426,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4022,,,,NCI:C123159|MESH:D014518|SNOMEDCT_US_2016_03_01:12818004|OMIM:191650|UMLS_CUI:C0041960,,,disease_ontology,,DOID:4022,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,ureterocele,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2664,"[""sweat gland neoplasm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3165,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2664,,,,SNOMEDCT_US_2016_03_01:126490003|NCI:C3398|UMLS_CUI:C0038987|SNOMEDCT_US_2016_03_01:189665000|MESH:D013544|SNOMEDCT_US_2016_03_01:12933008,Sweat gland tumor (morphologic abnormality)|Sweat gland tumor NOS (morphologic abnormality)|tumor of the Sweat gland|neoplasm of sweat gland (disorder),,disease_ontology,,DOID:2664,,,,,,,,,,,,,,,,,,,sweat gland neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_176,"[""cardiovascular cancer""]",,An organ system cancer that located_in the heart and blood vessels.,false,,,http://purl.obolibrary.org/obo/DOID_0050686|http://purl.obolibrary.org/obo/DOID_1287,,,,,,,,An organ system cancer that located_in the heart and blood vessels.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:176,,,,UMLS_CUI:C0497243|NCI:C4784,Cardiovascular tumors|cardiovascular neoplasm,,disease_ontology,,DOID:176,,,,,,,,,,,,,,,,,,,cardiovascular cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_17,"[""musculoskeletal system disease""]",,A disease of anatomical entity that occurs in the muscular and/or skeletal system.,false,,,http://purl.obolibrary.org/obo/DOID_7,,,,,,,,A disease of anatomical entity that occurs in the muscular and/or skeletal system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:17,,,,SNOMEDCT_US_2016_03_01:156881000|MESH:D009140|SNOMEDCT_US_2016_03_01:268142006|SNOMEDCT_US_2016_03_01:268047003|SNOMEDCT_US_2016_03_01:274149006|SNOMEDCT_US_2016_03_01:928000|NCI:C107377|UMLS_CUI:C0026857,,,disease_ontology,,DOID:17,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,musculoskeletal system disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_171,"[""neuroectodermal tumor""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3093,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:171,,,,SNOMEDCT_US_2016_03_01:253096008|MESH:D017599|SNOMEDCT_US_2016_03_01:73676002|UMLS_CUI:C0206093,primitive Neuroectodermal neoplasm,,disease_ontology,,DOID:171,,,,,,,,,,,,,,,,,,,neuroectodermal tumor,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_178,"[""vascular disease""]",,"A cardiovascular system disease that primarily affects the blood vessels which includes the arteries, veins and capillaries that carry blood to and from the heart.",false,,,http://purl.obolibrary.org/obo/DOID_1287,,,,,,,,"A cardiovascular system disease that primarily affects the blood vessels which includes the arteries, veins and capillaries that carry blood to and from the heart.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:178,,,DOID:325|DOID:324|DOID:2869|DOID:45|DOID:0000405|DOID:2403,SNOMEDCT_US_2016_03_01:362727005|SNOMEDCT_US_2016_03_01:371029002|SNOMEDCT_US_2016_03_01:195292009|NCI:C35117|NCI:C26693|MESH:D020758|UMLS_CUI:C0002940|UMLS_CUI:C0042373|MESH:D020760|SNOMEDCT_US_2016_03_01:134342004|MESH:D000783|SNOMEDCT_US_2016_03_01:85659009|ICD9CM:442.9|ICD10CM:I72.9|SNOMEDCT_US_2016_03_01:27550009|SNOMEDCT_US_2016_03_01:155428007|MESH:D014652|SNOMEDCT_US_2016_03_01:155425005|UMLS_CUI:C0752127|SNOMEDCT_US_2016_03_01:432119003|UMLS_CUI:C0752130,vascular tissue disease,,disease_ontology,,DOID:178,,,,,,,,,,,,,,,,,,,vascular disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_170,"[""endocrine gland cancer""]",,An organ system cancer located_in endocrine system that is characterized by uncontrolled cellular proliferation of the hormone producing glands of the endocrine system.,false,,,http://purl.obolibrary.org/obo/DOID_0050686|http://purl.obolibrary.org/obo/DOID_28,,,,,,,,An organ system cancer located_in endocrine system that is characterized by uncontrolled cellular proliferation of the hormone producing glands of the endocrine system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:170,,,DOID:10009,UMLS_CUI:C0014132|SNOMEDCT_US_2016_03_01:93780007|SNOMEDCT_US_2016_03_01:371982006|ICD9CM:194.9|SNOMEDCT_US_2016_03_01:363347009|NCI:C3575|ICD10CM:C75.9|MESH:D004701|SNOMEDCT_US_2016_03_01:127015005|SNOMEDCT_US_2016_03_01:387927001|UMLS_CUI:C0153658|SNOMEDCT_US_2016_03_01:387922007|SNOMEDCT_US_2016_03_01:190140005|NCI:C3010,neoplasm of endocrine system (disorder)|malignant neoplasm of endocrine gland|Endocrine tumor|endocrine neoplasm|malignant tumour of endocrine gland|malignant Endocrine tumor|neoplasm of endocrine gland (disorder),,disease_ontology,,DOID:170,http://purl.obolibrary.org/obo/doid#DO_MGI_slim|http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,endocrine gland cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100028,"[""Alpha-1B adrenergic receptor""]",,"An alpha-1B adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35368] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300093,,,,,,,,"An alpha-1B adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35368] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100028,,,,https://pharos.nih.gov/idg/targets/P35368,,,,,,,,,,,,,ADRA1B,,,P35368,,,,,,,,Alpha-1B adrenergic receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200366,"[""NLK gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400300,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200366,,,,,,,,,,,,,,,,51701,NLK,LAK1,,,,,,,,,,NLK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4540,"[""dysgraphia""]",,"A writing disorder that involves a deficiency in the ability to write where the writing is distorted or incorrect, spelling difficulty, poor handwriting or trouble putting thoughts on paper.",false,,,http://purl.obolibrary.org/obo/DOID_0060047,,,,,,,,"A writing disorder that involves a deficiency in the ability to write where the writing is distorted or incorrect, spelling difficulty, poor handwriting or trouble putting thoughts on paper.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4540,,,,ICD10CM:R48.8|SNOMEDCT_US_2016_03_01:27206009|UMLS_CUI:C0001825|SNOMEDCT_US_2016_03_01:158321001|SNOMEDCT_US_2016_03_01:206990000|MESH:D000381,,,disease_ontology,,DOID:4540,,,,,,,,,,,,,,,,,,,dysgraphia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100305,"[""Olfactory receptor 10G8""]",,"An olfactory receptor 10G8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10G8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100305,,,,https://pharos.nih.gov/idg/targets/Q8NGN5,,,,,,,,,,,,,OR10G8,,,Q8NGN5,,,,,,,,Olfactory receptor 10G8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100478,"[""Olfactory receptor 1A2""]",,"An olfactory receptor 1A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y585] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y585] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100478,,,,https://pharos.nih.gov/idg/targets/Q9Y585,,,,,,,,,,,,,OR1A2,,,Q9Y585,,,,,,,,Olfactory receptor 1A2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100013,"[""G808 in GCN2(Kin.Dom.2,S808G)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100013,,,,,,,,,,,,,,,,,,,,,,,,,,,,"G808 in GCN2(Kin.Dom.2,S808G)",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200163,"[""KCNJ8 gene""]",,"Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS). [provided by RefSeq, May 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400434,,,,,,,,"Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS). [provided by RefSeq, May 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200163,,,,,,,,,,,,,,,,3764,KCNJ8,,,,,,,,,,,KCNJ8 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200179,"[""ICK gene""]",,"Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400162,,,,,,,,"Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200179,,,,,,,,,,,,,,,,22858,ICK,KIAA0936,,,,,,,,,,ICK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300564,"[""Kv7.4/KCNQ4 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300449,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300564,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv7.4/KCNQ4 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000129,"[""basophil""]",,Mammalian granulocyte with large heterochromatic basophilic granules that contain histamine bound to a protein and heparin-like mucopolysaccharide matrix. They are not phagocytic. Very similar to mast cells though it is not clear whether they have common lineage.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000539,,,,,,,,Mammalian granulocyte with large heterochromatic basophilic granules that contain histamine bound to a protein and heparin-like mucopolysaccharide matrix. They are not phagocytic. Very similar to mast cells though it is not clear whether they have common lineage.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000129,,,,,,,BrendaTissueOBO,basophil granulocyte|basophilic leucocyte|basophilic leukocyte,BTO:0000129,,,,,,,,,,,,,,,,,,,basophil,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1059,"[""intellectual disability""]",,"A specific developmental disorder that involves significant limitations both in mental functioning and in adaptive behavior such as communicating, taking care of him or herself, and social skills.",false,,,http://purl.obolibrary.org/obo/DOID_0060038,,,,,,,,"A specific developmental disorder that involves significant limitations both in mental functioning and in adaptive behavior such as communicating, taking care of him or herself, and social skills.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1059,,,,SNOMEDCT_US_2016_03_01:154979000|NCI:C84392|SNOMEDCT_US_2016_03_01:268732001|SNOMEDCT_US_2016_03_01:192157003|UMLS_CUI:C0025362|SNOMEDCT_US_2016_03_01:91138005|SNOMEDCT_US_2016_03_01:154978008|SNOMEDCT_US_2016_03_01:1855002|SNOMEDCT_US_2016_03_01:192557008,"MENTAL RETARDATION, AUTOSOMAL RECESSIVE 15",,disease_ontology,mental retardation,DOID:1059,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping submitted by NeuroDevNet. [LS].,,intellectual disability,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10595,"[""Charcot-Marie-Tooth disease""]",,"A neuromuscular disease that is characterized by a slowly progressive degeneration of the muscles of the foot, lower leg, hand and forearm.",false,,,http://purl.obolibrary.org/obo/DOID_440,,,,,,,,"A neuromuscular disease that is characterized by a slowly progressive degeneration of the muscles of the foot, lower leg, hand and forearm.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10595,,,,MESH:D002607|UMLS_CUI:C0007959|NCI:C75467|SNOMEDCT_US_2016_03_01:193162006|OMIM:PS118220|ICD10CM:G60.0|SNOMEDCT_US_2016_03_01:128202008|SNOMEDCT_US_2016_03_01:50548001|SNOMEDCT_US_2016_03_01:193158000|ICD9CM:356.1,Charcot Marie Tooth muscular atrophy|CMT - Charcot-Marie-Tooth disease|Peroneal muscular atrophy,,disease_ontology,,DOID:10595,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,Charcot-Marie-Tooth disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10591,"[""pre-eclampsia""]",,"A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy.",false,,,http://purl.obolibrary.org/obo/DOID_10763,,,,,,,,"A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10591,,,DOID:12684,SNOMEDCT_US_2016_03_01:46764007|MESH:D011225|NCI:C34943|OMIM:614592|SNOMEDCT_US_2016_03_01:156109003|SNOMEDCT_US_2016_03_01:198979002|SNOMEDCT_US_2016_03_01:15394000|OMIM:609402|ICD10CM:O14.90|OMIM:189800|SNOMEDCT_US_2016_03_01:156106005|SNOMEDCT_US_2016_03_01:398254007|NCI:C85021|ORDO:275555|UMLS_CUI:C0032914|SNOMEDCT_US_2016_03_01:288201007|ICD10CM:O14.9|SNOMEDCT_US_2016_03_01:237280005|SNOMEDCT_US_2016_03_01:198972006|ICD10CM:O14|SNOMEDCT_US_2016_03_01:199011002|SNOMEDCT_US_2016_03_01:267306006|SNOMEDCT_US_2016_03_01:6758009|OMIM:609404|OMIM:609403,preeclampsia/eclampsia|pregnancy associated hypertension|preeclampsia|proteinuric hypertension of pregnancy|pre-eclamptic toxaemia|gestational hypertension|toxaemia of pregnancy|pregnancy toxemia|hypertension induced by pregnancy,,disease_ontology,,DOID:10591,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,pre-eclampsia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004736,"[""B-CPAP cell""]",,Human papillary thyroid carcinoma derived cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003210,,,,,,,,Human papillary thyroid carcinoma derived cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004736,mgr,2010-09-29T08:47:36Z,,,,,BrendaTissueOBO,BCPAP cell,BTO:0004736,,,,,,,,,,,,,,,,,,,B-CPAP cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2034,"[""encephalomalacia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_936,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2034,,,,MESH:D004678|NCI:C98920|SNOMEDCT_US_2016_03_01:58762006|UMLS_CUI:C0014068,,,disease_ontology,,DOID:2034,,,,,,,,,,,,,,,,,,,encephalomalacia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200187,"[""GPR26 gene""]",,"A G-protein coupled receptor 26 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8NDV2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 26 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8NDV2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200187,,,,,,,,,,,,,,,,2849,GPR26,,,,,,,,,,,GPR26 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000319,"[""THR283 in ACVR1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000319,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR283 in ACVR1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/UBERON_0002097,"[""skin of body""]",skin|pelt|integument,"Nonparenchymatous organ that consists of the dermis and epidermis. Subdivisions of the skin surround various body parts; as a whole, the skin constitutes the external layer of the body.[FMA].",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000634|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,http://en.wikipedia.org/wiki/Skin|http://linkedlifedata.com/resource/umls/id/C1123023|http://www.snomedbrowser.com/Codes/Details/181469002|EHDAA2:0001844|FMA:7163|EMAPA:17525|ncithesaurus:Skin|UMLS:C1123023|OpenCyc:Mx4rvVjX3ZwpEbGdrcN5Y29ycA|MESH:A17.815|CALOHA:TS-0934|galen:Skin|XAO:0000023|EFO:0000962|BTO:0001253,"Nonparenchymatous organ that consists of the dermis and epidermis. Subdivisions of the skin surround various body parts; as a whole, the skin constitutes the external layer of the body.[FMA].",,http://upload.wikimedia.org/wikipedia/commons/thumb/6/6d/Skin.svg/200px-Skin.svg.png,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,entire skin,,uberon,skin|pelt|integument,,,,,,,,,,,,,,,,,,,,,,,,,,UBERON:0002097,,,Usage notes: consider 'integumentary system' for invertebrates. AO notes: Note that FMA uses 'skin' for the entire organ. XAO seems consistent. MA seems to use it analagously to zone of skin,,skin of body,,UBERON:0002097,,http://purl.obolibrary.org/obo/uberon.owl,http://purl.obolibrary.org/obo/uberon/core#efo_slim|http://purl.obolibrary.org/obo/uberon/core#major_organ|http://purl.obolibrary.org/obo/uberon/core#uberon_slim,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001457,"[""hip""]",,The laterally projecting region of each side of the lower or posterior part of the mammalian trunk formed by the lateral parts of the pelvis and upper part of the femur together with the fleshy parts covering them.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The laterally projecting region of each side of the lower or posterior part of the mammalian trunk formed by the lateral parts of the pelvis and upper part of the femur together with the fleshy parts covering them.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001457,,,,,,,BrendaTissueOBO,,BTO:0001457,,,,,,,,,,,,,,,,,,,hip,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200066,"[""CELSR3 gene""]",,"A cadherin EGF LAG seven-pass G-type receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYQ7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400032,,,,,,,,"A cadherin EGF LAG seven-pass G-type receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYQ7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200066,,,,,,,,,,,,,,,,1951,CELSR3,CDHF11|EGFL1|FMI1|KIAA0812|MEGF2,,,,,,,,,,CELSR3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100578,"[""Olfactory receptor 4D2""]",,"An olfactory receptor 4D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58180] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58180] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100578,,,,https://pharos.nih.gov/idg/targets/P58180,,,,,,,,,,,,,OR4D2,,,P58180,,,,,,,,Olfactory receptor 4D2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200259,"[""MRGPRF gene""]",,"A mas-related G-protein coupled receptor F that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96AM1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400063,,,,,,,,"A mas-related G-protein coupled receptor F that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96AM1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200259,,,,,,,,,,,,,,,,116535,MRGPRF,GPR140|GPR168|MRGF,,,,,,,,,,MRGPRF gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03390993,"[""TBC domain-containing protein kinase-like protein""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300232,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03390993,,,,,,,,,,,,,,,,,,,,,,,,,,,,TBC domain-containing protein kinase-like protein,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200036,"[""AGTR1 gene""]",,"An angiotensin II receptor 1A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30556] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400023,,,,,,,,"An angiotensin II receptor 1A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30556] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200036,,,,,,,,,,,,,,,,185,AGTR1,AGTR1A|AGTR1B|AT2R1|AT2R1B,,,,,,,,,,AGTR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400280,"[""RSK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400178,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400280,,,,,,,,,,,,,,,,,,,,,,,,,,,,RSK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1927,"[""sphingolipidosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_9455,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1927,,,,ICD10CM:E75.3|SNOMEDCT_US_2016_03_01:58459009|SNOMEDCT_US_2016_03_01:238028008|MESH:D013106|UMLS_CUI:C0037899|NCI:C117254,"sphingolipidoses|Sphingolipidosis (disorder)|Sphingolipidosis, NOS",,disease_ontology,,DOID:1927,,,,,,,,,,,,,,,,,,,sphingolipidosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000160,"[""MET323 in PAK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000160,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET323 in PAK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000388,"[""ROCK2 kinase domain""]",,"Rho-associated protein kinase 2; Rho-associated, coiled-coil containing protein kinase 2; KIAA0619; ROCK2",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Rho-associated protein kinase 2; Rho-associated, coiled-coil containing protein kinase 2; KIAA0619; ROCK2",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000388,,,,,,,,,,,,,,,,,,,200382,,,,,,,,,ROCK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117515,"[""Estrogen-related receptor gamma""]",,"An estrogen-related receptor gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62508] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117473,,,,,,,,"An estrogen-related receptor gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62508] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117515,,,,https://pharos.nih.gov/idg/targets/P62508,,,,,,,,,,,,,ESRRG,ERRG2,,P62508,,,,,,,,Estrogen-related receptor gamma,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200261,"[""GRIN1 gene""]",,"The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400459,,,,,,,,"The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200261,,,,,,,,,,,,,,,,2902,GRIN1,NMDAR1,,,,,,,,,,GRIN1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100075,"[""C-X-C chemokine receptor type 1""]",,"A C-X-C chemokine receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25024] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300031,,,,,,,,"A C-X-C chemokine receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25024] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100075,,,,https://pharos.nih.gov/idg/targets/P25024,,,,,,,,,,,,,CXCR1,CMKAR1|IL8RA,,P25024,,,,,,,,C-X-C chemokine receptor type 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9119,"[""acute myeloid leukemia""]",,A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.,false,,,http://purl.obolibrary.org/obo/DOID_8692,,,,,,,,A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9119,,,DOID:9118|DOID:9171,NCI:C3171|SNOMEDCT_US_2016_03_01:413443009|UMLS_CUI:C0023467|ICD10CM:C92.00|NCI:C27753|ICD9CM:205.0|OMIM:601626|SNOMEDCT_US_2016_03_01:91861009|SNOMEDCT_US_2016_03_01:154591002|SNOMEDCT_US_2016_03_01:17788007|ICD10CM:C92.0|MESH:D015470|KEGG:05221|SNOMEDCT_US_2016_03_01:277600006,"Leukemia, Myelocytic, acute|acute myeloblastic leukemia|acute myelogenous leukemia|AML - acute Myeloid Leukemia",,disease_ontology,,DOID:9119,http://purl.obolibrary.org/obo/doid#DO_cancer_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,acute myeloid leukemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200539,"[""OR2M2 gene""]",,"An olfactory receptor 2M2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R28] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2M2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R28] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200539,,,,,,,,,,,,,,,,391194,OR2M2,,,,,,,,,,,OR2M2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200376,"[""OR4A15 gene""]",,"An olfactory receptor 4A15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4A15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200376,,,,,,,,,,,,,,,,81328,OR4A15,,,,,,,,,,,OR4A15 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400340,"[""Intracellular chloride channel (icc) family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400340,,,,,,,,,,,,,,,,,,,,,,,,,,,,Intracellular chloride channel (icc) family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_18019,"[""L-lysine""]","L-2,6-Diaminocaproic acid|C6H14N2O2|lysine|6-ammonio-L-norleucine|146.18764|L-Lysin|146.106|(S)-alpha,epsilon-diaminocaproic acid|(S)-lysine|(S)-2,6-diaminohexanoic acid|lysinum|Lys|NCCCC[C@H](N)C(O)=O|InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/t5-/m0/s1|Lysine acid|lysina|K|0|KDXKERNSBIXSRK-YFKPBYRVSA-N",An L-alpha-amino acid; the L-isomer of lysine.,false,,,http://purl.obolibrary.org/obo/CHEBI_33709,,,,,,,PMID:22575419|HMDB:HMDB00182|CAS:56-87-1|Beilstein:1722531|PMID:23325920|PMID:23722415|PMID:25108762|ECMDB:ECMDB00182|Wikipedia:Lysine|Drug_Central:1622|Reaxys:1722531|Gmelin:364182|PMID:23167968|PMID:24831709|PMID:17051348|PMID:16901854|PMID:24064214|PMID:22735334|YMDB:YMDB00330|MetaCyc:LYS|PMID:10930630|DrugBank:DB00123|KNApSAcK:C00001378|KEGG:D02304|PMID:17979222|PMID:22019452|PMID:8587651|PMID:22064742|KEGG:C00047|PMID:8070089,An L-alpha-amino acid; the L-isomer of lysine.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:6264|CHEBI:43950|CHEBI:13135|CHEBI:21351,,"L-Lysine|(2S)-2,6-diaminohexanoic acid|L-lysine",,chebi_ontology,"L-2,6-Diaminocaproic acid|C6H14N2O2|lysine|6-ammonio-L-norleucine|146.18764|L-Lysin|146.106|(S)-alpha,epsilon-diaminocaproic acid|(S)-lysine|(S)-2,6-diaminohexanoic acid|lysinum|Lys|NCCCC[C@H](N)C(O)=O|InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/t5-/m0/s1|Lysine acid|lysina|K|0|KDXKERNSBIXSRK-YFKPBYRVSA-N",,,CHEBI:18019,,,,,,,,,,,,,,,,,,,,,,,CHEBI:18019,,,,,L-lysine,,CHEBI:18019,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300501,"[""Beta-4/CHRNB4 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300501,,,,,,,,,,,,,,,,,,,,,,,,,,,,Beta-4/CHRNB4 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004385,"[""cardinal vein""]",,Any of four longitudinal veins of the vertebrate embryo running anteriorly and posteriorly along each side of the spinal column with the pair on each side meeting at and discharging blood to the heart through the corresponding duct of Cuvier.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Any of four longitudinal veins of the vertebrate embryo running anteriorly and posteriorly along each side of the spinal column with the pair on each side meeting at and discharging blood to the heart through the corresponding duct of Cuvier.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004385,,,,,,,BrendaTissueOBO,Cuvierian vein|cardinal sinus,BTO:0004385,,,,,,,,,,,,,,,,,,,cardinal vein,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1799,"[""islet cell tumor""]",,A pancreatic cancer that is located_in the pancreatic islet cells.,false,,,http://purl.obolibrary.org/obo/DOID_1793|http://purl.obolibrary.org/obo/DOID_1428,,,,,,,,A pancreatic cancer that is located_in the pancreatic islet cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1799,,,DOID:10165,SNOMEDCT_US_2016_03_01:399528006|UMLS_CUI:C0242363|SNOMEDCT_US_2016_03_01:254611009|ICD10CM:D13.7|SNOMEDCT_US_2016_03_01:128878003|UMLS_CUI:C0496784|NCI:C27031|SNOMEDCT_US_2016_03_01:154609001|SNOMEDCT_US_2016_03_01:269636003|SNOMEDCT_US_2016_03_01:237596009|SNOMEDCT_US_2016_03_01:76345009|SNOMEDCT_US_2016_03_01:126864006|MESH:D007516|SNOMEDCT_US_2016_03_01:261713004|SNOMEDCT_US_2016_03_01:188855000|ICD10CM:C25.4,endocrine pancreas cancer|Islet cell tumor|pancreatic Endocrine neoplasm|malignant pancreatic Endocrine tumor|malignant tumor of endocrine pancreas (disorder)|Islet cell tumour|Islet cell neoplasm,,disease_ontology,,DOID:1799,,,,,,,,,,,,,,,,,,,islet cell tumor,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000400,"[""THR790 in EGFR(L747-T751del,Sins)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000400,,,,,,,,,,,,,,,,,,,,,,,,,,,,"THR790 in EGFR(L747-T751del,Sins)",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005117,"[""retinal ganglion cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005117,XPMUser,2011-05-05T11:09:05Z,,,,,BrendaTissueOBO,,BTO:0005117,,,,,,,,,,,,,,,,,,,retinal ganglion cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200062,"[""CDK16 gene""]",,"The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400256,,,,,,,,"The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200062,,,,,,,,,,,,,,,,5127,CDK16,PCTAIRE1|PCTK1,,,,,,,,,,CDK16 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000139,"[""H2 relaxin""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000139,,,,,,,,,,,,,,,,,,,,,,,,,,,,H2 relaxin,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400294,"[""P38 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400191,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400294,,,,,,,,,,,,,,,,,,,,,,,,,,,,P38 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000185,"[""MET516 in CDC2L1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000185,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET516 in CDC2L1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1770,"[""toxic megacolon""]",,,false,,,http://purl.obolibrary.org/obo/DOID_11372,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1770,,,,UMLS_CUI:C0025162|ICD10CM:K59.3|MESH:D008532|SNOMEDCT_US_2016_03_01:28536002,,,disease_ontology,,DOID:1770,,,,,,,,,,,,,,,,,,,toxic megacolon,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200029,"[""ASIC5 gene""]",,"This gene belongs to the amiloride-sensitive Na+ channel and degenerin (NaC/DEG) family, members of which have been identified in many animal species ranging from the nematode to human. The amiloride-sensitive Na(+) channel encoded by this gene is primarily expressed in the small intestine, however, its exact function is not known. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400380,,,,,,,,"This gene belongs to the amiloride-sensitive Na+ channel and degenerin (NaC/DEG) family, members of which have been identified in many animal species ranging from the nematode to human. The amiloride-sensitive Na(+) channel encoded by this gene is primarily expressed in the small intestine, however, its exact function is not known. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200029,,,,,,,,,,,,,,,,51802,ASIC5,ACCN5|HINAC,,,,,,,,,,ASIC5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001182,"[""primary root""]",,The main root of a plant is called the primary root; others are called secondary roots.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001188,,,,,,,,The main root of a plant is called the primary root; others are called secondary roots.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001182,,,,,,,BrendaTissueOBO,taproot|tap root,BTO:0001182,,,,,,,,,,,,,,,,,,,primary root,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300251,"[""ATR subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300129,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300251,,,,,,,,,,,,,,,,,,,,,,,,,,,,ATR subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000873,"[""MOLT-4 cell""]",,Human T cell leukemia established from the peripheral blood of a 19-year-old man with acute lymphoblastic leukemia (ALL) in relapse in 1971; sister cell line of MOLT-3.,false,,,http://purl.obolibrary.org/obo/BTO_0002504|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002144,,,,,,,,Human T cell leukemia established from the peripheral blood of a 19-year-old man with acute lymphoblastic leukemia (ALL) in relapse in 1971; sister cell line of MOLT-3.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000873,,,,,,,BrendaTissueOBO,MOLT4 cell,BTO:0000873,,,,,,,,,,,,,,,,,,,MOLT-4 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13088,"[""periventricular leukomalacia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2034,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13088,,,,NCI:C99013|ICD10CM:P91.2|ICD9CM:779.7|MESH:D007969|UMLS_CUI:C0023529|SNOMEDCT_US_2016_03_01:230769007,,,disease_ontology,,DOID:13088,,,,,,,,,,,,,,,,,,,periventricular leukomalacia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13087,"[""Lown-Ganong-Levine syndrome""]",,A syndrome that involves pre-excitation of the ventricles due to an accessory pathway providing an abnormal electrical communication from the atria to the ventricles.,false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,A syndrome that involves pre-excitation of the ventricles due to an accessory pathway providing an abnormal electrical communication from the atria to the ventricles.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13087,,,,ICD9CM:426.81|MESH:D008151|ICD10CM:I45.6|ORDO:844|SNOMEDCT_US_2016_03_01:55475008|UMLS_CUI:C0024054,"syndrome of short P-R interval, normal QRS complexes, and supraventricular tachycardias|atrial tachyarrhythmia with short PR interval",,disease_ontology,,DOID:13087,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,Lown-Ganong-Levine syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13089,"[""intracranial arterial disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_6713,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13089,,,,UMLS_CUI:C0752138|MESH:D020765,,,disease_ontology,,DOID:13089,,,,,,,,,,,,,,,,,,,intracranial arterial disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400385,"[""CACNA1E subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400333,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400385,,,,,,,,,,,,,,,,,,,,,,,,,,,,CACNA1E subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000211,"[""MET86 in NEK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000211,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET86 in NEK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300498,"[""Alpha-1/CHRNA1 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300498,,,,,,,,,,,,,,,,,,,,,,,,,,,,Alpha-1/CHRNA1 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050486,"[""exanthem""]",,,false,,,http://purl.obolibrary.org/obo/DOID_37,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050486,,,,UMLS_CUI:C0015230|SNOMEDCT_US_2016_03_01:112625008|SNOMEDCT_US_2016_03_01:158234002|ICD10CM:R21|SNOMEDCT_US_2016_03_01:271807003|SNOMEDCT_US_2016_03_01:206864004|SNOMEDCT_US_2016_03_01:206861007|SNOMEDCT_US_2016_03_01:158231005|SNOMEDCT_US_2016_03_01:206860008|SNOMEDCT_US_2016_03_01:139684003|NCI:C39594|SNOMEDCT_US_2016_03_01:267183006|ICD9CM:782.1|NCI:C111884|SNOMEDCT_US_2016_03_01:158230006|MESH:D005076|SNOMEDCT_US_2016_03_01:1806006,Rash|exanthema,,disease_ontology,,DOID:0050486,,,,,,,,,,,,,,,,,,,exanthem,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050481,"[""endemic typhus""]",,"A typhus that has_material_basis_in Rickettsia typhi or has_material_basis_in Rickettsia felis, which are transmitted_by fleas (Xenopsylla cheopis). The infection has_symptom headache, has_symptom fever, has_symptom chills, has_symptom myalgia, has_symptom nausea, has_symptom vomiting, has_symptom cough and has_symptom rash.",false,,,http://purl.obolibrary.org/obo/DOID_11256,,,,,,,,"A typhus that has_material_basis_in Rickettsia typhi or has_material_basis_in Rickettsia felis, which are transmitted_by fleas (Xenopsylla cheopis). The infection has_symptom headache, has_symptom fever, has_symptom chills, has_symptom myalgia, has_symptom nausea, has_symptom vomiting, has_symptom cough and has_symptom rash.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050481,,,DOID:0050028|DOID:0050058|DOID:0050030|DOID:0050057|DOID:0050029,,toulon typhus|cat flea rickettsiosis|Urban Typhus of Malaya|Rat-Flea Typhus|urban typhus|fleaborne typhus|murine typhus|Rickettsia felis spotted fever,,disease_ontology,Shop typhus,DOID:0050481,http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease|http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,endemic typhus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80345,"[""Cholecystokinin-33""]",CCK-33,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16133,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,CCK-33,,,CHEBI:80345,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80345,,,,,Cholecystokinin-33,,CHEBI:80345,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200580,"[""FGGY gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200580,,,,,,,,,,,,,,,,,,,,,,,,,,,,FGGY gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000318,"[""CV-1 cell""]",,"Normal kidney cell line. The CV-1 cell line was derived from the kidney of a male adult African green monkey by F.C. Jensen, et al in March, 1964 for use in Rous sarcoma virus transformation studies.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000067|http://purl.obolibrary.org/obo/BTO_0000453,,,,,,,,"Normal kidney cell line. The CV-1 cell line was derived from the kidney of a male adult African green monkey by F.C. Jensen, et al in March, 1964 for use in Rous sarcoma virus transformation studies.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000318,,,,,,,BrendaTissueOBO,CV1 cell|CV 1 cell,BTO:0000318,,,,,,,,,,,,,,,,,,,CV-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100298,"[""Sodium channel protein type 7 subunit alpha""]",,"A sodium channel protein type 7 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q01118] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300472,,,,,,,,"A sodium channel protein type 7 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q01118] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100298,,,,https://pharos.nih.gov/idg/targets/Q01118,,,,,,,,,,,,,SCN7A,SCN6A,,Q01118,,,,,,,,Sodium channel protein type 7 subunit alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002252,"[""subthalamic nucleus""]",,A biconvex mass of gray matter on the medial side of the junction of the internal capsule and the crus cerebri; its chief connections are with the globus pallidus.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A biconvex mass of gray matter on the medial side of the junction of the internal capsule and the crus cerebri; its chief connections are with the globus pallidus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002252,,,,,,,BrendaTissueOBO,nucleus of Luys|Luys' body|nucleus subthalamicus,BTO:0002252,,,,,,,,,,,,,,,,,,,subthalamic nucleus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000172,"[""FLT4 kinase domain""]",,Fms-related tyrosine kinase 4; FLT4; FLT41; LMPH1A; PCL; VEGFR3,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Fms-related tyrosine kinase 4; FLT4; FLT41; LMPH1A; PCL; VEGFR3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000172,,,,,,,,,,,,,,,,,,,200175,,,,,,,,,FLT4 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200714,"[""OR9G1 gene""]",,"An olfactory receptor 9G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH87] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 9G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH87] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200714,,,,,,,,,,,,,,,,390174,OR9G1,OR9G5,,,,,,,,,,OR9G1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000269,"[""PHE691 in FLT3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000269,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE691 in FLT3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4079,"[""heart valve disease""]",,A heart disease involving one or more of the four valves of the heart (the aortic and mitral valves on the left and the pulmonary and tricuspid valves on the right).,false,,,http://purl.obolibrary.org/obo/DOID_114,,,,,,,,A heart disease involving one or more of the four valves of the heart (the aortic and mitral valves on the left and the pulmonary and tricuspid valves on the right).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4079,,,DOID:989,NCI:C45525|SNOMEDCT_US_2016_03_01:195013005|SNOMEDCT_US_2016_03_01:398995000|MESH:D016127|UMLS_CUI:C0018824|MESH:D006349|UMLS_CUI:C0079485|SNOMEDCT_US_2016_03_01:368009,Valvular heart disease,,disease_ontology,,DOID:4079,,,,,,,,,,,,,,,,,,,heart valve disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100702,"[""Olfactory receptor 8j2""]",,"An olfactory receptor 8J2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 8J2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100702,,,,https://pharos.nih.gov/idg/targets/Q8NGG1,,,,,,,,,,,,,OR8J2,OR8J2P,,Q8NGG1,,,,,,,,Olfactory receptor 8j2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200121,"[""GIPR gene""]",,"A gastric inhibitory polypeptide receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48546] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400047,,,,,,,,"A gastric inhibitory polypeptide receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48546] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200121,,,,,,,,,,,,,,,,2696,GIPR,,,,,,,,,,,GIPR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100287,"[""Sulfate anion transporter 1""]",,"A sulfate anion transporter 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H2B4] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300368,,,,,,,,"A sulfate anion transporter 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H2B4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100287,,,,https://pharos.nih.gov/idg/targets/Q9H2B4,,,,,,,,,,,,,SLC26A1,SAT1,,Q9H2B4,,,,,,,,Sulfate anion transporter 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300561,"[""Kv7.1/KCNQ1 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300449,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300561,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv7.1/KCNQ1 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000222,"[""MET92 in RIPK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000222,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET92 in RIPK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8725,"[""vascular dementia""]",,A dementia that involves impairments in cognitive function caused by problems in blood vessels that feed the brain.,false,,,http://purl.obolibrary.org/obo/DOID_1307,,,,,,,,A dementia that involves impairments in cognitive function caused by problems in blood vessels that feed the brain.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8725,,,DOID:13915,UMLS_CUI:C0011263|SNOMEDCT_US_2016_03_01:192167008|NCI:C34522|SNOMEDCT_US_2016_03_01:192165000|SNOMEDCT_US_2016_03_01:192171006|ICD9CM:290.4|MESH:D015140|SNOMEDCT_US_2016_03_01:56267009|SNOMEDCT_US_2016_03_01:268613002|SNOMEDCT_US_2016_03_01:154850006|NCI:C34525|ICD10CM:F01.5|SNOMEDCT_US_2016_03_01:191462009|SNOMEDCT_US_2016_03_01:429998004|UMLS_CUI:C0011269|MESH:D015161|ICD10CM:F01,multifocal dementia|Multi Infarct Dementia,,disease_ontology,,DOID:8725,,,,,,,,,,,,,,,,,,,vascular dementia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000076,"[""CDK3 kinase domain""]",,Cyclin-dependent kinase 3; CDK3,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Cyclin-dependent kinase 3; CDK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000076,,,,,,,,,,,,,,,,,,,200076,,,,,,,,,CDK3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000375,"[""RAF1 kinase domain""]",,RAF proto-oncogene serine/threonine-protein kinase; CRAF; c-Raf; NS5; RAF1; Raf-1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,RAF proto-oncogene serine/threonine-protein kinase; CRAF; c-Raf; NS5; RAF1; Raf-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000375,,,,,,,,,,,,,,,,,,,200369,,,,,,,,,RAF1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200310,"[""OR10H4 gene""]",,"An olfactory receptor 10H4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10H4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200310,,,,,,,,,,,,,,,,126541,OR10H4,,,,,,,,,,,OR10H4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002967,"[""SK-MEL-37 cell""]",,Human cell line established from a metastatic melanoma.,false,,,http://purl.obolibrary.org/obo/BTO_0002130|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human cell line established from a metastatic melanoma.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002967,,,,,,,BrendaTissueOBO,SK-MEL37 cell,BTO:0002967,,,,,,,,,,,,,,,,,,,SK-MEL-37 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000099,"[""astrocyte""]",,"A star-shaped cell, especially a neuroglial cell of nervous tissue.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000771,,,,,,,,"A star-shaped cell, especially a neuroglial cell of nervous tissue.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000099,,,,,,,BrendaTissueOBO,,BTO:0000099,,,,,,,,,,,,,,,,,,,astrocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2908,"[""Treacher Collins syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2908,,,,SNOMEDCT_US_2016_03_01:205804007|NCI:C75018|OMIM:613717|OMIM:248390|SNOMEDCT_US_2016_03_01:205416009|MESH:D008342|SNOMEDCT_US_2016_03_01:82203000|OMIM:154500|UMLS_CUI:C0242387|ICD10CM:Q75.4,(Mandibulofacial dysostosis) or (Franceschetti syndrome)|mandibulofacial dysostosis,,disease_ontology,,DOID:2908,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Treacher Collins syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002267,"[""rhabdomyosarcoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000400,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002267,,,,,,,BrendaTissueOBO,,BTO:0002267,,,,,,,,,,,,,,,,,,,rhabdomyosarcoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000390,"[""RPS6KA4(Kin.Dom.1-N-terminal) kinase domain""]",,"Ribosomal protein S6 kinase, 90kDa, polypeptide 4; MSK2; RPS6KA4; RSK-B",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Ribosomal protein S6 kinase, 90kDa, polypeptide 4; MSK2; RPS6KA4; RSK-B",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000390,,,,,,,,,,,,,,,,,,,"200389, 200390",,,,,,,,,RPS6KA4(Kin.Dom.1-N-terminal) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_7542,"[""neurotensin""]","PCJGZPGTCUMMOT-UHFFFAOYSA-N|
InChI=1S/C78H121N21O20/c1-7-43(6)63(73(115)96-57(76(118)119)37-42(4)5)97-70(112)55(39-45-21-25-47(101)26-22-45)95-72(114)59-18-13-35-99(59)75(117)52(16-11-33-86-78(83)84)90-64(106)48(15-10-32-85-77(81)82)89-71(113)58-17-12-34-98(58)74(116)51(14-8-9-31-79)91-69(111)56(40-60(80)102)94-66(108)50(28-30-62(104)105)88-68(110)54(38-44-19-23-46(100)24-20-44)93-67(109)53(36-41(2)3)92-65(107)49-27-29-61(103)87-49/h19-26,41-43,48-59,63,100-101H,7-18,27-40,79H2,1-6H3,(H2,80,102)(H,87,103)(H,88,110)(H,89,113)(H,90,106)(H,91,111)(H,92,107)(H,93,109)(H,94,108)(H,95,114)(H,96,115)(H,97,112)(H,104,105)(H,118,119)(H4,81,82,85)(H4,83,84,86)
|
CCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C1CCCN1C(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)C(CC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CC(C)C)NC(=O)C1CCC(=O)N1)C(=O)NC(CC(C)C)C(O)=O
|C78H121N21O20",A polypeptide that has formula C78H121N21O20.,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,ChemIDplus:39379-15-2|KEGG COMPOUND:55508-42-4|KEGG COMPOUND:C01836|KEGG COMPOUND:39379-15-2,A polypeptide that has formula C78H121N21O20.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,"
5-oxo-L-prolyl-L-leucyl-L-tyrosyl-L-alpha-glutamyl-L-asparaginyl-L-lysyl-L-prolyl-L-arginyl-L-arginyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine
|Neurotensin|
Glp-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH
",,chebi_ontology,"PCJGZPGTCUMMOT-UHFFFAOYSA-N|
InChI=1S/C78H121N21O20/c1-7-43(6)63(73(115)96-57(76(118)119)37-42(4)5)97-70(112)55(39-45-21-25-47(101)26-22-45)95-72(114)59-18-13-35-99(59)75(117)52(16-11-33-86-78(83)84)90-64(106)48(15-10-32-85-77(81)82)89-71(113)58-17-12-34-98(58)74(116)51(14-8-9-31-79)91-69(111)56(40-60(80)102)94-66(108)50(28-30-62(104)105)88-68(110)54(38-44-19-23-46(100)24-20-44)93-67(109)53(36-41(2)3)92-65(107)49-27-29-61(103)87-49/h19-26,41-43,48-59,63,100-101H,7-18,27-40,79H2,1-6H3,(H2,80,102)(H,87,103)(H,88,110)(H,89,113)(H,90,106)(H,91,111)(H,92,107)(H,93,109)(H,94,108)(H,95,114)(H,96,115)(H,97,112)(H,104,105)(H,118,119)(H4,81,82,85)(H4,83,84,86)
|
CCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C1CCCN1C(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)C(CC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CC(C)C)NC(=O)C1CCC(=O)N1)C(=O)NC(CC(C)C)C(O)=O
|C78H121N21O20",,,CHEBI:7542,,,,,,,,,,,,,,,,,,,,,,,CHEBI:7542,,,,,Neurotensin|neurotensin,,CHEBI:7542,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000368,"[""PLK2 kinase domain""]",,Serine/threonine-protein kinase PLK2; polo-like kinase 2 (Drosophila); PLK2; SNK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase PLK2; polo-like kinase 2 (Drosophila); PLK2; SNK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000368,,,,,,,,,,,,,,,,,,,200351,,,,,,,,,PLK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100074,"[""Cyclin-dependent kinase 8""]",,"cyclin-dependent kinase 8 (CDK8)  with  no mutation  in a nonphosphorylated state|A cyclin-dependent kinase 8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49336] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300257,,,,,,,,"cyclin-dependent kinase 8 (CDK8)  with  no mutation  in a nonphosphorylated state|A cyclin-dependent kinase 8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49336] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100074,,,,https://pharos.nih.gov/idg/targets/P49336,,,,,,,,,,,,,CDK8,,,P49336,,,,,,,,Cyclin-dependent kinase 8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3498,"[""pancreatic ductal adenocarcinoma""]",,A pancreatic adenocarcinoma that derives_from pancreatic duct cells.,false,,,http://purl.obolibrary.org/obo/DOID_4074,,,,,,,,A pancreatic adenocarcinoma that derives_from pancreatic duct cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3498,,,,UMLS_CUI:C1335302|NCI:C9120,ductal adenocarcinoma of the pancreas,,disease_ontology,,DOID:3498,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,pancreatic ductal adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002820,"[""oligodendroglioma cell line""]",,"A rare slow-growing type of brain tumor that begins in cells called oligodendrocytes, which provide support and nourishment for cells that transmit nerve impulses.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A rare slow-growing type of brain tumor that begins in cells called oligodendrocytes, which provide support and nourishment for cells that transmit nerve impulses.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002820,,,,,,,BrendaTissueOBO,oligodendroglial tumor cell line,BTO:0002820,,,,,,,,,,,,,,,,,,,oligodendroglioma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000122,"[""MET138 in MAPKAPK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000122,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET138 in MAPKAPK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200139,"[""ADGRA3 gene""]",,"A G-protein coupled receptor 125 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IWK6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,"A G-protein coupled receptor 125 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IWK6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200139,,,,,,,,,,,,,,,,166647,GPR125,,,,,,,,,,,ADGRA3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000373,"[""Ehrlich ascites carcinoma cell""]",,Mouse cancer cell.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000150,,,,,,,,Mouse cancer cell.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000373,,,,,,,BrendaTissueOBO,Ehrlich ascites tumor cell|EAT cell,BTO:0000373,,,,,,,,,,,,,,,,,,,Ehrlich ascites carcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491017,"[""Hexokinase family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400325,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491017,,,,,,,,,,,,,,,,,,,,,,,,,,,,Hexokinase family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100140,"[""Receptor tyrosine-protein kinase erbb-3""]",,"receptor tyrosine-protein kinase erbb-3 (ERBB3)  with  no mutation  in a nonphosphorylated state|A receptor tyrosine-protein kinase erbB-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P21860] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300152,,,,,,,,"receptor tyrosine-protein kinase erbb-3 (ERBB3)  with  no mutation  in a nonphosphorylated state|A receptor tyrosine-protein kinase erbB-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P21860] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100140,,,,https://pharos.nih.gov/idg/targets/P21860,,,,,,,,,,,,,ERBB3,HER3,,P21860,,,,,,,,Receptor tyrosine-protein kinase erbb-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6193,"[""epithelioid sarcoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3350,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6193,,,,SNOMEDCT_US_2016_03_01:59238007|NCI:C3714|UMLS_CUI:C0205944|MESH:D012509,epithelioid sarcoma (morphologic abnormality)|epithelioid cell sarcoma,,disease_ontology,,DOID:6193,,,,,,,,,,,,,,,,,,,epithelioid sarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200136,"[""GPR119 gene""]",,"A glucose-dependent insulinotropic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDV5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A glucose-dependent insulinotropic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDV5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200136,,,,,,,,,,,,,,,,139760,GPR119,,,,,,,,,,,GPR119 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000028,"[""ACVR1 kinase domain""]",,"Activin A receptor, type I; ACTRI; ACVR1; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Activin A receptor, type I; ACTRI; ACVR1; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000028,,,,,,,,,,,,,,,,,,,200027,,,,,,,,,ACVR1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100710,"[""Olfactory receptor 8U9""]",,"An olfactory receptor 8U9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7N5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 8U9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7N5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100710,,,,https://pharos.nih.gov/idg/targets/P0C7N5,,,,,,,,,,,,,OR8U9,,,P0C7N5,,,,,,,,Olfactory receptor 8U9,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003212,"[""T-lymphoma cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0000104|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003212,,,,,,,BrendaTissueOBO,T-cell lymphoma cell line,BTO:0003212,,,,,,,,,,,,,,,,,,,T-lymphoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200327,"[""TRPM2 gene""]",,"The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400584,,,,,,,,"The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200327,,,,,,,,,,,,,,,,7226,TRPM2,EREG1|KNP3|LTRPC2|TRPC7,,,,,,,,,,TRPM2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491021,"[""FGGY kinase family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400324,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491021,,,,,,,,,,,,,,,,,,,,,,,,,,,,FGGY kinase family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200311,"[""TMC3 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400372,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200311,,,,,,,,,,,,,,,,342125,TMC3,,,,,,,,,,,TMC3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200233,"[""HRH4 gene""]",,"An H4 histamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H3N8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400061,,,,,,,,"An H4 histamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H3N8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200233,,,,,,,,,,,,,,,,59340,HRH4,GPCR105,,,,,,,,,,HRH4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200072,"[""CRHR1 gene""]",,"A corticotropin-releasing factor receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P34998] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400036,,,,,,,,"A corticotropin-releasing factor receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P34998] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200072,,,,,,,,,,,,,,,,1394,CRHR1,CRFR|CRFR1|CRHR,,,,,,,,,,CRHR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000093,"[""CLK4 kinase domain""]",,CDC-like kinase 4; CLK4; DKFZp686A20267,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,CDC-like kinase 4; CLK4; DKFZp686A20267,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000093,,,,,,,,,,,,,,,,,,,200093,,,,,,,,,CLK4 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100451,"[""Olfactory receptor 5AP2""]",,"An olfactory receptor 5AP2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5AP2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100451,,,,https://pharos.nih.gov/idg/targets/Q8NGF4,,,,,,,,,,,,,OR5AP2,,,Q8NGF4,,,,,,,,Olfactory receptor 5AP2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200571,"[""YES1 gene""]",,"This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400132,,,,,,,,"This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200571,,,,,,,,,,,,,,,,7525,YES1,YES,,,,,,,,,,YES1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200442,"[""OR56B1 gene""]",,"An olfactory receptor 56B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 56B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200442,,,,,,,,,,,,,,,,387748,OR56B1,OR56B1P,,,,,,,,,,OR56B1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000349,"[""THR342 in FYN""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000349,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR342 in FYN,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000440,"[""TNK2 kinase domain""]",,"Tyrosine kinase, non-receptor, 2; ACK; ACK1; FLJ44758; FLJ45547; p21cdc42Hs; TNK2",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Tyrosine kinase, non-receptor, 2; ACK; ACK1; FLJ44758; FLJ45547; p21cdc42Hs; TNK2",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000440,,,,,,,,,,,,,,,,,,,200441,,,,,,,,,TNK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400591,"[""TRPV2 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400484,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400591,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPV2 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000248,"[""M4K1 kinase domain""]",,Mitogen-activated protein kinase kinase kinase kinase 1; HPK1; MAP4K1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase kinase kinase kinase 1; HPK1; MAP4K1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000248,,,,,,,,,,,,,,,,,,,200190,,,,,,,,,M4K1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100688,"[""Olfactory receptor 8b4""]",,"An olfactory receptor 8B4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RC9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 8B4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RC9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100688,,,,https://pharos.nih.gov/idg/targets/Q96RC9,,,,,,,,,,,,,OR8B4,OR8B4P,,Q96RC9,,,,,,,,Olfactory receptor 8b4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300104,"[""Other group""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300102,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,Other group,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400016,"[""Vomeronasal receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400016,,,,,,,,,,,,,,,,,,,,,,,,,,,,Vomeronasal receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100509,"[""Ste20-related kinase adapter protein alpha""]",,"A STE20-related kinase adapter protein alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7RTN6] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300187,,,,,,,,"A STE20-related kinase adapter protein alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7RTN6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100509,,,,https://pharos.nih.gov/idg/targets/Q7RTN6,,,,,,,,,,,,,STRADA,LYK5|STRAD,,Q7RTN6,,,,,,,,Ste20-related kinase adapter protein alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000256,"[""PHE267 in CAMKK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000256,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE267 in CAMKK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10969,"[""hemiplegia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_331,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10969,,,,SNOMEDCT_US_2016_03_01:155024003|MESH:D006429|SNOMEDCT_US_2016_03_01:155026001|ICD9CM:343.4|UMLS_CUI:C0392550|SNOMEDCT_US_2016_03_01:192955007|SNOMEDCT_US_2016_03_01:267696006|SNOMEDCT_US_2016_03_01:192952005|SNOMEDCT_US_2016_03_01:1593000|SNOMEDCT_US_2016_03_01:155025002,Postnatal infantile hemiplegia|Infantile hemiplegia,,disease_ontology,,DOID:10969,,,,,,,,,,,,,,,,,,,hemiplegia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100148,"[""G-protein coupled receptor 143""]",,"A G-protein coupled receptor 143 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51810] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300006,,,,,,,,"A G-protein coupled receptor 143 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51810] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100148,,,,https://pharos.nih.gov/idg/targets/P51810,,,,,,,,,,,,,GPR143,OA1,,P51810,,,,,,,,G-protein coupled receptor 143,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300549,"[""Kv6.1/KCNG1 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300447,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300549,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv6.1/KCNG1 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100321,"[""Mitogen-activated protein kinase 9""]",,"A mitogen-activated protein kinase 9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P45984] |mitogen-activated protein kinase 9 (MK09)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300293,,,,,,,,"A mitogen-activated protein kinase 9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P45984] |mitogen-activated protein kinase 9 (MK09)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100321,,,,https://pharos.nih.gov/idg/targets/P45984,,,,,,,,,,,,,MAPK9,JNK2|PRKM9|SAPK1A,,P45984,,,,,,,,Mitogen-activated protein kinase 9,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100216,"[""Potassium channel subfamily K member 4""]",,"A potassium channel subfamily K member 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYG8] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300359,,,,,,,,"A potassium channel subfamily K member 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYG8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100216,,,,https://pharos.nih.gov/idg/targets/Q9NYG8,,,,,,,,,,,,,KCNK4,TRAAK,,Q9NYG8,,,,,,,,Potassium channel subfamily K member 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200298,"[""OR10D3 gene""]",,"An olfactory receptor 958 that is encoded in the genome of human. [OMA:HUMAN05487, PRO:DNx] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 958 that is encoded in the genome of human. [OMA:HUMAN05487, PRO:DNx] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200298,,,,,,,,,,,,,,,,26497,OR10D3,OR10D3P,,,,,,,,,,OR10D3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100542,"[""Olfactory receptor 2M5""]",,"An olfactory receptor 2M5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A3KFT3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2M5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A3KFT3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100542,,,,https://pharos.nih.gov/idg/targets/A3KFT3,,,,,,,,,,,,,OR2M5,OR2M5P,,A3KFT3,,,,,,,,Olfactory receptor 2M5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400145,"[""DMPK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400145,,,,,,,,,,,,,,,,,,,,,,,,,,,,DMPK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200471,"[""SGK1 gene""]",,"This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400224,,,,,,,,"This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200471,,,,,,,,,,,,,,,,6446,SGK1,SGK,,,,,,,,,,SGK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4906,"[""small intestine adenocarcinoma""]",,A small intestine carcinoma that derives_from epithelial cells of glandular origin.,false,,,http://purl.obolibrary.org/obo/DOID_4907|http://purl.obolibrary.org/obo/DOID_299,,,,,,,,A small intestine carcinoma that derives_from epithelial cells of glandular origin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4906,,,,SNOMEDCT_US_2016_03_01:424440001|UMLS_CUI:C0278803|NCI:C7888,small intestinal adenocarcinoma,,disease_ontology,adenocarcinoma of small Intestine,DOID:4906,,,,,,,,,,,,,,,,,,,small intestine adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001664,"[""hepatoblastoma cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0000578|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001664,,,,,,,BrendaTissueOBO,,BTO:0001664,,,,,,,,,,,,,,,,,,,hepatoblastoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200225,"[""PRKG2 gene""]",,"This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400173,,,,,,,,"This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200225,,,,,,,,,,,,,,,,5593,PRKG2,PRKGR2,,,,,,,,,,PRKG2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002923,"[""BEAS-2B cell""]",,Epithelial cells were isolated from normal human bronchial epithelium obtained from autopsy of non-cancerous individuals.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002022,,,,,,,,Epithelial cells were isolated from normal human bronchial epithelium obtained from autopsy of non-cancerous individuals.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002923,,,,,,,BrendaTissueOBO,BEAS2B cell|BEAS 2B cell|B2B cell,BTO:0002923,,,,,,,,,,,,,,,,,,,BEAS-2B cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300558,"[""Kv11.2/KCNH6 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300448,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300558,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv11.2/KCNH6 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000234,"[""LCK kinase domain""]",,Lymphocyte-specific protein tyrosine kinase; LCK; LSK; p56lck; pp58lck; YT16,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Lymphocyte-specific protein tyrosine kinase; LCK; LSK; p56lck; pp58lck; YT16,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000234,,,,,,,,,,,,,,,,,,,200224,,,,,,,,,LCK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3230,"[""high pressure neurological syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_331,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3230,,,,UMLS_CUI:C0019537|MESH:D006610,,,disease_ontology,,DOID:3230,,,,,,,,,,,,,,,,,,,high pressure neurological syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004232,"[""tsA-201 cell""]",,A transformed human kidney 293 cell line stably expressing an SV40 temperature-sensitive T antigen.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A transformed human kidney 293 cell line stably expressing an SV40 temperature-sensitive T antigen.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004232,,,,,,,BrendaTissueOBO,tsA201 cell,BTO:0004232,,,,,,,,,,,,,,,,,,,tsA-201 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000017,"[""A-431 cell""]",,Human epidermoid carcinoma established from the solid tumor of an 85-year-old woman; cells were reported to have large numbers of EGF binding sites; cell line was used as indicator cell line for anti-TGF binding.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000297,,,,,,,,Human epidermoid carcinoma established from the solid tumor of an 85-year-old woman; cells were reported to have large numbers of EGF binding sites; cell line was used as indicator cell line for anti-TGF binding.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000017,,,,,,,BrendaTissueOBO,A431 cell,BTO:0000017,,,,,,,,,,,,,,,,,,,A-431 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001948,"[""JURKAT E-6.1 cell""]",,"Human, blood, leukemia, T cell line, clone E6.1.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Human, blood, leukemia, T cell line, clone E6.1.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001948,,,,,,,BrendaTissueOBO,JURKAT E-61 cell,BTO:0001948,,,,,,,,,,,,,,,,,,,JURKAT E-6.1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4907,"[""small intestine carcinoma""]",,A small intestine cancer that develops from epithelial cells and is located_in the small intestine.,false,,,http://purl.obolibrary.org/obo/DOID_305|http://purl.obolibrary.org/obo/DOID_10154,,,,,,,,A small intestine cancer that develops from epithelial cells and is located_in the small intestine.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4907,,,,NCI:C7724|UMLS_CUI:C0238196,small intestinal carcinoma,,disease_ontology,cancer of the small bowel|small bowel cancer,DOID:4907,,,,,,,,,,,,,,,,,,,small intestine carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100218,"[""Metabotropic glutamate receptor 1""]",,"A metabotropic glutamate receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13255] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300059,,,,,,,,"A metabotropic glutamate receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13255] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100218,,,,https://pharos.nih.gov/idg/targets/Q13255,,,,,,,,,,,,,GRM1,GPRC1A|MGLUR1,,Q13255,,,,,,,,Metabotropic glutamate receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3877,"[""functional colonic disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3877,,,,MESH:D003109|UMLS_CUI:C0009374,,,disease_ontology,,DOID:3877,,,,,,,,,,,,,,,,,,,functional colonic disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200201,"[""GPR55 gene""]",,"A G-protein coupled receptor 55 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y2T6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 55 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y2T6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200201,,,,,,,,,,,,,,,,9290,GPR55,,,,,,,,,,,GPR55 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3298,"[""vaccinia""]",,"A viral infectious disease that results_in infection, located_in skin, has_material_basis_in Vaccinia virus, which is used as a live vaccine against smallpox. The virus is transmitted_by contact with the vaccination site before it has healed, or transmitted_by fomites that have been contaminated with live virus from the vaccination site. The infection has_symptom rash, has_symptom fever, and has_symptom body aches.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in infection, located_in skin, has_material_basis_in Vaccinia virus, which is used as a live vaccine against smallpox. The virus is transmitted_by contact with the vaccination site before it has healed, or transmitted_by fomites that have been contaminated with live virus from the vaccination site. The infection has_symptom rash, has_symptom fever, and has_symptom body aches.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3298,,,,MESH:D014615|UMLS_CUI:C0042214|SNOMEDCT_US_2016_03_01:111852003,,,disease_ontology,,DOID:3298,,,,,,,,,,,,,,,,,,,vaccinia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_7455,"[""hypogonadotropism""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2277,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:7455,,,,,,,disease_ontology,,DOID:7455,,,,,,,,,,,,,,,,,,,hypogonadotropism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100176,"[""G-protein coupled estrogen receptor 1""]",,"A G-protein coupled estrogen receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99527] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300056,,,,,,,,"A G-protein coupled estrogen receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99527] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100176,,,,https://pharos.nih.gov/idg/targets/Q99527,,,,,,,,,,,,,GPER1,CEPR|CMKRL2|DRY12|GPER|GPR30,,Q99527,,,,,,,,G-protein coupled estrogen receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200357,"[""NEK3 gene""]",,"This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400197,,,,,,,,"This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200357,,,,,,,,,,,,,,,,4752,NEK3,,,,,,,,,,,NEK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2952,"[""inner ear disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2742,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2952,,,,SNOMEDCT_US_2016_03_01:286945007|UMLS_CUI:C0022890|MESH:D007759|SNOMEDCT_US_2016_03_01:267763004|SNOMEDCT_US_2016_03_01:20425006|SNOMEDCT_US_2016_03_01:267761002|ICD10CM:H80-H83|SNOMEDCT_US_2016_03_01:194690003|ICD10CM:H83.9|NCI:C27166|UMLS_CUI:C0494559|ICD10CM:H83.90|SNOMEDCT_US_2016_03_01:232297009,labyrinthine disease,,disease_ontology,,DOID:2952,,,,,,,,,,,,,,,,,,,inner ear disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000287,"[""corneal epithelium""]",,Posterior epithelium of cornea: the mesothelial layer covering the posterior surface of the posterior limiting lamina of the cornea; it was once believed to extend to the anterior surface of the stroma of the iris.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Posterior epithelium of cornea: the mesothelial layer covering the posterior surface of the posterior limiting lamina of the cornea; it was once believed to extend to the anterior surface of the stroma of the iris.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000287,,,,,,,BrendaTissueOBO,anterior endothelium of cornea|corneal endothelium|endothelium camerae anterioris bulbi|epithelium posterius corneae|endothelium corneale|endothelium anterius corneae,BTO:0000287,,,,,,,,,,,,,,,,,,,corneal epithelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200252,"[""RPS6KA2 gene""]",,"This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400280,,,,,,,,"This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200252,,,,,,,,,,,,,,,,6196,RPS6KA2,MAPKAPK1C|RSK3,,,,,,,,,,RPS6KA2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5408,"[""Paget's disease of bone""]",,"A bone formation disease that has_material_basis_in hyperactive osteoclast which results_in abnormal osteoblast bone formation located_in skull, located_in pelvis, located_in vertebral column, located_in set of limbs.",false,,,http://purl.obolibrary.org/obo/DOID_205,,,,,,,,"A bone formation disease that has_material_basis_in hyperactive osteoclast which results_in abnormal osteoblast bone formation located_in skull, located_in pelvis, located_in vertebral column, located_in set of limbs.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5408,,,,SNOMEDCT_US_2016_03_01:156811005|SNOMEDCT_US_2016_03_01:2089002|SNOMEDCT_US_2016_03_01:156812003|ICD10CM:M88|SNOMEDCT_US_2016_03_01:203353000|OMIM:167250|SNOMEDCT_US_2016_03_01:203354006|MESH:D010001|OMIM:606263|NCI:C3292|EFO:0004261|ORDO:280110|OMIM:602080|UMLS_CUI:C0029401,Paget disease of bone|Paget's bone disease|osseous Paget's disease|osteitis deformans,,disease_ontology,Familial Paget's disease of bone,DOID:5408,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
MESH:C538098 added from NeuroDevNet [WAK].",,Paget's disease of bone,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002120,"[""pyloric cecum""]",,The pyloric ceca (or digestive glands) and the cardiac stomach produce digestive enzymes in starfishes. Digested material is absorbed through the pyloric ceca for transport to the rest of the body. Each pyloric cecum extends the length of each arm.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001806,,,,,,,,The pyloric ceca (or digestive glands) and the cardiac stomach produce digestive enzymes in starfishes. Digested material is absorbed through the pyloric ceca for transport to the rest of the body. Each pyloric cecum extends the length of each arm.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002120,,,,,,,BrendaTissueOBO,pyloric caecum,BTO:0002120,,,,,,,,,,,,,,,,,,,pyloric cecum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001274,"[""spermatid""]",,One of the haploid cells that are formed by division of the secondary spermatocytes and that differentiate into spermatozoa.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,One of the haploid cells that are formed by division of the secondary spermatocytes and that differentiate into spermatozoa.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001274,,,,,,,BrendaTissueOBO,spermatoblast,BTO:0001274,,,,,,,,,,,,,,,,,,,spermatid,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100534,"[""Thiamin pyrophosphokinase 1""]",,"A thiamin pyrophosphokinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H3S4] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391023,,,,,,,,"A thiamin pyrophosphokinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H3S4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100534,,,,https://pharos.nih.gov/idg/targets/Q9H3S4,,,,,,,,,,,,,TPK1,,,Q9H3S4,,,,,,,,Thiamin pyrophosphokinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100048,"[""Calcitonin receptor""]",,"A calcitonin receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30988] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300028,,,,,,,,"A calcitonin receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30988] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100048,,,,https://pharos.nih.gov/idg/targets/P30988,,,,,,,,,,,,,CALCR,,,P30988,,,,,,,,Calcitonin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400381,"[""CACNA1A subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400333,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400381,,,,,,,,,,,,,,,,,,,,,,,,,,,,CACNA1A subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200523,"[""OR2F2 gene""]",,"An olfactory receptor 2F2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95006] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2F2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95006] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200523,,,,,,,,,,,,,,,,135948,OR2F2,,,,,,,,,,,OR2F2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01390004,"[""ligand-gated ion channel""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01390004,,,,,,,,,,,,,,,,,,,,,,,,,,,,ligand-gated ion channel,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300355,"[""Potassium channel family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300355,,,,,,,,,,,,,,,,,,,,,,,,,,,,Potassium channel family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000583,"[""bone marrow cancer cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000583,,,,,,,BrendaTissueOBO,,BTO:0000583,,,,,,,,,,,,,,,,,,,bone marrow cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000371,"[""THR670 in KIT(D816V)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000371,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR670 in KIT(D816V),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400222,"[""NKF1 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400222,,,,,,,,,,,,,,,,,,,,,,,,,,,,NKF1 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400013,"[""Olfactory receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400013,,,,,,,,,,,,,,,,,,,,,,,,,,,,Olfactory receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005277,"[""CAG cell""]",,CAG cell line; established from a bone marrow aspirate of a patient with myeloma.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000899,,,,,,,,CAG cell line; established from a bone marrow aspirate of a patient with myeloma.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005277,XPMUser,2012-02-06T11:24:05Z,,,,,BrendaTissueOBO,,BTO:0005277,,,,,,,,,,,,,,,,,,,CAG cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4610,"[""intestinal benign neoplasm""]",,A gastrointestinal system benign neoplasm that is located_in the intestine.,false,,,http://purl.obolibrary.org/obo/DOID_0050624,,,,,,,,A gastrointestinal system benign neoplasm that is located_in the intestine.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4610,,,,MESH:D007414|UMLS_CUI:C0021841|NCI:C3141|SNOMEDCT_US_2016_03_01:126769007,intestine growth|intestinal tumors|neoplasm of intestinal tract,,disease_ontology,,DOID:4610,,,,,,,,,,,,,,,,,,,intestinal benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003904,"[""HOS cell""]",,Homo sapiens bone osteosarcoma cell line; established from a 13-years-old caucasian female.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000407,,,,,,,,Homo sapiens bone osteosarcoma cell line; established from a 13-years-old caucasian female.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003904,,,,,,,BrendaTissueOBO,,BTO:0003904,,,,,,,,,,,,,,,,,,,HOS cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200056,"[""CCR4 gene""]",,"A C-C chemokine receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51679] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400095,,,,,,,,"A C-C chemokine receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51679] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200056,,,,,,,,,,,,,,,,1233,CCR4,CMKBR4,,,,,,,,,,CCR4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200672,"[""OR6X1 gene""]",,"An olfactory receptor 6X1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH79] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6X1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH79] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200672,,,,,,,,,,,,,,,,390260,OR6X1,,,,,,,,,,,OR6X1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001854,"[""vascular endothelial cell""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0001176|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001854,,,,,,,BrendaTissueOBO,,BTO:0001854,,,,,,,,,,,,,,,,,,,vascular endothelial cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100680,"[""Olfactory receptor 7d2""]",,"An olfactory receptor 7D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RA2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 7D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RA2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100680,,,,https://pharos.nih.gov/idg/targets/Q96RA2,,,,,,,,,,,,,OR7D2,,,Q96RA2,,,,,,,,Olfactory receptor 7d2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100539,"[""Transient receptor potential cation channel subfamily m member 6""]",,"transient receptor potential cation channel subfamily m member 6 (TRPM6)  with  no mutation  in a nonphosphorylated state|A transient receptor potential cation channel subfamily M member 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BX84] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300321,,,,,,,,"transient receptor potential cation channel subfamily m member 6 (TRPM6)  with  no mutation  in a nonphosphorylated state|A transient receptor potential cation channel subfamily M member 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BX84] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100539,,,,https://pharos.nih.gov/idg/targets/Q9BX84,,,,,,,,,,,,,TRPM6,CHAK2,,Q9BX84,,,,,,,,Transient receptor potential cation channel subfamily m member 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3451,"[""skin carcinoma""]",,A skin cancer that is located_in tissues of the skin and develops from epithelial cells.,false,,,http://purl.obolibrary.org/obo/DOID_305|http://purl.obolibrary.org/obo/DOID_4159,,,,,,,,A skin cancer that is located_in tissues of the skin and develops from epithelial cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3451,,,,UMLS_CUI:C0699893|NCI:C4914,carcinoma of skin,,disease_ontology,carcinoma of skin,DOID:3451,,,,,,,,,,,,,,,,,,,skin carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200005,"[""HTR1F gene""]",,"A 5-hydroxytryptamine receptor 1F that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30939] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402001,,,,,,,,"A 5-hydroxytryptamine receptor 1F that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30939] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200005,,,,,,,,,,,,,,,,3355,HTR1F,HTR1EL,,,,,,,,,,HTR1F gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001063,"[""phrenic nerve""]",,"A general motor and sensory nerve on each side of the body that arises chiefly from the fourth cervical nerve, passes down through the thorax to the diaphragm, and supplies or gives off branches supplying especially the pericardium, pleura, and diaphragm.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000925,,,,,,,,"A general motor and sensory nerve on each side of the body that arises chiefly from the fourth cervical nerve, passes down through the thorax to the diaphragm, and supplies or gives off branches supplying especially the pericardium, pleura, and diaphragm.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001063,,,,,,,BrendaTissueOBO,nervus phrenicus|phrenic|diaphragmatic nerve,BTO:0001063,,,,,,,,,,,,,,,,,,,phrenic nerve,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400216,"[""RET family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400216,,,,,,,,,,,,,,,,,,,,,,,,,,,,RET family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003860,"[""T/C-28a2 cell""]",,Human chondrocyte cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003858,,,,,,,,Human chondrocyte cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003860,,,,,,,BrendaTissueOBO,,BTO:0003860,,,,,,,,,,,,,,,,,,,T/C-28a2 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100325,"[""Olfactory receptor 10W1""]",,"An olfactory receptor 10W1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10W1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100325,,,,https://pharos.nih.gov/idg/targets/Q8NGF6,,,,,,,,,,,,,OR10W1,OR10W1P,,Q8NGF6,,,,,,,,Olfactory receptor 10W1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000467,"[""YSK4 kinase domain""]",,YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae); FLJ23074; MAP3K8; RCK; YSK4,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae); FLJ23074; MAP3K8; RCK; YSK4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000467,,,,,,,,,,,,,,,,,,,200467,,,,,,,,,YSK4 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100396,"[""[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial""]",,"A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15119] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300306,,,,,,,,"A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15119] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100396,,,,https://pharos.nih.gov/idg/targets/Q15119,,,,,,,,,,,,,PDK2,PDHK2,,Q15119,,,,,,,,"[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100149,"[""Adhesion G-protein coupled receptor D2""]",,"A G-protein coupled receptor 144 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z7M1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,"A G-protein coupled receptor 144 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z7M1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100149,,,,https://pharos.nih.gov/idg/targets/Q7Z7M1,,,,,,,,,,,,,GPR144,ADGRD2|PGR24,,Q7Z7M1,,,,,,,,Adhesion G-protein coupled receptor D2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200505,"[""STK39 gene""]",,"This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400302,,,,,,,,"This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200505,,,,,,,,,,,,,,,,27347,STK39,SPAK,,,,,,,,,,STK39 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0002116,"[""pterygium""]",,,false,,,http://purl.obolibrary.org/obo/DOID_10124,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0002116,laronhughes,2010-06-30T02:44:30Z,,ICD10CM:H11.00|ICD9CM:372.40|UMLS_CUI:C0033999|ICD9CM:372.4|ICD10CM:H11.0|SNOMEDCT_US_2016_03_01:193879003|SNOMEDCT_US_2016_03_01:193884009|MESH:D011625|ICD10CM:H11.009|SNOMEDCT_US_2016_03_01:155165000|SNOMEDCT_US_2016_03_01:77489003,surfer's eye,,disease_ontology,,DOID:0002116,,,,,,,,,,,,,,,,,,,pterygium,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200313,"[""OR10J3 gene""]",,"An olfactory receptor 10J3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5JRS4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10J3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5JRS4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200313,,,,,,,,,,,,,,,,441911,OR10J3,OR10J3P,,,,,,,,,,OR10J3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200120,"[""GABRG3 gene""]",,"This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. The protein encoded by this gene is a gamma subunit, which contains the benzodiazepine binding site. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400519,,,,,,,,"This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. The protein encoded by this gene is a gamma subunit, which contains the benzodiazepine binding site. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200120,,,,,,,,,,,,,,,,2567,GABRG3,,,,,,,,,,,GABRG3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000102,"[""N-palmitoylethanolamine""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_32952,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000102,,,,,,,,,,,,,,,,,,,,,,,,,,,,N-palmitoylethanolamine,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100072,"[""Corticotropin-releasing factor receptor 1""]",,"A corticotropin-releasing factor receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P34998] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300036,,,,,,,,"A corticotropin-releasing factor receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P34998] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100072,,,,https://pharos.nih.gov/idg/targets/P34998,,,,,,,,,,,,,CRHR1,CRFR|CRFR1|CRHR,,P34998,,,,,,,,Corticotropin-releasing factor receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100473,"[""Serine/threonine-protein kinase sgk3""]",,"serine/threonine-protein kinase sgk3 (SGK3)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase Sgk3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96BR1] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300224,,,,,,,,"serine/threonine-protein kinase sgk3 (SGK3)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase Sgk3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96BR1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100473,,,,https://pharos.nih.gov/idg/targets/Q96BR1,,,,,,,,,,,,,SGK3,CISK|SGKL,,Q96BR1,,,,,,,,Serine/threonine-protein kinase sgk3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000134,"[""EPHA2 kinase domain""]",,EPH receptor A2; ARCC2; ECK; EPHA2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,EPH receptor A2; ARCC2; ECK; EPHA2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000134,,,,,,,,,,,,,,,,,,,200136,,,,,,,,,EPHA2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200678,"[""OR7C1 gene""]",,"An olfactory receptor 7C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76099] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 7C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76099] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200678,,,,,,,,,,,,,,,,26664,OR7C1,OR7C4,,,,,,,,,,OR7C1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000303,"[""THR106 in MK11""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000303,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR106 in MK11,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0080079,"[""nonsyndromic congenital nail disorder 1""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4123,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0080079,lschriml,2015-11-09T15:13:08Z,,OMIM:161050,twenty-nail dystrophy,,disease_ontology,,DOID:0080079,,,,,,,,,,,,,,,,,,,nonsyndromic congenital nail disorder 1,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0080074,"[""neural tube defect""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0080015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0080074,lschriml,2015-10-19T14:41:42Z,,OMIM:301410|OMIM:601634,,,disease_ontology,,DOID:0080074,,,,,,,,,,,,,,,,,,,neural tube defect,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000236,"[""LIMK2 kinase domain""]",,LIM domain kinase 2; LIMK2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,LIM domain kinase 2; LIMK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000236,,,,,,,,,,,,,,,,,,,200226,,,,,,,,,LIMK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002206,"[""small cell lung cancer cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000762,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002206,,,,,,,BrendaTissueOBO,,BTO:0002206,,,,,,,,,,,,,,,,,,,small cell lung cancer cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300385,"[""CACNA1E subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300333,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300385,,,,,,,,,,,,,,,,,,,,,,,,,,,,CACNA1E subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005060,"[""UACC-903 cell""]",,Human melanoma cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0000849|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human melanoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005060,XPMUser,2011-03-05T09:56:22Z,,,,,BrendaTissueOBO,UACC 903 cell|UACC903 cell,BTO:0005060,,,,,,,,,,,,,,,,,,,UACC-903 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200457,"[""OR6C65 gene""]",,"An olfactory receptor 6C65 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NJZ3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6C65 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NJZ3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200457,,,,,,,,,,,,,,,,403282,OR6C65,,,,,,,,,,,OR6C65 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000073,"[""CDK15 kinase domain""]",,Cyclin-Dependent Kinase 15; serine/threonine-protein kinase ALS2CR7; PFTAIRE2; PFTK2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Cyclin-Dependent Kinase 15; serine/threonine-protein kinase ALS2CR7; PFTAIRE2; PFTK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000073,,,,,,,,,,,,,,,,,,,200317,,,,,,,,,CDK15 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000419,"[""STK16 kinase domain""]",,Serine/threonine kinase 16; FLJ39635; KRCT; MGC16211; MPSK; MPSK1; PKL12; STK16; TSF1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine kinase 16; FLJ39635; KRCT; MGC16211; MPSK; MPSK1; PKL12; STK16; TSF1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000419,,,,,,,,,,,,,,,,,,,200420,,,,,,,,,STK16 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300291,"[""MELK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300116,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300291,,,,,,,,,,,,,,,,,,,,,,,,,,,,MELK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200207,"[""GPR6 gene""]",,"A G-protein coupled receptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46095] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46095] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200207,,,,,,,,,,,,,,,,2830,GPR6,,,,,,,,,,,GPR6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200440,"[""PRPF4B gene""]",,"Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400150,,,,,,,,"Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200440,,,,,,,,,,,,,,,,8899,PRPF4B,KIAA0536|PRP4|PRP4H,,,,,,,,,,PRPF4B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13550,"[""angle-closure glaucoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1686,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13550,,,,SNOMEDCT_US_2016_03_01:270882001|UMLS_CUI:C0017605|SNOMEDCT_US_2016_03_01:392291006|SNOMEDCT_US_2016_03_01:193544008|SNOMEDCT_US_2016_03_01:33647009|MESH:D015812|NCI:C34639,Closed angle glaucoma|ACG - Angle-closure glaucoma|Angle-closure glaucoma (disorder)|Angle Closure Glaucoma|Narrow cleft glaucoma|primary open-angle glaucoma with narrow angles,,disease_ontology,,DOID:13550,,,,,,,,,,,,,,,,,,,angle-closure glaucoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200068,"[""CYSLTR2 gene""]",,"A cysteinyl leukotriene receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NS75] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400033,,,,,,,,"A cysteinyl leukotriene receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NS75] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200068,,,,,,,,,,,,,,,,57105,CYSLTR2,CYSLT2|CYSLT2R,,,,,,,,,,CYSLTR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200491,"[""STK32A gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400227,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200491,,,,,,,,,,,,,,,,202374,STK32A,YANK1,,,,,,,,,,STK32A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3781,"[""anovulation""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1100,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3781,,,,MESH:D000858|NCI:C34388|SNOMEDCT_US_2016_03_01:34571000|UMLS_CUI:C0003128,,,disease_ontology,,DOID:3781,,,,,,,,,,,,,,,,,,,anovulation,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100717,"[""Olfactory receptor 9I1""]",,"An olfactory receptor 9I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 9I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100717,,,,https://pharos.nih.gov/idg/targets/Q8NGQ6,,,,,,,,,,,,,OR9I1,,,Q8NGQ6,,,,,,,,Olfactory receptor 9I1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80296,"[""Urocortin II""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16081,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80296,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80296,,,,,Urocortin II,,CHEBI:80296,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13270,"[""erythropoietic protoporphyria""]",,"An acute porphyria characterized by a deficiency in the enzyme ferrochelatase, leading to abnormally high levels of protoporphyrin in the tissue.",false,,,http://purl.obolibrary.org/obo/DOID_3133,,,,,,,,"An acute porphyria characterized by a deficiency in the enzyme ferrochelatase, leading to abnormally high levels of protoporphyrin in the tissue.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13270,,,,UMLS_CUI:C0162568|ORDO:79278|ICD10CM:E80.0|OMIM:177000|OMIM:300752|SNOMEDCT_US_2016_03_01:51022005|NCI:C84698|MESH:D046351,Protoporphyria|EPP (erythropoietic protoporphyria porphyria)|Erythropoietic protoporphyria (disorder),,disease_ontology,,DOID:13270,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,erythropoietic protoporphyria,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200320,"[""TRPC1 gene""]",,"The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400577,,,,,,,,"The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200320,,,,,,,,,,,,,,,,7220,TRPC1,TRP1,,,,,,,,,,TRPC1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100338,"[""Transient receptor potential cation channel subfamily V member 6""]",,"A transient receptor potential cation channel subfamily V member 6 that is encoded in the genome of human. [PRO:HJD, UniProtKB:Q9H1D0] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300595,,,,,,,,"A transient receptor potential cation channel subfamily V member 6 that is encoded in the genome of human. [PRO:HJD, UniProtKB:Q9H1D0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100338,,,,https://pharos.nih.gov/idg/targets/Q9H1D0,,,,,,,,,,,,,TRPV6,ECAC2,,Q9H1D0,,,,,,,,Transient receptor potential cation channel subfamily V member 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003858,"[""chondrocyte cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003858,,,,,,,BrendaTissueOBO,,BTO:0003858,,,,,,,,,,,,,,,,,,,chondrocyte cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000946,"[""NT2/D1 cell""]",,Testis; metastatic site: lung malignant pluripotent embryonal carcinoma cell line. The NTERA-2 cl.D1 cell line is a pluripotent human testicular embryonal carcinoma cell line derived by cloning the NTERA-2 cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Testis; metastatic site: lung malignant pluripotent embryonal carcinoma cell line. The NTERA-2 cl.D1 cell line is a pluripotent human testicular embryonal carcinoma cell line derived by cloning the NTERA-2 cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000946,,,,,,,BrendaTissueOBO,NTERA-2 cl.D1 cell,BTO:0000946,,,,,,,,,,,,,,,,,,,NT2/D1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200668,"[""OR6Q1 gene""]",,"An olfactory receptor 6Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200668,,,,,,,,,,,,,,,,219952,OR6Q1,,,,,,,,,,,OR6Q1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100228,"[""Small conductance calcium-activated potassium channel protein 1""]",,"A small conductance calcium-activated potassium channel protein 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q92952] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300437,,,,,,,,"A small conductance calcium-activated potassium channel protein 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q92952] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100228,,,,https://pharos.nih.gov/idg/targets/Q92952,,,,,,,,,,,,,KCNN1,SK,,Q92952,,,,,,,,Small conductance calcium-activated potassium channel protein 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3211,"[""lysosomal storage disease""]",,An inherited metabolic disorder that involve an abnormal accumulation of substances inside the lysosome resulting from defects in lysosomal function.,false,,,http://purl.obolibrary.org/obo/DOID_655,,,,,,,,An inherited metabolic disorder that involve an abnormal accumulation of substances inside the lysosome resulting from defects in lysosomal function.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3211,,,,NCI:C61250|SNOMEDCT_US_2016_03_01:23585005|MESH:D016464|UMLS_CUI:C0085078,disorder of lysosomal enzyme (disorder)|lysosomal storage metabolism disorder|inborn lysosomal enzyme disorder,,disease_ontology,,DOID:3211,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,lysosomal storage disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001400,"[""tuber""]",,A short fleshy usually underground stem bearing minute scale leaves each of which bears a bud in its axil and is potentially able to produce a new plant.,false,,,http://purl.obolibrary.org/obo/BTO_0001300|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A short fleshy usually underground stem bearing minute scale leaves each of which bears a bud in its axil and is potentially able to produce a new plant.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001400,,,,,,,BrendaTissueOBO,,BTO:0001400,,,,,,,,,,,,,,,,,,,tuber,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9799,"[""eye degenerative disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1289|http://purl.obolibrary.org/obo/DOID_5614,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9799,,,,SNOMEDCT_US_2016_03_01:193275003|UMLS_CUI:C0154777|ICD10CM:H44.5|ICD9CM:360.2|ICD9CM:360.40|ICD9CM:360.4|SNOMEDCT_US_2016_03_01:62585004|ICD9CM:360.20|SNOMEDCT_US_2016_03_01:193285002|SNOMEDCT_US_2016_03_01:193292007|ICD10CM:H44.30|SNOMEDCT_US_2016_03_01:193279009,,,disease_ontology,,DOID:9799,,,,,,,,,,,,,,,,,,,eye degenerative disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3093,"[""nervous system cancer""]",,An organ system cancer located_in the nervous system that affects the central or peripheral nervous system.,false,,,http://purl.obolibrary.org/obo/DOID_0050686,,,,,,,,An organ system cancer located_in the nervous system that affects the central or peripheral nervous system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3093,,,DOID:3195|DOID:4695|DOID:1193,NCI:C35562|UMLS_CUI:C1334956|UMLS_CUI:C0153643|MESH:D009380|SNOMEDCT_US_2016_03_01:188306000|UMLS_CUI:C0027665|ICD9CM:192|ICD9CM:192.9,tumor of the nervous system|nervous system neoplasm|neural tumor|neoplasm of nervous system (disorder)|neural neoplasm|malignant neoplasm of nervous system,,disease_ontology,,DOID:3093,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,nervous system cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300222,"[""NKF1 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300222,,,,,,,,,,,,,,,,,,,,,,,,,,,,NKF1 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100588,"[""Hexokinase-2""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100588,,,,,,,,,,,,,,,,,HK2,,,P52789,,,,,,,,Hexokinase-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200694,"[""OR8G1 gene""]",,"An olfactory receptor 8G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15617] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 8G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15617] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200694,,,,,,,,,,,,,,,,26494,OR8G1,OR8G1P,,,,,,,,,,OR8G1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000050,"[""LEU132 in GSK3B""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000050,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU132 in GSK3B,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005688,"[""shoot meristem""]",,"The tissue that produces all aerial parts of the plant, which include the stem as well as lateral structures, such as leaves and flowers.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000852,,,,,,,,"The tissue that produces all aerial parts of the plant, which include the stem as well as lateral structures, such as leaves and flowers.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005688,Marion,2014-10-21T10:32:19Z,,,,,BrendaTissueOBO,,BTO:0005688,,,,,,,,,,,,,,,,,,,shoot meristem,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000954,"[""nymph""]",,"Any of various immature insects; especially: a larva of an insect (as a grasshopper, true bug, or mayfly) with incomplete metamorphosis that differs from the imago especially in size and in its incompletely developed wings and genitalia.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000707,,,,,,,,"Any of various immature insects; especially: a larva of an insect (as a grasshopper, true bug, or mayfly) with incomplete metamorphosis that differs from the imago especially in size and in its incompletely developed wings and genitalia.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000954,,,,,,,BrendaTissueOBO,,BTO:0000954,,,,,,,,,,,,,,,,,,,nymph,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000174,"[""embryonic structure""]",,"An anatomical structure that exists only before the organism is fully formed. In mammals, for example, a structure that exists only prior to the birth of the organism. This structure may be normal or abnormal.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001489|http://purl.obolibrary.org/obo/BTO_0000284,,,,,,,,"An anatomical structure that exists only before the organism is fully formed. In mammals, for example, a structure that exists only prior to the birth of the organism. This structure may be normal or abnormal.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000174,,,,,,,BrendaTissueOBO,embryonale Struktur,BTO:0000174,,,,,,,,,,,,,,,,,,,embryonic structure,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000278,"[""PHE79 in CDKL3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000278,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE79 in CDKL3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5828,"[""endometrioid ovary carcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3713,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5828,,,,SNOMEDCT_US_2016_03_01:254852002|UMLS_CUI:C0346163|NCI:C7979,endometrioid carcinoma ovary (disorder)|Ovarian endometrioid carcinoma,,disease_ontology,endometrioid carcinoma of ovary,DOID:5828,,,,,,,,,,,,,,,,,,,endometrioid ovary carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100425,"[""Olfactory receptor 52k1""]",,"An olfactory receptor 52K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 52K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100425,,,,https://pharos.nih.gov/idg/targets/Q8NGK4,,,,,,,,,,,,,OR52K1,,,Q8NGK4,,,,,,,,Olfactory receptor 52k1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200185,"[""KCNA6 gene""]",,"Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400537,,,,,,,,"Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200185,,,,,,,,,,,,,,,,3742,KCNA6,,,,,,,,,,,KCNA6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100587,"[""Hexokinase-3""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100587,,,,,,,,,,,,,,,,,HK3,,,P52790,,,,,,,,Hexokinase-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200802,"[""TAAR2 gene""]",,"A trace amine-associated receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9P1P5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A trace amine-associated receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9P1P5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200802,,,,,,,,,,,,,,,,9287,TAAR2,GPR58,,,,,,,,,,TAAR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300557,"[""Kv10.2/KCNH5 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300448,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300557,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv10.2/KCNH5 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100319,"[""Mitogen-activated protein kinase 7""]",,"A mitogen-activated protein kinase 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13164] |mitogen-activated protein kinase 7 (ERK5)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300292,,,,,,,,"A mitogen-activated protein kinase 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13164] |mitogen-activated protein kinase 7 (ERK5)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100319,,,,https://pharos.nih.gov/idg/targets/Q13164,,,,,,,,,,,,,MAPK7,BMK1|ERK5|PRKM7,,Q13164,,,,,,,,Mitogen-activated protein kinase 7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300537,"[""Kv1.6/KCNA6 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300436,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300537,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv1.6/KCNA6 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117514,"[""Steroid hormone receptor err2""]",,"A steroid hormone receptor ERR2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95718] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117473,,,,,,,,"A steroid hormone receptor ERR2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95718] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117514,,,,https://pharos.nih.gov/idg/targets/O95718,,,,,,,,,,,,,ESRRB,ESRL2,,O95718,,,,,,,,Steroid hormone receptor err2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100039,"[""Brain-specific angiogenesis inhibitor 1""]",,"A brain-specific angiogenesis inhibitor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14514] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,"A brain-specific angiogenesis inhibitor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14514] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100039,,,,https://pharos.nih.gov/idg/targets/O14514,,,,,,,,,,,,,BAI1,ADGRB1,,O14514,,,,,,,,Brain-specific angiogenesis inhibitor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491002,"[""ATP-dependent PFK group I subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491016,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491002,,,,,,,,,,,,,,,,,,,,,,,,,,,,ATP-dependent PFK group I subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1786,"[""adrenal rest tumor""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060089,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1786,,,,SNOMEDCT_US_2016_03_01:54292009|MESH:D000314|UMLS_CUI:C0001630|NCI:C2860,Adrenal Rest neoplasm,,disease_ontology,,DOID:1786,,,,,,,,,,,,,,,,,,,adrenal rest tumor,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300202,"[""NKF4 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300202,,,,,,,,,,,,,,,,,,,,,,,,,,,,NKF4 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100480,"[""Snf-related serine/threonine-protein kinase""]",,"An SNF-related serine/threonine-protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NRH2] |SNF-related serine/threonine-protein kinase (SNRK)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03391038,,,,,,,,"An SNF-related serine/threonine-protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NRH2] |SNF-related serine/threonine-protein kinase (SNRK)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100480,,,,https://pharos.nih.gov/idg/targets/Q9NRH2,,,,,,,,,,,,,SNRK,KIAA0096|SNFRK,,Q9NRH2,,,,,,,,Snf-related serine/threonine-protein kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400207,"[""PIM family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400207,,,,,,,,,,,,,,,,,,,,,,,,,,,,PIM family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100236,"[""Protein kinase c alpha type""]",,"A protein kinase C alpha type that is encoded in the genome of human. [PRO:CL, UniProtKB:P17252] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300276,,,,,,,,"A protein kinase C alpha type that is encoded in the genome of human. [PRO:CL, UniProtKB:P17252] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100236,,,,https://pharos.nih.gov/idg/targets/P17252,,,,,,,,,,,,,PRKCA,PKCA|PRKACA,,P17252,,,,,,,,Protein kinase c alpha type,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000427,"[""VAL804 in RET(M918T)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000427,,,,,,,,,,,,,,,,,,,,,,,,,,,,VAL804 in RET(M918T),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100514,"[""Putative olfactory receptor 2B3""]",,"An olfactory receptor 2B3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76000] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2B3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76000] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100514,,,,https://pharos.nih.gov/idg/targets/O76000,,,,,,,,,,,,,OR2B3,OR2B3P,,O76000,,,,,,,,Putative olfactory receptor 2B3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200028,"[""ASIC4 gene""]",,"This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. [provided by RefSeq, Feb 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400379,,,,,,,,"This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. [provided by RefSeq, Feb 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200028,,,,,,,,,,,,,,,,55515,ASIC4,ACCN4,,,,,,,,,,ASIC4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_63000000,"[""pfam domain""]",,Pfam is a database of protein families that includes their annotations and multiple sequence alignments generated using hidden Markov models|The kinase domain information from the pfam database.,false,,,http://www.w3.org/2002/07/owl#Thing,,,,,,,,Pfam is a database of protein families that includes their annotations and multiple sequence alignments generated using hidden Markov models|The kinase domain information from the pfam database.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_63000000,,,,,,,,,,,,,,,,,,,,,,,,,,,,pfam domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100513,"[""Olfactory receptor 2B2""]",,"An olfactory receptor 2B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZK3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZK3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100513,,,,https://pharos.nih.gov/idg/targets/Q9GZK3,,,,,,,,,,,,,OR2B2,OR2B9,,Q9GZK3,,,,,,,,Olfactory receptor 2B2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200517,"[""OR2B11 gene""]",,"An olfactory receptor 2B11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5JQS5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2B11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5JQS5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200517,,,,,,,,,,,,,,,,127623,OR2B11,,,,,,,,,,,OR2B11 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000174,"[""MET451 in MAST1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000174,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET451 in MAST1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400262,"[""CDK7 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400136,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400262,,,,,,,,,,,,,,,,,,,,,,,,,,,,CDK7 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100409,"[""Olfactory receptor 52A4""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100409,,,,https://pharos.nih.gov/idg/targets/A6NMU1,,,,,,,,,,,,,OR52A4,OR52A4P,,A6NMU1,,,,,,,,Olfactory receptor 52A4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200584,"[""OR4E1 gene""]",,"An olfactory receptor 4E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C645] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C645] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200584,,,,,,,,,,,,,,,,26687,OR4E1,OR4E1P,,,,,,,,,,OR4E1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200398,"[""PDK4 gene""]",,"This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400131,,,,,,,,"This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200398,,,,,,,,,,,,,,,,5166,PDK4,PDHK4,,,,,,,,,,PDK4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10609,"[""rickets""]",,"A bone remodeling disease that has_material_basis_in impaired mineralization or calcification of bones before epiphyseal closure due to deficiency or impaired metabolism of vitamin D, phosphorus or calcium which results_in softening and deformity located_in bone.",false,,,http://purl.obolibrary.org/obo/DOID_0080005,,,,,,,,"A bone remodeling disease that has_material_basis_in impaired mineralization or calcification of bones before epiphyseal closure due to deficiency or impaired metabolism of vitamin D, phosphorus or calcium which results_in softening and deformity located_in bone.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10609,,,DOID:11672,SNOMEDCT_US_2016_03_01:190640006|MESH:D012279|NCI:C26878|ORDO:289157|OMIM:277440|ICD10CM:E55.0|UMLS_CUI:C0221468|OMIM:264700|SNOMEDCT_US_2016_03_01:68295002|ICD9CM:268.0|SNOMEDCT_US_2016_03_01:154728003|SNOMEDCT_US_2016_03_01:190639009|OMIM:600785|UMLS_CUI:C0035579|OMIM:600081|SNOMEDCT_US_2016_03_01:41345002,vitamin D hydroxylation-deficient rickets|active rickets|vitamin D-dependent rickets,,disease_ontology,,DOID:10609,,,,,,,,,,,,,,,,,Xref MGI.,,rickets,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10600,"[""chronic tic disorder""]",,"A tic disorder that is characterized by single or multiple motor or phonic tics, but not both, which are present for more than a year.",false,,,http://purl.obolibrary.org/obo/DOID_2769,,,,,,,,"A tic disorder that is characterized by single or multiple motor or phonic tics, but not both, which are present for more than a year.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10600,,,,ICD10CM:F95.1|SNOMEDCT_US_2016_03_01:192623005|NCI:C116768|MESH:D013981|ICD9CM:307.22|UMLS_CUI:C0008701,chronic motor or vocal tic disorder,,disease_ontology,,DOID:10600,,,,,,,,,,,,,,,,,,,chronic tic disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10605,"[""short bowel syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5295,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10605,,,,SNOMEDCT_US_2016_03_01:235724004|SNOMEDCT_US_2016_03_01:204768009|MESH:D012778|NCI:C99059|SNOMEDCT_US_2016_03_01:26629001|UMLS_CUI:C0036992,acquired short bowel syndrome|short gut syndrome,,disease_ontology,,DOID:10605,,,,,,,,,,,,,,,,,,,short bowel syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10602,"[""steatorrhea""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5295,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10602,,,,SNOMEDCT_US_2016_03_01:197489007|NCI:C86917|UMLS_CUI:C0038238|MESH:D045602|SNOMEDCT_US_2016_03_01:27868004|SNOMEDCT_US_2016_03_01:66187002|SNOMEDCT_US_2016_03_01:266481005,Fatty stool (finding),,disease_ontology,,DOID:10602,,,,,,,,,,,,,,,,,,,steatorrhea,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10608,"[""celiac disease""]",,"An autoimmune disease of gastrointestinal tract that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite.",false,,,http://purl.obolibrary.org/obo/DOID_0060031,,,,,,,,"An autoimmune disease of gastrointestinal tract that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10608,,,,OMIM:609753|OMIM:612006|OMIM:612011|OMIM:612005|UMLS_CUI:C0007570|SNOMEDCT_US_2016_03_01:197481005|OMIM:607202|OMIM:612009|SNOMEDCT_US_2016_03_01:396331005|SNOMEDCT_US_2016_03_01:155842007|SNOMEDCT_US_2016_03_01:23829007|EFO:0001060|ORDO:555|ICD10CM:K90.0|SNOMEDCT_US_2016_03_01:197477005|OMIM:612007|OMIM:609755|OMIM:609754|MESH:D002446|NCI:C26714|OMIM:612008|ICD9CM:579.0|SNOMEDCT_US_2016_03_01:266478000|OMIM:212750|OMIM:611598,coeliac disease|celiac sprue|idiopathic steatorrhea,,disease_ontology,,DOID:10608,,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,celiac disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10603,"[""glucose intolerance""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4195,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10603,,,,UMLS_CUI:C0271650|SNOMEDCT_US_2016_03_01:190752008|ICD10CM:R73.09|SNOMEDCT_US_2016_03_01:9414007|MESH:D018149|NCI:C34646|SNOMEDCT_US_2016_03_01:154720005|SNOMEDCT_US_2016_03_01:267426009,Malabsorption of glucose (disorder)|Glucose: [intolerance] or [malabsorption],,disease_ontology,,DOID:10603,,,,,,,,,,,,,,,,,,,glucose intolerance,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391005,"[""Type II PI4K subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391009,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391005,,,,,,,,,,,,,,,,,,,,,,,,,,,,Type II PI4K subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300591,"[""TRPV2 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300484,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300591,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPV2 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200009,"[""HTR4 gene""]",,"A 5-hydroxytryptamine receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13639] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402003,,,,,,,,"A 5-hydroxytryptamine receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13639] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200009,,,,,,,,,,,,,,,,3360,HTR4,,,,,,,,,,,HTR4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300365,"[""Gap junction-forming innexin (innexin) family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300365,,,,,,,,,,,,,,,,,,,,,,,,,,,,Gap junction-forming innexin (innexin) family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1766,"[""factitious disorder""]",,"A disease of mental health where symptoms are deliberately produced, feigned or exaggerated in order to falsely demonstrate the presence of an illness.",false,,,http://purl.obolibrary.org/obo/DOID_150,,,,,,,,"A disease of mental health where symptoms are deliberately produced, feigned or exaggerated in order to falsely demonstrate the presence of an illness.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1766,,,,UMLS_CUI:C0015481|ICD9CM:300.16|ICD10CM:F68.11|SNOMEDCT_US_2016_03_01:430751001|SNOMEDCT_US_2016_03_01:31122002,Munchausen syndrome ,,disease_ontology,,DOID:1766,,,,,,,,,,,,,,,,,,,factitious disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5100,"[""middle ear disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2742,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5100,,,,SNOMEDCT_US_2016_03_01:232250008|SNOMEDCT_US_2016_03_01:68996008|SNOMEDCT_US_2016_03_01:194327004|NCI:C27065|SNOMEDCT_US_2016_03_01:155260002|SNOMEDCT_US_2016_03_01:300195001|UMLS_CUI:C0271428,,,disease_ontology,,DOID:5100,,,,,,,,,,,,,,,,,,,middle ear disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200136,"[""GRIA4 gene""]",,"Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA-&gt;GGA; R-&gt;G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400413,,,,,,,,"Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA-&gt;GGA; R-&gt;G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200136,,,,,,,,,,,,,,,,2893,GRIA4,GLUR4,,,,,,,,,,GRIA4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200586,"[""HKDC1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200586,,,,,,,,,,,,,,,,,,,,,,,,,,,,HKDC1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100061,"[""C-c chemokine receptor type 9""]",,"A C-C chemokine receptor type 9 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51686] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300095,,,,,,,,"A C-C chemokine receptor type 9 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51686] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100061,,,,https://pharos.nih.gov/idg/targets/P51686,,,,,,,,,,,,,CCR9,GPR28,,P51686,,,,,,,,C-c chemokine receptor type 9,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200412,"[""OR52B4 gene""]",,"An olfactory receptor 52B4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 52B4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200412,,,,,,,,,,,,,,,,143496,OR52B4,,,,,,,,,,,OR52B4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300021,"[""Melanocortin receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300021,,,,,,,,,,,,,,,,,,,,,,,,,,,,Melanocortin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9074,"[""systemic lupus erythematosus""]",,"A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart.",false,,,http://purl.obolibrary.org/obo/DOID_1575|http://purl.obolibrary.org/obo/DOID_8857,,,,,,,,"A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9074,,,,OMIM:610927|ICD10CM:M32|NCI:C3201|OMIM:152700|MESH:D008180|ICD10CM:M32.9|OMIM:608437|SNOMEDCT_US_2016_03_01:156450004|OMIM:609903|OMIM:612253|OMIM:605218|EFO:0002690|OMIM:601744|SNOMEDCT_US_2016_03_01:201435004|OMIM:610066|OMIM:612254|ORDO:536|OMIM:613145|OMIM:610065|OMIM:612378|OMIM:605480|OMIM:609939|OMIM:300809|SNOMEDCT_US_2016_03_01:55464009|OMIM:612251|ICD9CM:710.0|KEGG:05322|SNOMEDCT_US_2016_03_01:201439005|UMLS_CUI:C0024141|OMIM:614420,"Lupus Erythematosus, systemic|disseminated lupus erythematosus|SLE - Lupus Erythematosus, systemic",,disease_ontology,,DOID:9074,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,systemic lupus erythematosus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001207,"[""sarcoma cell""]",,"A malignant neoplasm cell arising in tissue of mesodermal origin, as connective tissue, bone, cartilage, or striated muscle.",false,,,http://purl.obolibrary.org/obo/BTO_0001801|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000372,,,,,,,,"A malignant neoplasm cell arising in tissue of mesodermal origin, as connective tissue, bone, cartilage, or striated muscle.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001207,,,,,,,BrendaTissueOBO,,BTO:0001207,,,,,,,,,,,,,,,,,,,sarcoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391022,"[""Phosphoenolpyruvate carboxykinase [GTP] family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300324,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391022,,,,,,,,,,,,,,,,,,,,,,,,,,,,Phosphoenolpyruvate carboxykinase [GTP] family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200376,"[""OBSCN gene""]",,"The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400168,,,,,,,,"The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200376,,,,,,,,,,,,,,,,84033,OBSCN,KIAA1556|KIAA1639,,,,,,,,,,OBSCN gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300502,"[""Beta-1/CHRNB1 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300502,,,,,,,,,,,,,,,,,,,,,,,,,,,,Beta-1/CHRNB1 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002878,"[""B-lymphoblastoid cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001528,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002878,,,,,,,BrendaTissueOBO,B lymphoblastoid cell,BTO:0002878,,,,,,,,,,,,,,,,,,,B-lymphoblastoid cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100541,"[""Olfactory receptor 2m4""]",,"An olfactory receptor 2M4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R27] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2M4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R27] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100541,,,,https://pharos.nih.gov/idg/targets/Q96R27,,,,,,,,,,,,,OR2M4,,,Q96R27,,,,,,,,Olfactory receptor 2m4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000707,"[""larva""]",,"1: The immature, wingless, and often wormlike feeding form that hatches from the egg of many insects, alters chiefly in size while passing through several molts, and is finally transformed into a pupa or chrysalis from which the adult emerges. 2: The early form of an animal (as a frog or sea urchin) that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000174,,,,,,,,"1: The immature, wingless, and often wormlike feeding form that hatches from the egg of many insects, alters chiefly in size while passing through several molts, and is finally transformed into a pupa or chrysalis from which the adult emerges. 2: The early form of an animal (as a frog or sea urchin) that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000707,,,,,,,BrendaTissueOBO,,BTO:0000707,,,,,,,,,,,,,,,,,,,larva,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000070,"[""CDC2L5 kinase domain""]",,Cyclin-dependent kinase 13; CDC2L; CDC2L5; CDK13; CHED; FLJ35215; KIAA1791,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Cyclin-dependent kinase 13; CDC2L; CDC2L5; CDK13; CHED; FLJ35215; KIAA1791,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000070,,,,,,,,,,,,,,,,,,,200073,,,,,,,,,CDC2L5 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9446,"[""cholangitis""]",,A bile duct disease that is an inflammation of the bile duct.,false,,,http://purl.obolibrary.org/obo/DOID_4138,,,,,,,,A bile duct disease that is an inflammation of the bile duct.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9446,,,,ICD9CM:576.1|SNOMEDCT_US_2016_03_01:197445007|SNOMEDCT_US_2016_03_01:82403002|NCI:C26718|SNOMEDCT_US_2016_03_01:155831003|UMLS_CUI:C0008311|MESH:D002761|ICD10CM:K83.0,,,disease_ontology,,DOID:9446,,,,,,,,,,,,,,,,,,,cholangitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100657,"[""Olfactory receptor 6c4""]",,"An olfactory receptor 6C4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6C4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100657,,,,https://pharos.nih.gov/idg/targets/Q8NGE1,,,,,,,,,,,,,OR6C4,,,Q8NGE1,,,,,,,,Olfactory receptor 6c4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400333,"[""Calcium channel alpha-1 subunit family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400333,,,,,,,,,,,,,,,,,,,,,,,,,,,,Calcium channel alpha-1 subunit family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9988,"[""tertiary neurosyphilis""]",,A tertiary syphilis that results_in infection located_in brain or located_in spinal cord.,false,,,http://purl.obolibrary.org/obo/DOID_8200,,,,,,,,A tertiary syphilis that results_in infection located_in brain or located_in spinal cord.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9988,,,,MESH:D009494|SNOMEDCT_US_2016_03_01:26039008|SNOMEDCT_US_2016_03_01:186895005|ICD9CM:094|SNOMEDCT_US_2016_03_01:266210001|ICD9CM:094.9|UMLS_CUI:C0027927|SNOMEDCT_US_2016_03_01:187356008|ICD10CM:A52.3|SNOMEDCT_US_2016_03_01:154384001|SNOMEDCT_US_2016_03_01:186884004|NCI:C84935,late neurosyphilis,,disease_ontology,,DOID:9988,http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease|http://purl.obolibrary.org/obo/doid#sexually_transmitted_infectious_disease,,,,,,,,,,,,,,,,,,tertiary neurosyphilis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5330,"[""dental pulp disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1091|http://purl.obolibrary.org/obo/DOID_65,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5330,,,,SNOMEDCT_US_2016_03_01:57203004|MESH:D003788|UMLS_CUI:C0011405|NCI:C34530,disorder of pulp of tooth (disorder)|pulp disorder|Dental pulp disorder,,disease_ontology,,DOID:5330,,,,,,,,,,,,,,,,,,,dental pulp disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200712,"[""OR9A2 gene""]",,"An olfactory receptor 9A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 9A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200712,,,,,,,,,,,,,,,,135924,OR9A2,,,,,,,,,,,OR9A2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100351,"[""Myosin-iiia""]",,"A myosin-IIIa that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NEV4] |myosin-IIIa (MYO3A)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300298,,,,,,,,"A myosin-IIIa that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NEV4] |myosin-IIIa (MYO3A)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100351,,,,https://pharos.nih.gov/idg/targets/Q8NEV4,,,,,,,,,,,,,MYO3A,,,Q8NEV4,,,,,,,,Myosin-iiia,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200502,"[""STK35 gene""]",,"The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400202,,,,,,,,"The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200502,,,,,,,,,,,,,,,,140901,STK35,CLIK1|PDIK1|STK35L1,,,,,,,,,,STK35 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005120,"[""neuroectodermal tumor cell""]",,A neuroectodermal tumor is a tumor of the central or peripheral nervous system.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A neuroectodermal tumor is a tumor of the central or peripheral nervous system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005120,XPMUser,2011-05-05T12:29:28Z,,,,,BrendaTissueOBO,,BTO:0005120,,,,,,,,,,,,,,,,,,,neuroectodermal tumor cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391040,"[""Ephrin family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391040,,,,,,,,,,,,,,,,,,,,,,,,,,,,Ephrin family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000382,"[""THR693 in EPHB4""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000382,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR693 in EPHB4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100487,"[""Srsf protein kinase 2""]",,"An SRSF protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P78362] |SRSF protein kinase 2 (SRPK2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300226,,,,,,,,"An SRSF protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P78362] |SRSF protein kinase 2 (SRPK2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100487,,,,https://pharos.nih.gov/idg/targets/P78362,,,,,,,,,,,,,SRPK2,,,P78362,,,,,,,,Srsf protein kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300314,"[""QIK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300116,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300314,,,,,,,,,,,,,,,,,,,,,,,,,,,,QIK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8913,"[""dermatophytosis""]",,"A cutaneous mycosis that results_in fungal infection located_in scalp, located_in glabrous skin, or located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which have the ability to utilize keratin as a nutrient source.",false,,,http://purl.obolibrary.org/obo/DOID_0050134,,,,,,,,"A cutaneous mycosis that results_in fungal infection located_in scalp, located_in glabrous skin, or located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which have the ability to utilize keratin as a nutrient source.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8913,,,,UMLS_CUI:C0011636|SNOMEDCT_US_2016_03_01:187474000|NCI:C26745|ICD9CM:110|ICD10CM:B35.9|SNOMEDCT_US_2016_03_01:154394006|ICD9CM:110.9|ICD10CM:B35|SNOMEDCT_US_2016_03_01:47382004|SNOMEDCT_US_2016_03_01:186984003|SNOMEDCT_US_2016_03_01:266214005|SNOMEDCT_US_2016_03_01:186998006,,,disease_ontology,,DOID:8913,,,,,,,,,,,,,,,,,,,dermatophytosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003957,"[""N-9 cell""]",,Murine microglial cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0003349|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Murine microglial cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003957,,,,,,,BrendaTissueOBO,N9 cell,BTO:0003957,,,,,,,,,,,,,,,,,,,N-9 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300269,"[""GCN2 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300151,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300269,,,,,,,,,,,,,,,,,,,,,,,,,,,,GCN2 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200116,"[""DYRK3 gene""]",,"This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400267,,,,,,,,"This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200116,,,,,,,,,,,,,,,,8444,DYRK3,,,,,,,,,,,DYRK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5078,"[""ganglioglioma""]",,A cell type benign neoplasm that has_material_basis_in glial-type cells.,false,,,http://purl.obolibrary.org/obo/DOID_0060084|http://purl.obolibrary.org/obo/DOID_0060115|http://purl.obolibrary.org/obo/DOID_331,,,,,,,,A cell type benign neoplasm that has_material_basis_in glial-type cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5078,,,DOID:5607|DOID:5606,SNOMEDCT_US_2016_03_01:89880005|NCI:C27362|MESH:D018303|UMLS_CUI:C0206716|UMLS_CUI:C1332202|NCI:C3788|NCI:C27363|SNOMEDCT_US_2016_03_01:87191000119100|UMLS_CUI:C1332969,childhood ganglioglioma|adult ganglioglioma|CNS ganglioglioma,,disease_ontology,,DOID:5078,,,,,,,,,,,,,,,,,,,ganglioglioma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4252,"[""Alexander disease""]",,A leukodystrophy that is characterized by the destruction of white matter and the formation of Rosenthal fibers consisting of abnormal clumps of protein that accumulate in astrocytes.,false,,,http://purl.obolibrary.org/obo/DOID_10579,,,,,,,,A leukodystrophy that is characterized by the destruction of white matter and the formation of Rosenthal fibers consisting of abnormal clumps of protein that accumulate in astrocytes.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4252,,,,NCI:C84545|UMLS_CUI:C0270726|SNOMEDCT_US_2016_03_01:81854007|OMIM:203450|MESH:D038261,Alexander's disease,,disease_ontology,,DOID:4252,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Alexander disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300054,"[""Adrenomedullin receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300054,,,,,,,,,,,,,,,,,,,,,,,,,,,,Adrenomedullin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200287,"[""MAP3K5 gene""]",,"Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400186,,,,,,,,"Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200287,,,,,,,,,,,,,,,,4217,MAP3K5,ASK1|MAPKKK5|MEKK5,,,,,,,,,,MAP3K5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000134,"[""bloodstream form""]",,When living in the mammalian bloodstream T. brucei has neither a functional Krebs cycle nor oxidative phosphorylation nor does it store any carbohydrates. In the bloodstream form. Its metabolism is restricted to the glycolytic pathway alone.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000092,,,,,,,,When living in the mammalian bloodstream T. brucei has neither a functional Krebs cycle nor oxidative phosphorylation nor does it store any carbohydrates. In the bloodstream form. Its metabolism is restricted to the glycolytic pathway alone.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000134,,,,,,,BrendaTissueOBO,,BTO:0000134,,,,,,,,,,,,,,,,,,,bloodstream form,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200503,"[""STK36 gene""]",,"This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400228,,,,,,,,"This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200503,,,,,,,,,,,,,,,,27148,STK36,KIAA1278,,,,,,,,,,STK36 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_81568,"[""Luteinizing hormone""]",ICSH|LH|Interstitial cell stimulating hormone,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,CAS:9002-67-9|KEGG:C18183,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,ICSH|LH|Interstitial cell stimulating hormone,,,CHEBI:81568,,,,,,,,,,,,,,,,,,,,,,,CHEBI:81568,,,,,Luteinizing hormone,,CHEBI:81568,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200113,"[""GABRB1 gene""]",,"The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400512,,,,,,,,"The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200113,,,,,,,,,,,,,,,,2560,GABRB1,,,,,,,,,,,GABRB1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000749,"[""sporozoan form""]",,Any of a large class (Sporozoa) of strictly parasitic protozoans that have a complicated life cycle usually involving both asexual and sexual generations often in different hosts and include important pathogens (as malaria parasites and babesias).,false,,,http://purl.obolibrary.org/obo/BTO_0002503|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Any of a large class (Sporozoa) of strictly parasitic protozoans that have a complicated life cycle usually involving both asexual and sexual generations often in different hosts and include important pathogens (as malaria parasites and babesias).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000749,,,,,,,BrendaTissueOBO,sporozoa,BTO:0000749,,,,,,,,,,,,,,,,,,,sporozoan form,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000102,"[""MET108 in JNK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000102,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET108 in JNK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100601,"[""Adenylate kinase 9""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100601,,,,,,,,,,,,,,,,,AK9,,,Q5TCS8,,,,,,,,Adenylate kinase 9,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001228,"[""seedling""]",,The embryonic product of the germination of a seed. The young shoot and root axis.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000720,,,,,,,,The embryonic product of the germination of a seed. The young shoot and root axis.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001228,,,,,,,BrendaTissueOBO,,BTO:0001228,,,,,,,,,,,,,,,,,,,seedling,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005436,"[""panicle""]",,"A branched indeterminate inflorescence in which the branches are racemes, so that each flower has its own stalk attached to the branch. Oats and sorghum have panicles.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000628,,,,,,,,"A branched indeterminate inflorescence in which the branches are racemes, so that each flower has its own stalk attached to the branch. Oats and sorghum have panicles.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005436,XPMUser,2013-04-18T11:08:50Z,,,,,BrendaTissueOBO,,BTO:0005436,,,,,,,,,,,,,,,,,,,panicle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100181,"[""Potassium voltage-gated channel subfamily A member 2""]",,A voltage-gated potassium channel subunit KCNA2 that is encoded in the genome of human. [] ,false,,,http://www.drugtargetontology.org/dto/DTO_01300533,,,,,,,,A voltage-gated potassium channel subunit KCNA2 that is encoded in the genome of human. [] ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100181,,,,https://pharos.nih.gov/idg/targets/P16389,,,,,,,,,,,,,KCNA2,,,P16389,,,,,,,,Potassium voltage-gated channel subfamily A member 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200105,"[""FXYD7 gene""]",,"This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Dec 2000]",false,,,http://www.drugtargetontology.org/dto/DTO_01400348,,,,,,,,"This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Dec 2000]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200105,,,,,,,,,,,,,,,,53822,FXYD7,,,,,,,,,,,FXYD7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100358,"[""Olfactory receptor 2a12""]",,"An olfactory receptor 2A12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2A12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100358,,,,https://pharos.nih.gov/idg/targets/Q8NGT7,,,,,,,,,,,,,OR2A12,OR2A12P,,Q8NGT7,,,,,,,,Olfactory receptor 2a12,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6457,"[""Cowden disease""]",,"An autosomal dominant disease characterized by multiple noncancerous, tumor-like growths (hamartomas) and an increased risk of certain forms of cancer, especially breast, thyroid and endometrium. It is caused  by mutations in the PTEN, SDHB, SDHD and KLLN genes.",false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,"An autosomal dominant disease characterized by multiple noncancerous, tumor-like growths (hamartomas) and an increased risk of certain forms of cancer, especially breast, thyroid and endometrium. It is caused  by mutations in the PTEN, SDHB, SDHD and KLLN genes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6457,,,DOID:3471,SNOMEDCT_US_2016_03_01:67944007|ORDO:201|OMIM:615109|NCI:C3076|OMIM:615108|NCI:C8419|UMLS_CUI:C0018553|OMIM:612359|UMLS_CUI:C0391826|MESH:D006223|OMIM:615106|OMIM:158350|SNOMEDCT_US_2016_03_01:58037000|OMIM:615107,dysplastic Gangliocytoma of Cerebellum|Lhermitte-Duclos disease (disorder),,disease_ontology,multiple hamartoma syndrome,DOID:6457,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].
",,Cowden disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000387,"[""endocardium""]",,A thin serous membrane lining the cavities of the heart.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A thin serous membrane lining the cavities of the heart.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000387,,,,,,,BrendaTissueOBO,,BTO:0000387,,,,,,,,,,,,,,,,,,,endocardium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400387,"[""CACNA1G subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400333,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400387,,,,,,,,,,,,,,,,,,,,,,,,,,,,CACNA1G subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3263,"[""piebaldism""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3263,,,,MESH:D016116|ICD10CM:E70.39|OMIM:172800|SNOMEDCT_US_2016_03_01:6479008|NCI:C85009|UMLS_CUI:C0080024,PIEBALD TRAIT|Partial albinism (disorder),,disease_ontology,,DOID:3263,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,piebaldism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100011,"[""F253 in ABL1(Y253F)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100011,,,,,,,,,,,,,,,,,,,,,,,,,,,,F253 in ABL1(Y253F),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200319,"[""MAPK7 gene""]",,"The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400292,,,,,,,,"The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200319,,,,,,,,,,,,,,,,5598,MAPK7,BMK1|ERK5|PRKM7,,,,,,,,,,MAPK7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200125,"[""EPHA1 gene""]",,"This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400153,,,,,,,,"This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200125,,,,,,,,,,,,,,,,2041,EPHA1,EPH|EPHT|EPHT1,,,,,,,,,,EPHA1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400345,"[""Cation channel sperm-associated family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400345,,,,,,,,,,,,,,,,,,,,,,,,,,,,Cation channel sperm-associated family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5280,"[""gastric leiomyosarcoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_10534,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5280,,,,NCI:C27200|SNOMEDCT_US_2016_03_01:447785000|UMLS_CUI:C0744295,,,disease_ontology,,DOID:5280,,,,,,,,,,,,,,,,,,,gastric leiomyosarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004493,"[""gastric epithelium cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0001088|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001120,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004493,Marion,2010-02-04T05:39:24Z,,,,,BrendaTissueOBO,gastric epithelial cell line,BTO:0004493,,,,,,,,,,,,,,,,,,,gastric epithelium cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004546,"[""hypopharyngeal squamous cell carcinoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0004439|http://purl.obolibrary.org/obo/BTO_0002024,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004546,mgr,2010-02-16T11:03:49Z,,,,,BrendaTissueOBO,HSCC cell,BTO:0004546,,,,,,,,,,,,,,,,,,,hypopharyngeal squamous cell carcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100126,"[""Glycine receptor subunit alpha-1""]",,"A glycine receptor subunit alpha-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23415] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300525,,,,,,,,"A glycine receptor subunit alpha-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23415] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100126,,,,https://pharos.nih.gov/idg/targets/P23415,,,,,,,,,,,,,GLRA1,,,P23415,,,,,,,,Glycine receptor subunit alpha-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003039,"[""hypodermal seam cell""]",,"A group of hypodermal cells in worms that lie along the apical midline of the hypodermis, at the extreme left and right sides between nose and tail.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A group of hypodermal cells in worms that lie along the apical midline of the hypodermis, at the extreme left and right sides between nose and tail.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003039,,,,,,,BrendaTissueOBO,seam cell|seam hypodermal cell,BTO:0003039,,,,,,,,,,,,,,,,,,,hypodermal seam cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_381,"[""arthropathy""]",,A bone inflammation disease that is located_in joint.,false,,,http://purl.obolibrary.org/obo/DOID_3342,,,,,,,,A bone inflammation disease that is located_in joint.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:381,,,DOID:226|DOID:13960|DOID:546|DOID:13871|DOID:2318|DOID:1843|DOID:9489|DOID:1903|DOID:2317,SNOMEDCT_US_2016_03_01:202634006|ICD10CM:M12.9|UMLS_CUI:C0022408|SNOMEDCT_US_2016_03_01:371412008|NCI:C35760|SNOMEDCT_US_2016_03_01:196415003|SNOMEDCT_US_2016_03_01:202647001|SNOMEDCT_US_2016_03_01:396275006|ICD9CM:719.9|NCI:C78402|SNOMEDCT_US_2016_03_01:202061005|SNOMEDCT_US_2016_03_01:227588009|SNOMEDCT_US_2016_03_01:399269003|SNOMEDCT_US_2016_03_01:48548006|ICD9CM:716.90|SNOMEDCT_US_2016_03_01:202073005|SNOMEDCT_US_2016_03_01:203721006|ICD10CM:M19.90|MESH:D007592|SNOMEDCT_US_2016_03_01:268056006|SNOMEDCT_US_2016_03_01:267904003|SNOMEDCT_US_2016_03_01:203747002|SNOMEDCT_US_2016_03_01:202635007|SNOMEDCT_US_2016_03_01:268070006|SNOMEDCT_US_2016_03_01:202059001|SNOMEDCT_US_2016_03_01:267888004|SNOMEDCT_US_2016_03_01:201455003|SNOMEDCT_US_2016_03_01:268051001|SNOMEDCT_US_2016_03_01:8316001|SNOMEDCT_US_2016_03_01:83486002|SNOMEDCT_US_2016_03_01:156514009|SNOMEDCT_US_2016_03_01:396233005|SNOMEDCT_US_2016_03_01:156508002|SNOMEDCT_US_2016_03_01:156616003|ICD9CM:719.90|UMLS_CUI:C0157749|SNOMEDCT_US_2016_03_01:80843008|ICD10CM:M00-M02|ICD10CM:M25.9|ICD9CM:711|SNOMEDCT_US_2016_03_01:363162000|ICD9CM:716.9|SNOMEDCT_US_2016_03_01:202645009,ankylosis of ankle and foot joint|Ankylosis of joint of hand (disorder)|Joint ankylosis of the forearm (disorder)|Ankylosis of joint of ankle and/or foot (disorder)|Joint ankylosis of the hand|Joint ankylosis of the pelvic region and thigh (disorder)|Ankylosis of joint of forearm (disorder)|Joint ankylosis of the shoulder region|ankylosis of lower leg joint|Joint ankylosis of the upper arm|Joint ankylosis of the lower leg|Ankylosis of joint of shoulder region (disorder)|ankylosis of joint of shoulder region|Joint ankylosis of the ankle and/or foot (disorder)|ankylosis of joint of pelvic region and thigh|Ankylosis of joint of multiple sites (disorder)|Ankylosis of multiple joints|Joint ankylosis of the ankle and foot|ankylosis of hand joint|Joint ankylosis of the upper arm (disorder)|Infectious arthropathy|Joint ankylosis of the pelvic region and thigh|Joint ankylosis of the forearm|Ankylosis of joint of upper arm (disorder)|ankylosis of upper arm joint|ankylosis of joint of multiple sites|Joint ankylosis of the shoulder region (disorder)|Ankylosis of joint of lower leg (disorder)|Joint ankylosis of the lower leg (disorder)|ankylosis of forearm joint,,disease_ontology,,DOID:381,,,,,,,,,,,,,,,,,,,arthropathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_384,"[""Wolff-Parkinson-White syndrome""]",,"OMIM mapping confirmed by DO. [LS].
OMIM mapping confirmed by DO. [SN].",false,,,http://purl.obolibrary.org/obo/DOID_10273,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:384,,,DOID:10392,SNOMEDCT_US_2016_03_01:195057009|MESH:D014927|UMLS_CUI:C0043202|OMIM:194200|SNOMEDCT_US_2016_03_01:251115003|SNOMEDCT_US_2016_03_01:155360000|NCI:C35132|ICD10CM:I45.6|SNOMEDCT_US_2016_03_01:195061003|UMLS_CUI:C0392470|SNOMEDCT_US_2016_03_01:17869006|ICD9CM:426.7|SNOMEDCT_US_2016_03_01:266304003|SNOMEDCT_US_2016_03_01:74390002,anomalous atrioventricular excitation|Wolff-Parkinson-White pattern (finding)|Anomalous A-V excitation,,disease_ontology,,DOID:384,,,,,,,,,,,,,,,,,"OMIM mapping confirmed by DO. [LS].
OMIM mapping confirmed by DO. [SN].",,Wolff-Parkinson-White syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000230,"[""MET956 in JAK1(Kin.Dom.1)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000230,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET956 in JAK1(Kin.Dom.1),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400323,"[""Lipid kinase gene""]",,A lipid kinase is a kinase enzyme that catalyzes the phosphorylation of a lipid substrate.,false,,,http://www.drugtargetontology.org/dto/DTO_03400103,,,,,,,,A lipid kinase is a kinase enzyme that catalyzes the phosphorylation of a lipid substrate.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400323,,,,,,,,,,,,,,,,,,,,,,,,,,,,Lipid kinase gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000228,"[""MET95 in IKKA""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000228,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET95 in IKKA,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9471,"[""meningitis""]",,"A central nervous system disease that is characterized by an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells.",false,,,http://purl.obolibrary.org/obo/DOID_331,,,,,,,,"A central nervous system disease that is characterized by an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9471,,,DOID:9712,SNOMEDCT_US_2016_03_01:154983000|ICD10CM:G03.9|SNOMEDCT_US_2016_03_01:192681009|MESH:D008581|ICD9CM:322.9|UMLS_CUI:C0025289|NCI:C26828|ICD9CM:322|SNOMEDCT_US_2016_03_01:7180009|SNOMEDCT_US_2016_03_01:192678004|ICD10CM:G03,,,disease_ontology,,DOID:9471,http://purl.obolibrary.org/obo/doid#GOLD,,,,,,,,,,,,,,,,,,meningitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14717,"[""centronuclear myopathy""]",,"A myopathy characterized by abnormally located  nuclei in skeletal muscle cells. The nuclei are located in the center of the cell, instead of their normal location at the periphery.",false,,,http://purl.obolibrary.org/obo/DOID_423,,,,,,,,"A myopathy characterized by abnormally located  nuclei in skeletal muscle cells. The nuclei are located in the center of the cell, instead of their normal location at the periphery.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14717,,,,OMIM:614807|SNOMEDCT_US_2016_03_01:82077006|OMIM:310400|OMIM:615959|ORDO:69186|NCI:C84648|ORDO:595|OMIM:614408|OMIM:255200|OMIM:160150|ORDO:69189|SNOMEDCT_US_2016_03_01:193223007|ORDO:596|UMLS_CUI:C0175709|MESH:D020914,myotubular myopathy,,disease_ontology,,DOID:14717,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,Xref MGI.,,centronuclear myopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14711,"[""FG syndrome""]",,"An X-linked disease characterized by retardation, hyperactivity, hypotonia, broad thumbs, big first toes and a characteristic facial appearance including macrocephaly and has an X-linked recessive inheritance pattern.",false,,,http://purl.obolibrary.org/obo/DOID_0050735,,,,,,,,"An X-linked disease characterized by retardation, hyperactivity, hypotonia, broad thumbs, big first toes and a characteristic facial appearance including macrocephaly and has an X-linked recessive inheritance pattern.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14711,,,,OMIM:305450|MESH:C537923|OMIM:300422|OMIM:300406|UMLS_CUI:C0220769|ORDO:93932|OMIM:300321|OMIM:300581|ORDO:323|SNOMEDCT_US_2016_03_01:49984004,Keller syndrome|Opitz-Kaveggia syndrome,,disease_ontology,,DOID:14711,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,FG syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200297,"[""MAP4K5 gene""]",,"This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400287,,,,,,,,"This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200297,,,,,,,,,,,,,,,,11183,MAP4K5,,,,,,,,,,,MAP4K5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200315,"[""TMC7 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400372,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200315,,,,,,,,,,,,,,,,79905,TMC7,,,,,,,,,,,TMC7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300352,"[""Voltage-gated proton channel (vpc) family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300352,,,,,,,,,,,,,,,,,,,,,,,,,,,,Voltage-gated proton channel (vpc) family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200323,"[""OR10T2 gene""]",,"An olfactory receptor 10T2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10T2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200323,,,,,,,,,,,,,,,,128360,OR10T2,,,,,,,,,,,OR10T2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000191,"[""IKKA kinase domain""]",,Inhibitor of nuclear factor kappa-B kinase subunit alpha,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Inhibitor of nuclear factor kappa-B kinase subunit alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000191,,,,,,,,,,,,,,,,,,,200194,,,,,,,,,IKKA kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100425,"[""Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform""]",,"phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG)  with  no mutation  in a nonphosphorylated state|A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48736] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391009,,,,,,,,"phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG)  with  no mutation  in a nonphosphorylated state|A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48736] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100425,,,,https://pharos.nih.gov/idg/targets/P48736,,,,,,,,,,,,,PIK3CG,,,P48736,,,,,,,,"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200348,"[""OR13G1 gene""]",,"An olfactory receptor 13G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 13G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200348,,,,,,,,,,,,,,,,441933,OR13G1,,,,,,,,,,,OR13G1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217573,"[""NR5A1 gene""]",,"The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_00217476,,,,,,,,"The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217573,,,,,,,,,,,,,,,,2516,NR5A1,AD4BP|FTZF1|SF1,,,,,,,,,,NR5A1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200496,"[""OR1L1 gene""]",,"An olfactory receptor 1L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH94] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH94] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200496,,,,,,,,,,,,,,,,26737,OR1L1,OR1L2,,,,,,,,,,OR1L1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200066,"[""CDK1 gene""]",,"The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400258,,,,,,,,"The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200066,,,,,,,,,,,,,,,,983,CDK1,CDC2|CDC28A|CDKN1,,,,,,,,,,CDK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001912,"[""breast adenocarcinoma cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0000167|http://purl.obolibrary.org/obo/BTO_0000356|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001912,,,,,,,BrendaTissueOBO,,BTO:0001912,,,,,,,,,,,,,,,,,,,breast adenocarcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80308,"[""Substance P""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16094,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80308,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80308,,,,,Substance P,,CHEBI:80308,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000121,"[""MET136 in MARK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000121,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET136 in MARK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000729,"[""carcinoid cell""]",,A cell of a benign or malignant tumor arising especially from the mucosa of the gastrointestinal tract.,false,,,http://purl.obolibrary.org/obo/BTO_0001533|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A cell of a benign or malignant tumor arising especially from the mucosa of the gastrointestinal tract.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000729,,,,,,,BrendaTissueOBO,,BTO:0000729,,,,,,,,,,,,,,,,,,,carcinoid cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000289,"[""cytotoxic T-lymphocyte""]",,Subset of T-lymphocytes (mostly CD8+) responsible for lysing target cells and for killing virus-infected cells.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000782,,,,,,,,Subset of T-lymphocytes (mostly CD8+) responsible for lysing target cells and for killing virus-infected cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000289,,,,,,,BrendaTissueOBO,cytolytic T-cell|killer T-lymphocyte|killer T-cell|CTL|cytotoxic T-cell|cytolytic T-lymphocyte,BTO:0000289,,,,,,,,,,,,,,,,,,,cytotoxic T-lymphocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000151,"[""extensor""]",,"A muscle that, upon contraction, tends to straighten a limb. The antagonist of a flexor muscle.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001103,,,,,,,,"A muscle that, upon contraction, tends to straighten a limb. The antagonist of a flexor muscle.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000151,,,,,,,BrendaTissueOBO,,BTO:0000151,,,,,,,,,,,,,,,,,,,extensor,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200703,"[""OR8J3 gene""]",,"An olfactory receptor 8J3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 8J3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200703,,,,,,,,,,,,,,,,81168,OR8J3,,,,,,,,,,,OR8J3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_480,"[""movement disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_936,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:480,,,,NCI:C116757|UMLS_CUI:C0026650|MESH:D009069|SNOMEDCT_US_2016_03_01:60342002,,,disease_ontology,,DOID:480,,,,,,,,,,,,,,,,,,,movement disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_48,"[""male reproductive system disease""]",,A reproductive system disease that affects male reproductive organs.,false,,,http://purl.obolibrary.org/obo/DOID_15,,,,,,,,A reproductive system disease that affects male reproductive organs.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:48,,,,SNOMEDCT_US_2016_03_01:155933004|ICD9CM:608.9|ICD9CM:600-608.99|ICD10CM:N50.9|SNOMEDCT_US_2016_03_01:155905004|SNOMEDCT_US_2016_03_01:64557000|UMLS_CUI:C0017412|SNOMEDCT_US_2016_03_01:198089001|MESH:D005832|SNOMEDCT_US_2016_03_01:198553004|SNOMEDCT_US_2016_03_01:155945008,,,disease_ontology,,DOID:48,,,,,,,,,,,,,,,,,,,male reproductive system disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491020,"[""ITPK1 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400323,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491020,,,,,,,,,,,,,,,,,,,,,,,,,,,,ITPK1 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_461,"[""muscle benign neoplasm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060099,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:461,,,DOID:2692,NCI:C4063|SNOMEDCT_US_2016_03_01:189801005|SNOMEDCT_US_2016_03_01:115228006|MESH:D009379|UMLS_CUI:C0027664|SNOMEDCT_US_2016_03_01:189786009|MESH:D019042|SNOMEDCT_US_2016_03_01:126616000|SNOMEDCT_US_2016_03_01:134329004|UMLS_CUI:C0282606,neoplasm of muscle (disorder)|Myomatous tumor|muscle neoplasm|Myomatous neoplasm|muscle tissue neoplasm,,disease_ontology,,DOID:461,,,,,,,,,,,,,,,,,,,muscle benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100170,"[""Voltage-gated potassium channel subunit beta-2""]",,"A voltage-gated potassium channel subunit beta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13303] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300356,,,,,,,,"A voltage-gated potassium channel subunit beta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13303] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100170,,,,https://pharos.nih.gov/idg/targets/Q13303,,,,,,,,,,,,,KCNAB2,KCNA2B|KCNK2,,Q13303,,,,,,,,Voltage-gated potassium channel subunit beta-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050980,"[""spinocerebellar ataxia type 31""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1441,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050980,lschriml,2015-10-06T16:11:07Z,,OMIM:117210,,,disease_ontology,,DOID:0050980,,,,,,,,,,,,,,,,,,,spinocerebellar ataxia type 31,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050989,"[""episodic ataxia type 1""]",,,false,,,http://purl.obolibrary.org/obo/DOID_963,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050989,lschriml,2015-10-06T16:26:26Z,,OMIM:160120,,,disease_ontology,,DOID:0050989,,,,,,,,,,,,,,,,,,,episodic ataxia type 1,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000313,"[""hypodermis""]",,The outer cellular layer of the body of invertebrates which secretes the cuticular exoskeleton.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000634,,,,,,,,The outer cellular layer of the body of invertebrates which secretes the cuticular exoskeleton.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000313,,,,,,,BrendaTissueOBO,hypoderm,BTO:0000313,,,,,,,,,,,,,,,,,,,hypodermis,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14692,"[""Smith-Lemli-Opitz syndrome""]",,OMIM mapping confirmed by DO. [LS].,false,,,http://purl.obolibrary.org/obo/DOID_3146,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14692,,,DOID:4366,OMIM:270400|SNOMEDCT_US_2016_03_01:43929004|NCI:C85071|ICD10CM:E78.72|UMLS_CUI:C0175694|MESH:D019082,Smith-Opitz-Inborn syndrome|Rutledge lethal multiple congenital anomaly syndrome,,disease_ontology,,DOID:14692,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,Smith-Lemli-Opitz syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14693,"[""Clouston syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14693,,,,OMIM:129500|MESH:D004476|UMLS_CUI:C0162361|SNOMEDCT_US_2016_03_01:54209007,hidrotic ectodermal dysplasia|Clouston's hidrotic ectodermal dysplasia |Clouston's syndrome|Hidrotic ectodermal dysplasia syndrome (disorder),,disease_ontology,,DOID:14693,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Clouston syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14699,"[""thrombocytopenia-absent radius syndrome""]",,OMIM mapping confirmed by DO. [LS].,false,,,http://purl.obolibrary.org/obo/DOID_0060388,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14699,,,,ICD10CM:Q87.2|SNOMEDCT_US_2016_03_01:85589009|OMIM:274000|MESH:C536940|NCI:C99038|UMLS_CUI:C0175703,chromosome 1q21.1 deletion syndrome|Thrombocytopenia with absent radii (TAR) syndrome|Radial aplasia-thrombocytopenia syndrome (disorder),,disease_ontology,,DOID:14699,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,thrombocytopenia-absent radius syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003123,"[""microvascular endothelial cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001854,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003123,,,,,,,BrendaTissueOBO,MVEC cell,BTO:0003123,,,,,,,,,,,,,,,,,,,microvascular endothelial cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300525,"[""GLRA1 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300409,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300525,,,,,,,,,,,,,,,,,,,,,,,,,,,,GLRA1 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100355,"[""Olfactory receptor 14J1""]",,"An olfactory receptor 14J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UGF5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 14J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UGF5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100355,,,,https://pharos.nih.gov/idg/targets/Q9UGF5,,,,,,,,,,,,,OR14J1,OR5U1,,Q9UGF5,,,,,,,,Olfactory receptor 14J1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200596,"[""OR4K15 gene""]",,"An olfactory receptor 4K15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH41] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4K15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH41] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200596,,,,,,,,,,,,,,,,81127,OR4K15,,,,,,,,,,,OR4K15 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100224,"[""Cgmp-dependent protein kinase 1""]",,"A cGMP-dependent protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13976] |cGMP-dependent protein kinase 1 (KGP1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300173,,,,,,,,"A cGMP-dependent protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13976] |cGMP-dependent protein kinase 1 (KGP1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100224,,,,https://pharos.nih.gov/idg/targets/Q13976,,,,,,,,,,,,,PRKG1,PRKG1B|PRKGR1A|PRKGR1B,,Q13976,,,,,,,,Cgmp-dependent protein kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004470,"[""LM6 cell""]",,Hepatocellular carcinoma cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0000578|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Hepatocellular carcinoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004470,Marion,2010-02-04T10:03:31Z,,,,,BrendaTissueOBO,,BTO:0004470,,,,,,,,,,,,,,,,,,,LM6 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100064,"[""Cystic fibrosis transmembrane conductance regulator""]",,"A cystic fibrosis transmembrane conductance regulator (cftr) that is encoded in the genome of human. [PRO:CNA, UniProtKB:P13569] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300392,,,,,,,,"A cystic fibrosis transmembrane conductance regulator (cftr) that is encoded in the genome of human. [PRO:CNA, UniProtKB:P13569] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100064,,,,https://pharos.nih.gov/idg/targets/P13569,,,,,,,,,,,,,CFTR,ABCC7,,P13569,,,,,,,,Cystic fibrosis transmembrane conductance regulator,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050292,"[""primary systemic mycosis""]",,"A systemic mycosis that results_in infection located_in human body, has_material_basis_in Fungi, which can overcome the physiological and cellular defences of the normal human host. The primary deep pathogens usually gain access to the host via the respiratory tract.",false,,,http://purl.obolibrary.org/obo/DOID_0050136,,,,,,,,"A systemic mycosis that results_in infection located_in human body, has_material_basis_in Fungi, which can overcome the physiological and cellular defences of the normal human host. The primary deep pathogens usually gain access to the host via the respiratory tract.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050292,,,,,,,disease_ontology,,DOID:0050292,,,,,,,,,,,,,,,,,,,primary systemic mycosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11772,"[""leukocoria""]",,,false,,,http://purl.obolibrary.org/obo/DOID_9799,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11772,,,,SNOMEDCT_US_2016_03_01:1361009|UMLS_CUI:C0152458|ICD9CM:360.44|ICD10CM:H44.53|SNOMEDCT_US_2016_03_01:193288000,Leucocoria,,disease_ontology,,DOID:11772,,,,,,,,,,,,,,,,,,,leukocoria,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400407,"[""CNGB3 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400343,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400407,,,,,,,,,,,,,,,,,,,,,,,,,,,,CNGB3 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004585,"[""acute promyelocytic leukemia cell""]",,"A subtype of acute myelogenous leukemia (AML), a cancer of the blood and bone marrow. In APL, there is an abnormal accumulation of immature granulocytes called promyelocytes.",false,,,http://purl.obolibrary.org/obo/BTO_0001545|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A subtype of acute myelogenous leukemia (AML), a cancer of the blood and bone marrow. In APL, there is an abnormal accumulation of immature granulocytes called promyelocytes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004585,mgr,2010-04-12T10:58:54Z,,,,,BrendaTissueOBO,APL cell|acute progranulocytic leukemia cell,BTO:0004585,,,,,,,,,,,,,,,,,,,acute promyelocytic leukemia cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000137,"[""EPHA5 kinase domain""]",,EPH receptor A5; CEK7; EHK1; EPHA5; HEK7; TYRO4,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,EPH receptor A5; CEK7; EHK1; EPHA5; HEK7; TYRO4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000137,,,,,,,,,,,,,,,,,,,200139,,,,,,,,,EPHA5 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100187,"[""Potassium voltage-gated channel subfamily b member 1""]",,"A voltage-gated potassium channel KCNB1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q14721] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300539,,,,,,,,"A voltage-gated potassium channel KCNB1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q14721] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100187,,,,https://pharos.nih.gov/idg/targets/Q14721,,,,,,,,,,,,,KCNB1,,,Q14721,,,,,,,,Potassium voltage-gated channel subfamily b member 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117500,"[""Hepatocyte nuclear factor 4-gamma""]",,"A hepatocyte nuclear factor 4-gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14541] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117467,,,,,,,,"A hepatocyte nuclear factor 4-gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14541] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117500,,,,https://pharos.nih.gov/idg/targets/Q14541,,,,,,,,,,,,,HNF4G,,,Q14541,,,,,,,,Hepatocyte nuclear factor 4-gamma,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000084,"[""CDKL2 kinase domain""]",,Cyclin-dependent kinase-like 2 (CDC2-related kinase); CDKL2; KKIAMRE; P56,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Cyclin-dependent kinase-like 2 (CDC2-related kinase); CDKL2; KKIAMRE; P56,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000084,,,,,,,,,,,,,,,,,,,200084,,,,,,,,,CDKL2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000143,"[""EPHB3 kinase domain""]",,Ephrin type-B receptor 3; EPHB3; ETK2; HEK2; TYRO6,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Ephrin type-B receptor 3; EPHB3; ETK2; HEK2; TYRO6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000143,,,,,,,,,,,,,,,,,,,200145,,,,,,,,,EPHB3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11963,"[""esophagitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_6050,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11963,,,DOID:11962,SNOMEDCT_US_2016_03_01:196605000|ICD10CM:K20.9|SNOMEDCT_US_2016_03_01:155673008|MESH:D004941|SNOMEDCT_US_2016_03_01:266498005|ICD9CM:530.1|UMLS_CUI:C0014868|SNOMEDCT_US_2016_03_01:16761005|NCI:C9224|ICD10CM:K20|ICD9CM:530.10,acute esophagitis,,disease_ontology,,DOID:11963,,,,,,,,,,,,,,,,,,,esophagitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117467,"[""Hepatocyte nuclear factor-4 receptors""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00102000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117467,,,,,,,,,,,,,,,,,,,,,,,,,,,,Hepatocyte nuclear factor-4 receptors,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_369,"[""olfactory neuroblastoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_366|http://purl.obolibrary.org/obo/DOID_1352|http://purl.obolibrary.org/obo/DOID_0050615,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:369,,,,SNOMEDCT_US_2016_03_01:68614005|UMLS_CUI:C0206717|MESH:D018304|SNOMEDCT_US_2016_03_01:422886007|SNOMEDCT_US_2016_03_01:189938009|SNOMEDCT_US_2016_03_01:76060004|NCI:C3789|NCI:C6016|SNOMEDCT_US_2016_03_01:189937004,Esthesioneuroepithelioma [dup] (morphologic abnormality)|Esthesioneuroepithelioma (morphologic abnormality)|Asthesioneuroblastoma (morphologic abnormality)|paranasal sinus Olfactory neuroblastoma|Esthesioneuroblastoma (morphologic abnormality)|Olfactory Esthesioneuroblastoma,,disease_ontology,,DOID:369,,,,,,,,,,,,,,,,,,,olfactory neuroblastoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_366,"[""olfactory nerve neoplasm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2815,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:366,,,,NCI:C5121|SNOMEDCT_US_2016_03_01:126967000|UMLS_CUI:C0346319,neoplasm of olfactory nerve (disorder)|tumor of Olfactory nerve,,disease_ontology,,DOID:366,,,,,,,,,,,,,,,,,,,olfactory nerve neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_365,"[""bladder disease""]",,A urinary system disease that is located_in the bladder.,false,,,http://purl.obolibrary.org/obo/DOID_18,,,,,,,,A urinary system disease that is located_in the bladder.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:365,,,,SNOMEDCT_US_2016_03_01:42643001|MESH:D001745|SNOMEDCT_US_2016_03_01:155886002|SNOMEDCT_US_2016_03_01:266630005|ICD9CM:596.9|SNOMEDCT_US_2016_03_01:197897007|SNOMEDCT_US_2016_03_01:155890000|UMLS_CUI:C0005686|NCI:C2900|ICD10CM:N32.9,Urinary Bladder Disease,,disease_ontology,,DOID:365,,,,,,,,,,,,,,,,,,,bladder disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_363,"[""uterine cancer""]",,A female reproductive organ cancer that is located_in the uterus.,false,,,http://purl.obolibrary.org/obo/DOID_120,,,,,,,,A female reproductive organ cancer that is located_in the uterus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:363,,,DOID:4363,SNOMEDCT_US_2016_03_01:94127009|SNOMEDCT_US_2016_03_01:371973000|SNOMEDCT_US_2016_03_01:126908007|NCI:C3435|ICD10CM:C55|SNOMEDCT_US_2016_03_01:156169001|UMLS_CUI:C0042138|SNOMEDCT_US_2016_03_01:269613007|ICD9CM:179|SNOMEDCT_US_2016_03_01:188173004|UMLS_CUI:C0153567|NCI:C3552|MESH:D014594|SNOMEDCT_US_2016_03_01:93718007,malignant uterine tumor|malignant neoplasm of uterus (disorder)|CA - cancer of uterus|Tumour of uterus|uterine tumor|Ca uterus NOS|neoplasm of uterus (disorder)|uterus neoplasm,,disease_ontology,,DOID:363,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,uterine cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_368,"[""cerebrum cancer""]",,A supratentorial cancer that is located_in the cerebrum.,false,,,http://purl.obolibrary.org/obo/DOID_1659,,,,,,,,A supratentorial cancer that is located_in the cerebrum.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:368,,,DOID:912,NCI:C4874|UMLS_CUI:C0153642|UMLS_CUI:C1263885|ICD9CM:191.8|SNOMEDCT_US_2016_03_01:126953009|SNOMEDCT_US_2016_03_01:188300006|SNOMEDCT_US_2016_03_01:188304002,tumor of Cerebrum|neoplasm of cerebrum (disorder)|cerebral cancer,,disease_ontology,,DOID:368,,,,,,,,,,,,,,,,,,,cerebrum cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002312,"[""mature cell""]",,Having reached full natural growth or development: a mature cell.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002322,,,,,,,,Having reached full natural growth or development: a mature cell.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002312,,,,,,,BrendaTissueOBO,,BTO:0002312,,,,,,,,,,,,,,,,,,,mature cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000007,"[""GLN105 in ERK4""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30011,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000007,,,,,,,,,,,,,,,,,,,,,,,,,,,,GLN105 in ERK4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000209,"[""KC1G2 kinase domain""]",,"Casein kinase I isoform gamma-2; Casein kinase 1, gamma 2; CK1g2; CSNK1G2",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Casein kinase I isoform gamma-2; Casein kinase 1, gamma 2; CK1g2; CSNK1G2",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000209,,,,,,,,,,,,,,,,,,,200101,,,,,,,,,KC1G2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10314,"[""endocarditis""]",,A endocardium disease characterized by inflammation of the endocardium of the heart chambers and valves.,false,,,http://purl.obolibrary.org/obo/DOID_0050825,,,,,,,,A endocardium disease characterized by inflammation of the endocardium of the heart chambers and valves.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10314,,,DOID:14058,SNOMEDCT_US_2016_03_01:56819008|UMLS_CUI:C0014118|NCI:C34582|ICD9CM:421.9|SNOMEDCT_US_2016_03_01:91357005|ICD10CM:I33.9|NCI:C35432|MESH:D004696|UMLS_CUI:C0375268|SNOMEDCT_US_2016_03_01:194935007,,,disease_ontology,,DOID:10314,,,,,,,,,,,,,,,,,,,endocarditis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10316,"[""pneumoconiosis""]",,An interstitial lung disease that is caused by the inhalation of dust.,false,,,http://purl.obolibrary.org/obo/DOID_3082,,,,,,,,An interstitial lung disease that is caused by the inhalation of dust.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10316,,,,SNOMEDCT_US_2016_03_01:40122008|ICD10CM:J64|SNOMEDCT_US_2016_03_01:155591007|SNOMEDCT_US_2016_03_01:196004000|ICD9CM:505|SNOMEDCT_US_2016_03_01:266401007|SNOMEDCT_US_2016_03_01:155587002|UMLS_CUI:C0032273|SNOMEDCT_US_2016_03_01:196016006|MESH:D011009|NCI:C26861,,,disease_ontology,,DOID:10316,,,,,,,,,,,,,,,,,,,pneumoconiosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100035,"[""Voltage-dependent calcium channel subunit alpha-2/delta-2""]",,"A voltage-dependent calcium channel subunit alpha-2/delta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NY47] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300332,,,,,,,,"A voltage-dependent calcium channel subunit alpha-2/delta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NY47] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100035,,,,https://pharos.nih.gov/idg/targets/Q9NY47,,,,,,,,,,,,,CACNA2D2,KIAA0558,,Q9NY47,,,,,,,,Voltage-dependent calcium channel subunit alpha-2/delta-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4515,"[""thyroid sarcoma""]",,A thyroid cancer that is located_in the supporting cells of the thyroid.,false,,,http://purl.obolibrary.org/obo/DOID_1115|http://purl.obolibrary.org/obo/DOID_1781,,,,,,,,A thyroid cancer that is located_in the supporting cells of the thyroid.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4515,,,,UMLS_CUI:C1336756|NCI:C6041,sarcoma of the Thyroid gland,,disease_ontology,,DOID:4515,,,,,,,,,,,,,,,,,,,thyroid sarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000012,"[""CCL11""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000012,,,,,,,,,,,,,,,,,,,,,,,,,,,,CCL11,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100679,"[""Olfactory receptor 7c2""]",,"An olfactory receptor 7C2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60412] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 7C2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60412] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100679,,,,https://pharos.nih.gov/idg/targets/O60412,,,,,,,,,,,,,OR7C2,OR7C3,,O60412,,,,,,,,Olfactory receptor 7c2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100354,"[""Olfactory receptor 14I1""]",,"An olfactory receptor 14I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6ND48] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 14I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6ND48] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100354,,,,https://pharos.nih.gov/idg/targets/A6ND48,,,,,,,,,,,,,OR14I1,OR5BU1|OR5BU1P,,A6ND48,,,,,,,,Olfactory receptor 14I1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300515,"[""GABRD sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300515,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRD sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000364,"[""stratum lucidum""]",,A thin somewhat translucent layer of cells lying superficial to the stratum granulosum and under the stratum corneum especially in thickened parts of the epidermis.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A thin somewhat translucent layer of cells lying superficial to the stratum granulosum and under the stratum corneum especially in thickened parts of the epidermis.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000364,,,,,,,BrendaTissueOBO,,BTO:0000364,,,,,,,,,,,,,,,,,,,stratum lucidum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004137,"[""KCL-22 cell""]",,A Philadelphia chromosome-positive cell line established from peripheral blood of a patient with chronic myelogenous leukemia in blast crisis.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002580,,,,,,,,A Philadelphia chromosome-positive cell line established from peripheral blood of a patient with chronic myelogenous leukemia in blast crisis.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004137,,,,,,,BrendaTissueOBO,KCL22 cell,BTO:0004137,,,,,,,,,,,,,,,,,,,KCL-22 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200249,"[""PSKH2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400177,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200249,,,,,,,,,,,,,,,,85481,PSKH2,,,,,,,,,,,PSKH2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001272,"[""sperm flagellum""]",,"The posterior, filiform part of spermatozoa, which provides sperm motility.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The posterior, filiform part of spermatozoa, which provides sperm motility.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001272,,,,,,,BrendaTissueOBO,sperm tail,BTO:0001272,,,,,,,,,,,,,,,,,,,sperm flagellum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9181,"[""amebiasis""]",,"A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs.",false,,,http://purl.obolibrary.org/obo/DOID_2789,,,,,,,,"A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9181,,,DOID:11901|DOID:11904,SNOMEDCT_US_2016_03_01:187278004|UMLS_CUI:C0002438|SNOMEDCT_US_2016_03_01:282008000|ICD10CM:A06|SNOMEDCT_US_2016_03_01:154274000|SNOMEDCT_US_2016_03_01:105637008|MESH:D000562|ICD9CM:006|SNOMEDCT_US_2016_03_01:186122001|ICD9CM:006.9|SNOMEDCT_US_2016_03_01:111909004|SNOMEDCT_US_2016_03_01:388759003|SNOMEDCT_US_2016_03_01:111910009|SNOMEDCT_US_2016_03_01:387754006|ICD10CM:A06.9|NCI:C84551,entamoebiasis|amoebiasis,,disease_ontology,chronic intestinal amebiasis,DOID:9181,,,,,,,,,,,,,,,,,,,amebiasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100783,"[""Taste receptor type 2 member 31""]",,"A taste receptor type 2 member 44 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59538] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300014,,,,,,,,"A taste receptor type 2 member 44 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59538] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100783,,,,https://pharos.nih.gov/idg/targets/P59538,,,,,,,,,,,,,TAS2R31,TAS2R44,,P59538,,,,,,,,Taste receptor type 2 member 31,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200740,"[""F2RL3 gene""]",,"A proteinase-activated receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96RI0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002|http://www.drugtargetontology.org/dto/DTO_02400079,,,,,,,,"A proteinase-activated receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96RI0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200740,,,,,,,,,,,,,,,,9002,F2RL3,PAR4,,,,,,,,,,F2RL3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200143,"[""ERN2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400154,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200143,,,,,,,,,,,,,,,,10595,ERN2,IRE2,,,,,,,,,,ERN2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200335,"[""MAP2K2 gene""]",,"The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400194,,,,,,,,"The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200335,,,,,,,,,,,,,,,,5605,MAP2K2,MEK2|MKK2|PRKMK2,,,,,,,,,,MAP2K2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200022,"[""ALK gene""]",,"This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400122,,,,,,,,"This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200022,,,,,,,,,,,,,,,,238,ALK,,,,,,,,,,,ALK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100627,"[""Olfactory receptor 5H6""]",,"An olfactory receptor 5H6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGV6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5H6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGV6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100627,,,,https://pharos.nih.gov/idg/targets/Q8NGV6,,,,,,,,,,,,,OR5H6,,,Q8NGV6,,,,,,,,Olfactory receptor 5H6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1094,"[""attention deficit hyperactivity disorder""]",,"A specific developmental disorder that is characterized by co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone"" and symptoms starting before seven years of age.",false,,,http://purl.obolibrary.org/obo/DOID_0060038,,,,,,,,"A specific developmental disorder that is characterized by co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone"" and symptoms starting before seven years of age.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1094,,,DOID:1093,UMLS_CUI:C0154629|OMIM:608905|MESH:D001289|OMIM:608906|OMIM:608903|OMIM:613003|OMIM:608904|OMIM:612311|OMIM:612312|UMLS_CUI:C0041671|OMIM:143465|NCI:C35092|ICD9CM:314.8|EFO:0003888,hyperkinetic disorder|attention deficit disorder|ADHD,,disease_ontology,,DOID:1094,,,,,,,,,,,,,,,,,Xref MGI.,,attention deficit hyperactivity disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10944,"[""tongue disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_403,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10944,,,,ICD10CM:K14|ICD10CM:K14.9|SNOMEDCT_US_2016_03_01:266496009|SNOMEDCT_US_2016_03_01:155533008|SNOMEDCT_US_2016_03_01:155665004|SNOMEDCT_US_2016_03_01:196595001|ICD9CM:529.9|SNOMEDCT_US_2016_03_01:69244009|MESH:D014060|UMLS_CUI:C0040409|SNOMEDCT_US_2016_03_01:155667007,,,disease_ontology,,DOID:10944,,,,,,,,,,,,,,,,,,,tongue disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10941,"[""intracranial aneurysm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3527,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10941,,,,UMLS_CUI:C0007766|SNOMEDCT_US_2016_03_01:42994005|SNOMEDCT_US_2016_03_01:128609009|MESH:D002532|EFO:0003870|NCI:C34458,brain aneurysm,,disease_ontology,,DOID:10941,,,,,,,,,,,,,,,,,,,intracranial aneurysm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000012,"[""ABL1(H396P) kinase domain""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000012,,,,,,,,,,,,,,,,,,,,,,,,,,,,ABL1(H396P) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000126,"[""Large neurotensin""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000126,,,,,,,,,,,,,,,,,,,,,,,,,,,,Large neurotensin,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100548,"[""Tyrosine-protein kinase txk""]",,"tyrosine-protein kinase txk (TXK)  with  no mutation  in a nonphosphorylated state|A tyrosine-protein kinase TXK that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42681] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300133,,,,,,,,"tyrosine-protein kinase txk (TXK)  with  no mutation  in a nonphosphorylated state|A tyrosine-protein kinase TXK that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42681] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100548,,,,https://pharos.nih.gov/idg/targets/P42681,,,,,,,,,,,,,TXK,PTK4|RLK,,P42681,,,,,,,,Tyrosine-protein kinase txk,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100583,"[""Olfactory receptor 4D11""]",,"An olfactory receptor 4D11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4D11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100583,,,,https://pharos.nih.gov/idg/targets/Q8NGI4,,,,,,,,,,,,,OR4D11,OR4D11P,,Q8NGI4,,,,,,,,Olfactory receptor 4D11,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400274,"[""ILK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400165,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400274,,,,,,,,,,,,,,,,,,,,,,,,,,,,ILK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400121,"[""AKT family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400121,,,,,,,,,,,,,,,,,,,,,,,,,,,,AKT family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3952,"[""adrenal cortex disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_9553,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3952,,,,UMLS_CUI:C0001614|MESH:D000303|SNOMEDCT_US_2016_03_01:129636003,,,disease_ontology,,DOID:3952,,,,,,,,,,,,,,,,,,,adrenal cortex disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004422,"[""pleural cavity""]",,"The space enclosed by the pleura, which is a thin layer of tissue that covers the lungs and lines the interior wall of the chest cavity.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The space enclosed by the pleura, which is a thin layer of tissue that covers the lungs and lines the interior wall of the chest cavity.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004422,Marion,2010-02-01T02:05:38Z,,,,,BrendaTissueOBO,,BTO:0004422,,,,,,,,,,,,,,,,,,,pleural cavity,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300084,"[""Parathyroid hormone receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300003,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300084,,,,,,,,,,,,,,,,,,,,,,,,,,,,Parathyroid hormone receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100607,"[""Olfactory receptor 4S1""]",,"An olfactory receptor 4S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100607,,,,https://pharos.nih.gov/idg/targets/Q8NGB4,,,,,,,,,,,,,OR4S1,,,Q8NGB4,,,,,,,,Olfactory receptor 4S1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100289,"[""Olfactory receptor 10A3""]",,"An olfactory receptor 10A3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58181] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10A3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58181] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100289,,,,https://pharos.nih.gov/idg/targets/P58181,,,,,,,,,,,,,OR10A3,,,P58181,,,,,,,,Olfactory receptor 10A3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000138,"[""MET169 in ROCK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000138,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET169 in ROCK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400235,"[""TLK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400235,,,,,,,,,,,,,,,,,,,,,,,,,,,,TLK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002688,"[""vascular cell""]",,A cell of the vascular system.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A cell of the vascular system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002688,,,,,,,BrendaTissueOBO,,BTO:0002688,,,,,,,,,,,,,,,,,,,vascular cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000423,"[""STK39 kinase domain""]",,"STE20/SPS1-related proline-alanine-rich protein kinase; serine threonine kinase 39 (STE20/SPS1 homolog, yeast); DCHT; DKFZp686K05124; PASK; SPAK; STLK3",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"STE20/SPS1-related proline-alanine-rich protein kinase; serine threonine kinase 39 (STE20/SPS1 homolog, yeast); DCHT; DKFZp686K05124; PASK; SPAK; STLK3",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000423,,,,,,,,,,,,,,,,,,,200424,,,,,,,,,STK39 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000107,"[""DAPK3 kinase domain""]",,Death-associated protein kinase 3; DAPK3; FLJ36473; ZIP; ZIPK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Death-associated protein kinase 3; DAPK3; FLJ36473; ZIP; ZIPK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000107,,,,,,,,,,,,,,,,,,,200108,,,,,,,,,DAPK3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_27385,"[""tetrachloromethane""]","InChI=1S/CCl4/c2-1(3,4)5|VZGDMQKNWNREIO-UHFFFAOYSA-N|CCl4|Tetrachlormethan|Kohlenstofftetrachlorid|153.82300|Tetrachlorkohlenstoff|tetrachloridocarbon|Tetra|151.875|ClC(Cl)(Cl)Cl|Carbon tetrachloride|0",A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,Reaxys:1098295|PMID:24726765|Wikipedia:Carbon_Tetrachloride|Drug_Central:3067|LINCS:LSM-37019|Gmelin:2347|HMDB:HMDB31330|Beilstein:1098295|CAS:56-23-5|PMID:24395137|UM-BBD_compID:c0486|KEGG:C07561,A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:23015|CHEBI:3400,,Tetrachloromethane|tetrachloromethane,,chebi_ontology,"InChI=1S/CCl4/c2-1(3,4)5|VZGDMQKNWNREIO-UHFFFAOYSA-N|CCl4|Tetrachlormethan|Kohlenstofftetrachlorid|153.82300|Tetrachlorkohlenstoff|tetrachloridocarbon|Tetra|151.875|ClC(Cl)(Cl)Cl|Carbon tetrachloride|0",,,CHEBI:27385,,,,,,,,,,,,,,,,,,,,,,,CHEBI:27385,,,,,tetrachloromethane,,CHEBI:27385,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100412,"[""Olfactory receptor 52B4""]",,"An olfactory receptor 52B4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 52B4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100412,,,,https://pharos.nih.gov/idg/targets/Q8NGK2,,,,,,,,,,,,,OR52B4,,,Q8NGK2,,,,,,,,Olfactory receptor 52B4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000120,"[""EGFR kinase domain""]",,"Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000120,,,,,,,,,,,,,,,,,,,200122,,,,,,,,,EGFR kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5813,"[""purine nucleoside phosphorylase deficiency""]",,A combined T cell and B cell immunodeficiency that is a rare autosomal recessive metabolic disorder that has material basis in mutation in the PNP gene and characterized mainly by decreased T-cell function.,false,,,http://purl.obolibrary.org/obo/DOID_628,,,,,,,,A combined T cell and B cell immunodeficiency that is a rare autosomal recessive metabolic disorder that has material basis in mutation in the PNP gene and characterized mainly by decreased T-cell function.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5813,,,,SNOMEDCT_US_2016_03_01:60743005|OMIM:613179|SNOMEDCT_US_2016_03_01:191000008|NCI:C3963|MESH:C562587|UMLS_CUI:C0268125|SNOMEDCT_US_2016_03_01:124271005|ICD10CM:D81.5,PNP deficiency|Purine-Nucleoside Phosphorylase deficiency|Purine nucleoside phosphorylase deficiency|deficiency of inosine phosphorylase,,disease_ontology,,DOID:5813,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,purine nucleoside phosphorylase deficiency,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004725,"[""embryonic fibroblast""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000452,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004725,mgr,2010-08-20T08:25:19Z,,,,,BrendaTissueOBO,,BTO:0004725,,,,,,,,,,,,,,,,,,,embryonic fibroblast,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100230,"[""Small conductance calcium-activated potassium channel protein 3""]",,"A small conductance calcium-activated potassium channel protein 3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9UGI6] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300437,,,,,,,,"A small conductance calcium-activated potassium channel protein 3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9UGI6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100230,,,,https://pharos.nih.gov/idg/targets/Q9UGI6,,,,,,,,,,,,,KCNN3,K3,,Q9UGI6,,,,,,,,Small conductance calcium-activated potassium channel protein 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000005,"[""Apelin-17""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000005,,,,,,,,,,,,,,,,,,,,,,,,,,,,Apelin-17,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100251,"[""Ribosomal protein s6 kinase alpha-1""]",,"ribosomal protein s6 kinase alpha-1 (RSK1(Kin.Dom.2-C-terminal))  with  no mutation  in a nonphosphorylated state|ribosomal protein s6 kinase alpha-1 (RSK1(Kin.Dom.1-N-terminal))  with  no mutation  in a nonphosphorylated state|A ribosomal protein S6 kinase alpha-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15418] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300280,,,,,,,,"ribosomal protein s6 kinase alpha-1 (RSK1(Kin.Dom.2-C-terminal))  with  no mutation  in a nonphosphorylated state|ribosomal protein s6 kinase alpha-1 (RSK1(Kin.Dom.1-N-terminal))  with  no mutation  in a nonphosphorylated state|A ribosomal protein S6 kinase alpha-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15418] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100251,,,,https://pharos.nih.gov/idg/targets/Q15418,,,,,,,,,,,,,RPS6KA1,MAPKAPK1A|RSK1,,Q15418,,,,,,,,Ribosomal protein s6 kinase alpha-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100581,"[""Olfactory receptor 4d9""]",,"An olfactory receptor 4D9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4D9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100581,,,,https://pharos.nih.gov/idg/targets/Q8NGE8,,,,,,,,,,,,,OR4D9,,,Q8NGE8,,,,,,,,Olfactory receptor 4d9,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1459,"[""hypothyroidism""]",,A thyroid gland disease which involves an underproduction of thyroid hormone.,false,,,http://purl.obolibrary.org/obo/DOID_50,,,,,,,,A thyroid gland disease which involves an underproduction of thyroid hormone.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1459,,,DOID:11630,SNOMEDCT_US_2016_03_01:190274003|EFO:0004705|SNOMEDCT_US_2016_03_01:154660000|ICD9CM:244.9|SNOMEDCT_US_2016_03_01:237572004|ICD10CM:E03.9|SNOMEDCT_US_2016_03_01:190290003|SNOMEDCT_US_2016_03_01:267377003|MESH:D007037|UMLS_CUI:C0020676|SNOMEDCT_US_2016_03_01:40930008|NCI:C26800|SNOMEDCT_US_2016_03_01:267465007,Thyroid insufficiency|Thyroid deficiency,,disease_ontology,,DOID:1459,,,,,,,,,,,,,,,,,,,hypothyroidism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200055,"[""CCR3 gene""]",,"A C-C chemokine receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51677] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400095,,,,,,,,"A C-C chemokine receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51677] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200055,,,,,,,,,,,,,,,,1232,CCR3,CMKBR3,,,,,,,,,,CCR3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000291,"[""corpus allatum""]",,One of a pair of separate or fused bodies in many insects that are sometimes closely associated with the corpora cardiaca and that secrete hormones (as juvenile hormone).,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001803,,,,,,,,One of a pair of separate or fused bodies in many insects that are sometimes closely associated with the corpora cardiaca and that secrete hormones (as juvenile hormone).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000291,,,,,,,BrendaTissueOBO,corpora allata,BTO:0000291,,,,,,,,,,,,,,,,,,,corpus allatum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100367,"[""Nuclear receptor-binding protein 2""]",,"A nuclear receptor-binding protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NSY0] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300198,,,,,,,,"A nuclear receptor-binding protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NSY0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100367,,,,https://pharos.nih.gov/idg/targets/Q9NSY0,,,,,,,,,,,,,NRBP2,,,Q9NSY0,,,,,,,,Nuclear receptor-binding protein 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000779,"[""mesenteric artery""]",,"Either of two arteries arising from the aorta and passing between the two layers of the mesentery to the intestine. 1. One that arises just above the bifurcation of the abdominal aorta into the common iliac arteries and supplies the left half of the transverse colon, the descending colon, the sigmoid colon, and most of the rectum - called also inferior mesenteric artery. 2. A large artery that arises from the aorta just below the celiac artery at the level of the first lumbar vertebra and supplies the greater part of the small intestine, the cecum, the ascending colon, and the right half of the transverse colon - called also superior mesenteric artery.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000573,,,,,,,,"Either of two arteries arising from the aorta and passing between the two layers of the mesentery to the intestine. 1. One that arises just above the bifurcation of the abdominal aorta into the common iliac arteries and supplies the left half of the transverse colon, the descending colon, the sigmoid colon, and most of the rectum - called also inferior mesenteric artery. 2. A large artery that arises from the aorta just below the celiac artery at the level of the first lumbar vertebra and supplies the greater part of the small intestine, the cecum, the ascending colon, and the right half of the transverse colon - called also superior mesenteric artery.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000779,,,,,,,BrendaTissueOBO,,BTO:0000779,,,,,,,,,,,,,,,,,,,mesenteric artery,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001363,"[""testis""]",,A typically paired male reproductive gland that produces sperm and that in most mammals is contained within the scrotum at sexual maturity.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062|http://purl.obolibrary.org/obo/BTO_0003096|http://purl.obolibrary.org/obo/BTO_0000534,,,,,,,,A typically paired male reproductive gland that produces sperm and that in most mammals is contained within the scrotum at sexual maturity.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001363,,,,,,,BrendaTissueOBO,testicle|testiculus|male gonad|orchis,BTO:0001363,,,,,,,,,,,,,,,,,,,testis,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200608,"[""OR4S2 gene""]",,"An olfactory receptor 4S2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH73] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4S2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH73] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200608,,,,,,,,,,,,,,,,219431,OR4S2,OR4S2P,,,,,,,,,,OR4S2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001067,"[""pineal gland""]",,"A small, cone-shaped organ in the brain of most vertebrates that secretes the hormone melatonin.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001488,,,,,,,,"A small, cone-shaped organ in the brain of most vertebrates that secretes the hormone melatonin.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001067,,,,,,,BrendaTissueOBO,pineal organ|pineal body|epiphysis cerebri,BTO:0001067,,,,,,,,,,,,,,,,,,,pineal gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100125,"[""Ephrin type-a receptor 1""]",,"An ephrin type-A receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P21709] |ephrin type-a receptor 1 (EPHA1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300153,,,,,,,,"An ephrin type-A receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P21709] |ephrin type-a receptor 1 (EPHA1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100125,,,,https://pharos.nih.gov/idg/targets/P21709,,,,,,,,,,,,,EPHA1,EPH|EPHT|EPHT1,,P21709,,,,,,,,Ephrin type-a receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200412,"[""PI4KA gene""]",,"This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. [provided by RefSeq, Sep 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03491003,,,,,,,,"This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. [provided by RefSeq, Sep 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200412,,,,,,,,,,,,,,,,5297,PI4KA,PIK4|PIK4CA,,,,,,,,,,PI4KA gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000765,"[""exocrine gland""]",,"An externally secreting gland, such as a salivary gland or sweat gland that releases its secretions directly or through a duct.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000522,,,,,,,,"An externally secreting gland, such as a salivary gland or sweat gland that releases its secretions directly or through a duct.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000765,,,,,,,BrendaTissueOBO,,BTO:0000765,,,,,,,,,,,,,,,,,,,exocrine gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400432,"[""KCNJ5 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400432,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ5 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3540,"[""choroid plexus cancer""]",,A cerebral ventricle cancer that is located_in the plexus located_in the ventricles of the brain.,false,,,http://purl.obolibrary.org/obo/DOID_3541,,,,,,,,A cerebral ventricle cancer that is located_in the plexus located_in the ventricles of the brain.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3540,,,,SNOMEDCT_US_2016_03_01:254942002|NCI:C3473|UMLS_CUI:C0085138|MESH:D016545,tumor of the Choroid Plexus|tumor of choroid plexus (disorder),,disease_ontology,choroid plexus neoplasm,DOID:3540,,,,,,,,,,,,,,,,,,,choroid plexus cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001811,"[""seminiferous epithelium""]",,Specialised epithelium lining the seminiferous tubules containing developing and mature spermatozoa and sertoli cells.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000416,,,,,,,,Specialised epithelium lining the seminiferous tubules containing developing and mature spermatozoa and sertoli cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001811,,,,,,,BrendaTissueOBO,,BTO:0001811,,,,,,,,,,,,,,,,,,,seminiferous epithelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11801,"[""protein-energy malnutrition""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5113,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11801,,,,NCI:C34952|ICD10CM:E46|UMLS_CUI:C0033677|ICD9CM:263.9|SNOMEDCT_US_2016_03_01:267411007|SNOMEDCT_US_2016_03_01:190608007|SNOMEDCT_US_2016_03_01:238107002|SNOMEDCT_US_2016_03_01:72608005|MESH:D011502,,,disease_ontology,,DOID:11801,,,,,,,,,,,,,,,,,,,protein-energy malnutrition,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002282,"[""Pt-K2 cell""]",,Potorous tridactylis (potoroo) normal kidney cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000067,,,,,,,,Potorous tridactylis (potoroo) normal kidney cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002282,,,,,,,BrendaTissueOBO,PtK2 cell|Pt K2 cell|NBL-5 cell,BTO:0002282,,,,,,,,,,,,,,,,,,,Pt-K2 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100101,"[""Deoxycytidine kinase""]",,"A deoxycytidine kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P27707] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391008,,,,,,,,"A deoxycytidine kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P27707] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100101,,,,https://pharos.nih.gov/idg/targets/P27707,,,,,,,,,,,,,DCK,,,P27707,,,,,,,,Deoxycytidine kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2007,"[""degeneration of macula and posterior pole""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4448,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2007,,,,SNOMEDCT_US_2016_03_01:193384000|SNOMEDCT_US_2016_03_01:193392009|ICD10CM:H35.3|UMLS_CUI:C0339436|ICD9CM:362.5|SNOMEDCT_US_2016_03_01:267611002,degeneration of macula and posterior pole of retina|degeneration of macula or posterior pole,,disease_ontology,,DOID:2007,,,,,,,,,,,,,,,,,,,degeneration of macula and posterior pole,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300292,"[""ERK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300191,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300292,,,,,,,,,,,,,,,,,,,,,,,,,,,,ERK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400219,"[""ROR family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400219,,,,,,,,,,,,,,,,,,,,,,,,,,,,ROR family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217477,"[""Germ cell nuclear factor receptors gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00200002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217477,,,,,,,,,,,,,,,,,,,,,,,,,,,,Germ cell nuclear factor receptors gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005250,"[""CNE-2 cell""]",,Human nasopharyngeal carcinoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003960,,,,,,,,Human nasopharyngeal carcinoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005250,XPMUser,2011-10-01T10:36:48Z,,,,,BrendaTissueOBO,CNE2 cell,BTO:0005250,,,,,,,,,,,,,,,,,,,CNE-2 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100736,"[""Pituitary adenylate cyclase-activating polypeptide type I receptor""]",,"A pituitary adenylate cyclase-activating polypeptide type I receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41586] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300003,,,,,,,,"A pituitary adenylate cyclase-activating polypeptide type I receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41586] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100736,,,,https://pharos.nih.gov/idg/targets/P41586,,,,,,,,,,,,,ADCYAP1R1,,,P41586,,,,,,,,Pituitary adenylate cyclase-activating polypeptide type I receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14566,"[""disease of cellular proliferation""]",,A disease that is characterized by abnormally rapid cell division.,false,,,http://purl.obolibrary.org/obo/DOID_4,,,,,,,,A disease that is characterized by abnormally rapid cell division.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14566,,,DOID:0000818,,neoplasm|cell process disease,,disease_ontology,,DOID:14566,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,disease of cellular proliferation,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300553,"[""Kv10.1/KCNH1 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300448,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300553,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv10.1/KCNH1 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200268,"[""MTNR1B gene""]",,"A melatonin receptor type 1B that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49286] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400065,,,,,,,,"A melatonin receptor type 1B that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49286] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200268,,,,,,,,,,,,,,,,4544,MTNR1B,,,,,,,,,,,MTNR1B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100143,"[""Glutamate receptor ionotropic, kainate 5""]",,"A glutamate receptor ionotropic, kainate 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16478] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300420,,,,,,,,"A glutamate receptor ionotropic, kainate 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16478] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100143,,,,https://pharos.nih.gov/idg/targets/Q16478,,,,,,,,,,,,,GRIK5,GRIK2,,Q16478,,,,,,,,"Glutamate receptor ionotropic, kainate 5",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400390,"[""CACNA1S subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400333,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400390,,,,,,,,,,,,,,,,,,,,,,,,,,,,CACNA1S subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200557,"[""ULK3 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400228,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200557,,,,,,,,,,,,,,,,25989,ULK3,,,,,,,,,,,ULK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100228,"[""Hydroxycarboxylic acid receptor 2""]",,"A hydroxycarboxylic acid receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDS4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300060,,,,,,,,"A hydroxycarboxylic acid receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDS4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100228,,,,https://pharos.nih.gov/idg/targets/Q8TDS4,,,,,,,,,,,,,HCAR2,GPR109A|HCA2|HM74A|NIACR1,,Q8TDS4,,,,,,,,Hydroxycarboxylic acid receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300581,"[""TRPC6 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300482,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300581,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPC6 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02402001,"[""5-HT1 receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400017,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02402001,,,,,,,,,,,,,,,,,,,,,,,,,,,,5-HT1 receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003745,"[""liposarcoma cell""]",,"A malignant tumor that arises in fat cells in deep soft tissue, such as that inside the thigh. Most frequent in middle-aged and older adults (age 40 and above), liposarcomas are the most common of all soft-tissue sarcomas.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001207,,,,,,,,"A malignant tumor that arises in fat cells in deep soft tissue, such as that inside the thigh. Most frequent in middle-aged and older adults (age 40 and above), liposarcomas are the most common of all soft-tissue sarcomas.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003745,,,,,,,BrendaTissueOBO,,BTO:0003745,,,,,,,,,,,,,,,,,,,liposarcoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200119,"[""GABRG2 gene""]",,"This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400518,,,,,,,,"This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200119,,,,,,,,,,,,,,,,2566,GABRG2,,,,,,,,,,,GABRG2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100136,"[""Glucose-dependent insulinotropic receptor""]",,"A glucose-dependent insulinotropic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDV5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A glucose-dependent insulinotropic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDV5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100136,,,,https://pharos.nih.gov/idg/targets/Q8TDV5,,,,,,,,,,,,,GPR119,,,Q8TDV5,,,,,,,,Glucose-dependent insulinotropic receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11400,"[""pyelonephritis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2744,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11400,,,,MESH:D011704|ICD9CM:590.80|SNOMEDCT_US_2016_03_01:197779009|ICD10CM:N10-N16|UMLS_CUI:C0034186|SNOMEDCT_US_2016_03_01:45816000|ICD10CM:N16|NCI:C34965|SNOMEDCT_US_2016_03_01:197784003|ICD10CM:N12,,,disease_ontology,,DOID:11400,,,,,,,,,,,,,,,,,,,pyelonephritis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300218,"[""Other-UNIQUE family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300218,,,,,,,,,,,,,,,,,,,,,,,,,,,,Other-UNIQUE family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200224,"[""PRKG1 gene""]",,"Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400173,,,,,,,,"Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200224,,,,,,,,,,,,,,,,5592,PRKG1,PRKG1B|PRKGR1A|PRKGR1B,,,,,,,,,,PRKG1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100790,"[""Taste receptor type 2 member 46""]",,"A taste receptor type 2 member 46 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59540] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300014,,,,,,,,"A taste receptor type 2 member 46 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59540] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100790,,,,https://pharos.nih.gov/idg/targets/P59540,,,,,,,,,,,,,TAS2R46,,,P59540,,,,,,,,Taste receptor type 2 member 46,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80297,"[""Urocortin III""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16082,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80297,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80297,,,,,Urocortin III,,CHEBI:80297,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005364,"[""D-54MG cell""]",,Human glioma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000711,,,,,,,,Human glioma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005364,XPMUser,2012-08-31T10:23:54Z,,,,,BrendaTissueOBO,D54MG cell|D-54 MG cell,BTO:0005364,,,,,,,,,,,,,,,,,,,D-54MG cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001580,"[""ejaculatory duct""]",,"Either of the paired ducts in the human male that are formed by the junction of the duct from the seminal vesicle with the vas deferens, pass through the prostate, and open into or close to the prostatic utricle.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003096,,,,,,,,"Either of the paired ducts in the human male that are formed by the junction of the duct from the seminal vesicle with the vas deferens, pass through the prostate, and open into or close to the prostatic utricle.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001580,,,,,,,BrendaTissueOBO,ductus ejaculatorius,BTO:0001580,,,,,,,,,,,,,,,,,,,ejaculatory duct,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001591,"[""PA-1 cell""]",,Human ovary ascites teratocarcinoma cell line. The line was established from cells taken from ascitic fluid.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000811,,,,,,,,Human ovary ascites teratocarcinoma cell line. The line was established from cells taken from ascitic fluid.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001591,,,,,,,BrendaTissueOBO,,BTO:0001591,,,,,,,,,,,,,,,,,,,PA-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8659,"[""chickenpox""]",,"A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human herpesvirus 3, which is transmitted_by direct contact with secretions from the rash, or transmitted_by droplet spread of respiratory secretions. The infection has_symptom anorexia, has_symptom myalgia, has_symptom nausea, has_symptom fever, has_symptom headache, has_symptom sore throat, and has_symptom blisters.",false,,,http://purl.obolibrary.org/obo/DOID_37|http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human herpesvirus 3, which is transmitted_by direct contact with secretions from the rash, or transmitted_by droplet spread of respiratory secretions. The infection has_symptom anorexia, has_symptom myalgia, has_symptom nausea, has_symptom fever, has_symptom headache, has_symptom sore throat, and has_symptom blisters.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8659,,,DOID:8658|DOID:9243|DOID:8693,ICD9CM:052|SNOMEDCT_US_2016_03_01:186508005|SNOMEDCT_US_2016_03_01:154325003|ICD10CM:B01|MESH:D002644|NCI:C97132|ICD10CM:B01.9|SNOMEDCT_US_2016_03_01:38907003|UMLS_CUI:C0008049,varicella,,disease_ontology,,DOID:8659,,,,,,,,,,,,,,,,,,,chickenpox,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000288,"[""MP2K3 kinase domain""]",,Dual specificity mitogen-activated protein kinase kinase 3; mitogen-activated protein kinase kinase 3; MAP2K3; MAPKK3; MEK3; MKK3; MKK3/MAP2K3; PRKMK3,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Dual specificity mitogen-activated protein kinase kinase 3; mitogen-activated protein kinase kinase 3; MAP2K3; MAPKK3; MEK3; MKK3; MKK3/MAP2K3; PRKMK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000288,,,,,,,,,,,,,,,,,,,200253,,,,,,,,,MP2K3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000497,"[""ganglion""]",,"A group of nerve cell bodies located outside the central nervous system. The term is occasionally applied to certain nuclear groups within the brain or spinal cord, such as the basal ganglia.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A group of nerve cell bodies located outside the central nervous system. The term is occasionally applied to certain nuclear groups within the brain or spinal cord, such as the basal ganglia.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000497,,,,,,,BrendaTissueOBO,neural ganglion,BTO:0000497,,,,,,,,,,,,,,,,,,,ganglion,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000932,"[""neuroblastoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000932,,,,,,,BrendaTissueOBO,NBL cell line,BTO:0000932,,,,,,,,,,,,,,,,,,,neuroblastoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003681,"[""hairy cell leukemia cell line""]",,"A form of chronic leukemia marked by splenomegaly and the large, mononuclear, villus-covered cells called hairy cells in the bone marrow, spleen, liver, and peripheral blood.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000737,,,,,,,,"A form of chronic leukemia marked by splenomegaly and the large, mononuclear, villus-covered cells called hairy cells in the bone marrow, spleen, liver, and peripheral blood.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003681,,,,,,,BrendaTissueOBO,,BTO:0003681,,,,,,,,,,,,,,,,,,,hairy cell leukemia cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100477,"[""Serine/threonine-protein kinase sik3""]",,"serine/threonine-protein kinase sik3 (SIK3)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase QSK that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y2K2] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300314,,,,,,,,"serine/threonine-protein kinase sik3 (SIK3)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase QSK that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y2K2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100477,,,,https://pharos.nih.gov/idg/targets/Q9Y2K2,,,,,,,,,,,,,SIK3,KIAA0999|QSK,,Q9Y2K2,,,,,,,,Serine/threonine-protein kinase sik3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100771,"[""Somatostatin receptor type 2""]",,"A somatostatin receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30874] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A somatostatin receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30874] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100771,,,,https://pharos.nih.gov/idg/targets/P30874,,,,,,,,,,,,,SSTR2,,,P30874,,,,,,,,Somatostatin receptor type 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100105,"[""Frizzled-3""]",,"A frizzled-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NPG1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300043,,,,,,,,"A frizzled-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NPG1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100105,,,,https://pharos.nih.gov/idg/targets/Q9NPG1,,,,,,,,,,,,,FZD3,,,Q9NPG1,,,,,,,,Frizzled-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100423,"[""Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform""]",,"phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB)  with  no mutation  in a nonphosphorylated state|A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42338] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391009,,,,,,,,"phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB)  with  no mutation  in a nonphosphorylated state|A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42338] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100423,,,,https://pharos.nih.gov/idg/targets/P42338,,,,,,,,,,,,,PIK3CB,PIK3C1,,P42338,,,,,,,,"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100604,"[""Ketosamine-3-kinase""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100604,,,,,,,,,,,,,,,,,FN3KRP,,,Q9HA64,,,,,,,,Ketosamine-3-kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100456,"[""Olfactory receptor 5H15""]",,"An olfactory receptor 5H15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NDH6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5H15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NDH6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100456,,,,https://pharos.nih.gov/idg/targets/A6NDH6,,,,,,,,,,,,,OR5H15,,,A6NDH6,,,,,,,,Olfactory receptor 5H15,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200211,"[""CSNK1G1 gene""]",,"This gene encodes a member of the casein kinase I gene family. The encoded protein is a serine/threonine kinase that phosphorylates acidic proteins, and participates in pathways for cell growth. [provided by RefSeq, Nov 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400170,,,,,,,,"This gene encodes a member of the casein kinase I gene family. The encoded protein is a serine/threonine kinase that phosphorylates acidic proteins, and participates in pathways for cell growth. [provided by RefSeq, Nov 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200211,,,,,,,,,,,,,,,,53944,CSNK1G1,,,,,,,,,,,CSNK1G1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001060,"[""photoreceptor""]",,"A specialized cell type in a multicellular organism that is sensitive to light. This definition excludes single-celled organisms, but includes non-eye receptors, such as snake infra-red detectors or photosensitive pineal gland cells.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A specialized cell type in a multicellular organism that is sensitive to light. This definition excludes single-celled organisms, but includes non-eye receptors, such as snake infra-red detectors or photosensitive pineal gland cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001060,,,,,,,BrendaTissueOBO,photoreceptor cell,BTO:0001060,,,,,,,,,,,,,,,,,,,photoreceptor,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100503,"[""Serine/threonine-protein kinase 36""]",,"A serine/threonine-protein kinase 36 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NRP7] |serine/threonine-protein kinase 36 (STK36)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300228,,,,,,,,"A serine/threonine-protein kinase 36 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NRP7] |serine/threonine-protein kinase 36 (STK36)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100503,,,,https://pharos.nih.gov/idg/targets/Q9NRP7,,,,,,,,,,,,,STK36,KIAA1278,,Q9NRP7,,,,,,,,Serine/threonine-protein kinase 36,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200271,"[""LMTK3 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400183,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200271,,,,,,,,,,,,,,,,114783,LMTK3,KIAA1883|TYKLM3,,,,,,,,,,LMTK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001964,"[""aorta smooth muscle cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001963,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001964,,,,,,,BrendaTissueOBO,,BTO:0001964,,,,,,,,,,,,,,,,,,,aorta smooth muscle cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000851,"[""adrenal cortex cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000851,,,,,,,BrendaTissueOBO,,BTO:0000851,,,,,,,,,,,,,,,,,,,adrenal cortex cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000657,"[""jejunum""]",,"The section of the small intestine that comprises the first two fifths beyond the duodenum and that is larger, thicker-walled, and more vascular and has more circular folds than the ileum.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The section of the small intestine that comprises the first two fifths beyond the duodenum and that is larger, thicker-walled, and more vascular and has more circular folds than the ileum.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000657,,,,,,,BrendaTissueOBO,intestinum jejunum|middle intestine|mid intestine,BTO:0000657,,,,,,,,,,,,,,,,,,,jejunum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200767,"[""S1PR5 gene""]",,"A sphingosine 1-phosphate receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H228] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A sphingosine 1-phosphate receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H228] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200767,,,,,,,,,,,,,,,,53637,S1PR5,EDG8,,,,,,,,,,S1PR5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100168,"[""Retinal guanylyl cyclase 2""]",,"A retinal guanylyl cyclase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51841] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300125,,,,,,,,"A retinal guanylyl cyclase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51841] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100168,,,,https://pharos.nih.gov/idg/targets/P51841,,,,,,,,,,,,,GUCY2F,GUC2F|RETGC2,,P51841,,,,,,,,Retinal guanylyl cyclase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100082,"[""Chloride intracellular channel protein 4""]",,"A chloride intracellular channel protein 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y696] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300342,,,,,,,,"A chloride intracellular channel protein 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y696] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100082,,,,https://pharos.nih.gov/idg/targets/Q9Y696,,,,,,,,,,,,,CLIC4,,,Q9Y696,,,,,,,,Chloride intracellular channel protein 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060495,"[""shellfish allergy""]",,A food allergy triggered by Crustacea or Mollusca.,false,,,http://purl.obolibrary.org/obo/DOID_3044,,,,,,,,A food allergy triggered by Crustacea or Mollusca.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060495,,,,,,,,,DOID:0060495,,,,,,,,,,,,,,,,,,,shellfish allergy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060319,"[""cardiac arrest""]",,A congestive heart failure characterized by a sudden stop in effective blood circulation due to the failure of the heart to contract effectively or at all.,false,,,http://purl.obolibrary.org/obo/DOID_6000,,,,,,,,A congestive heart failure characterized by a sudden stop in effective blood circulation due to the failure of the heart to contract effectively or at all.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060319,emitraka,2015-02-25T15:12:30Z,,MESH:D006323|SNOMEDCT_US_2016_03_01:410430005|SNOMEDCT_US_2016_03_01:397829000|SNOMEDCT_US_2016_03_01:233926006|SNOMEDCT_US_2016_03_01:397912004|SNOMEDCT_US_2016_03_01:195090009|SNOMEDCT_US_2016_03_01:30298009|SNOMEDCT_US_2016_03_01:155372006|ICD9CM:427.5|ICD10CM:I46|NCI:C50483|UMLS_CUI:C0018790|SNOMEDCT_US_2016_03_01:195085006|SNOMEDCT_US_2016_03_01:309810002|SNOMEDCT_US_2016_03_01:410429000|UMLS_CUI:C0600228|NCI:C50479|SNOMEDCT_US_2016_03_01:251189000,cardiopulmonary arrest|circulatory arrest,,disease_ontology,,DOID:0060319,,,,,,,,,,,,,,,,,,,cardiac arrest,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060313,"[""tracheomalacia""]",,A tracheal disease characterized by flaccidity of the tracheal support cartilage.,false,,,http://purl.obolibrary.org/obo/DOID_3225,,,,,,,,A tracheal disease characterized by flaccidity of the tracheal support cartilage.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060313,emitraka,2015-02-20T16:02:03Z,,HP:0002779|SNOMEDCT_US_2016_03_01:95467005|UMLS_CUI:C0392109|ORDO:95430|ICD10CM:Q32.0|MESH:C557675,congenital tracheomalacia,,disease_ontology,,DOID:0060313,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,PRISM.,,tracheomalacia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060318,"[""acute promyelocytic leukemia""]",,An acute myeloid leukemia characterized by accumulation of promyelocytes in the bone marrow and by a translocation between chromosomes 15 and 17.,false,,,http://purl.obolibrary.org/obo/DOID_9119,,,,,,,,An acute myeloid leukemia characterized by accumulation of promyelocytes in the bone marrow and by a translocation between chromosomes 15 and 17.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060318,emitraka,2015-02-24T16:50:50Z,,SNOMEDCT_US_2016_03_01:28950004|NCI:C3182|ICD10CM:C92.4|ORDO:520|SNOMEDCT_US_2016_03_01:110004001|OMIM:612376|UMLS_CUI:C0023487|MESH:D015473|ICD10CM:C92.40,acute myeloid leukemia M3|acute myeloblastic leukemia type 3|APL,,disease_ontology,,DOID:0060318,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,acute promyelocytic leukemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060314,"[""persistent generalized lymphadenopathy""]",,"A lymph node disease characterized by enlarged, non-painful lymph nodes occurring for more than three to six months for which no other reason can be found.",false,,,http://purl.obolibrary.org/obo/DOID_9942,,,,,,,,"A lymph node disease characterized by enlarged, non-painful lymph nodes occurring for more than three to six months for which no other reason can be found.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060314,emitraka,2015-02-23T14:33:26Z,,HP:0008940,PGL,,disease_ontology,,DOID:0060314,,,,,,,,,,,,,,,,,PRISM.,,persistent generalized lymphadenopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050268,"[""ophthalmomyiasis""]",,"A myiasis that involves parasitic infestation of Oestrus ovis larvae in the eye causing severe irritation, edema, and pain.",false,,,http://purl.obolibrary.org/obo/DOID_11080,,,,,,,,"A myiasis that involves parasitic infestation of Oestrus ovis larvae in the eye causing severe irritation, edema, and pain.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050268,,,,,,,disease_ontology,,DOID:0050268,,,,,,,,,,,,,,,,,,,ophthalmomyiasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_05390001,"[""Putative infectious disease target""]",,,false,,,http://purl.obolibrary.org/obo/PR_000000001,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_05390001,,,,,,,,,,,,,,,,,,,,,,,,,,,,Putative infectious disease target,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200465,"[""OPN3 gene""]",,"An encephalopsin that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H1Y3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"An encephalopsin that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H1Y3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200465,,,,,,,,,,,,,,,,23596,OPN3,ECPN,,,,,,,,,,OPN3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100059,"[""C-c chemokine receptor type 7""]",,"A C-C chemokine receptor type 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32248] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300095,,,,,,,,"A C-C chemokine receptor type 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32248] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100059,,,,https://pharos.nih.gov/idg/targets/P32248,,,,,,,,,,,,,CCR7,CMKBR7|EBI1|EVI1,,P32248,,,,,,,,C-c chemokine receptor type 7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200188,"[""ITPKB gene""]",,"The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03491019,,,,,,,,"The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200188,,,,,,,,,,,,,,,,3707,ITPKB,,,,,,,,,,,ITPKB gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400555,"[""Kv12.2/KCNH3 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400448,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400555,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv12.2/KCNH3 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001832,"[""sympathetic nervous system""]",,"One of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord, and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera, and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter.",false,,,http://purl.obolibrary.org/obo/BTO_0001028|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"One of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord, and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera, and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001832,,,,,,,BrendaTissueOBO,sympathetic part of autonomic division of nervous system,BTO:0001832,,,,,,,,,,,,,,,,,,,sympathetic nervous system,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300134,"[""BUB family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300134,,,,,,,,,,,,,,,,,,,,,,,,,,,,BUB family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200181,"[""GPR19 gene""]",,"A G-protein coupled receptor 19 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15760] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 19 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15760] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200181,,,,,,,,,,,,,,,,2842,GPR19,,,,,,,,,,,GPR19 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391013,"[""Phosphoglycerate kinase family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300324,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391013,,,,,,,,,,,,,,,,,,,,,,,,,,,,Phosphoglycerate kinase family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004176,"[""MOLM-16 cell""]",,Human acute myeloid leukemia cell line; established in 1999 from the peripheral blood of a 77-year-old Japanese woman at relapse of acute myeloid leukemia (AML M0) after failed chemotherapy.,false,,,http://purl.obolibrary.org/obo/BTO_0001883|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human acute myeloid leukemia cell line; established in 1999 from the peripheral blood of a 77-year-old Japanese woman at relapse of acute myeloid leukemia (AML M0) after failed chemotherapy.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004176,,,,,,,BrendaTissueOBO,MOLM16 cell,BTO:0004176,,,,,,,,,,,,,,,,,,,MOLM-16 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200125,"[""GABRQ gene""]",,"The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes the theta subunit of the GABA A receptor. The gene is mapped to chromosome Xq28 in a cluster of genes including those that encode the alpha 3 and epsilon subunits of the GABA A receptor. This gene location is also the candidate region of two different neurologic diseases: early-onset parkinsonism (Waisman syndrome) and X-linked mental retardation (MRX3). [provided by RefSeq, Nov 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400524,,,,,,,,"The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes the theta subunit of the GABA A receptor. The gene is mapped to chromosome Xq28 in a cluster of genes including those that encode the alpha 3 and epsilon subunits of the GABA A receptor. This gene location is also the candidate region of two different neurologic diseases: early-onset parkinsonism (Waisman syndrome) and X-linked mental retardation (MRX3). [provided by RefSeq, Nov 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200125,,,,,,,,,,,,,,,,55879,GABRQ,,,,,,,,,,,GABRQ gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1470,"[""major depressive disorder""]",,"An endogenous depression that is characterized by an all-encompassing low mood accompanied by low self-esteem, and by loss of interest or pleasure in normally enjoyable activities.",false,,,http://purl.obolibrary.org/obo/DOID_1596,,,,,,,,"An endogenous depression that is characterized by an all-encompassing low mood accompanied by low self-esteem, and by loss of interest or pleasure in normally enjoyable activities.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1470,,,DOID:10614|DOID:7580|DOID:2241|DOID:2240,MESH:D003865|UMLS_CUI:C0154409|NCI:C34796|ICD9CM:296.20|SNOMEDCT_US_2016_03_01:191599006|OMIM:608691|SNOMEDCT_US_2016_03_01:192366006|SNOMEDCT_US_2016_03_01:191600009|SNOMEDCT_US_2016_03_01:66344007|SNOMEDCT_US_2016_03_01:191609005|SNOMEDCT_US_2016_03_01:36923009|ICD9CM:296.30|SNOMEDCT_US_2016_03_01:268621008|ICD10CM:F33|ICD10CM:F32.9|ICD9CM:296.3|ICD10CM:F32|SNOMEDCT_US_2016_03_01:191617002|UMLS_CUI:C0024517|SNOMEDCT_US_2016_03_01:191607007|OMIM:608520|ICD9CM:296.2|SNOMEDCT_US_2016_03_01:268620009|ICD10CM:F33.9|SNOMEDCT_US_2016_03_01:191608002,recurrent major depression|single major depressive episode,,disease_ontology,,DOID:1470,,,,,,,,,,,,,,,,,Xref MGI.,,major depressive disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14705,"[""Pfeiffer syndrome""]",,An acrocephalosyndactylia that has_material_basis_in mutations in the FGFR1 and FGFR2 gene which results_in premature fusion located_in skull.,false,,,http://purl.obolibrary.org/obo/DOID_12960,,,,,,,,An acrocephalosyndactylia that has_material_basis_in mutations in the FGFR1 and FGFR2 gene which results_in premature fusion located_in skull.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14705,,,,MESH:D000168|OMIM:101600|SNOMEDCT_US_2016_03_01:70410008|UMLS_CUI:C0220658|NCI:C99100,acrocephalosyndactylia type V,,disease_ontology,,DOID:14705,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Pfeiffer syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200098,"[""FPR1 gene""]",,"An fMet-Leu-Phe receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21462] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400041,,,,,,,,"An fMet-Leu-Phe receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21462] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200098,,,,,,,,,,,,,,,,2357,FPR1,,,,,,,,,,,FPR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004170,"[""MHCC97-L cell""]",,Clone of MHCC97 with low metastatic potential.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Clone of MHCC97 with low metastatic potential.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004170,,,,,,,BrendaTissueOBO,MHCC 97-L cell|MHCC97Lcell,BTO:0004170,,,,,,,,,,,,,,,,,,,MHCC97-L cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100345,"[""Olfactory receptor 13C9""]",,"An olfactory receptor 13C9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 13C9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100345,,,,https://pharos.nih.gov/idg/targets/Q8NGT0,,,,,,,,,,,,,OR13C9,,,Q8NGT0,,,,,,,,Olfactory receptor 13C9,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400518,"[""GABRG2 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400518,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRG2 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9408,"[""acute myocardial infarction""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5844,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9408,,,,ICD9CM:410|SNOMEDCT_US_2016_03_01:266288001|NCI:C35204|SNOMEDCT_US_2016_03_01:57054005|ICD9CM:410.90|ICD9CM:410.9|SNOMEDCT_US_2016_03_01:194811003|SNOMEDCT_US_2016_03_01:155304006|SNOMEDCT_US_2016_03_01:194796000|UMLS_CUI:C0155626|ICD10CM:I21.3,,,disease_ontology,,DOID:9408,,,,,,,,,,,,,,,,,,,acute myocardial infarction,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200059,"[""CCR7 gene""]",,"A C-C chemokine receptor type 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32248] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400095,,,,,,,,"A C-C chemokine receptor type 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32248] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200059,,,,,,,,,,,,,,,,1236,CCR7,CMKBR7|EBI1|EVI1,,,,,,,,,,CCR7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400018,"[""Adenosine receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400018,,,,,,,,,,,,,,,,,,,,,,,,,,,,Adenosine receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200343,"[""OR13C5 gene""]",,"An olfactory receptor 13C5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 13C5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200343,,,,,,,,,,,,,,,,138799,OR13C5,,,,,,,,,,,OR13C5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11256,"[""typhus""]",,"A primary bacterial infectious disease that refers to a group of diseases, located_in endothelial cells of the small venous, arterial, and capillary vessels, has_material_basis_in Rickettsia bacteria, which are transmitted_by lice, transmitted_by fleas, and transmitted_by mites.",false,,,http://purl.obolibrary.org/obo/DOID_0050338,,,,,,,,"A primary bacterial infectious disease that refers to a group of diseases, located_in endothelial cells of the small venous, arterial, and capillary vessels, has_material_basis_in Rickettsia bacteria, which are transmitted_by lice, transmitted_by fleas, and transmitted_by mites.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11256,,,DOID:12353|DOID:11255,SNOMEDCT_US_2016_03_01:83838002|SNOMEDCT_US_2016_03_01:25668000|NCI:C84689|SNOMEDCT_US_2016_03_01:266205000|ICD10CM:A75.9|ICD10CM:A75.0|ICD9CM:080|UMLS_CUI:C0041471|NCI:C84688|UMLS_CUI:C0041473|SNOMEDCT_US_2016_03_01:39111003|MESH:D014438|ICD10CM:A75|SNOMEDCT_US_2016_03_01:414263007|SNOMEDCT_US_2016_03_01:187383009|ICD9CM:081.0|ICD9CM:081.9|UMLS_CUI:C0041472|MESH:D014437|ICD10CM:A75.2|SNOMEDCT_US_2016_03_01:154375001,Murine [endemic] typhus|endemic flea-borne typhus|Typhus fever|Flea typhus|epidemic louse-borne typhus|Endemic Typhus fever|Louse-borne [epidemic] typhus|Exanthematic Typhus fever,,disease_ontology,Shop typhus|Moscow typhus |Flea-borne rickettsiosis|Urban typhus|Jail fever|Ship fever|Murine typhus|Famine fever|Mexican typhus|Exanthematous typhus|Petechial fever|Louse-borne rickettsiosis|European typhus|Hospital fever|Louse-borne typhus|Prison fever|Flea-borne typhus|Typhus exanthematique|Epidemic (louse-borne) typhus|Classical typhus (fever)|Epidemic louse-borne typhus fever due to Rickettsia prowazekii|Rat flea typhus,DOID:11256,http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease|http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,typhus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300245,"[""AMPK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300116,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300245,,,,,,,,,,,,,,,,,,,,,,,,,,,,AMPK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200254,"[""NALCN gene""]",,"NALCN forms a voltage-independent, nonselective, noninactivating cation channel permeable to Na+, K+, and Ca(2+). It is responsible for the neuronal background sodium leak conductance (Lu et al., 2007 [PubMed 17448995]).[supplied by OMIM, Mar 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400363,,,,,,,,"NALCN forms a voltage-independent, nonselective, noninactivating cation channel permeable to Na+, K+, and Ca(2+). It is responsible for the neuronal background sodium leak conductance (Lu et al., 2007 [PubMed 17448995]).[supplied by OMIM, Mar 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200254,,,,,,,,,,,,,,,,259232,NALCN,VGCNL1,,,,,,,,,,NALCN gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200398,"[""OR51H1P gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200398,,,,,,,,,,,,,,,,401663,OR51H1P,OR51H1,,,,,,,,,,OR51H1P gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200120,"[""GHSR gene""]",,"A growth hormone secretagogue receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q92847] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400048,,,,,,,,"A growth hormone secretagogue receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q92847] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200120,,,,,,,,,,,,,,,,2693,GHSR,,,,,,,,,,,GHSR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000846,"[""erythroleukemia cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000737,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000846,,,,,,,BrendaTissueOBO,,BTO:0000846,,,,,,,,,,,,,,,,,,,erythroleukemia cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217536,"[""PPARD gene""]",,"This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_00217462,,,,,,,,"This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217536,,,,,,,,,,,,,,,,5467,PPARD,NR1C2|PPARB,,,,,,,,,,PPARD gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01309332,"[""5-HT3 receptor sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300374,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01309332,,,,,,,,,,,,,,,,,,,,,,,,,,,,5-HT3 receptor sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100196,"[""G-protein coupled receptor 3""]",,"A G-protein coupled receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46089] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46089] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100196,,,,https://pharos.nih.gov/idg/targets/P46089,,,,,,,,,,,,,GPR3,ACCA,,P46089,,,,,,,,G-protein coupled receptor 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200382,"[""OR4F17 gene""]",,"An olfactory receptor 4F17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4F17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200382,,,,,,,,,,,,,,,,81099,OR4F17,OR4F11P|OR4F18|OR4F19,,,,,,,,,,OR4F17 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000113,"[""DMPK kinase domain""]",,Myotonin-protein kinase; Dystrophia myotonica-protein kinase; DM; DM1; DM1PK; DMK;  MDPK; MT-PK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Myotonin-protein kinase; Dystrophia myotonica-protein kinase; DM; DM1; DM1PK; DMK;  MDPK; MT-PK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000113,,,,,,,,,,,,,,,,,,,200115,,,,,,,,,DMPK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300534,"[""Kv1.3/KCNA3 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300436,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300534,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv1.3/KCNA3 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100046,"[""Cytoplasmic tyrosine-protein kinase bmx""]",,"A cytoplasmic tyrosine-protein kinase BMX that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51813] |cytoplasmic tyrosine-protein kinase bmx (BMX)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300133,,,,,,,,"A cytoplasmic tyrosine-protein kinase BMX that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51813] |cytoplasmic tyrosine-protein kinase bmx (BMX)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100046,,,,https://pharos.nih.gov/idg/targets/P51813,,,,,,,,,,,,,BMX,,,P51813,,,,,,,,Cytoplasmic tyrosine-protein kinase bmx,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400580,"[""TRPC5 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400482,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400580,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPC5 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000358,"[""THR489 in BMX""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000358,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR489 in BMX,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001963,"[""aorta cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001963,,,,,,,BrendaTissueOBO,,BTO:0001963,,,,,,,,,,,,,,,,,,,aorta cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003173,"[""endostyle""]",,"An endostyle is a longitudinal ciliated groove on the ventral wall of the pharynx which produces mucus to gather food particles. It is found in urochordates and cephalochordates, and in the larvae of lampreys. It aids in transporting food to the esophagus. The endostyle in larval lampreys (ammocetes) metamorphoses into the thyroid gland in adults, and is regarded as being homologous to the thyroid gland in vertebrates.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001262,,,,,,,,"An endostyle is a longitudinal ciliated groove on the ventral wall of the pharynx which produces mucus to gather food particles. It is found in urochordates and cephalochordates, and in the larvae of lampreys. It aids in transporting food to the esophagus. The endostyle in larval lampreys (ammocetes) metamorphoses into the thyroid gland in adults, and is regarded as being homologous to the thyroid gland in vertebrates.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003173,,,,,,,BrendaTissueOBO,hypopharyngeal groove,BTO:0003173,,,,,,,,,,,,,,,,,,,endostyle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300302,"[""FRAY subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300187,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300302,,,,,,,,,,,,,,,,,,,,,,,,,,,,FRAY subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200764,"[""S1PR2 gene""]",,"A sphingosine 1-phosphate receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95136] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A sphingosine 1-phosphate receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95136] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200764,,,,,,,,,,,,,,,,9294,S1PR2,EDG5,,,,,,,,,,S1PR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004446,"[""S9 cell""]",,The S9 cell line and the C38 cell line were derived from the IB3-1 cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The S9 cell line and the C38 cell line were derived from the IB3-1 cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004446,Marion,2010-02-02T03:35:11Z,,,,,BrendaTissueOBO,JHU-53 cell,BTO:0004446,,,,,,,,,,,,,,,,,,,S9 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000143,"[""MET190 in M3K12""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000143,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET190 in M3K12,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000090,"[""ascidian""]",,Any of a class (Ascidiacea) of solitary or colonial sessile tunicates that have an oral and an atrial siphon.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000284,,,,,,,,Any of a class (Ascidiacea) of solitary or colonial sessile tunicates that have an oral and an atrial siphon.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000090,,,,,,,BrendaTissueOBO,sea squirt,BTO:0000090,,,,,,,,,,,,,,,,,,,ascidian,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200733,"[""P2RY12 gene""]",,"A P2Y purinoceptor 12 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H244] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400100,,,,,,,,"A P2Y purinoceptor 12 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H244] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200733,,,,,,,,,,,,,,,,64805,P2RY12,HORK3,,,,,,,,,,P2RY12 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100153,"[""Atp-sensitive inward rectifier potassium channel 14""]",,"An ATP-sensitive inward rectifier potassium channel 14 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UNX9] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300425,,,,,,,,"An ATP-sensitive inward rectifier potassium channel 14 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UNX9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100153,,,,https://pharos.nih.gov/idg/targets/Q9UNX9,,,,,,,,,,,,,KCNJ14,IRK4,,Q9UNX9,,,,,,,,Atp-sensitive inward rectifier potassium channel 14,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000168,"[""FLT3(K663Q) kinase domain""]",,Fms-related tyrosine kinase 3; CD135; FLK2; FLK-2; FLT3; FLT-3; Ly72; STK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Fms-related tyrosine kinase 3; CD135; FLK2; FLK-2; FLT3; FLT-3; Ly72; STK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000168,,,,,,,,,,,,,,,,,,,200172,,,,,,,,,FLT3(K663Q) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004111,"[""gastrointestinal stromal tumor cell""]",,A type of tumor that usually begins in cells in the wall of the gastrointestinal tract. It can be benign or malignant.,false,,,http://purl.obolibrary.org/obo/BTO_0001533|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A type of tumor that usually begins in cells in the wall of the gastrointestinal tract. It can be benign or malignant.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004111,,,,,,,BrendaTissueOBO,GIST cell,BTO:0004111,,,,,,,,,,,,,,,,,,,gastrointestinal stromal tumor cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300448,"[""H (Eag) subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300448,,,,,,,,,,,,,,,,,,,,,,,,,,,,H (Eag) subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100270,"[""P2X purinoceptor 7""]",,"A P2X purinoceptor 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99572] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300364,,,,,,,,"A P2X purinoceptor 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99572] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100270,,,,https://pharos.nih.gov/idg/targets/Q99572,,,,,,,,,,,,,P2RX7,,,Q99572,,,,,,,,P2X purinoceptor 7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001660,"[""respiratory smooth muscle""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001260,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001660,,,,,,,BrendaTissueOBO,airway smooth muscle|airway smooth muscle cell|ASM cell,BTO:0001660,,,,,,,,,,,,,,,,,,,respiratory smooth muscle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217467,"[""Hepatocyte nuclear factor-4 receptors gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00200002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217467,,,,,,,,,,,,,,,,,,,,,,,,,,,,Hepatocyte nuclear factor-4 receptors gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003068,"[""PNT-1A cell""]",,"Human prostate normal cell line, immortalised with SV40. The primary culture was obtained from the prostate of a 35 year old male at post mortem.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001019,,,,,,,,"Human prostate normal cell line, immortalised with SV40. The primary culture was obtained from the prostate of a 35 year old male at post mortem.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003068,,,,,,,BrendaTissueOBO,PNT1A cell,BTO:0003068,,,,,,,,,,,,,,,,,,,PNT-1A cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1993,"[""rectum cancer""]",,A colorectal cancer that is located_in the rectum.,false,,,http://purl.obolibrary.org/obo/DOID_9256,,,,,,,,A colorectal cancer that is located_in the rectum.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1993,,,DOID:1989,NCI:C9382|NCI:C7418|ICD10CM:C20|ICD9CM:154.1|MESH:D012004|UMLS_CUI:C0949022|SNOMEDCT_US_2016_03_01:363351006|SNOMEDCT_US_2016_03_01:93984006|SNOMEDCT_US_2016_03_01:254582000|SNOMEDCT_US_2016_03_01:187761007|SNOMEDCT_US_2016_03_01:154466004|UMLS_CUI:C0007113|SNOMEDCT_US_2016_03_01:269545009,carcinoma of the rectum|carcinoma of rectum|malignant Rectal tumor|rectal cancer|malignant rectum tumor|malignant tumor of rectum (disorder)|malignant neoplasm of rectum,,disease_ontology,cancer of rectum,DOID:1993,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,rectum cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002850,"[""theca cell""]",,Lutein cell derived from the theca interna.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Lutein cell derived from the theca interna.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002850,,,,,,,BrendaTissueOBO,theca-lutein cell|paraluteal cell|paralutein cell,BTO:0002850,,,,,,,,,,,,,,,,,,,theca cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200025,"[""ASIC1 gene""]",,"This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400376,,,,,,,,"This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200025,,,,,,,,,,,,,,,,41,ASIC1,ACCN2|BNAC2,,,,,,,,,,ASIC1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400567,"[""Kv9.2/KCNS2 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400450,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400567,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv9.2/KCNS2 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000398,"[""THR790 in EGFR(L747-E749del, A750P)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000398,,,,,,,,,,,,,,,,,,,,,,,,,,,,"THR790 in EGFR(L747-E749del, A750P)",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000136,"[""QRFP26""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000136,,,,,,,,,,,,,,,,,,,,,,,,,,,,QRFP26,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002871,"[""embryonic brain cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000669,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002871,,,,,,,BrendaTissueOBO,,BTO:0002871,,,,,,,,,,,,,,,,,,,embryonic brain cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000001,"[""CXCL12""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000001,,,,,,,,,,,,,,,,,,,,,,,,,,,,CXCL12,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005593,"[""mesocorticolimbic dopaminergic system""]",,"Because of the overlap between the mesocortical and the mesolimbic dopaminergic systems, they are often collectively referred to as the mesocorticolimbic system.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003954,,,,,,,,"Because of the overlap between the mesocortical and the mesolimbic dopaminergic systems, they are often collectively referred to as the mesocorticolimbic system.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005593,Marion,2014-03-06T11:03:41Z,,,,,BrendaTissueOBO,mesocorticolimbic dopamine system,BTO:0005593,,,,,,,,,,,,,,,,,,,mesocorticolimbic dopaminergic system,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_15647,"[""leukotriene B4""]","LTB4|5,12-Dihete|5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid|C20H32O4|5,12-Hete|InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1|5(S),12(R)-dihydroxy-6(Z),8(E),10(E),14(Z)-icosatetraenoic acid|CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O|336.230|5(S),12(R)-dihydroxy-6(Z),8(E),10(E),14(Z)-eicosatetraenoic acid|VNYSSYRCGWBHLG-AMOLWHMGSA-N|(5S,12R,6Z,8E,10E,14Z)-5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid|336.46568|(5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyeicosa-6,8,10,14-tetraenoic acid|(S-(R*,S*-(E,Z,E,Z)))-5,12-Dihydroxy-6,8,10,14-eicosatetraenoic acid|0","A leukotriene composed of (6Z,8E,10E,14Z)-icosatetraenoic acid having (5S)- and (12R)-hydroxy substituents.",false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,HMDB:HMDB01085|KEGG:C02165|PMID:20400503|CAS:71160-24-2|LIPID_MAPS_instance:LMFA03020001|PMID:20529300|Wikipedia:Leukotriene_B4|Reaxys:4235309|PMID:6271967,"A leukotriene composed of (6Z,8E,10E,14Z)-icosatetraenoic acid having (5S)- and (12R)-hydroxy substituents.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:6421|CHEBI:25024|CHEBI:10933,,"(5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid|Leukotriene B4",,chebi_ontology,"LTB4|5,12-Dihete|5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid|C20H32O4|5,12-Hete|InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1|5(S),12(R)-dihydroxy-6(Z),8(E),10(E),14(Z)-icosatetraenoic acid|CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O|336.230|5(S),12(R)-dihydroxy-6(Z),8(E),10(E),14(Z)-eicosatetraenoic acid|VNYSSYRCGWBHLG-AMOLWHMGSA-N|(5S,12R,6Z,8E,10E,14Z)-5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid|336.46568|(5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyeicosa-6,8,10,14-tetraenoic acid|(S-(R*,S*-(E,Z,E,Z)))-5,12-Dihydroxy-6,8,10,14-eicosatetraenoic acid|0",,,CHEBI:15647,,,,,,,,,,,,,,,,,,,,,,,CHEBI:15647,,,,,leukotriene B4,,CHEBI:15647,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003036,"[""hippocampal cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003036,,,,,,,BrendaTissueOBO,,BTO:0003036,,,,,,,,,,,,,,,,,,,hippocampal cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9553,"[""adrenal gland disease""]",,An endocrine system disease that is located_in the adrenal gland.,false,,,http://purl.obolibrary.org/obo/DOID_28,,,,,,,,An endocrine system disease that is located_in the adrenal gland.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9553,,,,ICD9CM:255|UMLS_CUI:C0001621|SNOMEDCT_US_2016_03_01:30171000|MESH:D000307|ICD9CM:255.9|ICD10CM:E27.9|NCI:C26690|SNOMEDCT_US_2016_03_01:154704000|SNOMEDCT_US_2016_03_01:190532009,,,disease_ontology,,DOID:9553,,,,,,,,,,,,,,,,,,,adrenal gland disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200340,"[""TTYH2 gene""]",,"This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may play a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400373,,,,,,,,"This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may play a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200340,,,,,,,,,,,,,,,,94015,TTYH2,C17orf29,,,,,,,,,,TTYH2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000168,"[""MET427 in KPCD""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000168,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET427 in KPCD,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000432,"[""TGFBR1 kinase domain""]",,"Transforming growth factor, beta receptor 1; AAT5; ACVRLK4; ALK5; ALK-5; LDS1A; LDS2A; SKR4; TGFBR1; TGFR-1",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Transforming growth factor, beta receptor 1; AAT5; ACVRLK4; ALK5; ALK-5; LDS1A; LDS2A; SKR4; TGFBR1; TGFR-1",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000432,,,,,,,,,,,,,,,,,,,200433,,,,,,,,,TGFBR1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2744,"[""pyelitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_557,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2744,,,,MESH:D011702|NCI:C34964|UMLS_CUI:C0034183|SNOMEDCT_US_2016_03_01:197780007|ICD10CM:N12|SNOMEDCT_US_2016_03_01:27174002,,,disease_ontology,,DOID:2744,,,,,,,,,,,,,,,,,,,pyelitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200050,"[""CACNB3 gene""]",,"This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400334,,,,,,,,"This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200050,,,,,,,,,,,,,,,,784,CACNB3,CACNLB3,,,,,,,,,,CACNB3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002042,"[""dendritic cell""]",,"A special type of cell that is a key regulator of the immune system, acting as a professional antigen-presenting cell, APC, capable of activating naive T cells and stimulating the growth and differentiation of B cells. Dendritic cells are found, for example, in the lymph nodes and spleen. As an APC, a dendritic cell can retain antigen for long periods on its surface, present the antigen to a T or B cell and so influence their behavior.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A special type of cell that is a key regulator of the immune system, acting as a professional antigen-presenting cell, APC, capable of activating naive T cells and stimulating the growth and differentiation of B cells. Dendritic cells are found, for example, in the lymph nodes and spleen. As an APC, a dendritic cell can retain antigen for long periods on its surface, present the antigen to a T or B cell and so influence their behavior.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002042,,,,,,,BrendaTissueOBO,interdigitating cell|reticular cell|veiled cell,BTO:0002042,,,,,,,,,,,,,,,,,,,dendritic cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000141,"[""bone marrow""]",,"The soft, fatty, vascular tissue that fills most bone cavities and is the source of red blood cells and many white blood cells.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The soft, fatty, vascular tissue that fills most bone cavities and is the source of red blood cells and many white blood cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000141,,,,,,,BrendaTissueOBO,medulla of bone|medulla ossium|medulla ossea,BTO:0000141,,,,,,,,,,,,,,,,,,,bone marrow,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400357,"[""The phagocyte (gp91(phox)) nadph oxidase family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400357,,,,,,,,,,,,,,,,,,,,,,,,,,,,The phagocyte (gp91(phox)) nadph oxidase family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400404,"[""CNGA3 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400343,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400404,,,,,,,,,,,,,,,,,,,,,,,,,,,,CNGA3 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200522,"[""TEX14 gene""]",,"The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400233,,,,,,,,"The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200522,,,,,,,,,,,,,,,,56155,TEX14,SGK307,,,,,,,,,,TEX14 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200725,"[""OXTR gene""]",,"An oxytocin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30559] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"An oxytocin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30559] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200725,,,,,,,,,,,,,,,,5021,OXTR,,,,,,,,,,,OXTR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002773,"[""salivary gland cancer cell""]",,Cancer of the salivary gland is a malignant tumor of the tissues that produce saliva.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Cancer of the salivary gland is a malignant tumor of the tissues that produce saliva.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002773,,,,,,,BrendaTissueOBO,salivary gland tumor cell|salivary gland tumour cell,BTO:0002773,,,,,,,,,,,,,,,,,,,salivary gland cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003418,"[""biceps femoris""]",,Biceps of the femur.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003178,,,,,,,,Biceps of the femur.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003418,,,,,,,BrendaTissueOBO,biceps femoris muscle,BTO:0003418,,,,,,,,,,,,,,,,,,,biceps femoris,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000325,"[""PAK3 kinase domain""]",,P21 protein (Cdc42/Rac)-activated kinase 3; bPAK; CDKN1A; hPAK3; MRX30; MRX47; OPHN3; PAK3; PAK3beta,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,P21 protein (Cdc42/Rac)-activated kinase 3; bPAK; CDKN1A; hPAK3; MRX30; MRX47; OPHN3; PAK3; PAK3beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000325,,,,,,,,,,,,,,,,,,,200304,,,,,,,,,PAK3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000372,"[""PRKX kinase domain""]",,"Protein kinase, X-linked; PKX1; PRKX",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Protein kinase, X-linked; PKX1; PRKX",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000372,,,,,,,,,,,,,,,,,,,200365,,,,,,,,,PRKX kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400377,"[""Acid-sensing ion channel 2 (ASIC2) subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400330,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400377,,,,,,,,,,,,,,,,,,,,,,,,,,,,Acid-sensing ion channel 2 (ASIC2) subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200747,"[""PTGFR gene""]",,"A prostaglandin F2-alpha receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43088] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A prostaglandin F2-alpha receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43088] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200747,,,,,,,,,,,,,,,,5737,PTGFR,,,,,,,,,,,PTGFR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2645,"[""benign mesothelioma""]",,A cell type benign neoplasm that has_material_basis in mesothelium.,false,,,http://purl.obolibrary.org/obo/DOID_0060084,,,,,,,,A cell type benign neoplasm that has_material_basis in mesothelium.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2645,,,DOID:2644,UMLS_CUI:C0025500|SNOMEDCT_US_2016_03_01:154491004|ICD10CM:C45.9|SNOMEDCT_US_2016_03_01:189837000|SNOMEDCT_US_2016_03_01:187873000|SNOMEDCT_US_2016_03_01:62064005|MESH:D008654|SNOMEDCT_US_2016_03_01:190110008|NCI:C3234|ICD10CM:C45,benign tumor of Mesothelium,,disease_ontology,,DOID:2645,,,,,,,,,,,,,,,,,,,benign mesothelioma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3603,"[""mucinous cystadenocarcinoma""]",,"A cystadenocarcinoma that derives_from epithelial cells originating in glandular tissue, with a capsulated structure and mucus-producing cells.",false,,,http://purl.obolibrary.org/obo/DOID_3111,,,,,,,,"A cystadenocarcinoma that derives_from epithelial cells originating in glandular tissue, with a capsulated structure and mucus-producing cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3603,,,,UMLS_CUI:C0206699|NCI:C3776|SNOMEDCT_US_2016_03_01:79143006|MESH:D018282|SNOMEDCT_US_2016_03_01:189692006,mucinous cystadenocarcinoma (morphologic abnormality)|Pseudomucinous cystadenocarcinoma|mucinous cystadenocarcinoma NOS (morphologic abnormality),,disease_ontology,,DOID:3603,,,,,,,,,,,,,,,,,,,mucinous cystadenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400041,"[""Formyl peptide receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400041,,,,,,,,,,,,,,,,,,,,,,,,,,,,Formyl peptide receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000249,"[""M4K3 kinase domain""]",,Mitogen-activated protein kinase kinase kinase kinase 3; GLK; KHS2; MAP4K3; MAPKKKK3; MEKKK3; RAB8IPL1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase kinase kinase kinase 3; GLK; KHS2; MAP4K3; MAPKKKK3; MEKKK3; RAB8IPL1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000249,,,,,,,,,,,,,,,,,,,200241,,,,,,,,,M4K3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100177,"[""G-protein coupled receptor 12""]",,"A G-protein coupled receptor 12 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47775] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 12 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47775] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100177,,,,https://pharos.nih.gov/idg/targets/P47775,,,,,,,,,,,,,GPR12,,,P47775,,,,,,,,G-protein coupled receptor 12,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000289,"[""MP2K4 kinase domain""]",,Dual specificity mitogen-activated protein kinase kinase 4; mitogen-activated protein kinase kinase 4; JNKK; JNKK1; MAP2K4; MAPKK4; MEK4; MKK4; PRKMK4; SEK1; SEK1/MAP2K4; SERK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Dual specificity mitogen-activated protein kinase kinase 4; mitogen-activated protein kinase kinase 4; JNKK; JNKK1; MAP2K4; MAPKK4; MEK4; MKK4; PRKMK4; SEK1; SEK1/MAP2K4; SERK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000289,,,,,,,,,,,,,,,,,,,200254,,,,,,,,,MP2K4 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000192,"[""MET637 in FER""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000192,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET637 in FER,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400500,"[""Beta-3/CHRNB3 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400500,,,,,,,,,,,,,,,,,,,,,,,,,,,,Beta-3/CHRNB3 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004830,"[""epidermal cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004830,mgr,2010-10-05T05:04:25Z,,,,,BrendaTissueOBO,,BTO:0004830,,,,,,,,,,,,,,,,,,,epidermal cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001774,"[""oral cancer cell""]",,Cancer within the mouth.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Cancer within the mouth.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001774,,,,,,,BrendaTissueOBO,,BTO:0001774,,,,,,,,,,,,,,,,,,,oral cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000315,"[""ectoderm""]",,The outer of the three germ layers of the embryo (the other two being mesoderm and endoderm). Ectoderm gives rise to epidermis and neural tissue.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000556,,,,,,,,The outer of the three germ layers of the embryo (the other two being mesoderm and endoderm). Ectoderm gives rise to epidermis and neural tissue.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000315,,,,,,,BrendaTissueOBO,,BTO:0000315,,,,,,,,,,,,,,,,,,,ectoderm,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_28,"[""endocrine system disease""]",,A disease of anatomical entity that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.,false,,,http://purl.obolibrary.org/obo/DOID_7,,,,,,,,A disease of anatomical entity that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:28,,,,ICD10CM:E34.9|NCI:C3009|UMLS_CUI:C0014130|SNOMEDCT_US_2016_03_01:267462005|SNOMEDCT_US_2016_03_01:190594008|SNOMEDCT_US_2016_03_01:154718007|SNOMEDCT_US_2016_03_01:267475005|MESH:D004700|SNOMEDCT_US_2016_03_01:127345001|SNOMEDCT_US_2016_03_01:154690007|SNOMEDCT_US_2016_03_01:362969004|SNOMEDCT_US_2016_03_01:118639003|SNOMEDCT_US_2016_03_01:154648001|SNOMEDCT_US_2016_03_01:190231001|SNOMEDCT_US_2016_03_01:67432001|SNOMEDCT_US_2016_03_01:267489000|ICD9CM:259.9,,,disease_ontology,,DOID:28,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,endocrine system disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_289,"[""endometriosis""]",,A female reproductive system disease characterized by the growth of endometrial tissue outside the uterine body.,false,,,http://purl.obolibrary.org/obo/DOID_229,,,,,,,,A female reproductive system disease characterized by the growth of endometrial tissue outside the uterine body.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:289,,,,SNOMEDCT_US_2016_03_01:155988000|SNOMEDCT_US_2016_03_01:129103003|SNOMEDCT_US_2016_03_01:266588002|SNOMEDCT_US_2016_03_01:198259004|ICD9CM:617|SNOMEDCT_US_2016_03_01:103677003|NCI:C3014|UMLS_CUI:C0014175|ICD10CM:N80|SNOMEDCT_US_2016_03_01:198246007|ICD9CM:617.9|MESH:D004715|ICD10CM:N80.9|SNOMEDCT_US_2016_03_01:11871002|EFO:0001065|SNOMEDCT_US_2016_03_01:396224008,,,disease_ontology,,DOID:289,,,,,,,,,,,,,,,,,,,endometriosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_285,"[""hairy cell leukemia""]",,A chronic lymphocytic leukemia that is characterized by over production of B cells (lymphocytes) by the bone marrow where the B cells appear hairy under a microscope.,false,,,http://purl.obolibrary.org/obo/DOID_1040,,,,,,,,A chronic lymphocytic leukemia that is characterized by over production of B cells (lymphocytes) by the bone marrow where the B cells appear hairy under a microscope.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:285,,,,SNOMEDCT_US_2016_03_01:54087003|SNOMEDCT_US_2016_03_01:188653005|ICD10CM:C91.4|SNOMEDCT_US_2016_03_01:188644003|ICD10CM:C91.40|MESH:D007943|UMLS_CUI:C0023443|NCI:C7402|SNOMEDCT_US_2016_03_01:85228003|SNOMEDCT_US_2016_03_01:190066005|ICD9CM:202.4|SNOMEDCT_US_2016_03_01:118613001,,,disease_ontology,,DOID:285,,,,,,,,,,,,,,,,,,,hairy cell leukemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9577,"[""neonatal candidiasis""]",,"A candidiasis that involves fungal infection in neonates caused by Candida species. Low birthweight and age, prolonged intravascular catheterization and the use of antibiotic drugs are the principle predisposing conditions for systemic candidiasis in neonates.",false,,,http://purl.obolibrary.org/obo/DOID_1508,,,,,,,,"A candidiasis that involves fungal infection in neonates caused by Candida species. Low birthweight and age, prolonged intravascular catheterization and the use of antibiotic drugs are the principle predisposing conditions for systemic candidiasis in neonates.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9577,,,,SNOMEDCT_US_2016_03_01:3973009|NCI:C116810|SNOMEDCT_US_2016_03_01:157121009|SNOMEDCT_US_2016_03_01:206362009|ICD10CM:P37.5|UMLS_CUI:C0276682|ICD9CM:771.7|SNOMEDCT_US_2016_03_01:414821002,Neonatal monilia infection (disorder)|Neonatal candida infection|neonatal moniliasis|Neonatal Candida infection,,disease_ontology,,DOID:9577,,,,,,,,,,,,,,,,,,,neonatal candidiasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200708,"[""OR8U1 gene""]",,"An olfactory receptor 8U1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH10] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 8U1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH10] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200708,,,,,,,,,,,,,,,,219417,OR8U1,,,,,,,,,,,OR8U1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100299,"[""Map kinase-activated protein kinase 2""]",,"A MAP kinase-activated protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49137] |MAP kinase-activated protein kinase 2 (MAPKAPK2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300289,,,,,,,,"A MAP kinase-activated protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49137] |MAP kinase-activated protein kinase 2 (MAPKAPK2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100299,,,,https://pharos.nih.gov/idg/targets/P49137,,,,,,,,,,,,,MAPKAPK2,,,P49137,,,,,,,,Map kinase-activated protein kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000067,"[""CASK kinase domain""]",,Calcium/calmodulin-dependent serine protein kinase (MAGUK family); CAGH39; CAMGUK; CASK; CMG; FGS4; FLJ22219; FLJ31914; LIN2; MICPCH; TNRC8,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Calcium/calmodulin-dependent serine protein kinase (MAGUK family); CAGH39; CAMGUK; CASK; CMG; FGS4; FLJ22219; FLJ31914; LIN2; MICPCH; TNRC8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000067,,,,,,,,,,,,,,,,,,,200070,,,,,,,,,CASK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217470,"[""Tailless-like receptors gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00200002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217470,,,,,,,,,,,,,,,,,,,,,,,,,,,,Tailless-like receptors gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001488,"[""endocrine gland""]",,"Any of various glands producing hormonal secretions that pass directly into the bloodstream. The endocrine glands include the thyroid, parathyroids, anterior and posterior pituitary, pancreas, adrenals, pineal, and gonads.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000522,,,,,,,,"Any of various glands producing hormonal secretions that pass directly into the bloodstream. The endocrine glands include the thyroid, parathyroids, anterior and posterior pituitary, pancreas, adrenals, pineal, and gonads.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001488,,,,,,,BrendaTissueOBO,ductless gland,BTO:0001488,,,,,,,,,,,,,,,,,,,endocrine gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000208,"[""KC1G1 kinase domain""]",,Casein kinase I isoform gamma-1; CK1g1; CSNK1G1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Casein kinase I isoform gamma-1; CK1g1; CSNK1G1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000208,,,,,,,,,,,,,,,,,,,200100,,,,,,,,,KC1G1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100473,"[""Rhodopsin""]",,"A rhodopsin that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08100] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A rhodopsin that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08100] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100473,,,,https://pharos.nih.gov/idg/targets/P08100,,,,,,,,,,,,,RHO,OPN2,,P08100,,,,,,,,Rhodopsin,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100386,"[""Olfactory receptor 51a7""]",,"An olfactory receptor 51A7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH64] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 51A7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH64] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100386,,,,https://pharos.nih.gov/idg/targets/Q8NH64,,,,,,,,,,,,,OR51A7,,,Q8NH64,,,,,,,,Olfactory receptor 51a7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200272,"[""TACR3 gene""]",,"A neuromedin-K receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P29371] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400066,,,,,,,,"A neuromedin-K receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P29371] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200272,,,,,,,,,,,,,,,,6870,TACR3,NK3R|TAC3R,,,,,,,,,,TACR3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000244,"[""PHE159 in MKNK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000244,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE159 in MKNK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100529,"[""Serine/threonine-protein kinase tousled-like 2""]",,"serine/threonine-protein kinase tousled-like 2 (TLK2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase tousled-like 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86UE8] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300235,,,,,,,,"serine/threonine-protein kinase tousled-like 2 (TLK2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase tousled-like 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86UE8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100529,,,,https://pharos.nih.gov/idg/targets/Q86UE8,,,,,,,,,,,,,TLK2,,,Q86UE8,,,,,,,,Serine/threonine-protein kinase tousled-like 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001546,"[""chronic lymphocytic leukemia cell""]",,"Cell of a neoplastic disease of middle or old age, characterized by excessive numbers of circulating lymphocytes of normal, mature appearance, usually B-lymphocytes; presumably a neoplastic transformation of lymphoid stem cells.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000744,,,,,,,,"Cell of a neoplastic disease of middle or old age, characterized by excessive numbers of circulating lymphocytes of normal, mature appearance, usually B-lymphocytes; presumably a neoplastic transformation of lymphoid stem cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001546,,,,,,,BrendaTissueOBO,CLL cell,BTO:0001546,,,,,,,,,,,,,,,,,,,chronic lymphocytic leukemia cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200621,"[""PRPS2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200621,,,,,,,,,,,,,,,,,,,,,,,,,,,,PRPS2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100563,"[""Serine/threonine-protein kinase vrk2""]",,"A serine/threonine-protein kinase VRK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86Y07] |serine/threonine-protein kinase VRK2 (VRK2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300243,,,,,,,,"A serine/threonine-protein kinase VRK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86Y07] |serine/threonine-protein kinase VRK2 (VRK2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100563,,,,https://pharos.nih.gov/idg/targets/Q86Y07,,,,,,,,,,,,,VRK2,,,Q86Y07,,,,,,,,Serine/threonine-protein kinase vrk2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200265,"[""MC1R gene""]",,"A melanocyte-stimulating hormone receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q01726] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400021,,,,,,,,"A melanocyte-stimulating hormone receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q01726] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200265,,,,,,,,,,,,,,,,4157,MC1R,MSHR,,,,,,,,,,MC1R gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200603,"[""OR4N5 gene""]",,"An olfactory receptor 4N5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IXE1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4N5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IXE1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200603,,,,,,,,,,,,,,,,390437,OR4N5,,,,,,,,,,,OR4N5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3410,"[""carotid artery thrombosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3407,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3410,,,,SNOMEDCT_US_2016_03_01:195181000|UMLS_CUI:C0007274|MESH:D002341|SNOMEDCT_US_2016_03_01:86003009,Carotid artery thrombosis|Carotid artery thrombosis (disorder),,disease_ontology,,DOID:3410,,,,,,,,,,,,,,,,,,,carotid artery thrombosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100004,"[""C697 in FGFR3(G697C)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100004,,,,,,,,,,,,,,,,,,,,,,,,,,,,C697 in FGFR3(G697C),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003396,"[""pontine nucleus""]",,The massive gray matter filling the basilar pons. The nuclei are of fairly homogeneous architecture and project to the cortex of the contralateral cerebellar hemisphere by way of the middle cerebellar peduncle. The pontine nuclei form a major way-station in the impulse conduction from the cerebral cortex of one hemisphere to the posterior lobe of the opposite cerebellum.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The massive gray matter filling the basilar pons. The nuclei are of fairly homogeneous architecture and project to the cortex of the contralateral cerebellar hemisphere by way of the middle cerebellar peduncle. The pontine nuclei form a major way-station in the impulse conduction from the cerebral cortex of one hemisphere to the posterior lobe of the opposite cerebellum.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003396,,,,,,,BrendaTissueOBO,nuclei pontis|pontine gray matter,BTO:0003396,,,,,,,,,,,,,,,,,,,pontine nucleus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_29101,"[""sodium(1+)""]",[Na+]|InChI=1S/Na/q+1|FKNQFGJONOIPTF-UHFFFAOYSA-N|Na|Na+|sodium|SODIUM ION|Na(+),A monoatomic monocation obtained from sodium.,false,,,http://purl.obolibrary.org/obo/CHEBI_36916,,,,,,,ChemIDplus:17341-25-2|CiteXplore:10378074|CiteXplore:16580612|Wikipedia:Sodium|HMDB:HMDB00588|CiteXplore:17066056|CiteXplore:24023812|Gmelin:15196|CiteXplore:22546835|NIST Chemistry WebBook:17341-25-2|CiteXplore:16572107|PDBeChem:NA|KEGG COMPOUND:C01330,A monoatomic monocation obtained from sodium.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:9175|CHEBI:26717|CHEBI:49766,,sodium(I) cation|sodium(1+) ion|sodium cation|sodium(1+),,chebi_ontology,[Na+]|InChI=1S/Na/q+1|FKNQFGJONOIPTF-UHFFFAOYSA-N|Na|Na+|sodium|SODIUM ION|Na(+),,,CHEBI:29101,,,,,,,,,,,,,,,,,,,,,,,CHEBI:29101,,,,,sodium(1+),,CHEBI:29101,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200015,"[""ADCK3 gene""]",,"This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400249,,,,,,,,"This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200015,,,,,,,,,,,,,,,,56997,ADCK3,CABC1,,,,,,,,,,ADCK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000065,"[""PTHrP-(1-34) (human)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000065,,,,,,,,,,,,,,,,,,,,,,,,,,,,PTHrP-(1-34) (human),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400504,"[""Epsilon/CHRNE sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400504,,,,,,,,,,,,,,,,,,,,,,,,,,,,Epsilon/CHRNE sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100074,"[""CX3C chemokine receptor 1""]",,"A CX3C chemokine receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49238] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300096,,,,,,,,"A CX3C chemokine receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49238] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100074,,,,https://pharos.nih.gov/idg/targets/P49238,,,,,,,,,,,,,CX3CR1,CMKBRL1|GPR13,,P49238,,,,,,,,CX3C chemokine receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200337,"[""OR12D2 gene""]",,"An olfactory receptor 12D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58182] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 12D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58182] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200337,,,,,,,,,,,,,,,,26529,OR12D2,,,,,,,,,,,OR12D2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200026,"[""MC2R gene""]",,"An adrenocorticotropic hormone receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q01718] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400021,,,,,,,,"An adrenocorticotropic hormone receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q01718] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200026,,,,,,,,,,,,,,,,4158,MC2R,ACTHR,,,,,,,,,,MC2R gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000149,"[""MET196 in TNK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000149,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET196 in TNK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200441,"[""OR56A5 gene""]",,"An olfactory receptor 56A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7T3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 56A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7T3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200441,,,,,,,,,,,,,,,,390084,OR56A5,OR56A5P,,,,,,,,,,OR56A5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003693,"[""natural killer large granular lymphocytic leukemia cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001546,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003693,,,,,,,BrendaTissueOBO,NK-LGL cell,BTO:0003693,,,,,,,,,,,,,,,,,,,natural killer large granular lymphocytic leukemia cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8646,"[""substance-induced psychosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2468,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8646,,,,UMLS_CUI:C0154334|ICD9CM:293.89,,,disease_ontology,,DOID:8646,,,,,,,,,,,,,,,,,,,substance-induced psychosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4306,"[""radiculopathy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4307,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4306,,,,ICD10CM:M54.1|UMLS_CUI:C0700594|SNOMEDCT_US_2016_03_01:72274001|SNOMEDCT_US_2016_03_01:394640000|ICD10CM:M54.10|MESH:D011843,"nerve root disorder|nerve root disorder, NOS",,disease_ontology,,DOID:4306,,,,,,,,,,,,,,,,,,,radiculopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5272,"[""small intestinal sarcoma""]",,A sarcoma and malignant tumor of small intestine that is located_in the small intestine.,false,,,http://purl.obolibrary.org/obo/DOID_10154,,,,,,,,A sarcoma and malignant tumor of small intestine that is located_in the small intestine.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5272,,,,UMLS_CUI:C1336007|NCI:C5335,sarcoma of the Small Intestine,,disease_ontology,,DOID:5272,,,,,,,,,,,,,,,,,,,small intestinal sarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1352,"[""paranasal sinus disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2825,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1352,,,,SNOMEDCT_US_2016_03_01:195823002|NCI:C26843|SNOMEDCT_US_2016_03_01:7393007|MESH:D010254|UMLS_CUI:C0030469,disorder of nasal sinus,,disease_ontology,,DOID:1352,,,,,,,,,,,,,,,,,,,paranasal sinus disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13521,"[""tetanus neonatorum""]",,"A tetanus that occurs in newborn babies when the birth cord stump gets dirty through cutting it with an unclean blade or applying substances containing bacteria to it. The infection has_symptom stiff body, has_symptom muscle spasms, has_symptom difficulty in breathing, and has_symptom exhaustion.",false,,,http://purl.obolibrary.org/obo/DOID_11338,,,,,,,,"A tetanus that occurs in newborn babies when the birth cord stump gets dirty through cutting it with an unclean blade or applying substances containing bacteria to it. The infection has_symptom stiff body, has_symptom muscle spasms, has_symptom difficulty in breathing, and has_symptom exhaustion.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13521,,,,SNOMEDCT_US_2016_03_01:43424001|SNOMEDCT_US_2016_03_01:206338004|ICD10CM:A33|NCI:C116814|UMLS_CUI:C0343312|SNOMEDCT_US_2016_03_01:206339007|ICD9CM:771.3,Tetanus neonatorum (disorder)|neonatal tetanus,,disease_ontology,,DOID:13521,http://purl.obolibrary.org/obo/doid#gram-positive_bacterial_infectious_disease,,,,,,,,,,,,,,,,,,tetanus neonatorum,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300102,"[""Protein kinase""]",,A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation).,false,,,http://www.drugtargetontology.org/dto/DTO_03300101,,,,,,,,A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300102,,,,,,,,,,,,,,,,,,,,,,,,,,,https://en.wikipedia.org/wiki/Protein_kinase,Protein kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1802,"[""mononeuritis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1803|http://purl.obolibrary.org/obo/DOID_1188,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1802,,,,SNOMEDCT_US_2016_03_01:32595002|SNOMEDCT_US_2016_03_01:193155002|UMLS_CUI:C0235880|ICD9CM:355.9|SNOMEDCT_US_2016_03_01:267600005,,,disease_ontology,,DOID:1802,,,,,,,,,,,,,,,,,,,mononeuritis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200249,"[""LTB4R2 gene""]",,"A leukotriene B4 receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NPC1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400033,,,,,,,,"A leukotriene B4 receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NPC1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200249,,,,,,,,,,,,,,,,56413,LTB4R2,BLT2R|BLTR2,,,,,,,,,,LTB4R2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000091,"[""MET102 in MST1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000091,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET102 in MST1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_81564,"[""resolvin D1""]","7S,8,17S-Trihydroxy-docosa-4Z,9E,11E,13Z,15E,19Z-hexaenoic acid|OIWTWACQMDFHJG-CCFUIAGSSA-N|C22H32O5|376.225|7S,8,17S-Trihydroxy-docosa-4Z,9E,11E,13Z,15E,19Z-hexaenoate|InChI=1S/C22H32O5/c1-2-3-9-14-19(23)15-10-6-4-5-7-11-16-20(24)21(25)17-12-8-13-18-22(26)27/h3-12,15-16,19-21,23-25H,2,13-14,17-18H2,1H3,(H,26,27)/b6-4-,7-5+,9-3-,12-8-,15-10+,16-11+/t19-,20+,21-/m0/s1|376.487|C(\CCC(O)=O)=C\C[C@@H]([C@@H](\C=C\C=C\C=C/C=C/[C@H](C/C=C\CC)O)O)O|7S,8R,17S-Trihydroxydocosa-4Z,9E,11E,13Z,15E,19Z-hexaenoic acid|RvD1|0","A resolvin that is docosa-4Z,9E,11E,13Z,15E,19Z-hexaenoic acid which is substituted by hydroxy groups at the 7, 8, and 17 positions (the 7S,8R,17S-stereoisomer).",false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,PMID:17090225|PMID:26808633|PMID:21359215|HMDB:HMDB03733|PMID:26630551|PMID:17244615|Reaxys:20871109|PMID:26878867|PMID:26531230|PMID:26843331|PMID:26462421|KEGG:C18178|MetaCyc:CPD66-64|PMID:27056390|PMID:26597784|PMID:27133431|PMID:26702138|PMID:26969756|PMID:27098797|PMID:27145782|PMID:27009328|LIPID_MAPS_instance:LMFA04000006,"A resolvin that is docosa-4Z,9E,11E,13Z,15E,19Z-hexaenoic acid which is substituted by hydroxy groups at the 7, 8, and 17 positions (the 7S,8R,17S-stereoisomer).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,"(4Z,7S,9E,11E,13Z,15E,17S,19Z)-7,8,17-trihydroxydocosa-4,9,11,13,15,19-hexaenoic acid",,chebi_ontology,"7S,8,17S-Trihydroxy-docosa-4Z,9E,11E,13Z,15E,19Z-hexaenoic acid|OIWTWACQMDFHJG-CCFUIAGSSA-N|C22H32O5|376.225|7S,8,17S-Trihydroxy-docosa-4Z,9E,11E,13Z,15E,19Z-hexaenoate|InChI=1S/C22H32O5/c1-2-3-9-14-19(23)15-10-6-4-5-7-11-16-20(24)21(25)17-12-8-13-18-22(26)27/h3-12,15-16,19-21,23-25H,2,13-14,17-18H2,1H3,(H,26,27)/b6-4-,7-5+,9-3-,12-8-,15-10+,16-11+/t19-,20+,21-/m0/s1|376.487|C(\CCC(O)=O)=C\C[C@@H]([C@@H](\C=C\C=C\C=C/C=C/[C@H](C/C=C\CC)O)O)O|7S,8R,17S-Trihydroxydocosa-4Z,9E,11E,13Z,15E,19Z-hexaenoic acid|RvD1|0",,,CHEBI:81564,,,,,,,,,,,,,,,,,,,,,,,CHEBI:81564,,,,,resolvin D1,,CHEBI:81564,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200210,"[""CSNK1E gene""]",,"The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400170,,,,,,,,"The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200210,,,,,,,,,,,,,,,,102800317|1454,CSNK1E,,,,,,,,,,,CSNK1E gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200308,"[""OR10H2 gene""]",,"An olfactory receptor 10H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60403] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10H2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60403] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200308,,,,,,,,,,,,,,,,26538,OR10H2,,,,,,,,,,,OR10H2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001716,"[""eggshell""]",,The hard exterior covering of an egg.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The hard exterior covering of an egg.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001716,,,,,,,BrendaTissueOBO,egg shell,BTO:0001716,,,,,,,,,,,,,,,,,,,eggshell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400523,"[""GABRR3 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400523,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRR3 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005238,"[""T-REx 293 cell""]",,Human embryonic kidney cell line stably expressing the tetracycline (Tet) repressor.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human embryonic kidney cell line stably expressing the tetracycline (Tet) repressor.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005238,XPMUser,2011-09-24T11:06:39Z,,,,,BrendaTissueOBO,T-REx  HEK-293 cell,BTO:0005238,,,,,,,,,,,,,,,,,,,T-REx 293 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2275,"[""pharyngitis""]",,"An upper respiratory tract disease involving inflammation of the throat or pharynx resulting from bacterial, viral, fungal infections or irritants like pollutants or chemical substances and smoking. The infection is often referred to as ""sore throat"". The symptoms include pain during swallowing, enlarged tonsils coated with a white discharge, runny nose, cough and slight fever.",false,,,http://purl.obolibrary.org/obo/DOID_974,,,,,,,,"An upper respiratory tract disease involving inflammation of the throat or pharynx resulting from bacterial, viral, fungal infections or irritants like pollutants or chemical substances and smoking. The infection is often referred to as ""sore throat"". The symptoms include pain during swallowing, enlarged tonsils coated with a white discharge, runny nose, cough and slight fever.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2275,,,DOID:11586|DOID:938|DOID:939|DOID:11588|DOID:10455,SNOMEDCT_US_2016_03_01:266383007|SNOMEDCT_US_2016_03_01:195784004|SNOMEDCT_US_2016_03_01:363746003|NCI:C26850|UMLS_CUI:C0031345|ICD9CM:462|SNOMEDCT_US_2016_03_01:37616004|SNOMEDCT_US_2016_03_01:75860007|ICD10CM:J02.9|SNOMEDCT_US_2016_03_01:367427004|SNOMEDCT_US_2016_03_01:405737000|MESH:D010608|MESH:D010612|UMLS_CUI:C0155824|SNOMEDCT_US_2016_03_01:195763009|SNOMEDCT_US_2016_03_01:195654001|SNOMEDCT_US_2016_03_01:195664005|SNOMEDCT_US_2016_03_01:195832000|UMLS_CUI:C0031350|NCI:C34355|SNOMEDCT_US_2016_03_01:266379007|SNOMEDCT_US_2016_03_01:164261009|SNOMEDCT_US_2016_03_01:155521003|ICD9CM:472|SNOMEDCT_US_2016_03_01:155502006|NCI:C26851|ICD10CM:J02|SNOMEDCT_US_2016_03_01:141458004|SNOMEDCT_US_2016_03_01:27321001|ICD9CM:478.20|UMLS_CUI:C0001344,chronic pharyngitis|chronic pharyngitis and nasopharyngitis|Persistent sore throat|Inflamed throat|Pharyngitis - acute|chronic pharyn/nasopharyngitis|chronic sore throat|Pharyngeal disorder|acute sore throat|Sore throat - chronic|acute pharyngitis,,disease_ontology,pharyngeal disease,DOID:2275,,,,,,,,,,,,,,,,,,,pharyngitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200477,"[""SIK3 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400314,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200477,,,,,,,,,,,,,,,,23387,SIK3,KIAA0999|QSK,,,,,,,,,,SIK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200212,"[""CSNK1G2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400170,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200212,,,,,,,,,,,,,,,,1455,CSNK1G2,CK1G2,,,,,,,,,,CSNK1G2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100571,"[""Tyrosine-protein kinase yes""]",,"A tyrosine-protein kinase Yes that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07947] |tyrosine-protein kinase yes (YES)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300132,,,,,,,,"A tyrosine-protein kinase Yes that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07947] |tyrosine-protein kinase yes (YES)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100571,,,,https://pharos.nih.gov/idg/targets/P07947,,,,,,,,,,,,,YES1,YES,,P07947,,,,,,,,Tyrosine-protein kinase yes,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002299,"[""oliva""]",,"A part of each pyramid of the medulla oblongata, between the ventrolateral and dorsolateral sulci; it is formed by an irregular mass of gray substance (nucleus olivaris caudalis) located just beneath its surface and is linked by fiber systems to the pons and cerebellum.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A part of each pyramid of the medulla oblongata, between the ventrolateral and dorsolateral sulci; it is formed by an irregular mass of gray substance (nucleus olivaris caudalis) located just beneath its surface and is linked by fiber systems to the pons and cerebellum.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002299,,,,,,,BrendaTissueOBO,olivary body|inferior olive|olivary nucleus,BTO:0002299,,,,,,,,,,,,,,,,,,,oliva,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2006,"[""preretinal fibrosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2007,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2006,,,,SNOMEDCT_US_2016_03_01:193391002|SNOMEDCT_US_2016_03_01:53428005|ICD9CM:362.56|SNOMEDCT_US_2016_03_01:367649002|SNOMEDCT_US_2016_03_01:55991001|UMLS_CUI:C0339543|MESH:D019773|SNOMEDCT_US_2016_03_01:133853005,Macular puckering of retina|cellophane maculopathy|Macular retinal puckering,,disease_ontology,,DOID:2006,,,,,,,,,,,,,,,,,,,preretinal fibrosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100475,"[""Long-wave-sensitive opsin 1""]",,"A long-wave-sensitive opsin 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P04000] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A long-wave-sensitive opsin 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P04000] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100475,,,,https://pharos.nih.gov/idg/targets/P04000,,,,,,,,,,,,,OPN1LW,RCP,,P04000,,,,,,,,Long-wave-sensitive opsin 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000270,"[""PHE691 in FLT3(D835H)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000270,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE691 in FLT3(D835H),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100068,"[""Calcium-activated chloride channel regulator 4""]",,"A calcium-activated chloride channel regulator 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14CN2] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300339,,,,,,,,"A calcium-activated chloride channel regulator 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14CN2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100068,,,,https://pharos.nih.gov/idg/targets/Q14CN2,,,,,,,,,,,,,CLCA4,CaCC2,,Q14CN2,,,,,,,,Calcium-activated chloride channel regulator 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000776,"[""B-lymphocyte""]",,Any of the lymphocytes that have antibody molecules on the surface and comprise the antibody-secreting plasma cells when mature.,false,,,http://purl.obolibrary.org/obo/BTO_0000775|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Any of the lymphocytes that have antibody molecules on the surface and comprise the antibody-secreting plasma cells when mature.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000776,,,,,,,BrendaTissueOBO,B-cell|B cell|B lymphocyte,BTO:0000776,,,,,,,,,,,,,,,,,,,B-lymphocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200625,"[""OR5H1 gene""]",,"An olfactory receptor 5H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NKK0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NKK0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200625,,,,,,,,,,,,,,,,26341,OR5H1,,,,,,,,,,,OR5H1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100168,"[""Potassium voltage-gated channel subfamily a member 10""]",,A voltage-gated potassium channel subunit KCNA10 that is encoded in the genome of human. [] ,false,,,http://www.drugtargetontology.org/dto/DTO_01300530,,,,,,,,A voltage-gated potassium channel subunit KCNA10 that is encoded in the genome of human. [] ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100168,,,,https://pharos.nih.gov/idg/targets/Q16322,,,,,,,,,,,,,KCNA10,,,Q16322,,,,,,,,Potassium voltage-gated channel subfamily a member 10,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000648,"[""intestine""]",,The tubular part of the alimentary canal that extends from the stomach to the anus.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,,The tubular part of the alimentary canal that extends from the stomach to the anus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000648,,,,,,,BrendaTissueOBO,bowel,BTO:0000648,,,,,,,,,,,,,,,,,,,intestine,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300321,"[""ChaK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300123,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300321,,,,,,,,,,,,,,,,,,,,,,,,,,,,ChaK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000063,"[""CAMK2A kinase domain""]",,Calcium/calmodulin-dependent protein kinase II alpha; CAMK2A; CAMKA; KIAA0968,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Calcium/calmodulin-dependent protein kinase II alpha; CAMK2A; CAMKA; KIAA0968,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000063,,,,,,,,,,,,,,,,,,,200063,,,,,,,,,CAMK2A kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9597,"[""Krukenberg carcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2152,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9597,,,,MESH:D007725|NCI:C3153|SNOMEDCT_US_2016_03_01:359987004|SNOMEDCT_US_2016_03_01:4305004|SNOMEDCT_US_2016_03_01:94455000|UMLS_CUI:C0022790,Krukenberg neoplasm,,disease_ontology,Krukenberg tumor,DOID:9597,,,,,,,,,,,,,,,,,,,Krukenberg carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2351,"[""iron metabolism disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0050032,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2351,,,,SNOMEDCT_US_2016_03_01:154751003|ICD9CM:275.0|MESH:D019189|SNOMEDCT_US_2016_03_01:267504005|ICD10CM:E83.10|UMLS_CUI:C0012715|SNOMEDCT_US_2016_03_01:190851008|SNOMEDCT_US_2016_03_01:30913008|ICD10CM:E83.1,disorder of iron metabolism|iron disorder|disorder of iron metabolism NOS (disorder)|Iron disorder|disorder of iron metabolism (disorder),,disease_ontology,,DOID:2351,,,,,,,,,,,,,,,,,,,iron metabolism disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200418,"[""OR52E5 gene""]",,"An olfactory receptor 52E5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH55] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 52E5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH55] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200418,,,,,,,,,,,,,,,,390082,OR52E5,,,,,,,,,,,OR52E5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200529,"[""TLK2 gene""]",,"This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400235,,,,,,,,"This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200529,,,,,,,,,,,,,,,,11011,TLK2,,,,,,,,,,,TLK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100169,"[""Voltage-gated potassium channel subunit beta-1""]",,"A voltage-gated potassium channel subunit beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14722] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300356,,,,,,,,"A voltage-gated potassium channel subunit beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14722] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100169,,,,https://pharos.nih.gov/idg/targets/Q14722,,,,,,,,,,,,,KCNAB1,KCNA1B,,Q14722,,,,,,,,Voltage-gated potassium channel subunit beta-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200266,"[""MLNR gene""]",,A motilin receptor that is encoded in the genome of human. [Reactome:REACT_21601] ,false,,,http://www.drugtargetontology.org/dto/DTO_02400064,,,,,,,,A motilin receptor that is encoded in the genome of human. [Reactome:REACT_21601] ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200266,,,,,,,,,,,,,,,,2862,MLNR,GPR38|MTLR|MTLR1,,,,,,,,,,MLNR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100174,"[""G-protein coupled receptor family c group 5 member d""]",,"A G-protein coupled receptor family C group 5 member D that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZD1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300004,,,,,,,,"A G-protein coupled receptor family C group 5 member D that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZD1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100174,,,,https://pharos.nih.gov/idg/targets/Q9NZD1,,,,,,,,,,,,,GPRC5D,,,Q9NZD1,,,,,,,,G-protein coupled receptor family c group 5 member d,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9931,"[""Waterhouse-Friderichsen syndrome""]",,An adrenal gland disease that is characterized by failure of the adrenal gland due to bleeding into the gland.,false,,,http://purl.obolibrary.org/obo/DOID_9553,,,,,,,,An adrenal gland disease that is characterized by failure of the adrenal gland due to bleeding into the gland.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9931,,,DOID:12613,SNOMEDCT_US_2016_03_01:267484005|SNOMEDCT_US_2016_03_01:154709005|MESH:D014884|NCI:C85225|UMLS_CUI:C0043068,Meningococcal hemorrhagic adrenalitis|WFS,,disease_ontology,,DOID:9931,http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease,,,,,,,,,,,,,,,,,,Waterhouse-Friderichsen syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13884,"[""sick sinus syndrome""]",,Xref MGI.,false,,,http://purl.obolibrary.org/obo/DOID_0050824,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13884,,,,SNOMEDCT_US_2016_03_01:266307005|ICD10CM:I49.5|OMIM:163800|MESH:D012804|SNOMEDCT_US_2016_03_01:155373001|SNOMEDCT_US_2016_03_01:36083008|OMIM:614090|ORDO:166282|UMLS_CUI:C0037052|OMIM:608567|NCI:C62244,sinus node infection,,disease_ontology,,DOID:13884,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,sick sinus syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_5391,"[""Glucagon""]","C153H225N43O49S|MASNOZXLGMXCHN-ZLPAWPGGSA-N|glucagon|
His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr
|
CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
|glucagonum|HSQGTFTSDYSKYLDSRRAQDFVQWLMNT|
InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1
|Glucagone|
His-ser-glu(nh2)-gly-thr-phe-thr-ser-asp-tyr-ser-lys-tyr-leu-asp-ser-arg-arg-ala-glu(NH2)-asp-phe-val-glu(NH2)-trp-leu-met-asp(NH2)-thr
","
A 29-amino acid peptide hormone consisting of His, Ser, Gln, Gly, Thr, Phe, Thr, Ser, Asp, Tyr, Ser, Lys, Tyr, Leu, Asp, Ser, Arg, Arg, Ala, Gln, Asp, Phe, Val, Gln, Trp, Leu, Met, Asn and Thr residues joined in sequence.
",false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,CiteXplore:21940356|CiteXplore:22167521|CiteXplore:22014161|Reaxys:13191924|CiteXplore:22166985|CiteXplore:22286080|CiteXplore:22334714|DrugBank:DB00040|CiteXplore:22399501|KEGG COMPOUND:C01501|ChemIDplus:9007-92-5|ChemIDplus:16941-32-5|CiteXplore:22227186|CiteXplore:22154917|KEGG COMPOUND:9007-92-5|CiteXplore:22214853|KEGG DRUG:D00116|CiteXplore:22294753|CiteXplore:22454291|Wikipedia:Glucagon|CiteXplore:22438981|CiteXplore:22318544,"
A 29-amino acid peptide hormone consisting of His, Ser, Gln, Gly, Thr, Phe, Thr, Ser, Asp, Tyr, Ser, Lys, Tyr, Leu, Asp, Ser, Arg, Arg, Ala, Gln, Asp, Phe, Val, Gln, Trp, Leu, Met, Asn and Thr residues joined in sequence.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,"
L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-alpha-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-L-threonine
|Glucagon",,chebi_ontology,"C153H225N43O49S|MASNOZXLGMXCHN-ZLPAWPGGSA-N|glucagon|
His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr
|
CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
|glucagonum|HSQGTFTSDYSKYLDSRRAQDFVQWLMNT|
InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1
|Glucagone|
His-ser-glu(nh2)-gly-thr-phe-thr-ser-asp-tyr-ser-lys-tyr-leu-asp-ser-arg-arg-ala-glu(NH2)-asp-phe-val-glu(NH2)-trp-leu-met-asp(NH2)-thr
",,,CHEBI:5391,,,,,,,,,,,,,,,,,,,,,,,CHEBI:5391,,,,,glucagon|Glucagon,,CHEBI:5391,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100208,"[""Casein kinase i isoform alpha""]",,"A casein kinase I isoform alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48729] |casein kinase i isoform alpha (CSNK1A1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300170,,,,,,,,"A casein kinase I isoform alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48729] |casein kinase i isoform alpha (CSNK1A1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100208,,,,https://pharos.nih.gov/idg/targets/P48729,,,,,,,,,,,,,CSNK1A1,,,P48729,,,,,,,,Casein kinase i isoform alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000303,"[""MYLK2 kinase domain""]",,Myosin light chain kinase 2; KMLC; MLCK; MLCK2; MYLK2; skMLCK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Myosin light chain kinase 2; KMLC; MLCK; MLCK2; MYLK2; skMLCK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000303,,,,,,,,,,,,,,,,,,,200280,,,,,,,,,MYLK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050948,"[""autosomal dominant hypophosphatemic rickets""]",,A rickets characterized by low levels of serum phosphate and elevated levels of ALP and phosphaturia and that has_material_basis_in autosomal dominant inheritance.,false,,,http://purl.obolibrary.org/obo/DOID_10609,,,,,,,,A rickets characterized by low levels of serum phosphate and elevated levels of ALP and phosphaturia and that has_material_basis_in autosomal dominant inheritance.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050948,lschriml,2015-10-01T12:10:30Z,,OMIM:193100,,,disease_ontology,,DOID:0050948,,,,,,,,,,,,,,,,,,,autosomal dominant hypophosphatemic rickets,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100470,"[""Mu-type opioid receptor""]",,"A mu-type opioid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35372] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A mu-type opioid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35372] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100470,,,,https://pharos.nih.gov/idg/targets/P35372,,,,,,,,,,,,,OPRM1,MOR1,,P35372,,,,,,,,Mu-type opioid receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100310,"[""Transmembrane channel-like protein 2""]",,"A transmembrane channel-like protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TDI7] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300372,,,,,,,,"A transmembrane channel-like protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TDI7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100310,,,,https://pharos.nih.gov/idg/targets/Q8TDI7,,,,,,,,,,,,,TMC2,C20orf145,,Q8TDI7,,,,,,,,Transmembrane channel-like protein 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000017,"[""ILE108 in SLK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30009,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000017,,,,,,,,,,,,,,,,,,,,,,,,,,,,ILE108 in SLK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4737,"[""somatoform disorder""]",,A disease of mental health that involves physical symptoms suggesting a physical illness where the biological or medical cause of the symptoms is indeterminate.,false,,,http://purl.obolibrary.org/obo/DOID_150,,,,,,,,A disease of mental health that involves physical symptoms suggesting a physical illness where the biological or medical cause of the symptoms is indeterminate.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4737,,,DOID:10133|DOID:144,UMLS_CUI:C0520482|UMLS_CUI:C0037650|SNOMEDCT_US_2016_03_01:192431008|SNOMEDCT_US_2016_03_01:191743005|ICD10CM:F45.9|MESH:D013001|SNOMEDCT_US_2016_03_01:397826007|SNOMEDCT_US_2016_03_01:60368009|ICD10CM:F45.0|ICD9CM:306.8|SNOMEDCT_US_2016_03_01:192437007|SNOMEDCT_US_2016_03_01:154892001|SNOMEDCT_US_2016_03_01:397795007|SNOMEDCT_US_2016_03_01:397923000|SNOMEDCT_US_2016_03_01:31297008|ICD10CM:F45|SNOMEDCT_US_2016_03_01:192430009|SNOMEDCT_US_2016_03_01:9514005|ICD9CM:300.81|NCI:C34956|SNOMEDCT_US_2016_03_01:192035008|UMLS_CUI:C0029824|ICD9CM:300.8,psychophysiologic disorder|physiological malfunction arising from mental factor|psychosomatic disorder,,disease_ontology,,DOID:4737,,,,,,,,,,,,,,,,,,,somatoform disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002990,"[""gastric ulcer""]",,A peptic ulcer of the gastric mucosa.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A peptic ulcer of the gastric mucosa.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002990,,,,,,,BrendaTissueOBO,,BTO:0002990,,,,,,,,,,,,,,,,,,,gastric ulcer,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200640,"[""OR5M10 gene""]",,"An olfactory receptor 5M10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IEU7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5M10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IEU7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200640,,,,,,,,,,,,,,,,390167,OR5M10,,,,,,,,,,,OR5M10 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100147,"[""Probable G-protein coupled receptor 142""]",,"A G-protein coupled receptor 142 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q7Z601] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 142 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q7Z601] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100147,,,,https://pharos.nih.gov/idg/targets/Q7Z601,,,,,,,,,,,,,GPR142,PGR2,,Q7Z601,,,,,,,,Probable G-protein coupled receptor 142,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200735,"[""P2RY14 gene""]",,"A P2Y purinoceptor 14 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15391] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400100,,,,,,,,"A P2Y purinoceptor 14 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15391] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200735,,,,,,,,,,,,,,,,9934,P2RY14,GPR105|KIAA0001,,,,,,,,,,P2RY14 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000181,"[""GSK3B kinase domain""]",,Glycogen synthase kinase 3 beta; GSK3B; GSK3beta; GSK3-beta,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Glycogen synthase kinase 3 beta; GSK3B; GSK3beta; GSK3-beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000181,,,,,,,,,,,,,,,,,,,200184,,,,,,,,,GSK3B kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14669,"[""acrodysostosis""]",,A dysostosis that results_in shortening of interphalangeal joints located_in hand or located_in foot along with mental deficiency.,false,,,http://purl.obolibrary.org/obo/DOID_1934,,,,,,,,A dysostosis that results_in shortening of interphalangeal joints located_in hand or located_in foot along with mental deficiency.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14669,,,,MESH:C538179|SNOMEDCT_US_2016_03_01:66758006|UMLS_CUI:C0220659|OMIM:614613|OMIM:101800,,,disease_ontology,,DOID:14669,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,acrodysostosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1825,"[""childhood absence epilepsy""]",,A childhood electroclinical syndrome that is characterized by brief and frequent absence seizures in children with age of onset between four and ten years.,false,,,http://purl.obolibrary.org/obo/DOID_0050704,,,,,,,,A childhood electroclinical syndrome that is characterized by brief and frequent absence seizures in children with age of onset between four and ten years.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1825,,,,SNOMEDCT_US_2016_03_01:16757004|SNOMEDCT_US_2016_03_01:192980007|UMLS_CUI:C0014553|MESH:D004832|SNOMEDCT_US_2016_03_01:192983009|NCI:C50436|SNOMEDCT_US_2016_03_01:163596002|SNOMEDCT_US_2016_03_01:50866000|SNOMEDCT_US_2016_03_01:140805008|SNOMEDCT_US_2016_03_01:432241000124101|NCI:C3023|SNOMEDCT_US_2016_03_01:155037000|ICD10CM:G40.A|SNOMEDCT_US_2016_03_01:79631006|SNOMEDCT_US_2016_03_01:230413002,petit mal seizure|pyknolepsy,,disease_ontology,absence seizure,DOID:1825,,,,,,,,,,,,,,,,,,,childhood absence epilepsy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100526,"[""Angiopoietin-1 receptor""]",,"An angiopoietin-1 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q02763] |angiopoietin-1 receptor (TIE2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300234,,,,,,,,"An angiopoietin-1 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q02763] |angiopoietin-1 receptor (TIE2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100526,,,,https://pharos.nih.gov/idg/targets/Q02763,,,,,,,,,,,,,TEK,TIE2|VMCM|VMCM1,,Q02763,,,,,,,,Angiopoietin-1 receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003360,"[""extraembryonic tissue""]",,"The structure outside the embryonic body; e.g., those membranes involved with the embryos protection and nutrition which are discarded at birth without being incorporated in its body.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000174,,,,,,,,"The structure outside the embryonic body; e.g., those membranes involved with the embryos protection and nutrition which are discarded at birth without being incorporated in its body.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003360,,,,,,,BrendaTissueOBO,extra-embryonic structure|extra-embryonic tissue|extraembryonic structure,BTO:0003360,,,,,,,,,,,,,,,,,,,extraembryonic tissue,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300066,"[""Tachykinin receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300066,,,,,,,,,,,,,,,,,,,,,,,,,,,,Tachykinin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200388,"[""OR51B4 gene""]",,"An olfactory receptor 51B4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y5P0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 51B4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y5P0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200388,,,,,,,,,,,,,,,,79339,OR51B4,,,,,,,,,,,OR51B4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000272,"[""MK01 kinase domain""]",,Mitogen-activated protein kinase 1; ERK; ERK2; ERT1; MAPK1; MAPK2; p38; p40; p41; p41mapk; P42MAPK; PRKM1; PRKM2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase 1; ERK; ERK2; ERT1; MAPK1; MAPK2; p38; p40; p41; p41mapk; P42MAPK; PRKM1; PRKM2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000272,,,,,,,,,,,,,,,,,,,200152,,,,,,,,,MK01 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200154,"[""FLT3 gene""]",,"This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400141,,,,,,,,"This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200154,,,,,,,,,,,,,,,,2322,FLT3,CD135|FLK2|STK1,,,,,,,,,,FLT3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000443,"[""TRKB kinase domain""]",,"Neurotrophic tyrosine kinase, receptor, type 2; GP145-TrkB; NTRK2; TRKB",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Neurotrophic tyrosine kinase, receptor, type 2; GP145-TrkB; NTRK2; TRKB",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000443,,,,,,,,,,,,,,,,,,,200444,,,,,,,,,TRKB kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001211,"[""breast epithelial cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001211,XPMUser,2011-02-23T09:07:03Z,,,,,BrendaTissueOBO,,BTO:0001211,,,,,,,,,,,,,,,,,,,breast epithelial cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300434,"[""KCNJ8 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300434,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ8 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300095,"[""C-C chemokine receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300031,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300095,,,,,,,,,,,,,,,,,,,,,,,,,,,,C-C chemokine receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000324,"[""PAK2 kinase domain""]",,P21 protein (Cdc42/Rac)-activated kinase 2; PAK2; PAK65; PAKgamma,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,P21 protein (Cdc42/Rac)-activated kinase 2; PAK2; PAK65; PAKgamma,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000324,,,,,,,,,,,,,,,,,,,200303,,,,,,,,,PAK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_33575,"[""Carboxylic acid""]",Carbonsaeuren|acido carboxilico|Carbonsaeure|acides carboxyliques|RC(=O)OH|acidos carboxilicos|OC([*])=O|acide carboxylique|CHO2R|Karbonsaeure,"
A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid.
",false,,,http://purl.obolibrary.org/obo/CHEBI_23367,,,,,,,Wikipedia:Carboxylic_acid|CiteXplore:17147560|CiteXplore:18433345,"
A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:23027|CHEBI:13627|CHEBI:13428,,carboxylic acids|carboxylic acid,,chebi_ontology,Carbonsaeuren|acido carboxilico|Carbonsaeure|acides carboxyliques|RC(=O)OH|acidos carboxilicos|OC([*])=O|acide carboxylique|CHO2R|Karbonsaeure,,,CHEBI:33575,,,,,,,,,,,,,,,,,,,,,,,CHEBI:33575,,,,,Carboxylic acid|carboxylic acid,,CHEBI:33575,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100151,"[""ATP-sensitive inward rectifier potassium channel 12""]",,"An ATP-sensitive inward rectifier potassium channel 12 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14500] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300423,,,,,,,,"An ATP-sensitive inward rectifier potassium channel 12 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14500] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100151,,,,https://pharos.nih.gov/idg/targets/Q14500,,,,,,,,,,,,,KCNJ12,IRK2|KCNJN1,,Q14500,,,,,,,,ATP-sensitive inward rectifier potassium channel 12,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2916,"[""hypersensitivity reaction type IV disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060056,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2916,,,,ICD10CM:C88.9|SNOMEDCT_US_2016_03_01:127071007|UMLS_CUI:C0021070|MESH:D007160|SNOMEDCT_US_2016_03_01:134363002|SNOMEDCT_US_2016_03_01:86295000,,,disease_ontology,immunoproliferative disease,DOID:2916,,,,,,,,,,,,,,,,,,,hypersensitivity reaction type IV disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100812,"[""Taste receptor type 1 member 3""]",,"A taste receptor type 1 member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7RTX0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300015,,,,,,,,"A taste receptor type 1 member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7RTX0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100812,,,,https://pharos.nih.gov/idg/targets/Q7RTX0,,,,,,,,,,,,,TAS1R3,T1R3|TR3,,Q7RTX0,,,,,,,,Taste receptor type 1 member 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3118,"[""hepatobiliary disease""]",,A gastrointestinal system disease that is located_in the liver and/or biliary tract.,false,,,http://purl.obolibrary.org/obo/DOID_77,,,,,,,,A gastrointestinal system disease that is located_in the liver and/or biliary tract.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3118,,,,UMLS_CUI:C0267792|NCI:C3959,liver and biliary tract disease,,disease_ontology,,DOID:3118,,,,,,,,,,,,,,,,,,,hepatobiliary disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100322,"[""Mitogen-activated protein kinase 10""]",,"A mitogen-activated protein kinase 10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P53779] |mitogen-activated protein kinase 10 (JNK3)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300293,,,,,,,,"A mitogen-activated protein kinase 10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P53779] |mitogen-activated protein kinase 10 (JNK3)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100322,,,,https://pharos.nih.gov/idg/targets/P53779,,,,,,,,,,,,,MAPK10,JNK3|JNK3A|PRKM10|SAPK1B,,P53779,,,,,,,,Mitogen-activated protein kinase 10,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004055,"[""COS cell""]",,A cell line derived from the african green monkey and used for transfection and cloning. The cells are simian fibroblasts (cv 1 cells) transformed by sv40 that is deficient in the origin of replication region. They express large t antigen constitutively and if transfected with a vector containing a normal sv40 origin have all the other early viral genes necessary to generate multiple copies of the vector and thus to give very high levels of expression.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A cell line derived from the african green monkey and used for transfection and cloning. The cells are simian fibroblasts (cv 1 cells) transformed by sv40 that is deficient in the origin of replication region. They express large t antigen constitutively and if transfected with a vector containing a normal sv40 origin have all the other early viral genes necessary to generate multiple copies of the vector and thus to give very high levels of expression.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004055,,,,,,,BrendaTissueOBO,,BTO:0004055,,,,,,,,,,,,,,,,,,,COS cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100759,"[""Relaxin-3 receptor 1""]",,"A relaxin-3 receptor 1 that is encoded in the genome of human. [PRO:CNx, Reactome:REACT_21738] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A relaxin-3 receptor 1 that is encoded in the genome of human. [PRO:CNx, Reactome:REACT_21738] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100759,,,,https://pharos.nih.gov/idg/targets/Q9NSD7,,,,,,,,,,,,,RXFP3,RLN3R1|SALPR,,Q9NSD7,,,,,,,,Relaxin-3 receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491031,"[""PI3K p85 subunit family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400323,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491031,,,,,,,,,,,,,,,,,,,,,,,,,,,,PI3K p85 subunit family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100203,"[""Probable G-protein coupled receptor 61""]",,"A G-protein coupled receptor 61 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BZJ8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 61 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BZJ8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100203,,,,https://pharos.nih.gov/idg/targets/Q9BZJ8,,,,,,,,,,,,,GPR61,BALGR,,Q9BZJ8,,,,,,,,Probable G-protein coupled receptor 61,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400238,"[""TSSK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400238,,,,,,,,,,,,,,,,,,,,,,,,,,,,TSSK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100183,"[""Potassium voltage-gated channel subfamily a member 4""]",,A voltage-gated potassium channel alpha subunit KCNA4 that is encoded in the genome of human. [] ,false,,,http://www.drugtargetontology.org/dto/DTO_01300535,,,,,,,,A voltage-gated potassium channel alpha subunit KCNA4 that is encoded in the genome of human. [] ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100183,,,,https://pharos.nih.gov/idg/targets/P22459,,,,,,,,,,,,,KCNA4,KCNA4L,,P22459,,,,,,,,Potassium voltage-gated channel subfamily a member 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300306,"[""PDHK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300131,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300306,,,,,,,,,,,,,,,,,,,,,,,,,,,,PDHK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005438,"[""HO-8910 cell""]",,Human epithelial ovarian cancer cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000811,,,,,,,,Human epithelial ovarian cancer cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005438,XPMUser,2013-04-22T10:09:12Z,,,,,BrendaTissueOBO,,BTO:0005438,,,,,,,,,,,,,,,,,,,HO-8910 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3664,"[""mast cell neoplasm""]",,A hematologic cancer that has_material_basis_in mast cells.,false,,,http://purl.obolibrary.org/obo/DOID_2531,,,,,,,,A hematologic cancer that has_material_basis_in mast cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3664,,,,NCI:C9295|UMLS_CUI:C0334664|SNOMEDCT_US_2016_03_01:127581004|ICD10CM:D47.0|SNOMEDCT_US_2016_03_01:190021001|SNOMEDCT_US_2016_03_01:89796001|SNOMEDCT_US_2016_03_01:414653009,mast cell tumor|Mast cell Proliferative disease|mastocytoma,,disease_ontology,,DOID:3664,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,mast cell neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100344,"[""Olfactory receptor 13C8""]",,"An olfactory receptor 13C8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 13C8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100344,,,,https://pharos.nih.gov/idg/targets/Q8NGS7,,,,,,,,,,,,,OR13C8,,,Q8NGS7,,,,,,,,Olfactory receptor 13C8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300527,"[""GLRA3 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300409,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300527,,,,,,,,,,,,,,,,,,,,,,,,,,,,GLRA3 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0014667,"[""disease of metabolism""]",,A disease that involving errors in metabolic processes of building or degradation of molecules.,false,,,http://purl.obolibrary.org/obo/DOID_4,,,,,,,,A disease that involving errors in metabolic processes of building or degradation of molecules.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0014667,,,,ICD9CM:277.9|SNOMEDCT_US_2016_03_01:30390004|ICD10CM:E88.9|UMLS_CUI:C0025517|NCI:C3235|SNOMEDCT_US_2016_03_01:267456000|SNOMEDCT_US_2016_03_01:154733004|MESH:D008659|SNOMEDCT_US_2016_03_01:75934005|SNOMEDCT_US_2016_03_01:190961002,metabolic disease ,,disease_ontology,,DOID:0014667,http://purl.obolibrary.org/obo/doid#NCIthesaurus,,,,,,,,,,,,,,,,,,disease of metabolism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000084,"[""vermiform appendix""]",,"A narrow blind tube usually about three or four inches (7.6 to 10.2 centimeters) long that extends from the cecum in the lower right-hand part of the abdomen, has much lymphoid wall tissue, normally communicates with the cavity of the cecum, and represents an atrophied terminal part of the cecum.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A narrow blind tube usually about three or four inches (7.6 to 10.2 centimeters) long that extends from the cecum in the lower right-hand part of the abdomen, has much lymphoid wall tissue, normally communicates with the cavity of the cecum, and represents an atrophied terminal part of the cecum.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000084,,,,,,,BrendaTissueOBO,appendix,BTO:0000084,,,,,,,,,,,,,,,,,,,vermiform appendix,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100133,"[""Adhesion G-protein coupled receptor G5""]",,"A G-protein coupled receptor 114 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,"A G-protein coupled receptor 114 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100133,,,,https://pharos.nih.gov/idg/targets/Q8IZF4,,,,,,,,,,,,,GPR114,ADGRG5|PGR27,,Q8IZF4,,,,,,,,Adhesion G-protein coupled receptor G5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400267,"[""Dyrk2 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400150,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400267,,,,,,,,,,,,,,,,,,,,,,,,,,,,Dyrk2 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001766,"[""neurula""]",,An embryo at an early stage of development in which neurulation begins.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000379,,,,,,,,An embryo at an early stage of development in which neurulation begins.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001766,,,,,,,BrendaTissueOBO,,BTO:0001766,,,,,,,,,,,,,,,,,,,neurula,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200420,"[""PINK1 gene""]",,"This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400208,,,,,,,,"This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200420,,,,,,,,,,,,,,,,65018,PINK1,,,,,,,,,,,PINK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200127,"[""EPHA3 gene""]",,"This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400153,,,,,,,,"This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200127,,,,,,,,,,,,,,,,2042,EPHA3,ETK|ETK1|HEK,,,,,,,,,,EPHA3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5974,"[""renal pelvis transitional cell carcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4919|http://purl.obolibrary.org/obo/DOID_4451|http://purl.obolibrary.org/obo/DOID_2671,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5974,,,,UMLS_CUI:C0238410|NCI:C7355,Urothelial cell carcinoma of renal Pelvis,,disease_ontology,,DOID:5974,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,renal pelvis transitional cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000957,"[""nape""]",,The back of the neck.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The back of the neck.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000957,,,,,,,BrendaTissueOBO,,BTO:0000957,,,,,,,,,,,,,,,,,,,nape,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200328,"[""TRPM3 gene""]",,"The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400585,,,,,,,,"The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200328,,,,,,,,,,,,,,,,80036,TRPM3,KIAA1616|LTRPC3,,,,,,,,,,TRPM3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200576,"[""GALK1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200576,,,,,,,,,,,,,,,,,,,,,,,,,,,,GALK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200130,"[""EPHA6 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400153,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200130,,,,,,,,,,,,,,,,285220,EPHA6,EHK2|HEK12,,,,,,,,,,EPHA6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3659,"[""sialuria""]",,A lysosomal storage disease characterized by increased sialic acid in the urine.,false,,,http://purl.obolibrary.org/obo/DOID_3211,,,,,,,,A lysosomal storage disease characterized by increased sialic acid in the urine.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3659,,,,UMLS_CUI:C0342853|OMIM:604369|OMIM:269921|NCI:C85067|MESH:D029461|SNOMEDCT_US_2016_03_01:238051008,,,disease_ontology,,DOID:3659,,,,,,,,,,,,,,,,,"OMIM mapping confirmed by DO. [LS].
OMIM mapping submitted by NeuroDevNet. [LS].",,sialuria,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004472,"[""mantle cell lymphoma cell""]",,"Mantle cell lymphoma is one of the rarest of the non-Hodgkin's lymphomas, comprising about 6% of NHL cases. It is a subtype of B-cell lymphoma, due to CD5 positive antigen-naive pregerminal center B-cell within the mantle zone that surrounds normal germinal center follicles.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002904,,,,,,,,"Mantle cell lymphoma is one of the rarest of the non-Hodgkin's lymphomas, comprising about 6% of NHL cases. It is a subtype of B-cell lymphoma, due to CD5 positive antigen-naive pregerminal center B-cell within the mantle zone that surrounds normal germinal center follicles.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004472,Marion,2010-02-04T10:18:47Z,,,,,BrendaTissueOBO,MCL cell,BTO:0004472,,,,,,,,,,,,,,,,,,,mantle cell lymphoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400545,"[""Kv4.1/KCND1 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400444,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400545,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv4.1/KCND1 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1056,"[""oculocerebrorenal syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050735,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1056,,,,SNOMEDCT_US_2016_03_01:79385002|NCI:C84940|MESH:D009800|ICD10CM:E72.03|OMIM:309000|UMLS_CUI:C0028860,Lowe syndrome|oculocerebrorenal syndrome of Lowe|lowe oculocerebrorenal syndrome,,disease_ontology,,DOID:1056,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,oculocerebrorenal syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002236,"[""ovarian cumulus cell""]",,The somatic granulosa cells surrounding the oocyte are termed cumulus cells.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000542,,,,,,,,The somatic granulosa cells surrounding the oocyte are termed cumulus cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002236,,,,,,,BrendaTissueOBO,cumulus cell,BTO:0002236,,,,,,,,,,,,,,,,,,,ovarian cumulus cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001921,"[""compound eye""]",,An eye (as of an insect) made up of many separate visual units.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000439,,,,,,,,An eye (as of an insect) made up of many separate visual units.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001921,,,,,,,BrendaTissueOBO,Komplexauge|zusammengesetztes Auge|Facettenauge,BTO:0001921,,,,,,,,,,,,,,,,,,,compound eye,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400478,"[""SCNN1B subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400330,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400478,,,,,,,,,,,,,,,,,,,,,,,,,,,,SCNN1B subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200310,"[""MATK gene""]",,"The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400144,,,,,,,,"The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200310,,,,,,,,,,,,,,,,4145,MATK,CTK|HYL,,,,,,,,,,MATK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002659,"[""embryonic brain cortex cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002871,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002659,,,,,,,BrendaTissueOBO,embryonic cerebral cortex cell line,BTO:0002659,,,,,,,,,,,,,,,,,,,embryonic brain cortex cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000247,"[""PHE190 in DYRK1B""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000247,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE190 in DYRK1B,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100156,"[""Probable g-protein coupled receptor 153""]",,"A G-protein coupled receptor 153 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q6NV75] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300052,,,,,,,,"A G-protein coupled receptor 153 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q6NV75] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100156,,,,https://pharos.nih.gov/idg/targets/Q6NV75,,,,,,,,,,,,,GPR153,PGR1,,Q6NV75,,,,,,,,Probable g-protein coupled receptor 153,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100261,"[""Kinase suppressor of ras 2""]",,"A kinase suppressor of Ras 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6VAB6] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300126,,,,,,,,"A kinase suppressor of Ras 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6VAB6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100261,,,,https://pharos.nih.gov/idg/targets/Q6VAB6,,,,,,,,,,,,,KSR2,,,Q6VAB6,,,,,,,,Kinase suppressor of ras 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400347,"[""FAM26 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400347,,,,,,,,,,,,,,,,,,,,,,,,,,,,FAM26 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200462,"[""OR6C76 gene""]",,"An olfactory receptor 6C76 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NM76] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6C76 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NM76] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200462,,,,,,,,,,,,,,,,390326,OR6C76,,,,,,,,,,,OR6C76 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000279,"[""MKNK1 kinase domain""]",,MAP kinase interacting serine/threonine kinase 1; MKNK1; MNK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,MAP kinase interacting serine/threonine kinase 1; MKNK1; MNK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000279,,,,,,,,,,,,,,,,,,,200264,,,,,,,,,MKNK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300281,"[""MSK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300178,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300281,,,,,,,,,,,,,,,,,,,,,,,,,,,,MSK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001234,"[""seminal vesicle""]",,Either of a pair of glandular pouches that lie one on either side of the male reproductive tract and in the human male secrete a sugar- and protein-containing fluid into the ejaculatory duct.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003096,,,,,,,,Either of a pair of glandular pouches that lie one on either side of the male reproductive tract and in the human male secrete a sugar- and protein-containing fluid into the ejaculatory duct.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001234,,,,,,,BrendaTissueOBO,seminal gland|glandula seminalis|glandula vesiculosa|vesicula seminalis,BTO:0001234,,,,,,,,,,,,,,,,,,,seminal vesicle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000003,"[""ABL1 kinase domain""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000003,,,,,,,,,,,,,,,,,,,,,,,,,,,,ABL1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200820,"[""VN1R1 gene""]",,"A vomeronasal type-1 receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZP7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400016,,,,,,,,"A vomeronasal type-1 receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZP7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200820,,,,,,,,,,,,,,,,57191,VN1R1,V1RL1|VNR19I1,,,,,,,,,,VN1R1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5637,"[""adenosquamous pancreas carcinoma""]",,A pancreatic ductal carcinoma that derives_from squamous cells and gland-like cells.,false,,,http://purl.obolibrary.org/obo/DOID_3498|http://purl.obolibrary.org/obo/DOID_4830,,,,,,,,A pancreatic ductal carcinoma that derives_from squamous cells and gland-like cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5637,,,,NCI:C5721|UMLS_CUI:C1335299,Adenosquamous carcinoma of pancreas,,disease_ontology,adenosquamous carcinoma of the pancreas,DOID:5637,,,,,,,,,,,,,,,,,,,adenosquamous pancreas carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300217,"[""RIO family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300108,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300217,,,,,,,,,,,,,,,,,,,,,,,,,,,,RIO family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300305,"[""PASK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300116,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300305,,,,,,,,,,,,,,,,,,,,,,,,,,,,PASK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000989,"[""taste bud""]",,An end organ mediating the sensation of taste and lying chiefly in the epithelium of the tongue.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,An end organ mediating the sensation of taste and lying chiefly in the epithelium of the tongue.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000989,,,,,,,BrendaTissueOBO,,BTO:0000989,,,,,,,,,,,,,,,,,,,taste bud,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10579,"[""leukodystrophy""]",,A cerebral degeneration characterized by dysfunction of the white matter of the brain.,false,,,http://purl.obolibrary.org/obo/DOID_1443,,,,,,,,A cerebral degeneration characterized by dysfunction of the white matter of the brain.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10579,,,,ICD9CM:330.0|SNOMEDCT_US_2016_03_01:5101009|SNOMEDCT_US_2016_03_01:192781003|SNOMEDCT_US_2016_03_01:192785007|UMLS_CUI:C0023520|NCI:C61253,,,disease_ontology,,DOID:10579,,,,,,,,,,,,,,,,,,,leukodystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10575,"[""calcium metabolism disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0050032,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10575,,,,ICD9CM:275.4|ICD10CM:E83.5|ICD10CM:E83.50|SNOMEDCT_US_2016_03_01:190863003|UMLS_CUI:C0006705|MESH:D002128|SNOMEDCT_US_2016_03_01:190874007|SNOMEDCT_US_2016_03_01:267442002|ICD9CM:275.40|SNOMEDCT_US_2016_03_01:71638002,,,disease_ontology,,DOID:10575,,,,,,,,,,,,,,,,,,,calcium metabolism disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10573,"[""osteomalacia""]",,A bone remodeling disease that has_material_basis_in a vitamin D deficiency which results_in softening located_in bone.,false,,,http://purl.obolibrary.org/obo/DOID_0080005,,,,,,,,A bone remodeling disease that has_material_basis_in a vitamin D deficiency which results_in softening located_in bone.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10573,,,,SNOMEDCT_US_2016_03_01:4598005|NCI:C26838|SNOMEDCT_US_2016_03_01:154728003|SNOMEDCT_US_2016_03_01:190642003|SNOMEDCT_US_2016_03_01:190639009|UMLS_CUI:C0029442|ICD9CM:268.2,,,disease_ontology,,DOID:10573,,,,,,,,,,,,,,,,,,,osteomalacia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100152,"[""Inward rectifier potassium channel 13""]",,"An inward rectifier potassium channel 13 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O60928] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300424,,,,,,,,"An inward rectifier potassium channel 13 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O60928] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100152,,,,https://pharos.nih.gov/idg/targets/O60928,,,,,,,,,,,,,KCNJ13,,,O60928,,,,,,,,Inward rectifier potassium channel 13,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400276,"[""PKC alpha subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400175,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400276,,,,,,,,,,,,,,,,,,,,,,,,,,,,PKC alpha subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200134,"[""EPHB1 gene""]",,"Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400153,,,,,,,,"Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200134,,,,,,,,,,,,,,,,2047,EPHB1,ELK|EPHT2|HEK6,,,,,,,,,,EPHB1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400566,"[""Kv9.1/KCNS1 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400450,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400566,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv9.1/KCNS1 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100269,"[""P2X purinoceptor 6""]",,"A P2X purinoceptor 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15547] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300364,,,,,,,,"A P2X purinoceptor 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15547] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100269,,,,https://pharos.nih.gov/idg/targets/O15547,,,,,,,,,,,,,P2RX6,P2RXL1|P2X6,,O15547,,,,,,,,P2X purinoceptor 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100145,"[""Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2""]",,"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9UL51] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300343,,,,,,,,"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9UL51] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100145,,,,https://pharos.nih.gov/idg/targets/Q9UL51,,,,,,,,,,,,,HCN2,BCNG2,,Q9UL51,,,,,,,,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050973,"[""spinocerebellar ataxia type 23""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1441,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050973,lschriml,2015-10-06T16:11:07Z,,OMIM:610245,,,disease_ontology,,DOID:0050973,,,,,,,,,,,,,,,,,,,spinocerebellar ataxia type 23,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050970,"[""spinocerebellar ataxia type 19/22""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1441,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050970,lschriml,2015-10-06T16:11:07Z,,OMIM:607346,,,disease_ontology,,DOID:0050970,,,,,,,,,,,,,,,,,,,spinocerebellar ataxia type 19/22,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100598,"[""Adenylate kinase isoenzyme 5""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100598,,,,,,,,,,,,,,,,,AK5,,,Q9Y6K8,,,,,,,,Adenylate kinase isoenzyme 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3763,"[""hermaphroditism""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1923,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3763,,,,MESH:D012734|SNOMEDCT_US_2016_03_01:52572004|UMLS_CUI:C0019269|SNOMEDCT_US_2016_03_01:237821001|NCI:C45909,,,disease_ontology,,DOID:3763,,,,,,,,,,,,,,,,,,,hermaphroditism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100508,"[""Serine/threonine-protein kinase 4""]",,"serine/threonine-protein kinase 4 (MST1)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase 4 that is encoded in the genome of human. [PMID:20171103, PRO:KER] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300317,,,,,,,,"serine/threonine-protein kinase 4 (MST1)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase 4 that is encoded in the genome of human. [PMID:20171103, PRO:KER] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100508,,,,https://pharos.nih.gov/idg/targets/Q13043,,,,,,,,,,,,,STK4,KRS2|MST1,,Q13043,,,,,,,,Serine/threonine-protein kinase 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100277,"[""Polycystic kidney disease protein 1-like 3""]",,"A polycystic kidney disease protein 1-like 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z443] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300367,,,,,,,,"A polycystic kidney disease protein 1-like 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z443] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100277,,,,https://pharos.nih.gov/idg/targets/Q7Z443,,,,,,,,,,,,,PKD1L3,,,Q7Z443,,,,,,,,Polycystic kidney disease protein 1-like 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491030,"[""Guanylate kinase family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400326,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491030,,,,,,,,,,,,,,,,,,,,,,,,,,,,Guanylate kinase family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000249,"[""PHE217 in PCTK3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000249,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE217 in PCTK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000324,"[""THR312 in BLK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000324,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR312 in BLK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005452,"[""C6/36 cell""]",,"Aedes albopictus, mosquito, Asian tiger larval cell line.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002632,,,,,,,,"Aedes albopictus, mosquito, Asian tiger larval cell line.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005452,XPMUser,2013-09-04T11:48:08Z,,,,,BrendaTissueOBO,,BTO:0005452,,,,,,,,,,,,,,,,,,,C6/36 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000085,"[""CCL8""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000085,,,,,,,,,,,,,,,,,,,,,,,,,,,,CCL8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100235,"[""Phosphorylase b kinase regulatory subunit alpha, liver isoform""]",,"A phosphorylase b kinase regulatory subunit alpha, liver isoform that is encoded in the genome of human. ",false,,,http://www.drugtargetontology.org/dto/DTO_03391039,,,,,,,,"A phosphorylase b kinase regulatory subunit alpha, liver isoform that is encoded in the genome of human. ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100235,,,,https://pharos.nih.gov/idg/targets/P46019,,,,,,,,,,,,,PHKA2,PHKLA|PYK,,P46019,,,,,,,,"Phosphorylase b kinase regulatory subunit alpha, liver isoform",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200002,"[""PRKAB1 gene""]",,"The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400116,,,,,,,,"The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200002,,,,,,,,,,,,,,,,5564,PRKAB1,AMPK,,,,,,,,,,PRKAB1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100323,"[""Mitogen-activated protein kinase 11""]",,"mitogen-activated protein kinase 11 (MK11)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase 11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15759] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300294,,,,,,,,"mitogen-activated protein kinase 11 (MK11)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase 11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15759] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100323,,,,https://pharos.nih.gov/idg/targets/Q15759,,,,,,,,,,,,,MAPK11,PRKM11|SAPK2|SAPK2B,,Q15759,,,,,,,,Mitogen-activated protein kinase 11,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100602,"[""Adenylate kinase 4, mitochondrial""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100602,,,,,,,,,,,,,,,,,AK4,,,P27144,,,,,,,,"Adenylate kinase 4, mitochondrial",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000615,"[""corpus callosum""]",,The great band of commissural fibers uniting the cerebral hemispheres of higher mammals including humans.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The great band of commissural fibers uniting the cerebral hemispheres of higher mammals including humans.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000615,,,,,,,BrendaTissueOBO,,BTO:0000615,,,,,,,,,,,,,,,,,,,corpus callosum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_231,"[""motor neuron disease""]",,A neurodegenerative disease that is located_in the motor neurones.,false,,,http://purl.obolibrary.org/obo/DOID_1289,,,,,,,,A neurodegenerative disease that is located_in the motor neurones.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:231,,,,SNOMEDCT_US_2016_03_01:37340000|ICD10CM:G12.20|UMLS_CUI:C0085084|SNOMEDCT_US_2016_03_01:192888001|SNOMEDCT_US_2016_03_01:155015007|SNOMEDCT_US_2016_03_01:192889009|SNOMEDCT_US_2016_03_01:192890000|ICD9CM:335.2|ICD10CM:G12.2|MESH:D016472,,,disease_ontology,,DOID:231,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,motor neuron disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_235,"[""colonic benign neoplasm""]",,An intestinal benign neoplasm that is located_in the colon.,false,,,http://purl.obolibrary.org/obo/DOID_4610,,,,,,,,An intestinal benign neoplasm that is located_in the colon.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:235,,,,UMLS_CUI:C0009375|SNOMEDCT_US_2016_03_01:126838000|MESH:D003110|NCI:C2953,Colonic Mass|colon neoplasm|Colonic tumor|neoplasm of colon (disorder),,disease_ontology,,DOID:235,,,,,,,,,,,,,,,,,,,colonic benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_234,"[""colon adenocarcinoma""]",,A colon carcinoma that derives_from epithelial cells of glandular origin.,false,,,http://purl.obolibrary.org/obo/DOID_0050913|http://purl.obolibrary.org/obo/DOID_1520,,,,,,,,A colon carcinoma that derives_from epithelial cells of glandular origin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:234,,,,SNOMEDCT_US_2016_03_01:255082000|UMLS_CUI:C0338106|NCI:C4349,adenocarcinoma of colon|Colonic adenocarcinoma,,disease_ontology,adenocarcinoma of the colon,DOID:234,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,colon adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200651,"[""OR6B1 gene""]",,"An olfactory receptor 6B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95007] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95007] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200651,,,,,,,,,,,,,,,,135946,OR6B1,,,,,,,,,,,OR6B1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200209,"[""CSNK1D gene""]",,"This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400170,,,,,,,,"This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200209,,,,,,,,,,,,,,,,1453,CSNK1D,HCKID,,,,,,,,,,CSNK1D gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100577,"[""Olfactory receptor 4D1""]",,"An olfactory receptor 4D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15615] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15615] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100577,,,,https://pharos.nih.gov/idg/targets/Q15615,,,,,,,,,,,,,OR4D1,OR4D3,,Q15615,,,,,,,,Olfactory receptor 4D1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200536,"[""TRIB2 gene""]",,"This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400237,,,,,,,,"This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200536,,,,,,,,,,,,,,,,28951,TRIB2,TRB2,,,,,,,,,,TRIB2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100452,"[""Olfactory receptor 5AR1""]",,"An olfactory receptor 5AR1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5AR1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100452,,,,https://pharos.nih.gov/idg/targets/Q8NGP9,,,,,,,,,,,,,OR5AR1,,,Q8NGP9,,,,,,,,Olfactory receptor 5AR1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9452,"[""fatty liver disease""]",,A lipid storage disease characterized by the accumulation of large vacuoles of triglyceride fat in liver cells via the process of steatosis.,false,,,http://purl.obolibrary.org/obo/DOID_9455,,,,,,,,A lipid storage disease characterized by the accumulation of large vacuoles of triglyceride fat in liver cells via the process of steatosis.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9452,,,DOID:9451,OMIM:228100|SNOMEDCT_US_2016_03_01:197321007|UMLS_CUI:C0015695|SNOMEDCT_US_2016_03_01:5360002|SNOMEDCT_US_2016_03_01:371330000|SNOMEDCT_US_2016_03_01:390002007|UMLS_CUI:C0015696|MESH:D005235|ICD10CM:K70.0|MESH:D005234|SNOMEDCT_US_2016_03_01:50325005|ICD9CM:571.0,Fatty change of liver|Steatosis of liver (disorder)|hepatic lipidosis|alcoholic fatty liver,,disease_ontology,,DOID:9452,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,PRISM.,,fatty liver disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000023,"[""ABL1(Y253F) kinase domain""]",,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000023,,,,,,,,,,,,,,,,,,,200022,,,,,,,,,ABL1(Y253F) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004719,"[""excretory canal""]",,The H-shaped excretory cell is the largest cell in Caenorabditis elegans.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001806,,,,,,,,The H-shaped excretory cell is the largest cell in Caenorabditis elegans.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004719,mgr,2010-05-18T12:40:54Z,,,,,BrendaTissueOBO,excretory canal cell,BTO:0004719,,,,,,,,,,,,,,,,,,,excretory canal,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3301,"[""gonadoblastoma""]",,A cell type benign neoplasm that is composed_of a mixture of gonadal elements.,false,,,http://purl.obolibrary.org/obo/DOID_0060084|http://purl.obolibrary.org/obo/DOID_0070003|http://purl.obolibrary.org/obo/DOID_193|http://purl.obolibrary.org/obo/DOID_0050622,,,,,,,,A cell type benign neoplasm that is composed_of a mixture of gonadal elements.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3301,,,,OMIM:424500|SNOMEDCT_US_2016_03_01:74751003|MESH:D018238|UMLS_CUI:C0206661|NCI:C3754,,,disease_ontology,,DOID:3301,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,gonadoblastoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000176,"[""carcinoma cell""]",,A cell of malignant new growth made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000415,,,,,,,,A cell of malignant new growth made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000176,,,,,,,BrendaTissueOBO,basal cell epithelioma cell|epithelial carcinoma cell|malignant epithelioma cell|epithelial cancer cell,BTO:0000176,,,,,,,,,,,,,,,,,,,carcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100649,"[""Olfactory receptor 5w2""]",,"An olfactory receptor 5W2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH69] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5W2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH69] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100649,,,,https://pharos.nih.gov/idg/targets/Q8NH69,,,,,,,,,,,,,OR5W2,OR5W2P|OR5W3P,,Q8NH69,,,,,,,,Olfactory receptor 5w2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3345,"[""xanthomatosis""]",,A lipid storage disease that is characterized by the desposition of yellowish cholesterol-rich material in tendons or other body parts.,false,,,http://purl.obolibrary.org/obo/DOID_9455,,,,,,,,A lipid storage disease that is characterized by the desposition of yellowish cholesterol-rich material in tendons or other body parts.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3345,,,,MESH:D014973|SNOMEDCT_US_2016_03_01:63103006|UMLS_CUI:C0043325,xanthelasmatosis,,disease_ontology,,DOID:3345,,,,,,,,,,,,,,,,,,,xanthomatosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391016,"[""Phosphofructokinase type A (PFKA) family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300325,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391016,,,,,,,,,,,,,,,,,,,,,,,,,,,,Phosphofructokinase type A (PFKA) family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400170,"[""CK1 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400112,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400170,,,,,,,,,,,,,,,,,,,,,,,,,,,,CK1 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060558,"[""lethal congenital contracture syndrome""]",,"A syndrome characterized by congenital nonprogressive joint contractures. The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth.",false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,"A syndrome characterized by congenital nonprogressive joint contractures. The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060558,,,,OMIM:PS253310|ICD10CM:Q68.8|ORDO:294965,,,,,,,,,,,,,,,,,,,,,,,,lethal congenital contracture syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11555,"[""Fuchs' endothelial dystrophy""]",,"A corneal dystrophy characterized by accumulation of focal outgrowths (guttae) and thickening of Descemet's membrane, leading to corneal edema and loss of vision.",false,,,http://purl.obolibrary.org/obo/DOID_0060443,,,,,,,,"A corneal dystrophy characterized by accumulation of focal outgrowths (guttae) and thickening of Descemet's membrane, leading to corneal edema and loss of vision.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11555,,,,OMIM:613270|OMIM:613271|SNOMEDCT_US_2016_03_01:193839007|UMLS_CUI:C0016781|MESH:D005642|SNOMEDCT_US_2016_03_01:393581005|ORDO:98974|OMIM:613269|OMIM:136800|OMIM:615523|SNOMEDCT_US_2016_03_01:16949007|EFO:0003946|OMIM:613267|ICD10CM:H18.51|NCI:C84721|OMIM:613268|OMIM:610158,Fuchs' corneal dystrophy|FCED|Fuchs' endothelial corneal dystrophy,,disease_ontology,,DOID:11555,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,Fuchs' endothelial dystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200063,"[""ADGRE5 gene""]",,"A CD97 molecule that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48960] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,"A CD97 molecule that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48960] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200063,,,,,,,,,,,,,,,,976,CD97,,,,,,,,,,,ADGRE5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001748,"[""mandible""]",,1: The lower jaw of a vertebrate animal. 2: Either the upper or lower part of the beak in birds.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,1: The lower jaw of a vertebrate animal. 2: Either the upper or lower part of the beak in birds.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001748,,,,,,,BrendaTissueOBO,mandibula|inferior maxillary bone|lower jaw bone,BTO:0001748,,,,,,,,,,,,,,,,,,,mandible,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003695,"[""CAD cell""]",,A CNS catecholaminergic cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003694,,,,,,,,A CNS catecholaminergic cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003695,,,,,,,BrendaTissueOBO,,BTO:0003695,,,,,,,,,,,,,,,,,,,CAD cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005067,"[""PAM212 cell""]",,1. Murine cutaneous squamous cell carcinoma cell line. 2. Murine keratinocyte cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000375|http://purl.obolibrary.org/obo/BTO_0002024,,,,,,,,1. Murine cutaneous squamous cell carcinoma cell line. 2. Murine keratinocyte cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005067,XPMUser,2011-03-07T02:37:15Z,,,,,BrendaTissueOBO,PAM 212 cell,BTO:0005067,,,,,,,,,,,,,,,,,,,PAM212 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491042,"[""RIOK3 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491036,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491042,,,,,,,,,,,,,,,,,RIOK3,,,,,,,,,,,RIOK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_63977,"[""12S-HHTrE""]","HHT|12-Hydroxyheptadecatrienoate|12-Hydroxyheptadecatrienoic acid|12S-hydroxy-5Z,8E,10E-heptadecatrienoic acid|
12(S)-Hydroxy-(5Z,8Z,10E)-heptadeca-5,8,10-trienoic acid
|CCCCC[C@H](O)\C=C\C=C\C\C=C/CCCC(O)=O|
12(S)-Hydroxy-(5Z,8Z,10E)-heptadeca-5,8,10-trienoate
|Hydroxyheptadecatrienoate|KUKJHGXXZWHSBG-WBGSEQOASA-N|
12(S)-Hydroxy-(5Z,8Z,10E)-heptadeca-5,8,10-trienoic acid anion
|
InChI=1S/C17H28O3/c1-2-3-10-13-16(18)14-11-8-6-4-5-7-9-12-15-17(19)20/h5-8,11,14,16,18H,2-4,9-10,12-13,15H2,1H3,(H,19,20)/b7-5-,8-6+,14-11+/t16-/m0/s1
|Hydroxyheptadecatrienate|Hydroxyheptadecatrienoic acid|C17H28O3|12-HHTrE|Hydroxyheptadecatrienoic acid anion|12S-HHT","
A trienoic fatty acid that consists of (5Z,8E,10E)-heptadeca-5,8,10-trienoic acid bearing an additional 12S-hydroxy substituent.
",false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,MetaCyc:1-KETO-2-METHYLVALERATE|HMDB:HMDB12535|LIPID MAPS:LMFA03050002|CiteXplore:20671299|KEGG COMPOUND:54397-84-1|Reaxys:8340574,"
A trienoic fatty acid that consists of (5Z,8E,10E)-heptadeca-5,8,10-trienoic acid bearing an additional 12S-hydroxy substituent.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,"
(5Z,8E,10E,12S)-12-hydroxyheptadeca-5,8,10-trienoic acid
",,chebi_ontology,"HHT|12-Hydroxyheptadecatrienoate|12-Hydroxyheptadecatrienoic acid|12S-hydroxy-5Z,8E,10E-heptadecatrienoic acid|
12(S)-Hydroxy-(5Z,8Z,10E)-heptadeca-5,8,10-trienoic acid
|CCCCC[C@H](O)\C=C\C=C\C\C=C/CCCC(O)=O|
12(S)-Hydroxy-(5Z,8Z,10E)-heptadeca-5,8,10-trienoate
|Hydroxyheptadecatrienoate|KUKJHGXXZWHSBG-WBGSEQOASA-N|
12(S)-Hydroxy-(5Z,8Z,10E)-heptadeca-5,8,10-trienoic acid anion
|
InChI=1S/C17H28O3/c1-2-3-10-13-16(18)14-11-8-6-4-5-7-9-12-15-17(19)20/h5-8,11,14,16,18H,2-4,9-10,12-13,15H2,1H3,(H,19,20)/b7-5-,8-6+,14-11+/t16-/m0/s1
|Hydroxyheptadecatrienate|Hydroxyheptadecatrienoic acid|C17H28O3|12-HHTrE|Hydroxyheptadecatrienoic acid anion|12S-HHT",,,CHEBI:63977,,,,,,,,,,,,,,,,,,,,,,,CHEBI:63977,,,,,12-hydroxyheptadecatrienoic acid|12S-HHTrE,,CHEBI:63977,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001518,"[""B-lymphoma cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0000104|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001518,,,,,,,BrendaTissueOBO,B-cell lymphoma cell line,BTO:0001518,,,,,,,,,,,,,,,,,,,B-lymphoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491028,"[""Type II pantothenate kinase family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400324,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491028,,,,,,,,,,,,,,,,,,,,,,,,,,,,Type II pantothenate kinase family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_83,"[""cataract""]",,A lens disease characterized by clouding of the lens inside the eye which leads to a decrease in vision.,false,,,http://purl.obolibrary.org/obo/DOID_110,,,,,,,,A lens disease characterized by clouding of the lens inside the eye which leads to a decrease in vision.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:83,,,,MESH:D002386|ICD9CM:366.8|OMIM:601371|SNOMEDCT_US_2016_03_01:193620000|UMLS_CUI:C0029531|SNOMEDCT_US_2016_03_01:193622008|ICD10CM:H26,,,disease_ontology,,DOID:83,,,,,,,,,,,,,,,,,Xref MGI.,,cataract,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100493,"[""Serine/threonine-protein kinase 32c""]",,"serine/threonine-protein kinase 32c (YANK3)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase 32C that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86UX6] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300227,,,,,,,,"serine/threonine-protein kinase 32c (YANK3)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase 32C that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86UX6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100493,,,,https://pharos.nih.gov/idg/targets/Q86UX6,,,,,,,,,,,,,STK32C,YANK3,,Q86UX6,,,,,,,,Serine/threonine-protein kinase 32c,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_4727,"[""Dynorphin A""]","InChI=1S/C69H115N23O13/c1-7-41(6)56(65(104)88-49(22-15-31-81-69(77)78)66(105)92-32-16-23-53(92)64(103)87-46(19-11-12-28-70)60(99)89-50(57(72)96)33-39(2)3)91-61(100)48(21-14-30-80-68(75)76)85-59(98)47(20-13-29-79-67(73)74)86-62(101)51(34-40(4)5)90-63(102)52(36-42-17-9-8-10-18-42)84-55(95)38-82-54(94)37-83-58(97)45(71)35-43-24-26-44(93)27-25-43/h8-10,17-18,24-27,39-41,45-53,56,93H,7,11-16,19-23,28-38,70-71H2,1-6H3,(H2,72,96)(H,82,94)(H,83,97)(H,84,95)(H,85,98)(H,86,101)(H,87,103)(H,88,104)(H,89,99)(H,90,102)(H,91,100)(H4,73,74,79)(H4,75,76,80)(H4,77,78,81)/p+1/t41?,45-,46+,47-,48-,49-,50+,51-,52-,53+,56+/m1/s1|ZIHYAUCIMOSJIH-QGLXRRFISA-O|C69H116N23O13|1474.912|1475.808|Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln|Dynorphin|+1|Dynorphin A 1-17|CCC(C)[C@H](NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC=1C=CC=CC1)NC(=O)CNC(=O)CNC(=O)[C@H](N)CC=2C=CC(O)=CC2)C(=O)N[C@H](CCCNC([NH3+])=N)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N",,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,HMDB:HMDB12935|CAS:80448-90-4|Wikipedia:dynorphin_A|PMID:1716470|KEGG:C01574|CAS:74913-18-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,(2S)-6-amino-2-{[(2S)-1-[(2R)-2-[(2S)-2-[(2R)-2-[(2R)-2-[(2R)-2-[(2R)-2-(2-{2-[(2R)-2-amino-3-(4-hydroxyphenyl)propanamido]acetamido}acetamido)-3-phenylpropanamido]-4-methylpentanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-3-methylpentanamido]-5-[(azaniumylmethanimidoyl)amino]pentanoyl]pyrrolidin-2-yl]formamido}-N-[(1S)-1-carbamoyl-3-methylbutyl]hexanamide|Dynorphin A,,chebi_ontology,"InChI=1S/C69H115N23O13/c1-7-41(6)56(65(104)88-49(22-15-31-81-69(77)78)66(105)92-32-16-23-53(92)64(103)87-46(19-11-12-28-70)60(99)89-50(57(72)96)33-39(2)3)91-61(100)48(21-14-30-80-68(75)76)85-59(98)47(20-13-29-79-67(73)74)86-62(101)51(34-40(4)5)90-63(102)52(36-42-17-9-8-10-18-42)84-55(95)38-82-54(94)37-83-58(97)45(71)35-43-24-26-44(93)27-25-43/h8-10,17-18,24-27,39-41,45-53,56,93H,7,11-16,19-23,28-38,70-71H2,1-6H3,(H2,72,96)(H,82,94)(H,83,97)(H,84,95)(H,85,98)(H,86,101)(H,87,103)(H,88,104)(H,89,99)(H,90,102)(H,91,100)(H4,73,74,79)(H4,75,76,80)(H4,77,78,81)/p+1/t41?,45-,46+,47-,48-,49-,50+,51-,52-,53+,56+/m1/s1|ZIHYAUCIMOSJIH-QGLXRRFISA-O|C69H116N23O13|1474.912|1475.808|Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln|Dynorphin|+1|Dynorphin A 1-17|CCC(C)[C@H](NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC=1C=CC=CC1)NC(=O)CNC(=O)CNC(=O)[C@H](N)CC=2C=CC(O)=CC2)C(=O)N[C@H](CCCNC([NH3+])=N)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N",,,CHEBI:4727,,,,,,,,,,,,,,,,,,,,,,,CHEBI:4727,,,,,Dynorphin A,,CHEBI:4727,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000196,"[""IRAK1 kinase domain""]",,Interleukin-1 receptor-associated kinase 1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Interleukin-1 receptor-associated kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000196,,,,,,,,,,,,,,,,,,,200199,,,,,,,,,IRAK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004901,"[""non-neuronal cell""]",,"Cell pertaining to or composed of nonconducting cells of the nervous system, e.g. neuroglial cells.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Cell pertaining to or composed of nonconducting cells of the nervous system, e.g. neuroglial cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004901,mgr,2010-10-14T11:19:48Z,,,,,BrendaTissueOBO,nonneuronal cell,BTO:0004901,,,,,,,,,,,,,,,,,,,non-neuronal cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001596,"[""MG-63 cell""]",,"Homo sapiens (human) bone, osteosarcoma cell line; established from a 14 year old caucasian male.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000407,,,,,,,,"Homo sapiens (human) bone, osteosarcoma cell line; established from a 14 year old caucasian male.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001596,,,,,,,BrendaTissueOBO,MG63 cell,BTO:0001596,,,,,,,,,,,,,,,,,,,MG-63 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004978,"[""carotid sinus nerve""]",,Carotid branch of glossopharyngeal nerve.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Carotid branch of glossopharyngeal nerve.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004978,XPMUser,2011-02-26T10:41:33Z,,,,,BrendaTissueOBO,,BTO:0004978,,,,,,,,,,,,,,,,,,,carotid sinus nerve,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217533,"[""RARB gene""]",,"This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_00217461,,,,,,,,"This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217533,,,,,,,,,,,,,,,,5915,RARB,HAP|NR1B2,,,,,,,,,,RARB gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000361,"[""THR497 in RSK4(Kin.Dom.2-C-terminal)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000361,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR497 in RSK4(Kin.Dom.2-C-terminal),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000266,"[""PHE617 in TRKB""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000266,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE617 in TRKB,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2497,"[""enamel erosion""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2498,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2497,,,,ICD9CM:521.31|UMLS_CUI:C1456161,,,disease_ontology,,DOID:2497,,,,,,,,,,,,,,,,,,,enamel erosion,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000847,"[""melanocyte""]",,An epidermal cell that produces melanin.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001470,,,,,,,,An epidermal cell that produces melanin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000847,,,,,,,BrendaTissueOBO,,BTO:0000847,,,,,,,,,,,,,,,,,,,melanocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300439,"[""KCNMB/KCNMB2 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300358,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300439,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNMB/KCNMB2 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9307,"[""rectal prolapse""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1285,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9307,,,,ICD10CM:K62.3|SNOMEDCT_US_2016_03_01:155802002|SNOMEDCT_US_2016_03_01:197212009|ICD9CM:569.1|SNOMEDCT_US_2016_03_01:197214005|NCI:C34973|SNOMEDCT_US_2016_03_01:57773001|SNOMEDCT_US_2016_03_01:197215006|MESH:D012005|UMLS_CUI:C0034888,"Procidentia, rectum",,disease_ontology,,DOID:9307,,,,,,,,,,,,,,,,,,,rectal prolapse,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200307,"[""OR10H1 gene""]",,"An olfactory receptor 10H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y4A9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y4A9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200307,,,,,,,,,,,,,,,,26539,OR10H1,,,,,,,,,,,OR10H1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003152,"[""papillary thyroid cancer cell""]",,"Cancer that forms in follicular cells in the thyroid and grows in small finger-like shapes. It grows slowly, is more common in women than in men, and often occurs before age 45. It is the most common type of thyroid cancer.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000196,,,,,,,,"Cancer that forms in follicular cells in the thyroid and grows in small finger-like shapes. It grows slowly, is more common in women than in men, and often occurs before age 45. It is the most common type of thyroid cancer.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003152,,,,,,,BrendaTissueOBO,papillary thyroid carcinoma cell,BTO:0003152,,,,,,,,,,,,,,,,,,,papillary thyroid cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6933,"[""bladder transitional cell papilloma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5432,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6933,,,DOID:2141,UMLS_CUI:C1384678|NCI:C39858|NCI:C3842|SNOMEDCT_US_2016_03_01:189459005|SNOMEDCT_US_2016_03_01:313414002|SNOMEDCT_US_2016_03_01:269642004|SNOMEDCT_US_2016_03_01:45083001|SNOMEDCT_US_2016_03_01:154620001|UMLS_CUI:C0235754,bladder papilloma NOS (disorder)|bladder papilloma NOS|Urothelial papilloma (morphologic abnormality)|transitional cell papilloma of bladder|Urothelial papilloma|bladder papilloma|urinary bladder Urothelial papilloma,,disease_ontology,,DOID:6933,,,,,,,,,,,,,,,,,,,bladder transitional cell papilloma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001427,"[""vas deferens""]",,A spermatic duct especially of a higher vertebrate that in the human male is a thick-walled tube about two feet (0.61 meters) long that begins at and is continuous with the tail of the epididymis and eventually joins the duct of the seminal vesicle to form the ejaculatory duct.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003096,,,,,,,,A spermatic duct especially of a higher vertebrate that in the human male is a thick-walled tube about two feet (0.61 meters) long that begins at and is continuous with the tail of the epididymis and eventually joins the duct of the seminal vesicle to form the ejaculatory duct.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001427,,,,,,,BrendaTissueOBO,deferent duct|ductus deferens,BTO:0001427,,,,,,,,,,,,,,,,,,,vas deferens,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200553,"[""AXL gene""]",,"The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400189,,,,,,,,"The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200553,,,,,,,,,,,,,,,,558,AXL,UFO,,,,,,,,,,AXL gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400124,"[""RIPK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400107,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400124,,,,,,,,,,,,,,,,,,,,,,,,,,,,RIPK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117503,"[""Retinoic acid receptor rxr-gamma""]",,"A retinoic acid receptor RXR-gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48443] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117468,,,,,,,,"A retinoic acid receptor RXR-gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48443] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117503,,,,https://pharos.nih.gov/idg/targets/P48443,,,,,,,,,,,,,RXRG,,,P48443,,,,,,,,Retinoic acid receptor rxr-gamma,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100049,"[""Calcitonin gene-related peptide type 1 receptor""]",,"A calcitonin gene-related peptide type 1 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16602] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300028,,,,,,,,"A calcitonin gene-related peptide type 1 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16602] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100049,,,,https://pharos.nih.gov/idg/targets/Q16602,,,,,,,,,,,,,CALCRL,CGRPR,,Q16602,,,,,,,,Calcitonin gene-related peptide type 1 receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300103,"[""Non-protein kinase""]",,A non-protein kinase is a kinase enzyme that modifies any non-protein substrates by chemically adding phosphate groups to them.,false,,,http://www.drugtargetontology.org/dto/DTO_03300101,,,,,,,,A non-protein kinase is a kinase enzyme that modifies any non-protein substrates by chemically adding phosphate groups to them.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300103,,,,,,,,,,,,,,,,,,,,,,,,,,,,Non-protein kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000116,"[""MET129 in SNARK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000116,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET129 in SNARK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200187,"[""ITPKA gene""]",,"Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03491019,,,,,,,,"Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200187,,,,,,,,,,,,,,,,3706,ITPKA,,,,,,,,,,,ITPKA gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200591,"[""OR4K2 gene""]",,"An olfactory receptor 4K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200591,,,,,,,,,,,,,,,,390431,OR4K2,,,,,,,,,,,OR4K2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200113,"[""GABBR1 gene""]",,"A gamma-aminobutyric acid type B receptor subunit 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UBS5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400045,,,,,,,,"A gamma-aminobutyric acid type B receptor subunit 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UBS5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200113,,,,,,,,,,,,,,,,2550,GABBR1,GPRC3A,,,,,,,,,,GABBR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400254,"[""PITSLRE subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400136,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400254,,,,,,,,,,,,,,,,,,,,,,,,,,,,PITSLRE subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000592,"[""adrenal gland cancer cell""]",,Adrenal gland cancers are rare cancers occuring in the endocrine tissue of the adrenals. They are characterized by overproduction of adrenal gland hormones.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Adrenal gland cancers are rare cancers occuring in the endocrine tissue of the adrenals. They are characterized by overproduction of adrenal gland hormones.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000592,,,,,,,BrendaTissueOBO,adrenal gland tumor cell,BTO:0000592,,,,,,,,,,,,,,,,,,,adrenal gland cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100004,"[""5-hydroxytryptamine receptor 3d""]",,"A 5-hydroxytryptamine receptor 3D that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q70Z44] ",false,,,http://www.drugtargetontology.org/dto/DTO_01309332,,,,,,,,"A 5-hydroxytryptamine receptor 3D that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q70Z44] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100004,,,,https://pharos.nih.gov/idg/targets/Q70Z44,,,,,,,,,,,,,HTR3D,,,Q70Z44,,,,,,,,5-hydroxytryptamine receptor 3d,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001102,"[""blood vessel""]",,Any of the vessels through which blood circulates in the body.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Any of the vessels through which blood circulates in the body.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001102,,,,,,,BrendaTissueOBO,,BTO:0001102,,,,,,,,,,,,,,,,,,,blood vessel,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_57,"[""aortic valve insufficiency""]",,"An aortic valve disease that is characterized by leaking of the aortic valve of the heart causes blood to flow in the reverse direction during ventricular diastole, from the aorta into the left ventricle.",false,,,http://purl.obolibrary.org/obo/DOID_62,,,,,,,,"An aortic valve disease that is characterized by leaking of the aortic valve of the heart causes blood to flow in the reverse direction during ventricular diastole, from the aorta into the left ventricle.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:57,,,DOID:54|DOID:55,ICD10CM:I06.1|UMLS_CUI:C0264774|UMLS_CUI:C0003504|NCI:C51223|ICD9CM:395.1|NCI:C50861|SNOMEDCT_US_2016_03_01:78031003|MESH:D001022|ICD9CM:396.3|SNOMEDCT_US_2016_03_01:60234000|SNOMEDCT_US_2016_03_01:194736003|SNOMEDCT_US_2016_03_01:155283004|UMLS_CUI:C0155568,Rheumatic aortic insufficiency|aortic regurgitation|Rheumatic aortic valve regurgitation|aortic insufficiency |rheumatic aortic valve insufficiency|Rheumatic aortic regurgitation|aortic incompetence,,disease_ontology,Corrigan's disease,DOID:57,,,,,,,,,,,,,,,,,,,aortic valve insufficiency,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_576,"[""proteinuria""]",,,false,,,http://purl.obolibrary.org/obo/DOID_557,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:576,,,,SNOMEDCT_US_2016_03_01:207315006|SNOMEDCT_US_2016_03_01:158565005|SNOMEDCT_US_2016_03_01:158568007|UMLS_CUI:C0033687|ICD10CM:R80|SNOMEDCT_US_2016_03_01:167279003|SNOMEDCT_US_2016_03_01:232691000|ICD9CM:791.0|SNOMEDCT_US_2016_03_01:207310001|SNOMEDCT_US_2016_03_01:236719005|NCI:C38012|MESH:D011507|SNOMEDCT_US_2016_03_01:144515004|ICD10CM:R80.9|SNOMEDCT_US_2016_03_01:29738008,,,disease_ontology,,DOID:576,,,,,,,,,,,,,,,,,,,proteinuria,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_572,"[""mononeuritis of upper limb and mononeuritis multiplex""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1802,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:572,,,,ICD9CM:354|UMLS_CUI:C0154741|SNOMEDCT_US_2016_03_01:193125009|SNOMEDCT_US_2016_03_01:155072002,,,disease_ontology,,DOID:572,,,,,,,,,,,,,,,,,,,mononeuritis of upper limb and mononeuritis multiplex,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_571,"[""median neuropathy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_572,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:571,,,,ICD10CM:G56.1|SNOMEDCT_US_2016_03_01:193127001|SNOMEDCT_US_2016_03_01:194512000|UMLS_CUI:C0154742|ICD10CM:G56.10|ICD9CM:354.1,,,disease_ontology,,DOID:571,,,,,,,,,,,,,,,,,,,median neuropathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_574,"[""peripheral nervous system disease""]",,A nervous system disease that affects the peripheral nervous system.,false,,,http://purl.obolibrary.org/obo/DOID_863,,,,,,,,A nervous system disease that affects the peripheral nervous system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:574,,,DOID:13069,SNOMEDCT_US_2016_03_01:193088006|SNOMEDCT_US_2016_03_01:155100008|UMLS_CUI:C1335029|SNOMEDCT_US_2016_03_01:193264002|NCI:C119734|SNOMEDCT_US_2016_03_01:155080009|SNOMEDCT_US_2016_03_01:42658009|SNOMEDCT_US_2016_03_01:155064004|NCI:C27580|MESH:D010523|SNOMEDCT_US_2016_03_01:264554005|ICD9CM:350-359.99|ICD10CM:G64|NCI:C27587|UMLS_CUI:C0031117|SNOMEDCT_US_2016_03_01:267706009|SNOMEDCT_US_2016_03_01:302226006,,,disease_ontology,peripheral neuropathy|peripheral nerve disease,DOID:574,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,peripheral nervous system disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100554,"[""Serine/threonine-protein kinase kist""]",,"A serine/threonine-protein kinase Kist that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TAS1] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300241,,,,,,,,"A serine/threonine-protein kinase Kist that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TAS1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100554,,,,https://pharos.nih.gov/idg/targets/Q8TAS1,,,,,,,,,,,,,UHMK1,KIS|KIST,,Q8TAS1,,,,,,,,Serine/threonine-protein kinase kist,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001825,"[""T-cell lymphoma cell""]",,A disease in which certain cells of the lymph system (called T-lymphocytes) become cancerous.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000785,,,,,,,,A disease in which certain cells of the lymph system (called T-lymphocytes) become cancerous.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001825,,,,,,,BrendaTissueOBO,,BTO:0001825,,,,,,,,,,,,,,,,,,,T-cell lymphoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400072,"[""Neurotensin receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400072,,,,,,,,,,,,,,,,,,,,,,,,,,,,Neurotensin receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100741,"[""Prostaglandin d2 receptor 2""]",,"A prostaglandin D2 receptor DP2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5Y4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A prostaglandin D2 receptor DP2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5Y4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100741,,,,https://pharos.nih.gov/idg/targets/Q9Y5Y4,,,,,,,,,,,,,PTGDR2,CRTH2|DL1R|GPR44,,Q9Y5Y4,,,,,,,,Prostaglandin d2 receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100014,"[""Acetylcholine receptor subunit alpha""]",,"An acetylcholine receptor subunit alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P02708] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300498,,,,,,,,"An acetylcholine receptor subunit alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P02708] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100014,,,,https://pharos.nih.gov/idg/targets/P02708,,,,,,,,,,,,,CHRNA1,ACHRA|CHNRA,,P02708,,,,,,,,Acetylcholine receptor subunit alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200414,"[""PIP5K1A gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400323,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200414,,,,,,,,,,,,,,,,8394,PIP5K1A,,,,,,,,,,,PIP5K1A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200215,"[""PNCK gene""]",,"PNCK is a member of the calcium/calmodulin-dependent protein kinase family of protein serine/threonine kinases (see CAMK1; MIM 604998) (Gardner et al., 2000 [PubMed 10673339]).[supplied by OMIM, Mar 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400171,,,,,,,,"PNCK is a member of the calcium/calmodulin-dependent protein kinase family of protein serine/threonine kinases (see CAMK1; MIM 604998) (Gardner et al., 2000 [PubMed 10673339]).[supplied by OMIM, Mar 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200215,,,,,,,,,,,,,,,,139728,PNCK,,,,,,,,,,,PNCK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100807,"[""Trace amine-associated receptor 9""]",,"A trace amine-associated receptor 9 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96RI9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A trace amine-associated receptor 9 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96RI9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100807,,,,https://pharos.nih.gov/idg/targets/Q96RI9,,,,,,,,,,,,,TAAR9,TA3|TAR3|TRAR3,,Q96RI9,,,,,,,,Trace amine-associated receptor 9,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000152,"[""MET227 in AKT1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000152,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET227 in AKT1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400191,"[""MAPK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400111,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400191,,,,,,,,,,,,,,,,,,,,,,,,,,,,MAPK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3388,"[""periodontal disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1091,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3388,,,,MESH:D010510|UMLS_CUI:C0031090|SNOMEDCT_US_2016_03_01:2556008|SNOMEDCT_US_2016_03_01:196354003|ICD10CM:K05.6|SNOMEDCT_US_2016_03_01:13877006|NCI:C63743,"periodontium disorder|Periodontal disease (disorder)|disease of supporting structures of teeth, NOS|Periodontal disease",,disease_ontology,,DOID:3388,,,,,,,,,,,,,,,,,,,periodontal disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100225,"[""Potassium channel subfamily K member 16""]",,"A potassium channel subfamily K member 16 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96T55] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300359,,,,,,,,"A potassium channel subfamily K member 16 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96T55] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100225,,,,https://pharos.nih.gov/idg/targets/Q96T55,,,,,,,,,,,,,KCNK16,TALK1,,Q96T55,,,,,,,,Potassium channel subfamily K member 16,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4990,"[""essential tremor""]",,"A movement disorder that causes involuntary tremors, especially in the hands. It occurs alone without other neurological signs and symptoms.",false,,,http://purl.obolibrary.org/obo/DOID_480,,,,,,,,"A movement disorder that causes involuntary tremors, especially in the hands. It occurs alone without other neurological signs and symptoms.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4990,,,,OMIM:190300|MESH:D020329|ICD10CM:G25.0|SNOMEDCT_US_2016_03_01:632009|ORDO:862|OMIM:602134|SNOMEDCT_US_2016_03_01:609558009|OMIM:614782|SNOMEDCT_US_2016_03_01:192839001|OMIM:611456|UMLS_CUI:C0270736,benign essential tremor|essential hereditary tremor|shaky hand syndrome,,disease_ontology,,DOID:4990,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,essential tremor,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005586,"[""polar cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005586,Marion,2014-03-05T19:59:16Z,,,,,BrendaTissueOBO,,BTO:0005586,,,,,,,,,,,,,,,,,,,polar cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300033,"[""Leukotriene receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300033,,,,,,,,,,,,,,,,,,,,,,,,,,,,Leukotriene receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100156,"[""Tyrosine-protein kinase fyn""]",,"A tyrosine-protein kinase Fyn that is encoded in the genome of human. [PRO:CNA, UniProtKB:P06241] |tyrosine-protein kinase fyn (FYN)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300132,,,,,,,,"A tyrosine-protein kinase Fyn that is encoded in the genome of human. [PRO:CNA, UniProtKB:P06241] |tyrosine-protein kinase fyn (FYN)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100156,,,,https://pharos.nih.gov/idg/targets/P06241,,,,,,,,,,,,,FYN,,,P06241,,,,,,,,Tyrosine-protein kinase fyn,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001830,"[""tassel""]",,The terminal male inflorescence of some plants and especially Indian corn.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000628,,,,,,,,The terminal male inflorescence of some plants and especially Indian corn.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001830,,,,,,,BrendaTissueOBO,,BTO:0001830,,,,,,,,,,,,,,,,,,,tassel,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100828,"[""Putative neuropeptide Y receptor type 6""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300071,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100828,,,,https://pharos.nih.gov/idg/targets/Q99463,,,,,,,,,,,,,NPY6R,NPY1RL|P16118,,Q99463,,,,,,,,Putative neuropeptide Y receptor type 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3095,"[""germ cell and embryonal cancer""]",,A germ cell cancer that is derives_from a mixture of germs cells and embryonal cells.,false,,,http://purl.obolibrary.org/obo/DOID_2994,,,,,,,,A germ cell cancer that is derives_from a mixture of germs cells and embryonal cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3095,,,,UMLS_CUI:C0027658|MESH:D009373,,,disease_ontology,germ cell and embryonal neoplasm,DOID:3095,,,,,,,,,,,,,,,,,,,germ cell and embryonal cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_63000008,"[""RIO1""]",,"A Pfam protein family that is of atypical serine kinases which are found in archaea, bacteria and eukaryotes. Activity of Rio1 is vital in Saccharomyces cerevisiae for the processing of ribosomal RNA, as well as for proper cell cycle progression and chromosome ",false,,,http://www.drugtargetontology.org/dto/DTO_63000000,,,,,,,,"A Pfam protein family that is of atypical serine kinases which are found in archaea, bacteria and eukaryotes. Activity of Rio1 is vital in Saccharomyces cerevisiae for the processing of ribosomal RNA, as well as for proper cell cycle progression and chromosome ",http://pfam.xfam.org/family/RIO1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_63000008,,,,,,,,,,,,,,,,,,,,,,,,,,,,RIO1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400050,"[""Gonadotrophin-releasing hormone receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400050,,,,,,,,,,,,,,,,,,,,,,,,,,,,Gonadotrophin-releasing hormone receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9269,"[""maple syrup urine disease""]",,"An organic acidemia that is caused by a deficiency of decarboxylase leading to high concentrations of valine, leucine, isoleucine, and alloisoleucine in the blood, urine, and cerebrospinal fluid and characterized by an odor of maple syrup to the urine, vomiting, hypertonicity, severe mental retardation, seizures, and eventually death unless the condition is treated with dietary measures.",false,,,http://purl.obolibrary.org/obo/DOID_0060159,,,,,,,,"An organic acidemia that is caused by a deficiency of decarboxylase leading to high concentrations of valine, leucine, isoleucine, and alloisoleucine in the blood, urine, and cerebrospinal fluid and characterized by an odor of maple syrup to the urine, vomiting, hypertonicity, severe mental retardation, seizures, and eventually death unless the condition is treated with dietary measures.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9269,,,,OMIM:248600|MESH:D008375|OMIM:246900|NCI:C34806|SNOMEDCT_US_2016_03_01:27718001|ORDO:511|ICD10CM:E71.0|OMIM:615135|UMLS_CUI:C0024776,Ketoacidaemia|branched chain ketoaciduria,,disease_ontology,dihydrolipoamide dehydrogenase deficiency,DOID:9269,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,maple syrup urine disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004423,"[""empyema fluid""]",,"The presence of pus in a body cavity, especially the pleural cavity.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The presence of pus in a body cavity, especially the pleural cavity.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004423,Marion,2010-02-01T02:06:20Z,,,,,BrendaTissueOBO,empyema,BTO:0004423,,,,,,,,,,,,,,,,,,,empyema fluid,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001791,"[""pleura""]",,The delicate serous membrane that lines each half of the thorax of mammals and is folded back over the surface of the lung of the same side.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The delicate serous membrane that lines each half of the thorax of mammals and is folded back over the surface of the lung of the same side.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001791,,,,,,,BrendaTissueOBO,pleural tissue,BTO:0001791,,,,,,,,,,,,,,,,,,,pleura,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100016,"[""Aarf domain-containing protein kinase 4""]",,"aarf domain-containing protein kinase 4 (ADCK4)  with  no mutation  in a nonphosphorylated state|An AarF domain-containing protein kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96D53] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300249,,,,,,,,"aarf domain-containing protein kinase 4 (ADCK4)  with  no mutation  in a nonphosphorylated state|An AarF domain-containing protein kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96D53] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100016,,,,https://pharos.nih.gov/idg/targets/Q96D53,,,,,,,,,,,,,ADCK4,,,Q96D53,,,,,,,,Aarf domain-containing protein kinase 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100342,"[""Olfactory receptor 13c4""]",,"An olfactory receptor 13C4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 13C4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100342,,,,https://pharos.nih.gov/idg/targets/Q8NGS5,,,,,,,,,,,,,OR13C4,,,Q8NGS5,,,,,,,,Olfactory receptor 13c4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002397,"[""prostate gland epithelium""]",,Normal prostatic epithelium is composed of basal and luminal cells.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000416,,,,,,,,Normal prostatic epithelium is composed of basal and luminal cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002397,,,,,,,BrendaTissueOBO,prostatic epithelium|prostate epithelium,BTO:0002397,,,,,,,,,,,,,,,,,,,prostate gland epithelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001005,"[""amnion epithelial cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001005,Marion,2010-01-28T05:56:47Z,,,,,BrendaTissueOBO,,BTO:0001005,,,,,,,,,,,,,,,,,,,amnion epithelial cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003568,"[""mammary gland cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000816,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003568,,,,,,,BrendaTissueOBO,,BTO:0003568,,,,,,,,,,,,,,,,,,,mammary gland cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000011,"[""GLN122 in MK03""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30011,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000011,,,,,,,,,,,,,,,,,,,,,,,,,,,,GLN122 in MK03,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300524,"[""GABRQ sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300524,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRQ sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200428,"[""PKN2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400210,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200428,,,,,,,,,,,,,,,,5586,PKN2,PRK2|PRKCL2,,,,,,,,,,PKN2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000146,"[""ERBB2 kinase domain""]",,Receptor tyrosine-protein kinase erbB-2; CD340; ERBB2; HER2; HER-2; HER-2/neu; MLN 19; NEU; NGL; TKR1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Receptor tyrosine-protein kinase erbB-2; CD340; ERBB2; HER2; HER-2; HER-2/neu; MLN 19; NEU; NGL; TKR1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000146,,,,,,,,,,,,,,,,,,,200148,,,,,,,,,ERBB2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_718,"[""autoimmune hemolytic anemia""]",,An autoimmune disease of blood that is characterized by deficient red blood cells caused by auto-antibodies.,false,,,http://purl.obolibrary.org/obo/DOID_0060050,,,,,,,,An autoimmune disease of blood that is characterized by deficient red blood cells caused by auto-antibodies.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:718,,,,SNOMEDCT_US_2016_03_01:191209000|CSP:0427-1178|SNOMEDCT_US_2016_03_01:25121006|NCI:C34378|SNOMEDCT_US_2016_03_01:413603009|ICD9CM:283.0|OMIM:205700|MESH:D000744|SNOMEDCT_US_2016_03_01:154803002|UMLS_CUI:C0002880|SNOMEDCT_US_2016_03_01:191215000,Autoimmune hemolytic anemia NOS (disorder)|Autoimmune haemolytic anaemia,,disease_ontology,,DOID:718,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,autoimmune hemolytic anemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_715,"[""T-cell leukemia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_9500|http://purl.obolibrary.org/obo/DOID_10747,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:715,,,,UMLS_CUI:C0023492|MESH:D015458,,,disease_ontology,,DOID:715,,,,,,,,,,,,,,,,,,,T-cell leukemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000129,"[""MET147 in MP2K2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000129,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET147 in MP2K2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200413,"[""PI4KB gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491009,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200413,,,,,,,,,,,,,,,,5298,PI4KB,PIK4CB,,,,,,,,,,PI4KB gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100175,"[""G-protein coupled receptor family c group 6 member a""]",,"A G-protein coupled receptor family C group 6 member A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5T6X5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300029,,,,,,,,"A G-protein coupled receptor family C group 6 member A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5T6X5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100175,,,,https://pharos.nih.gov/idg/targets/Q5T6X5,,,,,,,,,,,,,GPRC6A,,,Q5T6X5,,,,,,,,G-protein coupled receptor family c group 6 member a,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217534,"[""RARG gene""]",,"This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_00217461,,,,,,,,"This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217534,,,,,,,,,,,,,,,,5916,RARG,NR1B3,,,,,,,,,,RARG gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200361,"[""OR2AE1 gene""]",,"An olfactory receptor 2AE1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHA4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2AE1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHA4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200361,,,,,,,,,,,,,,,,81392,OR2AE1,OR2AE2,,,,,,,,,,OR2AE1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004977,"[""nasal lavage fluid""]",,Fluid obtained by irrigation or washout of the nasal cavity and nasal mucosa.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Fluid obtained by irrigation or washout of the nasal cavity and nasal mucosa.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004977,XPMUser,2011-02-25T09:53:31Z,,,,,BrendaTissueOBO,nasal lavage,BTO:0004977,,,,,,,,,,,,,,,,,,,nasal lavage fluid,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100325,"[""Mitogen-activated protein kinase 13""]",,"mitogen-activated protein kinase 13 (MK13)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase 13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15264] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300294,,,,,,,,"mitogen-activated protein kinase 13 (MK13)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase 13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15264] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100325,,,,https://pharos.nih.gov/idg/targets/O15264,,,,,,,,,,,,,MAPK13,PRKM13|SAPK4,,O15264,,,,,,,,Mitogen-activated protein kinase 13,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200650,"[""OR6A2 gene""]",,"An olfactory receptor 6A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95222] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95222] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200650,,,,,,,,,,,,,,,,8590,OR6A2,OR6A1|OR6A2P,,,,,,,,,,OR6A2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100476,"[""Visual pigment-like receptor peropsin""]",,"A visual pigment-like receptor peropsin that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14718] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A visual pigment-like receptor peropsin that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14718] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100476,,,,https://pharos.nih.gov/idg/targets/O14718,,,,,,,,,,,,,RRH,,,O14718,,,,,,,,Visual pigment-like receptor peropsin,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200244,"[""LPHN1 gene""]",,"A latrophilin-1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O94910] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400039,,,,,,,,"A latrophilin-1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O94910] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200244,,,,,,,,,,,,,,,,22859,LPHN1,KIAA0821|LEC2,,,,,,,,,,LPHN1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200328,"[""OR11A1 gene""]",,"An olfactory receptor 11A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZK7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 11A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZK7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200328,,,,,,,,,,,,,,,,26531,OR11A1,OR11A2,,,,,,,,,,OR11A1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/UBERON_0002385,"[""muscle tissue""]",textus muscularis|muscular tissue|portion of muscle tissue,Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO].,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001485|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,http://www.snomedbrowser.com/Codes/Details/91727004|http://linkedlifedata.com/resource/umls/id/C2328219|http://en.wikipedia.org/wiki/Muscle_tissue|galen:MuscleTissue|EHDAA2:0003122|ncithesaurus:Muscle_Tissue|FMA:9641|UMLS:C2328219|AEO:0000122|MESH:A02.633|MA:0002437|CALOHA:TS-0642|AAO:0000306,Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO].,,,,,,,,,,One of the four types of tissue in traditional classifications. Tissue that contains cells with contractile filaments that move past each other and change the size of the cell. Muscle tissue also is separated into three distinct categories.[AAO],,,,,,,,,,,,,,,,,,,,,,,,,,textus muscularis|muscular tissue|portion of muscle tissue,,uberon,,,,,,,,,,,,,,,,,,,,,,,,,,,UBERON:0002385,,,"Vertebrate muscle is categorized into three major muscle types defined by their structural and functional properties: skeletal, cardiac and smooth. In Dmel the counterparts are somatic, heart/cardiac and visceral. Here we take a cell type based approach.",,muscle tissue,,UBERON:0002385,,http://purl.obolibrary.org/obo/uberon.owl,http://purl.obolibrary.org/obo/uberon/core#uberon_slim,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003751,"[""submucosal gland""]",,"Gland of the lamina epithelialis mucosae which perforate the lamina muscularis, with their adenomeres located in the submucosal connective tissue.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001979,,,,,,,,"Gland of the lamina epithelialis mucosae which perforate the lamina muscularis, with their adenomeres located in the submucosal connective tissue.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003751,,,,,,,BrendaTissueOBO,,BTO:0003751,,,,,,,,,,,,,,,,,,,submucosal gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200006,"[""ABL1 gene""]",,"This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400117,,,,,,,,"This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200006,,,,,,,,,,,,,,,,25,ABL1,ABL|JTK7,,,,,,,,,,ABL1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200422,"[""OR52I1 gene""]",,"An olfactory receptor 52I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 52I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200422,,,,,,,,,,,,,,,,390037,OR52I1,,,,,,,,,,,OR52I1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003093,"[""cardiofibroblast""]",,A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000452,,,,,,,,A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003093,XPMUser,2011-02-23T06:37:01Z,,,,,BrendaTissueOBO,cardiac fibroblast,BTO:0003093,,,,,,,,,,,,,,,,,,,cardiofibroblast,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100061,"[""Y835 in FLT3(D835Y)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100061,,,,,,,,,,,,,,,,,,,,,,,,,,,,Y835 in FLT3(D835Y),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_17351,"[""linoleic acid""]","(9Z,12Z)-Octadecadienoic acid|CCCCC\C=C/C\C=C/CCCCCCCC(O)=O|acido linoleico|9Z,12Z-octadecadienoic acid|all-cis-9,12-octadecadienoic acid|acide linoleique|cis,cis-9,12-octadecadienoic acid|280.240|acide cis-linoleique|9-cis,12-cis-Octadecadienoic acid|InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6-,10-9-|(Z,Z)-9,12-octadecadienoic acid|linolic acid|C18:2 9c, 12c omega6 todos cis-9,12-octadienoico|LA|C18:2, n-6,9 all-cis|cis,cis-linoleic acid|cis-Delta(9,12)-octadecadienoic acid|280.44550|0|C18H32O2|OYHQOLUKZRVURQ-HZJYTTRNSA-N",An octadecadienoic acid in which the two double bonds are at positions 9 and 12 and have Z (cis) stereochemistry.,false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,KNApSAcK:C00001224|PMID:15969511|PMID:14993245|LIPID_MAPS_instance:LMFA01030120|PMID:23900039|PMID:15115315|PMID:24081493|PMID:6205897|PMID:17647039|Reaxys:1727101|Beilstein:1727101|PMID:11322990|PMID:14667063|Drug_Central:3323|PMID:18044828|Gmelin:57557|Wikipedia:Linoleic_acid|PMID:19936816|PMID:16254037|KEGG:C01595|MetaCyc:LINOLEIC_ACID|PMID:11113630|PMID:19628674|PMID:18990554|PMID:15642793|PDBeChem:EIC|HMDB:HMDB00673|CAS:60-33-3|PMID:11304127|PMID:16563718,An octadecadienoic acid in which the two double bonds are at positions 9 and 12 and have Z (cis) stereochemistry.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:42395|CHEBI:25047|CHEBI:6479,,"(9Z,12Z)-octadeca-9,12-dienoic acid|LINOLEIC ACID|Linoleic acid",,chebi_ontology,"(9Z,12Z)-Octadecadienoic acid|CCCCC\C=C/C\C=C/CCCCCCCC(O)=O|acido linoleico|9Z,12Z-octadecadienoic acid|all-cis-9,12-octadecadienoic acid|acide linoleique|cis,cis-9,12-octadecadienoic acid|280.240|acide cis-linoleique|9-cis,12-cis-Octadecadienoic acid|InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6-,10-9-|(Z,Z)-9,12-octadecadienoic acid|linolic acid|C18:2 9c, 12c omega6 todos cis-9,12-octadienoico|LA|C18:2, n-6,9 all-cis|cis,cis-linoleic acid|cis-Delta(9,12)-octadecadienoic acid|280.44550|0|C18H32O2|OYHQOLUKZRVURQ-HZJYTTRNSA-N",,,CHEBI:17351,,,,,,,,,,,,,,,,,,,,,,,CHEBI:17351,,,,,linoleic acid,,CHEBI:17351,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000848,"[""melanoma cell""]",,"A cell of a form of skin cancer that arises in melanocytes, the cells that produce pigment. Melanoma usually begins in a mole.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001286,,,,,,,,"A cell of a form of skin cancer that arises in melanocytes, the cells that produce pigment. Melanoma usually begins in a mole.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000848,,,,,,,BrendaTissueOBO,,BTO:0000848,,,,,,,,,,,,,,,,,,,melanoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001143,"[""pupa""]",,"An intermediate usually quiescent stage of a metamorphic insect as a bee, moth, or beetle that occurs between the larva and the imago, is usually enclosed in a cocoon or protective covering, and undergoes internal changes by which larval structures are replaced by those typical of the imago.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000174,,,,,,,,"An intermediate usually quiescent stage of a metamorphic insect as a bee, moth, or beetle that occurs between the larva and the imago, is usually enclosed in a cocoon or protective covering, and undergoes internal changes by which larval structures are replaced by those typical of the imago.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001143,,,,,,,BrendaTissueOBO,,BTO:0001143,,,,,,,,,,,,,,,,,,,pupa,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100055,"[""Voltage-dependent calcium channel gamma-1 subunit""]",,"A voltage-dependent calcium channel gamma-1 subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q06432] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300336,,,,,,,,"A voltage-dependent calcium channel gamma-1 subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q06432] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100055,,,,https://pharos.nih.gov/idg/targets/Q06432,,,,,,,,,,,,,CACNG1,CACNLG,,Q06432,,,,,,,,Voltage-dependent calcium channel gamma-1 subunit,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1803,"[""neuritis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_870,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1803,,,,SNOMEDCT_US_2016_03_01:84299009|SNOMEDCT_US_2016_03_01:247378004|MESH:D009443|SNOMEDCT_US_2016_03_01:128192007|UMLS_CUI:C0027813|SNOMEDCT_US_2016_03_01:123254001|NCI:C116381|SNOMEDCT_US_2016_03_01:203116001,peripheral neuritis,,disease_ontology,,DOID:1803,,,,,,,,,,,,,,,,,,,neuritis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100320,"[""Olfactory receptor 10q1""]",,"An olfactory receptor 10Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100320,,,,https://pharos.nih.gov/idg/targets/Q8NGQ4,,,,,,,,,,,,,OR10Q1,,,Q8NGQ4,,,,,,,,Olfactory receptor 10q1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200199,"[""GPR4 gene""]",,"A G-protein coupled receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46093] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400053,,,,,,,,"A G-protein coupled receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46093] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200199,,,,,,,,,,,,,,,,2828,GPR4,GPR19,,,,,,,,,,GPR4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000208,"[""caryopsis""]",,"Simple, dry, indehiscent fruit with a single seed that is fused to the ovary wall, example: wheat.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000486,,,,,,,,"Simple, dry, indehiscent fruit with a single seed that is fused to the ovary wall, example: wheat.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000208,,,,,,,BrendaTissueOBO,grain,BTO:0000208,,,,,,,,,,,,,,,,,,,caryopsis,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491034,"[""HUNK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400116,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491034,,,,,,,,,,,,,,,,,,,,,,,,,,,,HUNK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003178,"[""biceps""]",,A muscle having two heads: as a: the large flexor muscle of the front of the upper arm b: the large flexor muscle of the back of the upper leg.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001257|http://purl.obolibrary.org/obo/BTO_0003179,,,,,,,,A muscle having two heads: as a: the large flexor muscle of the front of the upper arm b: the large flexor muscle of the back of the upper leg.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003178,,,,,,,BrendaTissueOBO,,BTO:0003178,,,,,,,,,,,,,,,,,,,biceps,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4896,"[""bile duct adenocarcinoma""]",,A bile duct carcinoma that derives_from epithelial cells of glandular origin.,false,,,http://purl.obolibrary.org/obo/DOID_299|http://purl.obolibrary.org/obo/DOID_4897,,,,,,,,A bile duct carcinoma that derives_from epithelial cells of glandular origin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4896,,,,SNOMEDCT_US_2016_03_01:70179006|NCI:C27813|UMLS_CUI:C1370800,,,disease_ontology,,DOID:4896,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,bile duct adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300383,"[""CACNA1C subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300333,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300383,,,,,,,,,,,,,,,,,,,,,,,,,,,,CACNA1C subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100757,"[""Retinoic acid-induced protein 3""]",,"A retinoic acid-induced protein 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFJ5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300004,,,,,,,,"A retinoic acid-induced protein 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFJ5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100757,,,,https://pharos.nih.gov/idg/targets/Q8NFJ5,,,,,,,,,,,,,GPRC5A,GPCR5A|RAI3|RAIG1,,Q8NFJ5,,,,,,,,Retinoic acid-induced protein 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002342,"[""bradyzoite""]",,"A small, comma-shaped form of Toxoplasma gondii, found in clusters enclosed by an irregular wall (pseudocyst) in the tissues, chiefly muscles and the brain, in chronic (latent) toxoplasmosis; considered to be the slow-growing form.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002272,,,,,,,,"A small, comma-shaped form of Toxoplasma gondii, found in clusters enclosed by an irregular wall (pseudocyst) in the tissues, chiefly muscles and the brain, in chronic (latent) toxoplasmosis; considered to be the slow-growing form.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002342,,,,,,,BrendaTissueOBO,,BTO:0002342,,,,,,,,,,,,,,,,,,,bradyzoite,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000342,"[""THR315 in ABL1-phosphorylated""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000342,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR315 in ABL1-phosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400034,"[""Chemerin receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400034,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chemerin receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100064,"[""Cyclin-dependent kinase 18""]",,"A cyclin-dependent kinase 18 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q07002] |cyclin-dependent kinase 18 (PCTK3)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300256,,,,,,,,"A cyclin-dependent kinase 18 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q07002] |cyclin-dependent kinase 18 (PCTK3)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100064,,,,https://pharos.nih.gov/idg/targets/Q07002,,,,,,,,,,,,,CDK18,PCTAIRE3|PCTK3,,Q07002,,,,,,,,Cyclin-dependent kinase 18,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200227,"[""KCNK18 gene""]",,"Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains and the encoded protein functions as an outward rectifying potassium channel. A mutation in this gene has been found to be associated with migraine with aura.[provided by RefSeq, Jan 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400359,,,,,,,,"Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains and the encoded protein functions as an outward rectifying potassium channel. A mutation in this gene has been found to be associated with migraine with aura.[provided by RefSeq, Jan 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200227,,,,,,,,,,,,,,,,338567,KCNK18,TRESK|TRIK,,,,,,,,,,KCNK18 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000325,"[""THR315 in ABL1(E255K)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000325,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR315 in ABL1(E255K),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000785,"[""lymphoma cell""]",,A tumor cell of lymphoid tissue.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000580,,,,,,,,A tumor cell of lymphoid tissue.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000785,,,,,,,BrendaTissueOBO,lymph node cancer cell|lymphadenoma cell|lymph node carcinoma cell,BTO:0000785,,,,,,,,,,,,,,,,,,,lymphoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001926,"[""hybridoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001926,,,,,,,BrendaTissueOBO,,BTO:0001926,,,,,,,,,,,,,,,,,,,hybridoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100394,"[""Olfactory receptor 51f1""]",,"An olfactory receptor 51F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NGY5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 51F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NGY5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100394,,,,https://pharos.nih.gov/idg/targets/A6NGY5,,,,,,,,,,,,,OR51F1,OR51F1P,,A6NGY5,,,,,,,,Olfactory receptor 51f1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001367,"[""thigh muscle""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000722,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001367,,,,,,,BrendaTissueOBO,,BTO:0001367,,,,,,,,,,,,,,,,,,,thigh muscle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003119,"[""clitoral gland""]",,The preputial glands of female animals are sometimes called clitoral glands.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000254,,,,,,,,The preputial glands of female animals are sometimes called clitoral glands.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003119,,,,,,,BrendaTissueOBO,preputial gland of female,BTO:0003119,,,,,,,,,,,,,,,,,,,clitoral gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400327,"[""Ion channel gene""]",,"Ion channels are pore-forming membrane proteins whose functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane, controlling the flow of ions across secretory and epithelial cells, and regulating cell volume. Ion channels are present in the membranes of all cells.",false,,,http://www.drugtargetontology.org/dto/DTO_00200000,,,,,,,,"Ion channels are pore-forming membrane proteins whose functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane, controlling the flow of ions across secretory and epithelial cells, and regulating cell volume. Ion channels are present in the membranes of all cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,https://en.wikipedia.org/wiki/Ion_channel,Ion channel gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200023,"[""ALPK1 gene""]",,"This gene encodes an alpha kinase. Mice which were homozygous for disrupted copies of this gene exhibited coordination defects (PMID: 21208416). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400123,,,,,,,,"This gene encodes an alpha kinase. Mice which were homozygous for disrupted copies of this gene exhibited coordination defects (PMID: 21208416). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200023,,,,,,,,,,,,,,,,80216,ALPK1,KIAA1527|LAK,,,,,,,,,,ALPK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200056,"[""CACNG2 gene""]",,"The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400336,,,,,,,,"The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200056,,,,,,,,,,,,,,,,10369,CACNG2,,,,,,,,,,,CACNG2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100348,"[""Myosin light chain kinase 3""]",,"A myosin light chain kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q32MK0] |myosin light chain kinase 3 (MLCK)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300196,,,,,,,,"A myosin light chain kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q32MK0] |myosin light chain kinase 3 (MLCK)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100348,,,,https://pharos.nih.gov/idg/targets/Q32MK0,,,,,,,,,,,,,MYLK3,MLCK,,Q32MK0,,,,,,,,Myosin light chain kinase 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200124,"[""GABRR3 gene""]",,"The neurotransmitter gamma-aminobutyric acid (GABA) functions in the central nervous system to regulate synaptic transmission of neurons. This gene encodes one of three related subunits, which combine as homo- or hetero-pentamers to form GABA(C) receptors. In humans, some individuals contain a single-base polymorphism (dbSNP rs832032) that is predicted to inactivate the gene product. [provided by RefSeq, Jan 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400523,,,,,,,,"The neurotransmitter gamma-aminobutyric acid (GABA) functions in the central nervous system to regulate synaptic transmission of neurons. This gene encodes one of three related subunits, which combine as homo- or hetero-pentamers to form GABA(C) receptors. In humans, some individuals contain a single-base polymorphism (dbSNP rs832032) that is predicted to inactivate the gene product. [provided by RefSeq, Jan 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200124,,,,,,,,,,,,,,,,200959,GABRR3,,,,,,,,,,,GABRR3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200108,"[""FZD6 gene""]",,"A frizzled-6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60353] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400043,,,,,,,,"A frizzled-6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60353] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200108,,,,,,,,,,,,,,,,8323,FZD6,,,,,,,,,,,FZD6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100758,"[""RPE-retinal G protein-coupled receptor""]",,"An RPE-retinal G protein-coupled receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47804] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"An RPE-retinal G protein-coupled receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47804] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100758,,,,https://pharos.nih.gov/idg/targets/P47804,,,,,,,,,,,,,RGR,,,P47804,,,,,,,,RPE-retinal G protein-coupled receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100479,"[""Olfactory receptor 1B1""]",,"An olfactory receptor 1B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100479,,,,https://pharos.nih.gov/idg/targets/Q8NGR6,,,,,,,,,,,,,OR1B1,,,Q8NGR6,,,,,,,,Olfactory receptor 1B1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3390,"[""palmoplantar keratosis""]",,A keratosis characterized by abnormal thickening of the palms and the soles.,false,,,http://purl.obolibrary.org/obo/DOID_161,,,,,,,,A keratosis characterized by abnormal thickening of the palms and the soles.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3390,,,,NCI:C34748|SNOMEDCT_US_2016_03_01:706885006|SNOMEDCT_US_2016_03_01:205584004|ICD10CM:L85.2|MESH:D007645|SNOMEDCT_US_2016_03_01:28596004|UMLS_CUI:C0022596,Palmoplantar Keratoderma|Keratosis palmaris et plantaris,,disease_ontology,,DOID:3390,,,,,,,,,,,,,,,,,,,palmoplantar keratosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11465,"[""autonomic nervous system disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_574,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11465,,,,UMLS_CUI:C0154691|ICD9CM:337.1,autonomic nervous system disorder,,disease_ontology,,DOID:11465,,,,,,,,,,,,,,,,,,,autonomic nervous system disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000573,"[""artery""]",,Any of the tubular branching muscular- and elastic-walled vessels that carry blood from the heart through the body.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001102,,,,,,,,Any of the tubular branching muscular- and elastic-walled vessels that carry blood from the heart through the body.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000573,,,,,,,BrendaTissueOBO,arterial vessel,BTO:0000573,,,,,,,,,,,,,,,,,,,artery,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100484,"[""Olfactory receptor 1E1""]",,"An olfactory receptor 1E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30953] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30953] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100484,,,,https://pharos.nih.gov/idg/targets/P30953,,,,,,,,,,,,,OR1E1,OR1E5|OR1E6|OR1E9P,,P30953,,,,,,,,Olfactory receptor 1E1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003661,"[""ovary epithelium""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000416,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003661,,,,,,,BrendaTissueOBO,ovarian epithelium,BTO:0003661,,,,,,,,,,,,,,,,,,,ovary epithelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200041,"[""CACNA1D gene""]",,"Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400384,,,,,,,,"Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200041,,,,,,,,,,,,,,,,776,CACNA1D,CACH3|CACN4|CACNL1A2|CCHL1A2,,,,,,,,,,CACNA1D gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117459,"[""Dax-like receptors""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00102000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117459,,,,,,,,,,,,,,,,,,,,,,,,,,,,Dax-like receptors,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100258,"[""Mas-related g-protein coupled receptor member e""]",,"A mas-related G-protein coupled receptor E that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86SM8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300063,,,,,,,,"A mas-related G-protein coupled receptor E that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86SM8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100258,,,,https://pharos.nih.gov/idg/targets/Q86SM8,,,,,,,,,,,,,MRGPRE,GPR167|MRGE,,Q86SM8,,,,,,,,Mas-related g-protein coupled receptor member e,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003253,"[""ELT-3 cell""]",,Eker rat uterine leiomyoma-derived cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003252,,,,,,,,Eker rat uterine leiomyoma-derived cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003253,,,,,,,BrendaTissueOBO,ELT3 cell,BTO:0003253,,,,,,,,,,,,,,,,,,,ELT-3 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004282,"[""TSA cell""]",,TSA is an aggressive and poorly immunogenic cell line established from a moderately differentiated mammary adenocarcinoma that arose spontaneously in a multiparous BALB/c mouse.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001912,,,,,,,,TSA is an aggressive and poorly immunogenic cell line established from a moderately differentiated mammary adenocarcinoma that arose spontaneously in a multiparous BALB/c mouse.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004282,,,,,,,BrendaTissueOBO,,BTO:0004282,,,,,,,,,,,,,,,,,,,TSA cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002204,"[""palatine uvula""]",,The small cone-shaped process suspended in the mouth from the middle of the posterior border of the soft palate.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The small cone-shaped process suspended in the mouth from the middle of the posterior border of the soft palate.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002204,XPMUser,2013-02-28T04:12:45Z,,,,,BrendaTissueOBO,uvula|uvula palatina,BTO:0002204,,,,,,,,,,,,,,,,,,,palatine uvula,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100175,"[""Calcium-activated potassium channel subunit alpha-1""]",,"A calcium-activated potassium channel subunit alpha-1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q12791] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300531,,,,,,,,"A calcium-activated potassium channel subunit alpha-1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q12791] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100175,,,,https://pharos.nih.gov/idg/targets/Q12791,,,,,,,,,,,,,KCNMA1,KCNMA|SLO,,Q12791,,,,,,,,Calcium-activated potassium channel subunit alpha-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100336,"[""Dual specificity mitogen-activated protein kinase kinase 3""]",,"A dual specificity mitogen-activated protein kinase kinase 3 that is encoded in the genome of human. [TLR:AMM, UniProtKB:P46734] |dual specificity mitogen-activated protein kinase kinase 3 (MP2K3)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300194,,,,,,,,"A dual specificity mitogen-activated protein kinase kinase 3 that is encoded in the genome of human. [TLR:AMM, UniProtKB:P46734] |dual specificity mitogen-activated protein kinase kinase 3 (MP2K3)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100336,,,,https://pharos.nih.gov/idg/targets/P46734,,,,,,,,,,,,,MAP2K3,MEK3|MKK3|PRKMK3|SKK2,,P46734,,,,,,,,Dual specificity mitogen-activated protein kinase kinase 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2316,"[""brain ischemia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_326|http://purl.obolibrary.org/obo/DOID_936,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2316,,,,SNOMEDCT_US_2016_03_01:193049009|SNOMEDCT_US_2016_03_01:389100007|UMLS_CUI:C0007786|MESH:D002545|SNOMEDCT_US_2016_03_01:11890005,Ischemic encephalopathy (disorder)|Ischaemic encephalopathy,,disease_ontology,,DOID:2316,,,,,,,,,,,,,,,,,,,brain ischemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000022,"[""CXCL13""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000022,,,,,,,,,,,,,,,,,,,,,,,,,,,,CXCL13,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100714,"[""Olfactory receptor 9g1""]",,"An olfactory receptor 9G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH87] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 9G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH87] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100714,,,,https://pharos.nih.gov/idg/targets/Q8NH87,,,,,,,,,,,,,OR9G1,OR9G5,,Q8NH87,,,,,,,,Olfactory receptor 9g1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400437,"[""Calcium-activated subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400437,,,,,,,,,,,,,,,,,,,,,,,,,,,,Calcium-activated subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200377,"[""OXSR1 gene""]",,"The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400302,,,,,,,,"The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200377,,,,,,,,,,,,,,,,9943,OXSR1,KIAA1101|OSR1,,,,,,,,,,OXSR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000269,"[""colon""]",,The part of the large intestine that extends from the cecum to the rectum.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The part of the large intestine that extends from the cecum to the rectum.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000269,,,,,,,BrendaTissueOBO,,BTO:0000269,,,,,,,,,,,,,,,,,,,colon,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80201,"[""Neuropeptide Y""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG COMPOUND:C15949,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80201,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80201,,,,,Neuropeptide Y,,CHEBI:80201,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4931,"[""nasal cavity carcinoma""]",,A nasal cavity cancer that_has_material_basis_in epithelial cells.,false,,,http://purl.obolibrary.org/obo/DOID_10811|http://purl.obolibrary.org/obo/DOID_305,,,,,,,,A nasal cavity cancer that_has_material_basis_in epithelial cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4931,,,,NCI:C9336|UMLS_CUI:C1377785,cancer of nasal cavity,,disease_ontology,carcinoma of nasal cavity,DOID:4931,,,,,,,,,,,,,,,,,,,nasal cavity carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001240,"[""SF-9 cell""]",,"Insect - fall armyworm (Spodoptera frugiperda) cell line, cloned from the parent cell line, IPLB-SF-21-AE, derived from pupal ovarian tissue of the fall armyworm (species Spodoptera frugiperda, family Sciaridae, order Lepidoptera); cells are susceptible to infection with MNPV and other Baculoviruses; cells can be used with Baculovirus expression vectors. It was derived from SF-21.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Insect - fall armyworm (Spodoptera frugiperda) cell line, cloned from the parent cell line, IPLB-SF-21-AE, derived from pupal ovarian tissue of the fall armyworm (species Spodoptera frugiperda, family Sciaridae, order Lepidoptera); cells are susceptible to infection with MNPV and other Baculoviruses; cells can be used with Baculovirus expression vectors. It was derived from SF-21.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001240,,,,,,,BrendaTissueOBO,Sf9 cell,BTO:0001240,,,,,,,,,,,,,,,,,,,SF-9 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300470,"[""SCN4B family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300370,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300470,,,,,,,,,,,,,,,,,,,,,,,,,,,,SCN4B family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000164,"[""FLT3 kinase domain""]",,Fms-related tyrosine kinase 3; CD135; FLK2; FLK-2; FLT3; FLT-3; Ly72; STK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Fms-related tyrosine kinase 3; CD135; FLK2; FLK-2; FLT3; FLT-3; Ly72; STK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000164,,,,,,,,,,,,,,,,,,,200168,,,,,,,,,FLT3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03490993,"[""TBCK gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400232,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03490993,,,,,,,,,,,,,,,,,,,,,,,,,,,,TBCK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100295,"[""Olfactory receptor 10AD1""]",,"An olfactory receptor 10AD1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10AD1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100295,,,,https://pharos.nih.gov/idg/targets/Q8NGE0,,,,,,,,,,,,,OR10AD1,OR10AD1P,,Q8NGE0,,,,,,,,Olfactory receptor 10AD1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400508,"[""GABRA3 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400508,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRA3 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300062,"[""Kisspeptin receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300062,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kisspeptin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300447,"[""G subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300447,,,,,,,,,,,,,,,,,,,,,,,,,,,,G subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200389,"[""PAK7 gene""]",,"The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400304,,,,,,,,"The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200389,,,,,,,,,,,,,,,,57144,PAK7,KIAA1264|PAK5,,,,,,,,,,PAK7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00000006,"[""Tchem protein""]",,"Tchem are proteins that can specifically be manipulated with small molecules better than bioactivity cutoff values (30 nM for kinases, 100 nM for GPCRs and NRs, 10 uM for ICs, and 1 uM for other target classes), which lack approved small molecule or biologic drugs. In some cases, targets have been manually migrated to Tchem through human curation, based on small molecule activities from sources other than ChEMBL or Drug Central.",false,,,http://www.w3.org/2002/07/owl#Thing,,,,,,,,"Tchem are proteins that can specifically be manipulated with small molecules better than bioactivity cutoff values (30 nM for kinases, 100 nM for GPCRs and NRs, 10 uM for ICs, and 1 uM for other target classes), which lack approved small molecule or biologic drugs. In some cases, targets have been manually migrated to Tchem through human curation, based on small molecule activities from sources other than ChEMBL or Drug Central.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00000006,,,,,,,,,,,,,,,,,,,,,,,,,,,IDG; http://www.nature.com/nrd/posters/druggablegenome/nrd_druggablegenome.pdf,Tchem protein,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4624,"[""Ollier disease""]",,"A syndrome that is characterized by an asymmetric distribution of cartilagenous tumors, which may lead to skeletal deformities and limb-length discrepancy. This condition primarily affects the long bones and cartilage of the joints of the arms and legs, specifically the area where the shaft and head of a long bone meet.",false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,"A syndrome that is characterized by an asymmetric distribution of cartilagenous tumors, which may lead to skeletal deformities and limb-length discrepancy. This condition primarily affects the long bones and cartilage of the joints of the arms and legs, specifically the area where the shaft and head of a long bone meet.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4624,,,,NCI:C3213|MESH:D004687|SNOMEDCT_US_2016_03_01:205470006|SNOMEDCT_US_2016_03_01:46041001|SNOMEDCT_US_2016_03_01:234135008|ICD10CM:Q78.4|ORDO:296|OMIM:166000|UMLS_CUI:C0024454,"ENCHONDROMATOSIS, MULTIPLE|DYSCHONDROPLASIA|OSTEOCHONDROMATOSIS|Kast's syndrome|Enchondromatosis with haemangiomata",,disease_ontology,,DOID:4624,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Ollier disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005118,"[""RGC-5 cell""]",,Murine retinal ganglion cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0005117,,,,,,,,Murine retinal ganglion cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005118,XPMUser,2011-05-05T11:09:36Z,,,,,BrendaTissueOBO,,BTO:0005118,,,,,,,,,,,,,,,,,,,RGC-5 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200157,"[""GPR156 gene""]",,"A G-protein coupled receptor 156 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFN8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400045,,,,,,,,"A G-protein coupled receptor 156 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFN8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200157,,,,,,,,,,,,,,,,165829,GPR156,GABABL|PGR28,,,,,,,,,,GPR156 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100019,"[""Rac-alpha serine/threonine-protein kinase""]",,"A RAC-alpha serine/threonine-protein kinase that is encoded in the genome of human. [PRO:WCB, UniProtKB:P31749] |RAC-alpha serine/threonine-protein kinase (AKT1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300121,,,,,,,,"A RAC-alpha serine/threonine-protein kinase that is encoded in the genome of human. [PRO:WCB, UniProtKB:P31749] |RAC-alpha serine/threonine-protein kinase (AKT1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100019,,,,https://pharos.nih.gov/idg/targets/P31749,,,,,,,,,,,,,AKT1,PKB|RAC,,P31749,,,,,,,,Rac-alpha serine/threonine-protein kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117485,"[""Peroxisome proliferator-activated receptor alpha""]",,"A peroxisome proliferator-activated receptor alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q07869] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117462,,,,,,,,"A peroxisome proliferator-activated receptor alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q07869] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117485,,,,https://pharos.nih.gov/idg/targets/Q07869,,,,,,,,,,,,,PPARA,PPAR,,Q07869,,,,,,,,Peroxisome proliferator-activated receptor alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100441,"[""Olfactory receptor 56a5""]",,"An olfactory receptor 56A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7T3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 56A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7T3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100441,,,,https://pharos.nih.gov/idg/targets/P0C7T3,,,,,,,,,,,,,OR56A5,OR56A5P,,P0C7T3,,,,,,,,Olfactory receptor 56a5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000876,"[""monocyte""]",,"A mononuclear phagocytic leukocyte, 13 to 25 mm in diameter, with an ovoid or kidney-shaped nucleus, containing lacy, linear chromatin and abundant gray-blue cytoplasm filled with fine reddish and azurophilic granules. Formed in the bone marrow from promonocytes, monocytes are transported to tissues such as the lung and liver, where they develop into macrophages.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000751|http://purl.obolibrary.org/obo/BTO_0001433,,,,,,,,"A mononuclear phagocytic leukocyte, 13 to 25 mm in diameter, with an ovoid or kidney-shaped nucleus, containing lacy, linear chromatin and abundant gray-blue cytoplasm filled with fine reddish and azurophilic granules. Formed in the bone marrow from promonocytes, monocytes are transported to tissues such as the lung and liver, where they develop into macrophages.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000876,,,,,,,BrendaTissueOBO,nongranular leukocyte|mononuclear leukocyte,BTO:0000876,,,,,,,,,,,,,,,,,,,monocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100740,"[""Proteinase-activated receptor 4""]",,"A proteinase-activated receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96RI0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300079,,,,,,,,"A proteinase-activated receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96RI0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100740,,,,https://pharos.nih.gov/idg/targets/Q96RI0,,,,,,,,,,,,,F2RL3,PAR4,,Q96RI0,,,,,,,,Proteinase-activated receptor 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003954,"[""dopaminergic system""]",,The system of nerve cells that uses dopamine as its neurotransmitter.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The system of nerve cells that uses dopamine as its neurotransmitter.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003954,,,,,,,BrendaTissueOBO,,BTO:0003954,,,,,,,,,,,,,,,,,,,dopaminergic system,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_27485,"[""prostaglandin J2""]","9-Deoxy-delta-9-pgd2|UQOQENZZLBSFKO-POPPZSFYSA-N|InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1|PGJ2|C20H30O4|334.214|CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)C=CC1=O|9-Deoxy-delta-9-prostaglandin D2|334.44980|0","A member of the class of prostaglandins J that consists of prosta-5,9,13-trien-1-oic acid substituted by an oxo group at position 11 and a hydroxy group at position 15 (the 5Z,13E,15S stereoisomer).",false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,HMDB:HMDB02710|PMID:12213491|Reaxys:8353080|LIPID_MAPS_instance:LMFA03010019|CAS:60203-57-8|KEGG:C05957,"A member of the class of prostaglandins J that consists of prosta-5,9,13-trien-1-oic acid substituted by an oxo group at position 11 and a hydroxy group at position 15 (the 5Z,13E,15S stereoisomer).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:26332|CHEBI:8521,,"(5Z,13E,15S)-15-hydroxy-11-oxoprosta-5,9,13-trien-1-oic acid|Prostaglandin J2",,chebi_ontology,"9-Deoxy-delta-9-pgd2|UQOQENZZLBSFKO-POPPZSFYSA-N|InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1|PGJ2|C20H30O4|334.214|CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)C=CC1=O|9-Deoxy-delta-9-prostaglandin D2|334.44980|0",,,CHEBI:27485,,,,,,,,,,,,,,,,,,,,,,,CHEBI:27485,,,,,prostaglandin J2,,CHEBI:27485,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200481,"[""SPEG gene""]",,"This gene encodes a protein with similarity to members of the myosin light chain kinase family. This protein family is required for myocyte cytoskeletal development. Studies in mouse have determined that a lack of this protein affected myocardial development. Multiple alternatively spliced transcript variants have been reported for this gene, but the full-length nature of only two variants that encode different protein isoforms has been defined. [provided by RefSeq, Mar 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400168,,,,,,,,"This gene encodes a protein with similarity to members of the myosin light chain kinase family. This protein family is required for myocyte cytoskeletal development. Studies in mouse have determined that a lack of this protein affected myocardial development. Multiple alternatively spliced transcript variants have been reported for this gene, but the full-length nature of only two variants that encode different protein isoforms has been defined. [provided by RefSeq, Mar 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200481,,,,,,,,,,,,,,,,10290,SPEG,APEG1|KIAA1297,,,,,,,,,,SPEG gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003316,"[""JB6 Cl41 cell""]",,Human colorectal cancer cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001616,,,,,,,,Human colorectal cancer cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003316,,,,,,,BrendaTissueOBO,JB6 clone 41 cell|JB6Cl41 cell,BTO:0003316,,,,,,,,,,,,,,,,,,,JB6 Cl41 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002626,"[""venule""]",,"A small vein, especially one joining capillaries to larger veins.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000234,,,,,,,,"A small vein, especially one joining capillaries to larger veins.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002626,,,,,,,BrendaTissueOBO,,BTO:0002626,,,,,,,,,,,,,,,,,,,venule,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002719,"[""primary effusion lymphoma cell line""]",,"Primary effusion lymphoma (PEL) is a peculiar type of B cell non-Hodgkin lymphoma (NHL) that has been recently recognized as an individual clinico-pathologic category based on the consistent infection of the tumor clone by human herpesvirus type-8 (HHV-8) and the distinctiveness of its clinical and biologic features. Although immunogenotypic studies have confirmed that PEL belongs in all cases to the B cell lineage, the overwhelming majority of cases exhibit a non-B, non-T (ie indeterminate) phenotype, lacking expression of surface immunoglobulins and common B cell associated antigens.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001518,,,,,,,,"Primary effusion lymphoma (PEL) is a peculiar type of B cell non-Hodgkin lymphoma (NHL) that has been recently recognized as an individual clinico-pathologic category based on the consistent infection of the tumor clone by human herpesvirus type-8 (HHV-8) and the distinctiveness of its clinical and biologic features. Although immunogenotypic studies have confirmed that PEL belongs in all cases to the B cell lineage, the overwhelming majority of cases exhibit a non-B, non-T (ie indeterminate) phenotype, lacking expression of surface immunoglobulins and common B cell associated antigens.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002719,,,,,,,BrendaTissueOBO,PEL cell line|BCBL cell|body cavity-based lymphoma cell|body cavity based lymphoma cell line,BTO:0002719,,,,,,,,,,,,,,,,,,,primary effusion lymphoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100292,"[""Sodium channel subunit beta-2""]",,"A sodium channel subunit beta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60939] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300466,,,,,,,,"A sodium channel subunit beta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60939] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100292,,,,https://pharos.nih.gov/idg/targets/O60939,,,,,,,,,,,,,SCN2B,,,O60939,,,,,,,,Sodium channel subunit beta-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117473,"[""Estrogen-related receptors""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00102000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117473,,,,,,,,,,,,,,,,,,,,,,,,,,,,Estrogen-related receptors,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300478,"[""SCNN1B subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300330,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300478,,,,,,,,,,,,,,,,,,,,,,,,,,,,SCNN1B subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000858,"[""mesophyll""]",,The photosynthetic parenchyma between the epidermal layers of a foliage leaf.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The photosynthetic parenchyma between the epidermal layers of a foliage leaf.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000858,,,,,,,BrendaTissueOBO,,BTO:0000858,,,,,,,,,,,,,,,,,,,mesophyll,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100694,"[""Olfactory receptor 8G1""]",,"An olfactory receptor 8G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15617] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 8G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15617] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100694,,,,https://pharos.nih.gov/idg/targets/Q15617,,,,,,,,,,,,,OR8G1,OR8G1P,,Q15617,,,,,,,,Olfactory receptor 8G1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100054,"[""Cyclin-dependent kinase 11a""]",,"A cyclin-dependent kinase 11A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UQ88] |cyclin-dependent kinase 11a (CDC2L2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300254,,,,,,,,"A cyclin-dependent kinase 11A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UQ88] |cyclin-dependent kinase 11a (CDC2L2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100054,,,,https://pharos.nih.gov/idg/targets/Q9UQ88,,,,,,,,,,,,,CDK11A,CDC2L2|CDC2L3|PITSLREB,,Q9UQ88,,,,,,,,Cyclin-dependent kinase 11a,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13282,"[""intestinal tuberculosis""]",,"A gastrointestinal tuberculosis that involves diffuse mucosal fold thickening, formation of ulcers and fistulae located_in intestine. The infection has_symptom abdominal pain, has_symptom gastrointestinal bleeding, has_symptom nausea and has_symptom vomiting.",false,,,http://purl.obolibrary.org/obo/DOID_404,,,,,,,,"A gastrointestinal tuberculosis that involves diffuse mucosal fold thickening, formation of ulcers and fistulae located_in intestine. The infection has_symptom abdominal pain, has_symptom gastrointestinal bleeding, has_symptom nausea and has_symptom vomiting.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13282,,,,ICD9CM:014.8|UMLS_CUI:C0152724,tuberculosis of intestine,,disease_ontology,,DOID:13282,http://purl.obolibrary.org/obo/doid#gram-positive_bacterial_infectious_disease,,,,,,,,,,,,,,,,,,intestinal tuberculosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300531,"[""KCa1.1/KCNMA1 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300437,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300531,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCa1.1/KCNMA1 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100572,"[""Olfactory receptor 4c11""]",,"An olfactory receptor 4C11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IEV9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4C11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IEV9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100572,,,,https://pharos.nih.gov/idg/targets/Q6IEV9,,,,,,,,,,,,,OR4C11,OR4C11P,,Q6IEV9,,,,,,,,Olfactory receptor 4c11,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000169,"[""FLT3(N841I) kinase domain""]",,Fms-related tyrosine kinase 3; CD135; FLK2; FLK-2; FLT3; FLT-3; Ly72; STK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Fms-related tyrosine kinase 3; CD135; FLK2; FLK-2; FLT3; FLT-3; Ly72; STK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000169,,,,,,,,,,,,,,,,,,,200173,,,,,,,,,FLT3(N841I) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0080053,"[""Albright's hereditary osteodystrophy""]",,"An osteochondrodysplasia that has_material_basis_in lack of responsiveness to parathyroid hormone which results_in shortening and widening of long bones of the located_in hand or located_in foot along with short stature, obesity, and rounded face.",false,,,http://purl.obolibrary.org/obo/DOID_4184,,,,,,,,"An osteochondrodysplasia that has_material_basis_in lack of responsiveness to parathyroid hormone which results_in shortening and widening of long bones of the located_in hand or located_in foot along with short stature, obesity, and rounded face.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0080053,,,,OMIM:103580,pseudohypoparathyroidism type 1a|Albright hereditary osteodystrophy,,disease_ontology,,DOID:0080053,,,,,,,,,,,,,,,,,,,Albright's hereditary osteodystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000016,"[""CCL25""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000016,,,,,,,,,,,,,,,,,,,,,,,,,,,,CCL25,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100036,"[""Voltage-dependent calcium channel subunit alpha-2/delta-3""]",,"A voltage-dependent calcium channel subunit alpha-2/delta-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZS8] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300332,,,,,,,,"A voltage-dependent calcium channel subunit alpha-2/delta-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZS8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100036,,,,https://pharos.nih.gov/idg/targets/Q8IZS8,,,,,,,,,,,,,CACNA2D3,,,Q8IZS8,,,,,,,,Voltage-dependent calcium channel subunit alpha-2/delta-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100341,"[""Olfactory receptor 13C3""]",,"An olfactory receptor 13C3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 13C3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100341,,,,https://pharos.nih.gov/idg/targets/Q8NGS6,,,,,,,,,,,,,OR13C3,,,Q8NGS6,,,,,,,,Olfactory receptor 13C3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_7997,"[""thyrotoxicosis""]",,A thyroid gland disease that is characterized by excess thyroid hormone.,false,,,http://purl.obolibrary.org/obo/DOID_50,,,,,,,,A thyroid gland disease that is characterized by excess thyroid hormone.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:7997,,,,ICD10CM:E05.9|SNOMEDCT_US_2016_03_01:286909009|ICD9CM:242|UMLS_CUI:C0040156|SNOMEDCT_US_2016_03_01:190239004|SNOMEDCT_US_2016_03_01:267464006|SNOMEDCT_US_2016_03_01:267373004|SNOMEDCT_US_2016_03_01:90739004|SNOMEDCT_US_2016_03_01:190267008|SNOMEDCT_US_2016_03_01:154655004|OMIM:275000|NCI:C61469|MESH:D013971|SNOMEDCT_US_2016_03_01:154659005,,,disease_ontology,,DOID:7997,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,thyrotoxicosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100532,"[""Olfactory receptor 2J3""]",,"An olfactory receptor 2J3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76001] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2J3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76001] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100532,,,,https://pharos.nih.gov/idg/targets/O76001,,,,,,,,,,,,,OR2J3,,,O76001,,,,,,,,Olfactory receptor 2J3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200430,"[""PLK1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400211,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200430,,,,,,,,,,,,,,,,5347,PLK1,PLK,,,,,,,,,,PLK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200427,"[""PKN1 gene""]",,"The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400210,,,,,,,,"The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200427,,,,,,,,,,,,,,,,5585,PKN1,PAK1|PKN|PRK1,,,,,,,,,,PKN1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050913,"[""large intestine adenocarcinoma""]",,A large intestine cancer that has_material_basis_in epithelial cells of glandular origin.,false,,,http://purl.obolibrary.org/obo/DOID_5672|http://purl.obolibrary.org/obo/DOID_299,,,,,,,,A large intestine cancer that has_material_basis_in epithelial cells of glandular origin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050913,lschriml,2014-10-13T15:00:10Z,,,,,disease_ontology,,DOID:0050913,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,large intestine adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300492,"[""Alpha-3/CHRNA3 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300492,,,,,,,,,,,,,,,,,,,,,,,,,,,,Alpha-3/CHRNA3 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100044,"[""Bombesin receptor subtype-3""]",,"A bombesin receptor subtype-3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32247] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300026,,,,,,,,"A bombesin receptor subtype-3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32247] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100044,,,,https://pharos.nih.gov/idg/targets/P32247,,,,,,,,,,,,,BRS3,,,P32247,,,,,,,,Bombesin receptor subtype-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8997,"[""polycythemia vera""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_8432,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8997,,,,NCI:C3336|OMIM:263300|ICD9CM:238.4|SNOMEDCT_US_2016_03_01:31569001|MESH:D011087|SNOMEDCT_US_2016_03_01:128841001|SNOMEDCT_US_2016_03_01:278190000|SNOMEDCT_US_2016_03_01:154644004|SNOMEDCT_US_2016_03_01:269652000|SNOMEDCT_US_2016_03_01:109992005|ICD10CM:D45|UMLS_CUI:C0032463|SNOMEDCT_US_2016_03_01:134182002,Proliferative polycythaemia|Polycythaemia rubra vera|Osler-Vaquez syndrome,,disease_ontology,,DOID:8997,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,polycythemia vera,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100135,"[""Glutamate receptor 3""]",,"A glutamate receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42263] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300412,,,,,,,,"A glutamate receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42263] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100135,,,,https://pharos.nih.gov/idg/targets/P42263,,,,,,,,,,,,,GRIA3,GLUR3|GLURC,,P42263,,,,,,,,Glutamate receptor 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200515,"[""TAOK2 gene""]",,"This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400318,,,,,,,,"This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200515,,,,,,,,,,,,,,,,9344,TAOK2,KIAA0881|MAP3K17|PSK,,,,,,,,,,TAOK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001249,"[""silique""]",,"A narrow elongated two-valved usually many-seeded capsule that is characteristic of the mustard family, opens by sutures at either margin, and has two parietal placentas.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000173,,,,,,,,"A narrow elongated two-valved usually many-seeded capsule that is characteristic of the mustard family, opens by sutures at either margin, and has two parietal placentas.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001249,,,,,,,BrendaTissueOBO,,BTO:0001249,,,,,,,,,,,,,,,,,,,silique,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10095,"[""intracranial abscess""]",,A central nervous system disease that is located_in the skull and is characterized by a collection of pus (infected material) inside the skull.,false,,,http://purl.obolibrary.org/obo/DOID_331,,,,,,,,A central nervous system disease that is located_in the skull and is characterized by a collection of pus (infected material) inside the skull.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10095,,,,ICD9CM:324.0|SNOMEDCT_US_2016_03_01:192738001|SNOMEDCT_US_2016_03_01:192746000|SNOMEDCT_US_2016_03_01:27614006|UMLS_CUI:C0021874|NCI:C34734,,,disease_ontology,,DOID:10095,,,,,,,,,,,,,,,,,,,intracranial abscess,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100329,"[""Map kinase-interacting serine/threonine-protein kinase 2""]",,"MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2)  with  no mutation  in a nonphosphorylated state|A MAP kinase-interacting serine/threonine-protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HBH9] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300296,,,,,,,,"MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2)  with  no mutation  in a nonphosphorylated state|A MAP kinase-interacting serine/threonine-protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HBH9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100329,,,,https://pharos.nih.gov/idg/targets/Q9HBH9,,,,,,,,,,,,,MKNK2,GPRK7|MNK2,,Q9HBH9,,,,,,,,Map kinase-interacting serine/threonine-protein kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100078,"[""H(+)/Cl(-) exchange transporter 7""]",,"An H(+)/Cl(-) exchange transporter 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51798] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300401,,,,,,,,"An H(+)/Cl(-) exchange transporter 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51798] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100078,,,,https://pharos.nih.gov/idg/targets/P51798,,,,,,,,,,,,,CLCN7,,,P51798,,,,,,,,H(+)/Cl(-) exchange transporter 7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100263,"[""Thymidylate kinase""]",,"A thymidylate kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23919] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391018,,,,,,,,"A thymidylate kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23919] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100263,,,,https://pharos.nih.gov/idg/targets/P23919,,,,,,,,,,,,,DTYMK,CDC8|TMPK|TYMK,,P23919,,,,,,,,Thymidylate kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000038,"[""LEU118 in KC1G1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000038,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU118 in KC1G1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200546,"[""OR2T2 gene""]",,"An olfactory receptor 2T2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF00] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2T2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF00] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200546,,,,,,,,,,,,,,,,401992,OR2T2,OR2T2P,,,,,,,,,,OR2T2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001359,"[""medulloblastoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000711|http://purl.obolibrary.org/obo/BTO_0000690,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001359,,,,,,,BrendaTissueOBO,,BTO:0001359,,,,,,,,,,,,,,,,,,,medulloblastoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001101,"[""pons""]",,A broad mass of chiefly transverse nerve fibers conspicuous on the ventral surface of the brain of man and lower mammals at the anterior end of the medulla oblongata.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A broad mass of chiefly transverse nerve fibers conspicuous on the ventral surface of the brain of man and lower mammals at the anterior end of the medulla oblongata.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001101,,,,,,,BrendaTissueOBO,,BTO:0001101,,,,,,,,,,,,,,,,,,,pons,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200470,"[""SGK494 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400223,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200470,,,,,,,,,,,,,,,,124923,SGK494,,,,,,,,,,,SGK494 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100141,"[""Receptor tyrosine-protein kinase erbb-4""]",,"A receptor tyrosine-protein kinase erbB-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15303] |receptor tyrosine-protein kinase erbb-4 (ERBB4)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300152,,,,,,,,"A receptor tyrosine-protein kinase erbB-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15303] |receptor tyrosine-protein kinase erbb-4 (ERBB4)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100141,,,,https://pharos.nih.gov/idg/targets/Q15303,,,,,,,,,,,,,ERBB4,HER4,,Q15303,,,,,,,,Receptor tyrosine-protein kinase erbb-4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000409,"[""THR82 in MLTK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000409,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR82 in MLTK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200309,"[""MAST4 gene""]",,"This gene encodes a member of the microtubule-associated serine/threonine protein kinases. The proteins in this family contain a domain that gives the kinase the ability to determine its own scaffold to control the effects of their kinase activities. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400160,,,,,,,,"This gene encodes a member of the microtubule-associated serine/threonine protein kinases. The proteins in this family contain a domain that gives the kinase the ability to determine its own scaffold to control the effects of their kinase activities. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200309,,,,,,,,,,,,,,,,375449,MAST4,KIAA0303,,,,,,,,,,MAST4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060390,"[""distal 10q deletion syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060388,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060390,elvira,2015-09-28T16:08:42Z,,MESH:C567182|OMIM:609625|ORDO:96148|ICD10CM:Q93.5,telomeric deletion 10q|chromosome 10q26 deletion syndrome|distal monosomy 10q|terminal chromosome 10q26 deletion syndrome|monosomy 10qter,,disease_ontology,,DOID:0060390,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,distal 10q deletion syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060394,"[""chromosome 15q13.3 microdeletion syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060388,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060394,elvira,2015-09-28T16:23:21Z,,OMIM:612001|ORDO:199318|MESH:C567439|ICD10CM:Q93.5,15q13.3 microdeletion syndrome,,disease_ontology,,DOID:0060394,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,chromosome 15q13.3 microdeletion syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060391,"[""chromosome 13q14 deletion syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060388,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060391,elvira,2015-09-28T16:14:46Z,,OMIM:613884|ICD10CM:Q93.5|ORDO:1587,deletion 13q14,,disease_ontology,,DOID:0060391,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,chromosome 13q14 deletion syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491001,"[""AK1 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491014,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491001,,,,,,,,,,,,,,,,,,,,,,,,,,,,AK1 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400558,"[""Kv11.2/KCNH6 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400448,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400558,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv11.2/KCNH6 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000357,"[""THR474 in BTK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000357,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR474 in BTK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200362,"[""NEK8 gene""]",,"This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400197,,,,,,,,"This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200362,,,,,,,,,,,,,,,,284086,NEK8,JCK|NEK12A,,,,,,,,,,NEK8 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100052,"[""S752-I759del in EGFR(S752-I759del)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100052,,,,,,,,,,,,,,,,,,,,,,,,,,,,S752-I759del in EGFR(S752-I759del),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200138,"[""EPHB6 gene""]",,"This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400153,,,,,,,,"This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200138,,,,,,,,,,,,,,,,2051,EPHB6,,,,,,,,,,,EPHB6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2742,"[""auditory system disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0050155,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2742,,,DOID:1490|DOID:2011,SNOMEDCT_US_2016_03_01:155253008|SNOMEDCT_US_2016_03_01:267768008|NCI:C26757|SNOMEDCT_US_2016_03_01:25906001|SNOMEDCT_US_2016_03_01:194193002|UMLS_CUI:C0013447|ICD10CM:H93.9|SNOMEDCT_US_2016_03_01:155261003|ICD10CM:H93.90|ICD9CM:388.9|MESH:D004427|SNOMEDCT_US_2016_03_01:194410006,ear and mastoid disease,,disease_ontology,,DOID:2742,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,auditory system disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001255,"[""skin fibroblast""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000452,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001255,,,,,,,BrendaTissueOBO,,BTO:0001255,,,,,,,,,,,,,,,,,,,skin fibroblast,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300450,"[""S subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300450,,,,,,,,,,,,,,,,,,,,,,,,,,,,S subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200017,"[""ADCK5 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400247,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200017,,,,,,,,,,,,,,,,203054,ADCK5,,,,,,,,,,,ADCK5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000257,"[""MAP4K4 kinase domain""]",,Mitogen-activated protein kinase kinase kinase kinase 4; FLH21957; FLJ10410; FLJ20373; FLJ90111; HGK; HGK/ZC1; KIAA0687; MAP4K4; NIK; ZC1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase kinase kinase kinase 4; FLH21957; FLJ10410; FLJ20373; FLJ90111; HGK; HGK/ZC1; KIAA0687; MAP4K4; NIK; ZC1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000257,,,,,,,,,,,,,,,,,,,200242,,,,,,,,,MAP4K4 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004178,"[""leukemic stem cell""]",,"A normal stem or progenitor cell undergoes a mutation, giving rise to an entity that is functionally defined as a leukemic stem cell. The mutated stem cells differentiate into the hematopoietic lineage carrying the defect/s or can remain as immature progenitor cells, the blast cells.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0004254,,,,,,,,"A normal stem or progenitor cell undergoes a mutation, giving rise to an entity that is functionally defined as a leukemic stem cell. The mutated stem cells differentiate into the hematopoietic lineage carrying the defect/s or can remain as immature progenitor cells, the blast cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004178,,,,,,,BrendaTissueOBO,LSC cell,BTO:0004178,,,,,,,,,,,,,,,,,,,leukemic stem cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400415,"[""GRID2 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400415,,,,,,,,,,,,,,,,,,,,,,,,,,,,GRID2 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000498,"[""gastric cancer cell""]",,Gastric cancer is a cancer of the stomach.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Gastric cancer is a cancer of the stomach.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000498,,,,,,,BrendaTissueOBO,stomach cancer cell|stomach carcinoma cell,BTO:0000498,,,,,,,,,,,,,,,,,,,gastric cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100157,"[""Probable G-protein coupled receptor 156""]",,"A G-protein coupled receptor 156 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFN8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300045,,,,,,,,"A G-protein coupled receptor 156 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFN8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100157,,,,https://pharos.nih.gov/idg/targets/Q8NFN8,,,,,,,,,,,,,GPR156,GABABL|PGR28,,Q8NFN8,,,,,,,,Probable G-protein coupled receptor 156,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100251,"[""Mucolipin-3""]",,"A mucolipin-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TDD5] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300576,,,,,,,,"A mucolipin-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TDD5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100251,,,,https://pharos.nih.gov/idg/targets/Q8TDD5,,,,,,,,,,,,,MCOLN3,,,Q8TDD5,,,,,,,,Mucolipin-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100254,"[""Ribosomal protein s6 kinase alpha-4""]",,"ribosomal protein s6 kinase alpha-4 (RPS6KA4(Kin.Dom.1-N-terminal))  with  no mutation  in a nonphosphorylated state|A ribosomal protein S6 kinase alpha-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75676] |ribosomal protein s6 kinase alpha-4 (RPS6KA4(Kin.Dom.2-C-terminal))  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300281,,,,,,,,"ribosomal protein s6 kinase alpha-4 (RPS6KA4(Kin.Dom.1-N-terminal))  with  no mutation  in a nonphosphorylated state|A ribosomal protein S6 kinase alpha-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75676] |ribosomal protein s6 kinase alpha-4 (RPS6KA4(Kin.Dom.2-C-terminal))  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100254,,,,https://pharos.nih.gov/idg/targets/O75676,,,,,,,,,,,,,RPS6KA4,MSK2,,O75676,,,,,,,,Ribosomal protein s6 kinase alpha-4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300050,"[""Gonadotrophin-releasing hormone receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300050,,,,,,,,,,,,,,,,,,,,,,,,,,,,Gonadotrophin-releasing hormone receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3210,"[""Pelizaeus-Merzbacher disease""]",,"A hypomyelinating leukodystrophy characterized by impaired myelin formation, nystagmus, spastic quadriplegia, ataxia, and developmental delay that has_material_basis_in mutation in the PLP1 gene on chromosome Xq22.",false,,,http://purl.obolibrary.org/obo/DOID_0060786,,,,,,,,"A hypomyelinating leukodystrophy characterized by impaired myelin formation, nystagmus, spastic quadriplegia, ataxia, and developmental delay that has_material_basis_in mutation in the PLP1 gene on chromosome Xq22.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3210,,,,ICD10CM:E75.2|ORDO:702|NCI:C75487|MESH:D020371|OMIM:312080|SNOMEDCT_US_2016_03_01:64855000|UMLS_CUI:C0205711,"diffuse familial brain sclerosis|sudanophilic leukodystrophy, Paelizeus-Merzbacher type|hypomyelinating leukodystrophy 1|Pelizaeus-Merzbacher brain sclerosis|HLD1|PMD|Leukodystrophy, sudanophilic|Pelizaeus Merzbacher brain sclerosis",,disease_ontology,,DOID:3210,,,,,,,,,,,,,,,,,,,Pelizaeus-Merzbacher disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1752,"[""ocular melanoma""]",,An ocular cancer that has_material_basis_in melanocytes and is located_in the eye.,false,,,http://purl.obolibrary.org/obo/DOID_5614|http://purl.obolibrary.org/obo/DOID_1909|http://purl.obolibrary.org/obo/DOID_2174,,,,,,,,An ocular cancer that has_material_basis_in melanocytes and is located_in the eye.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1752,,,,,intraocular melanoma|eye melanoma|melanoma of eye,,disease_ontology,,DOID:1752,,,,,,,,,,,,,,,,,,,ocular melanoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100347,"[""Olfactory receptor 13f1""]",,"An olfactory receptor 13F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 13F1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100347,,,,https://pharos.nih.gov/idg/targets/Q8NGS4,,,,,,,,,,,,,OR13F1,,,Q8NGS4,,,,,,,,Olfactory receptor 13f1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000141,"[""MET178 in MP2K4""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000141,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET178 in MP2K4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100053,"[""Cam kinase-like vesicle-associated protein""]",,"A CaM kinase-like vesicle-associated protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NCB2] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300135,,,,,,,,"A CaM kinase-like vesicle-associated protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NCB2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100053,,,,https://pharos.nih.gov/idg/targets/Q8NCB2,,,,,,,,,,,,,CAMKV,,,Q8NCB2,,,,,,,,Cam kinase-like vesicle-associated protein,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100665,"[""Olfactory receptor 6n1""]",,"An olfactory receptor 6N1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6N1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100665,,,,https://pharos.nih.gov/idg/targets/Q8NGY5,,,,,,,,,,,,,OR6N1,,,Q8NGY5,,,,,,,,Olfactory receptor 6n1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000229,"[""KPCI kinase domain""]",,"Protein kinase C, iota; DXS1179E; MGC26534; nPKC-iota; PKCI; PRKCI",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Protein kinase C, iota; DXS1179E; MGC26534; nPKC-iota; PKCI; PRKCI",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000229,,,,,,,,,,,,,,,,,,,200357,,,,,,,,,KPCI kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200241,"[""KCNT2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400570,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200241,,,,,,,,,,,,,,,,343450,KCNT2,SLICK,,,,,,,,,,KCNT2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000352,"[""PIK3CD kinase domain""]",,"Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta; p110D; P110DELTA; PI3K; PIK3CD; PI3K-delta",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta; p110D; P110DELTA; PI3K; PIK3CD; PI3K-delta",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000352,,,,,,,,,,,,,,,,,,,200334,,,,,,,,,PIK3CD kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400195,"[""MUSK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400195,,,,,,,,,,,,,,,,,,,,,,,,,,,,MUSK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004911,"[""erythroid progenitor cell""]",,"Committed, erythroid stem cells derived from myeloid stem cells. The progenitor cells develop in two phases: erythroid burst-forming units (bfu-e) followed by erythroid colony-forming units (cfu-e). Bfu-e differentiate into cfu-e on stimulation by erythropoietin, and then further differentiate into erythroblasts when stimulated by other factors.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Committed, erythroid stem cells derived from myeloid stem cells. The progenitor cells develop in two phases: erythroid burst-forming units (bfu-e) followed by erythroid colony-forming units (cfu-e). Bfu-e differentiate into cfu-e on stimulation by erythropoietin, and then further differentiate into erythroblasts when stimulated by other factors.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004911,marion,2010-10-25T05:15:19Z,,,,,BrendaTissueOBO,,BTO:0004911,,,,,,,,,,,,,,,,,,,erythroid progenitor cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100518,"[""Olfactory receptor 2C1""]",,"An olfactory receptor 2C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95371] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95371] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100518,,,,https://pharos.nih.gov/idg/targets/O95371,,,,,,,,,,,,,OR2C1,OR2C2P,,O95371,,,,,,,,Olfactory receptor 2C1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100038,"[""Apelin receptor""]",,"An apelin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35414] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300024,,,,,,,,"An apelin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35414] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100038,,,,https://pharos.nih.gov/idg/targets/P35414,,,,,,,,,,,,,APLNR,AGTRL1|APJ,,P35414,,,,,,,,Apelin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001847,"[""umbilical smooth muscle""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001415|http://purl.obolibrary.org/obo/BTO_0001260,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001847,,,,,,,BrendaTissueOBO,,BTO:0001847,,,,,,,,,,,,,,,,,,,umbilical smooth muscle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300285,"[""LZK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300165,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300285,,,,,,,,,,,,,,,,,,,,,,,,,,,,LZK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200117,"[""GALR3 gene""]",,"A galanin receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O60755] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400046,,,,,,,,"A galanin receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O60755] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200117,,,,,,,,,,,,,,,,8484,GALR3,GALNR3,,,,,,,,,,GALR3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000536,"[""gracilis muscle""]",,"The Gracilis is the most superficial muscle on the medial side of the thigh. It is thin and flattened, broad above, narrow and tapering below. It arises by a thin aponeurosis from the anterior margins of the lower half of the symphysis pubis and the upper half of the pubic arch. The fibers run vertically downward, and end in a rounded tendon, which passes behind the medial condyle of the femur, curves around the medial condyle of the tibia, where it becomes flattened, and is inserted into the upper part of the medial surface of the body of the tibia, below the condyle.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001367,,,,,,,,"The Gracilis is the most superficial muscle on the medial side of the thigh. It is thin and flattened, broad above, narrow and tapering below. It arises by a thin aponeurosis from the anterior margins of the lower half of the symphysis pubis and the upper half of the pubic arch. The fibers run vertically downward, and end in a rounded tendon, which passes behind the medial condyle of the femur, curves around the medial condyle of the tibia, where it becomes flattened, and is inserted into the upper part of the medial surface of the body of the tibia, below the condyle.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000536,,,,,,,BrendaTissueOBO,gracilis,BTO:0000536,,,,,,,,,,,,,,,,,,,gracilis muscle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100610,"[""Olfactory receptor 4X2""]",,"An olfactory receptor 4X2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4X2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100610,,,,https://pharos.nih.gov/idg/targets/Q8NGF9,,,,,,,,,,,,,OR4X2,,,Q8NGF9,,,,,,,,Olfactory receptor 4X2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3490,"[""Noonan syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3490,,,,OMIM:PS163950|ORDO:648|UMLS_CUI:C0028326|NCI:C34854|NCI:C75459|MESH:D009634|SNOMEDCT_US_2016_03_01:88327006|ICD10CM:Q87.1|SNOMEDCT_US_2016_03_01:205794007|SNOMEDCT_US_2016_03_01:205684007|SNOMEDCT_US_2016_03_01:205824006,"Turner's phenotype, karyotype normal (disorder)",,disease_ontology,,DOID:3490,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Noonan syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000406,"[""L-428 cell""]",,"Human Hodgkin's lymphoma, established from the pleural effusion of a 37-year-old woman with Hodgkin's lymphoma (stage IVB, nodular sclerosis, refractory, terminal) in 1978.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0004973,,,,,,,,"Human Hodgkin's lymphoma, established from the pleural effusion of a 37-year-old woman with Hodgkin's lymphoma (stage IVB, nodular sclerosis, refractory, terminal) in 1978.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000406,,,,,,,BrendaTissueOBO,L428 cell,BTO:0000406,,,,,,,,,,,,,,,,,,,L-428 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000755,"[""Leydig cell""]",,"Interstitial cells of the testis, which secrete testosterone.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0004238,,,,,,,,"Interstitial cells of the testis, which secrete testosterone.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000755,,,,,,,BrendaTissueOBO,interstitial cells of Leydig,BTO:0000755,,,,,,,,,,,,,,,,,,,Leydig cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001583,"[""T-98G cell""]",,"Human brain glioblastoma multiforme cell line, established from a 61 years old caucasian male.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001530,,,,,,,,"Human brain glioblastoma multiforme cell line, established from a 61 years old caucasian male.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001583,,,,,,,BrendaTissueOBO,T98 cell|T98G cell|T-98 cell,BTO:0001583,,,,,,,,,,,,,,,,,,,T-98G cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100428,"[""Putative olfactory receptor 52l2""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100428,,,,https://pharos.nih.gov/idg/targets/Q8NGH6,,,,,,,,,,,,,OR52L2P,OR52L2,,Q8NGH6,,,,,,,,Putative olfactory receptor 52l2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400282,"[""P70 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400178,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400282,,,,,,,,,,,,,,,,,,,,,,,,,,,,P70 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391041,"[""Unclassified protein""]",,A probable kinase protein that is not yet classified into either protein kinase or non-protein kinase.,false,,,http://www.drugtargetontology.org/dto/DTO_03300101,,,,,,,,A probable kinase protein that is not yet classified into either protein kinase or non-protein kinase.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,Unclassified protein,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060668,"[""anencephaly""]",,"A congenital nervous system abnormality characterized by failure of the anterior neuropore to close resulting in partial or complete absence of the cranial vault accompanied by absence of overlying tissues, including the brain and cerebral hemispheres, skull and scalp.",false,,,http://purl.obolibrary.org/obo/DOID_2490,,,,,,,,"A congenital nervous system abnormality characterized by failure of the anterior neuropore to close resulting in partial or complete absence of the cranial vault accompanied by absence of overlying tissues, including the brain and cerebral hemispheres, skull and scalp.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060668,,,,OMIM:206500|ICD10CM:00.0|ORDO:1048,,,,,DOID:0060668,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,anencephaly,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300188,"[""MAPKAPK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300188,,,,,,,,,,,,,,,,,,,,,,,,,,,,MAPKAPK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2649,"[""chondroblastoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_201,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2649,,,,SNOMEDCT_US_2016_03_01:189887007|SNOMEDCT_US_2016_03_01:9001003|MESH:D002804|SNOMEDCT_US_2016_03_01:134337007|NCI:C2945|UMLS_CUI:C0008441,Chondroblastoma of bone,,disease_ontology,,DOID:2649,,,,,,,,,,,,,,,,,,,chondroblastoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060422,"[""chromosome 6pter-p24 deletion syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060388,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060422,elvira,2015-09-28T17:55:16Z,,OMIM:612582|ORDO:96125|ICD10CM:Q93.5,distal monosomy 6p|6p25 microdeletion syndrome|6p subtelomeric deletion syndrome,,disease_ontology,,DOID:0060422,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,chromosome 6pter-p24 deletion syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060427,"[""chromosome Xp21 deletion syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060388,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060427,elvira,2015-09-29T16:13:28Z,,ICD10CM:Q99.8|OMIM:300679|ORDO:261476,monosomy Xp21|Xp21 microdeletion syndrome|complex glycerol kinase deficiency,,disease_ontology,,DOID:0060427,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,chromosome Xp21 deletion syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060420,"[""chromosome 4q21 deletion syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060388,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060420,elvira,2015-09-28T17:49:18Z,,OMIM:613509|ORDO:238750,4q21 microdeletion syndrome|monosomy 4q21,,disease_ontology,,DOID:0060420,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,chromosome 4q21 deletion syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000048,"[""LEU130 in PLK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000048,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU130 in PLK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100046,"[""C5a anaphylatoxin chemotactic receptor 1""]",,"A C5a anaphylatoxin chemotactic receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21730] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300027,,,,,,,,"A C5a anaphylatoxin chemotactic receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21730] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100046,,,,https://pharos.nih.gov/idg/targets/P21730,,,,,,,,,,,,,C5AR1,C5AR|C5R1,,P21730,,,,,,,,C5a anaphylatoxin chemotactic receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000369,"[""PLK3 kinase domain""]",,Serine/threonine-protein kinase PLK3; polo-like kinase 3 (Drosophila); CNK; FNK; PLK3; PRK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase PLK3; polo-like kinase 3 (Drosophila); CNK; FNK; PLK3; PRK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000369,,,,,,,,,,,,,,,,,,,200352,,,,,,,,,PLK3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400353,"[""Inward rectifier-type potassium channel family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400353,,,,,,,,,,,,,,,,,,,,,,,,,,,,Inward rectifier-type potassium channel family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100359,"[""Serine/threonine-protein kinase nek5""]",,"serine/threonine-protein kinase nek5 (NEK5)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase Nek5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6P3R8] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300197,,,,,,,,"serine/threonine-protein kinase nek5 (NEK5)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase Nek5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6P3R8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100359,,,,https://pharos.nih.gov/idg/targets/Q6P3R8,,,,,,,,,,,,,NEK5,,,Q6P3R8,,,,,,,,Serine/threonine-protein kinase nek5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004850,"[""bone marrow cell""]",,"The soft, fatty, vascular tissue that fills most bone cavities and is the source of red blood cells and many white blood cells.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The soft, fatty, vascular tissue that fills most bone cavities and is the source of red blood cells and many white blood cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004850,mgr,2010-10-08T12:44:00Z,,,,,BrendaTissueOBO,,BTO:0004850,,,,,,,,,,,,,,,,,,,bone marrow cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000036,"[""LEU116 in PIM2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000036,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU116 in PIM2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3783,"[""Coffin-Lowry syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050735,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3783,,,,NCI:C84643|MESH:D038921|UMLS_CUI:C0265252|SNOMEDCT_US_2016_03_01:15182000|OMIM:303600,Coffin-Lowry syndrome (disorder),,disease_ontology,,DOID:3783,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Coffin-Lowry syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000399,"[""eosinophil""]",,A white blood cell or other granulocyte with cytoplasmic inclusions readily stained by eosin.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000539,,,,,,,,A white blood cell or other granulocyte with cytoplasmic inclusions readily stained by eosin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000399,,,,,,,BrendaTissueOBO,eosinophilic leukocyte|eosinophil granulocyte|eosinocyte|eosinophilic leucocyte,BTO:0000399,,,,,,,,,,,,,,,,,,,eosinophil,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300227,"[""YANK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300227,,,,,,,,,,,,,,,,,,,,,,,,,,,,YANK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000160,"[""bundle sheath""]",,Sheath of parenchyma or sclerenchyma cells surrounding the vascular bundles in leaves.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Sheath of parenchyma or sclerenchyma cells surrounding the vascular bundles in leaves.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000160,,,,,,,BrendaTissueOBO,,BTO:0000160,,,,,,,,,,,,,,,,,,,bundle sheath,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200506,"[""OR1S1 gene""]",,"An olfactory receptor 1S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH92] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH92] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200506,,,,,,,,,,,,,,,,219959,OR1S1,,,,,,,,,,,OR1S1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100565,"[""Wee1-like protein kinase""]",,Wee1-like protein kinase (WEE1)  with  no mutation  in a nonphosphorylated state|A wee1-like protein kinase that is encoded in the genome of human. ,false,,,http://www.drugtargetontology.org/dto/DTO_03300212,,,,,,,,Wee1-like protein kinase (WEE1)  with  no mutation  in a nonphosphorylated state|A wee1-like protein kinase that is encoded in the genome of human. ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100565,,,,https://pharos.nih.gov/idg/targets/P30291,,,,,,,,,,,,,WEE1,,,P30291,,,,,,,,Wee1-like protein kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002343,"[""tarsal bone""]",,"Any of the seven bones of the tarsus. The seven bones constituting the articulation between the foot and the leg-the talus, calcaneus, and navicular, in the proximal row; and the cuboid and the lateral, intermediate, and medial cuneiform bones, in the distal row.",false,,,http://purl.obolibrary.org/obo/UBERON_0001474|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000140,,,,,,,,"Any of the seven bones of the tarsus. The seven bones constituting the articulation between the foot and the leg-the talus, calcaneus, and navicular, in the proximal row; and the cuboid and the lateral, intermediate, and medial cuneiform bones, in the distal row.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002343,,,,,,,BrendaTissueOBO,bony tarsus|tarsal|ossa tarsalia|tarsus osseus|ossa tarsi,BTO:0002343,,,,,,,,,,,,,,,,,,,tarsal bone,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000379,"[""RET(V804M) kinase domain""]",,Proto-oncogene tyrosine-protein kinase receptor Ret; CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET; RET51; RET-ELE1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Proto-oncogene tyrosine-protein kinase receptor Ret; CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET; RET51; RET-ELE1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000379,,,,,,,,,,,,,,,,,,,200373,,,,,,,,,RET(V804M) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100127,"[""Glycine receptor subunit alpha-2""]",,"A glycine receptor subunit alpha-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23416] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300526,,,,,,,,"A glycine receptor subunit alpha-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23416] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100127,,,,https://pharos.nih.gov/idg/targets/P23416,,,,,,,,,,,,,GLRA2,,,P23416,,,,,,,,Glycine receptor subunit alpha-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200130,"[""GPR111 gene""]",,"A G-protein coupled receptor 111 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,"A G-protein coupled receptor 111 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200130,,,,,,,,,,,,,,,,222611,GPR111,PGR20,,,,,,,,,,GPR111 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200555,"[""ULK1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400228,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200555,,,,,,,,,,,,,,,,8408,ULK1,KIAA0722,,,,,,,,,,ULK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12205,"[""dengue disease""]",,"A viral infectious disease that results_in infection, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom severe headache, has_symptom severe pain behind the eyes, has_symptom joint pain, has_symptom muscle and bone pain, has_symptom rash, and has_symptom mild bleeding.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in infection, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom severe headache, has_symptom severe pain behind the eyes, has_symptom joint pain, has_symptom muscle and bone pain, has_symptom rash, and has_symptom mild bleeding.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12205,,,DOID:0050142,SNOMEDCT_US_2016_03_01:38362002|UMLS_CUI:C0011311|MESH:D003715|NCI:C34528|ICD9CM:061|SNOMEDCT_US_2016_03_01:266194002|ICD10CM:A90|SNOMEDCT_US_2016_03_01:154345006,Dengue Fever|classic dengue|breakbone fever,,disease_ontology,classical dengue,DOID:12205,http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,dengue disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200235,"[""KCNQ4 gene""]",,"The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400564,,,,,,,,"The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200235,,,,,,,,,,,,,,,,9132,KCNQ4,,,,,,,,,,,KCNQ4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000240,"[""LRRK2(G2019S) kinase domain""]",,Leucine-rich repeat serine/threonine-protein kinase 2; AURA17; DARDARIN; LRRK2; PARK8; RIPK7; ROCO2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Leucine-rich repeat serine/threonine-protein kinase 2; AURA17; DARDARIN; LRRK2; PARK8; RIPK7; ROCO2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000240,,,,,,,,,,,,,,,,,,,200230,,,,,,,,,LRRK2(G2019S) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003045,"[""neuroma cell""]",,A tumor growing from a nerve or made up largely of nerve cells and nerve fibers.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A tumor growing from a nerve or made up largely of nerve cells and nerve fibers.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003045,,,,,,,BrendaTissueOBO,nerve cancer cell|nerve tumor cell,BTO:0003045,,,,,,,,,,,,,,,,,,,neuroma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000105,"[""DAPK1 kinase domain""]",,Death-associated protein kinase 1; DAPK; DAPK1; DKFZp781I035,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Death-associated protein kinase 1; DAPK; DAPK1; DKFZp781I035,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000105,,,,,,,,,,,,,,,,,,,200106,,,,,,,,,DAPK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100204,"[""Potassium voltage-gated channel subfamily G member 4""]",,"A voltage-gated potassium channel KCNG4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8TDN1] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300552,,,,,,,,"A voltage-gated potassium channel KCNG4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8TDN1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100204,,,,https://pharos.nih.gov/idg/targets/Q8TDN1,,,,,,,,,,,,,KCNG4,KCNG3,,Q8TDN1,,,,,,,,Potassium voltage-gated channel subfamily G member 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200243,"[""KCNV1 gene""]",,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This protein is essentially present in the brain, and its role might be to inhibit the function of a particular class of outward rectifier potassium channel types. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400572,,,,,,,,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This protein is essentially present in the brain, and its role might be to inhibit the function of a particular class of outward rectifier potassium channel types. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200243,,,,,,,,,,,,,,,,27012,KCNV1,,,,,,,,,,,KCNV1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300407,"[""CNGB3 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300343,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300407,,,,,,,,,,,,,,,,,,,,,,,,,,,,CNGB3 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9952,"[""acute lymphocytic leukemia""]",,A lymphoblastic leukemia that is characterized by over production of lymphoblasts.,false,,,http://purl.obolibrary.org/obo/DOID_1037,,,,,,,,A lymphoblastic leukemia that is characterized by over production of lymphoblasts.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9952,,,,SNOMEDCT_US_2016_03_01:90151006|ICD10CM:C91.0|ICD9CM:204.0|SNOMEDCT_US_2016_03_01:128822004|OMIM:615545|SNOMEDCT_US_2016_03_01:190034000|ORDO:513|OMIM:613065|SNOMEDCT_US_2016_03_01:91857003|NCI:C3167|OMIM:247640|OMIM:613067|EFO:0000220|ICD10CM:C91.00|SNOMEDCT_US_2016_03_01:154588002|UMLS_CUI:C0023449,acute lymphoblastic leukemia,,disease_ontology,,DOID:9952,http://purl.obolibrary.org/obo/doid#DO_cancer_slim|http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,acute lymphocytic leukemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003660,"[""laryngeal cartilage""]",,"The nine cartilages of the larynx, including the cricoid, thyroid and epiglottic, and two each of arytenoid, corniculate and cuneiform.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The nine cartilages of the larynx, including the cricoid, thyroid and epiglottic, and two each of arytenoid, corniculate and cuneiform.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003660,,,,,,,BrendaTissueOBO,,BTO:0003660,,,,,,,,,,,,,,,,,,,laryngeal cartilage,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_50,"[""thyroid gland disease""]",,An endocrine system disease that is located_in the thyroid.,false,,,http://purl.obolibrary.org/obo/DOID_28,,,,,,,,An endocrine system disease that is located_in the thyroid.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:50,,,,UMLS_CUI:C0040128|ICD9CM:240-246.99|SNOMEDCT_US_2016_03_01:190232008|SNOMEDCT_US_2016_03_01:14304000|MESH:D013959|ICD9CM:246.9|ICD10CM:E07.9|SNOMEDCT_US_2016_03_01:191036006|SNOMEDCT_US_2016_03_01:190311002|NCI:C26893|SNOMEDCT_US_2016_03_01:154649009|ICD10CM:E00-E07,,,disease_ontology,,DOID:50,,,,,,,,,,,,,,,,,,,thyroid gland disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_507,"[""adjustment disorder""]",,"A disease of mental health that is an abnormal and excessive emotional and behavioral reaction to a life stress that develops within 3 months of a life stress, and which is stronger or greater than what would be expected for the type of event that occurred.",false,,,http://purl.obolibrary.org/obo/DOID_150,,,,,,,,"A disease of mental health that is an abnormal and excessive emotional and behavioral reaction to a life stress that develops within 3 months of a life stress, and which is stronger or greater than what would be expected for the type of event that occurred.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:507,,,,SNOMEDCT_US_2016_03_01:367487002|SNOMEDCT_US_2016_03_01:63608001|ICD9CM:309|SNOMEDCT_US_2016_03_01:17226007|UMLS_CUI:C0040701|ICD9CM:309.9|SNOMEDCT_US_2016_03_01:268781004|SNOMEDCT_US_2016_03_01:192068001,adjustment reaction|adjustment disease,,disease_ontology,,DOID:507,,,,,,,,,,,,,,,,,,,adjustment disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100158,"[""Probable g-protein coupled receptor 157""]",,"A G-protein coupled receptor 157 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q5UAW9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300003,,,,,,,,"A G-protein coupled receptor 157 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q5UAW9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100158,,,,https://pharos.nih.gov/idg/targets/Q5UAW9,,,,,,,,,,,,,GPR157,,,Q5UAW9,,,,,,,,Probable g-protein coupled receptor 157,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004860,"[""GaMG cell""]",,Human glioblastoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001530,,,,,,,,Human glioblastoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004860,mgr,2010-10-11T02:49:33Z,,,,,BrendaTissueOBO,,BTO:0004860,,,,,,,,,,,,,,,,,,,GaMG cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200470,"[""OPRM1 gene""]",,"A mu-type opioid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35372] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A mu-type opioid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35372] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200470,,,,,,,,,,,,,,,,4988,OPRM1,MOR1,,,,,,,,,,OPRM1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200208,"[""KCNH4 gene""]",,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. The gene is brain-specific, and located in the neocortex and the striatum. It may be involved in cellular excitability of restricted neurons in the central nervous system. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400556,,,,,,,,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. The gene is brain-specific, and located in the neocortex and the striatum. It may be involved in cellular excitability of restricted neurons in the central nervous system. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200208,,,,,,,,,,,,,,,,23415,KCNH4,,,,,,,,,,,KCNH4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300182,"[""LISK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300107,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300182,,,,,,,,,,,,,,,,,,,,,,,,,,,,LISK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200797,"[""TAS2R7 gene""]",,"A taste receptor type 2 member 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400014,,,,,,,,"A taste receptor type 2 member 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200797,,,,,,,,,,,,,,,,50837,TAS2R7,,,,,,,,,,,TAS2R7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000192,"[""IKKB kinase domain""]",,Inhibitor of nuclear factor kappa-B kinase subunit beta,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Inhibitor of nuclear factor kappa-B kinase subunit beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000192,,,,,,,,,,,,,,,,,,,200195,,,,,,,,,IKKB kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100560,"[""Vascular endothelial growth factor receptor 2""]",,"A vascular endothelial growth factor receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35968] |vascular endothelial growth factor receptor 2 (VGFR2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300242,,,,,,,,"A vascular endothelial growth factor receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35968] |vascular endothelial growth factor receptor 2 (VGFR2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100560,,,,https://pharos.nih.gov/idg/targets/P35968,,,,,,,,,,,,,KDR,FLK1|VEGFR2,,P35968,,,,,,,,Vascular endothelial growth factor receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8200,"[""tertiary syphilis""]",,"A syphilis that is characterized as the third stage of syphilis that develops after the disappearance of the secondary symptoms and is marked by ulcers and gummas under the skin and commonly by involvement of the skeletal, cardiovascular, and nervous systems.",false,,,http://purl.obolibrary.org/obo/DOID_4166,,,,,,,,"A syphilis that is characterized as the third stage of syphilis that develops after the disappearance of the secondary symptoms and is marked by ulcers and gummas under the skin and commonly by involvement of the skeletal, cardiovascular, and nervous systems.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8200,,,,SNOMEDCT_US_2016_03_01:186905004|ICD9CM:097.0|ICD10CM:A52.9|MESH:C536774|SNOMEDCT_US_2016_03_01:72083004|SNOMEDCT_US_2016_03_01:187358009|SNOMEDCT_US_2016_03_01:276200006|ICD10CM:A52.3|UMLS_CUI:C0153188|ICD10CM:A52,late syphilis,,disease_ontology,,DOID:8200,http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease|http://purl.obolibrary.org/obo/doid#sexually_transmitted_infectious_disease,,,,,,,,,,,,,,,,,,tertiary syphilis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300259,"[""CCRK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300136,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300259,,,,,,,,,,,,,,,,,,,,,,,,,,,,CCRK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400127,"[""GRK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400127,,,,,,,,,,,,,,,,,,,,,,,,,,,,GRK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491036,"[""RIO3 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400217,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491036,,,,,,,,,,,,,,,,,,,,,,,,,,,,RIO3 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100664,"[""Olfactory receptor 6M1""]",,"An olfactory receptor 6M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGM8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGM8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100664,,,,https://pharos.nih.gov/idg/targets/Q8NGM8,,,,,,,,,,,,,OR6M1,,,Q8NGM8,,,,,,,,Olfactory receptor 6M1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100327,"[""Mitogen-activated protein kinase 15""]",,"mitogen-activated protein kinase 15 (ERK8)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase 15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TD08] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300295,,,,,,,,"mitogen-activated protein kinase 15 (ERK8)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase 15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TD08] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100327,,,,https://pharos.nih.gov/idg/targets/Q8TD08,,,,,,,,,,,,,MAPK15,ERK7|ERK8,,Q8TD08,,,,,,,,Mitogen-activated protein kinase 15,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000295,"[""MST1 kinase domain""]",,Serine/threonine kinase 4; DKFZp686A2068; KRS2; MST1; STK4; YSK3,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine kinase 4; DKFZp686A2068; KRS2; MST1; STK4; YSK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000295,,,,,,,,,,,,,,,,,,,200272,,,,,,,,,MST1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4500,"[""hypokalemia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0050032,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4500,,,,MESH:D007008|NCI:C34939|UMLS_CUI:C1514284,,,disease_ontology,hypopotassemia |potassium deficiency disorder ,DOID:4500,,,,,,,,,,,,,,,,,,,hypokalemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300378,"[""Acid-sensing ion channel 3 (ASIC3) subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300330,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300378,,,,,,,,,,,,,,,,,,,,,,,,,,,,Acid-sensing ion channel 3 (ASIC3) subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200107,"[""FZD5 gene""]",,"A frizzled-5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13467] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400043,,,,,,,,"A frizzled-5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13467] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200107,,,,,,,,,,,,,,,,7855,FZD5,C2orf31,,,,,,,,,,FZD5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000262,"[""MARK2 kinase domain""]",,Serine/threonine-protein kinase MARK2; MAP/microtubule affinity-regulating kinase 2; EMK1; EMK-1; MGC99619; PAR-1; Par1b,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase MARK2; MAP/microtubule affinity-regulating kinase 2; EMK1; EMK-1; MGC99619; PAR-1; Par1b,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000262,,,,,,,,,,,,,,,,,,,200247,,,,,,,,,MARK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200696,"[""OR8G5 gene""]",,"An olfactory receptor 8G5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG78] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 8G5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG78] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200696,,,,,,,,,,,,,,,,219865,OR8G5,OR8G5P|OR8G6,,,,,,,,,,OR8G5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400424,"[""KCNJ13 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400424,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ13 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1742,"[""drug psychosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1203,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1742,,,,SNOMEDCT_US_2016_03_01:191498001|UMLS_CUI:C0033937|SNOMEDCT_US_2016_03_01:191483003|SNOMEDCT_US_2016_03_01:154855001|ICD9CM:292.1|MESH:D011605,Drug-induced psychotic disorder|Drug-induced psychosis,,disease_ontology,,DOID:1742,,,,,,,,,,,,,,,,,,,drug psychosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200615,"[""OR5B12 gene""]",,"An olfactory receptor 5B12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R08] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5B12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R08] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200615,,,,,,,,,,,,,,,,390191,OR5B12,OR5B12P|OR5B16,,,,,,,,,,OR5B12 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005248,"[""M-07E cell""]",,A subline of the M-07 human megakaryoblastic leukemia cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A subline of the M-07 human megakaryoblastic leukemia cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005248,XPMUser,2011-10-01T10:14:39Z,,,,,BrendaTissueOBO,M07E cell|M-O7E cell|MO7E cell,BTO:0005248,,,,,,,,,,,,,,,,,,,M-07E cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200205,"[""KCNH1 gene""]",,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400553,,,,,,,,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200205,,,,,,,,,,,,,,,,3756,KCNH1,EAG|EAG1,,,,,,,,,,KCNH1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100805,"[""Trace amine-associated receptor 6""]",,"A trace amine-associated receptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96RI8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A trace amine-associated receptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96RI8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100805,,,,https://pharos.nih.gov/idg/targets/Q96RI8,,,,,,,,,,,,,TAAR6,TA4|TAR4|TRAR4,,Q96RI8,,,,,,,,Trace amine-associated receptor 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000015,"[""CCL1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000015,,,,,,,,,,,,,,,,,,,,,,,,,,,,CCL1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000121,"[""bile""]",,"A fluid secreted by the liver and poured into the small intestine via the bile ducts. Important constituents are conjugated bile salts, cholesterol, phospholipid, bilirubin diglucuronide, and electrolytes. Bile is alkaline due to its bicarbonate content, is golden brown to greenish yellow in color, and has a bitter taste. Bile secreted by the liver is concentrated in the gallbladder.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000346,,,,,,,,"A fluid secreted by the liver and poured into the small intestine via the bile ducts. Important constituents are conjugated bile salts, cholesterol, phospholipid, bilirubin diglucuronide, and electrolytes. Bile is alkaline due to its bicarbonate content, is golden brown to greenish yellow in color, and has a bitter taste. Bile secreted by the liver is concentrated in the gallbladder.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000121,,,,,,,BrendaTissueOBO,gall|fel,BTO:0000121,,,,,,,,,,,,,,,,,,,bile,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11678,"[""onchocerciasis""]",,"A filariasis that involves parasitic infection caused by the nematode Onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus Simulium. The worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. The symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy.",false,,,http://purl.obolibrary.org/obo/DOID_37|http://purl.obolibrary.org/obo/DOID_1080,,,,,,,,"A filariasis that involves parasitic infection caused by the nematode Onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus Simulium. The worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. The symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11678,,,,ICD9CM:125.3|NCI:C34861|MESH:D009855|ICD10CM:B73|SNOMEDCT_US_2016_03_01:38539003|UMLS_CUI:C0029001,volvulosis|Onchocerca volvulus infection|Infection by Onchocerca volvulus (disorder),,disease_ontology,,DOID:11678,,,,,,,,,,,,,,,,,,,onchocerciasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100611,"[""Olfactory receptor 5A1""]",,"An olfactory receptor 5A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100611,,,,https://pharos.nih.gov/idg/targets/Q8NGJ0,,,,,,,,,,,,,OR5A1,OR5A1P,,Q8NGJ0,,,,,,,,Olfactory receptor 5A1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5672,"[""large intestine cancer""]",,"An intestinal cancer that effects the long, tube-like organ that is connected to the small intestine at one end and the anus at the other.",false,,,http://purl.obolibrary.org/obo/DOID_10155,,,,,,,,"An intestinal cancer that effects the long, tube-like organ that is connected to the small intestine at one end and the anus at the other.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5672,,,DOID:1994|DOID:1997,SNOMEDCT_US_2016_03_01:363510005|UMLS_CUI:C0009402|SNOMEDCT_US_2016_03_01:408645001|SNOMEDCT_US_2016_03_01:93854002|ICD10CM:C18.9|UMLS_CUI:C0346629|NCI:C4978|UMLS_CUI:C1319315|NCI:C5105|NCI:C2955|MESH:D015179,,,disease_ontology,,DOID:5672,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,large intestine cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000068,"[""H1 relaxin""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000068,,,,,,,,,,,,,,,,,,,,,,,,,,,,H1 relaxin,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300436,"[""A (Shaker) subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300436,,,,,,,,,,,,,,,,,,,,,,,,,,,,A (Shaker) subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004339,"[""ScGT1 cell""]",,"Derived from the mouse hypothalamic cell line GT1, infected with mouse scrapie prions.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Derived from the mouse hypothalamic cell line GT1, infected with mouse scrapie prions.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004339,,,,,,,BrendaTissueOBO,,BTO:0004339,,,,,,,,,,,,,,,,,,,ScGT1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003449,"[""AML-12 cell""]",,Murine non-transformed normal liver cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000224,,,,,,,,Murine non-transformed normal liver cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003449,,,,,,,BrendaTissueOBO,AML 12 cell|AML12 cell,BTO:0003449,,,,,,,,,,,,,,,,,,,AML-12 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100274,"[""Leukocyte tyrosine kinase receptor""]",,"A leukocyte tyrosine kinase receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P29376] |leukocyte tyrosine kinase receptor (LTK)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300122,,,,,,,,"A leukocyte tyrosine kinase receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P29376] |leukocyte tyrosine kinase receptor (LTK)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100274,,,,https://pharos.nih.gov/idg/targets/P29376,,,,,,,,,,,,,LTK,TYK1,,P29376,,,,,,,,Leukocyte tyrosine kinase receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000297,"[""PHE93 in CDK4-cyclinD3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000297,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE93 in CDK4-cyclinD3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6988,"[""peripheral epithelioid sarcoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_6193,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6988,,,,NCI:C27473|UMLS_CUI:C1333306,,,disease_ontology,,DOID:6988,,,,,,,,,,,,,,,,,,,peripheral epithelioid sarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200148,"[""FES gene""]",,"This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400157,,,,,,,,"This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200148,,,,,,,,,,,,,,,,2242,FES,FPS,,,,,,,,,,FES gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200269,"[""GPR50 gene""]",,"A melatonin-related receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13585] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A melatonin-related receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13585] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200269,,,,,,,,,,,,,,,,9248,GPR50,,,,,,,,,,,GPR50 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000387,"[""THR701 in DDR1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000387,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR701 in DDR1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200226,"[""GUK1 gene""]",,"The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03491030,,,,,,,,"The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200226,,,,,,,,,,,,,,,,2987,GUK1,GMK,,,,,,,,,,GUK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001833,"[""parasympathetic nervous system""]",,"One of the two divisions of the vertebrate autonomic nervous sytem. Parasympathetic nerves emerge cranially as pre-ganglionic fibres from oculomotor, facial, glossopharyngeal and vagus, and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic acetylcholine receptors. The parasympathetic system innervates, for example, salivary glands, thoracic and abdominal viscera, bladder and genitalia.",false,,,http://purl.obolibrary.org/obo/BTO_0001028|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"One of the two divisions of the vertebrate autonomic nervous sytem. Parasympathetic nerves emerge cranially as pre-ganglionic fibres from oculomotor, facial, glossopharyngeal and vagus, and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic acetylcholine receptors. The parasympathetic system innervates, for example, salivary glands, thoracic and abdominal viscera, bladder and genitalia.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001833,,,,,,,BrendaTissueOBO,parasympathetic part of autonomic division of nervous system,BTO:0001833,,,,,,,,,,,,,,,,,,,parasympathetic nervous system,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300296,"[""MNK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300188,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300296,,,,,,,,,,,,,,,,,,,,,,,,,,,,MNK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100246,"[""Protein kinase c theta type""]",,"protein kinase c theta type (KPCT)  with  no mutation  in a nonphosphorylated state|A protein kinase C theta type that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q04759] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300277,,,,,,,,"protein kinase c theta type (KPCT)  with  no mutation  in a nonphosphorylated state|A protein kinase C theta type that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q04759] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100246,,,,https://pharos.nih.gov/idg/targets/Q04759,,,,,,,,,,,,,PRKCQ,PRKCT,,Q04759,,,,,,,,Protein kinase c theta type,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1936,"[""atherosclerosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2348,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1936,,,,MESH:D050197|EFO:0003914|SNOMEDCT_US_2016_03_01:194848007|ICD9CM:440|SNOMEDCT_US_2016_03_01:195251000|ICD10CM:I25.1|ICD10CM:I70|UMLS_CUI:C0004153|SNOMEDCT_US_2016_03_01:38716007|SNOMEDCT_US_2016_03_01:155382007|NCI:C35771|SNOMEDCT_US_2016_03_01:155414001|SNOMEDCT_US_2016_03_01:266318005|NCI:C35768,,,disease_ontology,,DOID:1936,,,,,,,,,,,,,,,,,,,atherosclerosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400392,"[""CFTR transporter subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400338,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400392,,,,,,,,,,,,,,,,,,,,,,,,,,,,CFTR transporter subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000384,"[""RIPK2 kinase domain""]",,Receptor-interacting serine/threonine-protein kinase 2; CARD3; CARDIAK; CCK; GIG30; RICK; RIP2; RIPK2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Receptor-interacting serine/threonine-protein kinase 2; CARD3; CARDIAK; CCK; GIG30; RICK; RIP2; RIPK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000384,,,,,,,,,,,,,,,,,,,200378,,,,,,,,,RIPK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100292,"[""Olfactory receptor 10a6""]",,"An olfactory receptor 10A6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH74] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10A6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH74] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100292,,,,https://pharos.nih.gov/idg/targets/Q8NH74,,,,,,,,,,,,,OR10A6,,,Q8NH74,,,,,,,,Olfactory receptor 10a6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2345,"[""plasma protein metabolism disease""]",,An inherited metabolic disorder that involves plasma protein metabolism malfunction.,false,,,http://purl.obolibrary.org/obo/DOID_655,,,,,,,,An inherited metabolic disorder that involves plasma protein metabolism malfunction.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2345,,,,SNOMEDCT_US_2016_03_01:190822009|SNOMEDCT_US_2016_03_01:190825006|UMLS_CUI:C0029594|ICD9CM:273.8,,,disease_ontology,,DOID:2345,,,,,,,,,,,,,,,,,,,plasma protein metabolism disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100019,"[""Acetylcholine receptor subunit delta""]",,"An acetylcholine receptor subunit delta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q07001] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300503,,,,,,,,"An acetylcholine receptor subunit delta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q07001] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100019,,,,https://pharos.nih.gov/idg/targets/Q07001,,,,,,,,,,,,,CHRND,ACHRD,,Q07001,,,,,,,,Acetylcholine receptor subunit delta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200121,"[""EIF2AK4 gene""]",,"This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400269,,,,,,,,"This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200121,,,,,,,,,,,,,,,,440275,EIF2AK4,GCN2|KIAA1338,,,,,,,,,,EIF2AK4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000272,"[""PHE691 in FLT3(ITD)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000272,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE691 in FLT3(ITD),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400512,"[""GABRB1 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400512,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRB1 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100591,"[""Olfactory receptor 4K2""]",,"An olfactory receptor 4K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100591,,,,https://pharos.nih.gov/idg/targets/Q8NGD2,,,,,,,,,,,,,OR4K2,,,Q8NGD2,,,,,,,,Olfactory receptor 4K2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000795,"[""L-5178-Y cell""]",,"Mouse T cell lymphoma, established from an 8-month-old female DBA/2 mouse with T cell lymphoma in 1985.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003212,,,,,,,,"Mouse T cell lymphoma, established from an 8-month-old female DBA/2 mouse with T cell lymphoma in 1985.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000795,,,,,,,BrendaTissueOBO,L5178Y cell,BTO:0000795,,,,,,,,,,,,,,,,,,,L-5178-Y cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1019,"[""osteomyelitis""]",,A bone inflammation disease that has_material_basis_in infection located_in bone or located_in bone marrow.,false,,,http://purl.obolibrary.org/obo/DOID_3342,,,,,,,,A bone inflammation disease that has_material_basis_in infection located_in bone or located_in bone marrow.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1019,,,DOID:10860|DOID:1018|DOID:14100|DOID:13673|DOID:1164|DOID:2250|DOID:11959|DOID:13674|DOID:12011|DOID:2249|DOID:5858|DOID:10281|DOID:11788|DOID:13678|DOID:10692|DOID:10282|DOID:1020|DOID:13737|DOID:13675|DOID:9456|DOID:13684|DOID:14166|DOID:14003,ICD9CM:730.10|SNOMEDCT_US_2016_03_01:203181001|SNOMEDCT_US_2016_03_01:203205002|UMLS_CUI:C0158372|UMLS_CUI:C0158381|UMLS_CUI:C0008707|ICD9CM:730.1|SNOMEDCT_US_2016_03_01:156800002|SNOMEDCT_US_2016_03_01:203183003|ICD9CM:730.11|ICD9CM:730.01|SNOMEDCT_US_2016_03_01:40970001|SNOMEDCT_US_2016_03_01:156791003,,,disease_ontology,,DOID:1019,,,,,,,,,,,,,,,,,,,osteomyelitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2797,"[""idiopathic interstitial pneumonia""]",,A pneumonia located_in the lung parenchyma of unknown cause.,false,,,http://purl.obolibrary.org/obo/DOID_552,,,,,,,,A pneumonia located_in the lung parenchyma of unknown cause.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2797,,,,SNOMEDCT_US_2016_03_01:196125002|SNOMEDCT_US_2016_03_01:196123009|ICD10CM:J84.114|SNOMEDCT_US_2016_03_01:233721005|ICD10CM:J84.11|SNOMEDCT_US_2016_03_01:196126001|MESH:D011658|SNOMEDCT_US_2016_03_01:155624004|SNOMEDCT_US_2016_03_01:45157009|SNOMEDCT_US_2016_03_01:236302005|UMLS_CUI:C0085786|SNOMEDCT_US_2016_03_01:129459004|SNOMEDCT_US_2016_03_01:266410004|SNOMEDCT_US_2016_03_01:700250006|ICD10CM:J84.112,Diffuse idiopathic pulmonary fibrosis|Idiopathic fibrosing alveolitis,,disease_ontology,IPF,DOID:2797,,,,,,,,,,,,,,,,,,,idiopathic interstitial pneumonia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200247,"[""LHCGR gene""]",,"A lutropin-choriogonadotropic hormone receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P22888] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400042,,,,,,,,"A lutropin-choriogonadotropic hormone receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P22888] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200247,,,,,,,,,,,,,,,,3973,LHCGR,LCGR|LGR2|LHRHR,,,,,,,,,,LHCGR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100265,"[""Melanocyte-stimulating hormone receptor""]",,"A melanocyte-stimulating hormone receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q01726] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300021,,,,,,,,"A melanocyte-stimulating hormone receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q01726] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100265,,,,https://pharos.nih.gov/idg/targets/Q01726,,,,,,,,,,,,,MC1R,MSHR,,Q01726,,,,,,,,Melanocyte-stimulating hormone receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200288,"[""OR10A2 gene""]",,"An olfactory receptor 10A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H208] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H208] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200288,,,,,,,,,,,,,,,,341276,OR10A2,OR10A2P,,,,,,,,,,OR10A2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200355,"[""OR14J1 gene""]",,"An olfactory receptor 14J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UGF5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 14J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UGF5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200355,,,,,,,,,,,,,,,,442191,OR14J1,OR5U1,,,,,,,,,,OR14J1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1826,"[""epilepsy""]",,"A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions.",false,,,http://purl.obolibrary.org/obo/DOID_936,,,,,,,,"A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1826,,,,ICD10CM:G40.909|SNOMEDCT_US_2016_03_01:84757009|SNOMEDCT_US_2016_03_01:246545002|UMLS_CUI:C0014544|SNOMEDCT_US_2016_03_01:155045005|SNOMEDCT_US_2016_03_01:155036009|MESH:D004827|SNOMEDCT_US_2016_03_01:267593008|SNOMEDCT_US_2016_03_01:271788002|SNOMEDCT_US_2016_03_01:128613002|ICD10CM:G40.9|EFO:0000474|SNOMEDCT_US_2016_03_01:313307000|SNOMEDCT_US_2016_03_01:267698007|NCI:C3020|SNOMEDCT_US_2016_03_01:193026007|ICD9CM:345.9,epileptic syndrome|epilepsy syndrome,,disease_ontology,,DOID:1826,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,epilepsy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400490,"[""Alpha-10/CHRNA10 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400490,,,,,,,,,,,,,,,,,,,,,,,,,,,,Alpha-10/CHRNA10 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100406,"[""Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform""]",,"phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHKG1)  with  no mutation  in a nonphosphorylated state|A phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16816] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300205,,,,,,,,"phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHKG1)  with  no mutation  in a nonphosphorylated state|A phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16816] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100406,,,,https://pharos.nih.gov/idg/targets/Q16816,,,,,,,,,,,,,PHKG1,PHKG,,Q16816,,,,,,,,"Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1426,"[""ureteral disease""]",,A urinary system disease that is located_in the ureter.,false,,,http://purl.obolibrary.org/obo/DOID_18,,,,,,,,A urinary system disease that is located_in the ureter.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1426,,,,MESH:D014515|UMLS_CUI:C0041954|NCI:C27148,,,disease_ontology,,DOID:1426,,,,,,,,,,,,,,,,,,,ureteral disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14264,"[""benign neonatal seizures""]",,A neonatal period electroclinical syndrome that is characterized by tonic-clonic seizures in newborns occurring within the first seven days of life and ceasing within the first 15 weeks of life and has_material_basis_in autosomal dominant inheritance of voltage-gated potassium channels or a chromosomal inversion.,false,,,http://purl.obolibrary.org/obo/DOID_0050702,,,,,,,,A neonatal period electroclinical syndrome that is characterized by tonic-clonic seizures in newborns occurring within the first seven days of life and ceasing within the first 15 weeks of life and has_material_basis_in autosomal dominant inheritance of voltage-gated potassium channels or a chromosomal inversion.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14264,,,,SNOMEDCT_US_2016_03_01:276724002|OMIM:121201|UMLS_CUI:C0270851|OMIM:269720|ORDO:1949|MESH:D020936|OMIM:121200|NCI:C84593|SNOMEDCT_US_2016_03_01:38281008,benign neonatal convulsions|benign familial neonatal seizures,,disease_ontology,,DOID:14264,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,benign neonatal seizures,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14261,"[""fragile X syndrome""]",,"An X-linked disease that is characterized by moderate to severe mental retardation, macroorchidism, and distinct facial features, including long face, large ears, and prominent jaw, and has_material_basis_in X-linked inheritance and a loss of FMR1 function.",false,,,http://purl.obolibrary.org/obo/DOID_0050735,,,,,,,,"An X-linked disease that is characterized by moderate to severe mental retardation, macroorchidism, and distinct facial features, including long face, large ears, and prominent jaw, and has_material_basis_in X-linked inheritance and a loss of FMR1 function.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14261,,,,ICD9CM:759.83|MESH:D005600|UMLS_CUI:C0016667|OMIM:300624|NCI:C84717|ICD10CM:Q99.2|SNOMEDCT_US_2016_03_01:613003|SNOMEDCT_US_2016_03_01:390007001,MARTIN-BELL SYNDROME|FRAGILE X MENTAL RETARDATION SYNDROME|MARKER X SYNDROME,,disease_ontology,,DOID:14261,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,fragile X syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14268,"[""sclerosing cholangitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_9446,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14268,,,,MESH:D015209|SNOMEDCT_US_2016_03_01:197443000|SNOMEDCT_US_2016_03_01:235917005|SNOMEDCT_US_2016_03_01:4032000|ICD10CM:K83.0|UMLS_CUI:C0008313|EFO:0004268,fibrosing cholangitis,,disease_ontology,,DOID:14268,,,,,,,,,,,,,,,,,,,sclerosing cholangitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100012,"[""Activin receptor type-1""]",,"activin receptor type-1 (ACVR1)  with  no mutation  in a nonphosphorylated state|An activin receptor type-1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q04771] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300246,,,,,,,,"activin receptor type-1 (ACVR1)  with  no mutation  in a nonphosphorylated state|An activin receptor type-1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q04771] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100012,,,,https://pharos.nih.gov/idg/targets/Q04771,,,,,,,,,,,,,ACVR1,ACVRLK2,,Q04771,,,,,,,,Activin receptor type-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9742,"[""pelvic varices""]",,,false,,,http://purl.obolibrary.org/obo/DOID_799,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9742,,,,SNOMEDCT_US_2016_03_01:266271008|SNOMEDCT_US_2016_03_01:195481006|ICD10CM:I86.2|UMLS_CUI:C0155795|SNOMEDCT_US_2016_03_01:17406005|ICD9CM:456.5,,,disease_ontology,,DOID:9742,,,,,,,,,,,,,,,,,,,pelvic varices,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1064,"[""cystinosis""]",,"A lysosomal storage disease characterized by the abnormal accumulation of cystine in the lysosomes. It follows an autosomal recessive inheritance pattern and has material basis in mutations in the CTNS gene, located on chromosome 17.",false,,,http://purl.obolibrary.org/obo/DOID_3211,,,,,,,,"A lysosomal storage disease characterized by the abnormal accumulation of cystine in the lysosomes. It follows an autosomal recessive inheritance pattern and has material basis in mutations in the CTNS gene, located on chromosome 17.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1064,,,,SNOMEDCT_US_2016_03_01:62332007|NCI:C2976|UMLS_CUI:C2931187|OMIM:219750|SNOMEDCT_US_2016_03_01:367374009|SNOMEDCT_US_2016_03_01:111398009|ORDO:213|ICD10CM:E72.04|OMIM:219800|SNOMEDCT_US_2016_03_01:190681003|SNOMEDCT_US_2016_03_01:190683000|OMIM:219900|MESH:D003554,cystine storage disease,,disease_ontology,,DOID:1064,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,cystinosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050026,"[""human monocytic ehrlichiosis""]",,"An ehrlichiosis that results_in infection located_in monocyte or located_in macrophage, has_material_basis_in Ehrlichia chaffeensis, which is transmitted_by black-legged tick (Ixodes scapularis), transmitted_by western black-legged tick (Ixodes pacificus) or transmitted_by castor bean tick (Ixodes ricinus,). The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue, has_symptom fever and has_symptom rash.",false,,,http://purl.obolibrary.org/obo/DOID_10242,,,,,,,,"An ehrlichiosis that results_in infection located_in monocyte or located_in macrophage, has_material_basis_in Ehrlichia chaffeensis, which is transmitted_by black-legged tick (Ixodes scapularis), transmitted_by western black-legged tick (Ixodes pacificus) or transmitted_by castor bean tick (Ixodes ricinus,). The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue, has_symptom fever and has_symptom rash.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050026,,,DOID:14091,,,,disease_ontology,Ehrlichiosis chafeensis,DOID:0050026,http://purl.obolibrary.org/obo/doid#tick-borne_infectious_disease|http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease,,,,,,,,,,,,,,,,,,human monocytic ehrlichiosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050025,"[""human granulocytic anaplasmosis""]",,"An ehrlichiosis that results_in infection located_in granular leukocyte, has_material_basis_in Anaplasma phagocytophilum, which is transmitted_by lone start tick (Amblyomma americanum ). The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue, has_symptom fever and has_symptom rash.",false,,,http://purl.obolibrary.org/obo/DOID_10242,,,,,,,,"An ehrlichiosis that results_in infection located_in granular leukocyte, has_material_basis_in Anaplasma phagocytophilum, which is transmitted_by lone start tick (Amblyomma americanum ). The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue, has_symptom fever and has_symptom rash.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050025,,,DOID:0050022|DOID:0050021,,human granulocytic ehrlichiosis,,disease_ontology,HGE,DOID:0050025,http://purl.obolibrary.org/obo/doid#tick-borne_infectious_disease|http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease,,,,,,,,,,,,,,,,,,human granulocytic anaplasmosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000088,"[""LEU98 in STK16""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000088,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU98 in STK16,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100016,"[""Adenosine receptor a3""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100016,,,,https://pharos.nih.gov/idg/targets/P0DMS8,,,,,,,,,,,,,ADORA3,,,P0DMS8,,,,,,,,Adenosine receptor a3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80339,"[""Adrenomedullin""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG COMPOUND:C16127|KEGG COMPOUND:148498-78-6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80339,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80339,,,,,Adrenomedullin,,CHEBI:80339,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000425,"[""TAK1 kinase domain""]",,Mitogen-activated protein kinase kinase kinase 7; MAP3K7; MEKK7; TAK1; TGF1a,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase kinase kinase 7; MAP3K7; MEKK7; TAK1; TGF1a,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000425,,,,,,,,,,,,,,,,,,,200426,,,,,,,,,TAK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200044,"[""BMPR1A gene""]",,"The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400246,,,,,,,,"The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200044,,,,,,,,,,,,,,,,657,BMPR1A,ACVRLK3|ALK3,,,,,,,,,,BMPR1A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200618,"[""PFKM gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200618,,,,,,,,,,,,,,,,,,,,,,,,,,,,PFKM gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117489,"[""Nuclear receptor subfamily 1 group d member 2""]",,"A nuclear receptor subfamily 1 group D member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14995] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117463,,,,,,,,"A nuclear receptor subfamily 1 group D member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14995] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117489,,,,https://pharos.nih.gov/idg/targets/Q14995,,,,,,,,,,,,,NR1D2,,,Q14995,,,,,,,,Nuclear receptor subfamily 1 group d member 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004765,"[""UKE-1 cell""]",,Acute myeloid leukemia cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0001883|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Acute myeloid leukemia cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004765,mgr,2010-10-02T10:22:54Z,,,,,BrendaTissueOBO,,BTO:0004765,,,,,,,,,,,,,,,,,,,UKE-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002660,"[""inflorescence stalk""]",,The inflorescence stalk is the main stem of the inflorescence that connects to the plant.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The inflorescence stalk is the main stem of the inflorescence that connects to the plant.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002660,,,,,,,BrendaTissueOBO,inflorescence stem,BTO:0002660,,,,,,,,,,,,,,,,,,,inflorescence stalk,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001869,"[""olfactory tubercle""]",,A small area of gray matter behind the olfactory trigone that is noted for receiving dopaminergic neurons from the substantia nigra and the reticular formation which have been implicated in schizoaffective disorders.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A small area of gray matter behind the olfactory trigone that is noted for receiving dopaminergic neurons from the substantia nigra and the reticular formation which have been implicated in schizoaffective disorders.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001869,,,,,,,BrendaTissueOBO,,BTO:0001869,,,,,,,,,,,,,,,,,,,olfactory tubercle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200607,"[""NAGK gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200607,,,,,,,,,,,,,,,,,,,,,,,,,,,,NAGK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002085,"[""chamber of the eye""]",,One of he various spaces in the eyeball.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,One of he various spaces in the eyeball.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002085,,,,,,,BrendaTissueOBO,chamber of eye,BTO:0002085,,,,,,,,,,,,,,,,,,,chamber of the eye,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000763,"[""lung""]",,One of the usually paired compound saccular thoracic organs that constitute the basic respiratory organ of air-breathing vertebrates.,false,,,http://purl.obolibrary.org/obo/BTO_0000203|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,,One of the usually paired compound saccular thoracic organs that constitute the basic respiratory organ of air-breathing vertebrates.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000763,,,,,,,BrendaTissueOBO,lung parenchyma|parenchyma of lung,BTO:0000763,,,,,,,,,,,,,,,,,,,lung,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000017,"[""ABL1(Q252H) kinase domain""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000017,,,,,,,,,,,,,,,,,,,,,,,,,,,,ABL1(Q252H) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005583,"[""promonocytic leukemia cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000737,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005583,Marion,2014-03-05T19:34:41Z,,,,,BrendaTissueOBO,,BTO:0005583,,,,,,,,,,,,,,,,,,,promonocytic leukemia cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1664,"[""pineoblastoma""]",,A pineal gland neoplasm located_in the brain.,false,,,http://purl.obolibrary.org/obo/DOID_5032,,,,,,,,A pineal gland neoplasm located_in the brain.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1664,,,,UMLS_CUI:C0205898|SNOMEDCT_US_2016_03_01:31671006|MESH:D010871|NCI:C9344,Pineal PNET,,disease_ontology,,DOID:1664,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,pineoblastoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100229,"[""Small conductance calcium-activated potassium channel protein 2""]",,"A small conductance calcium-activated potassium channel protein 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9H2S1] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300437,,,,,,,,"A small conductance calcium-activated potassium channel protein 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9H2S1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100229,,,,https://pharos.nih.gov/idg/targets/Q9H2S1,,,,,,,,,,,,,KCNN2,,,Q9H2S1,,,,,,,,Small conductance calcium-activated potassium channel protein 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117499,"[""Hepatocyte nuclear factor 4-alpha""]",,"A hepatocyte nuclear factor 4-alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41235] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117467,,,,,,,,"A hepatocyte nuclear factor 4-alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41235] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117499,,,,https://pharos.nih.gov/idg/targets/P41235,,,,,,,,,,,,,HNF4A,NR2A1,,P41235,,,,,,,,Hepatocyte nuclear factor 4-alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000010,"[""GLN118 in SgK110""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30011,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000010,,,,,,,,,,,,,,,,,,,,,,,,,,,,GLN118 in SgK110,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200564,"[""VRK3 gene""]",,"This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation activity. The protein, however, likely retains its substrate binding capability. This gene is widely expressed in human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400243,,,,,,,,"This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation activity. The protein, however, likely retains its substrate binding capability. This gene is widely expressed in human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200564,,,,,,,,,,,,,,,,51231,VRK3,,,,,,,,,,,VRK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100293,"[""Sodium channel protein type 3 subunit alpha""]",,"A sodium channel protein type 3 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NY46] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300467,,,,,,,,"A sodium channel protein type 3 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NY46] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100293,,,,https://pharos.nih.gov/idg/targets/Q9NY46,,,,,,,,,,,,,SCN3A,KIAA1356|NAC3,,Q9NY46,,,,,,,,Sodium channel protein type 3 subunit alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001009,"[""PC-12 cell""]",,"Rat adrenal pheochromocytoma established from a transplantable rat adrenal pheochromocytoma in 1976; cells were described to synthesize catecholamines (dopamine, norepinephrine); in response to nerve growth factor (NGF) a neuronal phenotype could be induced reversibly.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000201,,,,,,,,"Rat adrenal pheochromocytoma established from a transplantable rat adrenal pheochromocytoma in 1976; cells were described to synthesize catecholamines (dopamine, norepinephrine); in response to nerve growth factor (NGF) a neuronal phenotype could be induced reversibly.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001009,,,,,,,BrendaTissueOBO,PC12 cell|pheochromocytoma 12 cell,BTO:0001009,,,,,,,,,,,,,,,,,,,PC-12 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100547,"[""Olfactory receptor 2T3""]",,"An olfactory receptor 2T3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH03] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2T3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH03] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100547,,,,https://pharos.nih.gov/idg/targets/Q8NH03,,,,,,,,,,,,,OR2T3,,,Q8NH03,,,,,,,,Olfactory receptor 2T3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005098,"[""epidermal stem cell""]",,"The epidermal stem cells give rise to keratinocytes, which migrate to the surface of the skin and form a protective layer.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0005097,,,,,,,,"The epidermal stem cells give rise to keratinocytes, which migrate to the surface of the skin and form a protective layer.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005098,XPMUser,2011-03-21T08:26:55Z,,,,,BrendaTissueOBO,,BTO:0005098,,,,,,,,,,,,,,,,,,,epidermal stem cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200512,"[""TAB1 gene""]",,"The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,"The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200512,,,,,,,,,,,,,,,,10454,TAB1,MAP3K7IP1,,,,,,,,,,TAB1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400189,"[""AXL family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400189,,,,,,,,,,,,,,,,,,,,,,,,,,,,AXL family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004365,"[""gastroesophageal cancer cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004365,,,,,,,BrendaTissueOBO,gastro-esophageal cancer cell|gastroesophageal carcinoma cell|gastro-oesophageal cancer cell|gastroesophageal junction carcinoma cell,BTO:0004365,,,,,,,,,,,,,,,,,,,gastroesophageal cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000144,"[""Urotensin-related peptide""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000144,,,,,,,,,,,,,,,,,,,,,,,,,,,,Urotensin-related peptide,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100353,"[""Serine/threonine-protein kinase nek10""]",,"A serine/threonine-protein kinase Nek10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6ZWH5] |serine/threonine-protein kinase nek10 (NEK10)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300197,,,,,,,,"A serine/threonine-protein kinase Nek10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6ZWH5] |serine/threonine-protein kinase nek10 (NEK10)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100353,,,,https://pharos.nih.gov/idg/targets/Q6ZWH5,,,,,,,,,,,,,NEK10,,,Q6ZWH5,,,,,,,,Serine/threonine-protein kinase nek10,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000083,"[""CDKL1 kinase domain""]",,Cyclin-dependent kinase-like 1 (CDC2-related kinase); CDKL1; KKIALRE; P42,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Cyclin-dependent kinase-like 1 (CDC2-related kinase); CDKL1; KKIALRE; P42,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000083,,,,,,,,,,,,,,,,,,,200083,,,,,,,,,CDKL1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200405,"[""OR51S1 gene""]",,"An olfactory receptor 51S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 51S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200405,,,,,,,,,,,,,,,,119692,OR51S1,,,,,,,,,,,OR51S1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003651,"[""spindle cell""]",,"A fusiform cell, such as those in the deeper layers of the cerebral cortex.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002322,,,,,,,,"A fusiform cell, such as those in the deeper layers of the cerebral cortex.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003651,,,,,,,BrendaTissueOBO,,BTO:0003651,,,,,,,,,,,,,,,,,,,spindle cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391006,"[""AK3 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391014,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391006,,,,,,,,,,,,,,,,,,,,,,,,,,,,AK3 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000771,"[""macroglia""]",,"Neuroglial cells of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together. Originally, the term was used for the astrocytes alone.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000524|http://purl.obolibrary.org/obo/BTO_0002606,,,,,,,,"Neuroglial cells of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together. Originally, the term was used for the astrocytes alone.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000771,,,,,,,BrendaTissueOBO,macroglial cell,BTO:0000771,,,,,,,,,,,,,,,,,,,macroglia,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100468,"[""Protein o-mannose kinase""]",,"A protein kinase-like protein SgK196 that is encoded in the genome of human. [OMA:HUMAN26853, PRO:DNx] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300218,,,,,,,,"A protein kinase-like protein SgK196 that is encoded in the genome of human. [OMA:HUMAN26853, PRO:DNx] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100468,,,,https://pharos.nih.gov/idg/targets/Q9H5K3,,,,,,,,,,,,,POMK,SGK196,,Q9H5K3,,,,,,,,Protein o-mannose kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100356,"[""Serine/threonine-protein kinase nek2""]",,"A serine/threonine-protein kinase Nek2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51955] |serine/threonine-protein kinase nek2 (NEK2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300197,,,,,,,,"A serine/threonine-protein kinase Nek2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51955] |serine/threonine-protein kinase nek2 (NEK2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100356,,,,https://pharos.nih.gov/idg/targets/P51955,,,,,,,,,,,,,NEK2,NEK2A|NLK1,,P51955,,,,,,,,Serine/threonine-protein kinase nek2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100373,"[""Olfactory receptor 2T33""]",,"An olfactory receptor 2T33 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG76] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2T33 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG76] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100373,,,,https://pharos.nih.gov/idg/targets/Q8NG76,,,,,,,,,,,,,OR2T33,,,Q8NG76,,,,,,,,Olfactory receptor 2T33,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000109,"[""MET121 in PKAC-beta""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000109,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET121 in PKAC-beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002861,"[""esophageal squamous cell carcinoma cell""]",,"Squamous cell carcinoma is the most common type of esophageal cancer, accounting for 95% of all esophageal cancers worldwide.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001577,,,,,,,,"Squamous cell carcinoma is the most common type of esophageal cancer, accounting for 95% of all esophageal cancers worldwide.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002861,,,,,,,BrendaTissueOBO,ESCC cell,BTO:0002861,,,,,,,,,,,,,,,,,,,esophageal squamous cell carcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100172,"[""G-protein coupled receptor family C group 5 member B""]",,"A G-protein coupled receptor family C group 5 member B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZH0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300004,,,,,,,,"A G-protein coupled receptor family C group 5 member B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZH0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100172,,,,https://pharos.nih.gov/idg/targets/Q9NZH0,,,,,,,,,,,,,GPRC5B,RAIG2,,Q9NZH0,,,,,,,,G-protein coupled receptor family C group 5 member B,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000535,"[""germ cell""]",,1. A gamete (as an egg or sperm cell) or one of its antecedent cells. 2. A mature male or female germ cell usually possessing a haploid chromosome set and capable of initiating formation of a new diploid individual by fusion with a gamete of the opposite sex.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,1. A gamete (as an egg or sperm cell) or one of its antecedent cells. 2. A mature male or female germ cell usually possessing a haploid chromosome set and capable of initiating formation of a new diploid individual by fusion with a gamete of the opposite sex.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000535,,,,,,,BrendaTissueOBO,gamete,BTO:0000535,,,,,,,,,,,,,,,,,,,germ cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11394,"[""adult respiratory distress syndrome""]",,"A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.",false,,,http://purl.obolibrary.org/obo/DOID_11162,,,,,,,,"A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11394,,,,SNOMEDCT_US_2016_03_01:196154008|MESH:D012128|ICD10CM:J80|NCI:C3353|SNOMEDCT_US_2016_03_01:67782005|SNOMEDCT_US_2016_03_01:155627006|SNOMEDCT_US_2016_03_01:196150004|UMLS_CUI:C0035222|SNOMEDCT_US_2016_03_01:206281003|SNOMEDCT_US_2016_03_01:266411000,Non-cardiogenic pulmonary edema|Shock lung|adult RDS|ARDS,,disease_ontology,,DOID:11394,,,,,,,,,,,,,,,,,PRISM.,,adult respiratory distress syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11396,"[""pulmonary edema""]",,,false,,,http://purl.obolibrary.org/obo/DOID_11162,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11396,,,DOID:13472,MESH:D011654|ICD10CM:J81|NCI:C26868|SNOMEDCT_US_2016_03_01:196119001|UMLS_CUI:C0034063|ICD10CM:J81.1|SNOMEDCT_US_2016_03_01:266408001|SNOMEDCT_US_2016_03_01:19242006,,,disease_ontology,,DOID:11396,,,,,,,,,,,,,,,,,,,pulmonary edema,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200038,"[""APLNR gene""]",,"An apelin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35414] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400024,,,,,,,,"An apelin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35414] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200038,,,,,,,,,,,,,,,,187,APLNR,AGTRL1|APJ,,,,,,,,,,APLNR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200557,"[""OR2W5 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200557,,,,,,,,,,,,,,,,441932,OR2W5,OR2W5P,,,,,,,,,,OR2W5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5517,"[""stomach carcinoma""]",,A stomach cancer that is located_in the stomach.,false,,,http://purl.obolibrary.org/obo/DOID_305|http://purl.obolibrary.org/obo/DOID_10534,,,,,,,,A stomach cancer that is located_in the stomach.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5517,,,,SNOMEDCT_US_2016_03_01:154446008|UMLS_CUI:C0699791|SNOMEDCT_US_2016_03_01:372143007|NCI:C4911|EFO:0000178|SNOMEDCT_US_2016_03_01:255080008,carcinoma of stomach (disorder)|carcinoma of stomach|gastric carcinoma|cancer of the stomach,,disease_ontology,,DOID:5517,,,,,,,,,,,,,,,,,,,stomach carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050083,"[""Keshan disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5113,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050083,,,,,,,disease_ontology,,DOID:0050083,,,,,,,,,,,,,,,,,,,Keshan disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100073,"[""Corticotropin-releasing factor receptor 2""]",,"A corticotropin-releasing factor receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13324] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300036,,,,,,,,"A corticotropin-releasing factor receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13324] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100073,,,,https://pharos.nih.gov/idg/targets/Q13324,,,,,,,,,,,,,CRHR2,CRF2R|CRH2R,,Q13324,,,,,,,,Corticotropin-releasing factor receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000396,"[""THR790 in EGFR(G719C)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000396,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR790 in EGFR(G719C),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300482,"[""STrpC subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300360,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300482,,,,,,,,,,,,,,,,,,,,,,,,,,,,STrpC subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004617,"[""mucilage""]",,A gelatinous substance of various plants (as legumes or seaweeds) that contains protein and polysaccharides and is similar to plant gums .,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A gelatinous substance of various plants (as legumes or seaweeds) that contains protein and polysaccharides and is similar to plant gums .,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004617,XPMUser,2011-03-07T08:23:33Z,,,,,BrendaTissueOBO,,BTO:0004617,,,,,,,,,,,,,,,,,,,mucilage,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100605,"[""Olfactory receptor 4q2""]",,"An olfactory receptor 4Q2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C623] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4Q2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C623] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100605,,,,https://pharos.nih.gov/idg/targets/P0C623,,,,,,,,,,,,,OR4Q2,OR4Q2P,,P0C623,,,,,,,,Olfactory receptor 4q2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004255,"[""Ewing's family tumor cell""]",,"The Ewing's family of tumors includes Ewing's tumor of bone, extraosseus Ewing's sarcoma, primitive neuroectodermal tumors, and Askin's tumor. All of these tumors are derived from the same primordial stem cell, the primitive nerve cell.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000372,,,,,,,,"The Ewing's family of tumors includes Ewing's tumor of bone, extraosseus Ewing's sarcoma, primitive neuroectodermal tumors, and Askin's tumor. All of these tumors are derived from the same primordial stem cell, the primitive nerve cell.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004255,,,,,,,BrendaTissueOBO,EFT cell,BTO:0004255,,,,,,,,,,,,,,,,,,,Ewing's family tumor cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050890,"[""synucleinopathy""]",,"A neurodegenerative disease that is characterized by the abnormal accumulation of aggregates of alpha-synuclein protein in neurons, nerve fibres or glial cells.",false,,,http://purl.obolibrary.org/obo/DOID_1289,,,,,,,,"A neurodegenerative disease that is characterized by the abnormal accumulation of aggregates of alpha-synuclein protein in neurons, nerve fibres or glial cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050890,lschriml,2014-08-14T03:29:17Z,,,alpha Synucleinopathies ,,disease_ontology,Synucleinopathies ,DOID:0050890,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,synucleinopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050891,"[""adrenal cortical adenoma""]",,An adrenal adenoma that is a benign tumor of the adrenal cortex.,false,,,http://purl.obolibrary.org/obo/DOID_656,,,,,,,,An adrenal adenoma that is a benign tumor of the adrenal cortex.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050891,lschriml,2014-09-04T01:54:59Z,,,adrenocortical adenoma,,disease_ontology,,DOID:0050891,,,,,,,,,,,,,,,,,,,adrenal cortical adenoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050894,"[""ameloblastoma""]",,A cell type benign neoplasm that has_material_basis_in odontogenic epithelium.,false,,,http://purl.obolibrary.org/obo/DOID_0060084,,,,,,,,A cell type benign neoplasm that has_material_basis_in odontogenic epithelium.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050894,lschriml,2014-09-11T02:44:50Z,,,,,disease_ontology,,DOID:0050894,,,,,,,,,,,,,,,,,,,ameloblastoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200554,"[""UHMK1 gene""]",,"The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400241,,,,,,,,"The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200554,,,,,,,,,,,,,,,,127933,UHMK1,KIS|KIST,,,,,,,,,,UHMK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5200,"[""urinary tract obstruction""]",,,false,,,http://purl.obolibrary.org/obo/DOID_18,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5200,,,,SNOMEDCT_US_2016_03_01:197936002|NCI:C3675|SNOMEDCT_US_2016_03_01:266636004|UMLS_CUI:C0178879|ICD9CM:599.6|ICD9CM:599.60|SNOMEDCT_US_2016_03_01:7163005|ICD10CM:N13.9|SNOMEDCT_US_2016_03_01:266567006|NCI:C79805,Obstructive Uropathy|urinary obstruction,,disease_ontology,,DOID:5200,,,,,,,,,,,,,,,,,,,urinary tract obstruction,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400079,"[""Proteinase-activated receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400079,,,,,,,,,,,,,,,,,,,,,,,,,,,,Proteinase-activated receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100795,"[""Taste receptor type 2 member 4""]",,"A taste receptor type 2 member 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300014,,,,,,,,"A taste receptor type 2 member 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100795,,,,https://pharos.nih.gov/idg/targets/Q9NYW5,,,,,,,,,,,,,TAS2R4,,,Q9NYW5,,,,,,,,Taste receptor type 2 member 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300544,"[""Kv3.4/KCNC4 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300443,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300544,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv3.4/KCNC4 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001700,"[""cancellous bone""]",,"Bone substance made up of thin intersecting lamellae, usually found internal to compact bone.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Bone substance made up of thin intersecting lamellae, usually found internal to compact bone.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001700,,,,,,,BrendaTissueOBO,spongy bone|cancellated bone|substantia spongiosa ossium|trabecular bone|substantia trabecularis ossium|trabecular substance,BTO:0001700,,,,,,,,,,,,,,,,,,,cancellous bone,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1673,"[""pneumothorax""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1532,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1673,,,,SNOMEDCT_US_2016_03_01:196251008|ICD10CM:J93.1|UMLS_CUI:C0029850|SNOMEDCT_US_2016_03_01:266367007|SNOMEDCT_US_2016_03_01:196105001|SNOMEDCT_US_2016_03_01:196103008,,,disease_ontology,,DOID:1673,,,,,,,,,,,,,,,,,,,pneumothorax,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400241,"[""KIS family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400241,,,,,,,,,,,,,,,,,,,,,,,,,,,,KIS family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000108,"[""DCAMKL2 kinase domain""]",,Doublecortin-like kinase 2; CL2; CLICK2; CLICK-II; CLIK2; DCAMKL2; DCDC3; DCDC3B; DCK2; DCLK2; DKFZp761l032; MGC45428,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Doublecortin-like kinase 2; CL2; CLICK2; CLICK-II; CLIK2; DCAMKL2; DCDC3; DCDC3B; DCK2; DCLK2; DKFZp761l032; MGC45428,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000108,,,,,,,,,,,,,,,,,,,200110,,,,,,,,,DCAMKL2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000209,"[""MET85 in ULK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000209,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET85 in ULK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003216,"[""melan-a cell""]",,"Melan-a cells are an immortal pigmented mouse cell line, cultured from epidermal melanoblasts from embryos of inbred C57BL mice.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Melan-a cells are an immortal pigmented mouse cell line, cultured from epidermal melanoblasts from embryos of inbred C57BL mice.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003216,,,,,,,BrendaTissueOBO,,BTO:0003216,,,,,,,,,,,,,,,,,,,melan-a cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000833,"[""RBL-2H3 cell""]",,"Rat basophilic leukemia (RBL) cell line, obtained by Eccleston et al. and was maintained by serial passage in neonatal Wistar rats. Four cell lines (named RBL I-IV) were started from this tumor between 1973 and 1975. The subline RBL-IV HR+ was derived from RBL-IV, further subcloning established the cell line RBL-2H3. Cells are described to release histamine as an IgE-mediated reaction.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001018,,,,,,,,"Rat basophilic leukemia (RBL) cell line, obtained by Eccleston et al. and was maintained by serial passage in neonatal Wistar rats. Four cell lines (named RBL I-IV) were started from this tumor between 1973 and 1975. The subline RBL-IV HR+ was derived from RBL-IV, further subcloning established the cell line RBL-2H3. Cells are described to release histamine as an IgE-mediated reaction.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000833,,,,,,,BrendaTissueOBO,RBL2H3 cell,BTO:0000833,,,,,,,,,,,,,,,,,,,RBL-2H3 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200645,"[""OR5T1 gene""]",,"An olfactory receptor 5T1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG75] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5T1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG75] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200645,,,,,,,,,,,,,,,,390155,OR5T1,OR5T1P,,,,,,,,,,OR5T1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000120,"[""Neuromedin U-25""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000120,,,,,,,,,,,,,,,,,,,,,,,,,,,,Neuromedin U-25,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_403,"[""mouth disease""]",,A gastrointestinal system disease that is located_in the mouth.,false,,,http://purl.obolibrary.org/obo/DOID_77,,,,,,,,A gastrointestinal system disease that is located_in the mouth.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:403,,,,UMLS_CUI:C0026636|SNOMEDCT_US_2016_03_01:266484002|NCI:C27641|MESH:D009059|NCI:C3240|SNOMEDCT_US_2016_03_01:155630004|SNOMEDCT_US_2016_03_01:118938008,,,disease_ontology,,DOID:403,,,,,,,,,,,,,,,,,,,mouth disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_409,"[""liver disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3118,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:409,,,DOID:2165|DOID:2164|DOID:46,SNOMEDCT_US_2016_03_01:155807008|SNOMEDCT_US_2016_03_01:155817003|ICD10CM:K76.9|UMLS_CUI:C0023895|SNOMEDCT_US_2016_03_01:235856003|MESH:D008107|ICD10CM:K70-K77|SNOMEDCT_US_2016_03_01:266535008|SNOMEDCT_US_2016_03_01:62857009|SNOMEDCT_US_2016_03_01:155822003|NCI:C3196|SNOMEDCT_US_2016_03_01:197375001|SNOMEDCT_US_2016_03_01:197551000|ICD9CM:573.9,disorder of liver (disorder)|hepatic disorder,,disease_ontology,,DOID:409,,,,,,,,,,,,,,,,,,,liver disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_404,"[""gastrointestinal tuberculosis""]",,"An abdominal tuberculosis that results_in infection located_in gastrointestinal tract. The infection has_symptom abdominal pain, has_symptom weight loss, has_symptom fever, has_symptom anorexia, has_symptom change in bowel habits, has_symptom nausea, and has_symptom vomiting.",false,,,http://purl.obolibrary.org/obo/DOID_0050599,,,,,,,,"An abdominal tuberculosis that results_in infection located_in gastrointestinal tract. The infection has_symptom abdominal pain, has_symptom weight loss, has_symptom fever, has_symptom anorexia, has_symptom change in bowel habits, has_symptom nausea, and has_symptom vomiting.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:404,,,DOID:9802,SNOMEDCT_US_2016_03_01:154286002|MESH:D014385|UMLS_CUI:C0041312|SNOMEDCT_US_2016_03_01:240376003|SNOMEDCT_US_2016_03_01:186228005,"Tuberculosis of intestines, peritoneum and mesenteric glands (disorder)|Tuberculosis of gastrointestinal tract NOS (disorder)|Tuberculosis of intestines, peritoneum, and mesenteric glands|Tuberculosis of gastrointestinal tract|Tuberculosis of gastrointestinal tract (disorder)|tuberculosis of intestines, peritoneum and mesenteric glands",,disease_ontology,,DOID:404,http://purl.obolibrary.org/obo/doid#gram-positive_bacterial_infectious_disease,,,,,,,,,,,,,,,,,,gastrointestinal tuberculosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400070,"[""Neuropeptide S receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400070,,,,,,,,,,,,,,,,,,,,,,,,,,,,Neuropeptide S receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000350,"[""THR343 in TXK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000350,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR343 in TXK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100359,"[""Olfactory receptor 2A14""]",,"An olfactory receptor 2A14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R47] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2A14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R47] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100359,,,,https://pharos.nih.gov/idg/targets/Q96R47,,,,,,,,,,,,,OR2A14,OR2A14P|OR2A6,,Q96R47,,,,,,,,Olfactory receptor 2A14,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300140,"[""CLK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300111,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300140,,,,,,,,,,,,,,,,,,,,,,,,,,,,CLK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200596,"[""CMPK1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200596,,,,,,,,,,,,,,,,,,,,,,,,,,,,CMPK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200139,"[""GRIK1 gene""]",,"Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG-&gt;CGG; Q-&gt;R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400416,,,,,,,,"Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG-&gt;CGG; Q-&gt;R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200139,,,,,,,,,,,,,,,,2897,GRIK1,GLUR5,,,,,,,,,,GRIK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000010,"[""CCL27""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000010,,,,,,,,,,,,,,,,,,,,,,,,,,,,CCL27,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4236,"[""carcinosarcoma""]",,A mixed cell type cancer that has_material_basis_in carcinomatous (epithelial tissue) and sarcomatous (connective tissue) components.,false,,,http://purl.obolibrary.org/obo/DOID_154,,,,,,,,A mixed cell type cancer that has_material_basis_in carcinomatous (epithelial tissue) and sarcomatous (connective tissue) components.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4236,,,DOID:4234|DOID:2610|DOID:1971,SNOMEDCT_US_2016_03_01:189808004|SNOMEDCT_US_2016_03_01:63264007|UMLS_CUI:C0007140|NCI:C3730|SNOMEDCT_US_2016_03_01:84427001|MESH:D002296|NCI:C34448|MESH:D018199|UMLS_CUI:C0206627|NCI:C8975|MESH:D018200|UMLS_CUI:C1334603|SNOMEDCT_US_2016_03_01:112684005,mullerian mixed tumor (morphologic abnormality)|malignant mixed mesodermal (mullerian) tumor|Mesodermal mixed tumor (morphologic abnormality)|mullerian mixed tumor|mixed Mesodermal (mullerian) tumor|malignant mixed Mullerian tumor|MMMT|mesodermal mixed tumor,,disease_ontology,,DOID:4236,,,,,,,,,,,,,,,,,,,carcinosarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000074,"[""CDK16 kinase domain""]",,Cyclin-dependent kinase 16; Cell division protein kinase 16; Serine/threonine-protein kinase PCTAIRE-1; FLJ16665; PCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Cyclin-dependent kinase 16; Cell division protein kinase 16; Serine/threonine-protein kinase PCTAIRE-1; FLJ16665; PCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000074,,,,,,,,,,,,,,,,,,,200309,,,,,,,,,CDK16 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4947,"[""cholangiocarcinoma""]",,A bile duct adenocarcinoma that has_material_basis_in bile duct epithelial cells.,false,,,http://purl.obolibrary.org/obo/DOID_4896,,,,,,,,A bile duct adenocarcinoma that has_material_basis_in bile duct epithelial cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4947,,,DOID:5249,MESH:D018281|UMLS_CUI:C0206698|NCI:C4436|ICD10CM:C22.1|SNOMEDCT_US_2016_03_01:312104005|NCI:C8265|SNOMEDCT_US_2016_03_01:70179006|UMLS_CUI:C0280725,adult primary cholangiocellular carcinoma|adult primary Cholangiocarcinoma|cholangiosarcoma,,disease_ontology,,DOID:4947,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,cholangiocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100442,"[""Olfactory receptor 56B1""]",,"An olfactory receptor 56B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 56B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100442,,,,https://pharos.nih.gov/idg/targets/Q8NGI3,,,,,,,,,,,,,OR56B1,OR56B1P,,Q8NGI3,,,,,,,,Olfactory receptor 56B1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000383,"[""THR697 in EPHB1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000383,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR697 in EPHB1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000172,"[""MET443 in MAP3K3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000172,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET443 in MAP3K3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100218,"[""Calcium/calmodulin-dependent protein kinase type ii subunit alpha""]",,"calcium/calmodulin-dependent protein kinase type ii subunit alpha (CAMK2A)  with  no mutation  in a nonphosphorylated state|A calcium/calmodulin-dependent protein kinase type II subunit alpha that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9UQM7] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300172,,,,,,,,"calcium/calmodulin-dependent protein kinase type ii subunit alpha (CAMK2A)  with  no mutation  in a nonphosphorylated state|A calcium/calmodulin-dependent protein kinase type II subunit alpha that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9UQM7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100218,,,,https://pharos.nih.gov/idg/targets/Q9UQM7,,,,,,,,,,,,,CAMK2A,CAMKA|KIAA0968,,Q9UQM7,,,,,,,,Calcium/calmodulin-dependent protein kinase type ii subunit alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80349,"[""gamma-Melanotropin""]",gamma-MSH|gamma-Melanocyte-stimulating hormone,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16137,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,gamma-MSH|gamma-Melanocyte-stimulating hormone,,,CHEBI:80349,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80349,,,,,gamma-Melanotropin,,CHEBI:80349,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300390,"[""CACNA1S subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300333,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300390,,,,,,,,,,,,,,,,,,,,,,,,,,,,CACNA1S subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00000007,"[""Tbio protein""]",,"Tbio are proteins that do not satisfy the Tclin or Tchem criteria, which are annotated with a Gene Ontology Molecular Function or Biological Process with an Experimental Evidence code, or targets with confirmed OMIM phenotype(s), or do not satisfy the Tdark drug target criteria.",false,,,http://www.w3.org/2002/07/owl#Thing,,,,,,,,"Tbio are proteins that do not satisfy the Tclin or Tchem criteria, which are annotated with a Gene Ontology Molecular Function or Biological Process with an Experimental Evidence code, or targets with confirmed OMIM phenotype(s), or do not satisfy the Tdark drug target criteria.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00000007,,,,,,,,,,,,,,,,,,,,,,,,,,,IDG; http://www.nature.com/nrd/posters/druggablegenome/nrd_druggablegenome.pdf,Tbio protein,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100300,"[""Map kinase-activated protein kinase 3""]",,"A MAP kinase-activated protein kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16644] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300289,,,,,,,,"A MAP kinase-activated protein kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16644] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100300,,,,https://pharos.nih.gov/idg/targets/Q16644,,,,,,,,,,,,,MAPKAPK3,,,Q16644,,,,,,,,Map kinase-activated protein kinase 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000265,"[""coagulating gland""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000080,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000265,,,,,,,BrendaTissueOBO,,BTO:0000265,,,,,,,,,,,,,,,,,,,coagulating gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000101,"[""Glucagon-like peptide 2-(3-33)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000101,,,,,,,,,,,,,,,,,,,,,,,,,,,,Glucagon-like peptide 2-(3-33),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3883,"[""Lynch syndrome""]",,"An autosomal dominant disease that is characterized by an increased risk for colon cancer and cancers of the endometrium, ovary, stomach, small intestine, hepatobiliary tract, urinary tract, brain, and skin and has_material_basis_in mutation of mismatch repair genes that increases the risk of many types of cancers.",false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,"An autosomal dominant disease that is characterized by an increased risk for colon cancer and cancers of the endometrium, ovary, stomach, small intestine, hepatobiliary tract, urinary tract, brain, and skin and has_material_basis_in mutation of mismatch repair genes that increases the risk of many types of cancers.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3883,,,DOID:0050586|DOID:3040,OMIM:614331|OMIM:609310|ORDO:144|UMLS_CUI:C0009405|MESH:D003123|OMIM:614385|SNOMEDCT_US_2016_03_01:315058005|OMIM:614337|NCI:C8494|OMIM:120435|OMIM:614350|UMLS_CUI:C1333990|NCI:C120083|OMIM:613244,hereditary nonpolyposis colorectal cancer|Hereditary Defective Mismatch Repair syndrome|HNPCC - hereditary nonpolyposis colon cancer|hereditary non-polyposis colon cancer type 1|COCA 1|hereditary nonpolyposis colorectal neoplasm,,disease_ontology,,DOID:3883,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Lynch syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400439,"[""KCNMB/KCNMB2 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400358,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400439,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNMB/KCNMB2 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_18066,"[""UDP-D-glucose""]","OC[C@H]1OC(OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@H](O)[C@@H](O)[C@@H]1O|HSCJRCZFDFQWRP-RDKQLNKOSA-N|566.055|Uridine 5'-(trihydrogen diphosphate), mono-alpha-d-glucopyranosyl ester|uridinediphosphoglucose|UDP-Glc|UDP-glucose|C15H24N2O17P2|UDPglucose|566.30186|Uridine diphosphate glucose|0|InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1|Uridine 5'-(trihydrogen diphosphate), P'-alpha-D-glucopyranosyl ester",A UDP-sugar having D-glucose as the sugar component.,false,,,http://purl.obolibrary.org/obo/CHEBI_36976,,,,,,,KEGG:C00029|CAS:133-89-1,A UDP-sugar having D-glucose as the sugar component.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:27234|CHEBI:22103|CHEBI:9845|CHEBI:13505|CHEBI:9895|CHEBI:13498,,uridine 5'-[3-D-glucopyranosyl dihydrogen diphosphate]|UDP-D-glucose,,chebi_ontology,"OC[C@H]1OC(OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@H](O)[C@@H](O)[C@@H]1O|HSCJRCZFDFQWRP-RDKQLNKOSA-N|566.055|Uridine 5'-(trihydrogen diphosphate), mono-alpha-d-glucopyranosyl ester|uridinediphosphoglucose|UDP-Glc|UDP-glucose|C15H24N2O17P2|UDPglucose|566.30186|Uridine diphosphate glucose|0|InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1|Uridine 5'-(trihydrogen diphosphate), P'-alpha-D-glucopyranosyl ester",,,CHEBI:18066,,,,,,,,,,,,,,,,,,,,,,,CHEBI:18066,,,,,UDP-D-glucose,,CHEBI:18066,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100624,"[""Olfactory receptor 5G3""]",,"An olfactory receptor 5G3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C626] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5G3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C626] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100624,,,,https://pharos.nih.gov/idg/targets/P0C626,,,,,,,,,,,,,OR5G3,OR5G3P|OR5G6P,,P0C626,,,,,,,,Olfactory receptor 5G3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/UBERON_0000997,"[""mammalian vulva""]",pudendum muliebre|pudendum|pudendum femininum,external genital organs of the female mammal[WP].,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062|http://purl.obolibrary.org/obo/BTO_0003100,,,,,,,http://en.wikipedia.org/wiki/Vulva|http://www.snomedbrowser.com/Codes/Details/265796001|http://linkedlifedata.com/resource/umls/id/C0042993|EFO:0000978|OpenCyc:Mx4rvgAWeJwpEbGdrcN5Y29ycA|CALOHA:TS-1168|GAID:383|UMLS:C0042993|MIAA:0000169|galen:Vulva|EV:0100118|ncithesaurus:Vulva|MAT:0000169|FMA:20462|MA:0000395|MESH:A05.360.319.887|BTO:0003101|VHOG:0001458,external genital organs of the female mammal[WP].,,http://upload.wikimedia.org/wikipedia/commons/d/da/Female_unshaved_genitalia.jpg,,,,,,,,"The external genital organs of the female, including the labia majora, labia minora, clitoris, and vestibule of the vagina. [TFD][VHOG]",,,,,,,,,,,,,,,,,,,,,,,,,,mammalian vulva|puboperineal region|female pudendum|skin of female pudendum|pudendum femininum|vulva|skin of vulva,,uberon,pudendum muliebre|pudendum|pudendum femininum,vulval,,,,,,,,,,,,,,,,,,,,,,,,,UBERON:0000997,,,editor note: todo - add pudendum,,mammalian vulva,,UBERON:0000997,,http://purl.obolibrary.org/obo/uberon.owl,http://purl.obolibrary.org/obo/uberon/core#efo_slim|http://purl.obolibrary.org/obo/uberon/core#uberon_slim,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/UBERON_0000992,"[""female gonad""]",ovaries|ovarium,Ovum-producing female reproductive organ.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000254|http://purl.obolibrary.org/obo/BTO_0003099|http://purl.obolibrary.org/obo/UBERON_0001062,,relationship type change: subclass gonad (TAO:0000413) CHANGED TO: develops_from gonad (UBERON:0000991)[TAO],,,,,http://en.wikipedia.org/wiki/Ovary|http://linkedlifedata.com/resource/umls/id/C0029939|http://www.snomedbrowser.com/Codes/Details/181464007|FBbt:00004865|MESH:A05.360.319.114.630|GAID:367|MA:0000384|UMLS:C0029939|ZFA:0000403|OpenCyc:Mx4rvVi9QJwpEbGdrcN5Y29ycA|BTO:0000975|TAO:0000403|BILA:0000125|EHDAA:8124|XAO:0000258|EV:0100111|FMA:7209|EMAPA:17962|MIAA:0000125|EHDAA2:0001360|VHOG:0000251|ncithesaurus:Ovary|AAO:0000371|BSA:0000080|EFO:0000973|CALOHA:TS-0730,Ovum-producing female reproductive organ.,,http://upload.wikimedia.org/wikipedia/commons/thumb/c/cb/Female_anatomy.png/200px-Female_anatomy.png|http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray589.png,,,,,,,,Either of paired female reproductive organs involved in production of ova and female sex hormones.[AAO]|Female reproductive organ.[TAO],,,,,,,,,,,,,,,,,,,,,,,,,,gonad of female organism genitalia|gonad of genitalia of female organism|gonad of female organism reproductive system|female organism genitalia gonad|female organism genitalia gonada|female organism reproductive system gonad|gonada of reproductive system of female organism|female organism reproductive system gonada|gonad of female reproductive system|gonada of female organism genitalia|gonada of female reproductive system|ovum-producing ovary|reproductive system of female organism gonad|gonada of genitalia of female organism|genitalia of female organism gonad|ovary|reproductive system of female organism gonada|genitalia of female organism gonada|female reproductive system gonad|female reproductive system gonada|gonada of female organism reproductive system|gonad of reproductive system of female organism,,uberon,ovaries|ovarium,ovarian," (...) while it is likely that Urbilateria lacked a complex somatic reproductive system, it is at present impossible to speculate on whether or not it possessed a true gonad, let alone any other somatic adaptations for reproduction (reference 1); Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved (reference 2).[uncertain][VHOG]",,,,,,,,,,,,,,,,,,,,,,,,UBERON:0000992,,,"Ovaries of some kind are found in the female reproductive system of many animals that employ sexual reproduction, including invertebrates. However, they develop in a very different way in most invertebrates than they do in vertebrates, and are not truly homologous. Many of the features found in human ovaries are common to all vertebrates, including the presence of follicular cells, tunica albuginea, and so on. However, many species produce a far greater number of eggs during their lifetime than do humans, so that, in fish and amphibians, there may be hundreds, or even millions of fertile eggs present in the ovary at any given time. In these species, fresh eggs may be developing from the germinal epithelium throughout life. Corpora lutea are found only in mammals, and in some elasmobranch fish; in other species, the remnants of the follicle are quickly resorbed by the ovary. In birds, reptiles, and monotremes, the egg is relatively large, filling the follicle, and distorting the shape of the ovary at maturity. Amphibians and reptiles have no ovarian medulla; the central part of the ovary is a hollow, lymph-filled space. The ovary of teleosts is also often hollow, but in this case, the eggs are shed into the cavity, which opens into the oviduct. Although most normal female vertebrates have two ovaries, this is not the case in all species. In birds and platypuses, the right ovary never matures, so that only the left is functional. In some elasmobranchs, the reverse is true, with only the right ovary fully developing. In the primitive jawless fish, and some teleosts, there is only one ovary, formed by the fusion of the paired organs in the embryo[WP].",,female gonad,,UBERON:0000992,,http://purl.obolibrary.org/obo/uberon.owl,http://purl.obolibrary.org/obo/uberon/core#efo_slim|http://purl.obolibrary.org/obo/uberon/core#organ_slim|http://purl.obolibrary.org/obo/uberon/core#vertebrate_core|http://purl.obolibrary.org/obo/uberon/core#uberon_slim,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/UBERON_0000995,"[""uterus""]",,"a major female hormone-responsive reproductive sex organ of most mammals including humans. One end, the cervix, opens into the vagina, while the other is connected to one or both fallopian tubes, depending on the species. It is within the uterus that the fetus develops during gestation, usually developing completely in placental mammals such as humans and partially in marsupials such as kangaroos and opossums. Two uteruses usually form initially in a female fetus, and in placental mammals they may partially or completely fuse into a single uterus depending on the species. In many species with two uteruses, only one is functional. Humans and other higher primates such as chimpanzees, along with horses, usually have a single completely fused uterus, although in some individuals the uteruses may not have completely fused[WP].",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003099|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,http://en.wikipedia.org/wiki/Uterus|http://www.snomedbrowser.com/Codes/Details/181452004|http://linkedlifedata.com/resource/umls/id/C0042149|galen:Uterus|UMLS:C0042149|GAID:172|CALOHA:TS-1102|VHOG:0001137|BTO:0001424|MA:0000389|MESH:A05.360.319.679|OpenCyc:Mx4rvViojJwpEbGdrcN5Y29ycA|EMAPA:29915|EFO:0000975|MIAA:0000127|MAT:0000127|EV:0100113|ncithesaurus:Uterus|FMA:17558,"a major female hormone-responsive reproductive sex organ of most mammals including humans. One end, the cervix, opens into the vagina, while the other is connected to one or both fallopian tubes, depending on the species. It is within the uterus that the fetus develops during gestation, usually developing completely in placental mammals such as humans and partially in marsupials such as kangaroos and opossums. Two uteruses usually form initially in a female fetus, and in placental mammals they may partially or completely fuse into a single uterus depending on the species. In many species with two uteruses, only one is functional. Humans and other higher primates such as chimpanzees, along with horses, usually have a single completely fused uterus, although in some individuals the uteruses may not have completely fused[WP].",,http://upload.wikimedia.org/wikipedia/commons/6/6a/Female_reproductive_system_lateral_nolabel.png|http://upload.wikimedia.org/wikipedia/commons/thumb/c/cb/Female_anatomy.png/200px-Female_anatomy.png,,,,,,,,The hollow muscular organ in female mammals in which the blastocyst normally becomes embedded and in which the developing embryo and fetus is nourished. Its cavity opens into the vagina below and into a uterine tube on either side. [TFD][VHOG],,,,,,,,,,,,,,,,,,,,,,,,,,,,uberon,,uterine,"An infundibulum, uterine tube, uterus, and vagina also differentiate along the oviducts of eutherian mammals.[well established][VHOG]",,,,,,,,,,,,,,,,,,,,,,,,UBERON:0000995,,,"Most animals that lay eggs, such as birds and reptiles, have an oviduct instead of a uterus. In monotremes, mammals which lay eggs and include the platypus, either the term uterus or oviduct is used to describe the same organ, but the egg does not develop a placenta within the mother and thus does not receive further nourishment after formation and fertilization. Marsupials have two uteruses, each of which connect to a lateral vagina and which both use a third, middle ""vagina"" which functions as the birth canal. Marsupial embryos form a choriovitelline ""placenta"" (which can be thought of as something between a monotreme egg and a ""true"" placenta), in which the egg's yolk sac supplies a large part of the embryo's nutrition but also attaches to the uterine wall and takes nutrients from the mother's bloodstream.",,uterus,,UBERON:0000995,,http://purl.obolibrary.org/obo/uberon.owl,http://purl.obolibrary.org/obo/uberon/core#efo_slim|http://purl.obolibrary.org/obo/uberon/core#organ_slim|http://purl.obolibrary.org/obo/uberon/core#uberon_slim,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300165,"[""MLK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300107,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300165,,,,,,,,,,,,,,,,,,,,,,,,,,,,MLK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300175,"[""PKC family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300175,,,,,,,,,,,,,,,,,,,,,,,,,,,,PKC family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100626,"[""TBC domain-containing protein kinase-like protein""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100626,,,,,,,,,,,,,,,,,TBCK,,,Q8TEA7,,,,,,,,TBC domain-containing protein kinase-like protein,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11816,"[""vitreous syneresis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_9720|http://purl.obolibrary.org/obo/DOID_9799,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11816,,,,ICD10CM:H43.81|ICD9CM:379.21|SNOMEDCT_US_2016_03_01:247090008|SNOMEDCT_US_2016_03_01:60189009|UMLS_CUI:C0155366,Vitreous degeneration,,disease_ontology,,DOID:11816,,,,,,,,,,,,,,,,,,,vitreous syneresis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11819,"[""ureter cancer""]",,A urinary system cancer that is located_in the ureter.,false,,,http://purl.obolibrary.org/obo/DOID_3996,,,,,,,,A urinary system cancer that is located_in the ureter.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11819,,,,OMIM:191600|MESH:D014516|SNOMEDCT_US_2016_03_01:363458004|NCI:C7543|ICD9CM:189.2|SNOMEDCT_US_2016_03_01:94121005|UMLS_CUI:C0153619|ICD10CM:C66|SNOMEDCT_US_2016_03_01:154543003,malignant tumour of ureter|malignant ureteral tumor,,disease_ontology,,DOID:11819,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,ureter cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BFO_0000019,"[""quality""]",,,false,,,http://www.w3.org/2002/07/owl#Thing,,,Quality,quality,,,,,,,,,,,,"a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001])",the color of a tomato|the ambient temperature of this portion of air|the length of the circumference of your waist|the mass of this piece of gold.|the shape of your nostril|the shape of your nose,,,,,(forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001] |(forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001] ,"If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001])",,,,,,,,,,,,,,,,,,,,,,,,,,,BFO:0000019,,,,,,,,,,,,,,,,,,,,,,,,,,,http://purl.obolibrary.org/obo/bfo.owl,quality,,,,http://purl.obolibrary.org/obo/bfo.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400242,"[""VEGFR family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400242,,,,,,,,,,,,,,,,,,,,,,,,,,,,VEGFR family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001741,"[""incisor""]",,"A tooth adapted for cutting or gnawing, located at the front of the mouth along the apex of the dental arch.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000397,,,,,,,,"A tooth adapted for cutting or gnawing, located at the front of the mouth along the apex of the dental arch.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001741,,,,,,,BrendaTissueOBO,,BTO:0001741,,,,,,,,,,,,,,,,,,,incisor,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200255,"[""GRIN3A gene""]",,"This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400453,,,,,,,,"This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200255,,,,,,,,,,,,,,,,116443,GRIN3A,KIAA1973,,,,,,,,,,GRIN3A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400215,"[""SLOB family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400215,,,,,,,,,,,,,,,,,,,,,,,,,,,,SLOB family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300057,"[""Chemokine receptor-like""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300057,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chemokine receptor-like,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200193,"[""IRAK4 gene""]",,"This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400166,,,,,,,,"This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200193,,,,,,,,,,,,,,,,51135,IRAK4,,,,,,,,,,,IRAK4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000493,"[""gall bladder""]",,"A small, pear-shaped muscular sac, located under the right lobe of the liver, in which bile secreted by the liver is stored until needed by the body for digestion.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062|http://purl.obolibrary.org/obo/BTO_0000123,,,,,,,,"A small, pear-shaped muscular sac, located under the right lobe of the liver, in which bile secreted by the liver is stored until needed by the body for digestion.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000493,,,,,,,BrendaTissueOBO,gallbladder,BTO:0000493,,,,,,,,,,,,,,,,,,,gall bladder,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300273,"[""HIPK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300150,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300273,,,,,,,,,,,,,,,,,,,,,,,,,,,,HIPK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200723,"[""OXER1 gene""]",,"An oxoeicosanoid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDS5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"An oxoeicosanoid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDS5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200723,,,,,,,,,,,,,,,,165140,OXER1,GPR170|TG1019,,,,,,,,,,OXER1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200419,"[""OR52E6 gene""]",,"An olfactory receptor 52E6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 52E6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200419,,,,,,,,,,,,,,,,390078,OR52E6,,,,,,,,,,,OR52E6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400585,"[""TRPM3 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400483,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400585,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPM3 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100101,"[""Fxyd domain-containing ion transport regulator 3""]",,"An FXYD domain-containing ion transport regulator 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14802] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300348,,,,,,,,"An FXYD domain-containing ion transport regulator 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14802] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100101,,,,https://pharos.nih.gov/idg/targets/Q14802,,,,,,,,,,,,,FXYD3,MAT8|PLML,,Q14802,,,,,,,,Fxyd domain-containing ion transport regulator 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_162,"[""cancer""]",,"A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis.",false,,,http://purl.obolibrary.org/obo/DOID_14566,,,,,,,,"A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:162,,,,NCI:C9305|SNOMEDCT_US_2016_03_01:154433003|SNOMEDCT_US_2016_03_01:188482002|ICD10CM:C80|SNOMEDCT_US_2016_03_01:38807002|SNOMEDCT_US_2016_03_01:269623003|UMLS_CUI:C0006826|SNOMEDCT_US_2016_03_01:269513004|SNOMEDCT_US_2016_03_01:154577008|SNOMEDCT_US_2016_03_01:269626006|SNOMEDCT_US_2016_03_01:188475001|SNOMEDCT_US_2016_03_01:190150006|ICD10CM:C80.1|ICD9CM:199|SNOMEDCT_US_2016_03_01:154432008|SNOMEDCT_US_2016_03_01:269634000|SNOMEDCT_US_2016_03_01:187597000|MESH:D009369|SNOMEDCT_US_2016_03_01:363346000,malignant tumor |malignant neoplasm|primary cancer,,disease_ontology,,DOID:162,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,Updating out dated UMLS CUI.,,cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_16,"[""integumentary system disease""]",,A disease of anatomical entity that is located_in the integumentary system comprising the skin and its appendages.,false,,,http://purl.obolibrary.org/obo/DOID_7,,,,,,,,A disease of anatomical entity that is located_in the integumentary system comprising the skin and its appendages.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:16,,,,,,,disease_ontology,,DOID:16,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,integumentary system disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_161,"[""keratosis""]",,A skin disease characterized_by growth of keratin on the skin or mucous membranes.,false,,,http://purl.obolibrary.org/obo/DOID_37,,,,,,,,A skin disease characterized_by growth of keratin on the skin or mucous membranes.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:161,,,,SNOMEDCT_US_2016_03_01:254666005|NCI:C34747|UMLS_CUI:C0022593|MESH:D007642,,,disease_ontology,,DOID:161,,,,,,,,,,,,,,,,,,,keratosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_169,"[""neuroendocrine tumor""]",,An endocrine gland cancer that has_material_basis_in neuroendocrine cells.,false,,,http://purl.obolibrary.org/obo/DOID_170,,,,,,,,An endocrine gland cancer that has_material_basis_in neuroendocrine cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:169,,,,UMLS_CUI:C0206754|SNOMEDCT_US_2016_03_01:255046005|NCI:C3809|MESH:D018358|ICD9CM:209|SNOMEDCT_US_2016_03_01:128928004|ICD10CM:D3A.8|ICD9CM:209-209.99,neuroendocrine neoplasm,,disease_ontology,,DOID:169,,,,,,,,,,,,,,,,,,,neuroendocrine tumor,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100791,"[""Taste receptor type 2 member 50""]",,"A taste receptor type 2 member 50 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59544] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300014,,,,,,,,"A taste receptor type 2 member 50 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59544] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100791,,,,https://pharos.nih.gov/idg/targets/P59544,,,,,,,,,,,,,TAS2R50,,,P59544,,,,,,,,Taste receptor type 2 member 50,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200227,"[""KHK gene""]",,"This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03491032,,,,,,,,"This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200227,,,,,,,,,,,,,,,,3795,KHK,,,,,,,,,,,KHK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002733,"[""embryonic kidney cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000669,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002733,,,,,,,BrendaTissueOBO,,BTO:0002733,,,,,,,,,,,,,,,,,,,embryonic kidney cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000222,"[""KIT-autoinhibited kinase domain""]",,V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; C-Kit; KIT; PBT; SCFR,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; C-Kit; KIT; PBT; SCFR,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000222,,,,,,,,,,,,,,,,,,,200474,,,,,,,,,KIT-autoinhibited kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001011,"[""cerebellar Purkinje cell""]",,Large neurons in the cerebellar cortex that have piriform cell bodies in the Purkinje layer (the stratum purkinjense cerebelli) and large branching dendrite trees going through the outer (molecular) layer towards the surface.,false,,,http://purl.obolibrary.org/obo/BTO_0000938|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Large neurons in the cerebellar cortex that have piriform cell bodies in the Purkinje layer (the stratum purkinjense cerebelli) and large branching dendrite trees going through the outer (molecular) layer towards the surface.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001011,,,,,,,BrendaTissueOBO,Purkinje neuron|Purkinje cell,BTO:0001011,,,,,,,,,,,,,,,,,,,cerebellar Purkinje cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002745,"[""CAPAN-2 cell""]",,Human pancreas adenocarcinoma cell line; established from the tumor of a 56-year-old Caucasian man with pancreas adenocarcinoma in 1975.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001521,,,,,,,,Human pancreas adenocarcinoma cell line; established from the tumor of a 56-year-old Caucasian man with pancreas adenocarcinoma in 1975.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002745,,,,,,,BrendaTissueOBO,,BTO:0002745,,,,,,,,,,,,,,,,,,,CAPAN-2 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200215,"[""GPR88 gene""]",,"A G-protein coupled receptor 88 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9GZN0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 88 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9GZN0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200215,,,,,,,,,,,,,,,,54112,GPR88,STRG,,,,,,,,,,GPR88 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5304,"[""ovarian clear cell adenocarcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3713,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5304,,,,UMLS_CUI:C1518693|NCI:C40078,,,disease_ontology,,DOID:5304,,,,,,,,,,,,,,,,,,,ovarian clear cell adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000097,"[""CSNK1A1 kinase domain""]",,"Casein kinase 1, alpha 1; CK1; CK1a; CSNK1A1; HLCDGP1; PRO2975",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Casein kinase 1, alpha 1; CK1; CK1a; CSNK1A1; HLCDGP1; PRO2975",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000097,,,,,,,,,,,,,,,,,,,200096,,,,,,,,,CSNK1A1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100613,"[""Nucleoside diphosphate kinase A""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100613,,,,,,,,,,,,,,,,,NME1,,,P15531,,,,,,,,Nucleoside diphosphate kinase A,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200223,"[""KCNK13 gene""]",,"Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a potassium channel containing two pore-forming domains. This protein is an open channel that can be stimulated by arachidonic acid and inhibited by the anesthetic halothane. [provided by RefSeq, Jul 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_01400359,,,,,,,,"Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a potassium channel containing two pore-forming domains. This protein is an open channel that can be stimulated by arachidonic acid and inhibited by the anesthetic halothane. [provided by RefSeq, Jul 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200223,,,,,,,,,,,,,,,,56659,KCNK13,,,,,,,,,,,KCNK13 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001099,"[""blastocyst""]",,The modified blastula of a placental mammal.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000128,,,,,,,,The modified blastula of a placental mammal.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001099,,,,,,,BrendaTissueOBO,,BTO:0001099,,,,,,,,,,,,,,,,,,,blastocyst,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200590,"[""IP6K2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200590,,,,,,,,,,,,,,,,,,,,,,,,,,,,IP6K2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3612,"[""retinitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5679,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3612,,,,ICD10CM:H30.9|NCI:C115993|SNOMEDCT_US_2016_03_01:193450000|UMLS_CUI:C0035333|SNOMEDCT_US_2016_03_01:35426003|MESH:D012173|SNOMEDCT_US_2016_03_01:399463004,,,disease_ontology,,DOID:3612,,,,,,,,,,,,,,,,,,,retinitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400178,"[""RSK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400178,,,,,,,,,,,,,,,,,,,,,,,,,,,,RSK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400046,"[""Galanin receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400046,,,,,,,,,,,,,,,,,,,,,,,,,,,,Galanin receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200252,"[""MC3R gene""]",,"A melanocortin receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41968] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400021,,,,,,,,"A melanocortin receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41968] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200252,,,,,,,,,,,,,,,,4159,MC3R,,,,,,,,,,,MC3R gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004371,"[""medial vestibular nucleus""]",,The one of the four vestibular nuclei on each side of the medulla oblongata that sends ascending fibers to the oculomotor and trochlear nuclei in the cerebrum on the opposite side of the brain and sends descending fibers down both sides of the spinal cord to synapse with motor neurons of the ventral roots.,false,,,http://purl.obolibrary.org/obo/BTO_0004368|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The one of the four vestibular nuclei on each side of the medulla oblongata that sends ascending fibers to the oculomotor and trochlear nuclei in the cerebrum on the opposite side of the brain and sends descending fibers down both sides of the spinal cord to synapse with motor neurons of the ventral roots.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004371,,,,,,,BrendaTissueOBO,,BTO:0004371,,,,,,,,,,,,,,,,,,,medial vestibular nucleus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10493,"[""adrenal cortical hypofunction""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3952,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10493,,,,SNOMEDCT_US_2016_03_01:68588005|NCI:C26691|SNOMEDCT_US_2016_03_01:154707007|SNOMEDCT_US_2016_03_01:386584007|SNOMEDCT_US_2016_03_01:190527008|UMLS_CUI:C0405580|SNOMEDCT_US_2016_03_01:267398003|SNOMEDCT_US_2016_03_01:267483004|ICD9CM:255.4,Adrenal Cortical Insufficiency|Corticoadrenal insufficiency,,disease_ontology,,DOID:10493,,,,,,,,,,,,,,,,,,,adrenal cortical hypofunction,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100264,"[""Serine/threonine-protein kinase lats1""]",,"serine/threonine-protein kinase lats1 (LATS1)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase LATS1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95835] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300181,,,,,,,,"serine/threonine-protein kinase lats1 (LATS1)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase LATS1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95835] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100264,,,,https://pharos.nih.gov/idg/targets/O95835,,,,,,,,,,,,,LATS1,WARTS,,O95835,,,,,,,,Serine/threonine-protein kinase lats1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100241,"[""Lysophosphatidic acid receptor 4""]",,"A lysophosphatidic acid receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99677] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302007,,,,,,,,"A lysophosphatidic acid receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99677] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100241,,,,https://pharos.nih.gov/idg/targets/Q99677,,,,,,,,,,,,,LPAR4,GPR23|LPA4|P2RY9,,Q99677,,,,,,,,Lysophosphatidic acid receptor 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200291,"[""SCN2A gene""]",,"Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several seizure disorders. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400465,,,,,,,,"Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several seizure disorders. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200291,,,,,,,,,,,,,,,,6326,SCN2A,NAC2|SCN2A1|SCN2A2,,,,,,,,,,SCN2A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80326,"[""Neuropeptide FF""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG COMPOUND:C16112,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80326,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80326,,,,,Neuropeptide FF,,CHEBI:80326,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200643,"[""OR5P3 gene""]",,"An olfactory receptor 5P3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZ94] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5P3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZ94] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200643,,,,,,,,,,,,,,,,120066,OR5P3,,,,,,,,,,,OR5P3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200208,"[""CSNK1A1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400170,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200208,,,,,,,,,,,,,,,,1452,CSNK1A1,,,,,,,,,,,CSNK1A1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400004,"[""Class C metabotropic glutamate/pheromone gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400001,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400004,,,,,,,,,,,,,,,,,,,,,,,,,,,,Class C metabotropic glutamate/pheromone gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217572,"[""NR4A3 gene""]",,"This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_00217475,,,,,,,,"This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217572,,,,,,,,,,,,,,,,8013,NR4A3,CSMF,,,,,,,,,,NR4A3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00000003,"[""Endogenous ligand role""]",,"An Endogenous ligand is a molecule like protein, lipid, nucleoside, etc., that is produced in the body and that attaches (binds) to another protein called a receptor; receptor proteins have specific sites into which the ligands fit like keys into locks. Endogenous ligands not those that are introduced into the body, such as certain drugs.",false,,,http://purl.obolibrary.org/obo/CHEBI_24432,,,,,,,,"An Endogenous ligand is a molecule like protein, lipid, nucleoside, etc., that is produced in the body and that attaches (binds) to another protein called a receptor; receptor proteins have specific sites into which the ligands fit like keys into locks. Endogenous ligands not those that are introduced into the body, such as certain drugs.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00000003,,,,,,,,,,,,,,,,,,,,,,,,,,,https://ghr.nlm.nih.gov/primer/genefamily/endogenousligands,Endogenous ligand role,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002482,"[""gonadotrophic cell""]",,"A basophil of the adenohypophysis whose granules secrete follicle-stimulating hormone and luteinizing hormone. Called also delta basophil, delta cell, and gonadotrope or gonadotropic cell.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000129,,,,,,,,"A basophil of the adenohypophysis whose granules secrete follicle-stimulating hormone and luteinizing hormone. Called also delta basophil, delta cell, and gonadotrope or gonadotropic cell.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002482,,,,,,,BrendaTissueOBO,gonadotrope cell|delta cell|delta basophil|gonadotropic,BTO:0002482,,,,,,,,,,,,,,,,,,,gonadotrophic cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_811,"[""lipodystrophy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_37,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:811,,,,SNOMEDCT_US_2016_03_01:190789006|NCI:C97093|SNOMEDCT_US_2016_03_01:71325002|UMLS_CUI:C0023787|ICD9CM:272.6|SNOMEDCT_US_2016_03_01:190790002|ICD10CM:E88.1|MESH:D008060,,,disease_ontology,,DOID:811,,,,,,,,,,,,,,,,,,,lipodystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_813,"[""septic arthritis""]",,An arthritis that involves infection by a pathogen located_in joint.,false,,,http://purl.obolibrary.org/obo/DOID_848,,,,,,,,An arthritis that involves infection by a pathogen located_in joint.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:813,,,DOID:12314|DOID:2002|DOID:14519|DOID:2003|DOID:812|DOID:1683|DOID:10920,ICD10CM:M00.9|UMLS_CUI:C0157848|ICD9CM:711.97|SNOMEDCT_US_2016_03_01:201592000|ICD9CM:711.92|ICD9CM:711.96|SNOMEDCT_US_2016_03_01:371412008|UMLS_CUI:C0157847|MESH:D001170|ICD9CM:711.91|UMLS_CUI:C0157849|ICD9CM:711.94|SNOMEDCT_US_2016_03_01:196415003|SNOMEDCT_US_2016_03_01:201595003|SNOMEDCT_US_2016_03_01:372938004|SNOMEDCT_US_2016_03_01:48548006|ICD10CM:M00|SNOMEDCT_US_2016_03_01:201597006|ICD9CM:711.95|ICD9CM:711.93|SNOMEDCT_US_2016_03_01:201598001|SNOMEDCT_US_2016_03_01:201596002|SNOMEDCT_US_2016_03_01:201593005|SNOMEDCT_US_2016_03_01:239776008|UMLS_CUI:C0157845|UMLS_CUI:C0157846|SNOMEDCT_US_2016_03_01:201455003|SNOMEDCT_US_2016_03_01:396234004|SNOMEDCT_US_2016_03_01:55388007|SNOMEDCT_US_2016_03_01:156470005|SNOMEDCT_US_2016_03_01:201471003|NCI:C26700|SNOMEDCT_US_2016_03_01:83486002|ICD9CM:711.0|ICD9CM:711.90|SNOMEDCT_US_2016_03_01:201599009|SNOMEDCT_US_2016_03_01:201594004|SNOMEDCT_US_2016_03_01:201623005|UMLS_CUI:C0157843|ICD9CM:711.9|UMLS_CUI:C0157844|SNOMEDCT_US_2016_03_01:201591007|SNOMEDCT_US_2016_03_01:372939007|SNOMEDCT_US_2016_03_01:428437005|UMLS_CUI:C0003869,infectious arthritis,,disease_ontology,,DOID:813,,,,,,,,,,,,,,,,,,,septic arthritis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100216,"[""Adhesion G protein-coupled receptor G3""]",,"A G-protein coupled receptor 97 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86Y34] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,"A G-protein coupled receptor 97 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86Y34] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100216,,,,https://pharos.nih.gov/idg/targets/Q86Y34,,,,,,,,,,,,,GPR97,ADGRG3|PGR26,,Q86Y34,,,,,,,,Adhesion G protein-coupled receptor G3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3748,"[""esophagus squamous cell carcinoma""]",,An esophageal carcinoma that derives_from epithelial squamous cells located_in the esophagus.,false,,,http://purl.obolibrary.org/obo/DOID_1107|http://purl.obolibrary.org/obo/DOID_1749,,,,,,,,An esophageal carcinoma that derives_from epithelial squamous cells located_in the esophagus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3748,,,,SNOMEDCT_US_2016_03_01:276804009|UMLS_CUI:C0279626|NCI:C4024|MESH:C562729,SCC of esophagus|squamous cell carcinoma of esophagus (disorder),,disease_ontology,squamous cell carcinoma of esophagus,DOID:3748,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,esophagus squamous cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13328,"[""diabetic cataract""]",,,false,,,http://purl.obolibrary.org/obo/DOID_83,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13328,,,,UMLS_CUI:C0011876|SNOMEDCT_US_2016_03_01:154678005|ICD9CM:366.41|SNOMEDCT_US_2016_03_01:155129005|SNOMEDCT_US_2016_03_01:267722005|SNOMEDCT_US_2016_03_01:43959009|SNOMEDCT_US_2016_03_01:267471001,Cataract - diabetic,,disease_ontology,,DOID:13328,,,,,,,,,,,,,,,,,,,diabetic cataract,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100289,"[""Mitogen-activated protein kinase kinase kinase 7""]",,A mitogen-activated protein kinase kinase kinase 7 that is encoded in the genome of human. [Reactome:REACT_7270] |mitogen-activated protein kinase kinase kinase 7 (TAK1)  with  no mutation  in a nonphosphorylated state,false,,,http://www.drugtargetontology.org/dto/DTO_03300286,,,,,,,,A mitogen-activated protein kinase kinase kinase 7 that is encoded in the genome of human. [Reactome:REACT_7270] |mitogen-activated protein kinase kinase kinase 7 (TAK1)  with  no mutation  in a nonphosphorylated state,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100289,,,,https://pharos.nih.gov/idg/targets/O43318,,,,,,,,,,,,,MAP3K7,TAK1,,O43318,,,,,,,,Mitogen-activated protein kinase kinase kinase 7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4029,"[""gastritis""]",,A stomach disease that is an inflammation of the lining of the stomach.,false,,,http://purl.obolibrary.org/obo/DOID_76,,,,,,,,A stomach disease that is an inflammation of the lining of the stomach.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4029,,,DOID:9190|DOID:4032|DOID:8697|DOID:8845,UMLS_CUI:C0017152|SNOMEDCT_US_2016_03_01:196743006|MESH:D005756|SNOMEDCT_US_2016_03_01:4556007|SNOMEDCT_US_2016_03_01:155711008|SNOMEDCT_US_2016_03_01:266503008|ICD10CM:K29.7|SNOMEDCT_US_2016_03_01:235653009|NCI:C26780,Erosive gastropathy|acute gastric mucosal erosion|Erosive Gastritis,,disease_ontology,,DOID:4029,,,,,,,,,,,,,,,,,,,gastritis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300402,"[""CNGA1 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300343,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300402,,,,,,,,,,,,,,,,,,,,,,,,,,,,CNGA1 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000167,"[""FLT3(ITD) kinase domain""]",,Fms-related tyrosine kinase 3; CD135; FLK2; FLK-2; FLT3; FLT-3; Ly72; STK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Fms-related tyrosine kinase 3; CD135; FLK2; FLK-2; FLT3; FLT-3; Ly72; STK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000167,,,,,,,,,,,,,,,,,,,200171,,,,,,,,,FLT3(ITD) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000408,"[""SIK1 kinase domain""]",,Serine/threonine-protein kinase SIK1; salt-inducible kinase 1; MSK; SIK; SIK1; SNF1LK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase SIK1; salt-inducible kinase 1; MSK; SIK; SIK1; SNF1LK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000408,,,,,,,,,,,,,,,,,,,200410,,,,,,,,,SIK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100648,"[""Olfactory receptor 5V1""]",,"An olfactory receptor 5V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UGF6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UGF6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100648,,,,https://pharos.nih.gov/idg/targets/Q9UGF6,,,,,,,,,,,,,OR5V1,,,Q9UGF6,,,,,,,,Olfactory receptor 5V1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200278,"[""NPFFR1 gene""]",,"A neuropeptide FF receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9GZQ6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400069,,,,,,,,"A neuropeptide FF receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9GZQ6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200278,,,,,,,,,,,,,,,,64106,NPFFR1,GPR147|NPFF1,,,,,,,,,,NPFFR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200191,"[""GPR33 gene""]",,"A G-protein coupled receptor 33 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q49SQ1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400057,,,,,,,,"A G-protein coupled receptor 33 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q49SQ1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200191,,,,,,,,,,,,,,,,2856,GPR33,,,,,,,,,,,GPR33 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100566,"[""Olfactory receptor 4A5""]",,"An olfactory receptor 4A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH83] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH83] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100566,,,,https://pharos.nih.gov/idg/targets/Q8NH83,,,,,,,,,,,,,OR4A5,,,Q8NH83,,,,,,,,Olfactory receptor 4A5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100555,"[""Serine/threonine-protein kinase ulk1""]",,"serine/threonine-protein kinase ulk1 (ULK1)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase ULK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75385] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300228,,,,,,,,"serine/threonine-protein kinase ulk1 (ULK1)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase ULK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75385] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100555,,,,https://pharos.nih.gov/idg/targets/O75385,,,,,,,,,,,,,ULK1,KIAA0722,,O75385,,,,,,,,Serine/threonine-protein kinase ulk1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200232,"[""HRH3 gene""]",,"A histamine H3 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5N1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400061,,,,,,,,"A histamine H3 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5N1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200232,,,,,,,,,,,,,,,,11255,HRH3,GPCR97,,,,,,,,,,HRH3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004475,"[""MEL cell""]",,Murine erythroleukemia cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000846,,,,,,,,Murine erythroleukemia cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004475,Marion,2010-02-04T10:43:43Z,,,,,BrendaTissueOBO,,BTO:0004475,,,,,,,,,,,,,,,,,,,MEL cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100337,"[""Transient receptor potential cation channel subfamily V member 5""]",,"A transient receptor potential cation channel subfamily V member 5 that is encoded in the genome of human. [PRO:HJD, UniProtKB:Q9NQA5] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300594,,,,,,,,"A transient receptor potential cation channel subfamily V member 5 that is encoded in the genome of human. [PRO:HJD, UniProtKB:Q9NQA5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100337,,,,https://pharos.nih.gov/idg/targets/Q9NQA5,,,,,,,,,,,,,TRPV5,ECAC1,,Q9NQA5,,,,,,,,Transient receptor potential cation channel subfamily V member 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217542,"[""RORC gene""]",,"The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_00217464,,,,,,,,"The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217542,,,,,,,,,,,,,,,,6097,RORC,NR1F3|RORG|RZRG,,,,,,,,,,RORC gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8557,"[""oropharynx cancer""]",,A pharynx cancer that is located_in the  oropharynx.,false,,,http://purl.obolibrary.org/obo/DOID_0060119,,,,,,,,A pharynx cancer that is located_in the  oropharynx.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8557,,,DOID:8949|DOID:8851|DOID:8684|DOID:9168,SNOMEDCT_US_2016_03_01:187686007|ICD9CM:146.5|ICD9CM:146|SNOMEDCT_US_2016_03_01:187688008|SNOMEDCT_US_2016_03_01:187691008|ICD9CM:146.7|SNOMEDCT_US_2016_03_01:363392002|SNOMEDCT_US_2016_03_01:93933005|ICD10CM:C10.3|SNOMEDCT_US_2016_03_01:373653002|ICD9CM:146.6|UMLS_CUI:C0153390|ICD10CM:C10.9|UMLS_CUI:C0153388|UMLS_CUI:C0153382|ICD9CM:146.9|SNOMEDCT_US_2016_03_01:93971002|ICD10CM:C10.8|ICD10CM:C10|NCI:C7398|ICD10CM:C10.2|SNOMEDCT_US_2016_03_01:448868009|UMLS_CUI:C0153389,oropharyngeal cancer|malignant tumour of mesopharynx (disorder)|malignant neoplasm of junctional region of oropharynx|Oropharyngeal carcinoma|malignant tumor of oropharynx (disorder)|malignant neoplasm of lateral wall of oropharynx|malignant neoplasm of posterior wall of oropharynx|malignant tumor of posterior wall of oropharynx (disorder)|primary malignant neoplasm of lateral wall of oropharynx|malignant Oropharyngeal tumor|malignant neoplasm of oropharynx,,disease_ontology,,DOID:8557,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,oropharynx cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000394,"[""aorta endothelium""]",,Simple squamous epithelium which lines the lumen side of the blood vessel.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001853,,,,,,,,Simple squamous epithelium which lines the lumen side of the blood vessel.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000394,,,,,,,BrendaTissueOBO,aortic endothelium,BTO:0000394,,,,,,,,,,,,,,,,,,,aorta endothelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100074,"[""H(+)/Cl(-) exchange transporter 3""]",,"An H(+)/Cl(-) exchange transporter 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51790] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300397,,,,,,,,"An H(+)/Cl(-) exchange transporter 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51790] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100074,,,,https://pharos.nih.gov/idg/targets/P51790,,,,,,,,,,,,,CLCN3,,,P51790,,,,,,,,H(+)/Cl(-) exchange transporter 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9942,"[""lymph node disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_75,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9942,,,,SNOMEDCT_US_2016_03_01:76616003|UMLS_CUI:C0272394|NCI:C35346,,,disease_ontology,,DOID:9942,,,,,,,,,,,,,,,,,,,lymph node disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1085,"[""Edwards syndrome""]",,OMIM mapping confirmed by DO. [LS].,false,,,http://purl.obolibrary.org/obo/DOID_0080014,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1085,,,,ICD9CM:758.2|ICD10CM:Q91.3|UMLS_CUI:C0152096|MESH:C580500|SNOMEDCT_US_2016_03_01:205626006|SNOMEDCT_US_2016_03_01:254265001|SNOMEDCT_US_2016_03_01:51500006|SNOMEDCT_US_2016_03_01:157022000|NCI:C101362,trisomy 18|Complete trisomy 18 syndrome (disorder)|E3 Trisomy,,disease_ontology,,DOID:1085,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,Edwards syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10854,"[""salivary gland disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_403,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10854,,,DOID:12898,ICD9CM:527.8|UMLS_CUI:C0029773,Salivary gland disease|Non-neoplastic Salivary gland disease,,disease_ontology,,DOID:10854,,,,,,,,,,,,,,,,,,,salivary gland disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1242,"[""globe disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5614,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1242,,,,SNOMEDCT_US_2016_03_01:194638007|ICD9CM:360.29|ICD10CM:H44.39|UMLS_CUI:C0154780,,,disease_ontology,,DOID:1242,,,,,,,,,,,,,,,,,,,globe disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1756,"[""facial nerve disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5656,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1756,,,,SNOMEDCT_US_2016_03_01:193097005|MESH:D005155|NCI:C27594|SNOMEDCT_US_2016_03_01:422426003|SNOMEDCT_US_2016_03_01:155069009|ICD10CM:G51|ICD10CM:G51.9|SNOMEDCT_US_2016_03_01:267704007|UMLS_CUI:C0015464|SNOMEDCT_US_2016_03_01:90039006|ICD9CM:351.9|SNOMEDCT_US_2016_03_01:230543003|ICD9CM:351|SNOMEDCT_US_2016_03_01:155071009,,,disease_ontology,,DOID:1756,,,,,,,,,,,,,,,,,,,facial nerve disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200788,"[""TAS2R42 gene""]",,"A taste receptor type 2 member 42 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7RTR8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400014,,,,,,,,"A taste receptor type 2 member 42 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7RTR8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200788,,,,,,,,,,,,,,,,353164,TAS2R42,TAS2R55,,,,,,,,,,TAS2R42 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100353,"[""Olfactory receptor 14C36""]",,"An olfactory receptor 14C36 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHC7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 14C36 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHC7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100353,,,,https://pharos.nih.gov/idg/targets/Q8NHC7,,,,,,,,,,,,,OR14C36,OR5BF1,,Q8NHC7,,,,,,,,Olfactory receptor 14C36,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100150,"[""Probable g-protein coupled receptor 146""]",,"A G-protein coupled receptor 146 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96CH1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 146 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96CH1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100150,,,,https://pharos.nih.gov/idg/targets/Q96CH1,,,,,,,,,,,,,GPR146,PGR8,,Q96CH1,,,,,,,,Probable g-protein coupled receptor 146,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9500,"[""leukocyte disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_74,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9500,,,,SNOMEDCT_US_2016_03_01:154829002|SNOMEDCT_US_2016_03_01:54097007|ICD10CM:D72.9|MESH:D007960|ICD9CM:288.9|UMLS_CUI:C0023510|ICD9CM:288|SNOMEDCT_US_2016_03_01:191369001,,,disease_ontology,,DOID:9500,,,,,,,,,,,,,,,,,,,leukocyte disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001295,"[""cranium""]",,1: The skull of a vertebrate. 2: The portion of the skull enclosing the brain; the braincase.,false,,,http://purl.obolibrary.org/obo/UBERON_0001474|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000140,,,,,,,,1: The skull of a vertebrate. 2: The portion of the skull enclosing the brain; the braincase.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001295,,,,,,,BrendaTissueOBO,skull|skeletal system of head,BTO:0001295,,,,,,,,,,,,,,,,,,,cranium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050548,"[""hereditary sensory neuropathy""]",,"A neuropathy characterized by congenital insensitivity to pain resulting in ulceration to the fingers, tongue, lips, and other distal appendages.",false,,,http://purl.obolibrary.org/obo/DOID_870,,,,,,,,"A neuropathy characterized by congenital insensitivity to pain resulting in ulceration to the fingers, tongue, lips, and other distal appendages.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050548,,,,OMIM:256800|OMIM:616488|OMIM:256860|OMIM:613640|OMIM:615548|OMIM:613115|OMIM:614653|OMIM:614213|OMIM:614116|OMIM:310470|OMIM:162400|OMIM:608654|OMIM:613708|OMIM:201300|OMIM:615632|OMIM:608088,"congenital insensitivity to pain|hereditary sensory and autonomic neuropathy|familial dysautonomia, type II",,disease_ontology,,DOID:0050548,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,hereditary sensory neuropathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050544,"[""hypermethioninemia""]",,"An amino acid metabolic disorder that involves an excess of the amino acid methionine, in the blood. This condition can occur when methionine is not broken down properly in the body.",false,,,http://purl.obolibrary.org/obo/DOID_9252,,,,,,,,"An amino acid metabolic disorder that involves an excess of the amino acid methionine, in the blood. This condition can occur when methionine is not broken down properly in the body.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050544,,,,ORDO:289290|OMIM:614300|OMIM:613752,hypermethioninemia with s-adenosylhomocysteine hydrolase deficiency,,disease_ontology,,DOID:0050544,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,hypermethioninemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050545,"[""visceral heterotaxy""]",,A physical disorder characterized by the abnormal distribution of the major visceral organs within the chest and abdomen.,false,,,http://purl.obolibrary.org/obo/DOID_0080015,,,,,,,,A physical disorder characterized by the abnormal distribution of the major visceral organs within the chest and abdomen.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050545,,,,OMIM:606325|ORDO:450|OMIM:605376|OMIM:613751|OMIM:306955|OMIM:614779,situs ambiguus|heterotaxia,,disease_ontology,,DOID:0050545,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,visceral heterotaxy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200508,"[""STK4 gene""]",,"The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400317,,,,,,,,"The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200508,,,,,,,,,,,,,,,,6789,STK4,KRS2|MST1,,,,,,,,,,STK4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001248,"[""T-47D cell""]",,"Human ductal breast carcinoma ductal cell line. Morphology: epithelial-likeSpecies: human female 54 years old; Tissue: breast; Tumor: carcinoma, ductal; Derived from: T47, originally derived from pleural effusion.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Human ductal breast carcinoma ductal cell line. Morphology: epithelial-likeSpecies: human female 54 years old; Tissue: breast; Tumor: carcinoma, ductal; Derived from: T47, originally derived from pleural effusion.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001248,,,,,,,BrendaTissueOBO,T47D cell|T47-D cell,BTO:0001248,,,,,,,,,,,,,,,,,,,T-47D cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002813,"[""gubernaculum testis""]",,"The fetal ligament attached to the inferior end of the epididymis and testis and, at its other end, to the bottom of the scrotum; it is present during, and is thought to guide, the descent of the testis into the scrotum and then atrophies.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The fetal ligament attached to the inferior end of the epididymis and testis and, at its other end, to the bottom of the scrotum; it is present during, and is thought to guide, the descent of the testis into the scrotum and then atrophies.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002813,,,,,,,BrendaTissueOBO,Hunter's gubernaculum,BTO:0002813,,,,,,,,,,,,,,,,,,,gubernaculum testis,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300136,"[""CDK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300111,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300136,,,,,,,,,,,,,,,,,,,,,,,,,,,,CDK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005491,"[""MO-91 cell""]",,Acute myelogenous leukemia-derived cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0001883|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Acute myelogenous leukemia-derived cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005491,XPMUser,2013-09-11T09:00:47Z,,,,,BrendaTissueOBO,MO91 cell|M091 cell|M0-91 cell,BTO:0005491,,,,,,,,,,,,,,,,,,,MO-91 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100489,"[""Serine/threonine-protein kinase 17a""]",,"A serine/threonine-protein kinase 17A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UEE5] |serine/threonine-protein kinase 17a (DRAK1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300146,,,,,,,,"A serine/threonine-protein kinase 17A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UEE5] |serine/threonine-protein kinase 17a (DRAK1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100489,,,,https://pharos.nih.gov/idg/targets/Q9UEE5,,,,,,,,,,,,,STK17A,DRAK1,,Q9UEE5,,,,,,,,Serine/threonine-protein kinase 17a,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100015,"[""H252 in ABL1(Q252H)-phosphorylated""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100015,,,,,,,,,,,,,,,,,,,,,,,,,,,,H252 in ABL1(Q252H)-phosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100115,"[""Dual specificity tyrosine-phosphorylation-regulated kinase 2""]",,"A dual specificity tyrosine-phosphorylation-regulated kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92630] |dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300267,,,,,,,,"A dual specificity tyrosine-phosphorylation-regulated kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92630] |dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100115,,,,https://pharos.nih.gov/idg/targets/Q92630,,,,,,,,,,,,,DYRK2,,,Q92630,,,,,,,,Dual specificity tyrosine-phosphorylation-regulated kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000067,"[""kidney cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000067,,,,,,,BrendaTissueOBO,renal cell line,BTO:0000067,,,,,,,,,,,,,,,,,,,kidney cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000266,"[""cob""]",,The central axis/core of the ear (distal end of the lateral branch/ear shoot) upon which the kernels (caryopses) are borne. The cob is similar to the central spike of the tassel (male inflorescence) in that it produces multiple rows of paired spikelets (polystichous phyllotaxy).,false,,,http://purl.obolibrary.org/obo/BTO_0001278|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The central axis/core of the ear (distal end of the lateral branch/ear shoot) upon which the kernels (caryopses) are borne. The cob is similar to the central spike of the tassel (male inflorescence) in that it produces multiple rows of paired spikelets (polystichous phyllotaxy).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000266,,,,,,,BrendaTissueOBO,corn cob|maize cob|corn ear|corncob,BTO:0000266,,,,,,,,,,,,,,,,,Zea mays.,,cob,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003900,"[""MCF-10F cell""]",,Normal breast epithelial cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002768,,,,,,,,Normal breast epithelial cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003900,,,,,,,BrendaTissueOBO,MCF10F cell,BTO:0003900,,,,,,,,,,,,,,,,,,,MCF-10F cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000117,"[""MET130 in BIKE""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000117,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET130 in BIKE,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200200,"[""GPR52 gene""]",,"A G-protein coupled receptor 52 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y2T5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400053,,,,,,,,"A G-protein coupled receptor 52 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y2T5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200200,,,,,,,,,,,,,,,,9293,GPR52,,,,,,,,,,,GPR52 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_34144,"[""12(R)-HETE""]","
12(R)-hydroxy-5,8,14-cis-10-trans-eicosatetraenoic acid
|12R-HETE|ZNHVWPKMFKADKW-ZYBDYUKJSA-N|CCCCC\C=C/C[C@@H](O)\C=C\C=C/C\C=C/CCCC(O)=O|
12(R)-hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic acid
|
InChI=1S/C20H32O3/c1-2-3-4-5-10-13-16-19(21)17-14-11-8-6-7-9-12-15-18-20(22)23/h7-11,13-14,17,19,21H,2-6,12,15-16,18H2,1H3,(H,22,23)/b9-7-,11-8-,13-10-,17-14+/t19-/m1/s1
|12(R)-hydroxyeicosatetraenoic acid|
(5Z,8Z,10E,12R,14Z)-12-hydroxy-5,8,10,14-eicosatetraenoic acid
|
(5Z,8Z,10E,14Z)-(12R)-12-Hydroxyeicosa-5,8,10,14-tetraenoic acid
|
(5Z,8Z,10E,14Z)-(12R)-12-Hydroxyicosa-5,8,10,14-tetraenoic acid
|C20H32O3|
(5Z,8Z,10E,12R,14Z)-12-hydroxyeicosa-5,8,10,14-tetraenoic acid
","
A HETE having a (12R)-hydroxy group and (5Z)-, (8Z)-, (10E)- and (14Z)-double bonds.
",false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,Reaxys:4234647|Reaxys:82337-46-0|LIPID MAPS:LMFA03060008|CiteXplore:2495992|KNApSAcK:C00000424|CiteXplore:3026490|CiteXplore:2517876|KEGG COMPOUND:C14822|CiteXplore:9044430,"
A HETE having a (12R)-hydroxy group and (5Z)-, (8Z)-, (10E)- and (14Z)-double bonds.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,"12(R)-HETE|
(5Z,8Z,10E,12R,14Z)-12-hydroxyicosa-5,8,10,14-tetraenoic acid
",,chebi_ontology,"
12(R)-hydroxy-5,8,14-cis-10-trans-eicosatetraenoic acid
|12R-HETE|ZNHVWPKMFKADKW-ZYBDYUKJSA-N|CCCCC\C=C/C[C@@H](O)\C=C\C=C/C\C=C/CCCC(O)=O|
12(R)-hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic acid
|
InChI=1S/C20H32O3/c1-2-3-4-5-10-13-16-19(21)17-14-11-8-6-7-9-12-15-18-20(22)23/h7-11,13-14,17,19,21H,2-6,12,15-16,18H2,1H3,(H,22,23)/b9-7-,11-8-,13-10-,17-14+/t19-/m1/s1
|12(R)-hydroxyeicosatetraenoic acid|
(5Z,8Z,10E,12R,14Z)-12-hydroxy-5,8,10,14-eicosatetraenoic acid
|
(5Z,8Z,10E,14Z)-(12R)-12-Hydroxyeicosa-5,8,10,14-tetraenoic acid
|
(5Z,8Z,10E,14Z)-(12R)-12-Hydroxyicosa-5,8,10,14-tetraenoic acid
|C20H32O3|
(5Z,8Z,10E,12R,14Z)-12-hydroxyeicosa-5,8,10,14-tetraenoic acid
",,,CHEBI:34144,,,,,,,,,,,,,,,,,,,,,,,CHEBI:34144,,,,,12(R)-HETE|12R-HETE,,CHEBI:34144,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100297,"[""Mitogen-activated protein kinase kinase kinase kinase 5""]",,"A mitogen-activated protein kinase kinase kinase kinase 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y4K4] |mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300287,,,,,,,,"A mitogen-activated protein kinase kinase kinase kinase 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y4K4] |mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100297,,,,https://pharos.nih.gov/idg/targets/Q9Y4K4,,,,,,,,,,,,,MAP4K5,,,Q9Y4K4,,,,,,,,Mitogen-activated protein kinase kinase kinase kinase 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002057,"[""lung adenocarcinoma cell""]",,"A type of bronchogenic carcinoma made up of cuboidal or columnar cells in a discrete mass, usually at the periphery of the lungs. Most such tumors form glandular structures containing mucin, although a minority are solid and without mucin. Growth is slow, but there may be early invasion of blood and lymph vessels, giving rise to metastases while the primary lesion is still asymptomatic.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000176|http://purl.obolibrary.org/obo/BTO_0002058,,,,,,,,"A type of bronchogenic carcinoma made up of cuboidal or columnar cells in a discrete mass, usually at the periphery of the lungs. Most such tumors form glandular structures containing mucin, although a minority are solid and without mucin. Growth is slow, but there may be early invasion of blood and lymph vessels, giving rise to metastases while the primary lesion is still asymptomatic.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002057,,,,,,,BrendaTissueOBO,pulmonary adenocarcinoma cell,BTO:0002057,,,,,,,,,,,,,,,,,,,lung adenocarcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80240,"[""Endothelin-1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG COMPOUND:C16010|KEGG COMPOUND:123626-67-5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80240,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80240,,,,,Endothelin-1,,CHEBI:80240,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391009,"[""PI3/PI4 kinase family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300323,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391009,,,,,,,,,,,,,,,,,,,,,,,,,,,,PI3/PI4 kinase family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6000,"[""congestive heart failure""]",,A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body.,false,,,http://purl.obolibrary.org/obo/DOID_114,,,,,,,,A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6000,,,DOID:395,UMLS_CUI:C0018801|ICD9CM:428|SNOMEDCT_US_2016_03_01:42343007|SNOMEDCT_US_2016_03_01:195117009|SNOMEDCT_US_2016_03_01:266308000|ICD10CM:I50|NCI:C3080|SNOMEDCT_US_2016_03_01:155375008|SNOMEDCT_US_2016_03_01:84114007|ICD9CM:428.0|SNOMEDCT_US_2016_03_01:195108009|UMLS_CUI:C0018802|SNOMEDCT_US_2016_03_01:155377000|ICD10CM:I50.9|SNOMEDCT_US_2016_03_01:155374007|MESH:D006333|ICD9CM:428.9|SNOMEDCT_US_2016_03_01:266248006|NCI:C50577,Congestive heart disease|Weak heart|Cardiac Failure Congestive|CHF,,disease_ontology,,DOID:6000,,,,,,,,,,,,,,,,,,,congestive heart failure,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100483,"[""Sphingosine kinase 2""]",,"A sphingosine kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NRA0] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300323,,,,,,,,"A sphingosine kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NRA0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100483,,,,https://pharos.nih.gov/idg/targets/Q9NRA0,,,,,,,,,,,,,SPHK2,,,Q9NRA0,,,,,,,,Sphingosine kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200206,"[""KCNH2 gene""]",,"This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400554,,,,,,,,"This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200206,,,,,,,,,,,,,,,,3757,KCNH2,ERG|ERG1|HERG,,,,,,,,,,KCNH2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100260,"[""Kinase suppressor of ras 1""]",,"A kinase suppressor of Ras 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IVT5] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300126,,,,,,,,"A kinase suppressor of Ras 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IVT5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100260,,,,https://pharos.nih.gov/idg/targets/Q8IVT5,,,,,,,,,,,,,KSR1,KSR,,Q8IVT5,,,,,,,,Kinase suppressor of ras 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100705,"[""Olfactory receptor 8K3""]",,"An olfactory receptor 8K3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH51] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 8K3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH51] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100705,,,,https://pharos.nih.gov/idg/targets/Q8NH51,,,,,,,,,,,,,OR8K3,,,Q8NH51,,,,,,,,Olfactory receptor 8K3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200238,"[""KCNS2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400567,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200238,,,,,,,,,,,,,,,,3788,KCNS2,KIAA1144,,,,,,,,,,KCNS2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100055,"[""Cyclin-dependent kinase 11b""]",,"A cyclin-dependent kinase 11B that is encoded in the genome of human. [PRO:DNx, UniProtKB:P21127] |cyclin-dependent kinase 11b (CDC2L1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300254,,,,,,,,"A cyclin-dependent kinase 11B that is encoded in the genome of human. [PRO:DNx, UniProtKB:P21127] |cyclin-dependent kinase 11b (CDC2L1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100055,,,,https://pharos.nih.gov/idg/targets/P21127,,,,,,,,,,,,,CDK11B,CDC2L1|CDK11|PITSLREA|PK58,,P21127,,,,,,,,Cyclin-dependent kinase 11b,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13014,"[""shipyard eye""]",,,false,,,http://purl.obolibrary.org/obo/DOID_9368,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13014,,,,NCI:C34590|ICD10CM:B30.0|UMLS_CUI:C0014493|SNOMEDCT_US_2016_03_01:60548004|ICD9CM:077.1,EKC|Epidemic keratoconjunctivitis,,disease_ontology,,DOID:13014,,,,,,,,,,,,,,,,,,,shipyard eye,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003914,"[""interstitial cell of Cajal""]",,"Pleomorphic cells having an oval nucleus and long, branching cytoplasmic processes that interlace with processes of adjacent cells, interspersed between the circular and longitudinal muscle layers of the gastrointestinal tract and in the smooth muscle of the esophagus; they are thought to act as pacemakers.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0004238,,,,,,,,"Pleomorphic cells having an oval nucleus and long, branching cytoplasmic processes that interlace with processes of adjacent cells, interspersed between the circular and longitudinal muscle layers of the gastrointestinal tract and in the smooth muscle of the esophagus; they are thought to act as pacemakers.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003914,,,,,,,BrendaTissueOBO,ICC cell,BTO:0003914,,,,,,,,,,,,,,,,,,,interstitial cell of Cajal,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400498,"[""Alpha-1/CHRNA1 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400498,,,,,,,,,,,,,,,,,,,,,,,,,,,,Alpha-1/CHRNA1 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200588,"[""HK2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200588,,,,,,,,,,,,,,,,,,,,,,,,,,,,HK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100431,"[""Serine/threonine-protein kinase plk2""]",,"serine/threonine-protein kinase plk2 (PLK2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase PLK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYY3] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300211,,,,,,,,"serine/threonine-protein kinase plk2 (PLK2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase PLK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYY3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100431,,,,https://pharos.nih.gov/idg/targets/Q9NYY3,,,,,,,,,,,,,PLK2,SNK,,Q9NYY3,,,,,,,,Serine/threonine-protein kinase plk2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100748,"[""Prostacyclin receptor""]",,"A prostacyclin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43119] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A prostacyclin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43119] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100748,,,,https://pharos.nih.gov/idg/targets/P43119,,,,,,,,,,,,,PTGIR,PRIPR,,P43119,,,,,,,,Prostacyclin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200264,"[""P2RX1 gene""]",,"The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_01400364,,,,,,,,"The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200264,,,,,,,,,,,,,,,,5023,P2RX1,P2X1,,,,,,,,,,P2RX1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200556,"[""ULK2 gene""]",,"This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400228,,,,,,,,"This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200556,,,,,,,,,,,,,,,,9706,ULK2,KIAA0623,,,,,,,,,,ULK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200276,"[""MAP3K10 gene""]",,"The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400284,,,,,,,,"The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200276,,,,,,,,,,,,,,,,4294,MAP3K10,MLK2|MST,,,,,,,,,,MAP3K10 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004561,"[""thymic stromal cell""]",,Cells in the thymus can be divided into thymic stromal cells and cells of hematopoietic origin.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Cells in the thymus can be divided into thymic stromal cells and cells of hematopoietic origin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004561,mgr,2010-02-16T08:07:21Z,,,,,BrendaTissueOBO,,BTO:0004561,,,,,,,,,,,,,,,,,,,thymic stromal cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200220,"[""GRM3 gene""]",,"A metabotropic glutamate receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14832] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400059,,,,,,,,"A metabotropic glutamate receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14832] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200220,,,,,,,,,,,,,,,,2913,GRM3,GPRC1C|MGLUR3,,,,,,,,,,GRM3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000228,"[""KPCE kinase domain""]",,"Protein kinase C, epsilon; MGC125656; MGC125657; nPKC-epsilon; PKCE; PRKCE",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Protein kinase C, epsilon; MGC125656; MGC125657; nPKC-epsilon; PKCE; PRKCE",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000228,,,,,,,,,,,,,,,,,,,200355,,,,,,,,,KPCE kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200122,"[""GABRR1 gene""]",,"GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400521,,,,,,,,"GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200122,,,,,,,,,,,,,,,,2569,GABRR1,,,,,,,,,,,GABRR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000415,"[""SRMS kinase domain""]",,Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites; C20orf148; dJ697K14.1; SRM; SRMS,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites; C20orf148; dJ697K14.1; SRM; SRMS,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000415,,,,,,,,,,,,,,,,,,,200416,,,,,,,,,SRMS kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200118,"[""EIF2AK1 gene""]",,"The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400151,,,,,,,,"The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200118,,,,,,,,,,,,,,,,27102,EIF2AK1,HRI|KIAA1369,,,,,,,,,,EIF2AK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003736,"[""thyroid epithelial cell""]",,An epithelial cell lining the thyroid follicle.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000414,,,,,,,,An epithelial cell lining the thyroid follicle.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003736,,,,,,,BrendaTissueOBO,thyroid follicular cell|thyrocyte,BTO:0003736,,,,,,,,,,,,,,,,,,,thyroid epithelial cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100054,"[""C-C chemokine receptor type 2""]",,"A C-C chemokine receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41597] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300095,,,,,,,,"A C-C chemokine receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41597] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100054,,,,https://pharos.nih.gov/idg/targets/P41597,,,,,,,,,,,,,CCR2,CMKBR2,,P41597,,,,,,,,C-C chemokine receptor type 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000887,"[""muscle""]",,A body tissue consisting of long cells that contract when stimulated and produce motion.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001485|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,,A body tissue consisting of long cells that contract when stimulated and produce motion.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000887,,,,,,,BrendaTissueOBO,,BTO:0000887,,,,,,,,,,,,,,,,,,,muscle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000916,"[""NC37 cell""]",,Human lymphoblastoid cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000773,,,,,,,,Human lymphoblastoid cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000916,,,,,,,BrendaTissueOBO,,BTO:0000916,,,,,,,,,,,,,,,,,,,NC37 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001225,"[""MKN-45 cell""]",,"Human gastric adenocarcinoma, established from the poorly differentiated adenocarcinoma of the stomach (medullary type) of a 62-year-old woman.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002380,,,,,,,,"Human gastric adenocarcinoma, established from the poorly differentiated adenocarcinoma of the stomach (medullary type) of a 62-year-old woman.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001225,,,,,,,BrendaTissueOBO,MKN45 cell,BTO:0001225,,,,,,,,,,,,,,,,,,,MKN-45 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200299,"[""SCN8A gene""]",,"This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with mental retardation, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400473,,,,,,,,"This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with mental retardation, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200299,,,,,,,,,,,,,,,,6334,SCN8A,MED,,,,,,,,,,SCN8A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300133,"[""TEC family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300133,,,,,,,,,,,,,,,,,,,,,,,,,,,,TEC family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001658,"[""aerial part""]",,Existing or growing in the air rather than in the ground or in water.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Existing or growing in the air rather than in the ground or in water.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001658,,,,,,,BrendaTissueOBO,aerial tissue|aerial body,BTO:0001658,,,,,,,,,,,,,,,,,,,aerial part,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100107,"[""Diacylglycerol kinase alpha""]",,"A diacylglycerol kinase alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23743] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391025,,,,,,,,"A diacylglycerol kinase alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23743] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100107,,,,https://pharos.nih.gov/idg/targets/P23743,,,,,,,,,,,,,DGKA,DAGK|DAGK1,,P23743,,,,,,,,Diacylglycerol kinase alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100054,"[""Calcium homeostasis modulator protein 3""]",,"A calcium homeostasis modulator protein 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86XJ0] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300335,,,,,,,,"A calcium homeostasis modulator protein 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86XJ0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100054,,,,https://pharos.nih.gov/idg/targets/Q86XJ0,,,,,,,,,,,,,CALHM3,FAM26A,,Q86XJ0,,,,,,,,Calcium homeostasis modulator protein 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100444,"[""Olfactory receptor 56b4""]",,"An olfactory receptor 56B4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH76] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 56B4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH76] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100444,,,,https://pharos.nih.gov/idg/targets/Q8NH76,,,,,,,,,,,,,OR56B4,,,Q8NH76,,,,,,,,Olfactory receptor 56b4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001864,"[""AsPC-1 cell""]",,"Human caucasian pancreas adenocarcinoma cell line, established from a 62 years old caucasian female.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001521,,,,,,,,"Human caucasian pancreas adenocarcinoma cell line, established from a 62 years old caucasian female.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001864,,,,,,,BrendaTissueOBO,AsPC1 cell|As-PC1 cell,BTO:0001864,,,,,,,,,,,,,,,,,,,AsPC-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000302,"[""MYLK kinase domain""]",,Myosin light chain kinase; DKFZp686I10125; FLJ12216; KRP; MLCK; MLCK1; MLCK108; MLCK210; MSTP083; MYLK; MYLK1; smMLCK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Myosin light chain kinase; DKFZp686I10125; FLJ12216; KRP; MLCK; MLCK1; MLCK108; MLCK210; MSTP083; MYLK; MYLK1; smMLCK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000302,,,,,,,,,,,,,,,,,,,200279,,,,,,,,,MYLK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003835,"[""cerebellar nucleus""]",,"Four accumulations of gray substance embedded in the white substance of the cerebellum, comprising the nucleus dentatus, nucleus emboliformis, nucleus globosus, and nucleus fastigii.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Four accumulations of gray substance embedded in the white substance of the cerebellum, comprising the nucleus dentatus, nucleus emboliformis, nucleus globosus, and nucleus fastigii.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003835,,,,,,,BrendaTissueOBO,,BTO:0003835,,,,,,,,,,,,,,,,,,,cerebellar nucleus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005034,"[""DT-40 3KO cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005034,XPMUser,2011-03-05T10:43:04Z,,,,,BrendaTissueOBO,,BTO:0005034,,,,,,,,,,,,,,,,,,,DT-40 3KO cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200270,"[""LMTK2 gene""]",,"The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400183,,,,,,,,"The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200270,,,,,,,,,,,,,,,,22853,LMTK2,AATYK2|BREK|KIAA1079,,,,,,,,,,LMTK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400412,"[""GRIA3 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400412,,,,,,,,,,,,,,,,,,,,,,,,,,,,GRIA3 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1856,"[""cherubism""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1856,,,,SNOMEDCT_US_2016_03_01:53432004|UMLS_CUI:C0008029|ICD10CM:M27.8|NCI:C84630|SNOMEDCT_US_2016_03_01:76098004|OMIM:118400|MESH:D002636,,,disease_ontology,,DOID:1856,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,cherubism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400111,"[""CMGC group gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400102,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400111,,,,,,,,,,,,,,,,,,,,,,,,,,,,CMGC group gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100365,"[""Serine/threonine-protein kinase nim1""]",,serine/threonine-protein kinase nim1 (NIM1)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase NIM1 that is encoded in the genome of human. ,false,,,http://www.drugtargetontology.org/dto/DTO_03300299,,,,,,,,serine/threonine-protein kinase nim1 (NIM1)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase NIM1 that is encoded in the genome of human. ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100365,,,,https://pharos.nih.gov/idg/targets/Q8IY84,,,,,,,,,,,,,NIM1K,NIM1,,Q8IY84,,,,,,,,Serine/threonine-protein kinase nim1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14227,"[""azoospermia""]",,A male infertility disease characterized by the absence of any measurable level of sperm in semen.,false,,,http://purl.obolibrary.org/obo/DOID_12336,,,,,,,,A male infertility disease characterized by the absence of any measurable level of sperm in semen.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14227,,,,ICD10CM:N46.0|OMIM:243060|OMIM:612997|OMIM:108420|MESH:D053713|OMIM:606766|ICD10CM:N46.01|OMIM:613958|OMIM:415000|SNOMEDCT_US_2016_03_01:155925000|OMIM:613957|OMIM:615081|OMIM:309120|EFO:0000279|OMIM:270960|OMIM:102530|SNOMEDCT_US_2016_03_01:167781002|SNOMEDCT_US_2016_03_01:145008007|SNOMEDCT_US_2016_03_01:48188009|OMIM:258150|SNOMEDCT_US_2016_03_01:425558002|OMIM:615842|OMIM:614822|ORDO:217034|ICD9CM:606.0|NCI:C80076|OMIM:615841|OMIM:615413|SNOMEDCT_US_2016_03_01:198010009|UMLS_CUI:C0004509,spermatogenic failure,,disease_ontology,,DOID:14227,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,Xref MGI.,,azoospermia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14228,"[""oligospermia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_12336,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14228,,,,ICD9CM:606.1|UMLS_CUI:C0028960|NCI:C34860|ICD10CM:N46.11|ICD10CM:N46.1|MESH:D009845,,,disease_ontology,,DOID:14228,,,,,,,,,,,,,,,,,,,oligospermia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14221,"[""metabolic syndrome X""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0060611,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14221,,,,ICD9CM:277.7|MESH:D024821|SNOMEDCT_US_2016_03_01:237602007|OMIM:605552|NCI:C84442|UMLS_CUI:C0524620|SNOMEDCT_US_2016_03_01:190394009|ICD10CM:E88.81|EFO:0000195,dysmetabolic syndrome X|abdominal obesity-metabolic syndrome 1,,disease_ontology,,DOID:14221,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,metabolic syndrome X,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002146,"[""CAL-62 cell""]",,"Human thyroid anaplastic carcinoma cell line, established from the thyroid gland (right lobe) of a 70-year-old woman with thyroid anaplastic carcinoma in 1988; described as being tumorigenic in heterotransplanted nude mice.",false,,,http://purl.obolibrary.org/obo/BTO_0003209|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Human thyroid anaplastic carcinoma cell line, established from the thyroid gland (right lobe) of a 70-year-old woman with thyroid anaplastic carcinoma in 1988; described as being tumorigenic in heterotransplanted nude mice.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002146,mgr,2010-09-28T04:03:16Z,,,,,BrendaTissueOBO,,BTO:0002146,,,,,,,,,,,,,,,,,,,CAL-62 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13316,"[""exocrine pancreatic insufficiency""]",,,false,,,http://purl.obolibrary.org/obo/DOID_26,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13316,,,,UMLS_CUI:C0267963|NCI:C84316|MESH:D010188|SNOMEDCT_US_2016_03_01:47367009,Exocrine pancreatic insufficiency (disorder),,disease_ontology,,DOID:13316,,,,,,,,,,,,,,,,,,,exocrine pancreatic insufficiency,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13317,"[""hyperinsulinemic hypoglycemia""]",,A carbohydrate metabolic disorder that involves low blood glucose resulting from an excess of insulin.,false,,,http://purl.obolibrary.org/obo/DOID_2978,,,,,,,,A carbohydrate metabolic disorder that involves low blood glucose resulting from an excess of insulin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13317,,,DOID:9996,MESH:D046768|ICD10CM:E16.9|SNOMEDCT_US_2016_03_01:190450004|SNOMEDCT_US_2016_03_01:237649006|OMIM:602485|NCI:C4375|OMIM:601820|OMIM:610021|UMLS_CUI:C0027773|SNOMEDCT_US_2016_03_01:360337007|OMIM:609968|OMIM:609975|OMIM:606762|OMIM:256450|SNOMEDCT_US_2016_03_01:42681006|SNOMEDCT_US_2016_03_01:66149005,persistent hyperinsulinemia hypoglycemia of infancy|nesidioblastosis|Islet cell hyperplasia,,disease_ontology,,DOID:13317,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,hyperinsulinemic hypoglycemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004717,"[""large granular lymphocyte""]",,A type of white blood cell that contains granules with enzymes that can kill tumor cells or microbial cells.,false,,,http://purl.obolibrary.org/obo/BTO_0000775|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A type of white blood cell that contains granules with enzymes that can kill tumor cells or microbial cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004717,mgr,2010-05-18T11:40:56Z,,,,,BrendaTissueOBO,,BTO:0004717,,,,,,,,,,,,,,,,,,,large granular lymphocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80302,"[""Pituitary adenylate cyclase-activating peptide-38""]",PACAP-38,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16088,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,PACAP-38,,,CHEBI:80302,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80302,,,,,Pituitary adenylate cyclase-activating peptide-38,,CHEBI:80302,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100111,"[""Frizzled-9""]",,"A frizzled-9 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O00144] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300043,,,,,,,,"A frizzled-9 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O00144] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100111,,,,https://pharos.nih.gov/idg/targets/O00144,,,,,,,,,,,,,FZD9,FZD3,,O00144,,,,,,,,Frizzled-9,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2772,"[""irritant dermatitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2773,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2772,,,,ICD10CM:L24|MESH:D017453|SNOMEDCT_US_2016_03_01:110979008|NCI:C27151|SNOMEDCT_US_2016_03_01:200850007|UMLS_CUI:C0162823|ICD10CM:L24.9,Irritant Contact Dermatitis|Irritant contact dermatitis|primary irritant dermatitis (disorder),,disease_ontology,,DOID:2772,,,,,,,,,,,,,,,,,,,irritant dermatitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_16828,"[""L-tryptophan""]","W|N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O|(S)-tryptophan|QIVBCDIJIAJPQS-VIFPVBQESA-N|tryptophan|204.22526|L-beta-3-indolylalanine|(S)-alpha-Amino-beta-(3-indolyl)-propionic acid|(S)-alpha-amino-1H-indole-3-propanoic acid|(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid|InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1|C11H12N2O2|TRYPTOPHAN|Trp|L-(-)-tryptophan|0|204.090|Tryptophan",The L-enantiomer of tryptophan.,false,,,http://purl.obolibrary.org/obo/CHEBI_33709,,,,,,,Wikipedia:Tryptophan|PMID:17127472|Gmelin:51434|PMID:17177562|KEGG:D00020|Reaxys:86197|PMID:17690425|PMID:22071091|HMDB:HMDB00929|PMID:22415306|PMID:17826001|YMDB:YMDB00126|PMID:11750787|PMID:18949702|PMID:22415302|PMID:11888576|PMID:22402312|CAS:73-22-3|PMID:19896323|PMID:17430113|PMID:22299628|Beilstein:86197|KEGG:C00078|PMID:21856896|PMID:22162421|PMID:12830226|PMID:11395471|PDBeChem:TRP|PMID:2917974|PMID:15206750|ECMDB:ECMDB00929|PMID:18234569|PMID:18419734|PMID:22386992|MetaCyc:TRP|PMID:16934873|KNApSAcK:C00001396|PMID:12871129|PMID:16740930|Drug_Central:2780|DrugBank:DB00150|PMID:17585690|PMID:12766158,The L-enantiomer of tryptophan.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:13178|CHEBI:184633|CHEBI:46225|CHEBI:45988|CHEBI:46086|CHEBI:46125|CHEBI:6310|CHEBI:21407,,L-tryptophan|L-Tryptophan,,chebi_ontology,"W|N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O|(S)-tryptophan|QIVBCDIJIAJPQS-VIFPVBQESA-N|tryptophan|204.22526|L-beta-3-indolylalanine|(S)-alpha-Amino-beta-(3-indolyl)-propionic acid|(S)-alpha-amino-1H-indole-3-propanoic acid|(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid|InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1|C11H12N2O2|TRYPTOPHAN|Trp|L-(-)-tryptophan|0|204.090|Tryptophan",,,CHEBI:16828,,,,,,,,,,,,,,,,,,,,,,,CHEBI:16828,,,,,L-tryptophan,,CHEBI:16828,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200647,"[""OR5T3 gene""]",,"An olfactory receptor 5T3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5T3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200647,,,,,,,,,,,,,,,,390154,OR5T3,,,,,,,,,,,OR5T3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000297,"[""carcinoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001120,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000297,,,,,,,BrendaTissueOBO,,BTO:0000297,,,,,,,,,,,,,,,,,,,carcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000420,"[""STK33 kinase domain""]",,Serine/threonine kinase 33,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine kinase 33,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000420,,,,,,,,,,,,,,,,,,,200421,,,,,,,,,STK33 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001124,"[""promastigote""]",,"Any of the bodies representing the morphological leptomonad stage in the life cycle of certain trypanosomatid protozoa resembling the typical adult form of members of the genus Leptomonas, in which the elongate or pear-shaped cell has a central nucleus and at the anterior end a kinetoplast and a basal body from which arises a single long, slender flagellum.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000092,,,,,,,,"Any of the bodies representing the morphological leptomonad stage in the life cycle of certain trypanosomatid protozoa resembling the typical adult form of members of the genus Leptomonas, in which the elongate or pear-shaped cell has a central nucleus and at the anterior end a kinetoplast and a basal body from which arises a single long, slender flagellum.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001124,,,,,,,BrendaTissueOBO,,BTO:0001124,,,,,,,,,,,,,,,,,,,promastigote,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200275,"[""LYN gene""]",,"This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400132,,,,,,,,"This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200275,,,,,,,,,,,,,,,,4067,LYN,JTK8,,,,,,,,,,LYN gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300197,"[""NEK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300197,,,,,,,,,,,,,,,,,,,,,,,,,,,,NEK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100114,"[""Dual specificity tyrosine-phosphorylation-regulated kinase 1b""]",,"A dual specificity tyrosine-phosphorylation-regulated kinase 1B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y463] |dual specificity tyrosine-phosphorylation-regulated kinase 1b (DYRK1B)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300266,,,,,,,,"A dual specificity tyrosine-phosphorylation-regulated kinase 1B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y463] |dual specificity tyrosine-phosphorylation-regulated kinase 1b (DYRK1B)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100114,,,,https://pharos.nih.gov/idg/targets/Q9Y463,,,,,,,,,,,,,DYRK1B,MIRK,,Q9Y463,,,,,,,,Dual specificity tyrosine-phosphorylation-regulated kinase 1b,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100599,"[""Olfactory receptor 4M1""]",,"An olfactory receptor 4M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100599,,,,https://pharos.nih.gov/idg/targets/Q8NGD0,,,,,,,,,,,,,OR4M1,,,Q8NGD0,,,,,,,,Olfactory receptor 4M1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100742,"[""Prostaglandin D2 receptor""]",,"A prostaglandin D2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13258] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A prostaglandin D2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13258] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100742,,,,https://pharos.nih.gov/idg/targets/Q13258,,,,,,,,,,,,,PTGDR,,,Q13258,,,,,,,,Prostaglandin D2 receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002278,"[""macrophage cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001035,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002278,,,,,,,BrendaTissueOBO,,BTO:0002278,,,,,,,,,,,,,,,,,,,macrophage cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100167,"[""Retinal guanylyl cyclase 1""]",,"A retinal guanylyl cyclase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02846] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300125,,,,,,,,"A retinal guanylyl cyclase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02846] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100167,,,,https://pharos.nih.gov/idg/targets/Q02846,,,,,,,,,,,,,GUCY2D,CORD6|GUC1A4|GUC2D|RETGC|RETGC1,,Q02846,,,,,,,,Retinal guanylyl cyclase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80257,"[""Neuropeptide W-23""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16033,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80257,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80257,,,,,Neuropeptide W-23,,CHEBI:80257,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200069,"[""CMKLR1 gene""]",,"A chemokine receptor-like protein CMKLR1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99788] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400034,,,,,,,,"A chemokine receptor-like protein CMKLR1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99788] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200069,,,,,,,,,,,,,,,,1240,CMKLR1,CHEMR23|DEZ,,,,,,,,,,CMKLR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400153,"[""EPH family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400153,,,,,,,,,,,,,,,,,,,,,,,,,,,,EPH family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10283,"[""prostate cancer""]",,A male reproductive organ cancer that is located_in the prostate.,false,,,http://purl.obolibrary.org/obo/DOID_3856|http://purl.obolibrary.org/obo/DOID_47,,,,,,,,A male reproductive organ cancer that is located_in the prostate.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10283,,,DOID:514,MESH:D011471|OMIM:609299|OMIM:611928|SNOMEDCT_US_2016_03_01:93974005|UMLS_CUI:C0376358|SNOMEDCT_US_2016_03_01:126906006|NCI:C7378|OMIM:611959|OMIM:300147|NCI:C3343|SNOMEDCT_US_2016_03_01:363448003|OMIM:608658|OMIM:300704|ICD9CM:185|ORDO:1331|OMIM:601518|OMIM:610321|OMIM:611868|OMIM:176807|ICD10CM:C61|OMIM:610997|OMIM:611958|OMIM:608656|OMIM:611100|OMIM:609558|OMIM:602759|KEGG:05215|OMIM:611955|SNOMEDCT_US_2016_03_01:399068003|UMLS_CUI:C0033578,"hereditary prostate cancer|malignant tumor of the prostate|prostate neoplasm|prostatic neoplasm|tumor of the prostate|NGP - new growth of prostate|prostate cancer, familial|prostatic cancer",,disease_ontology,,DOID:10283,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,prostate cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10286,"[""prostate carcinoma""]",,A prostate cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.,false,,,http://purl.obolibrary.org/obo/DOID_305|http://purl.obolibrary.org/obo/DOID_10283,,,,,,,,A prostate cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10286,,,,SNOMEDCT_US_2016_03_01:254900004|EFO:0001663|UMLS_CUI:C0600139|SNOMEDCT_US_2016_03_01:363448003|NCI:C4863|SNOMEDCT_US_2016_03_01:154531004|KEGG:05215,cancer of prostate|carcinoma OF PROSTATE|carcinoma of prostate|carcinoma of prostate (disorder),,disease_ontology,,DOID:10286,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,prostate carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000378,"[""THR681 in PGFRB""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000378,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR681 in PGFRB,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200471,"[""OPRL1 gene""]",,"A nociceptin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41146] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A nociceptin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41146] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200471,,,,,,,,,,,,,,,,4987,OPRL1,OOR|ORL1,,,,,,,,,,OPRL1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002207,"[""NCI-H460 cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002205,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002207,,,,,,,BrendaTissueOBO,H-460 cell|H460 cell,BTO:0002207,,,,,,,,,,,,,,,,,,,NCI-H460 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000407,"[""THR798 in ERBB2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000407,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR798 in ERBB2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000411,"[""THR95 in RIPK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000411,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR95 in RIPK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3939,"[""lipomatous cancer""]",,,false,,,http://purl.obolibrary.org/obo/DOID_201,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3939,,,,NCI:C4501|SNOMEDCT_US_2016_03_01:254828009|UMLS_CUI:C0346117,malignant lipomatous tumor (disorder)|malignant tumor of Adipose tissue,,disease_ontology,,DOID:3939,,,,,,,,,,,,,,,,,,,lipomatous cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300047,"[""Glucagon receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300003,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300047,,,,,,,,,,,,,,,,,,,,,,,,,,,,Glucagon receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300336,"[""Calcium channel auxiliary subunit 1-8 (cca) family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300336,,,,,,,,,,,,,,,,,,,,,,,,,,,,Calcium channel auxiliary subunit 1-8 (cca) family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300391,"[""CACNG subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300337,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300391,,,,,,,,,,,,,,,,,,,,,,,,,,,,CACNG subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_28790,"[""serotonin""]","serotonine|thrombotonin|5-hydroxy-tryptamine|3-(2-azanylethyl)-1H-indol-5-ol|Enteramine|3-(b-Aminoethyl)-5-hydroxyindole|3-(2-Aminoethyl)-1H-indol-5-ol|Enteramin|5-Hydroxy-3-(b-aminoethyl)indole|5-HTA|thrombocytin|C10H12N2O|5-Hydroxyltryptamine|Antemovis|DS substance|5-Hydroxytriptamine|NCCc1c[nH]c2ccc(O)cc12|5-HT|5-Hydroxytryptamine|QZAYGJVTTNCVMB-UHFFFAOYSA-N|Antemoqua|3-(2-Aminoethyl)indol-5-ol|
InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
|Hippophaine","
A primary amino compound that is the 5-hydroxy derivative of tryptamine.
",false,,,http://purl.obolibrary.org/obo/CHEBI_32952,,,,,,,CiteXplore:18593914|CiteXplore:2459577|CiteXplore:12912814|Beilstein:143524|CiteXplore:1691117|Reaxys:143524|CiteXplore:16515859|CiteXplore:16412483|Wikipedia:Serotonin|CiteXplore:16366421|ChemIDplus:50-67-9|CiteXplore:16289360|CiteXplore:2580417|CiteXplore:8884658|CiteXplore:9849813|CiteXplore:16939882|CiteXplore:16580588|PDBeChem:SRO|CiteXplore:22770225|HMDB:HMDB00259|KNApSAcK:C00001429|CiteXplore:12834252|CiteXplore:16047543|CiteXplore:16842443|MetaCyc:SEROTONIN|Gmelin:1861995|KEGG COMPOUND:50-67-9|CiteXplore:9931050|CiteXplore:16516555|CiteXplore:16435178|CiteXplore:24136337|CiteXplore:21939218|CiteXplore:16884454|CiteXplore:10367709|CiteXplore:16652315|KEGG COMPOUND:C00780,"
A primary amino compound that is the 5-hydroxy derivative of tryptamine.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:1420|CHEBI:26652|CHEBI:49894,,SEROTONIN|Serotonin|3-(2-aminoethyl)-1H-indol-5-ol,,chebi_ontology,"serotonine|thrombotonin|5-hydroxy-tryptamine|3-(2-azanylethyl)-1H-indol-5-ol|Enteramine|3-(b-Aminoethyl)-5-hydroxyindole|3-(2-Aminoethyl)-1H-indol-5-ol|Enteramin|5-Hydroxy-3-(b-aminoethyl)indole|5-HTA|thrombocytin|C10H12N2O|5-Hydroxyltryptamine|Antemovis|DS substance|5-Hydroxytriptamine|NCCc1c[nH]c2ccc(O)cc12|5-HT|5-Hydroxytryptamine|QZAYGJVTTNCVMB-UHFFFAOYSA-N|Antemoqua|3-(2-Aminoethyl)indol-5-ol|
InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
|Hippophaine",,,CHEBI:28790,,,,,,,,,,,,,,,,,,,,,,,CHEBI:28790,,,,,serotonin,,CHEBI:28790,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000196,"[""thyroid cancer cell""]",,Cancer cell of the thyroid gland.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Cancer cell of the thyroid gland.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000196,,,,,,,BrendaTissueOBO,"thyroid carcinoma cell|carcinoma cell, thyroid",BTO:0000196,,,,,,,,,,,,,,,,,,,thyroid cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0080015,"[""physical disorder""]",,"A disease that has_material_basis_in a genetic abnormality, error with embryonic development, infection or compromised intrauterine environment.",false,,,http://purl.obolibrary.org/obo/DOID_4,,,,,,,,"A disease that has_material_basis_in a genetic abnormality, error with embryonic development, infection or compromised intrauterine environment.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0080015,,,,,,,disease_ontology,,DOID:0080015,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,physical disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0080014,"[""chromosomal disease""]",,"A genetic disease that has_material_basis_in extra, missing, or re-arranged chromosomes.",false,,,http://purl.obolibrary.org/obo/DOID_630,,,,,,,,"A genetic disease that has_material_basis_in extra, missing, or re-arranged chromosomes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0080014,,,,,,,disease_ontology,,DOID:0080014,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,chromosomal disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0080011,"[""bone resorption disease""]",,A bone remodeling disease that results in an abnormal decrease of bone density or mass.,false,,,http://purl.obolibrary.org/obo/DOID_0080005,,,,,,,,A bone remodeling disease that results in an abnormal decrease of bone density or mass.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0080011,,,,MESH:D001862,,,disease_ontology,,DOID:0080011,,,,,,,,,,,,,,,,,,,bone resorption disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0080019,"[""metaphyseal dysplasia""]",,An osteochondrodysplasia that results_in thinning and the tendency to fracture located_in bone.,false,,,http://purl.obolibrary.org/obo/DOID_2256,,,,,,,,An osteochondrodysplasia that results_in thinning and the tendency to fracture located_in bone.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0080019,,,,OMIM:215050,Pyle's disease|Bakwin-Krida syndrome|Pyle-Cohn syndrome,,disease_ontology,,DOID:0080019,,,,,,,,,,,,,,,,,,,metaphyseal dysplasia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0080010,"[""bone structure disease""]",,A bone disease that has_material_basis_in an abnormality in the location or function of the skeletal structure.,false,,,http://purl.obolibrary.org/obo/DOID_0080001,,,,,,,,A bone disease that has_material_basis_in an abnormality in the location or function of the skeletal structure.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0080010,,,,,,,disease_ontology,,DOID:0080010,,,,,,,,,,,,,,,,,,,bone structure disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0080016,"[""spina bifida""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0080074,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0080016,,,,,,,disease_ontology,,DOID:0080016,,,,,,,,,,,,,,,,,,,spina bifida,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200096,"[""CATSPER4 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400345,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200096,,,,,,,,,,,,,,,,378807,CATSPER4,,,,,,,,,,,CATSPER4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100118,"[""Eukaryotic translation initiation factor 2-alpha kinase 1""]",,A eukaryotic translation initiation factor 2-alpha kinase 1 that is encoded in the genome of human. |eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1)  with  no mutation  in a nonphosphorylated state,false,,,http://www.drugtargetontology.org/dto/DTO_03300151,,,,,,,,A eukaryotic translation initiation factor 2-alpha kinase 1 that is encoded in the genome of human. |eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1)  with  no mutation  in a nonphosphorylated state,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100118,,,,https://pharos.nih.gov/idg/targets/Q9BQI3,,,,,,,,,,,,,EIF2AK1,HRI|KIAA1369,,Q9BQI3,,,,,,,,Eukaryotic translation initiation factor 2-alpha kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200280,"[""MAP3K14 gene""]",,"This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400185,,,,,,,,"This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200280,,,,,,,,,,,,,,,,9020,MAP3K14,NIK,,,,,,,,,,MAP3K14 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3083,"[""chronic obstructive pulmonary disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2320,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3083,,,DOID:6144|DOID:11500,SNOMEDCT_US_2016_03_01:155569000|SNOMEDCT_US_2016_03_01:195935004|SNOMEDCT_US_2016_03_01:155565006|SNOMEDCT_US_2016_03_01:155585005|SNOMEDCT_US_2016_03_01:13645005|ICD10CM:J44.9|SNOMEDCT_US_2016_03_01:413846005|SNOMEDCT_US_2016_03_01:155617000|MESH:D029424|SNOMEDCT_US_2016_03_01:196003006|UMLS_CUI:C0024117|EFO:0000341|SNOMEDCT_US_2016_03_01:195948000|NCI:C3199,chronic obstructive lung disease|chronic obstructive airway disease|COPD|COLD (chronic obstructive lung disease),,disease_ontology,,DOID:3083,,,,,,,,,,,,,,,,,,,chronic obstructive pulmonary disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100582,"[""Olfactory receptor 4D10""]",,"An olfactory receptor 4D10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4D10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100582,,,,https://pharos.nih.gov/idg/targets/Q8NGI6,,,,,,,,,,,,,OR4D10,OR4D10P,,Q8NGI6,,,,,,,,Olfactory receptor 4D10,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200187,"[""KCNB1 gene""]",,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400539,,,,,,,,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200187,,,,,,,,,,,,,,,,3745,KCNB1,,,,,,,,,,,KCNB1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9505,"[""cannabis abuse""]",,A substance abuse that involves the recurring use of cannabis despite negative consequences.,false,,,http://purl.obolibrary.org/obo/DOID_302,,,,,,,,A substance abuse that involves the recurring use of cannabis despite negative consequences.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9505,,,DOID:2525,ICD9CM:305.2|MESH:D002189|SNOMEDCT_US_2016_03_01:268769003|ICD10CM:F12|SNOMEDCT_US_2016_03_01:37344009|ICD10CM:F12.1|UMLS_CUI:C0006868|UMLS_CUI:C0024809,marijuana abuse,,disease_ontology,,DOID:9505,,,,,,,,,,,,,,,,,,,cannabis abuse,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200247,"[""LRRC52 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200247,,,,,,,,,,,,,,,,,LRRC52,,,,,,,,,,,LRRC52 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400521,"[""GABRR1 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400521,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRR1 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400513,"[""GABRB2 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400513,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRB2 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000362,"[""PKAC-beta kinase domain""]",,"Protein kinase, cAMP-dependent, catalytic, beta; DKFZp781I2452; MGC41879; MGC9320; PKAb; PKACB; PKAC-b; PKACbeta; PKAC-beta; PRKACB",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Protein kinase, cAMP-dependent, catalytic, beta; DKFZp781I2452; MGC41879; MGC9320; PKAb; PKACB; PKAC-b; PKACbeta; PKAC-beta; PRKACB",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000362,,,,,,,,,,,,,,,,,,,200345,,,,,,,,,PKAC-beta kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000604,"[""adenocarcinoma cell""]",,A cell of a cancer that begins in cells that line certain internal organs and that have glandular (secretory) properties.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000176,,,,,,,,A cell of a cancer that begins in cells that line certain internal organs and that have glandular (secretory) properties.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000604,,,,,,,BrendaTissueOBO,,BTO:0000604,,,,,,,,,,,,,,,,,,,adenocarcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_46858,"[""L-tyrosine residue""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_33700,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:46858,,,CHEBI:29975|CHEBI:46207,RESID:AA0019|PDBeChem:TYR_LL,L-tyrosine residue,,chebi_ontology,L-tyrosine|L-tyrosine acid residue|Y|L-tyrosyl|C9H9NO2|163.17330|163.063|Tyr|0,CHEBI:46858,http://purl.obolibrary.org/obo/chebi#3_STAR,,,,,,,,,,,,,,,,,,L-tyrosine residue,,,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200568,"[""OR4B1 gene""]",,"An olfactory receptor 4B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200568,,,,,,,,,,,,,,,,119765,OR4B1,,,,,,,,,,,OR4B1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200610,"[""NME2P1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200610,,,,,,,,,,,,,,,,,,,,,,,,,,,,NME2P1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000069,"[""CDC2L2 kinase domain""]",,Cyclin-dependent kinase 11A; CDC2L2; CDC2L3; CDK11A; CDK11-p110; CDK11-p46; CDK11-p58; MGC131975; p58GTA; PITSLRE,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Cyclin-dependent kinase 11A; CDC2L2; CDC2L3; CDK11A; CDK11-p110; CDK11-p46; CDK11-p58; MGC131975; p58GTA; PITSLRE,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000069,,,,,,,,,,,,,,,,,,,200072,,,,,,,,,CDC2L2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2706,"[""synovium cancer""]",,,false,,,http://purl.obolibrary.org/obo/DOID_201,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2706,,,,UMLS_CUI:C1334624|NCI:C6531,malignant tumor of Synovium,,disease_ontology,,DOID:2706,,,,,,,,,,,,,,,,,,,synovium cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400465,"[""Nav1.2/SCN2A subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400369,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400465,,,,,,,,,,,,,,,,,,,,,,,,,,,,Nav1.2/SCN2A subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000370,"[""PLK4 kinase domain""]",,Serine/threonine-protein kinase PLK4; polo-like kinase 4 (Drosophila); PLK4; SAK; STK18,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase PLK4; polo-like kinase 4 (Drosophila); PLK4; SAK; STK18,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000370,,,,,,,,,,,,,,,,,,,200353,,,,,,,,,PLK4 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100826,"[""Chemokine xc receptor 1""]",,"A chemokine XC receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46094] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A chemokine XC receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46094] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100826,,,,https://pharos.nih.gov/idg/targets/P46094,,,,,,,,,,,,,XCR1,CCXCR1|GPR5,,P46094,,,,,,,,Chemokine xc receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004238,"[""interstitial cell""]",,"The cells of the connective tissue of the ovary and testis (Leydig cells), which furnish the internal secretion of those structures.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000421,,,,,,,,"The cells of the connective tissue of the ovary and testis (Leydig cells), which furnish the internal secretion of those structures.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004238,,,,,,,BrendaTissueOBO,,BTO:0004238,,,,,,,,,,,,,,,,,,,interstitial cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003642,"[""Hca-F cell""]",,Murine hepatocarcinoma cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0000578|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Murine hepatocarcinoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003642,,,,,,,BrendaTissueOBO,,BTO:0003642,,,,,,,,,,,,,,,,,,,Hca-F cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300096,"[""C-X3-C chemokine receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300031,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300096,,,,,,,,,,,,,,,,,,,,,,,,,,,,C-X3-C chemokine receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400401,"[""ClC-7/CLCN7 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400341,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400401,,,,,,,,,,,,,,,,,,,,,,,,,,,,ClC-7/CLCN7 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2536,"[""chronic inflammatory demyelinating polyneuritis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2537,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2536,,,,ICD10CM:G61.81|NCI:C84636|SNOMEDCT_US_2016_03_01:444728005|UMLS_CUI:C0393819|ICD9CM:357.81|MESH:D020277|SNOMEDCT_US_2016_03_01:128209004,,,disease_ontology,,DOID:2536,,,,,,,,,,,,,,,,,,,chronic inflammatory demyelinating polyneuritis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4998,"[""trichorhinophalangeal syndrome type II""]",,"An autosomal dominant disease that has_material_basis_in mutation of the EXT1 and TRPS1 gene which results_in multiple exostosis along with short stature and cone-shaped ends located_in epiphysis. The disease has_symptom sparse scalp hair, has_symptom thin upper lip, has_symptom rounded nose.",false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,"An autosomal dominant disease that has_material_basis_in mutation of the EXT1 and TRPS1 gene which results_in multiple exostosis along with short stature and cone-shaped ends located_in epiphysis. The disease has_symptom sparse scalp hair, has_symptom thin upper lip, has_symptom rounded nose.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4998,,,,SNOMEDCT_US_2016_03_01:41069008|OMIM:150230|MESH:D015826|UMLS_CUI:C0023003|SNOMEDCT_US_2016_03_01:239017000|NCI:C75118,Trichorhinophalangeal dysplasia type II|Langer-Giedion syndrome,,disease_ontology,,DOID:4998,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,trichorhinophalangeal syndrome type II,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000083,"[""LEU89 in PLK4""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000083,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU89 in PLK4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050646,"[""distal arthrogryposis""]",,A muscle tissue disease characterized by congenital joint contractures of hand and feet.,false,,,http://purl.obolibrary.org/obo/DOID_66,,,,,,,,A muscle tissue disease characterized by congenital joint contractures of hand and feet.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050646,,,,OMIM:609128|OMIM:601680|ORDO:1147|OMIM:108200|OMIM:193700|OMIM:114300|OMIM:187370|OMIM:614335|OMIM:121050|OMIM:108145|OMIM:615065|OMIM:108120|ORDO:97120|OMIM:158300|OMIM:178110|OMIM:121070,Sheldon-Hall syndrome|Arthrogryposis Multiplex Congenita|Freeman-Sheldon syndrome variant|Freeman-Sheldon syndrome,,disease_ontology,,DOID:0050646,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,distal arthrogryposis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050647,"[""Arts syndrome""]",,"An X-linked disease that is characterized by profound congenital sensorineural hearing impairment, early-onset hypotonia, delayed motor development, mild to moderate intellectual disability, ataxia, and increased risk of infection and has_material_basis_in mutations of the PRPS1 gene.",false,,,http://purl.obolibrary.org/obo/DOID_0060309,,,,,,,,"An X-linked disease that is characterized by profound congenital sensorineural hearing impairment, early-onset hypotonia, delayed motor development, mild to moderate intellectual disability, ataxia, and increased risk of infection and has_material_basis_in mutations of the PRPS1 gene.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050647,,,,MESH:C535388|UMLS_CUI:C0796028|ICD10CM:E79.8|ORDO:1187|OMIM:301835,syndromic X-linked mental retardation Arts type|fatal X-linked ataxia with deafness and loss of vision|syndromic X-linked mental retardation 18|ARTS|MRXS18|MRXSARTS|Lethal ataxia with deafness and optic atrophy,,disease_ontology,,DOID:0050647,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Arts syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200384,"[""OR51A2 gene""]",,"An olfactory receptor 51A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 51A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200384,,,,,,,,,,,,,,,,401667,OR51A2,,,,,,,,,,,OR51A2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400414,"[""GRID1 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400414,,,,,,,,,,,,,,,,,,,,,,,,,,,,GRID1 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000713,"[""leaf""]",,"A lateral outgrowth from a plant stem that is typically a flattened expanded variably shaped greenish organ, constitutes a unit of the foliage, and functions primarily in food manufacture by photosynthesis.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A lateral outgrowth from a plant stem that is typically a flattened expanded variably shaped greenish organ, constitutes a unit of the foliage, and functions primarily in food manufacture by photosynthesis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000713,,,,,,,BrendaTissueOBO,,BTO:0000713,,,,,,,,,,,,,,,,,,,leaf,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000415,"[""TYR288 in IRAK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_46858,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000415,,,,,,,,,,,,,,,,,,,,,,,,,,,,TYR288 in IRAK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000066,"[""LEU2026 in ROS1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000066,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU2026 in ROS1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300006,"[""Other 7TM proteins""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300001,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300006,,,,,,,,,,,,,,,,,,,,,,,,,,,,Other 7TM proteins,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400483,"[""LTrpC subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400360,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400483,,,,,,,,,,,,,,,,,,,,,,,,,,,,LTrpC subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00400003,"[""Tclin""]",,These targets have activities in DrugCentral (ie. approved drugs) with known mechanism of action.|Tclin,false,,,http://www.drugtargetontology.org/dto/DTO_00400001,,,,,,,,These targets have activities in DrugCentral (ie. approved drugs) with known mechanism of action.|Tclin,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00400003,,,,,,,,,,,,,,,,,,,,,,,,,,,,Tclin,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000241,"[""LTK kinase domain""]",,Leukocyte receptor tyrosine kinase; LTK; TYK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Leukocyte receptor tyrosine kinase; LTK; TYK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000241,,,,,,,,,,,,,,,,,,,200231,,,,,,,,,LTK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005754,"[""choroid plexus cancer cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005754,Marion,2015-09-13T14:00:56Z,,,,,BrendaTissueOBO,,BTO:0005754,,,,,,,,,,,,,,,,,,,choroid plexus cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100067,"[""Cysteinyl leukotriene receptor 1""]",,"A cysteinyl leukotriene receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y271] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300033,,,,,,,,"A cysteinyl leukotriene receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y271] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100067,,,,https://pharos.nih.gov/idg/targets/Q9Y271,,,,,,,,,,,,,CYSLTR1,CYSLT1,,Q9Y271,,,,,,,,Cysteinyl leukotriene receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10952,"[""nephritis""]",,A kidney disease that is characterized by an inflammation of the kidneys.,false,,,http://purl.obolibrary.org/obo/DOID_557,,,,,,,,A kidney disease that is characterized by an inflammation of the kidneys.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10952,,,,NCI:C26833|MESH:D009393|UMLS_CUI:C0027697|ICD10CM:N08|SNOMEDCT_US_2016_03_01:274107001|ICD10CM:N05|SNOMEDCT_US_2016_03_01:155853001|SNOMEDCT_US_2016_03_01:266615001|SNOMEDCT_US_2016_03_01:52845002,,,disease_ontology,,DOID:10952,,,,,,,,,,,,,,,,,,,nephritis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10955,"[""strongyloidiasis""]",,"A parasitic helminthiasis infectious disease that involves infection of the intestine, lungs, skin and central nervous system with nematode Strongyloides stercoralis.",false,,,http://purl.obolibrary.org/obo/DOID_883,,,,,,,,"A parasitic helminthiasis infectious disease that involves infection of the intestine, lungs, skin and central nervous system with nematode Strongyloides stercoralis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10955,,,DOID:0050008,SNOMEDCT_US_2016_03_01:187177001|UMLS_CUI:C0038463|ICD9CM:127.2|MESH:D013322|ICD10CM:B78|SNOMEDCT_US_2016_03_01:187537002|SNOMEDCT_US_2016_03_01:1214006|ICD10CM:B78.9,disseminated strongyloidiasis|Infection by Strongyloides (disorder),,disease_ontology,,DOID:10955,,,,,,,,,,,,,,,,,,,strongyloidiasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100433,"[""Olfactory receptor 52n5""]",,"An olfactory receptor 52N5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH56] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 52N5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH56] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100433,,,,https://pharos.nih.gov/idg/targets/Q8NH56,,,,,,,,,,,,,OR52N5,,,Q8NH56,,,,,,,,Olfactory receptor 52n5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2965,"[""bursitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_381,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2965,,,,SNOMEDCT_US_2016_03_01:84017003|MESH:D002062|ICD10CM:M71.9|SNOMEDCT_US_2016_03_01:202935009|SNOMEDCT_US_2016_03_01:156686008|UMLS_CUI:C0006444|NCI:C94407|SNOMEDCT_US_2016_03_01:268000007|SNOMEDCT_US_2016_03_01:156677003,,,disease_ontology,,DOID:2965,,,,,,,,,,,,,,,,,,,bursitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001836,"[""thymic epithelium""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000416,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001836,,,,,,,BrendaTissueOBO,,BTO:0001836,,,,,,,,,,,,,,,,,,,thymic epithelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300342,"[""Intracellular chloride channel (clic) family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300342,,,,,,,,,,,,,,,,,,,,,,,,,,,,Intracellular chloride channel (clic) family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5605,"[""breast medullary carcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3458,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5605,,,,NCI:C9119|UMLS_CUI:C0860580,Medullary breast carcinoma with lymphoid Stroma,,disease_ontology,medullary carcinoma of breast,DOID:5605,,,,,,,,,,,,,,,,,,,breast medullary carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001008,"[""PBMC cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001035,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001008,,,,,,,BrendaTissueOBO,peripheral blood mononuclear cell cell line,BTO:0001008,,,,,,,,,,,,,,,,,,,PBMC cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/UBERON_0000945,"[""stomach""]",stomach chamber,"An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,http://en.wikipedia.org/wiki/Stomach|http://www.snomedbrowser.com/Codes/Details/181246003|http://linkedlifedata.com/resource/umls/id/C0038351|MA:0000353|EFO:0000837|EV:0100070|GAID:293|AAO:0000579|ncithesaurus:Stomach|BTO:0001307|TAO:0002121|UMLS:C0038351|VHOG:0000408|EMAPA:18889|ANISEED:1235297|MAT:0000051|XAO:0000128|EHDAA2:0001915|galen:Stomach|CALOHA:TS-0980|MESH:A03.492.766|FMA:7148|OpenCyc:Mx4rvVjlqpwpEbGdrcN5Y29ycA|EMAPA:17021|MIAA:0000051|EHDAA:2993,"An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium.",,http://upload.wikimedia.org/wikipedia/commons/thumb/e/e0/Stomach_diagram.svg/200px-Stomach_diagram.svg.png|http://upload.wikimedia.org/wikipedia/commons/e/e0/Stomach_diagram.svg,,,,,,,,Portion of alimentary canal with increased circular and longitudinal smooth muscle. Bounded posteriorly by the pyloric sphincter. Mucosal lining has increased folding.[AAO],,,,,,,,,,,,,,,,,,,,,,,,,,,stomach chamber,uberon,anterior intestine|Ventricular|gaster|ventriculus|mesenteron,,"It appears that the stomach has an ancient origin. The stomach first appears in the fish lineage. The prevertebrate chordates do not have a true stomach, whereas the cartilaginous and bony fish do. Although most fish do have a true stomach, some fish species appear to have lost the stomach secondarily. The remaining vertebrate lineages do have a true stomach (at least in the adult animal), although there is great variation in the size and shape of the stomach.[well established][VHOG]",,,,,,,,,,,,,,,,,,,,,,,,UBERON:0000945,,,"Taxon notes: We restrict this to the vertebrate specific structure - see the grouping class 'food storage organ' for analogous structures in other species. Teleosts: Zebrafish is functionally stomach-less, but may retain ontogenic footprint. Although the precise shape and size of the stomach varies widely among different vertebrates, the relative positions of the oesophageal and duodenal openings remain relatively constant. As a result, the organ always curves somewhat to the left before curving back to meet the pyloric sphincter. However, lampreys, hagfishes, chimaeras, lungfishes, and some teleost fish have no stomach at all, with the oesophagus opening directly into the intestine. The gastric lining is usually divided into two regions, an anterior portion lined by fundic glands, and a posterior with pyloric glands. Cardiac glands are unique to mammals, and even then are absent in a number of species. The distributions of these glands vary between species, and do not always correspond with the same regions as in man. Furthermore, in many non-human mammals, a portion of the stomach anterior to the cardiac glands is lined with epithelium essentially identical to that of the oesophagus. Ruminants, in particular, have a complex stomach, the first three chambers of which are all lined with oesophageal mucosa [WP:Stomach#In_other_animals]",,stomach,,UBERON:0000945,,http://purl.obolibrary.org/obo/uberon.owl,http://purl.obolibrary.org/obo/uberon/core#efo_slim|http://purl.obolibrary.org/obo/uberon/core#organ_slim|http://purl.obolibrary.org/obo/uberon/core#vertebrate_core|http://purl.obolibrary.org/obo/uberon/core#major_organ|http://purl.obolibrary.org/obo/uberon/core#uberon_slim,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1143,"[""exotropia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_540,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1143,,,,UMLS_CUI:C0015310|ICD9CM:378.10|ICD10CM:H50.1|SNOMEDCT_US_2016_03_01:399252000|MESH:D005099|SNOMEDCT_US_2016_03_01:75400001|SNOMEDCT_US_2016_03_01:399054005|NCI:C34601|SNOMEDCT_US_2016_03_01:194098009|SNOMEDCT_US_2016_03_01:194086004|SNOMEDCT_US_2016_03_01:155194007|ICD10CM:H50.10|ICD9CM:378.1,Divergent concomitant strabismus|Divergent Strabismus,,disease_ontology,,DOID:1143,,,,,,,,,,,,,,,,,,,exotropia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200339,"[""MAP2K6 gene""]",,"This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400194,,,,,,,,"This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200339,,,,,,,,,,,,,,,,5608,MAP2K6,MEK6|MKK6|PRKMK6,,,,,,,,,,MAP2K6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4480,"[""achondroplasia""]",,An osteochondrodysplasia that results_in dwarfism which has_material_basis_in abnormal ossification of cartilage in located_in long bone.,false,,,http://purl.obolibrary.org/obo/DOID_2256,,,,,,,,An osteochondrodysplasia that results_in dwarfism which has_material_basis_in abnormal ossification of cartilage in located_in long bone.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4480,,,,UMLS_CUI:C0001080|SNOMEDCT_US_2016_03_01:205467007|NCI:C34345|ICD10CM:Q77.4|SNOMEDCT_US_2016_03_01:86268005|SNOMEDCT_US_2016_03_01:190584003|OMIM:100800|SNOMEDCT_US_2016_03_01:248299001|SNOMEDCT_US_2016_03_01:268350005|MESH:D000130|SNOMEDCT_US_2016_03_01:268273004,Achondroplastic physique|Chondrodystrophia|osteosclerosis congenita,,disease_ontology,,DOID:4480,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,achondroplasia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400322,"[""Nucleoside kinase gene""]",,A Nucleoside kinase is a kinase enzyme that catalyzes the phosphorylation of a nucleoside substrate.,false,,,http://www.drugtargetontology.org/dto/DTO_03400103,,,,,,,,A Nucleoside kinase is a kinase enzyme that catalyzes the phosphorylation of a nucleoside substrate.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400322,,,,,,,,,,,,,,,,,,,,,,,,,,,,Nucleoside kinase gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100498,"[""Serine/threonine-protein kinase 24""]",,"serine/threonine-protein kinase 24 (MST3)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase 24 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y6E0] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300297,,,,,,,,"serine/threonine-protein kinase 24 (MST3)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase 24 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y6E0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100498,,,,https://pharos.nih.gov/idg/targets/Q9Y6E0,,,,,,,,,,,,,STK24,MST3|STK3,,Q9Y6E0,,,,,,,,Serine/threonine-protein kinase 24,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003912,"[""IMCD cell""]",,Renal inner medullary collecting duct (IMCD) cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002658|http://purl.obolibrary.org/obo/BTO_0001526,,,,,,,,Renal inner medullary collecting duct (IMCD) cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003912,,,,,,,BrendaTissueOBO,,BTO:0003912,,,,,,,,,,,,,,,,,,,IMCD cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9206,"[""Barrett's esophagus""]",,,false,,,http://purl.obolibrary.org/obo/DOID_6050,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9206,,,,OMIM:614266|NCI:C2891|SNOMEDCT_US_2016_03_01:196603007|SNOMEDCT_US_2016_03_01:196609006|SNOMEDCT_US_2016_03_01:155679007|ICD10CM:K22.70|ICD9CM:530.85|SNOMEDCT_US_2016_03_01:302914006|ICD10CM:K22.7|EFO:0000280|UMLS_CUI:C0004763|SNOMEDCT_US_2016_03_01:235597001|SNOMEDCT_US_2016_03_01:76355008|MESH:D001471,Barrett's oesophagus|Barrett's esophagus with esophagitis|Barrett's ulcer of esophagus|Barrett esophagus|CLE|(ulcerative esophagitis) or (Barrett's esophagus)|Barretts syndrome,,disease_ontology,,DOID:9206,,,,,,,,,,,,,,,,,,,Barrett's esophagus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100034,"[""L747-S752del and S753 in EGFR(L747-S752del, P753S)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100034,,,,,,,,,,,,,,,,,,,,,,,,,,,,"L747-S752del and S753 in EGFR(L747-S752del, P753S)",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000894,"[""myelin""]",,A soft white somewhat fatty material that forms a thick myelin sheath about the protoplasmic core of a myelinated nerve fiber.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A soft white somewhat fatty material that forms a thick myelin sheath about the protoplasmic core of a myelinated nerve fiber.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000894,,,,,,,BrendaTissueOBO,,BTO:0000894,,,,,,,,,,,,,,,,,,,myelin,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200377,"[""OR4A16 gene""]",,"An olfactory receptor 4A16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH70] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4A16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH70] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200377,,,,,,,,,,,,,,,,81327,OR4A16,,,,,,,,,,,OR4A16 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001440,"[""venom gland""]",,The venom gland of snakes is in actual fact a modified salivary gland and is linked to the groove in the fangs by a duct; A bee has a poison gland in her abdomen.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000765,,,,,,,,The venom gland of snakes is in actual fact a modified salivary gland and is linked to the groove in the fangs by a duct; A bee has a poison gland in her abdomen.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001440,,,,,,,BrendaTissueOBO,poison gland,BTO:0001440,,,,,,,,,,,,,,,,,,,venom gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100166,"[""Probable g-protein coupled receptor 176""]",,"A G-protein coupled receptor 176 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14439] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300053,,,,,,,,"A G-protein coupled receptor 176 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14439] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100166,,,,https://pharos.nih.gov/idg/targets/Q14439,,,,,,,,,,,,,GPR176,,,Q14439,,,,,,,,Probable g-protein coupled receptor 176,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004973,"[""Hodgkin lymphoma cell line""]",,A disease of the lymph nodes named after the English physician Thomas Hodgkin.,false,,,http://purl.obolibrary.org/obo/BTO_0000104|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A disease of the lymph nodes named after the English physician Thomas Hodgkin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004973,Marion Gremse,2010-10-28T01:35:51Z,,,,,BrendaTissueOBO,,BTO:0004973,,,,,,,,,,,,,,,,,,,Hodgkin lymphoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200800,"[""TBXA2R gene""]",,"A thromboxane A2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21731] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A thromboxane A2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21731] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200800,,,,,,,,,,,,,,,,6915,TBXA2R,,,,,,,,,,,TBXA2R gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300280,"[""RSK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300178,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300280,,,,,,,,,,,,,,,,,,,,,,,,,,,,RSK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8457,"[""pellagra""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5113,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8457,,,,ICD10CM:E52|ICD9CM:265.2|SNOMEDCT_US_2016_03_01:267491008|SNOMEDCT_US_2016_03_01:154725000|SNOMEDCT_US_2016_03_01:56550003|MESH:D010383|SNOMEDCT_US_2016_03_01:238127001|SNOMEDCT_US_2016_03_01:418279001|SNOMEDCT_US_2016_03_01:418186002|UMLS_CUI:C0030783,Pellagra|Niacin deficiency|Niacin-tryptophan deficiency,,disease_ontology,,DOID:8457,,,,,,,,,,,,,,,,,,,pellagra,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300510,"[""GABRA5 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300510,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRA5 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400005,"[""Class F frizzled-type gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400001,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400005,,,,,,,,,,,,,,,,,,,,,,,,,,,,Class F frizzled-type gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050563,"[""nonsyndromic deafness""]",,"An auditory system disease that is associated with permanent hearing loss caused by damage to structures in the inner ear and/or the middle ear, which is not associated with other signs and symptoms.",false,,,http://purl.obolibrary.org/obo/DOID_2742,,,,,,,,"An auditory system disease that is associated with permanent hearing loss caused by damage to structures in the inner ear and/or the middle ear, which is not associated with other signs and symptoms.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050563,,,,,nonsyndromic hearing loss|nonsyndromic hereditary hearing loss,,disease_ontology,,DOID:0050563,,,,,,,,,,,,,,,,,,,nonsyndromic deafness,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050564,"[""autosomal dominant nonsyndromic deafness""]",,A nonsyndromic deafness characterized by an autosomal dominant inheritance mode.,false,,,http://purl.obolibrary.org/obo/DOID_0050563,,,,,,,,A nonsyndromic deafness characterized by an autosomal dominant inheritance mode.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050564,,,,ORDO:90635|ICD10CM:H90.3|OMIM:PS124900,autosomal dominant deafness,,disease_ontology,,DOID:0050564,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,autosomal dominant nonsyndromic deafness,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050566,"[""X-linked nonsyndromic deafness""]",,A nonsyndromic deafness characterized by an X-linked inheritance mode.,false,,,http://purl.obolibrary.org/obo/DOID_0050563,,,,,,,,A nonsyndromic deafness characterized by an X-linked inheritance mode.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050566,,,,OMIM:300030|OMIM:300614|ICD10CM:H90.3|OMIM:300066|OMIM:304400|OMIM:300914|ORDO:90625|OMIM:304500,X-linked deafness,,disease_ontology,,DOID:0050566,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,X-linked nonsyndromic deafness,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050567,"[""orofacial cleft""]",,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",false,,,http://purl.obolibrary.org/obo/DOID_0080015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050567,,,,OMIM:119530|OMIM:613857|OMIM:613705|OMIM:600757|OMIM:608371|OMIM:602966|OMIM:608864|OMIM:615892|OMIM:612858|OMIM:610361|OMIM:608874|OMIM:600625,,,disease_ontology,,DOID:0050567,,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,orofacial cleft,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050569,"[""Seckel syndrome""]",,An autosomal recessive disease characterized by intrauterine growth retardation and postnatal dwarfism with microcephaly and intellectual disability.,false,,,http://purl.obolibrary.org/obo/DOID_0050737,,,,,,,,An autosomal recessive disease characterized by intrauterine growth retardation and postnatal dwarfism with microcephaly and intellectual disability.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050569,,,,ORDO:808|OMIM:210600|OMIM:615807|OMIM:606744|ICD10CM:Q87.1|OMIM:613823|OMIM:613676|OMIM:614728|OMIM:614851,Harper's syndrome|microcephalic primordial dwarfism|bird-headed dwarfism|Virchow-Seckel dwarfism,,disease_ontology,,DOID:0050569,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,Seckel syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100025,"[""Alpha-protein kinase 3""]",,"An alpha-protein kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96L96] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300123,,,,,,,,"An alpha-protein kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96L96] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100025,,,,https://pharos.nih.gov/idg/targets/Q96L96,,,,,,,,,,,,,ALPK3,KIAA1330|MAK,,Q96L96,,,,,,,,Alpha-protein kinase 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000203,"[""MET79 in NEK3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000203,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET79 in NEK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100023,"[""I841 in FLT3(N841I)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100023,,,,,,,,,,,,,,,,,,,,,,,,,,,,I841 in FLT3(N841I),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200749,"[""PROKR1 gene""]",,"A prokineticin receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TCW9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A prokineticin receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TCW9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200749,,,,,,,,,,,,,,,,10887,PROKR1,GPR73|PKR1,,,,,,,,,,PROKR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200144,"[""PTK2 gene""]",,"This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq, Dec 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400155,,,,,,,,"This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq, Dec 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200144,,,,,,,,,,,,,,,,5747,PTK2,FAK|FAK1,,,,,,,,,,PTK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400352,"[""Voltage-gated proton channel (vpc) family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400352,,,,,,,,,,,,,,,,,,,,,,,,,,,,Voltage-gated proton channel (vpc) family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100050,"[""Tyrosine-protein kinase btk""]",,"tyrosine-protein kinase btk (BTK)  with  no mutation  in a nonphosphorylated state|A tyrosine-protein kinase BTK that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q06187] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300133,,,,,,,,"tyrosine-protein kinase btk (BTK)  with  no mutation  in a nonphosphorylated state|A tyrosine-protein kinase BTK that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q06187] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100050,,,,https://pharos.nih.gov/idg/targets/Q06187,,,,,,,,,,,,,BTK,AGMX1|ATK|BPK,,Q06187,,,,,,,,Tyrosine-protein kinase btk,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000480,"[""forestomach""]",,"Any of the first three stomachs of a ruminant, i.e., the rumen, reticulum, or omasum.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0000945|http://purl.obolibrary.org/obo/BTO_0001307,,,,,,,,"Any of the first three stomachs of a ruminant, i.e., the rumen, reticulum, or omasum.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000480,,,,,,,BrendaTissueOBO,,BTO:0000480,,,,,,,,,,,,,,,,,,,forestomach,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300349,"[""Phospholemman (plm) family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300349,,,,,,,,,,,,,,,,,,,,,,,,,,,,Phospholemman (plm) family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200109,"[""DGKQ gene""]",,"The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03491025,,,,,,,,"The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200109,,,,,,,,,,,,,,,,1609,DGKQ,DAGK4,,,,,,,,,,DGKQ gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200184,"[""GPR21 gene""]",,"A G-protein coupled receptor 21 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99679] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400053,,,,,,,,"A G-protein coupled receptor 21 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99679] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200184,,,,,,,,,,,,,,,,2844,GPR21,,,,,,,,,,,GPR21 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200084,"[""CLIC6 gene""]",,"This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been described, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400342,,,,,,,,"This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been described, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200084,,,,,,,,,,,,,,,,54102,CLIC6,CLIC1L,,,,,,,,,,CLIC6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200205,"[""PRKACB gene""]",,"The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400169,,,,,,,,"The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200205,,,,,,,,,,,,,,,,5567,PRKACB,,,,,,,,,,,PRKACB gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200273,"[""LRRK2 gene""]",,"This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400184,,,,,,,,"This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200273,,,,,,,,,,,,,,,,120892,LRRK2,PARK8,,,,,,,,,,LRRK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100602,"[""Olfactory receptor 4N4""]",,"An olfactory receptor 4N4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N0Y3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4N4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N0Y3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100602,,,,https://pharos.nih.gov/idg/targets/Q8N0Y3,,,,,,,,,,,,,OR4N4,,,Q8N0Y3,,,,,,,,Olfactory receptor 4N4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_63000003,"[""Alpha_kinase""]",,"A Pfam protein family that is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases  and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.",false,,,http://www.drugtargetontology.org/dto/DTO_63000000,,,,,,,,"A Pfam protein family that is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases  and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.",http://pfam.xfam.org/family/Alpha_kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_63000003,,,,,,,,,,,,,,,,,,,,,,,,,,,,Alpha_kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13034,"[""relapsing fever""]",,"A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia, which is transmitted_by tick or transmitted_by body louse.",false,,,http://purl.obolibrary.org/obo/DOID_0050338,,,,,,,,"A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia, which is transmitted_by tick or transmitted_by body louse.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13034,,,,ICD9CM:087|SNOMEDCT_US_2016_03_01:186820006|ICD10CM:A68|SNOMEDCT_US_2016_03_01:187374004|ICD10CM:A68.9|UMLS_CUI:C0035021|ICD9CM:087.9|SNOMEDCT_US_2016_03_01:186822003|SNOMEDCT_US_2016_03_01:420079008|MESH:D012061|SNOMEDCT_US_2016_03_01:46107006,,,disease_ontology,,DOID:13034,http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease,,,,,,,,,,,,,,,,,,relapsing fever,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13036,"[""tick-borne relapsing fever""]",,"A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia hermsii, has_material basis_in Borrelia parkeri or has_material basis_in Borrelia duttoni, which are transmitted_by soft ticks (Ornithodoros parkeri and Ornithodoros hermsii). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy.",false,,,http://purl.obolibrary.org/obo/DOID_13034,,,,,,,,"A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia hermsii, has_material basis_in Borrelia parkeri or has_material basis_in Borrelia duttoni, which are transmitted_by soft ticks (Ornithodoros parkeri and Ornithodoros hermsii). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13036,,,,ICD10CM:A68.1|NCI:C34976|SNOMEDCT_US_2016_03_01:186821005|UMLS_CUI:C0035022|SNOMEDCT_US_2016_03_01:10301003|ICD9CM:087.1,"Tick-borne relapsing fever NOS (disorder)|Tick-borne relapsing fever (disorder)|Relapsing fever, tick-borne",,disease_ontology,,DOID:13036,http://purl.obolibrary.org/obo/doid#tick-borne_infectious_disease|http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease|http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,tick-borne relapsing fever,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100708,"[""Olfactory receptor 8u1""]",,"An olfactory receptor 8U1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH10] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 8U1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH10] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100708,,,,https://pharos.nih.gov/idg/targets/Q8NH10,,,,,,,,,,,,,OR8U1,,,Q8NH10,,,,,,,,Olfactory receptor 8u1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100020,"[""Atypical chemokine receptor 4""]",,"A C-C chemokine receptor type 11 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NPB9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300031,,,,,,,,"A C-C chemokine receptor type 11 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NPB9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100020,,,,https://pharos.nih.gov/idg/targets/Q9NPB9,,,,,,,,,,,,,ACKR4,CCBP2|CCR11|CCRL1|VSHK1,,Q9NPB9,,,,,,,,Atypical chemokine receptor 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11353,"[""bladder diverticulum""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_365,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11353,,,,SNOMEDCT_US_2016_03_01:156977001|SNOMEDCT_US_2016_03_01:252004007|UMLS_CUI:C0156273|SNOMEDCT_US_2016_03_01:268335001|SNOMEDCT_US_2016_03_01:21853005|SNOMEDCT_US_2016_03_01:197869001|SNOMEDCT_US_2016_03_01:197866008|ICD9CM:596.3|ICD10CM:N32.3|SNOMEDCT_US_2016_03_01:155888001|OMIM:109820|MESH:C562406,Diverticulum of bladder|Diverticulum - bladder,,disease_ontology,,DOID:11353,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,bladder diverticulum,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000284,"[""PHE80 in CDK5""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000284,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE80 in CDK5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100311,"[""Maternal embryonic leucine zipper kinase""]",,"A maternal embryonic leucine zipper kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14680] |maternal embryonic leucine zipper kinase (MELK)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300291,,,,,,,,"A maternal embryonic leucine zipper kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14680] |maternal embryonic leucine zipper kinase (MELK)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100311,,,,https://pharos.nih.gov/idg/targets/Q14680,,,,,,,,,,,,,MELK,KIAA0175,,Q14680,,,,,,,,Maternal embryonic leucine zipper kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100217,"[""G-protein coupled receptor 98""]",,"A G-protein coupled receptor 98 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WXG9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,"A G-protein coupled receptor 98 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WXG9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100217,,,,https://pharos.nih.gov/idg/targets/Q8WXG9,,,,,,,,,,,,,GPR98,ADGRV1|KIAA0686|KIAA1943|MASS1|VLGR1,,Q8WXG9,,,,,,,,G-protein coupled receptor 98,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2377,"[""multiple sclerosis""]",,A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.,false,,,http://purl.obolibrary.org/obo/DOID_3213,,,,,,,,A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2377,,,,ICD10CM:G35|UMLS_CUI:C0026769|OMIM:614810|OMIM:126200|ICD9CM:340|SNOMEDCT_US_2016_03_01:192930001|OMIM:612595|SNOMEDCT_US_2016_03_01:155023009|MESH:D009103|EFO:0003885|OMIM:612596|NCI:C3243|SNOMEDCT_US_2016_03_01:24700007|OMIM:612594|SNOMEDCT_US_2016_03_01:192928003,Generalized multiple sclerosis (disorder)|insular sclerosis,,disease_ontology,,DOID:2377,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,multiple sclerosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100368,"[""Olfactory receptor 2t10""]",,"An olfactory receptor 2T10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2T10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100368,,,,https://pharos.nih.gov/idg/targets/Q8NGZ9,,,,,,,,,,,,,OR2T10,,,Q8NGZ9,,,,,,,,Olfactory receptor 2t10,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100319,"[""Olfactory receptor 10P1""]",,"An olfactory receptor 10P1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10P1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100319,,,,https://pharos.nih.gov/idg/targets/Q8NGE3,,,,,,,,,,,,,OR10P1,OR10P1P|OR10P2P|OR10P3P,,Q8NGE3,,,,,,,,Olfactory receptor 10P1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400326,"[""Nucleotide kinase gene""]",,A Nucleotide kinase is a kinase enzyme that catalyzes the phosphorylation of a nucleotide substrate.,false,,,http://www.drugtargetontology.org/dto/DTO_03400103,,,,,,,,A Nucleotide kinase is a kinase enzyme that catalyzes the phosphorylation of a nucleotide substrate.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400326,,,,,,,,,,,,,,,,,,,,,,,,,,,,Nucleotide kinase gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117476,"[""Fushi tarazu f1-like receptors""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00102000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117476,,,,,,,,,,,,,,,,,,,,,,,,,,,,Fushi tarazu f1-like receptors,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400278,"[""PKC eta subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400175,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400278,,,,,,,,,,,,,,,,,,,,,,,,,,,,PKC eta subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003798,"[""multicellular trichome""]",,Trichome that consists of several cells.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001395,,,,,,,,Trichome that consists of several cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003798,,,,,,,BrendaTissueOBO,,BTO:0003798,,,,,,,,,,,,,,,,,,,multicellular trichome,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400249,"[""ABC1-A subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400120,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400249,,,,,,,,,,,,,,,,,,,,,,,,,,,,ABC1-A subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9973,"[""substance dependence""]",,A substance-related disorder that involves the continued use of alcohol or other drugs despite problems related to use of the substance.,false,,,http://purl.obolibrary.org/obo/DOID_303,,,,,,,,A substance-related disorder that involves the continued use of alcohol or other drugs despite problems related to use of the substance.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9973,,,,UMLS_CUI:C0439857|SNOMEDCT_US_2016_03_01:103326000|SNOMEDCT_US_2016_03_01:255338002|NCI:C35458,,,disease_ontology,,DOID:9973,,,,,,,,,,,,,,,,,,,substance dependence,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004254,"[""cancer stem cell""]",,"Cancer stem cells are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer sample. CSCs are tumorigenic.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Cancer stem cells are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer sample. CSCs are tumorigenic.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004254,,,,,,,BrendaTissueOBO,Krebsstammzelle|CSC cell,BTO:0004254,,,,,,,,,,,,,,,,,,,cancer stem cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100377,"[""Serine/threonine-protein kinase osr1""]",,"serine/threonine-protein kinase osr1 (OSR1)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase OSR1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95747] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300302,,,,,,,,"serine/threonine-protein kinase osr1 (OSR1)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase OSR1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95747] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100377,,,,https://pharos.nih.gov/idg/targets/O95747,,,,,,,,,,,,,OXSR1,KIAA1101|OSR1,,O95747,,,,,,,,Serine/threonine-protein kinase osr1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200294,"[""OR10AC1 gene""]",,"An olfactory receptor 10AC1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH08] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10AC1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH08] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200294,,,,,,,,,,,,,,,,392133,OR10AC1,OR10AC1P,,,,,,,,,,OR10AC1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300579,"[""TRPC4 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300482,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300579,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPC4 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004699,"[""posterior pharynx""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004699,mgr,2010-05-16T09:08:26Z,,,,,BrendaTissueOBO,,BTO:0004699,,,,,,,,,,,,,,,,,,,posterior pharynx,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300374,"[""5-hydroxytryptamine receptor subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300328,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300374,,,,,,,,,,,,,,,,,,,,,,,,,,,,5-hydroxytryptamine receptor subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200508,"[""OR2A1; OR2A42 gene""]",,An olfactory receptor 2A1/2A42 that is encoded in the genome of human. ,false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,An olfactory receptor 2A1/2A42 that is encoded in the genome of human. ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200508,,,,,,,,,,,,,,,,346528|402317,OR2A1,OR2A42,,,,,,,,,,OR2A1; OR2A42 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000504,"[""pancreatic juice""]",,"The liquid secretion of the exocrine pancreas, which is discharged into the duodenum.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000346,,,,,,,,"The liquid secretion of the exocrine pancreas, which is discharged into the duodenum.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000504,,,,,,,BrendaTissueOBO,succus pancreaticus,BTO:0000504,,,,,,,,,,,,,,,,,,,pancreatic juice,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100427,"[""Olfactory receptor 52l1""]",,"An olfactory receptor 52L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 52L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100427,,,,https://pharos.nih.gov/idg/targets/Q8NGH7,,,,,,,,,,,,,OR52L1,,,Q8NGH7,,,,,,,,Olfactory receptor 52l1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300031,"[""Chemokine receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300031,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chemokine receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300514,"[""GABRB3 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300514,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRB3 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200023,"[""ANO2 gene""]",,"ANO2 belongs to a family of calcium-activated chloride channels (CaCCs) (reviewed by Hartzell et al., 2009 [PubMed 19015192]).[supplied by OMIM, Jan 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400329,,,,,,,,"ANO2 belongs to a family of calcium-activated chloride channels (CaCCs) (reviewed by Hartzell et al., 2009 [PubMed 19015192]).[supplied by OMIM, Jan 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200023,,,,,,,,,,,,,,,,57101,ANO2,C12orf3|TMEM16B,,,,,,,,,,ANO2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300562,"[""Kv7.2/KCNQ2 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300449,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300562,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv7.2/KCNQ2 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001913,"[""colonic adenocarcinoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001914,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001913,,,,,,,BrendaTissueOBO,,BTO:0001913,,,,,,,,,,,,,,,,,,,colonic adenocarcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200282,"[""MAP3K19 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400186,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200282,,,,,,,,,,,,,,,,80122,MAP3K19,RCK|YSK4,,,,,,,,,,MAP3K19 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300456,"[""NR2B/GRIN2B subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300456,,,,,,,,,,,,,,,,,,,,,,,,,,,,NR2B/GRIN2B subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400441,"[""KCNMB/KCNMB4 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400358,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400441,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNMB/KCNMB4 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100269,"[""Serine/threonine-protein kinase lmtk1""]",,"A serine/threonine-protein kinase LMTK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6ZMQ8] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300183,,,,,,,,"A serine/threonine-protein kinase LMTK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6ZMQ8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100269,,,,https://pharos.nih.gov/idg/targets/Q6ZMQ8,,,,,,,,,,,,,AATK,AATYK|KIAA0641|LMR1|LMTK1,,Q6ZMQ8,,,,,,,,Serine/threonine-protein kinase lmtk1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400030,"[""Cholecystokinin receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400030,,,,,,,,,,,,,,,,,,,,,,,,,,,,Cholecystokinin receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10024,"[""migraine with aura""]",,A migraine characterized by migraine headache which is preceded or accompanied by a transient focal neurological phenomenon.,false,,,http://purl.obolibrary.org/obo/DOID_6364,,,,,,,,A migraine characterized by migraine headache which is preceded or accompanied by a transient focal neurological phenomenon.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10024,,,DOID:10025,NCI:C117005|ICD9CM:346.0|OMIM:609179|SNOMEDCT_US_2016_03_01:155047002|ICD10CM:G43.1|MESH:D020325|ICD10CM:G43.109|SNOMEDCT_US_2016_03_01:4473006|UMLS_CUI:C0154723|OMIM:609670,classic migraine,,disease_ontology,,DOID:10024,,,,,,,,,,,,,,,,,Xref MGI.,,migraine with aura,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10021,"[""duodenum cancer""]",,A small intestine cancer that is located_in the beginning section of the small intestine.,false,,,http://purl.obolibrary.org/obo/DOID_10154,,,,,,,,A small intestine cancer that is located_in the beginning section of the small intestine.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10021,,,DOID:6072,MESH:D004379|UMLS_CUI:C0541912|ICD10CM:C17.0|UMLS_CUI:C0153426|ICD9CM:152.0|SNOMEDCT_US_2016_03_01:363403002|SNOMEDCT_US_2016_03_01:254570009|SNOMEDCT_US_2016_03_01:154555009|NCI:C9328|NCI:C4803|SNOMEDCT_US_2016_03_01:269615000,cancer of duodenum|Duodenal cancer|duodenal neoplasm,,disease_ontology,,DOID:10021,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,duodenum cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10027,"[""tabes dorsalis""]",,"A tertiary neurosyphilis that results_in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has_symptom intense, stabbing pain in the back and legs that recurs irregularly, has_symptom gait ataxia, has_symptom hyperesthesia, has_symptom paresthesia, has_symptom loss of bladder sensation leading to urine retention, has_symptom erectile dysfunction.",false,,,http://purl.obolibrary.org/obo/DOID_9988,,,,,,,,"A tertiary neurosyphilis that results_in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has_symptom intense, stabbing pain in the back and legs that recurs irregularly, has_symptom gait ataxia, has_symptom hyperesthesia, has_symptom paresthesia, has_symptom loss of bladder sensation leading to urine retention, has_symptom erectile dysfunction.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10027,,,,SNOMEDCT_US_2016_03_01:51928006|SNOMEDCT_US_2016_03_01:266134000|NCI:C35057|SNOMEDCT_US_2016_03_01:315826004|MESH:D013606|SNOMEDCT_US_2016_03_01:2844004|SNOMEDCT_US_2016_03_01:266210001|UMLS_CUI:C0039223|ICD10CM:A52.11|SNOMEDCT_US_2016_03_01:154384001|ICD9CM:094.0|SNOMEDCT_US_2016_03_01:316841006|SNOMEDCT_US_2016_03_01:186885003,Tabes dorsalis - neurosyphilis|Posterior spinal sclerosis,,disease_ontology,,DOID:10027,http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease|http://purl.obolibrary.org/obo/doid#sexually_transmitted_infectious_disease,,,,,,,,,,,,,,,,,,tabes dorsalis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000270,"[""MET(Y1235D) kinase domain""]",,Hepatocyte growth factor receptor; AUTS9; c-Met; HGFR; MET; RCCP2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Hepatocyte growth factor receptor; AUTS9; c-Met; HGFR; MET; RCCP2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000270,,,,,,,,,,,,,,,,,,,200261,,,,,,,,,MET(Y1235D) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000338,"[""PI42C kinase domain""]",,Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma; FLJ22055; PIP4K2C; PIP5K2C,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma; FLJ22055; PIP4K2C; PIP5K2C,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000338,,,,,,,,,,,,,,,,,,,200343,,,,,,,,,PI42C kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000005,"[""ABL1(E255K)-phosphorylated kinase domain""]",,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",false,,,http://www.drugtargetontology.org/dto/DTO_61000004,,,,,,,,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000005,,,,,,,,,,,,,,,,,,,200004,,,,,,,,,ABL1(E255K)-phosphorylated kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001786,"[""pheromone gland""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000254,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001786,,,,,,,BrendaTissueOBO,,BTO:0001786,,,,,,,,,,,,,,,,,,,pheromone gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000095,"[""CSF1R-autoinhibited kinase domain""]",,Colony stimulating factor 1 receptor; CD115; C-FMS; CSF1R; CSF-1R; CSF-1-R; CSFR; FIM2; FIM-2; FMS; Fms/CSFR,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Colony stimulating factor 1 receptor; CD115; C-FMS; CSF1R; CSF-1R; CSF-1-R; CSFR; FIM2; FIM-2; FMS; Fms/CSFR,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000095,,,,,,,,,,,,,,,,,,,200471,,,,,,,,,CSF1R-autoinhibited kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002517,"[""follicular lymphoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001518,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002517,,,,,,,BrendaTissueOBO,,BTO:0002517,,,,,,,,,,,,,,,,,,,follicular lymphoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200216,"[""CAMK1D gene""]",,"This gene encodes a member of the Ca2+/calmodulin-dependent protein kinase 1 subfamily of serine/threonine kinases. The encoded protein may be involved in the regulation of granulocyte function through the chemokine signal transduction pathway. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400171,,,,,,,,"This gene encodes a member of the Ca2+/calmodulin-dependent protein kinase 1 subfamily of serine/threonine kinases. The encoded protein may be involved in the regulation of granulocyte function through the chemokine signal transduction pathway. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200216,,,,,,,,,,,,,,,,57118,CAMK1D,CAMKID,,,,,,,,,,CAMK1D gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100138,"[""Ephrin type-b receptor 6""]",,"ephrin type-b receptor 6 (EPHB6)  with  no mutation  in a nonphosphorylated state|An ephrin type-B receptor 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15197] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300153,,,,,,,,"ephrin type-b receptor 6 (EPHB6)  with  no mutation  in a nonphosphorylated state|An ephrin type-B receptor 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15197] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100138,,,,https://pharos.nih.gov/idg/targets/O15197,,,,,,,,,,,,,EPHB6,,,O15197,,,,,,,,Ephrin type-b receptor 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100089,"[""Cyclic nucleotide-gated cation channel beta-1""]",,"A cyclic nucleotide-gated cation channel beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14028] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300406,,,,,,,,"A cyclic nucleotide-gated cation channel beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14028] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100089,,,,https://pharos.nih.gov/idg/targets/Q14028,,,,,,,,,,,,,CNGB1,CNCG2|CNCG3L|CNCG4|RCNC2,,Q14028,,,,,,,,Cyclic nucleotide-gated cation channel beta-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100524,"[""Tgf-beta receptor type-2""]",,"TGF-beta receptor type-2 (TGFBR2)  with  no mutation  in a nonphosphorylated state|A TGF-beta receptor type-2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P37173] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300252,,,,,,,,"TGF-beta receptor type-2 (TGFBR2)  with  no mutation  in a nonphosphorylated state|A TGF-beta receptor type-2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P37173] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100524,,,,https://pharos.nih.gov/idg/targets/P37173,,,,,,,,,,,,,TGFBR2,,,P37173,,,,,,,,Tgf-beta receptor type-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217568,"[""NR3C2 gene""]",,"This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_00217474,,,,,,,,"This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217568,,,,,,,,,,,,,,,,4306,NR3C2,MCR|MLR,,,,,,,,,,NR3C2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2527,"[""nephrosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_557,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2527,,,,UMLS_CUI:C0027720|MESH:D009401|SNOMEDCT_US_2016_03_01:90708001,,,disease_ontology,,DOID:2527,,,,,,,,,,,,,,,,,,,nephrosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400378,"[""Acid-sensing ion channel 3 (ASIC3) subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400330,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400378,,,,,,,,,,,,,,,,,,,,,,,,,,,,Acid-sensing ion channel 3 (ASIC3) subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050460,"[""Wolf-Hirschhorn syndrome""]",,OMIM mapping confirmed by DO. [LS].,false,,,http://purl.obolibrary.org/obo/DOID_0060388,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050460,,,DOID:6684,NCI:C35528|UMLS_CUI:C1956097|ICD10CM:Q93.3|UMLS_CUI:C0796117|OMIM:194190|MESH:D054877|SNOMEDCT_US_2016_03_01:17122004,chromosome 4p16.3 deletion syndrome|PITT SYNDROME|Pitt-Rogers-Danks Syndrome|4p deletion syndrome,,disease_ontology,,DOID:0050460,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,Wolf-Hirschhorn syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050466,"[""Loeys-Dietz syndrome""]",,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050466,,,,OMIM:613795|OMIM:609192|ORDO:60030|NCI:C75006|OMIM:610168|OMIM:614816|UMLS_CUI:C1836635|SNOMEDCT_US_2016_03_01:446263001|UMLS_CUI:C2697932|MESH:D055947,,,disease_ontology,,DOID:0050466,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,Loeys-Dietz syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050462,"[""Antley-Bixler syndrome""]",,An autosomal recessive disease that is characterized at birth or prenatally by malformations and deformities affecting the majority of the skeleton and other areas of the body with autosomal recessive inheritance of the FGFR2 gene.,false,,,http://purl.obolibrary.org/obo/DOID_0050737,,,,,,,,An autosomal recessive disease that is characterized at birth or prenatally by malformations and deformities affecting the majority of the skeleton and other areas of the body with autosomal recessive inheritance of the FGFR2 gene.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050462,,,,UMLS_CUI:C2936791|UMLS_CUI:C2350233|MESH:D054882|UMLS_CUI:C1860042|OMIM:201750|SNOMEDCT_US_2016_03_01:62964007|OMIM:207410,trapezoidocephaly-synostosis syndrome,,disease_ontology,,DOID:0050462,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Antley-Bixler syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050469,"[""Costello syndrome""]",,"A syndrome characterized by craniofacial dysmorphology, cardiac defects, mild mental retardation, and high birth weight followed by a failure to thrive and developmental delays.",false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,"A syndrome characterized by craniofacial dysmorphology, cardiac defects, mild mental retardation, and high birth weight followed by a failure to thrive and developmental delays.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050469,,,,SNOMEDCT_US_2016_03_01:309776008|SNOMEDCT_US_2016_03_01:205803001|UMLS_CUI:C0587248|NCI:C84652|MESH:D056685|OMIM:218040,FCS SYNDROME|Faciocutaneoskeletal Syndrome,,disease_ontology,,DOID:0050469,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Costello syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200219,"[""GRM2 gene""]",,"A metabotropic glutamate receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14416] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400059,,,,,,,,"A metabotropic glutamate receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14416] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200219,,,,,,,,,,,,,,,,2912,GRM2,GPRC1B|MGLUR2,,,,,,,,,,GRM2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300105,"[""CAMK group""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300102,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300105,,,,,,,,,,,,,,,,,,,,,,,,,,,,CAMK group,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100647,"[""Olfactory receptor 5T3""]",,"An olfactory receptor 5T3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5T3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100647,,,,https://pharos.nih.gov/idg/targets/Q8NGG3,,,,,,,,,,,,,OR5T3,,,Q8NGG3,,,,,,,,Olfactory receptor 5T3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100567,"[""Olfactory receptor 4A8""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100567,,,,https://pharos.nih.gov/idg/targets/P0C604,,,,,,,,,,,,,OR4A8P,OR4A8,,P0C604,,,,,,,,Olfactory receptor 4A8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000208,"[""CCL24""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000208,,,,,,,,,,,,,,,,,,,,,,,,,,,,CCL24,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8443,"[""brachial plexus lesion""]",,"A brachial plexus neuropathy characterized by an abnormality, usually caused by disease or trauma, located in the brachial plexus.",false,,,http://purl.obolibrary.org/obo/DOID_3690,,,,,,,,"A brachial plexus neuropathy characterized by an abnormality, usually caused by disease or trauma, located in the brachial plexus.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8443,,,,UMLS_CUI:C0006091|ICD9CM:353.0|SNOMEDCT_US_2016_03_01:3548001|SNOMEDCT_US_2016_03_01:193109004,Brachial plexus lesions NOS (disorder)|Brachial plexus lesions,,disease_ontology,,DOID:8443,,,,,,,,,,,,,,,,,,,brachial plexus lesion,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000170,"[""FLT3(R834Q) kinase domain""]",,Fms-related tyrosine kinase 3; CD135; FLK2; FLK-2; FLT3; FLT-3; Ly72; STK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Fms-related tyrosine kinase 3; CD135; FLK2; FLK-2; FLT3; FLT-3; Ly72; STK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000170,,,,,,,,,,,,,,,,,,,200174,,,,,,,,,FLT3(R834Q) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100136,"[""Ephrin type-b receptor 3""]",,"ephrin type-b receptor 3 (EPHB3)  with  no mutation  in a nonphosphorylated state|An ephrin type-B receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54753] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300153,,,,,,,,"ephrin type-b receptor 3 (EPHB3)  with  no mutation  in a nonphosphorylated state|An ephrin type-B receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54753] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100136,,,,https://pharos.nih.gov/idg/targets/P54753,,,,,,,,,,,,,EPHB3,ETK2|HEK2|TYRO6,,P54753,,,,,,,,Ephrin type-b receptor 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100512,"[""Tgf-beta-activated kinase 1 and map3k7-binding protein 1""]",,A TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 that is encoded in the genome of human. [PRO:CNA] ,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,A TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 that is encoded in the genome of human. [PRO:CNA] ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100512,,,,https://pharos.nih.gov/idg/targets/Q15750,,,,,,,,,,,,,TAB1,MAP3K7IP1,,Q15750,,,,,,,,Tgf-beta-activated kinase 1 and map3k7-binding protein 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2722,"[""acrodermatitis""]",,A dermatitis that selectively affects the hands and feet.,false,,,http://purl.obolibrary.org/obo/DOID_2723,,,,,,,,A dermatitis that selectively affects the hands and feet.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2722,,,,MESH:D000169|UMLS_CUI:C0001197|CSP:4008-0032|NCI:C84532|SNOMEDCT_US_2016_03_01:8197001,,,disease_ontology,,DOID:2722,,,,,,,,,,,,,,,,,,,acrodermatitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000059,"[""BUB1 kinase domain""]",,Budding uninhibited by benzimidazoles 1 homolog (yeast); BUB1A; BUB1L; hBUB1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Budding uninhibited by benzimidazoles 1 homolog (yeast); BUB1A; BUB1L; hBUB1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000059,,,,,,,,,,,,,,,,,,,200470,,,,,,,,,BUB1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000264,"[""bone marrow cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000264,,,,,,,BrendaTissueOBO,,BTO:0000264,,,,,,,,,,,,,,,,,,,bone marrow cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3306,"[""mixed germ cell cancer""]",,A germ cell cancer that occurs in many forms.,false,,,http://purl.obolibrary.org/obo/DOID_2994,,,,,,,,A germ cell cancer that occurs in many forms.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3306,,,,UMLS_CUI:C0334524|SNOMEDCT_US_2016_03_01:32844007|SNOMEDCT_US_2016_03_01:189853002|NCI:C9010|NCI:C4290,mixed teratoma and seminoma|mixed teratoma and Seminoma|mixed germ cell neoplasm|mixed germ cell tumour,,disease_ontology,,DOID:3306,,,,,,,,,,,,,,,,,,,mixed germ cell cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3193,"[""peripheral nerve sheath neoplasm""]",,A peripheral nervous system neoplasm that is located_in the connective tissue surrounding nerves.,false,,,http://purl.obolibrary.org/obo/DOID_1192,,,,,,,,A peripheral nervous system neoplasm that is located_in the connective tissue surrounding nerves.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3193,,,,UMLS_CUI:C0751689|MESH:D018317,neoplasm of the nerve Sheath|nerve sheath tumour,,disease_ontology,,DOID:3193,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,peripheral nerve sheath neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100373,"[""Nt-3 growth factor receptor""]",,"NT-3 growth factor receptor (TRKC)  with  no mutation  in a nonphosphorylated state|An NT-3 growth factor receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16288] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300200,,,,,,,,"NT-3 growth factor receptor (TRKC)  with  no mutation  in a nonphosphorylated state|An NT-3 growth factor receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16288] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100373,,,,https://pharos.nih.gov/idg/targets/Q16288,,,,,,,,,,,,,NTRK3,TRKC,,Q16288,,,,,,,,Nt-3 growth factor receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100427,"[""Serine/threonine-protein kinase n1""]",,"A serine/threonine-protein kinase N1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16512] |serine/threonine-protein kinase n1 (PKN1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300210,,,,,,,,"A serine/threonine-protein kinase N1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16512] |serine/threonine-protein kinase n1 (PKN1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100427,,,,https://pharos.nih.gov/idg/targets/Q16512,,,,,,,,,,,,,PKN1,PAK1|PKN|PRK1|PRKCL1,,Q16512,,,,,,,,Serine/threonine-protein kinase n1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060456,"[""Schnyder corneal dystrophy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060442,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060456,elvira,2015-10-16T18:01:14Z,,SNOMEDCT_US_2016_03_01:39662004|SNOMEDCT_US_2016_03_01:419395007|MESH:C535475|ORDO:98967|SNOMEDCT_US_2016_03_01:420212002|OMIM:121800|UMLS_CUI:C0271287,corneal dystrophy crystalline of Schnyder|hereditary crystalline stromal dystrophy of Schnyder|SCCD|Schnyder crystalline corneal dystrophy|crystalline stromal dystrophy,,disease_ontology,,DOID:0060456,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,Schnyder corneal dystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060457,"[""posterior polymorphous corneal dystrophy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060443,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060457,elvira,2015-10-16T18:05:26Z,,OMIM:609141|ORDO:98973|MESH:C562745|ICD10CM:H18.5|OMIM:122000|OMIM:609140,PPCD|Schlichting dystrophy|hereditary polymorphus posterior corneal dystrophy,,disease_ontology,,DOID:0060457,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,posterior polymorphous corneal dystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000380,"[""RIOK1 kinase domain""]",,RIO kinase 1 (yeast); AD034; bA288G3.1; FLJ30006; MGC12903; RIOK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,RIO kinase 1 (yeast); AD034; bA288G3.1; FLJ30006; MGC12903; RIOK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000380,,,,,,,,,,,,,,,,,,,200374,,,,,,,,,RIOK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8498,"[""hereditary night blindness""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_8499,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8498,,,,SNOMEDCT_US_2016_03_01:193688005|MESH:C537743|SNOMEDCT_US_2016_03_01:193689002|SNOMEDCT_US_2016_03_01:193687000|ICD10CM:H53.63|UMLS_CUI:C1306122|SNOMEDCT_US_2016_03_01:89208008|ICD9CM:368.61,Oguchi's disease|Congenital night blindness,,disease_ontology,,DOID:8498,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,hereditary night blindness,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200304,"[""MARK3 gene""]",,"The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400290,,,,,,,,"The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200304,,,,,,,,,,,,,,,,4140,MARK3,CTAK1|EMK2,,,,,,,,,,MARK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200134,"[""GRIA2 gene""]",,"Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG-&gt;CGG; Q-&gt;R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400411,,,,,,,,"Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG-&gt;CGG; Q-&gt;R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200134,,,,,,,,,,,,,,,,2891,GRIA2,GLUR2,,,,,,,,,,GRIA2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200211,"[""KCNH7 gene""]",,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. There are at least two alternatively spliced transcript variants derived from this gene and encoding distinct isoforms. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400559,,,,,,,,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. There are at least two alternatively spliced transcript variants derived from this gene and encoding distinct isoforms. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200211,,,,,,,,,,,,,,,,90134,KCNH7,ERG3,,,,,,,,,,KCNH7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200102,"[""FXYD4 gene""]",,"This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. FXYD4, originally named CHIF for channel-inducing factor, has been shown to modulate the properties of the Na,K-ATPase, as has FXYD2, also known as the gamma subunit of the Na,K-ATPase, and FXYD7. Transmembrane topology has been established for FXYD4 and two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. Alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, May 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400348,,,,,,,,"This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. FXYD4, originally named CHIF for channel-inducing factor, has been shown to modulate the properties of the Na,K-ATPase, as has FXYD2, also known as the gamma subunit of the Na,K-ATPase, and FXYD7. Transmembrane topology has been established for FXYD4 and two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. Alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, May 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200102,,,,,,,,,,,,,,,,53828,FXYD4,,,,,,,,,,,FXYD4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200277,"[""NPBWR2 gene""]",,"A neuropeptides B/W receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48146] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400068,,,,,,,,"A neuropeptides B/W receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48146] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200277,,,,,,,,,,,,,,,,2832,NPBWR2,GPR8,,,,,,,,,,NPBWR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491007,"[""Mevalonate kinase subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491026,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491007,,,,,,,,,,,,,,,,,,,,,,,,,,,,Mevalonate kinase subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004800,"[""amnioserosa""]",,"The amnioserosa is an extraembryonic, epithelial tissue that covers the dorsal side of the Drosophila embryo.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000174,,,,,,,,"The amnioserosa is an extraembryonic, epithelial tissue that covers the dorsal side of the Drosophila embryo.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004800,mgr,2010-10-05T09:52:00Z,,,,,BrendaTissueOBO,amnion-serosa,BTO:0004800,,,,,,,,,,,,,,,,,,,amnioserosa,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300172,"[""CAMK2 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300172,,,,,,,,,,,,,,,,,,,,,,,,,,,,CAMK2 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100370,"[""Olfactory receptor 2t12""]",,"An olfactory receptor 2T12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG77] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2T12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG77] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100370,,,,https://pharos.nih.gov/idg/targets/Q8NG77,,,,,,,,,,,,,OR2T12,,,Q8NG77,,,,,,,,Olfactory receptor 2t12,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200071,"[""CNR2 gene""]",,"A cannabinoid receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P34972] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400035,,,,,,,,"A cannabinoid receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P34972] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200071,,,,,,,,,,,,,,,,1269,CNR2,CB2A|CB2B,,,,,,,,,,CNR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000041,"[""LEU1196 in ALK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000041,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU1196 in ALK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100045,"[""C3a anaphylatoxin chemotactic receptor""]",,"A C3a anaphylatoxin chemotactic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q16581] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300027,,,,,,,,"A C3a anaphylatoxin chemotactic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q16581] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100045,,,,https://pharos.nih.gov/idg/targets/Q16581,,,,,,,,,,,,,C3AR1,AZ3B|C3R1|HNFAG09,,Q16581,,,,,,,,C3a anaphylatoxin chemotactic receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005206,"[""middle cerebral artery""]",,The middle cerebral artery (MCA) is one of the three major paired arteries that supplies blood to the cerebrum.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0005205,,,,,,,,The middle cerebral artery (MCA) is one of the three major paired arteries that supplies blood to the cerebrum.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005206,XPMUser,2011-09-02T10:01:04Z,,,,,BrendaTissueOBO,,BTO:0005206,,,,,,,,,,,,,,,,,,,middle cerebral artery,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200303,"[""SCNN1A gene""]",,"Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400477,,,,,,,,"Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200303,,,,,,,,,,,,,,,,6337,SCNN1A,SCNN1,,,,,,,,,,SCNN1A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14256,"[""adult-onset Still's disease""]",,"An arthritis that is a rare from of inflammatory arthritis characterized by fevers, rash, and joint pain.",false,,,http://purl.obolibrary.org/obo/DOID_848,,,,,,,,"An arthritis that is a rare from of inflammatory arthritis characterized by fevers, rash, and joint pain.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14256,,,,SNOMEDCT_US_2016_03_01:239920006|SNOMEDCT_US_2016_03_01:201815006|UMLS_CUI:C0085253|MESH:D016706|SNOMEDCT_US_2016_03_01:201449008|ICD10CM:M06.1,adult-onset Still disease|adult onset Still's disease,,disease_ontology,,DOID:14256,,,,,,,,,,,,,,,,,,,adult-onset Still's disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14250,"[""Down syndrome""]",,A chromosomal disease that is characterized by flat-looking facial features and weak muscle tone (hypotonia) in infancy and is caused by trisomy of all or a critical portion of chromosome 21 and is associated with intellectual disability.,false,,,http://purl.obolibrary.org/obo/DOID_0080014,,,,,,,,A chromosomal disease that is characterized by flat-looking facial features and weak muscle tone (hypotonia) in infancy and is caused by trisomy of all or a critical portion of chromosome 21 and is associated with intellectual disability.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14250,,,,SNOMEDCT_US_2016_03_01:41040004|NCI:C101222|SNOMEDCT_US_2016_03_01:254263008|MESH:D004314|SNOMEDCT_US_2016_03_01:205618003|ICD10CM:Q90|SNOMEDCT_US_2016_03_01:157019002|ICD10CM:Q90.9|ICD9CM:758.0|UMLS_CUI:C0013080|OMIM:190685|NCI:C2993|SNOMEDCT_US_2016_03_01:205614001,Downs syndrome|Down's syndrome|trisomy 21 syndrome|Down's syndrome - trisomy 21|G Trisomy|Complete trisomy 21 syndrome (disorder),,disease_ontology,,DOID:14250,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Down syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200257,"[""GRIN2A gene""]",,"This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_01400455,,,,,,,,"This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200257,,,,,,,,,,,,,,,,2903,GRIN2A,NMDAR2A,,,,,,,,,,GRIN2A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100446,"[""Proto-oncogene tyrosine-protein kinase receptor ret""]",,"proto-oncogene tyrosine-protein kinase receptor ret (RET(V804M))  with  mutation M804 in RET(V804M) in a nonphosphorylated state|proto-oncogene tyrosine-protein kinase receptor ret (RET(M918T))  with  mutation T918 in RET(M918T) in a nonphosphorylated state|proto-oncogene tyrosine-protein kinase receptor ret (RET)  with  no mutation  in a nonphosphorylated state|A proto-oncogene tyrosine-protein kinase receptor Ret that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07949] |proto-oncogene tyrosine-protein kinase receptor ret (RET(V804L))  with  mutation L804 in RET(V804L) in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300216,,,,,,,,"proto-oncogene tyrosine-protein kinase receptor ret (RET(V804M))  with  mutation M804 in RET(V804M) in a nonphosphorylated state|proto-oncogene tyrosine-protein kinase receptor ret (RET(M918T))  with  mutation T918 in RET(M918T) in a nonphosphorylated state|proto-oncogene tyrosine-protein kinase receptor ret (RET)  with  no mutation  in a nonphosphorylated state|A proto-oncogene tyrosine-protein kinase receptor Ret that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07949] |proto-oncogene tyrosine-protein kinase receptor ret (RET(V804L))  with  mutation L804 in RET(V804L) in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100446,,,,https://pharos.nih.gov/idg/targets/P07949,,,,,,,,,,,,,RET,CDHF12|CDHR16|PTC|RET51,,P07949,,,,,,,,Proto-oncogene tyrosine-protein kinase receptor ret,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6195,"[""conjunctivitis""]",,"A conjunctival disease characterized by an inflammation of the conjunctiva, the outermost layer of the eye and the inner surface of the eyelids.",false,,,http://purl.obolibrary.org/obo/DOID_4251,,,,,,,,"A conjunctival disease characterized by an inflammation of the conjunctiva, the outermost layer of the eye and the inner surface of the eyelids.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6195,,,,SNOMEDCT_US_2016_03_01:193857008|MESH:D003231|ICD10CM:H10.9|SNOMEDCT_US_2016_03_01:193875009|SNOMEDCT_US_2016_03_01:193858003|NCI:C34504|SNOMEDCT_US_2016_03_01:9826008|ICD9CM:372.30|ICD10CM:H10|UMLS_CUI:C0009763,,,disease_ontology,Madras eye,DOID:6195,,,,,,,,,,,,,,,,,,,conjunctivitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_16761,"[""ADP""]","Adenosine-5-diphosphate|Adenosine pyrophosphate|ADENOSINE-5'-DIPHOSPHATE|Adenosine-5'-diphosphate|Adenosine 5'-pyrophosphate|adenosine 5'-(trihydrogen diphosphate)|Adenosine diphosphate|XTWYTFMLZFPYCI-KQYNXXCUSA-N|
Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
|
[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxyphosphonic acid
|Adenosindiphosphorsaeure|Adenosine 5'-diphosphate|H3adp|C10H15N5O10P2|
[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxyphosphonic acid
|5'-adenylphosphoric acid|
InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
|
[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid
|Adenosine-diphosphate","
A purine ribonucleoside 5'-diphosphate having adenine as the nucleobase.
",false,,,http://purl.obolibrary.org/obo/CHEBI_36976,,,,,,,KNApSAcK:C00019353|KEGG COMPOUND:C00008|ChemIDplus:58-64-0|Reaxys:67722|CiteXplore:15763887|CiteXplore:15882454|CiteXplore:1399831|CiteXplore:16371119|Beilstein:67722|CiteXplore:24023812|PDBeChem:ADP|CiteXplore:1515641|CiteXplore:15993662|CiteXplore:17010792|CiteXplore:16295522|KEGG GLYCAN:G11113|Wikipedia:ADP|COMe:MOL000173|CiteXplore:15886810|Gmelin:88452|HMDB:HMDB01341|CiteXplore:16307036|CiteXplore:15945611|CiteXplore:15869601|KEGG COMPOUND:58-64-0|CiteXplore:16761747|CiteXplore:8719843|DrugBank:DB03431|KEGG COMPOUND:20398-34-9|MetaCyc:ADP|CiteXplore:15654516,"
A purine ribonucleoside 5'-diphosphate having adenine as the nucleobase.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:13222|CHEBI:40553|CHEBI:22244|CHEBI:2342,,ADP|adenosine 5'-(trihydrogen diphosphate),,chebi_ontology,"Adenosine-5-diphosphate|Adenosine pyrophosphate|ADENOSINE-5'-DIPHOSPHATE|Adenosine-5'-diphosphate|Adenosine 5'-pyrophosphate|adenosine 5'-(trihydrogen diphosphate)|Adenosine diphosphate|XTWYTFMLZFPYCI-KQYNXXCUSA-N|
Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
|
[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxyphosphonic acid
|Adenosindiphosphorsaeure|Adenosine 5'-diphosphate|H3adp|C10H15N5O10P2|
[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxyphosphonic acid
|5'-adenylphosphoric acid|
InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
|
[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid
|Adenosine-diphosphate",,,CHEBI:16761,,,,,,,,,,,,,,,,,,,,,,,CHEBI:16761,,,,,ADP,,CHEBI:16761,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200014,"[""ADCK2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400248,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200014,,,,,,,,,,,,,,,,90956,ADCK2,AARF,,,,,,,,,,ADCK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001402,"[""urogenital ridge""]",,A pair of dorsolateral mesodermal ridges in the vertebrate embryo out of which the urogenital organs are developed.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A pair of dorsolateral mesodermal ridges in the vertebrate embryo out of which the urogenital organs are developed.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001402,,,,,,,BrendaTissueOBO,,BTO:0001402,,,,,,,,,,,,,,,,,,,urogenital ridge,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200806,"[""TAAR8 gene""]",,"A trace amine-associated receptor 8 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q969N4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A trace amine-associated receptor 8 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q969N4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200806,,,,,,,,,,,,,,,,83551,TAAR8,GPR102|TA5|TAR5|TRAR5,,,,,,,,,,TAAR8 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3070,"[""malignant glioma""]",,A cell type cancer that has_material_basis_in glial cells and is located_in brain or located_in spine.,false,,,http://purl.obolibrary.org/obo/DOID_0050687,,,,,,,,A cell type cancer that has_material_basis_in glial cells and is located_in brain or located_in spine.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3070,,,DOID:2627,SNOMEDCT_US_2016_03_01:189926000|OMIM:613033|SNOMEDCT_US_2016_03_01:189909006|UMLS_CUI:C0017638|UMLS_CUI:C0555198|OMIM:613029|NCI:C3059|KEGG:05214|SNOMEDCT_US_2016_03_01:74532006|SNOMEDCT_US_2016_03_01:115240006|OMIM:607248|OMIM:137800|OMIM:613032|OMIM:613030|OMIM:613028|SNOMEDCT_US_2016_03_01:269505000|SNOMEDCT_US_2016_03_01:393564001|MESH:D005910|NCI:C4822|OMIM:613031|SNOMEDCT_US_2016_03_01:189908003|SNOMEDCT_US_2016_03_01:416500007|ORDO:182067,"glioma, malignant, no ICD-O subtype|glioma NOS|glioma, malignant|Gliomas (morphologic abnormality)|malignant glioma - category|glioma, NOS|Neuroglial tumor|malignant glioma (morphologic abnormality)|glioma NOS (morphologic abnormality)|glioma|glioma (morphologic abnormality)|malignant Neuroglial tumor|glial cell tumor",,disease_ontology,,DOID:3070,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,malignant glioma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060040,"[""pervasive developmental disorder""]",,"A developmental disorder of mental health that refers to a group of five disorders characterized by impairments in socialization and communication, as well as restricted interests and repetitive behaviors.",false,,,http://purl.obolibrary.org/obo/DOID_0060037,,,,,,,,"A developmental disorder of mental health that refers to a group of five disorders characterized by impairments in socialization and communication, as well as restricted interests and repetitive behaviors.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060040,,,DOID:1208,UMLS_CUI:C0154451|ICD9CM:299.80,pervasive development disorder,,disease_ontology,,DOID:0060040,,,,,,,,,,,,,,,,,,,pervasive developmental disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060042,"[""atypical autism""]",,An autism spectrum disorder that involves some autistic symptoms occuring after age 3 with an abscence of all the traits necessary for a diagnosis of autism.,false,,,http://purl.obolibrary.org/obo/DOID_0060041,,,,,,,,An autism spectrum disorder that involves some autistic symptoms occuring after age 3 with an abscence of all the traits necessary for a diagnosis of autism.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060042,,,,,PDD NOS,,disease_ontology,,DOID:0060042,,,,,,,,,,,,,,,,,,,atypical autism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060049,"[""autoimmune disease of urogenital tract""]",,A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the urogenital tract.,false,,,http://purl.obolibrary.org/obo/DOID_417,,,,,,,,A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the urogenital tract.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060049,,,,,,,disease_ontology,,DOID:0060049,,,,,,,,,,,,,,,,,,,autoimmune disease of urogenital tract,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060045,"[""Munchausen by proxy""]",,"A factitious disorder that involves a care giver's deliberate exaggeration, fabrication, and/or induce physical, psychological, behavioral, and/or mental health problems in others.",false,,,http://purl.obolibrary.org/obo/DOID_1766,,,,,,,,"A factitious disorder that involves a care giver's deliberate exaggeration, fabrication, and/or induce physical, psychological, behavioral, and/or mental health problems in others.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060045,,,,,,,disease_ontology,,DOID:0060045,,,,,,,,,,,,,,,,,,,Munchausen by proxy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060041,"[""autism spectrum disorder""]",,"A pervasive developmental disorder that is a spectrum of psychological conditions. The disease has_symptom widespread abnormalities of social interactions and communication, has_symptom severely restricted interests and has_symptom highly repetitive behavior.",false,,,http://purl.obolibrary.org/obo/DOID_0060040,,,,,,,,"A pervasive developmental disorder that is a spectrum of psychological conditions. The disease has_symptom widespread abnormalities of social interactions and communication, has_symptom severely restricted interests and has_symptom highly repetitive behavior.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060041,,,,,,,disease_ontology,,DOID:0060041,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,autism spectrum disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060046,"[""aphasia""]",,A language disorder that involves an acquired impairment of any laguage modality such as producting or comprehending spoken or written language.,false,,,http://purl.obolibrary.org/obo/DOID_93,,,,,,,,A language disorder that involves an acquired impairment of any laguage modality such as producting or comprehending spoken or written language.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060046,,,,,,,disease_ontology,,DOID:0060046,,,,,,,,,,,,,,,,,,,aphasia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060043,"[""sexual disorder""]",,A disease of mental health that involves the impairment in normal sexual functioning.,false,,,http://purl.obolibrary.org/obo/DOID_150,,,,,,,,A disease of mental health that involves the impairment in normal sexual functioning.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060043,,,,,,,disease_ontology,,DOID:0060043,,,,,,,,,,,,,,,,,,,sexual disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060047,"[""writing disorder""]",,"A learning disability that involves impaired written language ability such as impairments in handwriting, spelling, organization of ideas, and composition.",false,,,http://purl.obolibrary.org/obo/DOID_8927,,,,,,,,"A learning disability that involves impaired written language ability such as impairments in handwriting, spelling, organization of ideas, and composition.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060047,,,,,,,disease_ontology,,DOID:0060047,,,,,,,,,,,,,,,,,,,writing disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300366,"[""Mechanical nociceptor, piezo (piezo) family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300366,,,,,,,,,,,,,,,,,,,,,,,,,,,,"Mechanical nociceptor, piezo (piezo) family",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100337,"[""Dual specificity mitogen-activated protein kinase kinase 4""]",,"dual specificity mitogen-activated protein kinase kinase 4 (MP2K4)  with  no mutation  in a nonphosphorylated state|A dual specificity mitogen-activated protein kinase kinase 4 that is encoded in the genome of human. [TLR:AMM, UniProtKB:P45985] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300194,,,,,,,,"dual specificity mitogen-activated protein kinase kinase 4 (MP2K4)  with  no mutation  in a nonphosphorylated state|A dual specificity mitogen-activated protein kinase kinase 4 that is encoded in the genome of human. [TLR:AMM, UniProtKB:P45985] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100337,,,,https://pharos.nih.gov/idg/targets/P45985,,,,,,,,,,,,,MAP2K4,JNKK1|MEK4|MKK4|PRKMK4|SEK1|SERK1|SKK1,,P45985,,,,,,,,Dual specificity mitogen-activated protein kinase kinase 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200021,"[""CHRM1 gene""]",,"A muscarinic acetylcholine receptor M1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P11229] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400020,,,,,,,,"A muscarinic acetylcholine receptor M1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P11229] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200021,,,,,,,,,,,,,,,,1128,CHRM1,,,,,,,,,,,CHRM1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200441,"[""TP53RK gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400213,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200441,,,,,,,,,,,,,,,,112858,TP53RK,C20orf64|PRPK,,,,,,,,,,TP53RK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000357,"[""PIM3 kinase domain""]",,Pim-3 oncogene; PIM3; pim-3,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Pim-3 oncogene; PIM3; pim-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000357,,,,,,,,,,,,,,,,,,,200339,,,,,,,,,PIM3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200181,"[""KCNA2 gene""]",,"Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400533,,,,,,,,"Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200181,,,,,,,,,,,,,,,,3737,KCNA2,,,,,,,,,,,KCNA2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100393,"[""Olfactory receptor 51e2""]",,"An olfactory receptor 51E2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H255] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 51E2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H255] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100393,,,,https://pharos.nih.gov/idg/targets/Q9H255,,,,,,,,,,,,,OR51E2,PSGR,,Q9H255,,,,,,,,Olfactory receptor 51e2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200059,"[""CACNG5 gene""]",,"The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. This gene is a susceptibility locus for schizophrenia and bipolar disorder. [provided by RefSeq, Dec 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400336,,,,,,,,"The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. This gene is a susceptibility locus for schizophrenia and bipolar disorder. [provided by RefSeq, Dec 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200059,,,,,,,,,,,,,,,,27091,CACNG5,,,,,,,,,,,CACNG5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2843,"[""long QT syndrome""]",,"An autosomal genetic disease that is characterized by delayed repolarization of the heart following a heartbeat increases the risk of episodes of torsade de pointes (TDP, a form of irregular heartbeat that originates from the ventricles).",false,,,http://purl.obolibrary.org/obo/DOID_0060036,,,,,,,,"An autosomal genetic disease that is characterized by delayed repolarization of the heart following a heartbeat increases the risk of episodes of torsade de pointes (TDP, a form of irregular heartbeat that originates from the ventricles).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2843,,,DOID:4069,ICD9CM:426.82|ICD10CM:I45.81|UMLS_CUI:C0023976|SNOMEDCT_US_2016_03_01:9651007|MESH:D008133|NCI:C85049|NCI:C34786|MESH:D029597|UMLS_CUI:C0035828|SNOMEDCT_US_2016_03_01:20852007|SNOMEDCT_US_2016_03_01:395649008,long Q-T syndrome|LQT|Romano-Ward syndrome (disorder)|Romano-Ward syndrome,,disease_ontology,,DOID:2843,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,long QT syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5502,"[""lice infestation""]",,"A parasitic ectoparasitic infectious disease that involves infestation of lice, which are blood-feeding ectoparasitic insects of the order Phthiraptera.",false,,,http://purl.obolibrary.org/obo/DOID_4110,,,,,,,,"A parasitic ectoparasitic infectious disease that involves infestation of lice, which are blood-feeding ectoparasitic insects of the order Phthiraptera.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5502,,,DOID:5490|DOID:5523,MESH:D010373|SNOMEDCT_US_2016_03_01:414618002|ICD10CM:B85.2|SNOMEDCT_US_2016_03_01:20848007|SNOMEDCT_US_2016_03_01:266223008|SNOMEDCT_US_2016_03_01:187212006|SNOMEDCT_US_2016_03_01:154417001|SNOMEDCT_US_2016_03_01:187545007|SNOMEDCT_US_2016_03_01:187207005|UMLS_CUI:C0030756|SNOMEDCT_US_2016_03_01:74949007|ICD9CM:132.9,"mixed pediculosis infestation|Infestation by Pediculus (disorder)|Louse infestation (& [pediculosis and phthirus] or [lice])|Lice infestation, NOS|Pediculosis, unspecified (disorder)|mixed pediculosis (disorder)|Pediculosis and phthirus infestation|Pediculosis, unspecified|Pediculosis + lice NOS|mixed pediculosis|Louse infestation (disorder)|pediculosis|Pediculosis and phthirus infections (disorder)|pediculosis and phthirus infection|Pediculosis and phthirus infection NOS (disorder)",,disease_ontology,,DOID:5502,,,,,,,,,,,,,,,,,,,lice infestation,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5032,"[""pineal gland cancer""]",,An endocrine gland located_in the pineal gland located in the brain.,false,,,http://purl.obolibrary.org/obo/DOID_170,,,,,,,,An endocrine gland located_in the pineal gland located in the brain.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5032,,,DOID:4859|DOID:1662,SNOMEDCT_US_2016_03_01:363483004|SNOMEDCT_US_2016_03_01:93962006|ICD9CM:194.4|UMLS_CUI:C0031941|SNOMEDCT_US_2016_03_01:127026004|UMLS_CUI:C1412004|NCI:C3573|MESH:D010871|ICD10CM:C75.3|UMLS_CUI:C0153655|NCI:C3328|NCI:C6965|SNOMEDCT_US_2016_03_01:359619007|SNOMEDCT_US_2016_03_01:47598005,tumor of the pineal region|pineal body neoplasm|Pineocytic tumor|Pinealoma|neoplasm of pineal gland|neoplasm of the Pineal Region|malignant tumor of pineal gland|malignant Pineal Region tumor,,disease_ontology,,DOID:5032,,,,,,,,,,,,,,,,,,,pineal gland cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4449,"[""macular retinal edema""]",,,false,,,http://purl.obolibrary.org/obo/DOID_6929,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4449,,,,MESH:D008269|SNOMEDCT_US_2016_03_01:37231002|UMLS_CUI:C0271051|NCI:C35468,macular edema,,disease_ontology,,DOID:4449,,,,,,,,,,,,,,,,,,,macular retinal edema,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200293,"[""OR10A7 gene""]",,"An olfactory receptor 10A7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10A7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200293,,,,,,,,,,,,,,,,121364,OR10A7,,,,,,,,,,,OR10A7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005151,"[""anterior horn""]",,One of the hornlike projections of gray matter into the white matter of the spinal cord. The anterior horn contains efferent fibers innervating skeletal muscle tissue.,false,,,http://purl.obolibrary.org/obo/BTO_0000823|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,One of the hornlike projections of gray matter into the white matter of the spinal cord. The anterior horn contains efferent fibers innervating skeletal muscle tissue.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005151,XPMUser,2011-08-27T02:55:27Z,,,,,BrendaTissueOBO,ventral column|anterior column|ventral horn,BTO:0005151,,,,,,,,,,,,,,,,,,,anterior horn,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000231,"[""5-oxo-12-HETE""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000231,,,,,,,,,,,,,,,,,,,,,,,,,,,,5-oxo-12-HETE,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11971,"[""synostosis""]",,A dysostosis that results_in abnormal fusing of adjacent bones.,false,,,http://purl.obolibrary.org/obo/DOID_1934,,,,,,,,A dysostosis that results_in abnormal fusing of adjacent bones.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11971,,,,MESH:D013580|UMLS_CUI:C0039093,,,disease_ontology,,DOID:11971,,,,,,,,,,,,,,,,,,,synostosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000414,"[""epithelial cell""]",,Cell that cover the surface of the body and line its cavities.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Cell that cover the surface of the body and line its cavities.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000414,,,,,,,BrendaTissueOBO,,BTO:0000414,,,,,,,,,,,,,,,,,,,epithelial cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/UBERON_0000160,"[""intestine""]",bowel,"Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,http://en.wikipedia.org/wiki/Intestine|http://www.snomedbrowser.com/Codes/Details/256876008|http://linkedlifedata.com/resource/umls/id/C0021853|MA:0001524|BTO:0000648|VHOG:0000056|AAO:0000246|MESH:A03.492.411|EFO:0000834|EV:0100071|WBbt:0005772|EMAPA:32874|FMA:7199|ncithesaurus:Intestine|XAO:0000129|UMLS:C0021853|MIAA:0000043|ZFA:0001338|GAID:295|MA:0000328|galen:Intestine|BSA:0000093|TAO:0001338|CALOHA:TS-0490|ANISEED:1235303,"Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine.",,,,,,,,,,"The tract of the alimentary canal. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]|Portion of the alimentary canal bounded anteriorly by the pyloric sphincter and posteriorly by the cloacal sphincter.[AAO]",,,,,,,,,,,,,,,,,,,,,,,,,,bowel,,uberon,,intestinal,,,,,,,,,,,,,,,,,,,,,,,,,UBERON:0000160,,,"Editor notes: This class is probably too inclusive. Taxon notes: [in zebrafish] No stomach, small intestine, or large intestine can be distinguished. However, differences can be found in the morphology of the mucosa columnar epithelial cells and the number of goblet cells, suggesting functional differentiation. The intestine has numerous folds that become progressively shorter in a rostral-to-caudal direction. Proportionally, these folds are significantly larger than the finger-like intestinal villi of mammals and other amniotes (Wallace et al. 2005). Columnar-shaped absorptive enterocytes are the most numerous in the zebrafish intestinal epithelium. Goblet cells are the second most populous epithelial cell type.",,intestine,,UBERON:0000160,,http://purl.obolibrary.org/obo/uberon.owl,http://purl.obolibrary.org/obo/uberon/core#efo_slim|http://purl.obolibrary.org/obo/uberon/core#vertebrate_core|http://purl.obolibrary.org/obo/uberon/core#uberon_slim,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9726,"[""vitreous detachment""]",,,false,,,http://purl.obolibrary.org/obo/DOID_9720,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9726,,,,UMLS_CUI:C0042907|ICD10CM:H43.81|MESH:D020255|SNOMEDCT_US_2016_03_01:155202007|SNOMEDCT_US_2016_03_01:53772007|NCI:C50807|SNOMEDCT_US_2016_03_01:267747007|SNOMEDCT_US_2016_03_01:393583008,,,disease_ontology,,DOID:9726,,,,,,,,,,,,,,,,,,,vitreous detachment,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200153,"[""GPR150 gene""]",,"A G-protein coupled receptor 150 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8NGU9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 150 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8NGU9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200153,,,,,,,,,,,,,,,,285601,GPR150,,,,,,,,,,,GPR150 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000127,"[""EGFR(L858R) kinase domain""]",,"Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000127,,,,,,,,,,,,,,,,,,,200129,,,,,,,,,EGFR(L858R) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200561,"[""FLT4 gene""]",,"This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400242,,,,,,,,"This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200561,,,,,,,,,,,,,,,,2324,FLT4,VEGFR3,,,,,,,,,,FLT4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200080,"[""CDKL5 gene""]",,"This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400138,,,,,,,,"This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200080,,,,,,,,,,,,,,,,6792,CDKL5,STK9,,,,,,,,,,CDKL5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1712,"[""aortic valve stenosis""]",,An aortic valve disease that has_physical_basis_in incomplete opening of the aortic valve.,false,,,http://purl.obolibrary.org/obo/DOID_62,,,,,,,,An aortic valve disease that has_physical_basis_in incomplete opening of the aortic valve.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1712,,,DOID:1711|DOID:12034,SNOMEDCT_US_2016_03_01:18546004|SNOMEDCT_US_2016_03_01:390722003|ICD9CM:395.0|ICD9CM:746.3|ICD10CM:Q23.0|NCI:C50462|UMLS_CUI:C0003507|UMLS_CUI:C0155567|UMLS_CUI:C0152417|SNOMEDCT_US_2016_03_01:156922005|SNOMEDCT_US_2016_03_01:155282009|SNOMEDCT_US_2016_03_01:72011007|ICD10CM:I06.0|OMIM:109730|SNOMEDCT_US_2016_03_01:60573004|OMIM:614823|MESH:D001024|ORDO:402075,Congenital aortic valve stenosis|Aortic stenosis|rheumatic aortic valve stenosis|AS|Rheumatic aortic stenosis,,disease_ontology,,DOID:1712,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,aortic valve stenosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8446,"[""intussusception""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_8437,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8446,,,,OMIM:147710|MESH:D007443|NCI:C113484|ICD9CM:560.0|SNOMEDCT_US_2016_03_01:197055000|UMLS_CUI:C0021933|ICD10CM:K56.1|SNOMEDCT_US_2016_03_01:155772009|SNOMEDCT_US_2016_03_01:35327006|SNOMEDCT_US_2016_03_01:49723003,Invagination of intestine or colon|Intussusception of intestine (disorder)|Intussusception NOS (disorder)|Intussusception (morphologic abnormality),,disease_ontology,,DOID:8446,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,intussusception,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300327,"[""Ion channel""]",,"Ion channels are pore-forming membrane proteins whose functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane, controlling the flow of ions across secretory and epithelial cells, and regulating cell volume. Ion channels are present in the membranes of all cells.",false,,,http://purl.obolibrary.org/obo/PR_000000001,,,,,,,,"Ion channels are pore-forming membrane proteins whose functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane, controlling the flow of ions across secretory and epithelial cells, and regulating cell volume. Ion channels are present in the membranes of all cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,https://en.wikipedia.org/wiki/Ion_channel,Ion channel,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200629,"[""OR5J2 gene""]",,"An olfactory receptor 5J2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH18] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5J2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH18] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200629,,,,,,,,,,,,,,,,282775,OR5J2,,,,,,,,,,,OR5J2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200320,"[""OR10Q1 gene""]",,"An olfactory receptor 10Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200320,,,,,,,,,,,,,,,,219960,OR10Q1,,,,,,,,,,,OR10Q1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100785,"[""Taste receptor type 2 member 39""]",,"A taste receptor type 2 member 39 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59534] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300014,,,,,,,,"A taste receptor type 2 member 39 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59534] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100785,,,,https://pharos.nih.gov/idg/targets/P59534,,,,,,,,,,,,,TAS2R39,,,P59534,,,,,,,,Taste receptor type 2 member 39,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000186,"[""HIPK3 kinase domain""]",,Homeodomain interacting protein kinase 3; DYRK6; FIST3; HIPK3; PKY; YAK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Homeodomain interacting protein kinase 3; DYRK6; FIST3; HIPK3; PKY; YAK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000186,,,,,,,,,,,,,,,,,,,200188,,,,,,,,,HIPK3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200122,"[""GLP1R gene""]",,"A glucagon-like peptide 1 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P43220] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400047,,,,,,,,"A glucagon-like peptide 1 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P43220] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200122,,,,,,,,,,,,,,,,2740,GLP1R,,,,,,,,,,,GLP1R gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200177,"[""KCNMB2 gene""]",,"MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [provided by RefSeq, Jul 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_01400439,,,,,,,,"MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [provided by RefSeq, Jul 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200177,,,,,,,,,,,,,,,,10242,KCNMB2,,,,,,,,,,,KCNMB2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200597,"[""AK6 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200597,,,,,,,,,,,,,,,,,,,,,,,,,,,,AK6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100145,"[""Probable G-protein coupled receptor 139""]",,"A G-protein coupled receptor 139 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q6DWJ6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 139 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q6DWJ6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100145,,,,https://pharos.nih.gov/idg/targets/Q6DWJ6,,,,,,,,,,,,,GPR139,GPRG1|PGR3,,Q6DWJ6,,,,,,,,Probable G-protein coupled receptor 139,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400047,"[""Glucagon receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400003,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400047,,,,,,,,,,,,,,,,,,,,,,,,,,,,Glucagon receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8986,"[""narcolepsy""]",,"A sleep disorder that involves an excessive urge to sleep at inappropriate times, such as while at work.",false,,,http://purl.obolibrary.org/obo/DOID_535,,,,,,,,"A sleep disorder that involves an excessive urge to sleep at inappropriate times, such as while at work.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8986,,,DOID:8985,UMLS_CUI:C0027404|SNOMEDCT_US_2016_03_01:267702006|ICD10CM:G47.41|OMIM:605841|OMIM:612851|MESH:D009290|ORDO:2073|SNOMEDCT_US_2016_03_01:60380001|ICD9CM:347.0|OMIM:612417|ICD10CM:G47.419|EFO:0000614|NCI:C84489|OMIM:609039|OMIM:614223|SNOMEDCT_US_2016_03_01:155059003|OMIM:614250|OMIM:161400,"Narcolepsy, without cataplexy|paroxysmal sleep",,disease_ontology,,DOID:8986,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,narcolepsy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9649,"[""congenital nystagmus""]",,"A pathologic nystagmus, present at birth, characterized by involuntary, rhythmic eye movements; oscillations are usually horizontal in direction.",false,,,http://purl.obolibrary.org/obo/DOID_9650,,,,,,,,"A pathologic nystagmus, present at birth, characterized by involuntary, rhythmic eye movements; oscillations are usually horizontal in direction.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9649,,,,OMIM:614826|OMIM:300589|MESH:D020417|ICD9CM:379.51|OMIM:193003|OMIM:164100|SNOMEDCT_US_2016_03_01:64635004|ICD10CM:H55.01|ORDO:651|OMIM:608345|OMIM:300814|SNOMEDCT_US_2016_03_01:194173005|SNOMEDCT_US_2016_03_01:267750005|SNOMEDCT_US_2016_03_01:155205009|UMLS_CUI:C0700501,,,disease_ontology,,DOID:9649,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,congenital nystagmus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000024,"[""ABL1(Y253F)-phosphorylated kinase domain""]",,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",false,,,http://www.drugtargetontology.org/dto/DTO_61000023,,,,,,,,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000024,,,,,,,,,,,,,,,,,,,200023,,,,,,,,,ABL1(Y253F)-phosphorylated kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000829,"[""marrow""]",,1: A soft highly vascular modified connective tissue that occupies the cavities and cancellous part of most bones. 2: The substance of the spinal cord.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000421,,,,,,,,1: A soft highly vascular modified connective tissue that occupies the cavities and cancellous part of most bones. 2: The substance of the spinal cord.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000829,,,,,,,BrendaTissueOBO,,BTO:0000829,,,,,,,,,,,,,,,,,,,marrow,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2615,"[""papilloma""]",,A cell type benign neoplam that is composed_of epithelial tissue on papillae of vascularized connective tissue.,false,,,http://purl.obolibrary.org/obo/DOID_0060084,,,,,,,,A cell type benign neoplam that is composed_of epithelial tissue on papillae of vascularized connective tissue.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2615,,,DOID:1635,SNOMEDCT_US_2016_03_01:23730008|SNOMEDCT_US_2016_03_01:82049002|MESH:D010212|UMLS_CUI:C0205875|NCI:C7440|UMLS_CUI:C0030354|SNOMEDCT_US_2016_03_01:189564006|SNOMEDCT_US_2016_03_01:711329002|NCI:C3713,"papilloma (except papilloma of bladder M-81201) (morphologic abnormality)|papillomatosis, NOS|papillomatosis|papillomatosis NOS (morphologic abnormality)",,disease_ontology,,DOID:2615,,,,,,,,,,,,,,,,,,,papilloma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0090070,"[""hypogonadotropic hypogonadism""]",,A hypogonadism characterized by a impaired signalling by gonadotrpin relasing hormone.,false,,,http://purl.obolibrary.org/obo/DOID_1924,,,,,,,,A hypogonadism characterized by a impaired signalling by gonadotrpin relasing hormone.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0090070,,,,ICD10CM:E23.0|ORDO:478|OMIM:PS147950|ORDO:432,congenital idiopathic hypogonadotropic hypogonadism|isolated congenital gonadotropin deficiency,,doid,,DOID:0090070,,,,,,,,,,,,,,,,,,,hypogonadotropic hypogonadism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100622,"[""Olfactory receptor 5d18""]",,"An olfactory receptor 5D18 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5D18 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100622,,,,https://pharos.nih.gov/idg/targets/Q8NGL1,,,,,,,,,,,,,OR5D18,,,Q8NGL1,,,,,,,,Olfactory receptor 5d18,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4230,"[""smooth muscle cancer""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4045|http://purl.obolibrary.org/obo/DOID_66,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4230,,,,UMLS_CUI:C1334620|NCI:C6511,malignant tumor of Smooth Muscle,,disease_ontology,,DOID:4230,,,,,,,,,,,,,,,,,,,smooth muscle cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300304,"[""PAKB subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300187,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300304,,,,,,,,,,,,,,,,,,,,,,,,,,,,PAKB subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9253,"[""gastrointestinal stromal tumor""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_3119,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9253,,,,NCI:C3868|OMIM:606764|SNOMEDCT_US_2016_03_01:420120006|SNOMEDCT_US_2016_03_01:128755003|MESH:D046152|UMLS_CUI:C0238198,GIST|GANT|Stromal tumor of gastrointestinal tract,,disease_ontology,,DOID:9253,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,gastrointestinal stromal tumor,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100098,"[""Death-associated protein kinase 1""]",,"A death-associated protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P53355] |death-associated protein kinase 1 (DAPK1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300146,,,,,,,,"A death-associated protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P53355] |death-associated protein kinase 1 (DAPK1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100098,,,,https://pharos.nih.gov/idg/targets/P53355,,,,,,,,,,,,,DAPK1,DAPK,,P53355,,,,,,,,Death-associated protein kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100576,"[""Galactokinase""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100576,,,,,,,,,,,,,,,,,GALK1,,,P51570,,,,,,,,Galactokinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100443,"[""Inactive tyrosine-protein kinase 7""]",,"An inactive tyrosine-protein kinase 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13308] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300214,,,,,,,,"An inactive tyrosine-protein kinase 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13308] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100443,,,,https://pharos.nih.gov/idg/targets/Q13308,,,,,,,,,,,,,PTK7,CCK4,,Q13308,,,,,,,,Inactive tyrosine-protein kinase 7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200160,"[""KCNJ4 gene""]",,"Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400431,,,,,,,,"Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200160,,,,,,,,,,,,,,,,3761,KCNJ4,IRK3,,,,,,,,,,KCNJ4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000453,"[""ULK2 kinase domain""]",,Serine/threonine-protein kinase ULK2; Unc-51-like kinase 2 (C. elegans); KIAA0623; ULK2; Unc51.2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase ULK2; Unc-51-like kinase 2 (C. elegans); KIAA0623; ULK2; Unc51.2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000453,,,,,,,,,,,,,,,,,,,200456,,,,,,,,,ULK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2978,"[""carbohydrate metabolic disorder""]",,An inherited metabolic disorder that affect the catabolism and anabolism of carbohydrates.,false,,,http://purl.obolibrary.org/obo/DOID_655,,,,,,,,An inherited metabolic disorder that affect the catabolism and anabolism of carbohydrates.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2978,,,DOID:9434,UMLS_CUI:C0029777|UMLS_CUI:C0007001|MESH:D002239|ICD9CM:271.8,disorder of carbohydrate transport and metabolism|inborn errors of carbohydrate metabolism|inborn carbohydrate metabolism disorder,,disease_ontology,,DOID:2978,,,,,,,,,,,,,,,,,,,carbohydrate metabolic disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4830,"[""adenosquamous carcinoma""]",,A squamous cell carcinoma that contains squamous cells and gland-like cells.,false,,,http://purl.obolibrary.org/obo/DOID_1749,,,,,,,,A squamous cell carcinoma that contains squamous cells and gland-like cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4830,,,,SNOMEDCT_US_2016_03_01:403902008|SNOMEDCT_US_2016_03_01:59367005|MESH:D018196|NCI:C3727|UMLS_CUI:C0206623,Adenosquamous cell carcinoma (disorder)|Adenosquamous carcinoma (morphologic abnormality)|mixed adenocarcinoma and squamous carcinoma,,disease_ontology,,DOID:4830,,,,,,,,,,,,,,,,,,,adenosquamous carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200077,"[""CDKL2 gene""]",,"This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400138,,,,,,,,"This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200077,,,,,,,,,,,,,,,,8999,CDKL2,,,,,,,,,,,CDKL2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200107,"[""DGKA gene""]",,"The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03491025,,,,,,,,"The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200107,,,,,,,,,,,,,,,,1606,DGKA,DAGK|DAGK1,,,,,,,,,,DGKA gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8454,"[""ariboflavinosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5113,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8454,,,,SNOMEDCT_US_2016_03_01:20307000|SNOMEDCT_US_2016_03_01:267492001|ICD9CM:266.0|MESH:D012257|SNOMEDCT_US_2016_03_01:154726004|ICD10CM:E53.0|UMLS_CUI:C0035528,vitamin B2 deficiency,,disease_ontology,,DOID:8454,,,,,,,,,,,,,,,,,,,ariboflavinosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200379,"[""PIK3C2B gene""]",,"The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03491009,,,,,,,,"The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200379,,,,,,,,,,,,,,,,5287,PIK3C2B,,,,,,,,,,,PIK3C2B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300463,"[""Nav1.1/SCN1A subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300369,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300463,,,,,,,,,,,,,,,,,,,,,,,,,,,,Nav1.1/SCN1A subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_24870,"[""Ion""]",iones|ions|.|Ionen,A molecular entity having a net electric charge.,false,,,http://purl.obolibrary.org/obo/CHEBI_23367,,,,,,,,A molecular entity having a net electric charge.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,ion|Ion,,chebi_ontology,iones|ions|.|Ionen,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:24870,,,,,ion|Ion,,CHEBI:24870,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100196,"[""Tyrosine-protein kinase jak1""]",,"A tyrosine-protein kinase JAK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23458] |tyrosine-protein kinase jak1 (JAK1(Kin.Dom.1))  with  no mutation  in a nonphosphorylated state|tyrosine-protein kinase jak1 (JAK1(Kin.Dom.2))  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300167,,,,,,,,"A tyrosine-protein kinase JAK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23458] |tyrosine-protein kinase jak1 (JAK1(Kin.Dom.1))  with  no mutation  in a nonphosphorylated state|tyrosine-protein kinase jak1 (JAK1(Kin.Dom.2))  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100196,,,,https://pharos.nih.gov/idg/targets/P23458,,,,,,,,,,,,,JAK1,JAK1A|JAK1B,,P23458,,,,,,,,Tyrosine-protein kinase jak1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000010,"[""ABL1(F317L)-nonphosphorylated kinase domain""]",,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",false,,,http://www.drugtargetontology.org/dto/DTO_61000009,,,,,,,,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000010,,,,,,,,,,,,,,,,,,,"200008, 200009",,,,,,,,,ABL1(F317L)-nonphosphorylated kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117490,"[""Nuclear receptor ror-alpha""]",,"A nuclear receptor ROR-alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35398] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117464,,,,,,,,"A nuclear receptor ROR-alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35398] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117490,,,,https://pharos.nih.gov/idg/targets/P35398,,,,,,,,,,,,,RORA,RZRA,,P35398,,,,,,,,Nuclear receptor ror-alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400196,"[""MLCK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400196,,,,,,,,,,,,,,,,,,,,,,,,,,,,MLCK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001092,"[""KATO-III cell""]",,"Human stomach carcinoma cell line, established from a 55 years old mongoloid male.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000787,,,,,,,,"Human stomach carcinoma cell line, established from a 55 years old mongoloid male.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001092,,,,,,,BrendaTissueOBO,KATO III cell,BTO:0001092,,,,,,,,,,,,,,,,,,,KATO-III cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1532,"[""pleural disease""]",,"A thoracic disease which may involve inflammation of pleura, collection of air within the pleural cavity, abnormal collection of pleural fluid, abnormal growths on the pleura (pleural tumor) and pleural plaques. The main causes of pleural diseases including pleural effusions are congestive heart failure, malignancy, parapneumonic infections and pulmonary embolism.",false,,,http://purl.obolibrary.org/obo/DOID_0050161,,,,,,,,"A thoracic disease which may involve inflammation of pleura, collection of air within the pleural cavity, abnormal collection of pleural fluid, abnormal growths on the pleura (pleural tumor) and pleural plaques. The main causes of pleural diseases including pleural effusions are congestive heart failure, malignancy, parapneumonic infections and pulmonary embolism.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1532,,,DOID:1531,SNOMEDCT_US_2016_03_01:88075009|MESH:D010995|NCI:C26859|UMLS_CUI:C0032226,disorder of pleura|non-neoplastic pleural disease,,disease_ontology,,DOID:1532,,,,,,,,,,,,,,,,,,,pleural disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200212,"[""KCNH8 gene""]",,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400560,,,,,,,,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200212,,,,,,,,,,,,,,,,131096,KCNH8,,,,,,,,,,,KCNH8 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003667,"[""inner hair cell""]",,"Any of approximately 3,500 hair cells, situated in the organ of Corti, specialized as transducers of sound waves into nerve impulses and believed to encode information about the frequency of sound. So called because they are further from the outside of the cochlea than are the outer hair cells.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Any of approximately 3,500 hair cells, situated in the organ of Corti, specialized as transducers of sound waves into nerve impulses and believed to encode information about the frequency of sound. So called because they are further from the outside of the cochlea than are the outer hair cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003667,,,,,,,BrendaTissueOBO,,BTO:0003667,,,,,,,,,,,,,,,,,,,inner hair cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_214,"[""teeth hard tissue disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1091,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:214,,,,ICD9CM:521.8|ICD10CM:K03.89|UMLS_CUI:C0029770|ICD9CM:521.89|SNOMEDCT_US_2016_03_01:197505001|ICD10CM:K03.8,,,disease_ontology,,DOID:214,,,,,,,,,,,,,,,,,,,teeth hard tissue disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_219,"[""colon cancer""]",,A colorectal cancer that is located_in the colon.,false,,,http://purl.obolibrary.org/obo/DOID_9256,,,,,,,,A colorectal cancer that is located_in the colon.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:219,,,,UMLS_CUI:C0007102|SNOMEDCT_US_2016_03_01:363406005|SNOMEDCT_US_2016_03_01:269461008|MESH:D003110|ICD10CM:C18.9|ICD10CM:C18|SNOMEDCT_US_2016_03_01:269542007|SNOMEDCT_US_2016_03_01:187759003|SNOMEDCT_US_2016_03_01:154463007|ICD9CM:153.9|ICD9CM:153|SNOMEDCT_US_2016_03_01:93761005|NCI:C9242,,,disease_ontology,,DOID:219,http://purl.obolibrary.org/obo/doid#DO_cancer_slim|http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,colon cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_216,"[""dental caries""]",,,false,,,http://purl.obolibrary.org/obo/DOID_214,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:216,,,DOID:10870|DOID:11913|DOID:10785,ICD9CM:521.0|SNOMEDCT_US_2016_03_01:196307002|EFO:0003819|UMLS_CUI:C0011334|ICD9CM:521.06|ICD10CM:K02.9|ICD9CM:521.00|ICD10CM:K02|SNOMEDCT_US_2016_03_01:80967001|MESH:D003731|ICD10CM:K02.6|NCI:C52593|SNOMEDCT_US_2016_03_01:155632007|UMLS_CUI:C1456145|ICD9CM:521.07|UMLS_CUI:C1456144,Dental caries pit and fissure|Dental caries of smooth surface|Dental caries extending into pulp,,disease_ontology,,DOID:216,,,,,,,,,,,,,,,,,,,dental caries,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_217,"[""enamel caries""]",,,false,,,http://purl.obolibrary.org/obo/DOID_216,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:217,,,,UMLS_CUI:C0266853|ICD9CM:521.01|SNOMEDCT_US_2016_03_01:109570002|SNOMEDCT_US_2016_03_01:19437001|SNOMEDCT_US_2016_03_01:196303003|SNOMEDCT_US_2016_03_01:80353004,simple dental cavity|Dental caries limited to enamel|primary dental caries,,disease_ontology,,DOID:217,,,,,,,,,,,,,,,,,,,enamel caries,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400398,"[""ClC-4/CLCN4 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400341,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400398,,,,,,,,,,,,,,,,,,,,,,,,,,,,ClC-4/CLCN4 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100584,"[""Putative glycerol kinase 5""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100584,,,,,,,,,,,,,,,,,GK5,,,Q6ZS86,,,,,,,,Putative glycerol kinase 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100261,"[""Mas-related g-protein coupled receptor member x1""]",,"A mas-related G-protein coupled receptor X1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96LB2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300063,,,,,,,,"A mas-related G-protein coupled receptor X1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96LB2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100261,,,,https://pharos.nih.gov/idg/targets/Q96LB2,,,,,,,,,,,,,MRGPRX1,MRGX1|SNSR3|SNSR4,,Q96LB2,,,,,,,,Mas-related g-protein coupled receptor member x1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001668,"[""mast cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001668,,,,,,,BrendaTissueOBO,,BTO:0001668,,,,,,,,,,,,,,,,,,,mast cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200161,"[""GPR161 gene""]",,"A G-protein coupled receptor 161 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8N6U8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 161 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8N6U8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200161,,,,,,,,,,,,,,,,23432,GPR161,,,,,,,,,,,GPR161 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100589,"[""Inositol-trisphosphate 3-kinase C""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100589,,,,,,,,,,,,,,,,,ITPKC,,,Q96DU7,,,,,,,,Inositol-trisphosphate 3-kinase C,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200021,"[""AKT3 gene""]",,"The protein encoded by this gene is a member of the AKT, also called PKB,  serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400121,,,,,,,,"The protein encoded by this gene is a member of the AKT, also called PKB,  serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200021,,,,,,,,,,,,,,,,10000,AKT3,PKBG,,,,,,,,,,AKT3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000095,"[""F-9 cell""]",,"Mouse embryonal carcinoma, initiated from a testicular teratocarcinoma of a strain 129 mouse.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000306|http://purl.obolibrary.org/obo/BTO_0001437,,,,,,,,"Mouse embryonal carcinoma, initiated from a testicular teratocarcinoma of a strain 129 mouse.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000095,,,,,,,BrendaTissueOBO,F9 embryonal carcinoma cell|F9 EC cell|F9 cell|F9-EC cell,BTO:0000095,,,,,,,,,,,,,,,,,,,F-9 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200236,"[""LGR5 gene""]",,"A leucine-rich repeat-containing G-protein coupled receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O75473] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A leucine-rich repeat-containing G-protein coupled receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O75473] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200236,,,,,,,,,,,,,,,,8549,LGR5,GPR49|GPR67,,,,,,,,,,LGR5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100211,"[""Casein kinase i isoform gamma-1""]",,"A casein kinase I isoform gamma-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HCP0] |casein kinase i isoform gamma-1 (KC1G1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300170,,,,,,,,"A casein kinase I isoform gamma-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HCP0] |casein kinase i isoform gamma-1 (KC1G1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100211,,,,https://pharos.nih.gov/idg/targets/Q9HCP0,,,,,,,,,,,,,CSNK1G1,,,Q9HCP0,,,,,,,,Casein kinase i isoform gamma-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100768,"[""Secretin receptor""]",,"A secretin receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47872] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300047,,,,,,,,"A secretin receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47872] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100768,,,,https://pharos.nih.gov/idg/targets/P47872,,,,,,,,,,,,,SCTR,,,P47872,,,,,,,,Secretin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3247,"[""rhabdomyosarcoma""]",,A skeletal muscle cancer that arise from skeletal muscle progenitors.,false,,,http://purl.obolibrary.org/obo/DOID_4043,,,,,,,,A skeletal muscle cancer that arise from skeletal muscle progenitors.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3247,,,,NCI:C3359|UMLS_CUI:C0035412|MESH:D012208|SNOMEDCT_US_2016_03_01:134166003|SNOMEDCT_US_2016_03_01:30924005|SNOMEDCT_US_2016_03_01:302847003,,,disease_ontology,,DOID:3247,,,,,,,,,,,,,,,,,,,rhabdomyosarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400380,"[""Acid-sensing ion channel 5 (ASIC5) subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400330,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400380,,,,,,,,,,,,,,,,,,,,,,,,,,,,Acid-sensing ion channel 5 (ASIC5) subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200020,"[""ACKR4 gene""]",,"A C-C chemokine receptor type 11 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NPB9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400031,,,,,,,,"A C-C chemokine receptor type 11 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NPB9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200020,,,,,,,,,,,,,,,,51554,ACKR4,CCBP2|CCR11|CCRL1|VSHK1,,,,,,,,,,ACKR4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200192,"[""GPR34 gene""]",,"A G-protein coupled receptor 34 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UPC5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 34 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UPC5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200192,,,,,,,,,,,,,,,,2857,GPR34,,,,,,,,,,,GPR34 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_15,"[""reproductive system disease""]",,A disease of anatomical entity that is located_in reproductive system organs.,false,,,http://purl.obolibrary.org/obo/DOID_7,,,,,,,,A disease of anatomical entity that is located_in reproductive system organs.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:15,,,DOID:6309,NCI:C27613|UMLS_CUI:C1335037,genital system disease,,disease_ontology,,DOID:15,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,reproductive system disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_154,"[""mixed cell type cancer""]",,A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from two germinal layers of tissue.,false,,,http://purl.obolibrary.org/obo/DOID_0050687,,,,,,,,A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from two germinal layers of tissue.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:154,,,DOID:1905,SNOMEDCT_US_2016_03_01:189802003|UMLS_CUI:C1368354|NCI:C6930|SNOMEDCT_US_2016_03_01:8145008|NCI:C3729|UMLS_CUI:C0206625|MESH:D018198,"malignant mixed cancer|mixed tumor, malignant (morphologic abnormality)|mixed tumor|malignant mixed neoplasm|mixed tumor, malignant, NOS (morphologic abnormality)",,disease_ontology,malignant mixed tumor|mixed neoplasm,DOID:154,,,,,,,,,,,,,,,,,,,mixed cell type cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_150,"[""disease of mental health""]",,"A disease that involves a psychological or behavioral pattern generally associated with subjective distress or disability that occurs in an individual, and which are not a part of normal development or culture.",false,,,http://purl.obolibrary.org/obo/DOID_4,,,,,,,,"A disease that involves a psychological or behavioral pattern generally associated with subjective distress or disability that occurs in an individual, and which are not a part of normal development or culture.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:150,,,,SNOMEDCT_US_2016_03_01:74732009|SNOMEDCT_US_2016_03_01:154980002|SNOMEDCT_US_2016_03_01:154971002|SNOMEDCT_US_2016_03_01:192639003|MESH:D001523|NCI:C2893|UMLS_CUI:C0004936|SNOMEDCT_US_2016_03_01:192637001|ICD10CM:F99-F99|SNOMEDCT_US_2016_03_01:154972009|ICD10CM:F99|SNOMEDCT_US_2016_03_01:154843007,,,disease_ontology,,DOID:150,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,disease of mental health,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000058,"[""Arginine vasotocin""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000058,,,,,,,,,,,,,,,,,,,,,,,,,,,,Arginine vasotocin,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200217,"[""CAMK1G gene""]",,"This gene encodes a protein similar to calcium/calmodulin dependent protein kinase, however, its exact function is not known. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400171,,,,,,,,"This gene encodes a protein similar to calcium/calmodulin dependent protein kinase, however, its exact function is not known. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200217,,,,,,,,,,,,,,,,57172,CAMK1G,CLICK3|VWS1,,,,,,,,,,CAMK1G gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200334,"[""OR11H7 gene""]",,"An olfactory receptor 11H7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 11H7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200334,,,,,,,,,,,,,,,,390441,OR11H7,OR11H7P,,,,,,,,,,OR11H7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005772,"[""HO-8910PM""]",,Highly metastatic human ovarian cancer cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000811,,,,,,,,Highly metastatic human ovarian cancer cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005772,Marion,2015-09-28T09:29:59Z,,,,,BrendaTissueOBO,,BTO:0005772,,,,,,,,,,,,,,,,,,,HO-8910PM,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005672,"[""LNCaP-C4-2 cell""]",,"LNCaP and its derivative cell lines, which include C4-2 and the related C4-2B and CL1, are used as models of prostate cancer.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"LNCaP and its derivative cell lines, which include C4-2 and the related C4-2B and CL1, are used as models of prostate cancer.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005672,Marion,2014-09-05T10:26:51Z,,,,,BrendaTissueOBO,LNCaP-C4-2 cell|C4-2 cell,BTO:0005672,,,,,,,,,,,,,,,,,,,LNCaP-C4-2 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200707,"[""OR8S1 gene""]",,"An olfactory receptor 8S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH09] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 8S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH09] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200707,,,,,,,,,,,,,,,,341568,OR8S1,,,,,,,,,,,OR8S1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000363,"[""THR529 in BRAF(V600E)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000363,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR529 in BRAF(V600E),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300540,"[""Kv2.2/KCNB2 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300442,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300540,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv2.2/KCNB2 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200072,"[""CLCN1 gene""]",,"The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two forms of inherited human muscle disorders: recessive generalized myotonia congenita (Becker) and dominant myotonia (Thomsen). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400395,,,,,,,,"The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two forms of inherited human muscle disorders: recessive generalized myotonia congenita (Becker) and dominant myotonia (Thomsen). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200072,,,,,,,,,,,,,,,,1180,CLCN1,CLC1,,,,,,,,,,CLCN1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100587,"[""Olfactory receptor 4F4""]",,"An olfactory receptor 4F4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R69] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4F4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R69] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100587,,,,https://pharos.nih.gov/idg/targets/Q96R69,,,,,,,,,,,,,OR4F4,,,Q96R69,,,,,,,,Olfactory receptor 4F4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001528,"[""B-lymphoblast""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000772,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001528,,,,,,,BrendaTissueOBO,,BTO:0001528,,,,,,,,,,,,,,,,,,,B-lymphoblast,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300408,"[""Gamma-aminobutyric acid receptor subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300328,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300408,,,,,,,,,,,,,,,,,,,,,,,,,,,,Gamma-aminobutyric acid receptor subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002178,"[""HMEpC cell""]",,Human Mammary Epithelial Cells (HMEpC) are derived from normal adult mammary glands.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002768,,,,,,,,Human Mammary Epithelial Cells (HMEpC) are derived from normal adult mammary glands.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002178,,,,,,,BrendaTissueOBO,HMEC cell|human mammary epithelial cell,BTO:0002178,,,,,,,,,,,,,,,,,,,HMEpC cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400289,"[""MAPKAPK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400188,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400289,,,,,,,,,,,,,,,,,,,,,,,,,,,,MAPKAPK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200135,"[""EPHB2 gene""]",,"Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400153,,,,,,,,"Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200135,,,,,,,,,,,,,,,,2048,EPHB2,DRT|EPHT3|EPTH3,,,,,,,,,,EPHB2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400183,"[""LMR family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400183,,,,,,,,,,,,,,,,,,,,,,,,,,,,LMR family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100340,"[""Olfactory receptor 13C2""]",,"An olfactory receptor 13C2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 13C2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100340,,,,https://pharos.nih.gov/idg/targets/Q8NGS9,,,,,,,,,,,,,OR13C2,,,Q8NGS9,,,,,,,,Olfactory receptor 13C2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200018,"[""ADK gene""]",,"This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400322,,,,,,,,"This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200018,,,,,,,,,,,,,,,,132,ADK,,,,,,,,,,,ADK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117513,"[""Steroid hormone receptor err1""]",,"A steroid hormone receptor ERR1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11474] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117473,,,,,,,,"A steroid hormone receptor ERR1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11474] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117513,,,,https://pharos.nih.gov/idg/targets/P11474,,,,,,,,,,,,,ESRRA,ESRL1,,P11474,,,,,,,,Steroid hormone receptor err1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9538,"[""multiple myeloma""]",,A myeloid neoplasm that is located_in the plasma cells in bone marrow.,false,,,http://purl.obolibrary.org/obo/DOID_0070004|http://purl.obolibrary.org/obo/DOID_9500,,,,,,,,A myeloid neoplasm that is located_in the plasma cells in bone marrow.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9538,,,,ICD10CM:C90.00|NCI:C3242|MESH:D009101|EFO:0001378|OMIM:254500|SNOMEDCT_US_2016_03_01:94705007|ICD9CM:203.0|UMLS_CUI:C0026764|SNOMEDCT_US_2016_03_01:154585004|ICD10CM:C90.0|SNOMEDCT_US_2016_03_01:55921005|SNOMEDCT_US_2016_03_01:109989006,plasma cell myeloma,,disease_ontology,,DOID:9538,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,multiple myeloma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100304,"[""Map/microtubule affinity-regulating kinase 3""]",,"A MAP/microtubule affinity-regulating kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P27448] |MAP/microtubule affinity-regulating kinase 3 (MARK3)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300290,,,,,,,,"A MAP/microtubule affinity-regulating kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P27448] |MAP/microtubule affinity-regulating kinase 3 (MARK3)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100304,,,,https://pharos.nih.gov/idg/targets/P27448,,,,,,,,,,,,,MARK3,CTAK1|EMK2,,P27448,,,,,,,,Map/microtubule affinity-regulating kinase 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000390,"[""endosperm""]",,A triploid nutritive tissue resulting from the fusion of a haploid sperm nucleus with the two haploid polar nuclei in the ovule of angiosperms.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A triploid nutritive tissue resulting from the fusion of a haploid sperm nucleus with the two haploid polar nuclei in the ovule of angiosperms.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000390,,,,,,,BrendaTissueOBO,,BTO:0000390,,,,,,,,,,,,,,,,,,,endosperm,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200253,"[""MLC1 gene""]",,"The function of this gene product is unknown; however, homology to other proteins suggests that it may be an integral membrane transporter. Mutations in this gene have been associated with megalencephalic leukoencephalopathy with subcortical cysts, an autosomal recessive neurological disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400362,,,,,,,,"The function of this gene product is unknown; however, homology to other proteins suggests that it may be an integral membrane transporter. Mutations in this gene have been associated with megalencephalic leukoencephalopathy with subcortical cysts, an autosomal recessive neurological disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200253,,,,,,,,,,,,,,,,23209,MLC1,KIAA0027|WKL1,,,,,,,,,,MLC1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300397,"[""ClC-3/CLCN3 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300341,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300397,,,,,,,,,,,,,,,,,,,,,,,,,,,,ClC-3/CLCN3 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400174,"[""CAMKK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400174,,,,,,,,,,,,,,,,,,,,,,,,,,,,CAMKK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9598,"[""fasciitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_65,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9598,,,,SNOMEDCT_US_2016_03_01:36948007|SNOMEDCT_US_2016_03_01:203123000|ICD9CM:729.4|NCI:C50559|ICD10CM:M72.9|MESH:D005208|UMLS_CUI:C0015645,,,disease_ontology,,DOID:9598,,,,,,,,,,,,,,,,,,,fasciitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002320,"[""cardiac muscle fiber""]",,"Cardiac muscle fibers contain one or sometimes two nuclei and myofibrils and are separated from one another by an intercalated disk; although striated, cardiac muscle fibers branch to form an interlacing network.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Cardiac muscle fibers contain one or sometimes two nuclei and myofibrils and are separated from one another by an intercalated disk; although striated, cardiac muscle fibers branch to form an interlacing network.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002320,,,,,,,BrendaTissueOBO,cardiac muscle cell|cardiac myocyte|cardiomyocyte,BTO:0002320,,,,,,,,,,,,,,,,,,,cardiac muscle fiber,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4362,"[""cervical cancer""]",,A female reproductive organ cancer that is located_in the cervix.,false,,,http://purl.obolibrary.org/obo/DOID_120,,,,,,,,A female reproductive organ cancer that is located_in the cervix.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4362,,,DOID:4361,OMIM:603956|NCI:C2940|SNOMEDCT_US_2016_03_01:93752005|SNOMEDCT_US_2016_03_01:123841004|NCI:C9311|MESH:D002583|SNOMEDCT_US_2016_03_01:188186008|UMLS_CUI:C0007873|ICD10CM:C53|SNOMEDCT_US_2016_03_01:188174005|SNOMEDCT_US_2016_03_01:363354003|ICD9CM:180|ICD10CM:C53.9|UMLS_CUI:C0007847|SNOMEDCT_US_2016_03_01:254885005|ICD9CM:180.9,uterine cervical neoplasm|neoplasm of uterine cervix (disorder)|tumor of the Cervix Uteri|cervical neoplasm|cervix cancer|cervix uteri cancer,,disease_ontology,,DOID:4362,http://purl.obolibrary.org/obo/doid#DO_cancer_slim|http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,cervical cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200225,"[""KCNK16 gene""]",,"The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400359,,,,,,,,"The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200225,,,,,,,,,,,,,,,,83795,KCNK16,TALK1,,,,,,,,,,KCNK16 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100601,"[""Olfactory receptor 4n2""]",,"An olfactory receptor 4N2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4N2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100601,,,,https://pharos.nih.gov/idg/targets/Q8NGD1,,,,,,,,,,,,,OR4N2,,,Q8NGD1,,,,,,,,Olfactory receptor 4n2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100822,"[""Vomeronasal type-1 receptor 3""]",,"A vomeronasal type-1 receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BXE9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300016,,,,,,,,"A vomeronasal type-1 receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BXE9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100822,,,,https://pharos.nih.gov/idg/targets/Q9BXE9,,,,,,,,,,,,,VN1R3,V1RL3,,Q9BXE9,,,,,,,,Vomeronasal type-1 receptor 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100411,"[""Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma""]",,"phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PI42C)  with  no mutation  in a nonphosphorylated state|A phosphatidylinositol 5-phosphate 4-kinase type-2 gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TBX8] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300323,,,,,,,,"phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PI42C)  with  no mutation  in a nonphosphorylated state|A phosphatidylinositol 5-phosphate 4-kinase type-2 gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TBX8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100411,,,,https://pharos.nih.gov/idg/targets/Q8TBX8,,,,,,,,,,,,,PIP4K2C,PIP5K2C,,Q8TBX8,,,,,,,,Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10873,"[""Kuhnt-Junius degeneration""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2007,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10873,,,,ICD10CM:H35.32|SNOMEDCT_US_2016_03_01:11290001|UMLS_CUI:C0271084|SNOMEDCT_US_2016_03_01:16018000|ICD9CM:362.52|SNOMEDCT_US_2016_03_01:414173003,"Exudative senile macular degeneration of retina|Wet senile macular retinal degeneration|Senile macular degeneration, wet|Neovascular age-related macular degeneration",,disease_ontology,,DOID:10873,,,,,,,,,,,,,,,,,,,Kuhnt-Junius degeneration,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10871,"[""age related macular degeneration""]",,A degeneration of macula and posterior pole that is characterized by a loss of vision in the center of the visual field (the macula) resulting from damage to the retina and resulting in blurring of the sharp central vision.,false,,,http://purl.obolibrary.org/obo/DOID_2007,,,,,,,,A degeneration of macula and posterior pole that is characterized by a loss of vision in the center of the visual field (the macula) resulting from damage to the retina and resulting in blurring of the sharp central vision.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10871,,,,SNOMEDCT_US_2016_03_01:193384000|SNOMEDCT_US_2016_03_01:267718000|SNOMEDCT_US_2016_03_01:193385004|ICD10CM:H35.30|OMIM:PS603075|SNOMEDCT_US_2016_03_01:18222007|NCI:C84391|SNOMEDCT_US_2016_03_01:155112007|EFO:0001365|ICD9CM:362.50|UMLS_CUI:C0242383|SNOMEDCT_US_2016_03_01:302891003|MESH:D008268,Senile macular retinal degeneration|age-related macular degeneration|Senile macular degeneration,,disease_ontology,,DOID:10871,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,age related macular degeneration,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200401,"[""OR51J1 gene""]",,"An olfactory receptor 51J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H342] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 51J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H342] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200401,,,,,,,,,,,,,,,,79470,OR51J1,OR51J1P|OR51J2,,,,,,,,,,OR51J1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000600,"[""heterocyst""]",,A large transparent thick-walled cell that is found in the filaments of some blue-green algae and is the site of nitrogen fixation.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A large transparent thick-walled cell that is found in the filaments of some blue-green algae and is the site of nitrogen fixation.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000600,,,,,,,BrendaTissueOBO,,BTO:0000600,,,,,,,,,,,,,,,,,,,heterocyst,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100148,"[""Tyrosine-protein kinase fes/fps""]",,"A tyrosine-protein kinase Fes/Fps that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07332] |tyrosine-protein kinase fes/fps (FES)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300157,,,,,,,,"A tyrosine-protein kinase Fes/Fps that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07332] |tyrosine-protein kinase fes/fps (FES)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100148,,,,https://pharos.nih.gov/idg/targets/P07332,,,,,,,,,,,,,FES,FPS,,P07332,,,,,,,,Tyrosine-protein kinase fes/fps,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300158,"[""FGFR family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300158,,,,,,,,,,,,,,,,,,,,,,,,,,,,FGFR family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200146,"[""HCN3 gene""]",,"This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400343,,,,,,,,"This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200146,,,,,,,,,,,,,,,,57657,HCN3,KIAA1535,,,,,,,,,,HCN3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4430,"[""somatostatinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_169,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4430,,,,UMLS_CUI:C0037661|SNOMEDCT_US_2016_03_01:253006001|MESH:D013005|SNOMEDCT_US_2016_03_01:128642005|NCI:C3379,Somatostatin cell tumour|Somatostatin cell neoplasm,,disease_ontology,,DOID:4430,,,,,,,,,,,,,,,,,,,somatostatinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001997,"[""arteriole""]",,A small branch of an artery (a vessel that carries blood high in oxygen away from the heart to the body) leading to a capillary. The oxygenated hemoglobin (oxyhemoglobin) makes the blood in arteries and arterioles look bright red.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A small branch of an artery (a vessel that carries blood high in oxygen away from the heart to the body) leading to a capillary. The oxygenated hemoglobin (oxyhemoglobin) makes the blood in arteries and arterioles look bright red.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001997,,,,,,,BrendaTissueOBO,,BTO:0001997,,,,,,,,,,,,,,,,,,,arteriole,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200409,"[""PIP4K2A gene""]",,"Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400323,,,,,,,,"Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200409,,,,,,,,,,,,,,,,5305,PIP4K2A,PIP5K2|PIP5K2A,,,,,,,,,,PIP4K2A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200252,"[""MCU gene""]",,"This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400361,,,,,,,,"This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200252,,,,,,,,,,,,,,,,90550,MCU,C10orf42|CCDC109A,,,,,,,,,,MCU gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391039,"[""Phosphorylase b kinase regulatory chain family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300102,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391039,,,,,,,,,,,,,,,,,,,,,,,,,,,,Phosphorylase b kinase regulatory chain family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100311,"[""Transmembrane channel-like protein 3""]",,"A transmembrane channel-like protein 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z5M5] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300372,,,,,,,,"A transmembrane channel-like protein 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z5M5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100311,,,,https://pharos.nih.gov/idg/targets/Q7Z5M5,,,,,,,,,,,,,TMC3,,,Q7Z5M5,,,,,,,,Transmembrane channel-like protein 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000141,"[""EPHB1 kinase domain""]",,Ephrin type-B receptor 1; ELK; EPHB1; EPHT2; FLJ37986; Hek6; NET,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Ephrin type-B receptor 1; ELK; EPHB1; EPHT2; FLJ37986; Hek6; NET,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000141,,,,,,,,,,,,,,,,,,,200143,,,,,,,,,EPHB1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000089,"[""MET101 in TAOK3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000089,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET101 in TAOK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200546,"[""TTBK2 gene""]",,"This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. [provided by RefSeq, Aug 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400239,,,,,,,,"This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. [provided by RefSeq, Aug 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200546,,,,,,,,,,,,,,,,146057,TTBK2,KIAA0847,,,,,,,,,,TTBK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000412,"[""SNARK kinase domain""]",,"NUAK family, SNF1-like kinase, 2; DKFZp434J037; DKFZp686F01113; FLJ90349; NUAK2; SNARK",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"NUAK family, SNF1-like kinase, 2; DKFZp434J037; DKFZp686F01113; FLJ90349; NUAK2; SNARK",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000412,,,,,,,,,,,,,,,,,,,200413,,,,,,,,,SNARK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100046,"[""Q861 in EGFR(L861Q)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100046,,,,,,,,,,,,,,,,,,,,,,,,,,,,Q861 in EGFR(L861Q),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100191,"[""Potassium voltage-gated channel subfamily c member 3""]",,"A voltage-gated potassium channel KCNC3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14003] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300543,,,,,,,,"A voltage-gated potassium channel KCNC3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14003] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100191,,,,https://pharos.nih.gov/idg/targets/Q14003,,,,,,,,,,,,,KCNC3,,,Q14003,,,,,,,,Potassium voltage-gated channel subfamily c member 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300032,"[""Cadherin EGF LAG (CELSR) receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300032,,,,,,,,,,,,,,,,,,,,,,,,,,,,Cadherin EGF LAG (CELSR) receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14452,"[""hypokalemic periodic paralysis""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_1029,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14452,,,,NCI:C84775|OMIM:170400|OMIM:613345|SNOMEDCT_US_2016_03_01:240093008|ICD10CM:G72.3|UMLS_CUI:C0238358|SNOMEDCT_US_2016_03_01:193241004|MESH:D020514|SNOMEDCT_US_2016_03_01:82732003,familial hypokalemic periodic paralysis (disorder)|Hypokalemic familial periodic paralysis|periodic hypokalemic paralysis|familial periodic paralysis (& [hypokalaemic])|Hypokalemic periodic paralysis (disorder)|Periodic paralysis I,,disease_ontology,,DOID:14452,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,hypokalemic periodic paralysis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14451,"[""hyperkalemic periodic paralysis""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_1029,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14451,,,,UMLS_CUI:C0238357|SNOMEDCT_US_2016_03_01:15973007|ICD10CM:G72.3|OMIM:170500|SNOMEDCT_US_2016_03_01:304737009|NCI:C123429|MESH:D020513|SNOMEDCT_US_2016_03_01:278513006,familial hyperkalemic periodic paralysis (disorder)|familial hyperkalemic periodic paralysis (disorder) [Ambiguous]|hyperkalemic periodic paralysis (disorder),,disease_ontology,,DOID:14451,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,hyperkalemic periodic paralysis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100537,"[""Tribbles homolog 3""]",,"A tribbles homolog 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RU7] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300237,,,,,,,,"A tribbles homolog 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RU7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100537,,,,https://pharos.nih.gov/idg/targets/Q96RU7,,,,,,,,,,,,,TRIB3,C20orf97|NIPK|SKIP3|TRB3,,Q96RU7,,,,,,,,Tribbles homolog 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000045,"[""Alpha-MSH""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000045,,,,,,,,,,,,,,,,,,,,,,,,,,,,Alpha-MSH,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001456,"[""white adipose tissue""]",,The adipose tissue comprising the bulk of the body fat.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001487,,,,,,,,The adipose tissue comprising the bulk of the body fat.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001456,,,,,,,BrendaTissueOBO,,BTO:0001456,,,,,,,,,,,,,,,,,,,white adipose tissue,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1339,"[""Diamond-Blackfan anemia""]",,A congenital hypoplastic anemia that is characterized by anemia (low red blood cell counts) with decreased erythroid progenitors in the bone marrow and has_material_basis insufficient levels of red blood cells due to bone marrow dysfunction.,false,,,http://purl.obolibrary.org/obo/DOID_1342,,,,,,,,A congenital hypoplastic anemia that is characterized by anemia (low red blood cell counts) with decreased erythroid progenitors in the bone marrow and has_material_basis insufficient levels of red blood cells due to bone marrow dysfunction.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1339,,,,OMIM:606129|ICD10CM:D61.01|SNOMEDCT_US_2016_03_01:188588001|OMIM:614900|OMIM:105650|SNOMEDCT_US_2016_03_01:191235004|OMIM:613309|UMLS_CUI:C1260899|OMIM:612528|OMIM:615550|OMIM:615909|MESH:D029503|NCI:C61236|OMIM:612527|SNOMEDCT_US_2016_03_01:88854002|OMIM:612562|OMIM:610629|SNOMEDCT_US_2016_03_01:234371002|OMIM:612563|OMIM:613308|ORDO:124|OMIM:612561|SNOMEDCT_US_2016_03_01:191239005,Blackfan - Diamond syndrome|chronic constitutional pure red cell anaemia,,disease_ontology,,DOID:1339,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,Diamond-Blackfan anemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13399,"[""color blindness""]",,"A blindness that is characterized by the inability or decreased ability to see color, or perceive color differences, under normal lighting conditions.",false,,,http://purl.obolibrary.org/obo/DOID_1432,,,,,,,,"A blindness that is characterized by the inability or decreased ability to see color, or perceive color differences, under normal lighting conditions.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13399,,,,SNOMEDCT_US_2016_03_01:193683001|UMLS_CUI:C0242225|SNOMEDCT_US_2016_03_01:53481002|ICD10CM:H53.5|ICD10CM:H53.50|SNOMEDCT_US_2016_03_01:193685008|SNOMEDCT_US_2016_03_01:155143000|MESH:D003117|ICD9CM:368.5|NCI:C3891,Colour blindness|BLINDNESS COLOR|Colour vision deficiency,,disease_ontology,,DOID:13399,,,,,,,,,,,,,,,,,,,color blindness,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200526,"[""TEK gene""]",,"This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400234,,,,,,,,"This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200526,,,,,,,,,,,,,,,,7010,TEK,TIE2|VMCM|VMCM1,,,,,,,,,,TEK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300584,"[""TRPM2 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300483,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300584,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPM2 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004772,"[""WRO cell""]",,Follicular thyroid tumor cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003874,,,,,,,,Follicular thyroid tumor cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004772,mgr,2010-10-02T11:03:05Z,,,,,BrendaTissueOBO,,BTO:0004772,,,,,,,,,,,,,,,,,,,WRO cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100580,"[""Olfactory receptor 4D6""]",,"An olfactory receptor 4D6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4D6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100580,,,,https://pharos.nih.gov/idg/targets/Q8NGJ1,,,,,,,,,,,,,OR4D6,,,Q8NGJ1,,,,,,,,Olfactory receptor 4D6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100436,"[""Dna-dependent protein kinase catalytic subunit""]",,"A DNA-dependent protein kinase catalytic subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:P78527] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300309,,,,,,,,"A DNA-dependent protein kinase catalytic subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:P78527] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100436,,,,https://pharos.nih.gov/idg/targets/P78527,,,,,,,,,,,,,PRKDC,HYRC|HYRC1,,P78527,,,,,,,,Dna-dependent protein kinase catalytic subunit,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000350,"[""PIK3CA(Q546K) kinase domain""]",,"Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000350,,,,,,,,,,,,,,,,,,,200332,,,,,,,,,PIK3CA(Q546K) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200513,"[""OR2B2 gene""]",,"An olfactory receptor 2B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZK3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZK3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200513,,,,,,,,,,,,,,,,81697,OR2B2,OR2B9,,,,,,,,,,OR2B2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300555,"[""Kv12.2/KCNH3 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300448,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300555,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv12.2/KCNH3 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2348,"[""arteriosclerotic cardiovascular disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2349,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2348,,,,MESH:D050197|SNOMEDCT_US_2016_03_01:195121002|SNOMEDCT_US_2016_03_01:194848007|ICD9CM:440|SNOMEDCT_US_2016_03_01:195251000|ICD10CM:I25.1|ICD10CM:I70|UMLS_CUI:C0004153|UMLS_CUI:C3665365|SNOMEDCT_US_2016_03_01:38716007|SNOMEDCT_US_2016_03_01:155382007|NCI:C35771|SNOMEDCT_US_2016_03_01:155414001|SNOMEDCT_US_2016_03_01:266318005|NCI:C34403|SNOMEDCT_US_2016_03_01:39468009|NCI:C35768,"Atherosclerotic Cardiovascular disease|Atherosclerotic cardiovascular disease|Arteriosclerotic cardiovascular disease, NOS|Cardiovascular arteriosclerosis unspecified (disorder)|Arteriosclerotic cardiovascular disease|Arteriosclerotic Cardiovascular disease",,disease_ontology,,DOID:2348,,,,,,,,,,,,,,,,,,,arteriosclerotic cardiovascular disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200396,"[""PDK2 gene""]",,"This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400306,,,,,,,,"This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200396,,,,,,,,,,,,,,,,5164,PDK2,PDHK2,,,,,,,,,,PDK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200353,"[""OR14C36 gene""]",,"An olfactory receptor 14C36 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHC7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 14C36 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHC7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200353,,,,,,,,,,,,,,,,127066,OR14C36,OR5BF1,,,,,,,,,,OR14C36 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200702,"[""OR8J2 gene""]",,"An olfactory receptor 8J2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 8J2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200702,,,,,,,,,,,,,,,,81169,OR8J2,OR8J2P,,,,,,,,,,OR8J2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000021,"[""ABL1(T315I)-nonphosphorylated kinase domain""]",,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",false,,,http://www.drugtargetontology.org/dto/DTO_61000020,,,,,,,,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000021,,,,,,,,,,,,,,,,,,,"200019, 200020",,,,,,,,,ABL1(T315I)-nonphosphorylated kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200074,"[""CDK8 gene""]",,"The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400257,,,,,,,,"The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200074,,,,,,,,,,,,,,,,1024,CDK8,,,,,,,,,,,CDK8 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200540,"[""OR2M3 gene""]",,"An olfactory receptor 2M3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG83] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2M3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG83] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200540,,,,,,,,,,,,,,,,127062,OR2M3,OR2M3P|OR2M6,,,,,,,,,,OR2M3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000038,"[""LPA""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000038,,,,,,,,,,,,,,,,,,,,,,,,,,,,LPA,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100037,"[""M1196 in ALK(L1196M)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100037,,,,,,,,,,,,,,,,,,,,,,,,,,,,M1196 in ALK(L1196M),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100456,"[""Rho-associated protein kinase 1""]",,"rho-associated protein kinase 1 (ROCK1)  with  no mutation  in a nonphosphorylated state|A rho-associated protein kinase 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13464] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300313,,,,,,,,"rho-associated protein kinase 1 (ROCK1)  with  no mutation  in a nonphosphorylated state|A rho-associated protein kinase 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13464] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100456,,,,https://pharos.nih.gov/idg/targets/Q13464,,,,,,,,,,,,,ROCK1,,,Q13464,,,,,,,,Rho-associated protein kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200168,"[""GUCY2F gene""]",,"The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa. [provided by RefSeq, Dec 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400125,,,,,,,,"The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa. [provided by RefSeq, Dec 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200168,,,,,,,,,,,,,,,,2986,GUCY2F,GUC2F|RETGC2,,,,,,,,,,GUCY2F gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100013,"[""Adenosine receptor a1""]",,"An adenosine receptor A1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30542] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300018,,,,,,,,"An adenosine receptor A1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30542] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100013,,,,https://pharos.nih.gov/idg/targets/P30542,,,,,,,,,,,,,ADORA1,,,P30542,,,,,,,,Adenosine receptor a1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300242,"[""VEGFR family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300242,,,,,,,,,,,,,,,,,,,,,,,,,,,,VEGFR family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200034,"[""ATR gene""]",,"The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400251,,,,,,,,"The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200034,,,,,,,,,,,,,,,,545,ATR,FRP1,,,,,,,,,,ATR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100503,"[""Olfactory receptor 1n2""]",,"An olfactory receptor 1N2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1N2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100503,,,,https://pharos.nih.gov/idg/targets/Q8NGR9,,,,,,,,,,,,,OR1N2,,,Q8NGR9,,,,,,,,Olfactory receptor 1n2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100190,"[""Potassium voltage-gated channel subfamily c member 2""]",,"A voltage-gated potassium channel KCNC2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q96PR1] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300542,,,,,,,,"A voltage-gated potassium channel KCNC2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q96PR1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100190,,,,https://pharos.nih.gov/idg/targets/Q96PR1,,,,,,,,,,,,,KCNC2,,,Q96PR1,,,,,,,,Potassium voltage-gated channel subfamily c member 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400299,"[""NIM1 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400116,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400299,,,,,,,,,,,,,,,,,,,,,,,,,,,,NIM1 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000381,"[""RIOK2 kinase domain""]",,RIO kinase 2 (yeast); FLJ11159; RIO2; RIOK2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,RIO kinase 2 (yeast); FLJ11159; RIO2; RIOK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000381,,,,,,,,,,,,,,,,,,,200375,,,,,,,,,RIOK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217563,"[""ESRRA gene""]",,"The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_00217473,,,,,,,,"The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217563,,,,,,,,,,,,,,,,2101,ESRRA,ERR1|ESRL1|NR3B1,,,,,,,,,,ESRRA gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5221,"[""chronic polyneuropathy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1389,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5221,,,,UMLS_CUI:C1167650|NCI:C36071,,,disease_ontology,,DOID:5221,,,,,,,,,,,,,,,,,,,chronic polyneuropathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100395,"[""Olfactory receptor 51F2""]",,"An olfactory receptor 51F2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH61] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 51F2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH61] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100395,,,,https://pharos.nih.gov/idg/targets/Q8NH61,,,,,,,,,,,,,OR51F2,,,Q8NH61,,,,,,,,Olfactory receptor 51F2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100090,"[""Cyclic nucleotide-gated cation channel beta-3""]",,"A cyclic nucleotide-gated cation channel beta-3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9NQW8] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300407,,,,,,,,"A cyclic nucleotide-gated cation channel beta-3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9NQW8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100090,,,,https://pharos.nih.gov/idg/targets/Q9NQW8,,,,,,,,,,,,,CNGB3,,,Q9NQW8,,,,,,,,Cyclic nucleotide-gated cation channel beta-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004650,"[""dorsal fin""]",,"The unpaired fin located on the back of both bony fish and sharks. It may be single and soft-rayed, as in trout, or double with the anterior dorsal fin supported by fin spines, as in perch. In some species, e.g. eels, the dorsal fin is confluent with the tail fin.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0004649,,,,,,,,"The unpaired fin located on the back of both bony fish and sharks. It may be single and soft-rayed, as in trout, or double with the anterior dorsal fin supported by fin spines, as in perch. In some species, e.g. eels, the dorsal fin is confluent with the tail fin.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004650,mgr,2010-05-05T08:09:41Z,,,,,BrendaTissueOBO,,BTO:0004650,,,,,,,,,,,,,,,,,,,dorsal fin,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217554,"[""NR2C1 gene""]",,"This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_00217469,,,,,,,,"This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217554,,,,,,,,,,,,,,,,7181,NR2C1,TR2,,,,,,,,,,NR2C1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050753,"[""cerebellar ataxia""]",,A cerebellar disease characterized by ataxia originating in the cerebellum.,false,,,http://purl.obolibrary.org/obo/DOID_2786,,,,,,,,A cerebellar disease characterized by ataxia originating in the cerebellum.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050753,lschriml,2013-01-16T01:07:02Z,,,,,disease_ontology,,DOID:0050753,,,,,,,,,,,,,,,,,,,cerebellar ataxia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050757,"[""deafness dystonia syndrome""]",,"A mitochondrial metabolism disease that is characterized by hearing loss that begins early in life, problems with movement, impaired vision, and behavior problems.",false,,,http://purl.obolibrary.org/obo/DOID_700,,,,,,,,"A mitochondrial metabolism disease that is characterized by hearing loss that begins early in life, problems with movement, impaired vision, and behavior problems.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050757,lschriml,2013-01-16T01:20:50Z,,OMIM:304700,Deafness Dystonia Optic Neuronopathy Syndrome (DDON)|Dystonia Deafness Syndrome|Deafness Dystonia Optic Atrophy Syndrome|Mohr-Tranebjaerg Syndrome,,disease_ontology,,DOID:0050757,,,,,,,,,,,,,,,,,,,deafness dystonia syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050758,"[""metabolic acidosis""]",,A lactic acidosis that has_material_basis_in high levels of acid.,false,,,http://purl.obolibrary.org/obo/DOID_3650,,,,,,,,A lactic acidosis that has_material_basis_in high levels of acid.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050758,lschriml,2013-01-16T01:23:37Z,,,,,disease_ontology,,DOID:0050758,,,,,,,,,,,,,,,,,,,metabolic acidosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200147,"[""FER gene""]",," Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400157,,,,,,,," Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200147,,,,,,,,,,,,,,,,2241,FER,TYK3,,,,,,,,,,FER gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002051,"[""preosteoblast""]",,A mesenchymal cell that differentiates into an osteoblast.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002050,,,,,,,,A mesenchymal cell that differentiates into an osteoblast.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002051,,,,,,,BrendaTissueOBO,osteoprogenitor cell,BTO:0002051,,,,,,,,,,,,,,,,,,,preosteoblast,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400337,"[""PMP-22/EMP/MP20 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400337,,,,,,,,,,,,,,,,,,,,,,,,,,,,PMP-22/EMP/MP20 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050622,"[""reproductive organ benign neoplasm""]",,An organ system benign neoplasm that is located_in reproductive system organs.,false,,,http://purl.obolibrary.org/obo/DOID_0060085,,,,,,,,An organ system benign neoplasm that is located_in reproductive system organs.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050622,,,,,,,disease_ontology,,DOID:0050622,,,,,,,,,,,,,,,,,,,reproductive organ benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050624,"[""gastrointestinal system benign neoplasm""]",,An organ system benign neoplasm located_in gastrointestinal tract organs.,false,,,http://purl.obolibrary.org/obo/DOID_0060085|http://purl.obolibrary.org/obo/DOID_77,,,,,,,,An organ system benign neoplasm located_in gastrointestinal tract organs.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050624,,,,,,,disease_ontology,,DOID:0050624,,,,,,,,,,,,,,,,,,,gastrointestinal system benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050628,"[""advanced sleep phase syndrome""]",,A sleep disorder that involves an altered circadian rhythm resulting in falling asleep in early evening and awaking very early in the morning.,false,,,http://purl.obolibrary.org/obo/DOID_535,,,,,,,,A sleep disorder that involves an altered circadian rhythm resulting in falling asleep in early evening and awaking very early in the morning.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050628,,,,ORDO:164736|OMIM:PS604348,familial advanced sleep-phase syndrome,,disease_ontology,,DOID:0050628,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,advanced sleep phase syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050621,"[""respiratory system benign neoplasm""]",,An organ system benign neoplasm that is located_in the respiratory system which extends from the nasal sinuses to the diaphragm.,false,,,http://purl.obolibrary.org/obo/DOID_0060085|http://purl.obolibrary.org/obo/DOID_1579,,,,,,,,An organ system benign neoplasm that is located_in the respiratory system which extends from the nasal sinuses to the diaphragm.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050621,,,,,,,disease_ontology,,DOID:0050621,,,,,,,,,,,,,,,,,,,respiratory system benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100021,"[""Acetylcholine receptor subunit gamma""]",,"An acetylcholine receptor subunit gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07510] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300505,,,,,,,,"An acetylcholine receptor subunit gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07510] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100021,,,,https://pharos.nih.gov/idg/targets/P07510,,,,,,,,,,,,,CHRNG,ACHRG,,P07510,,,,,,,,Acetylcholine receptor subunit gamma,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200162,"[""KCNJ6 gene""]",,"Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and may be involved in the regulation of insulin secretion by glucose. It associates with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400433,,,,,,,,"Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and may be involved in the regulation of insulin secretion by glucose. It associates with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200162,,,,,,,,,,,,,,,,3763,KCNJ6,GIRK2|KATP2|KCNJ7,,,,,,,,,,KCNJ6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200493,"[""OR1J2 gene""]",,"An olfactory receptor 1J2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1J2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200493,,,,,,,,,,,,,,,,26740,OR1J2,OR1J3|OR1J5,,,,,,,,,,OR1J2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100641,"[""Olfactory receptor 5M11""]",,"An olfactory receptor 5M11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RB7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5M11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RB7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100641,,,,https://pharos.nih.gov/idg/targets/Q96RB7,,,,,,,,,,,,,OR5M11,,,Q96RB7,,,,,,,,Olfactory receptor 5M11,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000292,"[""MP2K7 kinase domain""]",,Dual specificity mitogen-activated protein kinase kinase 7,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Dual specificity mitogen-activated protein kinase kinase 7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000292,,,,,,,,,,,,,,,,,,,200263,,,,,,,,,MP2K7 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100436,"[""Olfactory receptor 52W1""]",,"An olfactory receptor 52W1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF63] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 52W1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF63] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100436,,,,https://pharos.nih.gov/idg/targets/Q6IF63,,,,,,,,,,,,,OR52W1,OR52W1P,,Q6IF63,,,,,,,,Olfactory receptor 52W1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1659,"[""supratentorial cancer""]",,A brain cancer that is located_in the supratentorial region.,false,,,http://purl.obolibrary.org/obo/DOID_1319,,,,,,,,A brain cancer that is located_in the supratentorial region.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1659,,,DOID:1658,NCI:C4964|UMLS_CUI:C0038874|UMLS_CUI:C0751589|MESH:D015173|NCI:C3397|ICD10CM:C71.0,"Brain neoplasm, Supratentorial|malignant Supratentorial tumor",,disease_ontology,,DOID:1659,,,,,,,,,,,,,,,,,,,supratentorial cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200520,"[""TESK1 gene""]",,"This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400319,,,,,,,,"This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200520,,,,,,,,,,,,,,,,7016,TESK1,,,,,,,,,,,TESK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100387,"[""Serine/threonine-protein kinase pak 4""]",,"serine/threonine-protein kinase pak 4 (PAK4)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase PAK 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O96013] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300304,,,,,,,,"serine/threonine-protein kinase pak 4 (PAK4)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase PAK 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O96013] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100387,,,,https://pharos.nih.gov/idg/targets/O96013,,,,,,,,,,,,,PAK4,KIAA1142,,O96013,,,,,,,,Serine/threonine-protein kinase pak 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391026,"[""GHMP kinase family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300324,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391026,,,,,,,,,,,,,,,,,,,,,,,,,,,,GHMP kinase family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001613,"[""colorectum""]",,The colon and rectum considered as a unit.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The colon and rectum considered as a unit.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001613,,,,,,,BrendaTissueOBO,,BTO:0001613,,,,,,,,,,,,,,,,,,,colorectum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100323,"[""Short transient receptor potential channel 5""]",,"A short transient receptor potential channel 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UL62] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300580,,,,,,,,"A short transient receptor potential channel 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UL62] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100323,,,,https://pharos.nih.gov/idg/targets/Q9UL62,,,,,,,,,,,,,TRPC5,TRP5,,Q9UL62,,,,,,,,Short transient receptor potential channel 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200524,"[""TGFBR2 gene""]",,"This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400252,,,,,,,,"This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200524,,,,,,,,,,,,,,,,7048,TGFBR2,,,,,,,,,,,TGFBR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100463,"[""Olfactory receptor 7E24""]",,"An olfactory receptor 7E24 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IFN5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 7E24 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IFN5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100463,,,,https://pharos.nih.gov/idg/targets/Q6IFN5,,,,,,,,,,,,,OR7E24,OR7E24P,,Q6IFN5,,,,,,,,Olfactory receptor 7E24,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300457,"[""NR2C/GRIN2C subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300457,,,,,,,,,,,,,,,,,,,,,,,,,,,,NR2C/GRIN2C subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001020,"[""periodontal ligament""]",,"The fibrous connective tissue that surrounds the root of a tooth, separating it from and attaching it to the alveolar bone. It extends from the base of the gingival mucosa to the fundus of the bony socket, and its main function is to hold the tooth in its socket.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The fibrous connective tissue that surrounds the root of a tooth, separating it from and attaching it to the alveolar bone. It extends from the base of the gingival mucosa to the fundus of the bony socket, and its main function is to hold the tooth in its socket.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001020,,,,,,,BrendaTissueOBO,paradentium|alveolodental ligament|peridental membrane|peridontium|alveolar periosteum|desmodontium|odontoperiosteum|alveolodental membrane|peridontal membrane,BTO:0001020,,,,,,,,,,,,,,,,,,,periodontal ligament,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100754,"[""Parathyroid hormone/parathyroid hormone-related peptide receptor""]",,"A parathyroid hormone/parathyroid hormone-related peptide receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q03431] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300084,,,,,,,,"A parathyroid hormone/parathyroid hormone-related peptide receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q03431] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100754,,,,https://pharos.nih.gov/idg/targets/Q03431,,,,,,,,,,,,,PTH1R,PTHR|PTHR1,,Q03431,,,,,,,,Parathyroid hormone/parathyroid hormone-related peptide receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100614,"[""Olfactory receptor 5b3""]",,"An olfactory receptor 5B3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH48] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5B3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH48] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100614,,,,https://pharos.nih.gov/idg/targets/Q8NH48,,,,,,,,,,,,,OR5B3,OR5B13,,Q8NH48,,,,,,,,Olfactory receptor 5b3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060224,"[""atrial fibrillation""]",,"A heart conduction disease that is characterized by uncoordinated electrical activity in the heart's upper chambers (the atria), which causes the heartbeat to become fast and irregular and has symptoms palpitations, weakness, fatigue, lightheadedness, dizziness, confusion, shortness of breath and chest pain.",false,,,http://purl.obolibrary.org/obo/DOID_10273,,,,,,,,"A heart conduction disease that is characterized by uncoordinated electrical activity in the heart's upper chambers (the atria), which causes the heartbeat to become fast and irregular and has symptoms palpitations, weakness, fatigue, lightheadedness, dizziness, confusion, shortness of breath and chest pain.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060224,emitraka,2015-01-16T14:55:21Z,,ICD10CM:I48|SNOMEDCT_US_2016_03_01:49436004|HP:0005110|SNOMEDCT_US_2016_03_01:266306001|NCI:C50466|ICD9CM:427.31|MESH:D001281|SNOMEDCT_US_2016_03_01:155364009|UMLS_CUI:C0004238,A-fib,,disease_ontology,,DOID:0060224,,,,,,,,,,,,,,,,,,,atrial fibrillation,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060229,"[""Baraitser-Winter syndrome""]",,"A syndrome characterized by distinctive facial features including hypertelorism, large eyelid openings, ptosis, high-arched eyebrows, a broad nasal bridge and tip of the nose, a long space between the nose and the upper lip, full cheeks and a pointed chin; structural abnormalities of the brain might also be present.",false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,"A syndrome characterized by distinctive facial features including hypertelorism, large eyelid openings, ptosis, high-arched eyebrows, a broad nasal bridge and tip of the nose, a long space between the nose and the upper lip, full cheeks and a pointed chin; structural abnormalities of the brain might also be present.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060229,emitraka,2015-01-16T16:52:25Z,,OMIM:243310|OMIM:614583|ICD10CM:Q87.0,,,disease_ontology,,DOID:0060229,,,,,,,,,,,,,,,,,Xref MGI.,,Baraitser-Winter syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060220,"[""physical urticaria""]",,An urticaria induced by external physical influences.,false,,,http://purl.obolibrary.org/obo/DOID_1555,,,,,,,,An urticaria induced by external physical influences.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060220,emitraka,2014-11-21T15:51:38Z,,,,,disease_ontology,,DOID:0060220,,,,,,,,,,,,,,,,,WD correction.,,physical urticaria,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060221,"[""Maffucci syndrome""]",,A syndrome characterized by the presence of multiple enchondromas (benign growths of cartilage) associated with multiple hemangiomas.,false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,A syndrome characterized by the presence of multiple enchondromas (benign growths of cartilage) associated with multiple hemangiomas.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060221,emitraka,2014-11-26T11:16:24Z,,OMIM:614569|ICD10CM:Q78.4|ORDO:163634,,,disease_ontology,,DOID:0060221,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,WD former synonym.,,Maffucci syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000091,"[""ascites""]",,Accumulation of serous fluid in the spaces between tissues and organs in the cavity of the abdomen.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Accumulation of serous fluid in the spaces between tissues and organs in the cavity of the abdomen.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000091,,,,,,,BrendaTissueOBO,ascitic fluid|ascites fluid,BTO:0000091,,,,,,,,,,,,,,,,,,,ascites,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001450,"[""vitelline membrane""]",,"The cytoplasmic, noncellular membrane surrounding the eggs of various animals, especially the membrane enveloping the yolk of telolecithal eggs.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The cytoplasmic, noncellular membrane surrounding the eggs of various animals, especially the membrane enveloping the yolk of telolecithal eggs.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001450,,,,,,,BrendaTissueOBO,yolk sac membrane,BTO:0001450,,,,,,,,,,,,,,,,,,,vitelline membrane,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000465,"[""YES kinase domain""]",,Tyrosine-protein kinase Yes; Proto-oncogene tyrosine-protein kinase Yes,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Tyrosine-protein kinase Yes; Proto-oncogene tyrosine-protein kinase Yes,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000465,,,,,,,,,,,,,,,,,,,200465,,,,,,,,,YES kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004212,"[""seta""]",,"A hair-like unicellular external process of the body wall or any derivative of the latter, a hair, a bristle.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001501,,,,,,,,"A hair-like unicellular external process of the body wall or any derivative of the latter, a hair, a bristle.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004212,,,,,,,BrendaTissueOBO,bristle,BTO:0004212,,,,,,,,,,,,,,,,,,,seta,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200423,"[""PIK3CB gene""]",,"This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03491009,,,,,,,,"This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200423,,,,,,,,,,,,,,,,5291,PIK3CB,PIK3C1,,,,,,,,,,PIK3CB gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200498,"[""OR1L4 gene""]",,"An olfactory receptor 1L4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1L4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200498,,,,,,,,,,,,,,,,254973,OR1L4,OR1L5,,,,,,,,,,OR1L4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100123,"[""Glucagon-like peptide 2 receptor""]",,"A glucagon-like peptide 2 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95838] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300047,,,,,,,,"A glucagon-like peptide 2 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95838] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100123,,,,https://pharos.nih.gov/idg/targets/O95838,,,,,,,,,,,,,GLP2R,,,O95838,,,,,,,,Glucagon-like peptide 2 receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300121,"[""AKT family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300121,,,,,,,,,,,,,,,,,,,,,,,,,,,,AKT family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2962,"[""Cockayne syndrome""]",,"An autosomal recessive disease that has material basis in rare mutations in two DNA excision repair proteins, ERCC-8 and ERCC-6, and characterized by growth failure, impaired development of the nervous system, abnormal sensitivity to sunlight (photosensitivity), and premature aging.",false,,,http://purl.obolibrary.org/obo/DOID_37|http://purl.obolibrary.org/obo/DOID_0050737,,,,,,,,"An autosomal recessive disease that has material basis in rare mutations in two DNA excision repair proteins, ERCC-8 and ERCC-6, and characterized by growth failure, impaired development of the nervous system, abnormal sensitivity to sunlight (photosensitivity), and premature aging.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2962,,,,SNOMEDCT_US_2016_03_01:205832003|NCI:C9460|SNOMEDCT_US_2016_03_01:21086008|MESH:D003057|UMLS_CUI:C0009207|OMIM:216400|ORDO:90321|ORDO:90324|ICD10CM:Q87.1|ORDO:191|ORDO:90322|OMIM:216411|OMIM:133540,Neill-Dingwall syndrome,,disease_ontology,Cockayne's syndrome,DOID:2962,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,Cockayne syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200264,"[""LATS1 gene""]",,"The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. Two protein-coding transcripts and one non-protein coding transcript have been found for this gene. [provided by RefSeq, Jul 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400181,,,,,,,,"The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. Two protein-coding transcripts and one non-protein coding transcript have been found for this gene. [provided by RefSeq, Jul 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200264,,,,,,,,,,,,,,,,9113,LATS1,WARTS,,,,,,,,,,LATS1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000178,"[""MET469 in MAP3K14""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000178,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET469 in MAP3K14,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001285,"[""sporangiophore""]",,A stalk or similar structure bearing sporangia in plants and fungi.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000468,,,,,,,,A stalk or similar structure bearing sporangia in plants and fungi.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001285,,,,,,,BrendaTissueOBO,,BTO:0001285,,,,,,,,,,,,,,,,,,,sporangiophore,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200440,"[""OR56A4 gene""]",,"An olfactory receptor 56A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 56A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200440,,,,,,,,,,,,,,,,120793,OR56A4,,,,,,,,,,,OR56A4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400376,"[""Acid-sensing ion channel 1 (ASIC1) subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400330,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400376,,,,,,,,,,,,,,,,,,,,,,,,,,,,Acid-sensing ion channel 1 (ASIC1) subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400546,"[""Kv4.2/KCND2 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400444,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400546,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv4.2/KCND2 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8717,"[""decubitus ulcer""]",,Decubitus ulcer is a chronic ulcer of skin where the ulcer is an ulceration of tissue deprived of adequate blood supply by prolonged pressure.,false,,,http://purl.obolibrary.org/obo/DOID_8549,,,,,,,,Decubitus ulcer is a chronic ulcer of skin where the ulcer is an ulceration of tissue deprived of adequate blood supply by prolonged pressure.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8717,,,DOID:8808|DOID:9002|DOID:9029|DOID:9129,SNOMEDCT_US_2016_03_01:165258002|SNOMEDCT_US_2016_03_01:90144002|ICD10CM:L89.9|SNOMEDCT_US_2016_03_01:418172001|ICD10CM:L89|SNOMEDCT_US_2016_03_01:142668003|ICD9CM:707.0|SNOMEDCT_US_2016_03_01:420226006|SNOMEDCT_US_2016_03_01:156424003|UMLS_CUI:C0011127|ICD9CM:707.00|SNOMEDCT_US_2016_03_01:201248003|MESH:D003668|SNOMEDCT_US_2016_03_01:28103007|NCI:C50706|SNOMEDCT_US_2016_03_01:400192002|SNOMEDCT_US_2016_03_01:399912005,"Decubitus ulcer any site|Decubitus ulcer, elbow|Decubitus ulcer, other site|Decubitus (pressure) ulcer|Decubitus ulcer, lower back|Decubitus ulcer|Decubitus ulcer, upper back|pressure sores|pressure ulcer",,disease_ontology,bedsore,DOID:8717,,,,,,,,,,,,,,,,,,,decubitus ulcer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1474,"[""aggressive periodontitis""]",,A periodontitis that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as dental plaque and dental calculus resulting in inflammation and a loss of periodontium.,false,,,http://purl.obolibrary.org/obo/DOID_824,,,,,,,,A periodontitis that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as dental plaque and dental calculus resulting in inflammation and a loss of periodontium.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1474,,,,MESH:D010520|ICD10CM:K05.2|OMIM:608526|UMLS_CUI:C0031106|SNOMEDCT_US_2016_03_01:49965002|SNOMEDCT_US_2016_03_01:2624008|SNOMEDCT_US_2016_03_01:449908004|OMIM:170650,juvenile periodontitis,,disease_ontology,,DOID:1474,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,aggressive periodontitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14749,"[""methylmalonic acidemia""]",,An organic acidemia that involves an accumulation of methylmalonic acid in the blood.,false,,,http://purl.obolibrary.org/obo/DOID_0060159,,,,,,,,An organic acidemia that involves an accumulation of methylmalonic acid in the blood.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14749,,,DOID:14802|DOID:14782,,"methylmalonic aciduria type cblA|methylmalonic aciduria mut type|METHYLMALONIC ACIDEMIA, cblB TYPE|METHYLMALONIC ACIDURIA, VITAMIN B12-RESPONSIVE, DUE TO DEFECT IN SYNTHESIS OF ADENOSYLCOBALAMIN, cblB TYPE|METHYLMALONIC ACIDURIA, mut TYPE|METHYLMALONICACIDURIA DUE TO METHYLMALONIC CoA MUTASE deficiency|METHYLMALONIC ACIDEMIA, cblA TYPE|methylmalonic aciduria|METHYLMALONICACIDURIA, vitamin B12-RESPONSIVE, DUE TO DEFECT IN SYNTHESIS OF ADENOSYLCOBALAMIN--cbl B|METHYLMALONIC ACIDURIA DUE TO METHYLMALONYL-CoA MUTASE DEFICIENCY|methylmalonic aciduria cblB type|methylmalonic aciduria type cblB|METHYLMALONICACIDURIA, vitamin B12-RESPONSIVE, DUE TO DEFECT IN SYNTHESIS OF ADENOSYLCOBALAMIN--cbl A|METHYLMALONIC ACIDURIA, VITAMIN B12-RESPONSIVE, DUE TO DEFECT IN SYNTHESIS OF ADENOSYLCOBALAMIN, cblA TYPE",,disease_ontology,,DOID:14749,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,methylmalonic acidemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14744,"[""Partington syndrome""]",,"A syndrome characterized by intellectual disability, focal dystonia of the hands and dysarthria.",false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,"A syndrome characterized by intellectual disability, focal dystonia of the hands and dysarthria.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14744,,,,ORDO:94083|MESH:C562446|OMIM:309510|UMLS_CUI:C0220775|OMIM:312780,X-linked Russell-Silver syndrome,,disease_ontology,,DOID:14744,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"OMIM mapping confirmed by DO. [SN].
OMIM mapping submitted by NeuroDevNet. [LS].",,Partington syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14748,"[""Sotos syndrome""]",,An autosomal recessive disease that occurs rarely and is characterized by excessive physical growth during the first 2 to 3 years of life.,false,,,http://purl.obolibrary.org/obo/DOID_0050737,,,,,,,,An autosomal recessive disease that occurs rarely and is characterized by excessive physical growth during the first 2 to 3 years of life.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14748,,,,ICD10CM:Q87.3|NCI:C75019|MESH:D058495|SNOMEDCT_US_2016_03_01:75968004|OMIM:614753|ORDO:821|UMLS_CUI:C0175695|OMIM:117550,cerebral gigantism,,disease_ontology,,DOID:14748,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,Sotos syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100231,"[""Histamine h2 receptor""]",,"A histamine H2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25021] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300061,,,,,,,,"A histamine H2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25021] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100231,,,,https://pharos.nih.gov/idg/targets/P25021,,,,,,,,,,,,,HRH2,,,P25021,,,,,,,,Histamine h2 receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000287,"[""PHE89 in CAMK2A""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000287,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE89 in CAMK2A,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002029,"[""myoma cell""]",,A cell of a benign tumor made up of muscular elements.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A cell of a benign tumor made up of muscular elements.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002029,,,,,,,BrendaTissueOBO,,BTO:0002029,,,,,,,,,,,,,,,,,,,myoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001116,"[""floral primordium""]",,"Immediately next to the growing inflorescence tip is the floral primordium, which is a bump of cells representing the very youngest stage of a flower.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0005525,,,,,,,,"Immediately next to the growing inflorescence tip is the floral primordium, which is a bump of cells representing the very youngest stage of a flower.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001116,,,,,,,BrendaTissueOBO,,BTO:0001116,,,,,,,,,,,,,,,,,,,floral primordium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100300,"[""Olfactory receptor 10G2""]",,"An olfactory receptor 10G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100300,,,,https://pharos.nih.gov/idg/targets/Q8NGC3,,,,,,,,,,,,,OR10G2,,,Q8NGC3,,,,,,,,Olfactory receptor 10G2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001610,"[""thyroid cancer cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001876,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001610,,,,,,,BrendaTissueOBO,,BTO:0001610,,,,,,,,,,,,,,,,,,,thyroid cancer cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200582,"[""OR4D10 gene""]",,"An olfactory receptor 4D10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4D10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200582,,,,,,,,,,,,,,,,390197,OR4D10,OR4D10P,,,,,,,,,,OR4D10 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100107,"[""Frizzled-5""]",,"A frizzled-5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13467] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300043,,,,,,,,"A frizzled-5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13467] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100107,,,,https://pharos.nih.gov/idg/targets/Q13467,,,,,,,,,,,,,FZD5,C2orf31,,Q13467,,,,,,,,Frizzled-5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5076,"[""mixed glioma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3070,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5076,,,,NCI:C3903|SNOMEDCT_US_2016_03_01:443937008|SNOMEDCT_US_2016_03_01:22217002|UMLS_CUI:C0259783|MESH:D005910,mixed glioma (morphologic abnormality)|mixed gliomas|mixed Neuroglial tumor,,disease_ontology,,DOID:5076,,,,,,,,,,,,,,,,,,,mixed glioma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1400,"[""lacrimal apparatus disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5614,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1400,,,,SNOMEDCT_US_2016_03_01:155185001|SNOMEDCT_US_2016_03_01:155181005|ICD9CM:375|SNOMEDCT_US_2016_03_01:194003009|ICD10CM:H04.9|NCI:C26809|ICD10CM:H04|SNOMEDCT_US_2016_03_01:267740009|ICD9CM:375.9|UMLS_CUI:C0022904|MESH:D007766|SNOMEDCT_US_2016_03_01:31053003,,,disease_ontology,,DOID:1400,,,,,,,,,,,,,,,,,,,lacrimal apparatus disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14004,"[""thoracic aortic aneurysm""]",,An aortic aneurysm that is located_in the thoracic aorta.,false,,,http://purl.obolibrary.org/obo/DOID_3627,,,,,,,,An aortic aneurysm that is located_in the thoracic aorta.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14004,,,,OMIM:132900|ORDO:91387|SNOMEDCT_US_2016_03_01:155421001|OMIM:615436|MESH:D017545|OMIM:613780|SNOMEDCT_US_2016_03_01:433068007|EFO:0004282|UMLS_CUI:C0162872|OMIM:607087|OMIM:611788|NCI:C27001|OMIM:607086,,,disease_ontology,,DOID:14004,,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,thoracic aortic aneurysm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100153,"[""Tyrosine-protein kinase fgr""]",,"tyrosine-protein kinase fgr (FGR)  with  no mutation  in a nonphosphorylated state|A tyrosine-protein kinase Fgr that is encoded in the genome of human. [PRO:DNx, UniProtKB:P09769] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300132,,,,,,,,"tyrosine-protein kinase fgr (FGR)  with  no mutation  in a nonphosphorylated state|A tyrosine-protein kinase Fgr that is encoded in the genome of human. [PRO:DNx, UniProtKB:P09769] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100153,,,,https://pharos.nih.gov/idg/targets/P09769,,,,,,,,,,,,,FGR,SRC2,,P09769,,,,,,,,Tyrosine-protein kinase fgr,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100818,"[""Vasoactive intestinal polypeptide receptor 1""]",,"A vasoactive intestinal polypeptide receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P32241] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300003,,,,,,,,"A vasoactive intestinal polypeptide receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P32241] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100818,,,,https://pharos.nih.gov/idg/targets/P32241,,,,,,,,,,,,,VIPR1,,,P32241,,,,,,,,Vasoactive intestinal polypeptide receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000424,"[""VAL564 in FGFR2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000424,,,,,,,,,,,,,,,,,,,,,,,,,,,,VAL564 in FGFR2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400140,"[""CLK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400111,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400140,,,,,,,,,,,,,,,,,,,,,,,,,,,,CLK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000334,"[""THR315 in ABL1(M351T)-phosphorylated""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000334,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR315 in ABL1(M351T)-phosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80303,"[""Pituitary adenylate cyclase-activating peptide-27""]",PACAP-27,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16089,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,PACAP-27,,,CHEBI:80303,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80303,,,,,Pituitary adenylate cyclase-activating peptide-27,,CHEBI:80303,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200537,"[""OR2L8 gene""]",,"An olfactory receptor 2L8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2L8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200537,,,,,,,,,,,,,,,,391190,OR2L8,,,,,,,,,,,OR2L8 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100492,"[""Serine/threonine-protein kinase 32b""]",,"A serine/threonine-protein kinase 32B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NY57] |serine/threonine-protein kinase 32b (YANK2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300227,,,,,,,,"A serine/threonine-protein kinase 32B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NY57] |serine/threonine-protein kinase 32b (YANK2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100492,,,,https://pharos.nih.gov/idg/targets/Q9NY57,,,,,,,,,,,,,STK32B,YANK2,,Q9NY57,,,,,,,,Serine/threonine-protein kinase 32b,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400220,"[""SEV family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400220,,,,,,,,,,,,,,,,,,,,,,,,,,,,SEV family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200045,"[""C3AR1 gene""]",,"A C3a anaphylatoxin chemotactic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q16581] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400027,,,,,,,,"A C3a anaphylatoxin chemotactic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q16581] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200045,,,,,,,,,,,,,,,,719,C3AR1,AZ3B|C3R1|HNFAG09,,,,,,,,,,C3AR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100086,"[""Endothelin-1 receptor""]",,"An endothelin-1 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25101] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300098,,,,,,,,"An endothelin-1 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25101] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100086,,,,https://pharos.nih.gov/idg/targets/P25101,,,,,,,,,,,,,EDNRA,ETA|ETRA,,P25101,,,,,,,,Endothelin-1 receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005224,"[""hFOB 1.19 cell""]",,Human fetal osteoblast cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0004324|http://purl.obolibrary.org/obo/BTO_0001242,,,,,,,,Human fetal osteoblast cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005224,XPMUser,2011-09-03T08:47:31Z,,,,,BrendaTissueOBO,hFOB1.19 cell,BTO:0005224,,,,,,,,,,,,,,,,,,,hFOB 1.19 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5176,"[""renal Wilms' tumor""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2154,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5176,,,,NCI:C6951|UMLS_CUI:C1335062,Nonanaplastic renal Wilm's tumor,,disease_ontology,nonanaplastic renal wilms tumor,DOID:5176,,,,,,,,,,,,,,,,,,,renal Wilms' tumor,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000329,"[""PCTK2 kinase domain""]",,Cyclin-dependent kinase 17; CDK17; PCTAIRE2; PCTK2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Cyclin-dependent kinase 17; CDK17; PCTAIRE2; PCTK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000329,,,,,,,,,,,,,,,,,,,200310,,,,,,,,,PCTK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200028,"[""NPR1 gene""]",,"Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400125,,,,,,,,"Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200028,,,,,,,,,,,,,,,,4881,NPR1,ANPRA,,,,,,,,,,NPR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001307,"[""stomach""]",,A dilatation of the alimentary canal of a vertebrate communicating anteriorly with the esophagus and posteriorly with the duodenum.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,,A dilatation of the alimentary canal of a vertebrate communicating anteriorly with the esophagus and posteriorly with the duodenum.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001307,,,,,,,BrendaTissueOBO,gaster,BTO:0001307,,,,,,,,,,,,,,,,,,,stomach,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100114,"[""Gamma-aminobutyric acid type b receptor subunit 2""]",,"A gamma-aminobutyric acid type B receptor subunit 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75899] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300045,,,,,,,,"A gamma-aminobutyric acid type B receptor subunit 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75899] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100114,,,,https://pharos.nih.gov/idg/targets/O75899,,,,,,,,,,,,,GABBR2,GPR51|GPRC3B,,O75899,,,,,,,,Gamma-aminobutyric acid type b receptor subunit 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5238,"[""benign perivascular tumor""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060091,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5238,,,,UMLS_CUI:C1332532|NCI:C6529,,,disease_ontology,,DOID:5238,,,,,,,,,,,,,,,,,,,benign perivascular tumor,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_30006,"[""L-leucine residue""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_33700,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:30006,,,,RESID:AA0011,L-leucine residue,,chebi_ontology,L|L-leucine|-Leu-|113.084|C6H11NO|L-leucyl|113.15768|0|Leu,CHEBI:30006,http://purl.obolibrary.org/obo/chebi#3_STAR,,,,,,,,,,,,,,,,,,L-leucine residue,,,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000142,"[""MET180 in MYLK4""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000142,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET180 in MYLK4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000437,"[""TLK2 kinase domain""]",,Serine/threonine-protein kinase tousled-like 2; tousled-like kinase 2; MGC44450; PKU-ALPHA; TLK2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase tousled-like 2; tousled-like kinase 2; MGC44450; PKU-ALPHA; TLK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000437,,,,,,,,,,,,,,,,,,,200438,,,,,,,,,TLK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8689,"[""anorexia nervosa""]",,"An eating disorder characterized by refusal to maintain a healthy body weight, and an obsessive fear of gaining weight due to a distorted self image.",false,,,http://purl.obolibrary.org/obo/DOID_8670,,,,,,,,"An eating disorder characterized by refusal to maintain a healthy body weight, and an obsessive fear of gaining weight due to a distorted self image.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8689,,,,SNOMEDCT_US_2016_03_01:192445002|SNOMEDCT_US_2016_03_01:56882008|ICD9CM:307.1|ICD10CM:F50.0|SNOMEDCT_US_2016_03_01:154926005|UMLS_CUI:C0003125|ICD10CM:F50.00|NCI:C34387|MESH:D000856,,,disease_ontology,,DOID:8689,,,,,,,,,,,,,,,,,,,anorexia nervosa,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300258,"[""CDK1 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300136,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300258,,,,,,,,,,,,,,,,,,,,,,,,,,,,CDK1 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3910,"[""lung adenocarcinoma""]",,A non-small cell lung carcinoma that derives_from epithelial cells of glandular origin.,false,,,http://purl.obolibrary.org/obo/DOID_299|http://purl.obolibrary.org/obo/DOID_3908,,,,,,,,A non-small cell lung carcinoma that derives_from epithelial cells of glandular origin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3910,,,DOID:4826,EFO:0000571|MESH:C538231|NCI:C27745|UMLS_CUI:C1335060|UMLS_CUI:C0152013|SNOMEDCT_US_2016_03_01:254626006|NCI:C3512,nonsmall cell adenocarcinoma,,disease_ontology,adenocarcinoma of lung,DOID:3910,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,lung adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5077,"[""subependymal giant cell astrocytoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4843,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5077,,,,UMLS_CUI:C0205768|NCI:C3696|SNOMEDCT_US_2016_03_01:449799008|SNOMEDCT_US_2016_03_01:1586004|MESH:D001254,Subependymal giant cell astrocytoma (morphologic abnormality)|SEGA,,disease_ontology,,DOID:5077,,,,,,,,,,,,,,,,,,,subependymal giant cell astrocytoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100161,"[""G protein-coupled receptor kinase 5""]",,"A G protein-coupled receptor kinase 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P34947] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300271,,,,,,,,"A G protein-coupled receptor kinase 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P34947] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100161,,,,https://pharos.nih.gov/idg/targets/P34947,,,,,,,,,,,,,GRK5,GPRK5,,P34947,,,,,,,,G protein-coupled receptor kinase 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5844,"[""myocardial infarction""]",,A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia.,false,,,http://purl.obolibrary.org/obo/DOID_3393,,,,,,,,A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5844,,,,SNOMEDCT_US_2016_03_01:233824008|MESH:D009203|OMIM:608446|ICD10CM:I21|SNOMEDCT_US_2016_03_01:22298006|SNOMEDCT_US_2016_03_01:266288001|NCI:C27996|UMLS_CUI:C0027051|SNOMEDCT_US_2016_03_01:155304006|SNOMEDCT_US_2016_03_01:194796000|OMIM:608557|ICD10CM:I22|SNOMEDCT_US_2016_03_01:66514008|EFO:0000612,heart attack|Myocardial infarct,,disease_ontology,,DOID:5844,,,,,,,,,,,,,,,,,Xref MGI.,,myocardial infarction,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200625,"[""RBKS gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200625,,,,,,,,,,,,,,,,,,,,,,,,,,,,RBKS gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13240,"[""tooth resorption""]",,,false,,,http://purl.obolibrary.org/obo/DOID_214,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13240,,,,UMLS_CUI:C0040451|SNOMEDCT_US_2016_03_01:196316003|SNOMEDCT_US_2016_03_01:70931000|ICD10CM:K03.3|ICD9CM:521.4|MESH:D014091,,,disease_ontology,,DOID:13240,,,,,,,,,,,,,,,,,,,tooth resorption,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1324,"[""lung cancer""]",,A respiratory system cancer that is located_in the lung.,false,,,http://purl.obolibrary.org/obo/DOID_850|http://purl.obolibrary.org/obo/DOID_0050615,,,,,,,,A respiratory system cancer that is located_in the lung.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1324,,,DOID:1322|DOID:9881|DOID:13075,SNOMEDCT_US_2016_03_01:187874006|ICD9CM:162.4|ICD9CM:162.3|OMIM:211980|ICD10CM:C34.1|OMIM:612593|OMIM:612571|SNOMEDCT_US_2016_03_01:187863002|ICD10CM:C34.2|UMLS_CUI:C0024624|UMLS_CUI:C0153492|SNOMEDCT_US_2016_03_01:269464000|SNOMEDCT_US_2016_03_01:187867001|OMIM:614210|SNOMEDCT_US_2016_03_01:187864008|ICD9CM:162.5|SNOMEDCT_US_2016_03_01:187860004|SNOMEDCT_US_2016_03_01:187868006|ICD10CM:C34.3|ICD9CM:162.8|UMLS_CUI:C0153493|UMLS_CUI:C0153491|SNOMEDCT_US_2016_03_01:187871003|OMIM:608935,,,disease_ontology,lung neoplasm,DOID:1324,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,lung cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13241,"[""Behcet's disease""]",,"A vasculitis that is characterized by an autoimmune mediated inflammation of the blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis.",false,,,http://purl.obolibrary.org/obo/DOID_865,,,,,,,,"A vasculitis that is characterized by an autoimmune mediated inflammation of the blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13241,,,,SNOMEDCT_US_2016_03_01:310701003|NCI:C34416|SNOMEDCT_US_2016_03_01:154424000|UMLS_CUI:C0004943|MESH:D001528|SNOMEDCT_US_2016_03_01:41225007|EFO:0003780|OMIM:109650|ICD10CM:M35.2|ICD9CM:136.1,Adamantiades-Behcet disease|Behet's syndrome|triple symptom complex|Behcet syndrome,,disease_ontology,Behcet's syndrome,DOID:13241,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Behcet's disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000295,"[""PHE92 in ERK8""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000295,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE92 in ERK8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9854,"[""lingual-facial-buccal dyskinesia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_480,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9854,,,,UMLS_CUI:C0152115|ICD10CM:G24.4|SNOMEDCT_US_2016_03_01:155007009|MESH:D009069|SNOMEDCT_US_2016_03_01:49386006|SNOMEDCT_US_2016_03_01:267689009|ICD9CM:333.82|SNOMEDCT_US_2016_03_01:192861006,Oro-facial dyskinesia,,disease_ontology,,DOID:9854,,,,,,,,,,,,,,,,,,,lingual-facial-buccal dyskinesia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200683,"[""OR7G2 gene""]",,"An olfactory receptor 7G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG99] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 7G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG99] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200683,,,,,,,,,,,,,,,,390882,OR7G2,,,,,,,,,,,OR7G2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000007,"[""C5a""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000007,,,,,,,,,,,,,,,,,,,,,,,,,,,,C5a,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200078,"[""CDKL3 gene""]",,"The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400138,,,,,,,,"The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200078,,,,,,,,,,,,,,,,51265,CDKL3,NKIAMRE,,,,,,,,,,CDKL3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000337,"[""THR315 in ABL1(T315I)-nonphosphorylated""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000337,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR315 in ABL1(T315I)-nonphosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200168,"[""KCNA10 gene""]",,"Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400530,,,,,,,,"Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200168,,,,,,,,,,,,,,,,3744,KCNA10,,,,,,,,,,,KCNA10 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100497,"[""Serine/threonine-protein kinase 16""]",,"serine/threonine-protein kinase 16 (STK16)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase 16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75716] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300115,,,,,,,,"serine/threonine-protein kinase 16 (STK16)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase 16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75716] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100497,,,,https://pharos.nih.gov/idg/targets/O75716,,,,,,,,,,,,,STK16,MPSK1|PKL12|TSF1,,O75716,,,,,,,,Serine/threonine-protein kinase 16,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_63000002,"[""ABC1""]",,"A Pfam protein family that includes ABC1 from yeast and AarF from E. coli . These proteins have a nuclear or mitochondrial subcellular location in eukaryotes. The exact molecular functions of these proteins is not clear, however yeast ABC1 suppresses a cytochrome b mRNA translation defect and is essential for the electron transfer in the bc 1 complex [1] and E. coli AarF is required for ubiquinone production. It has been suggested that members of the ABC1 family are novel chaperonins. These proteins are unrelated to the ABC transporter proteins.",false,,,http://www.drugtargetontology.org/dto/DTO_63000000,,,,,,,,"A Pfam protein family that includes ABC1 from yeast and AarF from E. coli . These proteins have a nuclear or mitochondrial subcellular location in eukaryotes. The exact molecular functions of these proteins is not clear, however yeast ABC1 suppresses a cytochrome b mRNA translation defect and is essential for the electron transfer in the bc 1 complex [1] and E. coli AarF is required for ubiquinone production. It has been suggested that members of the ABC1 family are novel chaperonins. These proteins are unrelated to the ABC transporter proteins.",http://pfam.xfam.org/family/PF01504|http://pfam.xfam.org/family/ABC1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_63000002,,,,,,,,,,,,,,,,,,,,,,,,,,,,ABC1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000014,"[""Beta-defensin 4A""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000014,,,,,,,,,,,,,,,,,,,,,,,,,,,,Beta-defensin 4A,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100160,"[""G protein-coupled receptor kinase 4""]",,"A G protein-coupled receptor kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P32298] |G protein-coupled receptor kinase 4 (GRK4)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300271,,,,,,,,"A G protein-coupled receptor kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P32298] |G protein-coupled receptor kinase 4 (GRK4)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100160,,,,https://pharos.nih.gov/idg/targets/P32298,,,,,,,,,,,,,GRK4,GPRK2L|GPRK4,,P32298,,,,,,,,G protein-coupled receptor kinase 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100696,"[""Olfactory receptor 8G5""]",,"An olfactory receptor 8G5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG78] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 8G5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG78] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100696,,,,https://pharos.nih.gov/idg/targets/Q8NG78,,,,,,,,,,,,,OR8G5,OR8G5P|OR8G6,,Q8NG78,,,,,,,,Olfactory receptor 8G5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4976,"[""elephantiasis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4977,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4976,,,,UMLS_CUI:C0013882|SNOMEDCT_US_2016_03_01:266334008|MESH:D004604|SNOMEDCT_US_2016_03_01:155485008|NCI:C34569|SNOMEDCT_US_2016_03_01:240820001,Elephantiasis NOS,,disease_ontology,,DOID:4976,,,,,,,,,,,,,,,,,,,elephantiasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005205,"[""cerebral artery""]",,Any of the arteries supplying blood to the cerebral cortex.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000573,,,,,,,,Any of the arteries supplying blood to the cerebral cortex.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005205,XPMUser,2011-09-02T10:00:15Z,,,,,BrendaTissueOBO,,BTO:0005205,,,,,,,,,,,,,,,,,,,cerebral artery,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000023,"[""CXCL16""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000023,,,,,,,,,,,,,,,,,,,,,,,,,,,,CXCL16,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100108,"[""Frizzled-6""]",,"A frizzled-6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60353] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300043,,,,,,,,"A frizzled-6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60353] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100108,,,,https://pharos.nih.gov/idg/targets/O60353,,,,,,,,,,,,,FZD6,,,O60353,,,,,,,,Frizzled-6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12639,"[""pyloric stenosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3122,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12639,,,,SNOMEDCT_US_2016_03_01:367403001|ICD10CM:K31.1|MESH:D011707|UMLS_CUI:C0034194|NCI:C34966,,,disease_ontology,,DOID:12639,,,,,,,,,,,,,,,,,,,pyloric stenosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100233,"[""Potassium voltage-gated channel subfamily KQT member 2""]",,A voltage-gated potassium channel subunit KCNQ2 that is encoded in the genome of human. [] ,false,,,http://www.drugtargetontology.org/dto/DTO_01300562,,,,,,,,A voltage-gated potassium channel subunit KCNQ2 that is encoded in the genome of human. [] ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100233,,,,https://pharos.nih.gov/idg/targets/O43526,,,,,,,,,,,,,KCNQ2,,,O43526,,,,,,,,Potassium voltage-gated channel subfamily KQT member 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80238,"[""T-kinin""]","InChI=1S/C59H89N17O14/c1-3-34(2)47(60)53(85)72-41(32-77)50(82)69-37(19-10-24-65-58(61)62)54(86)76-28-14-23-45(76)56(88)75-27-12-21-43(75)51(83)67-31-46(79)68-39(29-35-15-6-4-7-16-35)48(80)73-42(33-78)55(87)74-26-13-22-44(74)52(84)71-40(30-36-17-8-5-9-18-36)49(81)70-38(57(89)90)20-11-25-66-59(63)64/h4-9,15-18,34,37-45,47,77-78H,3,10-14,19-33,60H2,1-2H3,(H,67,83)(H,68,79)(H,69,82)(H,70,81)(H,71,84)(H,72,85)(H,73,80)(H,89,90)(H4,61,62,65)(H4,63,64,66)/t34-,37-,38-,39-,40-,41-,42-,43-,44-,45-,47-/m0/s1|C59H89N17O14|CC[C@H](C)[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O|1260.44350|1259.677|Ile-Ser-bradykinin|GKCWYHPGFSRBQV-WRBAKOPXSA-N|0",,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16008,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,"InChI=1S/C59H89N17O14/c1-3-34(2)47(60)53(85)72-41(32-77)50(82)69-37(19-10-24-65-58(61)62)54(86)76-28-14-23-45(76)56(88)75-27-12-21-43(75)51(83)67-31-46(79)68-39(29-35-15-6-4-7-16-35)48(80)73-42(33-78)55(87)74-26-13-22-44(74)52(84)71-40(30-36-17-8-5-9-18-36)49(81)70-38(57(89)90)20-11-25-66-59(63)64/h4-9,15-18,34,37-45,47,77-78H,3,10-14,19-33,60H2,1-2H3,(H,67,83)(H,68,79)(H,69,82)(H,70,81)(H,71,84)(H,72,85)(H,73,80)(H,89,90)(H4,61,62,65)(H4,63,64,66)/t34-,37-,38-,39-,40-,41-,42-,43-,44-,45-,47-/m0/s1|C59H89N17O14|CC[C@H](C)[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O|1260.44350|1259.677|Ile-Ser-bradykinin|GKCWYHPGFSRBQV-WRBAKOPXSA-N|0",,,CHEBI:80238,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80238,,,,,T-kinin,,CHEBI:80238,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000054,"[""BRAF kinase domain""]",,Serine/threonine-protein kinase B-raf; v-raf murine sarcoma viral oncogene homolog B1; BRAF1; RAFB1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase B-raf; v-raf murine sarcoma viral oncogene homolog B1; BRAF1; RAFB1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000054,,,,,,,,,,,,,,,,,,,200054,,,,,,,,,BRAF kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300246,"[""STKR Type 1 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300119,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300246,,,,,,,,,,,,,,,,,,,,,,,,,,,,STKR Type 1 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000219,"[""KIT(V559D) kinase domain""]",,V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; C-Kit; KIT; PBT; SCFR,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; C-Kit; KIT; PBT; SCFR,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000219,,,,,,,,,,,,,,,,,,,200219,,,,,,,,,KIT(V559D) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100102,"[""FXYD domain-containing ion transport regulator 4""]",,"An FXYD domain-containing ion transport regulator 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59646] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300348,,,,,,,,"An FXYD domain-containing ion transport regulator 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59646] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100102,,,,https://pharos.nih.gov/idg/targets/P59646,,,,,,,,,,,,,FXYD4,,,P59646,,,,,,,,FXYD domain-containing ion transport regulator 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9248,"[""Pallister-Hall syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0080015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9248,,,,MESH:D054975|UMLS_CUI:C0265220|NCI:C84987|SNOMEDCT_US_2016_03_01:56677004|OMIM:146510,Pallister-Hall syndrome (disorder),,disease_ontology,,DOID:9248,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Pallister-Hall syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100335,"[""Transient receptor potential cation channel subfamily V member 3""]",,"A transient receptor potential cation channel TRPV3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8NET8] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300592,,,,,,,,"A transient receptor potential cation channel TRPV3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8NET8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100335,,,,https://pharos.nih.gov/idg/targets/Q8NET8,,,,,,,,,,,,,TRPV3,,,Q8NET8,,,,,,,,Transient receptor potential cation channel subfamily V member 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001953,"[""tanycyte""]",,"Modified ependymal cell of the median eminence, having a body that lies near the third ventricle and sending out processes that extend to the capillary plexus of the portal circulation. Its function is unknown, but it may transport hormones from the cerebrospinal fluid into the portal circulation or from hypothalamic neurons to the cerebrospinal fluid.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Modified ependymal cell of the median eminence, having a body that lies near the third ventricle and sending out processes that extend to the capillary plexus of the portal circulation. Its function is unknown, but it may transport hormones from the cerebrospinal fluid into the portal circulation or from hypothalamic neurons to the cerebrospinal fluid.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001953,,,,,,,BrendaTissueOBO,,BTO:0001953,,,,,,,,,,,,,,,,,,,tanycyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100589,"[""Olfactory receptor 4f6""]",,"An olfactory receptor 4F6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4F6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100589,,,,https://pharos.nih.gov/idg/targets/Q8NGB9,,,,,,,,,,,,,OR4F6,OR4F12,,Q8NGB9,,,,,,,,Olfactory receptor 4f6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001474,"[""yolk sac erythroid cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001474,,,,,,,BrendaTissueOBO,,BTO:0001474,,,,,,,,,,,,,,,,,,,yolk sac erythroid cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300523,"[""GABRR3 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300523,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRR3 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100039,"[""Voltage-dependent n-type calcium channel subunit alpha-1b""]",,"A voltage-dependent N-type calcium channel subunit alpha-1B that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q00975] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300382,,,,,,,,"A voltage-dependent N-type calcium channel subunit alpha-1B that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q00975] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100039,,,,https://pharos.nih.gov/idg/targets/Q00975,,,,,,,,,,,,,CACNA1B,CACH5|CACNL1A5,,Q00975,,,,,,,,Voltage-dependent n-type calcium channel subunit alpha-1b,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1618,"[""breast fibroadenoma""]",,A breast benign neoplasm comprised of fibrous and glandoular tissues located_in breast.,false,,,http://purl.obolibrary.org/obo/DOID_0060082,,,,,,,,A breast benign neoplasm comprised of fibrous and glandoular tissues located_in breast.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1618,,,DOID:7226|DOID:2684|DOID:2693,UMLS_CUI:C1333137|SNOMEDCT_US_2016_03_01:189102001|SNOMEDCT_US_2016_03_01:189820007|UMLS_CUI:C0178421|SNOMEDCT_US_2016_03_01:269640007|UMLS_CUI:C0206650|SNOMEDCT_US_2016_03_01:65877006|SNOMEDCT_US_2016_03_01:46212000|NCI:C3744|NCI:C5194|UMLS_CUI:C0346158|MESH:D018226|SNOMEDCT_US_2016_03_01:254845004|SNOMEDCT_US_2016_03_01:254847007|ICD10CM:D24|NCI:C4276,Fibroadenoma of breast (disorder)|Fibroadenoma|Juvenile fibroadenoma (morphologic abnormality)|Complex Fibroadenoma of breast|juvenile fibroadenoma of breast|fibroadenoma|cellular Fibroadenoma,,disease_ontology,,DOID:1618,,,,,,,,,,,,,,,,,,,breast fibroadenoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000008,"[""GLN105 in MK01""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30011,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000008,,,,,,,,,,,,,,,,,,,,,,,,,,,,GLN105 in MK01,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200090,"[""ADGRE2 gene""]",,"An EGF-like module-containing mucin-like hormone receptor-like 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UHX3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,"An EGF-like module-containing mucin-like hormone receptor-like 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UHX3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200090,,,,,,,,,,,,,,,,30817,EMR2,,,,,,,,,,,ADGRE2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400063,"[""Mas proto-oncogene and Mas-related (MRGs) receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400063,,,,,,,,,,,,,,,,,,,,,,,,,,,,Mas proto-oncogene and Mas-related (MRGs) receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200664,"[""OR6M1 gene""]",,"An olfactory receptor 6M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGM8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGM8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200664,,,,,,,,,,,,,,,,390261,OR6M1,,,,,,,,,,,OR6M1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100076,"[""H(+)/cl(-) exchange transporter 5""]",,"An H(+)/Cl(-) exchange transporter 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51795] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300399,,,,,,,,"An H(+)/Cl(-) exchange transporter 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51795] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100076,,,,https://pharos.nih.gov/idg/targets/P51795,,,,,,,,,,,,,CLCN5,CLCK2,,P51795,,,,,,,,H(+)/cl(-) exchange transporter 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400129,"[""PIKK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400108,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400129,,,,,,,,,,,,,,,,,,,,,,,,,,,,PIKK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060403,"[""chromosome 17q11.2 deletion syndrome, 1.4Mb""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060388,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060403,elvira,2015-09-28T16:52:05Z,,ORDO:97685|OMIM:613675|ICD10CM:Q85.0,neurofibromatosis type 1 microdeletion syndrome|Van Asperen syndrome|NF1 microdeletion syndrome|17q11 microdeletion syndrome,,disease_ontology,,DOID:0060403,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,"chromosome 17q11.2 deletion syndrome, 1.4Mb",,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060407,"[""chromosome 18q deletion syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060388,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060407,elvira,2015-09-28T17:05:53Z,,MESH:C536580|ORDO:1600|ICD10CM:Q93.5|OMIM:601808,monosomy 18q|deletion 18q|18q- syndrome,,disease_ontology,,DOID:0060407,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,chromosome 18q deletion syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100809,"[""Thyrotropin-releasing hormone receptor""]",,"A thyrotropin-releasing hormone receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P34981] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A thyrotropin-releasing hormone receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P34981] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100809,,,,https://pharos.nih.gov/idg/targets/P34981,,,,,,,,,,,,,TRHR,,,P34981,,,,,,,,Thyrotropin-releasing hormone receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3614,"[""Kallmann syndrome""]",,A hypogonadotropic hypogonadism with a defective sense of smell (anosmia or hyposmia).,false,,,http://purl.obolibrary.org/obo/DOID_0090070,,,,,,,,A hypogonadotropic hypogonadism with a defective sense of smell (anosmia or hyposmia).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3614,,,,ICD10CM:E23.0|NCI:C75479|SNOMEDCT_US_2016_03_01:33927004|SNOMEDCT_US_2016_03_01:93559003|SNOMEDCT_US_2016_03_01:190559001|UMLS_CUI:C0162809|MESH:D017436,Kallman syndrome|Kallman's syndrome|familial hypogonadism with anosmia|Hypogonadism with anosmia (disorder),,disease_ontology,,DOID:3614,,,,,,,,,,,,,,,,,,,Kallmann syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200096,"[""CSK gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400144,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200096,,,,,,,,,,,,,,,,1445,CSK,,,,,,,,,,,CSK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100671,"[""Olfactory receptor 6V1""]",,"An olfactory receptor 6V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N148] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N148] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100671,,,,https://pharos.nih.gov/idg/targets/Q8N148,,,,,,,,,,,,,OR6V1,,,Q8N148,,,,,,,,Olfactory receptor 6V1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000005,"[""ASN289 in WEE2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_50347,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000005,,,,,,,,,,,,,,,,,,,,,,,,,,,,ASN289 in WEE2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000266,"[""MELK kinase domain""]",,Maternal embryonic leucine zipper kinase; HPK38; KIAA0175,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Maternal embryonic leucine zipper kinase; HPK38; KIAA0175,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000266,,,,,,,,,,,,,,,,,,,200257,,,,,,,,,MELK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200293,"[""SCN3A gene""]",,"Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400467,,,,,,,,"Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200293,,,,,,,,,,,,,,,,6328,SCN3A,KIAA1356|NAC3,,,,,,,,,,SCN3A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3146,"[""lipid metabolism disorder""]",,An inherited metabolic disorder that involves the creation and degradation of lipids.,false,,,http://purl.obolibrary.org/obo/DOID_655,,,,,,,,An inherited metabolic disorder that involves the creation and degradation of lipids.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3146,,,,MESH:D008052|UMLS_CUI:C0023772,dyslipidemia|fatty acid metabolism disorder,,disease_ontology,,DOID:3146,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,lipid metabolism disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400071,"[""Neuropeptide Y receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400071,,,,,,,,,,,,,,,,,,,,,,,,,,,,Neuropeptide Y receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100543,"[""Testis-specific serine/threonine-protein kinase 4""]",,"A testis-specific serine/threonine-protein kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6SA08] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300238,,,,,,,,"A testis-specific serine/threonine-protein kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6SA08] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100543,,,,https://pharos.nih.gov/idg/targets/Q6SA08,,,,,,,,,,,,,TSSK4,C14orf20|STK22E|TSSK5,,Q6SA08,,,,,,,,Testis-specific serine/threonine-protein kinase 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200177,"[""HK1 gene""]",,"Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein. [provided by RefSeq, Apr 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03491017,,,,,,,,"Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein. [provided by RefSeq, Apr 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200177,,,,,,,,,,,,,,,,3098,HK1,,,,,,,,,,,HK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100297,"[""Olfactory receptor 10C1""]",,"An olfactory receptor 10C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96KK4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96KK4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100297,,,,https://pharos.nih.gov/idg/targets/Q96KK4,,,,,,,,,,,,,OR10C1,OR10C2,,Q96KK4,,,,,,,,Olfactory receptor 10C1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400231,"[""TAF1 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400108,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400231,,,,,,,,,,,,,,,,,,,,,,,,,,,,TAF1 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200292,"[""SCN2B gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400466,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200292,,,,,,,,,,,,,,,,6327,SCN2B,,,,,,,,,,,SCN2B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000314,"[""THR265 in ACVR2B""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000314,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR265 in ACVR2B,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004114,"[""adrenocortical carcinoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004114,,,,,,,BrendaTissueOBO,,BTO:0004114,,,,,,,,,,,,,,,,,,,adrenocortical carcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200218,"[""GRM1 gene""]",,"A metabotropic glutamate receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13255] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400059,,,,,,,,"A metabotropic glutamate receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13255] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200218,,,,,,,,,,,,,,,,2911,GRM1,GPRC1A|MGLUR1,,,,,,,,,,GRM1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001597,"[""sapling""]",,A young tree; specifically: one not over four inches in diameter at breast height.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001461,,,,,,,,A young tree; specifically: one not over four inches in diameter at breast height.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001597,,,,,,,BrendaTissueOBO,,BTO:0001597,,,,,,,,,,,,,,,,,,,sapling,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10273,"[""heart conduction disease""]",,A cardiovascular system disease that involves the heart's electrical conduction system.,false,,,http://purl.obolibrary.org/obo/DOID_114,,,,,,,,A cardiovascular system disease that involves the heart's electrical conduction system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10273,,,,SNOMEDCT_US_2016_03_01:195056000|ICD9CM:426.6|UMLS_CUI:C0029630|SNOMEDCT_US_2016_03_01:195053008,heart rhythm disease,,disease_ontology,,DOID:10273,,,,,,,,,,,,,,,,,,,heart conduction disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200173,"[""HIPK2 gene""]",,"This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400273,,,,,,,,"This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200173,,,,,,,,,,,,,,,,28996,HIPK2,,,,,,,,,,,HIPK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100703,"[""Olfactory receptor 8J3""]",,"An olfactory receptor 8J3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 8J3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100703,,,,https://pharos.nih.gov/idg/targets/Q8NGG0,,,,,,,,,,,,,OR8J3,,,Q8NGG0,,,,,,,,Olfactory receptor 8J3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001347,"[""tadpole""]",,A larval amphibian; specifically: a frog or toad larva that has a rounded body with a long tail bordered by fins and external gills soon replaced by internal gills and that undergoes a metamorphosis to the adult.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000707,,,,,,,,A larval amphibian; specifically: a frog or toad larva that has a rounded body with a long tail bordered by fins and external gills soon replaced by internal gills and that undergoes a metamorphosis to the adult.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001347,,,,,,,BrendaTissueOBO,,BTO:0001347,,,,,,,,,,,,,,,,,,,tadpole,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100004,"[""5'-AMP-activated protein kinase catalytic subunit alpha-1""]",,"A 5'-AMP-activated protein kinase catalytic subunit alpha-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13131] |5-amp-activated protein kinase catalytic subunit alpha-1 (AMPK-alpha1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300245,,,,,,,,"A 5'-AMP-activated protein kinase catalytic subunit alpha-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13131] |5-amp-activated protein kinase catalytic subunit alpha-1 (AMPK-alpha1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100004,,,,https://pharos.nih.gov/idg/targets/Q13131,,,,,,,,,,,,,PRKAA1,AMPK1,,Q13131,,,,,,,,5'-AMP-activated protein kinase catalytic subunit alpha-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000339,"[""PIK3C2B kinase domain""]",,"Phosphoinositide-3-kinase, class 2, beta polypeptide; C2-PI3K; DKFZp686G16234; PIK3C2B",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Phosphoinositide-3-kinase, class 2, beta polypeptide; C2-PI3K; DKFZp686G16234; PIK3C2B",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000339,,,,,,,,,,,,,,,,,,,200321,,,,,,,,,PIK3C2B kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200426,"[""OR52K2 gene""]",,"An olfactory receptor 52K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 52K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200426,,,,,,,,,,,,,,,,119774,OR52K2,,,,,,,,,,,OR52K2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200069,"[""CDK3 gene""]",,"This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400258,,,,,,,,"This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200069,,,,,,,,,,,,,,,,1018,CDK3,CDKN3,,,,,,,,,,CDK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000199,"[""ITK kinase domain""]",,IL2-inducible T-cell kinase; EMT; ITK; LYK; MGC126257; MGC126258; PSCTK2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,IL2-inducible T-cell kinase; EMT; ITK; LYK; MGC126257; MGC126258; PSCTK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000199,,,,,,,,,,,,,,,,,,,200202,,,,,,,,,ITK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200619,"[""PFKP gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200619,,,,,,,,,,,,,,,,,,,,,,,,,,,,PFKP gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300440,"[""KCNMB/KCNMB3 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300358,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300440,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNMB/KCNMB3 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300013,"[""Olfactory receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300013,,,,,,,,,,,,,,,,,,,,,,,,,,,,Olfactory receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100336,"[""Transient receptor potential cation channel subfamily V member 4""]",,"A transient receptor potential cation channel TRPV4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9HBA0] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300593,,,,,,,,"A transient receptor potential cation channel TRPV4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9HBA0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100336,,,,https://pharos.nih.gov/idg/targets/Q9HBA0,,,,,,,,,,,,,TRPV4,VRL2|VROAC,,Q9HBA0,,,,,,,,Transient receptor potential cation channel subfamily V member 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300399,"[""ClC-5/CLCN5 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300341,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300399,,,,,,,,,,,,,,,,,,,,,,,,,,,,ClC-5/CLCN5 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400192,"[""TKL-UNIQUE family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400107,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400192,,,,,,,,,,,,,,,,,,,,,,,,,,,,TKL-UNIQUE family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3827,"[""congenital diaphragmatic hernia""]",,"A diaphragm disease characterized by the lack of development of all or part of the diaphragm, which results in an abnormal opening that allows the stomach and intestines to move into the chest cavity and crowd the heart and lungs.",false,,,http://purl.obolibrary.org/obo/DOID_10481,,,,,,,,"A diaphragm disease characterized by the lack of development of all or part of the diaphragm, which results in an abnormal opening that allows the stomach and intestines to move into the chest cavity and crowd the heart and lungs.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3827,,,,SNOMEDCT_US_2016_03_01:155748004|ICD10CM:K44|ORDO:2140|SNOMEDCT_US_2016_03_01:196911004|UMLS_CUI:C0019284|OMIM:142340|OMIM:610187|MESH:D006548|ICD10CM:K44.9|SNOMEDCT_US_2016_03_01:155750007|OMIM:222400|SNOMEDCT_US_2016_03_01:196901006|NCI:C34687|SNOMEDCT_US_2016_03_01:266444006|SNOMEDCT_US_2016_03_01:196912006|SNOMEDCT_US_2016_03_01:266511003|SNOMEDCT_US_2016_03_01:39839004,Diaphragmatic Hernia,,disease_ontology,,DOID:3827,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,congenital diaphragmatic hernia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100320,"[""Short transient receptor potential channel 1""]",,"A short transient receptor potential channel 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48995] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300577,,,,,,,,"A short transient receptor potential channel 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48995] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100320,,,,https://pharos.nih.gov/idg/targets/P48995,,,,,,,,,,,,,TRPC1,TRP1,,P48995,,,,,,,,Short transient receptor potential channel 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1432,"[""blindness""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5679,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1432,,,,SNOMEDCT_US_2016_03_01:193698004|SNOMEDCT_US_2016_03_01:267729001|UMLS_CUI:C0155020|ICD10CM:H54|SNOMEDCT_US_2016_03_01:155146008|SNOMEDCT_US_2016_03_01:155150001|ICD9CM:369,,,disease_ontology,,DOID:1432,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,blindness,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14320,"[""generalized anxiety disorder""]",,An anxiety disorder that is characterized by long-lasting anxiety that is not focused on any one object or situation.,false,,,http://purl.obolibrary.org/obo/DOID_2030,,,,,,,,An anxiety disorder that is characterized by long-lasting anxiety that is not focused on any one object or situation.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14320,,,,SNOMEDCT_US_2016_03_01:192401002|NCI:C92622|ICD10CM:F41.1|SNOMEDCT_US_2016_03_01:21897009|UMLS_CUI:C0270549|SNOMEDCT_US_2016_03_01:191706008|ICD9CM:300.02,,,disease_ontology,,DOID:14320,,,,,,,,,,,,,,,,,,,generalized anxiety disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100016,"[""H816 in KIT(D816H)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100016,,,,,,,,,,,,,,,,,,,,,,,,,,,,H816 in KIT(D816H),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02402007,"[""Lysophospholipid (LPA) receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02402007,,,,,,,,,,,,,,,,,,,,,,,,,,,,Lysophospholipid (LPA) receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000907,"[""myometrium""]",,"The smooth muscle coat of the uterus, which forms the main mass of the organ.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001260,,,,,,,,"The smooth muscle coat of the uterus, which forms the main mass of the organ.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000907,,,,,,,BrendaTissueOBO,uterine smooth muscle|uterine myometrium,BTO:0000907,,,,,,,,,,,,,,,,,,,myometrium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001023,"[""ovary cancer cell""]",,A malignant tumor cell of the ovary.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A malignant tumor cell of the ovary.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001023,,,,,,,BrendaTissueOBO,ovarian cancer cell|ovarian carcinoma cell|ovary carcinoma cell,BTO:0001023,,,,,,,,,,,,,,,,,,,ovary cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217539,"[""NR1D2 gene""]",,"This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_00217463,,,,,,,,"This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217539,,,,,,,,,,,,,,,,9975,NR1D2,,,,,,,,,,,NR1D2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8541,"[""Sezary's disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060061,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8541,,,DOID:8790,SNOMEDCT_US_2016_03_01:4950009|ICD10CM:C84.10|SNOMEDCT_US_2016_03_01:188629004|UMLS_CUI:C0036920|ICD10CM:C84.1|ICD9CM:202.2|MESH:D012751|SNOMEDCT_US_2016_03_01:118611004|NCI:C3366|SNOMEDCT_US_2016_03_01:188638002,Sezary syndrome|Sezary disease,,disease_ontology,,DOID:8541,,,,,,,,,,,,,,,,,,,Sezary's disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400391,"[""CACNG subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400337,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400391,,,,,,,,,,,,,,,,,,,,,,,,,,,,CACNG subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050035,"[""African tick-bite fever""]",,"A spotted fever that has_material_basis_in Rickettsia africae, which is transmitted_by ticks (Amblyomma hebraeum and Amblyomma variegatum). The infection has_symptom fever, has_symptom eschar and has_symptom maculopapular rash.",false,,,http://purl.obolibrary.org/obo/DOID_11104,,,,,,,,"A spotted fever that has_material_basis_in Rickettsia africae, which is transmitted_by ticks (Amblyomma hebraeum and Amblyomma variegatum). The infection has_symptom fever, has_symptom eschar and has_symptom maculopapular rash.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050035,,,DOID:0050034|DOID:0050036,,Rickettsia africae spotted fever|south african tick-bite fever,,disease_ontology,,DOID:0050035,http://purl.obolibrary.org/obo/doid#tick-borne_infectious_disease|http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease|http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,African tick-bite fever,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050032,"[""mineral metabolism disease""]",,An acquired metabolic disease that is characterized by abnormal mineral metabolism.,false,,,http://purl.obolibrary.org/obo/DOID_0060158,,,,,,,,An acquired metabolic disease that is characterized by abnormal mineral metabolism.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050032,,,,,,,disease_ontology,,DOID:0050032,,,,,,,,,,,,,,,,,,,mineral metabolism disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300569,"[""KCa4.1/KCNT1 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300437,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300569,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCa4.1/KCNT1 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12574,"[""posterior uveitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_12030,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12574,,,,SNOMEDCT_US_2016_03_01:193451001|UMLS_CUI:C0042167|NCI:C35111|SNOMEDCT_US_2016_03_01:46627006|MESH:D015866|SNOMEDCT_US_2016_03_01:43363007,"Uveitis, posterior",,disease_ontology,,DOID:12574,,,,,,,,,,,,,,,,,,,posterior uveitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12571,"[""phacogenic glaucoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1686,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12571,,,,SNOMEDCT_US_2016_03_01:84333006|ICD9CM:365.59|UMLS_CUI:C0154959,,,disease_ontology,,DOID:12571,,,,,,,,,,,,,,,,,,,phacogenic glaucoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12577,"[""urethral obstruction""]",,,false,,,http://purl.obolibrary.org/obo/DOID_732,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12577,,,,NCI:C79804|SNOMEDCT_US_2016_03_01:95588004|UMLS_CUI:C0041972|MESH:D014524,Obstruction of urethra (disorder),,disease_ontology,,DOID:12577,,,,,,,,,,,,,,,,,,,urethral obstruction,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12570,"[""phacolytic glaucoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_12571,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12570,,,,SNOMEDCT_US_2016_03_01:32893002|UMLS_CUI:C0152137|ICD9CM:365.51,,,disease_ontology,,DOID:12570,,,,,,,,,,,,,,,,,,,phacolytic glaucoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400482,"[""STrpC subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400360,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400482,,,,,,,,,,,,,,,,,,,,,,,,,,,,STrpC subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200184,"[""ILK gene""]",,"This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400274,,,,,,,,"This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200184,,,,,,,,,,,,,,,,3611,ILK,ILK1|ILK2,,,,,,,,,,ILK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000376,"[""RET kinase domain""]",,Proto-oncogene tyrosine-protein kinase receptor Ret; CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET; RET51; RET-ELE1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Proto-oncogene tyrosine-protein kinase receptor Ret; CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET; RET51; RET-ELE1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000376,,,,,,,,,,,,,,,,,,,200370,,,,,,,,,RET kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300590,"[""TRPV1 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300484,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300590,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPV1 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000759,"[""liver""]",,1: A large very vascular glandular organ of vertebrates that secretes bile and causes important changes in many of the substances contained in the blood (as by converting sugars into glycogen which it stores up until required and by forming urea). 2: Any of various large compound glands associated with the digestive tract of invertebrate animals and probably concerned with the secretion of digestive enzymes.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000345|http://purl.obolibrary.org/obo/BTO_0001491|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,,1: A large very vascular glandular organ of vertebrates that secretes bile and causes important changes in many of the substances contained in the blood (as by converting sugars into glycogen which it stores up until required and by forming urea). 2: Any of various large compound glands associated with the digestive tract of invertebrate animals and probably concerned with the secretion of digestive enzymes.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000759,,,,,,,BrendaTissueOBO,,BTO:0000759,,,,,,,,,,,,,,,,,,,liver,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001829,"[""choroid""]",,The dark-brown vascular coat of the eye between the sclera and the retina.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The dark-brown vascular coat of the eye between the sclera and the retina.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001829,,,,,,,BrendaTissueOBO,choroid coat|chorioid|choroid membrane,BTO:0001829,,,,,,,,,,,,,,,,,,,choroid,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005736,"[""Hepa-RG cell""]",,Terminally differentiated hepatic cells derived from a human hepatic progenitor cell line that retains many characteristics of primary human hepatocytes.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000224,,,,,,,,Terminally differentiated hepatic cells derived from a human hepatic progenitor cell line that retains many characteristics of primary human hepatocytes.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005736,Marion,2015-04-27T10:07:58Z,,,,,BrendaTissueOBO,HepaRG cell,BTO:0005736,,,,,,,,,,,,,,,,,,,Hepa-RG cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100232,"[""Potassium voltage-gated channel subfamily kqt member 1""]",,"A voltage-gated potassium channel subunit KCNQ1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P51787] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300561,,,,,,,,"A voltage-gated potassium channel subunit KCNQ1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P51787] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100232,,,,https://pharos.nih.gov/idg/targets/P51787,,,,,,,,,,,,,KCNQ1,KCNA8|KCNA9|KVLQT1,,P51787,,,,,,,,Potassium voltage-gated channel subfamily kqt member 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13515,"[""tuberous sclerosis""]",,OMIM mapping confirmed by DO. [LS].,false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13515,,,,SNOMEDCT_US_2016_03_01:7199000|UMLS_CUI:C0041341|OMIM:191100|SNOMEDCT_US_2016_03_01:157027006|NCI:C3424|SNOMEDCT_US_2016_03_01:157033002|OMIM:613254|MESH:D014402|ICD10CM:Q85.1|ICD9CM:759.5|SNOMEDCT_US_2016_03_01:268359006,Tuberous sclerosis|Tuberose sclerosis|Epiloia|Tuberous sclerosis syndrome (disorder)|Bourneville's disease|cerebral sclerosis,,disease_ontology,,DOID:13515,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,tuberous sclerosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300298,"[""NinaC subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300187,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300298,,,,,,,,,,,,,,,,,,,,,,,,,,,,NinaC subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100397,"[""Olfactory receptor 51g2""]",,"An olfactory receptor 51G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 51G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100397,,,,https://pharos.nih.gov/idg/targets/Q8NGK0,,,,,,,,,,,,,OR51G2,,,Q8NGK0,,,,,,,,Olfactory receptor 51g2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200824,"[""VN1R5 gene""]",,"A vomeronasal type-1 receptor 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z5H4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400016,,,,,,,,"A vomeronasal type-1 receptor 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z5H4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200824,,,,,,,,,,,,,,,,317705,VN1R5,V1RL5,,,,,,,,,,VN1R5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200619,"[""OR5D13 gene""]",,"An olfactory receptor 5D13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5D13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200619,,,,,,,,,,,,,,,,390142,OR5D13,,,,,,,,,,,OR5D13 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400232,"[""TBCK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400232,,,,,,,,,,,,,,,,,,,,,,,,,,,,TBCK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12072,"[""pylorospasm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_76,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12072,,,,UMLS_CUI:C0152163|ICD9CM:537.81|SNOMEDCT_US_2016_03_01:335002,,,disease_ontology,,DOID:12072,,,,,,,,,,,,,,,,,,,pylorospasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400399,"[""ClC-5/CLCN5 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400341,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400399,,,,,,,,,,,,,,,,,,,,,,,,,,,,ClC-5/CLCN5 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000104,"[""MET109 in MK12""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000104,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET109 in MK12,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200233,"[""KCNQ2 gene""]",,"The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability.  The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400562,,,,,,,,"The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability.  The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200233,,,,,,,,,,,,,,,,3785,KCNQ2,,,,,,,,,,,KCNQ2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4378,"[""peanut allergy""]",,A food allergy that is an allergy or hypersensitivity to dietary substances from peanuts causing an overreaction of the immune system which in a small percentage of people may lead to severe physical symptoms.,false,,,http://purl.obolibrary.org/obo/DOID_4379,,,,,,,,A food allergy that is an allergy or hypersensitivity to dietary substances from peanuts causing an overreaction of the immune system which in a small percentage of people may lead to severe physical symptoms.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4378,,,,UMLS_CUI:C0559470|SNOMEDCT_US_2016_03_01:91935009|MESH:D021183|SNOMEDCT_US_2016_03_01:213021008,allergy to peanuts|peanut allergic reaction,,disease_ontology,,DOID:4378,,,,,,,,,,,,,,,,,,,peanut allergy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100496,"[""Serine/threonine-protein kinase stk11""]",,"A serine/threonine-protein kinase STK11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15831] |serine/threonine-protein kinase stk11 (LKB1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300316,,,,,,,,"A serine/threonine-protein kinase STK11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15831] |serine/threonine-protein kinase stk11 (LKB1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100496,,,,https://pharos.nih.gov/idg/targets/Q15831,,,,,,,,,,,,,STK11,LKB1|PJS,,Q15831,,,,,,,,Serine/threonine-protein kinase stk11,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001611,"[""SW-1736 cell""]",,Cell line derived from anaplastic thyroid carcinoma.,false,,,http://purl.obolibrary.org/obo/BTO_0003209|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Cell line derived from anaplastic thyroid carcinoma.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001611,,,,,,,BrendaTissueOBO,SW1736 cell,BTO:0001611,,,,,,,,,,,,,,,,,,,SW-1736 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300207,"[""PIM family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300207,,,,,,,,,,,,,,,,,,,,,,,,,,,,PIM family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300003,"[""Class B secretin like""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300001,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300003,,,,,,,,,,,,,,,,,,,,,,,,,,,,Class B secretin like,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200529,"[""OR2I1P gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200529,,,,,,,,,,,,,,,,442197,OR2I1P,OR2I2|OR2I3P|OR2I4P,,,,,,,,,,OR2I1P gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200005,"[""PRKAA2 gene""]",,"The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400245,,,,,,,,"The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200005,,,,,,,,,,,,,,,,5563,PRKAA2,AMPK|AMPK2,,,,,,,,,,PRKAA2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001639,"[""bud""]",,Any small part of the embryo or adult metazoon more or less resembling the bud of a plant and presumed to have potential for growth and differentiation.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Any small part of the embryo or adult metazoon more or less resembling the bud of a plant and presumed to have potential for growth and differentiation.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001639,,,,,,,BrendaTissueOBO,,BTO:0001639,,,,,,,,,,,,,,,,,,,bud,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200061,"[""CDK15 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400256,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200061,,,,,,,,,,,,,,,,65061,CDK15,ALS2CR7|PFTK2,,,,,,,,,,CDK15 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100094,"[""Cation channel sperm-associated protein 2""]",,"A cation channel sperm-associated protein 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q96P56] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300345,,,,,,,,"A cation channel sperm-associated protein 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q96P56] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100094,,,,https://pharos.nih.gov/idg/targets/Q96P56,,,,,,,,,,,,,CATSPER2,,,Q96P56,,,,,,,,Cation channel sperm-associated protein 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2218,"[""blood platelet disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2213,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2218,,,,MESH:D001791|SNOMEDCT_US_2016_03_01:22716005|UMLS_CUI:C0005818,platelet disorder|Thrombocytopathy,,disease_ontology,,DOID:2218,,,,,,,,,,,,,,,,,,,blood platelet disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000039,"[""ALK(C1156Y) kinase domain""]",,Anaplastic lymphoma receptor tyrosine kinase; ALK; CD246; NBLST3; TFG/ALK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Anaplastic lymphoma receptor tyrosine kinase; ALK; CD246; NBLST3; TFG/ALK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000039,,,,,,,,,,,,,,,,,,,200479,,,,,,,,,ALK(C1156Y) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001914,"[""colorectal adenocarcinoma cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0000167|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001616,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001914,,,,,,,BrendaTissueOBO,,BTO:0001914,,,,,,,,,,,,,,,,,,,colorectal adenocarcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002627,"[""T-lymphoblastoma cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000774,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002627,,,,,,,BrendaTissueOBO,,BTO:0002627,,,,,,,,,,,,,,,,,,,T-lymphoblastoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100388,"[""Serine/threonine-protein kinase pak 6""]",,"A serine/threonine-protein kinase PAK 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NQU5] |serine/threonine-protein kinase pak 6 (PAK6)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300304,,,,,,,,"A serine/threonine-protein kinase PAK 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NQU5] |serine/threonine-protein kinase pak 6 (PAK6)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100388,,,,https://pharos.nih.gov/idg/targets/Q9NQU5,,,,,,,,,,,,,PAK6,PAK5,,Q9NQU5,,,,,,,,Serine/threonine-protein kinase pak 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400250,"[""BARK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400127,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400250,,,,,,,,,,,,,,,,,,,,,,,,,,,,BARK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2349,"[""arteriosclerosis""]",,An artery disease that is characterized by a thickening and hardening of arterial walls in the arteries.,false,,,http://purl.obolibrary.org/obo/DOID_0050828,,,,,,,,An artery disease that is characterized by a thickening and hardening of arterial walls in the arteries.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2349,,,,UMLS_CUI:C0003850|SNOMEDCT_US_2016_03_01:28960008|SNOMEDCT_US_2016_03_01:155418003|SNOMEDCT_US_2016_03_01:195257001|SNOMEDCT_US_2016_03_01:195251000|CSP:0571-2299|SNOMEDCT_US_2016_03_01:72092001|MESH:D001161|NCI:C34398|ICD10CM:I70|SNOMEDCT_US_2016_03_01:107671003|SNOMEDCT_US_2016_03_01:155414001|SNOMEDCT_US_2016_03_01:266318005,Arteriosclerotic vascular disease NOS|Arteriosclerotic vascular disease (disorder)|Arteriosclerosis NOS|Arteriosclerosis (morphologic abnormality),,disease_ontology,,DOID:2349,,,,,,,,,,,,,,,,,,,arteriosclerosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000197,"[""MET734 in RIPK5""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000197,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET734 in RIPK5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3765,"[""pseudohermaphroditism""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1923,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3765,,,DOID:11226,ICD9CM:752.7|UMLS_CUI:C0021193|SNOMEDCT_US_2016_03_01:204897001|UMLS_CUI:C0033804|ICD10CM:Q56|MESH:D012734|SNOMEDCT_US_2016_03_01:268328009|ICD10CM:Q56.3|SNOMEDCT_US_2016_03_01:75164001|SNOMEDCT_US_2016_03_01:268229003|SNOMEDCT_US_2016_03_01:204895009,Indeterminate sex and pseudohermaphroditism,,disease_ontology,,DOID:3765,,,,,,,,,,,,,,,,,,,pseudohermaphroditism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000787,"[""gastric cancer cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0001088|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000787,,,,,,,BrendaTissueOBO,,BTO:0000787,,,,,,,,,,,,,,,,,,,gastric cancer cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100040,"[""Voltage-dependent L-type calcium channel subunit alpha-1C""]",,"A voltage-dependent L-type calcium channel subunit alpha-1C that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13936] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300383,,,,,,,,"A voltage-dependent L-type calcium channel subunit alpha-1C that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13936] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100040,,,,https://pharos.nih.gov/idg/targets/Q13936,,,,,,,,,,,,,CACNA1C,CACH2|CACN2|CACNL1A1|CCHL1A1,,Q13936,,,,,,,,Voltage-dependent L-type calcium channel subunit alpha-1C,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200474,"[""STKLD1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400225,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200474,,,,,,,,,,,,,,,,169436,STKLD1,C9orf96|SGK071,,,,,,,,,,STKLD1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100564,"[""Putative olfactory receptor 3a4""]",,"An olfactory receptor 3A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47883] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 3A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47883] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100564,,,,https://pharos.nih.gov/idg/targets/P47883,,,,,,,,,,,,,OR3A4P,OR3A4|OR3A5P,,P47883,,,,,,,,Putative olfactory receptor 3a4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200281,"[""PKDREJ gene""]",,"This intronless gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a receptor for egg jelly (REJ) domain, a G-protein-coupled receptor proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may play a role in human reproduction. Alternative splice variants have been described but their biological natures have not been determined. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400367,,,,,,,,"This intronless gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a receptor for egg jelly (REJ) domain, a G-protein-coupled receptor proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may play a role in human reproduction. Alternative splice variants have been described but their biological natures have not been determined. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200281,,,,,,,,,,,,,,,,10343,PKDREJ,,,,,,,,,,,PKDREJ gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100463,"[""Tyrosine-protein kinase ryk""]",,"A tyrosine-protein kinase RYK that is encoded in the genome of human. [PRO:DNx, UniProtKB:P34925] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300221,,,,,,,,"A tyrosine-protein kinase RYK that is encoded in the genome of human. [PRO:DNx, UniProtKB:P34925] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100463,,,,https://pharos.nih.gov/idg/targets/P34925,,,,,,,,,,,,,RYK,JTK5A,,P34925,,,,,,,,Tyrosine-protein kinase ryk,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050148,"[""laryngotracheitis""]",,An upper respiratory tract disease involving inflammation of both larynx and trachea often caused by viral infection. The infection can close off the windpipe.,false,,,http://purl.obolibrary.org/obo/DOID_974,,,,,,,,An upper respiratory tract disease involving inflammation of both larynx and trachea often caused by viral infection. The infection can close off the windpipe.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050148,,,DOID:11795|DOID:9390,SNOMEDCT_US_2016_03_01:195697006|UMLS_CUI:C0155811|SNOMEDCT_US_2016_03_01:64375000|SNOMEDCT_US_2016_03_01:155508005|UMLS_CUI:C0155837|SNOMEDCT_US_2016_03_01:195694004|ICD9CM:464.2|SNOMEDCT_US_2016_03_01:83271005|ICD9CM:464|SNOMEDCT_US_2016_03_01:195679003|SNOMEDCT_US_2016_03_01:276443001|ICD10CM:J04|ICD9CM:476.1|SNOMEDCT_US_2016_03_01:195703007|SNOMEDCT_US_2016_03_01:155505008|ICD10CM:J04.2|ICD10CM:J37.1,,,disease_ontology,,DOID:0050148,,,,,,,,,,,,,,,,,,,laryngotracheitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200302,"[""SCN11A gene""]",,"Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.[supplied by OMIM, Apr 2004]",false,,,http://www.drugtargetontology.org/dto/DTO_01400476,,,,,,,,"Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.[supplied by OMIM, Apr 2004]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200302,,,,,,,,,,,,,,,,11280,SCN11A,SCN12A|SNS2,,,,,,,,,,SCN11A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200166,"[""GUCY2C gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400125,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200166,,,,,,,,,,,,,,,,2984,GUCY2C,GUC2C|STAR,,,,,,,,,,GUCY2C gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004057,"[""fruit juice""]",,Juice produced by squeezing or crushing fruit.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000659,,,,,,,,Juice produced by squeezing or crushing fruit.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004057,,,,,,,BrendaTissueOBO,,BTO:0004057,,,,,,,,,,,,,,,,,,,fruit juice,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5425,"[""ovarian hyperstimulation syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_1100,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5425,,,,MESH:D016471|SNOMEDCT_US_2016_03_01:129635004|UMLS_CUI:C0085083|OMIM:608115,secondary Meig's syndrome,,disease_ontology,,DOID:5425,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,ovarian hyperstimulation syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200103,"[""FXYD5 gene""]",,"This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400349,,,,,,,,"This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200103,,,,,,,,,,,,,,,,53827,FXYD5,DYSAD|IWU1,,,,,,,,,,FXYD5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000286,"[""cornea""]",,The transparent part of the coat of the eyeball that covers the iris and pupil and admits light to the interior.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The transparent part of the coat of the eyeball that covers the iris and pupil and admits light to the interior.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000286,,,,,,,BrendaTissueOBO,,BTO:0000286,,,,,,,,,,,,,,,,,,,cornea,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000614,"[""PTH""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000614,,,,,,,,,,,,,,,,,,,,,,,,,,,,PTH,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000027,"[""LEU106 in MYO3B""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000027,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU106 in MYO3B,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300234,"[""TIE family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300234,,,,,,,,,,,,,,,,,,,,,,,,,,,,TIE family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100244,"[""Protein kinase c iota type""]",,"A protein kinase C iota type that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41743] |protein kinase c iota type (KPCI)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300279,,,,,,,,"A protein kinase C iota type that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41743] |protein kinase c iota type (KPCI)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100244,,,,https://pharos.nih.gov/idg/targets/P41743,,,,,,,,,,,,,PRKCI,DXS1179E,,P41743,,,,,,,,Protein kinase c iota type,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200597,"[""OR4K17 gene""]",,"An olfactory receptor 4K17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4K17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200597,,,,,,,,,,,,,,,,390436,OR4K17,,,,,,,,,,,OR4K17 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003204,"[""Caki-1 cell""]",,"Human renal cancer cell line, established from a 49-years-old male.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000383,,,,,,,,"Human renal cancer cell line, established from a 49-years-old male.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003204,,,,,,,BrendaTissueOBO,,BTO:0003204,,,,,,,,,,,,,,,,,,,Caki-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100409,"[""Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha""]",,"A phosphatidylinositol 5-phosphate 4-kinase type-2 alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48426] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300323,,,,,,,,"A phosphatidylinositol 5-phosphate 4-kinase type-2 alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48426] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100409,,,,https://pharos.nih.gov/idg/targets/P48426,,,,,,,,,,,,,PIP4K2A,PIP5K2|PIP5K2A,,P48426,,,,,,,,Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_552,"[""pneumonia""]",,"A lung disease that involves lung parenchyma or alveolar inflammation and abnormal alveolar filling with fluid (consolidation and exudation). It results from a variety of causes including infection with bacteria, viruses, fungi or parasites, and chemical or physical injury to the lungs. It is accompanied by fever, chills, cough, and difficulty in breathing.",false,,,http://purl.obolibrary.org/obo/DOID_850,,,,,,,,"A lung disease that involves lung parenchyma or alveolar inflammation and abnormal alveolar filling with fluid (consolidation and exudation). It results from a variety of causes including infection with bacteria, viruses, fungi or parasites, and chemical or physical injury to the lungs. It is accompanied by fever, chills, cough, and difficulty in breathing.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:552,,,DOID:5871|DOID:10509|DOID:11742,SNOMEDCT_US_2016_03_01:274103002|SNOMEDCT_US_2016_03_01:155552002|SNOMEDCT_US_2016_03_01:60363000|UMLS_CUI:C0032285|NCI:C3333|SNOMEDCT_US_2016_03_01:155548002|SNOMEDCT_US_2016_03_01:155558003|SNOMEDCT_US_2016_03_01:266391003|SNOMEDCT_US_2016_03_01:233604007|MESH:D011014,acute pneumonia,,disease_ontology,,DOID:552,,,,,,,,,,,,,,,,,,,pneumonia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_557,"[""kidney disease""]",,A urinary system disease that is located_in the kidney.,false,,,http://purl.obolibrary.org/obo/DOID_18,,,,,,,,A urinary system disease that is located_in the kidney.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:557,,,,SNOMEDCT_US_2016_03_01:266624005|NCI:C34843|NCI:C3149|ICD10CM:N08|SNOMEDCT_US_2016_03_01:155871008|UMLS_CUI:C0022658|ICD10CM:N28.9|SNOMEDCT_US_2016_03_01:274108006|SNOMEDCT_US_2016_03_01:266627003|SNOMEDCT_US_2016_03_01:266612003|EFO:0003086|MESH:D007674|SNOMEDCT_US_2016_03_01:90708001,nephropathy,,disease_ontology,,DOID:557,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,kidney disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000879,"[""lateral ventricle""]",,"An internal cavity in each cerebral hemisphere that consists of a central body and three cornua including an anterior one curving forward and outward, a posterior one curving backward, and an inferior one curving downward.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"An internal cavity in each cerebral hemisphere that consists of a central body and three cornua including an anterior one curving forward and outward, a posterior one curving backward, and an inferior one curving downward.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000879,,,,,,,BrendaTissueOBO,lateral ventricle of brain,BTO:0000879,,,,,,,,,,,,,,,,,,,lateral ventricle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000051,"[""LEU137 in ERK5""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000051,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU137 in ERK5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9335,"[""scotoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5614,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9335,,,DOID:9482|DOID:10751|DOID:10750,ICD9CM:368.45|SNOMEDCT_US_2016_03_01:33970004|ICD10CM:H53.42|UMLS_CUI:C0155012|UMLS_CUI:C0152192|ICD10CM:H53.45|ICD9CM:368.44|ICD10CM:H53.43|UMLS_CUI:C0155011|UMLS_CUI:C0029657|ICD9CM:368.42|ICD9CM:368.43|SNOMEDCT_US_2016_03_01:193673000,Enlarged paracaecal scotoma|Enlarged angioscotoma|Sector or arcuate visual field defects|Generalized visual field contraction or constriction|Scotoma of blind spot area|Enlarged blind spot|Blind spot area scotoma,,disease_ontology,,DOID:9335,,,,,,,,,,,,,,,,,,,scotoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100612,"[""Olfactory receptor 5a2""]",,"An olfactory receptor 5A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100612,,,,https://pharos.nih.gov/idg/targets/Q8NGI9,,,,,,,,,,,,,OR5A2,,,Q8NGI9,,,,,,,,Olfactory receptor 5a2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200711,"[""OR9A1P gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200711,,,,,,,,,,,,,,,,26495,OR9A1P,OR9A1,,,,,,,,,,OR9A1P gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9847,"[""peripheral vertigo""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3426,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9847,,,,ICD9CM:386.1|UMLS_CUI:C0029706|SNOMEDCT_US_2016_03_01:194353007|SNOMEDCT_US_2016_03_01:194692006|ICD10CM:H81.3|SNOMEDCT_US_2016_03_01:194359006|ICD9CM:386.19|ICD10CM:H81.399|ICD10CM:H81.39,,,disease_ontology,,DOID:9847,,,,,,,,,,,,,,,,,,,peripheral vertigo,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9409,"[""diabetes insipidus""]",,,false,,,http://purl.obolibrary.org/obo/DOID_557,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9409,,,,ICD10CM:E23.2|ICD9CM:253.5|MESH:D003919|SNOMEDCT_US_2016_03_01:15771004|SNOMEDCT_US_2016_03_01:190484000|NCI:C43263|UMLS_CUI:C0011848,,,disease_ontology,,DOID:9409,,,,,,,,,,,,,,,,,,,diabetes insipidus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200205,"[""GPR63 gene""]",,"A G-protein coupled receptor 63 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BZJ6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 63 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BZJ6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200205,,,,,,,,,,,,,,,,81491,GPR63,PSP24B,,,,,,,,,,GPR63 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200184,"[""KCNA5 gene""]",,"Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7). [provided by RefSeq, May 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400536,,,,,,,,"Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7). [provided by RefSeq, May 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200184,,,,,,,,,,,,,,,,3741,KCNA5,,,,,,,,,,,KCNA5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050515,"[""paralytic poliomyelitis""]",,"A poliomyelitis that results_in destruction located_in motor neurons of central nervous system, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom loss of reflexes, has_symptom muscle spasms, and has_symptom acute flaccid paralysis.",false,,,http://purl.obolibrary.org/obo/DOID_4953,,,,,,,,"A poliomyelitis that results_in destruction located_in motor neurons of central nervous system, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom loss of reflexes, has_symptom muscle spasms, and has_symptom acute flaccid paralysis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050515,,,,,,,disease_ontology,,DOID:0050515,,,,,,,,,,,,,,,,,,,paralytic poliomyelitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002417,"[""helper T-lymphocyte""]",,"A T-cell that participates in an immune response by recognizing a foreign antigen and secreting lymphokines to activate T cell and B cell proliferation, that usually carries CD4 molecular markers on its cell surface, and that is reduced to 20 percent or less of normal numbers in AIDS.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000782,,,,,,,,"A T-cell that participates in an immune response by recognizing a foreign antigen and secreting lymphokines to activate T cell and B cell proliferation, that usually carries CD4 molecular markers on its cell surface, and that is reduced to 20 percent or less of normal numbers in AIDS.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002417,Marion,2010-01-28T08:36:32Z,,,,,BrendaTissueOBO,T helper cell|helper lymphocyte|helper T lymphocyte|helper cell|T4 cell|CD4 cell|helper T-cell|helper T cell,BTO:0002417,,,,,,,,,,,,,,,,,,,helper T-lymphocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3151,"[""skin squamous cell carcinoma""]",,A skin carcinoma that has_material_basis_in squamous cells.,false,,,http://purl.obolibrary.org/obo/DOID_1749|http://purl.obolibrary.org/obo/DOID_3451,,,,,,,,A skin carcinoma that has_material_basis_in squamous cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3151,,,,SNOMEDCT_US_2016_03_01:254651007|NCI:C4819|UMLS_CUI:C0553723,Epidermoid skin carcinoma,,disease_ontology,squamous cell carcinoma of skin,DOID:3151,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,skin squamous cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00500646,"[""Ligand-gated""]",,"""Ligand-gated"" is used in context to certain ion channel proteins. Ligand-gated ion channels (LICs, LGIC), also commonly referred as ionotropic receptors, are a group of transmembrane ion channel proteins which open to allow ions such as Na+, K+, Ca2+, and/or Cl? to pass through the membrane in response to the binding of a chemical messenger (i.e. a ligand), such as a neurotransmitter.",false,,,http://www.drugtargetontology.org/dto/DTO_00500669,,,,,,,,"""Ligand-gated"" is used in context to certain ion channel proteins. Ligand-gated ion channels (LICs, LGIC), also commonly referred as ionotropic receptors, are a group of transmembrane ion channel proteins which open to allow ions such as Na+, K+, Ca2+, and/or Cl? to pass through the membrane in response to the binding of a chemical messenger (i.e. a ligand), such as a neurotransmitter.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00500646,,,,,,,,,,,,,,,,,,,,,,,,,,,,Ligand-gated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001022,"[""periosteum""]",,The dense fibrous membrane covering the surface of bones except at the joints and serving as an attachment for muscles and tendons.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The dense fibrous membrane covering the surface of bones except at the joints and serving as an attachment for muscles and tendons.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001022,,,,,,,BrendaTissueOBO,,BTO:0001022,,,,,,,,,,,,,,,,,,,periosteum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000192,"[""nasopharyngeal carcinoma cell""]",,A cell of a disease in which cancer (malignant) cells are found in the tissues of the nasopharynx.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000176,,,,,,,,A cell of a disease in which cancer (malignant) cells are found in the tissues of the nasopharynx.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000192,,,,,,,BrendaTissueOBO,"nasopharynx carcinoma cell|nasopharynx cancer cell|carcinoma cell, nasopharynx|nasopharyngeal cancer cell",BTO:0000192,,,,,,,,,,,,,,,,,,,nasopharyngeal carcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400403,"[""CNGA2 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400343,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400403,,,,,,,,,,,,,,,,,,,,,,,,,,,,CNGA2 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300111,"[""CMGC group""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300102,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300111,,,,,,,,,,,,,,,,,,,,,,,,,,,,CMGC group,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005288,"[""CL-48 cell""]",,Normal human fetal liver cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001242|http://purl.obolibrary.org/obo/BTO_0000224,,,,,,,,Normal human fetal liver cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005288,XPMUser,2012-02-08T08:54:24Z,,,,,BrendaTissueOBO,,BTO:0005288,,,,,,,,,,,,,,,,,,,CL-48 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100716,"[""Olfactory receptor 9g9""]",,"An olfactory receptor 9G9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7N8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 9G9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7N8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100716,,,,https://pharos.nih.gov/idg/targets/P0C7N8,,,,,,,,,,,,,OR9G9,,,P0C7N8,,,,,,,,Olfactory receptor 9g9,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200692,"[""OR8D2 gene""]",,"An olfactory receptor 8D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZM6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 8D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZM6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200692,,,,,,,,,,,,,,,,283160,OR8D2,,,,,,,,,,,OR8D2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100608,"[""Nucleoside diphosphate kinase B""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100608,,,,,,,,,,,,,,,,,NME1-NME2,,,P22392,,,,,,,,Nucleoside diphosphate kinase B,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000063,"[""LEU173 in SGK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000063,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU173 in SGK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100072,"[""Chloride channel protein 1""]",,"A chloride channel protein, skeletal muscle that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35523] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300395,,,,,,,,"A chloride channel protein, skeletal muscle that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35523] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100072,,,,https://pharos.nih.gov/idg/targets/P35523,,,,,,,,,,,,,CLCN1,CLC1,,P35523,,,,,,,,Chloride channel protein 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400135,"[""CAMK-UNIQUE family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400135,,,,,,,,,,,,,,,,,,,,,,,,,,,,CAMK-UNIQUE family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200425,"[""PIK3CG gene""]",,"This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03491009,,,,,,,,"This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200425,,,,,,,,,,,,,,,,5294,PIK3CG,,,,,,,,,,,PIK3CG gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00000015,"[""nucleoside GPCR ligand""]",,A GPCR ligand that is classified as nucleoside in CHEBI.,false,,,http://purl.obolibrary.org/obo/CHEBI_33838|http://www.drugtargetontology.org/dto/DTO_00000001,,,,,,,,A GPCR ligand that is classified as nucleoside in CHEBI.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00000015,,,,,,,,,,,,,,,,,,,,,,,,,,,Asiyah Yu Lin,nucleoside GPCR ligand,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001164,"[""megakaryoblast""]",,"The earliest cytologically identifiable precursor in the thrombocytic series, a large cell that matures to form a promegakaryocyte.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The earliest cytologically identifiable precursor in the thrombocytic series, a large cell that matures to form a promegakaryocyte.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001164,,,,,,,BrendaTissueOBO,megacaryoblast,BTO:0001164,,,,,,,,,,,,,,,,,,,megakaryoblast,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000247,"[""shoot tip""]",,"The terminal bud (0.1 - 1.0 mm) of a plant, which consists of the apical meristem (0.05 - 0.1 mm) and the immediate surrounding leaf primordia and developing leaves and adjacent stem tissue.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The terminal bud (0.1 - 1.0 mm) of a plant, which consists of the apical meristem (0.05 - 0.1 mm) and the immediate surrounding leaf primordia and developing leaves and adjacent stem tissue.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000247,,,,,,,BrendaTissueOBO,shoot apex,BTO:0000247,,,,,,,,,,,,,,,,,,,shoot tip,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_970,"[""tenosynovitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_381|http://purl.obolibrary.org/obo/DOID_971,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:970,,,,SNOMEDCT_US_2016_03_01:268092005|MESH:D013717|SNOMEDCT_US_2016_03_01:67801009|SNOMEDCT_US_2016_03_01:156666009|SNOMEDCT_US_2016_03_01:240035004|UMLS_CUI:C0039520,Inflammation of tendon sheath,,disease_ontology,,DOID:970,,,,,,,,,,,,,,,,,,,tenosynovitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_971,"[""tendinitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_633,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:971,,,,SNOMEDCT_US_2016_03_01:34840004|SNOMEDCT_US_2016_03_01:312785002|NCI:C97141|SNOMEDCT_US_2016_03_01:156665008|MESH:D052256|SNOMEDCT_US_2016_03_01:267996008|SNOMEDCT_US_2016_03_01:202893001|SNOMEDCT_US_2016_03_01:268091003|ICD10CM:M77.9|UMLS_CUI:C0039503,,,disease_ontology,,DOID:971,,,,,,,,,,,,,,,,,,,tendinitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_974,"[""upper respiratory tract disease""]",,A respiratory system disease which involves the upper respiratory tract.,false,,,http://purl.obolibrary.org/obo/DOID_1579,,,,,,,,A respiratory system disease which involves the upper respiratory tract.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:974,,,,SNOMEDCT_US_2016_03_01:195823002|ICD9CM:478.19|UMLS_CUI:C0029581|SNOMEDCT_US_2016_03_01:266346007|ICD9CM:478.1,,,disease_ontology,,DOID:974,,,,,,,,,,,,,,,,,,,upper respiratory tract disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400154,"[""IRE family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400154,,,,,,,,,,,,,,,,,,,,,,,,,,,,IRE family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100138,"[""G-protein coupled receptor 124""]",,"A G-protein coupled receptor 124 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96PE1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,"A G-protein coupled receptor 124 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96PE1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100138,,,,https://pharos.nih.gov/idg/targets/Q96PE1,,,,,,,,,,,,,GPR124,ADGRA2|KIAA1531|TEM5,,Q96PE1,,,,,,,,G-protein coupled receptor 124,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_7459,"[""acantholytic variant squamous cell breast carcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5514,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:7459,,,,NCI:C40359|UMLS_CUI:C1519485,,,disease_ontology,,DOID:7459,,,,,,,,,,,,,,,,,,,acantholytic variant squamous cell breast carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491041,"[""Unclassified protein gene""]",,A probable kinase protein that is not yet classified into either protein kinase or non-protein kinase.,false,,,http://www.drugtargetontology.org/dto/DTO_03400101,,,,,,,,A probable kinase protein that is not yet classified into either protein kinase or non-protein kinase.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,Unclassified protein gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200002,"[""HTR3B gene""]",,"The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. [provided by RefSeq, Aug 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01409932,,,,,,,,"The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. [provided by RefSeq, Aug 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200002,,,,,,,,,,,,,,,,9177,HTR3B,,,,,,,,,,,HTR3B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_682,"[""compartment syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_326,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:682,,,,SNOMEDCT_US_2016_03_01:45781009|MESH:D003161|SNOMEDCT_US_2016_03_01:212379008|ICD10CM:T79.A0|ICD9CM:958.90|SNOMEDCT_US_2016_03_01:111245009|UMLS_CUI:C0009492|NCI:C118422,"Compartmental syndrome, NOS|Compartment syndrome (disorder)|Compartment syndrome",,disease_ontology,,DOID:682,,,,,,,,,,,,,,,,,,,compartment syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_680,"[""tauopathy""]",,A neurodegenerative disease that has_material_basis_in the pathological aggregation of tau protein in so-called neurofibrillary tangles (NFT) in the human brain.,false,,,http://purl.obolibrary.org/obo/DOID_1289,,,,,,,,A neurodegenerative disease that has_material_basis_in the pathological aggregation of tau protein in so-called neurofibrillary tangles (NFT) in the human brain.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:680,,,,UMLS_CUI:C0949664|MESH:D024801,,,disease_ontology,,DOID:680,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,tauopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_686,"[""liver carcinoma""]",,A liver cancer that has_material_basis_in epithelial cells.,false,,,http://purl.obolibrary.org/obo/DOID_3571|http://purl.obolibrary.org/obo/DOID_305,,,,,,,,A liver cancer that has_material_basis_in epithelial cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:686,,,,UMLS_CUI:C0279000|NCI:C7927,Liver and Intrahepatic bile duct carcinoma,,disease_ontology,,DOID:686,,,,,,,,,,,,,,,,,,,liver carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_684,"[""hepatocellular carcinoma""]",,A liver carcinoma that has_material_basis_in undifferentiated hepatocytes.,false,,,http://purl.obolibrary.org/obo/DOID_686,,,,,,,,A liver carcinoma that has_material_basis_in undifferentiated hepatocytes.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:684,,,DOID:5005,OMIM:114550|EFO:0000182|UMLS_CUI:C0279607|NCI:C7711|NCI:C7956,adult primary hepatocellular carcinoma|Hepatoma|HCC|adult Hepatoma,,disease_ontology,,DOID:684,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,hepatocellular carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_687,"[""hepatoblastoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3571,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:687,,,,SNOMEDCT_US_2016_03_01:45024009|NCI:C3728|MESH:D018197|SNOMEDCT_US_2016_03_01:109843000|ICD10CM:C22.2|UMLS_CUI:C0206624,HBL,,disease_ontology,,DOID:687,,,,,,,,,,,,,,,,,,,hepatoblastoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1168,"[""familial hyperlipidemia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3146,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1168,,,DOID:3147,SNOMEDCT_US_2016_03_01:190782002|MESH:D006951|SNOMEDCT_US_2016_03_01:154739000|UMLS_CUI:C0020473|UMLS_CUI:C0020476|SNOMEDCT_US_2016_03_01:267499005|ICD10CM:E78.5|MESH:D006949|SNOMEDCT_US_2016_03_01:154743001|SNOMEDCT_US_2016_03_01:3744001|NCI:C34709|NCI:C34707|SNOMEDCT_US_2016_03_01:55822004,hyperlipemia|familial hyperlipoproteinemia,,disease_ontology,hyperlipidaemia,DOID:1168,,,,,,,,,,,,,,,,,,,familial hyperlipidemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100448,"[""Serine/threonine-protein kinase rio2""]",,"serine/threonine-protein kinase rio2 (RIOK2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase RIO2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BVS4] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300311,,,,,,,,"serine/threonine-protein kinase rio2 (RIOK2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase RIO2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BVS4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100448,,,,https://pharos.nih.gov/idg/targets/Q9BVS4,,,,,,,,,,,,,RIOK2,,,Q9BVS4,,,,,,,,Serine/threonine-protein kinase rio2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200203,"[""KCNG3 gene""]",,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400551,,,,,,,,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200203,,,,,,,,,,,,,,,,170850,KCNG3,,,,,,,,,,,KCNG3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200424,"[""PIK3CD gene""]",,"Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03491009,,,,,,,,"Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200424,,,,,,,,,,,,,,,,5293,PIK3CD,,,,,,,,,,,PIK3CD gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100458,"[""Olfactory receptor 6c68""]",,"An olfactory receptor 6C68 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NDL8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6C68 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NDL8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100458,,,,https://pharos.nih.gov/idg/targets/A6NDL8,,,,,,,,,,,,,OR6C68,,,A6NDL8,,,,,,,,Olfactory receptor 6c68,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300100,"[""P2Y receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300053,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300100,,,,,,,,,,,,,,,,,,,,,,,,,,,,P2Y receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003945,"[""MN-9D cell""]",,The MN9D murine dopaminergic cell line was generated by fusion of rostral mesencephalic neurons from embryonic C57BL/6J (embryonic day 14) mice with N18TG2 neuroblastoma cells.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The MN9D murine dopaminergic cell line was generated by fusion of rostral mesencephalic neurons from embryonic C57BL/6J (embryonic day 14) mice with N18TG2 neuroblastoma cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003945,,,,,,,BrendaTissueOBO,MN9D cell,BTO:0003945,,,,,,,,,,,,,,,,,,,MN-9D cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000373,"[""PRP4 kinase domain""]",,PRP4 pre-mRNA processing factor 4 homolog B (yeast); dJ1013A10.1; KIAA0536; PR4H; PRP4; PRP4H; PRP4K; PRPF4B,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,PRP4 pre-mRNA processing factor 4 homolog B (yeast); dJ1013A10.1; KIAA0536; PR4H; PRP4; PRP4H; PRP4K; PRPF4B,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000373,,,,,,,,,,,,,,,,,,,200366,,,,,,,,,PRP4 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000027,"[""ABL2 kinase domain""]",,"V-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene); ABL2; ABLL; ARG; FLJ22224; FLJ31718; FLJ41441",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"V-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene); ABL2; ABLL; ARG; FLJ22224; FLJ31718; FLJ41441",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000027,,,,,,,,,,,,,,,,,,,200026,,,,,,,,,ABL2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3275,"[""thymoma""]",,"A thymus cancer that derives_from epithelial cells located_in the thymus. The tumor cells in a thymoma look similar to the normal cells of the thymus, grow slowly, and rarely spread beyond the thymus.",false,,,http://purl.obolibrary.org/obo/DOID_3277,,,,,,,,"A thymus cancer that derives_from epithelial cells located_in the thymus. The tumor cells in a thymoma look similar to the normal cells of the thymus, grow slowly, and rarely spread beyond the thymus.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3275,,,,NCI:C3411|SNOMEDCT_US_2016_03_01:128856005|SNOMEDCT_US_2016_03_01:189721001|SNOMEDCT_US_2016_03_01:444231005|MESH:D013945|UMLS_CUI:C0040100,,,disease_ontology,,DOID:3275,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,thymoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002244,"[""flower stalk""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002244,,,,,,,BrendaTissueOBO,flower axis|flower stem,BTO:0002244,,,,,,,,,,,,,,,,,,,flower stalk,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000260,"[""PHE277 in HIPK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000260,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE277 in HIPK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100085,"[""Choline/ethanolamine kinase""]",,"A choline/ethanolamine kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y259] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391029,,,,,,,,"A choline/ethanolamine kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y259] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100085,,,,https://pharos.nih.gov/idg/targets/Q9Y259,,,,,,,,,,,,,CHKB,CHETK|CHKL,,Q9Y259,,,,,,,,Choline/ethanolamine kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100442,"[""Protein-tyrosine kinase 6""]",,"protein-tyrosine kinase 6 (PTK6)  with  no mutation  in a nonphosphorylated state|A protein-tyrosine kinase 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13882] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300132,,,,,,,,"protein-tyrosine kinase 6 (PTK6)  with  no mutation  in a nonphosphorylated state|A protein-tyrosine kinase 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13882] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100442,,,,https://pharos.nih.gov/idg/targets/Q13882,,,,,,,,,,,,,PTK6,BRK,,Q13882,,,,,,,,Protein-tyrosine kinase 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100789,"[""Taste receptor type 2 member 43""]",,"A taste receptor type 2 member 43 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59537] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300014,,,,,,,,"A taste receptor type 2 member 43 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59537] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100789,,,,https://pharos.nih.gov/idg/targets/P59537,,,,,,,,,,,,,TAS2R43,,,P59537,,,,,,,,Taste receptor type 2 member 43,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200429,"[""OR52M1 gene""]",,"An olfactory receptor 52M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 52M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200429,,,,,,,,,,,,,,,,119772,OR52M1,OR52M1P,,,,,,,,,,OR52M1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5426,"[""premature ovarian failure""]",,An ovarian disease where ovaries do not produce estrogen despite high levels of circulating gonadotropins in women under 40.,false,,,http://purl.obolibrary.org/obo/DOID_1100,,,,,,,,An ovarian disease where ovaries do not produce estrogen despite high levels of circulating gonadotropins in women under 40.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5426,,,,OMIM:300511|ORDO:619|OMIM:612964|SNOMEDCT_US_2016_03_01:65846009|OMIM:612310|OMIM:615724|OMIM:300510|OMIM:300604|OMIM:611548|OMIM:311360|OMIM:615723|ICD10CM:E28.3|UMLS_CUI:C0085215|NCI:C113352|MESH:D016649|SNOMEDCT_US_2016_03_01:190545008|SNOMEDCT_US_2016_03_01:237788002|OMIM:608996|SNOMEDCT_US_2016_03_01:39381003,hypergonadotropic hypogonadism|primary ovarian insufficiency|premature ovarian insufficiency|premature menopause,,disease_ontology,,DOID:5426,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,premature ovarian failure,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002008,"[""culture condition:antigen-presenting cell""]",,An antigen-presenting cell is a cell that displays foreign antigen complex with major histocompatibility complex on its surface.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000216,,,,,,,,An antigen-presenting cell is a cell that displays foreign antigen complex with major histocompatibility complex on its surface.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002008,,,,,,,BrendaTissueOBO,accessory cell|APC cell,BTO:0002008,,,,,,,,,,,,,,,,,,,culture condition:antigen-presenting cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100241,"[""Protein kinase c delta type""]",,"A protein kinase C delta type that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q05655] |protein kinase c delta type (KPCD)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300277,,,,,,,,"A protein kinase C delta type that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q05655] |protein kinase c delta type (KPCD)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100241,,,,https://pharos.nih.gov/idg/targets/Q05655,,,,,,,,,,,,,PRKCD,,,Q05655,,,,,,,,Protein kinase c delta type,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100274,"[""Neuromedin-U receptor 1""]",,"A neuromedin-U receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HB89] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300067,,,,,,,,"A neuromedin-U receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HB89] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100274,,,,https://pharos.nih.gov/idg/targets/Q9HB89,,,,,,,,,,,,,NMUR1,GPR66,,Q9HB89,,,,,,,,Neuromedin-U receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6823,"[""pancreatoblastoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4905,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6823,,,,NCI:C4265|SNOMEDCT_US_2016_03_01:53618008|UMLS_CUI:C0334489|SNOMEDCT_US_2016_03_01:189814006|MESH:C537162,Pancreatoblastoma (morphologic abnormality),,disease_ontology,,DOID:6823,,,,,,,,,,,,,,,,,,,pancreatoblastoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400027,"[""Anaphylatoxin receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400027,,,,,,,,,,,,,,,,,,,,,,,,,,,,Anaphylatoxin receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100493,"[""Olfactory receptor 1J2""]",,"An olfactory receptor 1J2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1J2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100493,,,,https://pharos.nih.gov/idg/targets/Q8NGS2,,,,,,,,,,,,,OR1J2,OR1J3|OR1J5,,Q8NGS2,,,,,,,,Olfactory receptor 1J2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002807,"[""prefrontal cortex""]",,"The prefrontal cortex is the anterior part of the frontal lobes of the brain, lying in front of the motor and premotor areas.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The prefrontal cortex is the anterior part of the frontal lobes of the brain, lying in front of the motor and premotor areas.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002807,,,,,,,BrendaTissueOBO,prefrontal association complex,BTO:0002807,,,,,,,,,,,,,,,,,,,prefrontal cortex,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000340,"[""THR315 in ABL1(Y253F)-phosphorylated""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000340,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR315 in ABL1(Y253F)-phosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400097,"[""C-X-C chemokine receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400031,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400097,,,,,,,,,,,,,,,,,,,,,,,,,,,,C-X-C chemokine receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100130,"[""Glycine receptor subunit beta""]",,"A glycine receptor subunit beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48167] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300529,,,,,,,,"A glycine receptor subunit beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48167] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100130,,,,https://pharos.nih.gov/idg/targets/P48167,,,,,,,,,,,,,GLRB,,,P48167,,,,,,,,Glycine receptor subunit beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100120,"[""Growth hormone secretagogue receptor type 1""]",,"A growth hormone secretagogue receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q92847] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300048,,,,,,,,"A growth hormone secretagogue receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q92847] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100120,,,,https://pharos.nih.gov/idg/targets/Q92847,,,,,,,,,,,,,GHSR,,,Q92847,,,,,,,,Growth hormone secretagogue receptor type 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300380,"[""Acid-sensing ion channel 5 (ASIC5) subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300330,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300380,,,,,,,,,,,,,,,,,,,,,,,,,,,,Acid-sensing ion channel 5 (ASIC5) subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001042,"[""amygdala""]",,The one of the four basal ganglia in each cerebral hemisphere that is part of the limbic system and consists of an almond-shaped mass of gray matter in the anterior extremity of the temporal lobe.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000235,,,,,,,,The one of the four basal ganglia in each cerebral hemisphere that is part of the limbic system and consists of an almond-shaped mass of gray matter in the anterior extremity of the temporal lobe.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001042,,,,,,,BrendaTissueOBO,amygdaloid nuclear complex|nucleus amygdalae|corpus amygdaloideum|amygdaloid body|amygdaloid complex|amygdaloid nucleus|archistriatum|amygdaloid nuclear group,BTO:0001042,,,,,,,,,,,,,,,,,,,amygdala,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300442,"[""B (Shab) subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300442,,,,,,,,,,,,,,,,,,,,,,,,,,,,B (Shab) subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100303,"[""Olfactory receptor 10G6""]",,"An olfactory receptor 10G6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH81] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10G6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH81] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100303,,,,https://pharos.nih.gov/idg/targets/Q8NH81,,,,,,,,,,,,,OR10G6,OR10G6P,,Q8NH81,,,,,,,,Olfactory receptor 10G6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002058,"[""non-small cell lung cancer cell""]",,"A general term comprising all lung carcinomas except small cell carcinoma, and including adenocarcinoma of the lung, large cell carcinoma, and squamous cell carcinoma.",false,,,http://purl.obolibrary.org/obo/BTO_0002061|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A general term comprising all lung carcinomas except small cell carcinoma, and including adenocarcinoma of the lung, large cell carcinoma, and squamous cell carcinoma.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002058,,,,,,,BrendaTissueOBO,NSCLC cell|non-small cell carcinoma cell|non-small cell lung carcinoma cell,BTO:0002058,,,,,,,,,,,,,,,,,,,non-small cell lung cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1909,"[""melanoma""]",,"A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye.",false,,,http://purl.obolibrary.org/obo/DOID_0050687,,,,,,,,"A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1909,,,,MESH:D008545|UMLS_CUI:C0025202|SNOMEDCT_US_2016_03_01:269503007|EFO:0000756|SNOMEDCT_US_2016_03_01:2092003|KEGG:05218|NCI:C3224|SNOMEDCT_US_2016_03_01:154501005|SNOMEDCT_US_2016_03_01:372244006|SNOMEDCT_US_2016_03_01:189749008|SNOMEDCT_US_2016_03_01:269577007|OMIM:155600,malignant melanoma|Naevocarcinoma,,disease_ontology,,DOID:1909,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,melanoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003250,"[""colonic epithelium cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003250,,,,,,,BrendaTissueOBO,colon epithelial cell line|colonic epithelial cell line,BTO:0003250,,,,,,,,,,,,,,,,,,,colonic epithelium cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000009,"[""ABL1(F317L) kinase domain""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000009,,,,,,,,,,,,,,,,,,,,,,,,,,,,ABL1(F317L) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100286,"[""Neurotensin receptor type 1""]",,"A neurotensin receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30989] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300072,,,,,,,,"A neurotensin receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30989] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100286,,,,https://pharos.nih.gov/idg/targets/P30989,,,,,,,,,,,,,NTSR1,NTRR,,P30989,,,,,,,,Neurotensin receptor type 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12510,"[""retinal ischemia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5679,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12510,,,,ICD9CM:362.84|UMLS_CUI:C0162291|SNOMEDCT_US_2016_03_01:193427006|SNOMEDCT_US_2016_03_01:26468004|ICD10CM:H35.82,,,disease_ontology,,DOID:12510,,,,,,,,,,,,,,,,,,,retinal ischemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100817,"[""Vasopressin V2 receptor""]",,"A vasopressin V2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30518] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A vasopressin V2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30518] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100817,,,,https://pharos.nih.gov/idg/targets/P30518,,,,,,,,,,,,,AVPR2,ADHR|DIR|DIR3|V2R,,P30518,,,,,,,,Vasopressin V2 receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5309,"[""epithelial-myoepithelial carcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_8850,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5309,,,,SNOMEDCT_US_2016_03_01:9618003|UMLS_CUI:C0334392|SNOMEDCT_US_2016_03_01:189722008|NCI:C4199,,,disease_ontology,,DOID:5309,,,,,,,,,,,,,,,,,,,epithelial-myoepithelial carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1727,"[""retinal vein occlusion""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1729,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1727,,,,SNOMEDCT_US_2016_03_01:46085004|UMLS_CUI:C0035328|MESH:D012170|NCI:C34981,"Occlusion, of retinal vein|Retinal vein occlusion",,disease_ontology,,DOID:1727,,,,,,,,,,,,,,,,,,,retinal vein occlusion,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100524,"[""Olfactory receptor 2G2""]",,"An olfactory receptor 2G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100524,,,,https://pharos.nih.gov/idg/targets/Q8NGZ5,,,,,,,,,,,,,OR2G2,,,Q8NGZ5,,,,,,,,Olfactory receptor 2G2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100194,"[""Prosaposin receptor gpr37""]",,"A G-protein coupled receptor 37 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O15354] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 37 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O15354] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100194,,,,https://pharos.nih.gov/idg/targets/O15354,,,,,,,,,,,,,GPR37,,,O15354,,,,,,,,Prosaposin receptor gpr37,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100115,"[""Galanin receptor type 1""]",,"A galanin receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47211] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300046,,,,,,,,"A galanin receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47211] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100115,,,,https://pharos.nih.gov/idg/targets/P47211,,,,,,,,,,,,,GALR1,GALNR|GALNR1,,P47211,,,,,,,,Galanin receptor type 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200620,"[""OR5D14 gene""]",,"An olfactory receptor 5D14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5D14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200620,,,,,,,,,,,,,,,,219436,OR5D14,,,,,,,,,,,OR5D14 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5363,"[""myxoid liposarcoma""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_3382,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5363,,,,OMIM:613488|SNOMEDCT_US_2016_03_01:27849002|UMLS_CUI:C0206634|SNOMEDCT_US_2016_03_01:404069006|MESH:D018208,Myxoid liposarcoma (disorder)|Myxoid liposarcoma (morphologic abnormality)|Myxoid Liposarcoma,,disease_ontology,,DOID:5363,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,myxoid liposarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100291,"[""Sodium channel protein type 2 subunit alpha""]",,"A sodium channel protein type 2 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99250] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300465,,,,,,,,"A sodium channel protein type 2 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99250] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100291,,,,https://pharos.nih.gov/idg/targets/Q99250,,,,,,,,,,,,,SCN2A,NAC2|SCN2A1|SCN2A2,,Q99250,,,,,,,,Sodium channel protein type 2 subunit alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005194,"[""fine root""]",,"Primary roots usually <2 mm diameter that have the function of water and nutrient uptake. They are often heavily branched and support mycorrhizas. These roots may be short lived, but are replaced by the plant in an ongoing process of root 'turnover'.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001182,,,,,,,,"Primary roots usually <2 mm diameter that have the function of water and nutrient uptake. They are often heavily branched and support mycorrhizas. These roots may be short lived, but are replaced by the plant in an ongoing process of root 'turnover'.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005194,XPMUser,2011-09-01T08:33:48Z,,,,,BrendaTissueOBO,,BTO:0005194,,,,,,,,,,,,,,,,,,,fine root,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400374,"[""5-hydroxytryptamine receptor subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400328,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400374,,,,,,,,,,,,,,,,,,,,,,,,,,,,5-hydroxytryptamine receptor subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1575,"[""rheumatic disease""]",,"A hypersensitivity reaction type II disease that involves inflammation or pain in the muscles, joints, or fibrous tissue.",false,,,http://purl.obolibrary.org/obo/DOID_0060032|http://purl.obolibrary.org/obo/DOID_65,,,,,,,,"A hypersensitivity reaction type II disease that involves inflammation or pain in the muscles, joints, or fibrous tissue.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1575,,,,,,,disease_ontology,,DOID:1575,,,,,,,,,,,,,,,,,,,rheumatic disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004694,"[""rectal sac""]",,"The enlarged anterior part of the rectum, sometimes produced into a large rectal caecum.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The enlarged anterior part of the rectum, sometimes produced into a large rectal caecum.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004694,mgr,2010-05-14T11:49:59Z,,,,,BrendaTissueOBO,,BTO:0004694,,,,,,,,,,,,,,,,,,,rectal sac,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002246,"[""globus pallidus""]",,"The smaller and more medial part of the lentiform nucleus of the brain, separated from the putamen by the lateral medullary lamina. In official anatomic nomenclature, it is divided by the medial medullary lamina into two parts, lateral and medial, both of which have extensive connections with the corpus striatum, thalamus, and mesencephalon. The paleostriatum is the phylogenetically older part of the corpus striatum represented by the globus pallidus.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The smaller and more medial part of the lentiform nucleus of the brain, separated from the putamen by the lateral medullary lamina. In official anatomic nomenclature, it is divided by the medial medullary lamina into two parts, lateral and medial, both of which have extensive connections with the corpus striatum, thalamus, and mesencephalon. The paleostriatum is the phylogenetically older part of the corpus striatum represented by the globus pallidus.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002246,,,,,,,BrendaTissueOBO,pallidum|pale body|paleostriatum,BTO:0002246,,,,,,,,,,,,,,,,,,,globus pallidus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000316,"[""THR267 in ACVR2A""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000316,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR267 in ACVR2A,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100144,"[""Probable g-protein coupled receptor 135""]",,"A G-protein coupled receptor 135 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8IZ08] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300037,,,,,,,,"A G-protein coupled receptor 135 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8IZ08] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100144,,,,https://pharos.nih.gov/idg/targets/Q8IZ08,,,,,,,,,,,,,GPR135,,,Q8IZ08,,,,,,,,Probable g-protein coupled receptor 135,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_496,"[""spindle cell hemangioma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_255,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:496,,,,UMLS_CUI:C1304508|SNOMEDCT_US_2016_03_01:134304005|SNOMEDCT_US_2016_03_01:403967000|SNOMEDCT_US_2016_03_01:128769003|NCI:C4754,spindle cell angioendothelioma|spindle cell hemangioma (disorder)|spindle cell hemangioendothelioma [dup] (morphologic abnormality)|SCH,,disease_ontology,,DOID:496,,,,,,,,,,,,,,,,,,,spindle cell hemangioma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300451,"[""V subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300451,,,,,,,,,,,,,,,,,,,,,,,,,,,,V subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1781,"[""thyroid cancer""]",,An endocrine gland cancer located_in the thryoid gland located in the neck below the thyroid cartilage.,false,,,http://purl.obolibrary.org/obo/DOID_170|http://purl.obolibrary.org/obo/DOID_50,,,,,,,,An endocrine gland cancer located_in the thryoid gland located in the neck below the thyroid cartilage.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1781,,,DOID:10008,ICD10CM:C73|SNOMEDCT_US_2016_03_01:154554008|SNOMEDCT_US_2016_03_01:363478007|NCI:C3414|SNOMEDCT_US_2016_03_01:127018007|UMLS_CUI:C0040136|ICD9CM:193|NCI:C7510|UMLS_CUI:C0007115|SNOMEDCT_US_2016_03_01:94098005|MESH:D013964|KEGG:05216,Thyroid gland neoplasm|thyroid neoplasm|malignant tumour of thyroid gland|neoplasm of thyroid gland|malignant neoplasm of thyroid gland,,disease_ontology,,DOID:1781,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,thyroid cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000419,"[""respiratory epithelium""]",,Epithelium of the respiratory portion of the bronchial tree.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000416,,,,,,,,Epithelium of the respiratory portion of the bronchial tree.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000419,,,,,,,BrendaTissueOBO,airway epithelium,BTO:0000419,,,,,,,,,,,,,,,,,,,respiratory epithelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004007,"[""porcine aortic endothelial cell""]",,Porcine aortic endothelial cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003246,,,,,,,,Porcine aortic endothelial cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004007,,,,,,,BrendaTissueOBO,PAEC cell,BTO:0004007,,,,,,,,,,,,,,,,,,,porcine aortic endothelial cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004766,"[""SET-2 cell""]",,Acute myeloid leukemia cell line. Human essential thrombocythemia cell line; established from the peripheral blood of a 71-year-old woman with essential thrombocythemia at megakaryoblastic leukemic transformation.,false,,,http://purl.obolibrary.org/obo/BTO_0001883|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Acute myeloid leukemia cell line. Human essential thrombocythemia cell line; established from the peripheral blood of a 71-year-old woman with essential thrombocythemia at megakaryoblastic leukemic transformation.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004766,mgr,2010-10-02T10:24:42Z,,,,,BrendaTissueOBO,,BTO:0004766,,,,,,,,,,,,,,,,,,,SET-2 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000819,"[""pharyngeal cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000819,,,,,,,BrendaTissueOBO,pharynx cell line,BTO:0000819,,,,,,,,,,,,,,,,,,,pharyngeal cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200211,"[""GPR83 gene""]",,"A G-protein coupled receptor 83 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NYM4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 83 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NYM4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200211,,,,,,,,,,,,,,,,10888,GPR83,GPR72|KIAA1540,,,,,,,,,,GPR83 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2870,"[""endometrial adenocarcinoma""]",,An endometrial carcinoma that derives_from epithelial cells of glandular origin.,false,,,http://purl.obolibrary.org/obo/DOID_299|http://purl.obolibrary.org/obo/DOID_2871,,,,,,,,An endometrial carcinoma that derives_from epithelial cells of glandular origin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2870,,,DOID:6650|DOID:5827,SNOMEDCT_US_2016_03_01:309245001|NCI:C6290|NCI:C6287|SNOMEDCT_US_2016_03_01:189649001|UMLS_CUI:C0279763|NCI:C7359|SNOMEDCT_US_2016_03_01:189652009|UMLS_CUI:C1336905|SNOMEDCT_US_2016_03_01:123845008|UMLS_CUI:C1153706,endometrioid adenomas and carcinomas (morphologic abnormality)|adenocarcinoma of endometrium (disorder)|endometrioid adenoma or carcinoma NOS (morphologic abnormality)|adenocarcinoma of uterus (disorder)|endometrioid carcinoma of Endometrium|endometrial endometrioid adenocarcinoma|endometrial adenoacanthoma|adenocarcinoma of the Endometrium|endometrial endometrioid adenocarcinoma with squamous differentiation,,disease_ontology,,DOID:2870,,,,,,,,,,,,,,,,,,,endometrial adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_850,"[""lung disease""]",,"A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide.",false,,,http://purl.obolibrary.org/obo/DOID_0050161,,,,,,,,"A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:850,,,DOID:11895|DOID:11894|DOID:766|DOID:29,SNOMEDCT_US_2016_03_01:196164004|ICD10CM:J98.4|MESH:D008171|UMLS_CUI:C0024115|SNOMEDCT_US_2016_03_01:266374002|NCI:C3198|SNOMEDCT_US_2016_03_01:19829001,,,disease_ontology,,DOID:850,,,,,,,,,,,,,,,,,Updating out dated CUI and removing lung abscess as a synonym.,,lung disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_854,"[""collagen disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_65,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:854,,,,SNOMEDCT_US_2016_03_01:201454004|SNOMEDCT_US_2016_03_01:268048008|UMLS_CUI:C0009326|NCI:C27204|SNOMEDCT_US_2016_03_01:81573002|SNOMEDCT_US_2016_03_01:201434000|SNOMEDCT_US_2016_03_01:156458006|MESH:D003095,collagen disorder,,disease_ontology,,DOID:854,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,collagen disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9521,"[""Laron syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050737,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9521,,,,ICD10CM:E34.3|SNOMEDCT_US_2016_03_01:38196001|UMLS_CUI:C0271568|MESH:D046150|OMIM:262500,Laron-type isolated somatotropin defect (disorder),,disease_ontology,,DOID:9521,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Laron syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000807,"[""chorionic cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000807,,,,,,,BrendaTissueOBO,,BTO:0000807,,,,,,,,,,,,,,,,,,,chorionic cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003423,"[""lacrimal gland acinar cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003423,,,,,,,BrendaTissueOBO,,BTO:0003423,,,,,,,,,,,,,,,,,,,lacrimal gland acinar cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003361,"[""anterior visceral endoderm""]",,The anterior visceral endoderm (AVE) is an extra-embryonic tissue required for specifying anterior pattern in the mouse embryo.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000315,,,,,,,,The anterior visceral endoderm (AVE) is an extra-embryonic tissue required for specifying anterior pattern in the mouse embryo.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003361,,,,,,,BrendaTissueOBO,AVE,BTO:0003361,,,,,,,,,,,,,,,,,,,anterior visceral endoderm,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004499,"[""prostate gland intraepithelial neoplasia cell line""]",,Prostatic intraepithelial neoplasia (PIN) is a microscopic lesion in the prostate which is thought to be a precursor to prostate cancer.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002398,,,,,,,,Prostatic intraepithelial neoplasia (PIN) is a microscopic lesion in the prostate which is thought to be a precursor to prostate cancer.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004499,Marion,2010-02-08T12:08:40Z,,,,,BrendaTissueOBO,prostate intraepithelial neoplasia cell line|PIN cell|PIN cell line|prostatic intraepithelial neoplasia cell line,BTO:0004499,,,,,,,,,,,,,,,,,,,prostate gland intraepithelial neoplasia cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200479,"[""SMG1 gene""]",,"This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined. [provided by RefSeq, Mar 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400129,,,,,,,,"This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined. [provided by RefSeq, Mar 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200479,,,,,,,,,,,,,,,,23049,SMG1,ATX|KIAA0421|LIP,,,,,,,,,,SMG1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200303,"[""OR10G6 gene""]",,"An olfactory receptor 10G6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH81] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10G6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH81] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200303,,,,,,,,,,,,,,,,79490,OR10G6,OR10G6P,,,,,,,,,,OR10G6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_29105,"[""zinc(2+)""]","ZINC ION|zinc cation|63.929|[Zn++]|Zn|InChI=1S/Zn/q+2|PTFCDOFLOPIGGS-UHFFFAOYSA-N|zinc, ion (Zn2+)|Zn(II)|Zn2+|Zn(2+)|65.39000|+2|dietary zinc",,false,,,http://purl.obolibrary.org/obo/CHEBI_36916,,,,,,,PDBeChem:ZN|Gmelin:6869|CAS:23713-49-7|KEGG:C00038,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:27368|CHEBI:10113|CHEBI:49972|CHEBI:49982,,zinc(II) cation|zinc(2+)|zinc(2+) ion,,chebi_ontology,"ZINC ION|zinc cation|63.929|[Zn++]|Zn|InChI=1S/Zn/q+2|PTFCDOFLOPIGGS-UHFFFAOYSA-N|zinc, ion (Zn2+)|Zn(II)|Zn2+|Zn(2+)|65.39000|+2|dietary zinc",,,CHEBI:29105,,,,,,,,,,,,,,,,,,,,,,,CHEBI:29105,,,,,zinc(2+),,CHEBI:29105,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200203,"[""KALRN gene""]",,"Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400168,,,,,,,,"Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200203,,,,,,,,,,,,,,,,8997,KALRN,DUET|DUO|HAPIP,,,,,,,,,,KALRN gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300392,"[""CFTR transporter subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300338,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300392,,,,,,,,,,,,,,,,,,,,,,,,,,,,CFTR transporter subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100256,"[""Glutamate receptor ionotropic, NMDA 3B""]",,"A glutamate receptor ionotropic, NMDA 3B that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60391] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300454,,,,,,,,"A glutamate receptor ionotropic, NMDA 3B that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60391] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100256,,,,https://pharos.nih.gov/idg/targets/O60391,,,,,,,,,,,,,GRIN3B,,,O60391,,,,,,,,"Glutamate receptor ionotropic, NMDA 3B",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3117,"[""hepatobiliary benign neoplasm""]",,A gastrointestinal system benign neoplasm located_in the hepatobiliary system.,false,,,http://purl.obolibrary.org/obo/DOID_0050624,,,,,,,,A gastrointestinal system benign neoplasm located_in the hepatobiliary system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3117,,,,NCI:C8614|UMLS_CUI:C0854196,hepatobiliary tumors,,disease_ontology,,DOID:3117,,,,,,,,,,,,,,,,,,,hepatobiliary benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400462,"[""RYR3 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400354,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400462,,,,,,,,,,,,,,,,,,,,,,,,,,,,RYR3 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200464,"[""GPR68 gene""]",,"A sphingosylphosphorylcholine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15743] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A sphingosylphosphorylcholine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15743] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200464,,,,,,,,,,,,,,,,8111,GPR68,OGR1,,,,,,,,,,GPR68 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100239,"[""Potassium voltage-gated channel subfamily s member 3""]",,"A voltage-gated potassium channel KCNS3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9BQ31] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300568,,,,,,,,"A voltage-gated potassium channel KCNS3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9BQ31] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100239,,,,https://pharos.nih.gov/idg/targets/Q9BQ31,,,,,,,,,,,,,KCNS3,,,Q9BQ31,,,,,,,,Potassium voltage-gated channel subfamily s member 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217551,"[""RXRA gene""]",,"Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_00217468,,,,,,,,"Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217551,,,,,,,,,,,,,,,,6256,RXRA,NR2B1,,,,,,,,,,RXRA gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100793,"[""Taste receptor type 2 member 1""]",,"A taste receptor type 2 member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300014,,,,,,,,"A taste receptor type 2 member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100793,,,,https://pharos.nih.gov/idg/targets/Q9NYW7,,,,,,,,,,,,,TAS2R1,,,Q9NYW7,,,,,,,,Taste receptor type 2 member 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000115,"[""DRAK1 kinase domain""]",,Serine/threonine kinase 17a; DRAK1; STK17A,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine kinase 17a; DRAK1; STK17A,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000115,,,,,,,,,,,,,,,,,,,200117,,,,,,,,,DRAK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200534,"[""TPK1 gene""]",,"This gene encodes a protein, that exists as a homodimer, which catalyzes the conversion of thiamine to thiamine pyrophosphate. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03491023,,,,,,,,"This gene encodes a protein, that exists as a homodimer, which catalyzes the conversion of thiamine to thiamine pyrophosphate. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200534,,,,,,,,,,,,,,,,27010,TPK1,,,,,,,,,,,TPK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3069,"[""astrocytoma""]",,"A malignant glioma that is has_material_basis_in astocyte cells, a type of star-shaped glial cell, located_in the cerebrum.",false,,,http://purl.obolibrary.org/obo/DOID_3070,,,,,,,,"A malignant glioma that is has_material_basis_in astocyte cells, a type of star-shaped glial cell, located_in the cerebrum.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3069,,,DOID:4861,SNOMEDCT_US_2016_03_01:99131000119108|SNOMEDCT_US_2016_03_01:38713004|NCI:C6958|UMLS_CUI:C0004114|SNOMEDCT_US_2016_03_01:189914005|NCI:C60781|UMLS_CUI:C0750935|NCI:C4951|MESH:D001254,"astrocytoma of Cerebrum|astrocytoma, no ICD-O subtype (morphologic abnormality)|astrocytoma of brain (disorder)|cerebral astrocytoma|astroglioma|Astrocytic tumor",,disease_ontology,,DOID:3069,,,,,,,,,,,,,,,,,,,astrocytoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000104,"[""CTK kinase domain""]",,Megakaryocyte-associated tyrosine kinase; CHK; CTK; DKFZp434N1212; HHYLTK; HYL; HYLTK; Lsk; MATK; MGC1708; MGC2101,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Megakaryocyte-associated tyrosine kinase; CHK; CTK; DKFZp434N1212; HHYLTK; HYL; HYLTK; Lsk; MATK; MGC1708; MGC2101,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000104,,,,,,,,,,,,,,,,,,,200105,,,,,,,,,CTK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100616,"[""Olfactory receptor 5B17""]",,"An olfactory receptor 5B17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5B17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100616,,,,https://pharos.nih.gov/idg/targets/Q8NGF7,,,,,,,,,,,,,OR5B17,OR5B20P,,Q8NGF7,,,,,,,,Olfactory receptor 5B17,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400137,"[""CDC7 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400137,,,,,,,,,,,,,,,,,,,,,,,,,,,,CDC7 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005810,"[""immune system""]",,"The bodily system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymph nodes, special deposits of lymphoid tissue (as in the gastrointestinal tract and bone marrow), macrophages, lymphocytes including the B cells and T cells, and antibodies.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The bodily system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymph nodes, special deposits of lymphoid tissue (as in the gastrointestinal tract and bone marrow), macrophages, lymphocytes including the B cells and T cells, and antibodies.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005810,Marion,2015-10-20T16:30:07Z,,,,,BrendaTissueOBO,,BTO:0005810,,,,,,,,,,,,,,,,,,,immune system,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200288,"[""MAP3K6 gene""]",,"This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400186,,,,,,,,"This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200288,,,,,,,,,,,,,,,,9064,MAP3K6,ASK2|MAPKKK6|MEKK6,,,,,,,,,,MAP3K6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001281,"[""spleen""]",,"A highly vascular ductless organ that is located in the left abdominal region near the stomach or intestine of most vertebrates and is concerned with final destruction of red blood cells, filtration and storage of blood, and production of lymphocytes.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001491|http://purl.obolibrary.org/obo/BTO_0000753,,,,,,,,"A highly vascular ductless organ that is located in the left abdominal region near the stomach or intestine of most vertebrates and is concerned with final destruction of red blood cells, filtration and storage of blood, and production of lymphocytes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001281,,,,,,,BrendaTissueOBO,,BTO:0001281,,,,,,,,,,,,,,,,,,,spleen,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200673,"[""OR6Y1 gene""]",,"An olfactory receptor 6Y1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6Y1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200673,,,,,,,,,,,,,,,,391112,OR6Y1,OR6Y2,,,,,,,,,,OR6Y1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200094,"[""FFAR1 gene""]",,"A free fatty acid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14842] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400040,,,,,,,,"A free fatty acid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14842] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200094,,,,,,,,,,,,,,,,2864,FFAR1,GPR40,,,,,,,,,,FFAR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2326,"[""gastroenteritis""]",,"A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. Chemicals and drugs also cause gastroenteritis. The symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen.",false,,,http://purl.obolibrary.org/obo/DOID_77,,,,,,,,"A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. Chemicals and drugs also cause gastroenteritis. The symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2326,,,DOID:5269|DOID:4094,ICD10CM:K52.9|SNOMEDCT_US_2016_03_01:197010007|UMLS_CUI:C0017160|SNOMEDCT_US_2016_03_01:154278002|MESH:D005759|SNOMEDCT_US_2016_03_01:25374005|SNOMEDCT_US_2016_03_01:266179001|NCI:C34632,"cholera morbus|infectious colitis, enteritis and gastroenteritis",,disease_ontology,,DOID:2326,,,,,,,,,,,,,,,,,,,gastroenteritis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9743,"[""diabetic neuropathy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_870,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9743,,,,SNOMEDCT_US_2016_03_01:267472008|MESH:D003929|NCI:C26748|SNOMEDCT_US_2016_03_01:230572002|SNOMEDCT_US_2016_03_01:866003|ICD9CM:250.6|SNOMEDCT_US_2016_03_01:193182005|SNOMEDCT_US_2016_03_01:190353001|SNOMEDCT_US_2016_03_01:190349003|SNOMEDCT_US_2016_03_01:154683002|UMLS_CUI:C0011882,,,disease_ontology,,DOID:9743,,,,,,,,,,,,,,,,,,,diabetic neuropathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400152,"[""EGFR family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400152,,,,,,,,,,,,,,,,,,,,,,,,,,,,EGFR family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100480,"[""Olfactory receptor 1C1""]",,"An olfactory receptor 1C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15619] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15619] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100480,,,,https://pharos.nih.gov/idg/targets/Q15619,,,,,,,,,,,,,OR1C1,,,Q15619,,,,,,,,Olfactory receptor 1C1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400096,"[""C-X3-C chemokine receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400031,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400096,,,,,,,,,,,,,,,,,,,,,,,,,,,,C-X3-C chemokine receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02402009,"[""NPY6R gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400071,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02402009,,,,,,,,,,,,,,,,,NPY6R,,,,,,,,,,,NPY6R gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3401,"[""inappropriate ADH syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_53,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3401,,,,SNOMEDCT_US_2016_03_01:389983008|UMLS_CUI:C0021141|ICD10CM:E22.2|MESH:D007177|NCI:C3988|SNOMEDCT_US_2016_03_01:55004003,syndrome of inappropriate secretion of antidiuretic hormone|syndrome of Inappropriate Antidiuretic Hormone Secretion|syndrome of inappropriate vasopressin secretion (disorder)|syndrome of inappropriate secretion of ADH,,disease_ontology,,DOID:3401,,,,,,,,,,,,,,,,,,,inappropriate ADH syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400130,"[""AUR family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400130,,,,,,,,,,,,,,,,,,,,,,,,,,,,AUR family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400179,"[""RSKL family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400179,,,,,,,,,,,,,,,,,,,,,,,,,,,,RSKL family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000080,"[""male reproductive gland""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001488,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000080,,,,,,,BrendaTissueOBO,,BTO:0000080,,,,,,,,,,,,,,,,,,,male reproductive gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100252,"[""Melanocortin receptor 3""]",,"A melanocortin receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41968] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300021,,,,,,,,"A melanocortin receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41968] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100252,,,,https://pharos.nih.gov/idg/targets/P41968,,,,,,,,,,,,,MC3R,,,P41968,,,,,,,,Melanocortin receptor 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200527,"[""OR2H1 gene""]",,"An olfactory receptor 2H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZK4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZK4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200527,,,,,,,,,,,,,,,,26716,OR2H1,OR2H6|OR2H8,,,,,,,,,,OR2H1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004720,"[""mural cell""]",,A nonendothelial cell enclosed within the basement membrane of retinal capillaries.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A nonendothelial cell enclosed within the basement membrane of retinal capillaries.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004720,mgr,2010-07-22T10:21:53Z,,,,,BrendaTissueOBO,,BTO:0004720,,,,,,,,,,,,,,,,,,,mural cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01390001,"[""Anion-transporting ion channel""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01390001,,,,,,,,,,,,,,,,,,,,,,,,,,,,Anion-transporting ion channel,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001756,"[""meningioma cell""]",,"A cell of a slow-growing tumor of the meninges, occurring most often in adults.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001573,,,,,,,,"A cell of a slow-growing tumor of the meninges, occurring most often in adults.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001756,,,,,,,BrendaTissueOBO,,BTO:0001756,,,,,,,,,,,,,,,,,,,meningioma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100430,"[""Serine/threonine-protein kinase plk1""]",,"serine/threonine-protein kinase plk1 (PLK1)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase PLK1 that is encoded in the genome of human. [PMID:16129782, PMID:16580887, PMID:16760428, PMID:17376779, PMID:20624902, PMID:20823832, PRO:KER] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300211,,,,,,,,"serine/threonine-protein kinase plk1 (PLK1)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase PLK1 that is encoded in the genome of human. [PMID:16129782, PMID:16580887, PMID:16760428, PMID:17376779, PMID:20624902, PMID:20823832, PRO:KER] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100430,,,,https://pharos.nih.gov/idg/targets/P53350,,,,,,,,,,,,,PLK1,PLK,,P53350,,,,,,,,Serine/threonine-protein kinase plk1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000176,"[""MET465 in DCLK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000176,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET465 in DCLK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000554,"[""hair follicle""]",,The tubular epithelial sheath that surrounds the lower part of the hair shaft and encloses at the bottom a vascular papilla supplying the growing basal part of the hair with nourishment.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001470,,,,,,,,The tubular epithelial sheath that surrounds the lower part of the hair shaft and encloses at the bottom a vascular papilla supplying the growing basal part of the hair with nourishment.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000554,,,,,,,BrendaTissueOBO,,BTO:0000554,,,,,,,,,,,,,,,,,,,hair follicle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000191,"[""MET636 in FES""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000191,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET636 in FES,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8567,"[""Hodgkin's lymphoma""]",,A lymphoma that is marked by the presence of a type of cell called the Reed-Sternberg cell.,false,,,http://purl.obolibrary.org/obo/DOID_0060058,,,,,,,,A lymphoma that is marked by the presence of a type of cell called the Reed-Sternberg cell.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8567,,,DOID:9107|DOID:8685|DOID:8841|DOID:8652|DOID:8671|DOID:0060059|DOID:8715|DOID:9096|DOID:8953|DOID:8710,NCI:C26956|NCI:C9357|EFO:0000183|ORDO:98293|SNOMEDCT_US_2016_03_01:188605006|SNOMEDCT_US_2016_03_01:52337003|OMIM:400021|SNOMEDCT_US_2016_03_01:309831004|MESH:D006689|SNOMEDCT_US_2016_03_01:188522003|SNOMEDCT_US_2016_03_01:118599009|SNOMEDCT_US_2016_03_01:118602004|SNOMEDCT_US_2016_03_01:189987006|SNOMEDCT_US_2016_03_01:118606001|SNOMEDCT_US_2016_03_01:46923007|UMLS_CUI:C0019829|SNOMEDCT_US_2016_03_01:188521005|SNOMEDCT_US_2016_03_01:188596006|ICD9CM:201.0|SNOMEDCT_US_2016_03_01:188532005|ICD10CM:C81.9|ICD10CM:C81|SNOMEDCT_US_2016_03_01:189991001|ICD9CM:201.1|ICD9CM:201|SNOMEDCT_US_2016_03_01:188543002|SNOMEDCT_US_2016_03_01:154582001|OMIM:300221|SNOMEDCT_US_2016_03_01:269509006|SNOMEDCT_US_2016_03_01:188552006|ICD9CM:201.9|SNOMEDCT_US_2016_03_01:74189002|SNOMEDCT_US_2016_03_01:118605002|OMIM:236000|SNOMEDCT_US_2016_03_01:188595005|SNOMEDCT_US_2016_03_01:14537002|SNOMEDCT_US_2016_03_01:188533000|SNOMEDCT_US_2016_03_01:188542007|NCI:C6914|ICD9CM:201.2|SNOMEDCT_US_2016_03_01:189992008|SNOMEDCT_US_2016_03_01:70600005,HL|Hodgkin's sarcoma|stage I Subdiaphragmatic Hodgkin Lymphoma|Hodgkins lymphoma|Hodgkin disease|Hodgkin lymphoma|stage II Subdiaphragmatic Hodgkin Lymphoma,,disease_ontology,,DOID:8567,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,Hodgkin's lymphoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200822,"[""VN1R3 gene""]",,"A vomeronasal type-1 receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BXE9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400016,,,,,,,,"A vomeronasal type-1 receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BXE9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200822,,,,,,,,,,,,,,,,317702,VN1R3,V1RL3,,,,,,,,,,VN1R3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200445,"[""OR5AC1 gene""]",,"An olfactory receptor 5AC1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C628] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5AC1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C628] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200445,,,,,,,,,,,,,,,,81431,OR5AC1,OR5AC1P,,,,,,,,,,OR5AC1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9779,"[""bowel dysfunction""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5295,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9779,,,,UMLS_CUI:C0016807|ICD9CM:564.9|SNOMEDCT_US_2016_03_01:81120009|ICD10CM:K59.9,,,disease_ontology,,DOID:9779,,,,,,,,,,,,,,,,,,,bowel dysfunction,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100631,"[""Olfactory receptor 5k2""]",,"An olfactory receptor 5K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHB8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHB8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100631,,,,https://pharos.nih.gov/idg/targets/Q8NHB8,,,,,,,,,,,,,OR5K2,,,Q8NHB8,,,,,,,,Olfactory receptor 5k2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5731,"[""chronic salpingitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5733,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5731,,,,ICD10CM:N70.11|SNOMEDCT_US_2016_03_01:55551005|UMLS_CUI:C0269041|NCI:C40118,,,disease_ontology,,DOID:5731,,,,,,,,,,,,,,,,,,,chronic salpingitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000050,"[""zona fasciculata""]",,The middle of the three layers of the adrenal cortex that consists of radially arranged columnar epithelial cells.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The middle of the three layers of the adrenal cortex that consists of radially arranged columnar epithelial cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000050,,,,,,,BrendaTissueOBO,,BTO:0000050,,,,,,,,,,,,,,,,,,,zona fasciculata,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200288,"[""SLC26A6 gene""]",,"This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_01400368,,,,,,,,"This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200288,,,,,,,,,,,,,,,,65010,SLC26A6,,,,,,,,,,,SLC26A6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200249,"[""MCOLN1 gene""]",,"This gene encodes a memberof the transient receptor potential (TRP) cation channel gene family. The transmembrane protein localizes to intracellular vesicular membranes including lysosomes, and functions in the late endocytic pathway and in the regulation of lysosomal exocytosis. The channel is permeable to Ca(2+), Fe(2+), Na(+), K(+), and H(+), and is modulated by changes in Ca(2+) concentration. Mutations in this gene result in mucolipidosis type IV. [provided by RefSeq, Oct 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400574,,,,,,,,"This gene encodes a memberof the transient receptor potential (TRP) cation channel gene family. The transmembrane protein localizes to intracellular vesicular membranes including lysosomes, and functions in the late endocytic pathway and in the regulation of lysosomal exocytosis. The channel is permeable to Ca(2+), Fe(2+), Na(+), K(+), and H(+), and is modulated by changes in Ca(2+) concentration. Mutations in this gene result in mucolipidosis type IV. [provided by RefSeq, Oct 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200249,,,,,,,,,,,,,,,,57192,MCOLN1,ML4,,,,,,,,,,MCOLN1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005552,"[""vertebral endplate""]",,Vertebral end plates are the top and bottom portions of the vertebral bodies that interface with the vertebral discs. The vertebral end plate is composed of a layer of thickened cancellous bone.,false,,,http://purl.obolibrary.org/obo/UBERON_0001474|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000140,,,,,,,,Vertebral end plates are the top and bottom portions of the vertebral bodies that interface with the vertebral discs. The vertebral end plate is composed of a layer of thickened cancellous bone.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005552,Marion,2014-02-26T14:51:05Z,,,,,BrendaTissueOBO,,BTO:0005552,,,,,,,,,,,,,,,,,,,vertebral endplate,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10611,"[""protein-losing enteropathy""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_5295,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10611,,,,UMLS_CUI:C0033680|MESH:D011504|SNOMEDCT_US_2016_03_01:66972006|SNOMEDCT_US_2016_03_01:22542007|OMIM:226300,"Exudative enteropathy (disorder)|Protein-losing enteropathy (disorder)|Enteropathy, exudative",,disease_ontology,,DOID:10611,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,protein-losing enteropathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100116,"[""Gamma-aminobutyric acid receptor subunit delta""]",,"A gamma-aminobutyric acid receptor subunit delta that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14764] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300515,,,,,,,,"A gamma-aminobutyric acid receptor subunit delta that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14764] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100116,,,,https://pharos.nih.gov/idg/targets/O14764,,,,,,,,,,,,,GABRD,,,O14764,,,,,,,,Gamma-aminobutyric acid receptor subunit delta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003623,"[""uterine fluid""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003632,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003623,,,,,,,BrendaTissueOBO,,BTO:0003623,,,,,,,,,,,,,,,,,,,uterine fluid,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300356,"[""Voltage-gated potassium channel -subunit (kv) family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300356,,,,,,,,,,,,,,,,,,,,,,,,,,,,Voltage-gated potassium channel -subunit (kv) family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050789,"[""tarsal-carpal coalition syndrome""]",,"An autosomal dominant disease that is characterized by fusion of the carpals, tarsals, and phalanges, short first metacarpals causing brachydactyly; and humeroradial fusion.",false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,"An autosomal dominant disease that is characterized by fusion of the carpals, tarsals, and phalanges, short first metacarpals causing brachydactyly; and humeroradial fusion.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050789,lschriml,2013-11-12T11:50:00Z,,OMIM:186570,,,disease_ontology,,DOID:0050789,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,tarsal-carpal coalition syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050785,"[""progressive relapsing multiple sclerosis""]",,A multiple sclerosis that is characterized by steadily worsening symptoms and attacks during periods of remission with disease progression from the onset.,false,,,http://purl.obolibrary.org/obo/DOID_2377,,,,,,,,A multiple sclerosis that is characterized by steadily worsening symptoms and attacks during periods of remission with disease progression from the onset.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050785,lschriml,2013-11-07T11:32:37Z,,SNOMEDCT_US_2016_03_01:230374002|UMLS_CUI:C0393666|MESH:D020528,Progressive-relapsing MS|PRMS,,disease_ontology,,DOID:0050785,,,,,,,,,,,,,,,,,,,progressive relapsing multiple sclerosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050782,"[""Zollinger-Ellison syndrome""]",,"A syndrome that is haracterized by the development of a one or more tumors (gastrinoma) in the pancreas, duodenum, or both that secrete excessive levels of gastrin, a hormone that stimulates production of acid by the stomach.",false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,"A syndrome that is haracterized by the development of a one or more tumors (gastrinoma) in the pancreas, duodenum, or both that secrete excessive levels of gastrin, a hormone that stimulates production of acid by the stomach.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050782,lschriml,2013-10-23T12:51:49Z,,MESH:D015043|SNOMEDCT_US_2016_03_01:267477002|UMLS_CUI:C0043515|ICD10CM:E16.4|SNOMEDCT_US_2016_03_01:190443003|SNOMEDCT_US_2016_03_01:154694003|NCI:C3453|SNOMEDCT_US_2016_03_01:53132006,,,disease_ontology,,DOID:0050782,,,,,,,,,,,,,,,,,,,Zollinger-Ellison syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050783,"[""secondary progressive multiple sclerosis""]",,"A multiple sclerosis that is characterised by a worsening of disability, rather than by relapses followed by recovery, which progressively worsens until a steady progression of disability replaces the cycles of attacks.",false,,,http://purl.obolibrary.org/obo/DOID_2377,,,,,,,,"A multiple sclerosis that is characterised by a worsening of disability, rather than by relapses followed by recovery, which progressively worsens until a steady progression of disability replaces the cycles of attacks.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050783,lschriml,2013-11-07T11:22:49Z,,SNOMEDCT_US_2016_03_01:425500002|MESH:D020528|UMLS_CUI:C0751965,SPMS|Secondary-progressive MS ,,disease_ontology,,DOID:0050783,,,,,,,,,,,,,,,,,,,secondary progressive multiple sclerosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050787,"[""juvenile polyposis syndrome""]",,"An autosomal dominant disease that is characterized by predisposition to hamartomatous benign polyps in the gastrointestinal tract, specifically in the stomach, small intestine, colon, and rectum.",false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,"An autosomal dominant disease that is characterized by predisposition to hamartomatous benign polyps in the gastrointestinal tract, specifically in the stomach, small intestine, colon, and rectum.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050787,lschriml,2013-11-12T11:25:28Z,,OMIM:174900,,,disease_ontology,,DOID:0050787,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,juvenile polyposis syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050788,"[""proximal symphalangism""]",,"An autosomal dominant disease that is characterized by ankylosis of the proximal interphalangeal joints, carpal and tarsal bone fusion, and conductive deafness.",false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,"An autosomal dominant disease that is characterized by ankylosis of the proximal interphalangeal joints, carpal and tarsal bone fusion, and conductive deafness.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050788,lschriml,2013-11-12T11:43:22Z,,OMIM:185800|KEGG:H00484,Cushing's symphalangism,,disease_ontology,,DOID:0050788,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,proximal symphalangism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100609,"[""Olfactory receptor 4x1""]",,"An olfactory receptor 4X1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH49] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4X1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH49] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100609,,,,https://pharos.nih.gov/idg/targets/Q8NH49,,,,,,,,,,,,,OR4X1,,,Q8NH49,,,,,,,,Olfactory receptor 4x1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100330,"[""Transient receptor potential cation channel subfamily M member 5""]",,"A transient receptor potential cation channel subfamily M member 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZQ8] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300587,,,,,,,,"A transient receptor potential cation channel subfamily M member 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZQ8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100330,,,,https://pharos.nih.gov/idg/targets/Q9NZQ8,,,,,,,,,,,,,TRPM5,LTRPC5|MTR1,,Q9NZQ8,,,,,,,,Transient receptor potential cation channel subfamily M member 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1383,"[""sweat gland disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_37,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1383,,,,UMLS_CUI:C0038986|SNOMEDCT_US_2016_03_01:201209003|ICD9CM:705.9|ICD10CM:L74|SNOMEDCT_US_2016_03_01:156413000|SNOMEDCT_US_2016_03_01:88232005|MESH:D013543|ICD10CM:L74.9|ICD9CM:705,,,disease_ontology,,DOID:1383,,,,,,,,,,,,,,,,,,,sweat gland disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13832,"[""patent ductus arteriosus""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_1682,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13832,,,,ICD9CM:747.0|OMIM:607411|SNOMEDCT_US_2016_03_01:156928009|SNOMEDCT_US_2016_03_01:83330001|NCI:C84492|UMLS_CUI:C0013274|ICD10CM:Q25.0|MESH:D004374,Patent ductus Botalli,,disease_ontology,"ductus arteriosus, Patent",DOID:13832,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,patent ductus arteriosus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4251,"[""conjunctival disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5614,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4251,,,,SNOMEDCT_US_2016_03_01:193906005|ICD10CM:H11.9|ICD9CM:372.9|SNOMEDCT_US_2016_03_01:59698003|ICD10CM:H10-H11|SNOMEDCT_US_2016_03_01:267735001|NCI:C27605|ICD9CM:372|UMLS_CUI:C0009759|SNOMEDCT_US_2016_03_01:194583004|SNOMEDCT_US_2016_03_01:155161009|MESH:D003229|SNOMEDCT_US_2016_03_01:155169006,,,disease_ontology,,DOID:4251,,,,,,,,,,,,,,,,,,,conjunctival disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000167,"[""MET414 in ZAP70""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000167,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET414 in ZAP70,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200720,"[""OR9Q2 gene""]",,"An olfactory receptor 9Q2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 9Q2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200720,,,,,,,,,,,,,,,,219957,OR9Q2,OR9Q2P,,,,,,,,,,OR9Q2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_18295,"[""histamine""]","5-Imidazoleethylamine|2-(1H-imidazol-4-yl)ethan-1-amine|beta-Aminothethylglyoxaline|C5H9N3|HSM|4-(2-Aminoethyl)-1H-imidazole|NTYJJOPFIAHURM-UHFFFAOYSA-N|beta-Aminoethylimidazole|Theramine|L-Histamine|2-(1H-Imidazol-4-yl)ethanamine|2-Imidazol-4-ylethylamine|Free histamine|
InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
|4-Imidazoleethylamine|1H-Imidazole-4-ethanamine|2-(4-Imidazolyl)ethanamine|Ergamine|2-Imidazol-4-yl-Ethylamine|2-(1H-imidazol-5-yl)ethylamine|2-(1H-imidazol-5-yl)ethanamine|Ergotidine|beta-Aminoethylglyoxaline|beta-Imidazolyl-4-ethylamine|b-Imidazolyl-4-ethylamine|Eramin|NCCc1c[nH]cn1|2-(1H-Imidazol-4-yl)ethylamine|2-(4-Imidazolyl)ethylamine|L-Histamin base|4-(2-Aminoethyl)imidazole","
A 1H-imidazol-4-yl group substituted at position C-4 by a 2-aminoethyl group.
",false,,,http://purl.obolibrary.org/obo/CHEBI_32952,,,,,,,CiteXplore:16689187|CiteXplore:6839633|CiteXplore:15555433|CiteXplore:19212411|CiteXplore:15610369|NIST Chemistry WebBook:51-45-6|Reaxys:2012|CiteXplore:9303324|CiteXplore:15626750|CiteXplore:19547708|CiteXplore:15725248|CiteXplore:15649269|CiteXplore:16365391|KEGG COMPOUND:51-45-6|CiteXplore:11084298|ChemIDplus:51-45-6|CiteXplore:2013627|Beilstein:2012|CiteXplore:19843401|Gmelin:2968|CiteXplore:15869544|MetaCyc:HISTAMINE|CiteXplore:16354198|CiteXplore:16760908|CiteXplore:7164933|HMDB:HMDB00870|CiteXplore:11603849|CiteXplore:16433856|PDBeChem:HSM|CiteXplore:10511481|CiteXplore:22770225|CiteXplore:15334189|KEGG DRUG:D08040|KEGG COMPOUND:C00388|Wikipedia:Histamine|KNApSAcK:C00001414|CiteXplore:16399866|CiteXplore:11272150|CiteXplore:24101735|CiteXplore:19309105,"
A 1H-imidazol-4-yl group substituted at position C-4 by a 2-aminoethyl group.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:14401|CHEBI:24596|CHEBI:43187|CHEBI:817,,Histamine|HISTAMINE|2-(1H-imidazol-4-yl)ethanamine,,chebi_ontology,"5-Imidazoleethylamine|2-(1H-imidazol-4-yl)ethan-1-amine|beta-Aminothethylglyoxaline|C5H9N3|HSM|4-(2-Aminoethyl)-1H-imidazole|NTYJJOPFIAHURM-UHFFFAOYSA-N|beta-Aminoethylimidazole|Theramine|L-Histamine|2-(1H-Imidazol-4-yl)ethanamine|2-Imidazol-4-ylethylamine|Free histamine|
InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
|4-Imidazoleethylamine|1H-Imidazole-4-ethanamine|2-(4-Imidazolyl)ethanamine|Ergamine|2-Imidazol-4-yl-Ethylamine|2-(1H-imidazol-5-yl)ethylamine|2-(1H-imidazol-5-yl)ethanamine|Ergotidine|beta-Aminoethylglyoxaline|beta-Imidazolyl-4-ethylamine|b-Imidazolyl-4-ethylamine|Eramin|NCCc1c[nH]cn1|2-(1H-Imidazol-4-yl)ethylamine|2-(4-Imidazolyl)ethylamine|L-Histamin base|4-(2-Aminoethyl)imidazole",,,CHEBI:18295,,,,,,,,,,,,,,,,,,,,,,,CHEBI:18295,,,,,Histamine|histamine,,CHEBI:18295,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001438,"[""vena cava""]",,Any of the large veins by which in air-breathing vertebrates the blood is returned to the right atrium of the heart.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000234,,,,,,,,Any of the large veins by which in air-breathing vertebrates the blood is returned to the right atrium of the heart.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001438,,,,,,,BrendaTissueOBO,,BTO:0001438,,,,,,,,,,,,,,,,,,,vena cava,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100261,"[""Glutamate receptor ionotropic, nmda 1""]",,"A glutamate [NMDA] receptor subunit zeta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q05586] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300459,,,,,,,,"A glutamate [NMDA] receptor subunit zeta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q05586] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100261,,,,https://pharos.nih.gov/idg/targets/Q05586,,,,,,,,,,,,,GRIN1,NMDAR1,,Q05586,,,,,,,,"Glutamate receptor ionotropic, nmda 1",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004414,"[""KH2 cell""]",,Murine embryonic stem cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001581,,,,,,,,Murine embryonic stem cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004414,Marion,2010-02-01T11:56:40Z,,,,,BrendaTissueOBO,,BTO:0004414,,,,,,,,,,,,,,,,,,,KH2 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8456,"[""choline deficiency disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5113,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8456,,,,UMLS_CUI:C0008412|SNOMEDCT_US_2016_03_01:238113006|MESH:D002796,Choline deficiency (disorder)|choline deficiency,,disease_ontology,,DOID:8456,,,,,,,,,,,,,,,,,,,choline deficiency disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001809,"[""scalp""]",,The part of the integument of the human head usually covered with hair in both sexes or the part of an animal (as a wolf or fox) corresponding to the human scalp.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The part of the integument of the human head usually covered with hair in both sexes or the part of an animal (as a wolf or fox) corresponding to the human scalp.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001809,,,,,,,BrendaTissueOBO,,BTO:0001809,,,,,,,,,,,,,,,,,,,scalp,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001096,"[""lymphoid cell""]",,"Any of the cells responsible for the production of immunity mediated by cells or antibodies and including lymphocytes, lymphoblasts, and plasma cells. Cells derived from stem cells of the lymphoid lineage: large and small lymphocytes, plasma cells.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Any of the cells responsible for the production of immunity mediated by cells or antibodies and including lymphocytes, lymphoblasts, and plasma cells. Cells derived from stem cells of the lymphoid lineage: large and small lymphocytes, plasma cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001096,,,,,,,BrendaTissueOBO,,BTO:0001096,,,,,,,,,,,,,,,,,,,lymphoid cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100192,"[""Interleukin-1 receptor-associated kinase 3""]",,"interleukin-1 receptor-associated kinase 3 (IRAK3)  with  no mutation  in a nonphosphorylated state|An interleukin-1 receptor-associated kinase 3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9Y616] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300166,,,,,,,,"interleukin-1 receptor-associated kinase 3 (IRAK3)  with  no mutation  in a nonphosphorylated state|An interleukin-1 receptor-associated kinase 3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9Y616] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100192,,,,https://pharos.nih.gov/idg/targets/Q9Y616,,,,,,,,,,,,,IRAK3,,,Q9Y616,,,,,,,,Interleukin-1 receptor-associated kinase 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200194,"[""KCND2 gene""]",,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400546,,,,,,,,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200194,,,,,,,,,,,,,,,,3751,KCND2,KIAA1044,,,,,,,,,,KCND2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001072,"[""trigeminal nerve""]",,"Either of the fifth pair of cranial nerves, having sensory and motor functions in the face, teeth, mouth, and nasal cavity.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001104,,,,,,,,"Either of the fifth pair of cranial nerves, having sensory and motor functions in the face, teeth, mouth, and nasal cavity.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001072,,,,,,,BrendaTissueOBO,cranial nerve V|trigeminus|fifth cranial nerve|nervus trigeminus,BTO:0001072,,,,,,,,,,,,,,,,,,,trigeminal nerve,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100328,"[""Map kinase-interacting serine/threonine-protein kinase 1""]",,"MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)  with  no mutation  in a nonphosphorylated state|A MAP kinase-interacting serine/threonine-protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BUB5] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300296,,,,,,,,"MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)  with  no mutation  in a nonphosphorylated state|A MAP kinase-interacting serine/threonine-protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BUB5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100328,,,,https://pharos.nih.gov/idg/targets/Q9BUB5,,,,,,,,,,,,,MKNK1,MNK1,,Q9BUB5,,,,,,,,Map kinase-interacting serine/threonine-protein kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004858,"[""ACT-1 cell""]",,Human anaplastic thyroid carcinoma cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0003209|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human anaplastic thyroid carcinoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004858,mgr,2010-10-11T02:12:47Z,,,,,BrendaTissueOBO,,BTO:0004858,,,,,,,,,,,,,,,,,,,ACT-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000207,"[""JNK3 kinase domain""]",,Mitogen-activated protein kinase 10; FLJ12099; FLJ33785; JNK3; JNK3A; MAPK10; MGC50974; p493F12; p54bSAPK; PRKM10,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase 10; FLJ12099; FLJ33785; JNK3; JNK3A; MAPK10; MGC50974; p493F12; p54bSAPK; PRKM10,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000207,,,,,,,,,,,,,,,,,,,200213,,,,,,,,,JNK3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100220,"[""Calcium/calmodulin-dependent protein kinase type ii subunit delta""]",,"A calcium/calmodulin-dependent protein kinase type II subunit delta that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13557] |calcium/calmodulin-dependent protein kinase type ii subunit delta (KCC2D)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300172,,,,,,,,"A calcium/calmodulin-dependent protein kinase type II subunit delta that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13557] |calcium/calmodulin-dependent protein kinase type ii subunit delta (KCC2D)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100220,,,,https://pharos.nih.gov/idg/targets/Q13557,,,,,,,,,,,,,CAMK2D,CAMKD,,Q13557,,,,,,,,Calcium/calmodulin-dependent protein kinase type ii subunit delta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001541,"[""pronephros""]",,"1. The primordial kidney; a vestigial excretory structure or its rudiments developing in the embryo at four weeks, before the mesonephros. Although nonfunctional, its duct is later used by the mesonephros, which arises caudal to it. 2. The definitive excretory organ of primitive fishes.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"1. The primordial kidney; a vestigial excretory structure or its rudiments developing in the embryo at four weeks, before the mesonephros. Although nonfunctional, its duct is later used by the mesonephros, which arises caudal to it. 2. The definitive excretory organ of primitive fishes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001541,,,,,,,BrendaTissueOBO,head kidney|pronephron|anterior kidney|archinephron|embryonic kidney,BTO:0001541,,,,,,,,,,,,,,,,,,,pronephros,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000194,"[""MET659 in KPCD1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000194,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET659 in KPCD1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001579,"[""extraocular muscle""]",,Any of six small voluntary muscles that pass between the eyeball and the orbit and control the movement of the eyeball in relation to the orbit.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000021,,,,,,,,Any of six small voluntary muscles that pass between the eyeball and the orbit and control the movement of the eyeball in relation to the orbit.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001579,,,,,,,BrendaTissueOBO,extra-ocular muscle|extrinsic muscle of eyeball,BTO:0001579,,,,,,,,,,,,,,,,,,,extraocular muscle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000192,"[""Kisspeptin-54""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000192,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kisspeptin-54,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200766,"[""S1PR4 gene""]",,"A sphingosine 1-phosphate receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95977] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A sphingosine 1-phosphate receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95977] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200766,,,,,,,,,,,,,,,,8698,S1PR4,EDG6,,,,,,,,,,S1PR4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100615,"[""Nicotinamide riboside kinase 2""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100615,,,,,,,,,,,,,,,,,NMRK2,,,Q9NPI5,,,,,,,,Nicotinamide riboside kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8534,"[""gastroesophageal reflux disease""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_77,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8534,,,,ICD10CM:K21|SNOMEDCT_US_2016_03_01:235595009|ICD9CM:530.81|SNOMEDCT_US_2016_03_01:698065002|SNOMEDCT_US_2016_03_01:155673008|NCI:C92560|OMIM:109350|SNOMEDCT_US_2016_03_01:266498005|SNOMEDCT_US_2016_03_01:196600005|ICD10CM:K21.9|NCI:C26781|UMLS_CUI:C0017168|SNOMEDCT_US_2016_03_01:196624002|MESH:D005764|SNOMEDCT_US_2016_03_01:102620007|SNOMEDCT_US_2016_03_01:54856001,Acid reflux|Gastro-esophageal reflux|Gastresophageal reflux|GERD|GERD - Gastro-esophageal reflux disease|Gastroesophageal reflux|Gastroesophageal reflux disease,,disease_ontology,,DOID:8534,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,gastroesophageal reflux disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001842,"[""pleural ganglion""]",,The pallial cavity's nerve knots are called pleural ganglia. They innerve primarily the mantle or a snail.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000497,,,,,,,,The pallial cavity's nerve knots are called pleural ganglia. They innerve primarily the mantle or a snail.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001842,,,,,,,BrendaTissueOBO,,BTO:0001842,,,,,,,,,,,,,,,,,,,pleural ganglion,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391018,"[""Thymidylate kinase family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300326,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391018,,,,,,,,,,,,,,,,,,,,,,,,,,,,Thymidylate kinase family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001911,"[""lung adenocarcinoma cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0000167|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000762,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001911,,,,,,,BrendaTissueOBO,,BTO:0001911,,,,,,,,,,,,,,,,,,,lung adenocarcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004513,"[""Sertoli cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0004229,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004513,mgr,2010-02-11T09:38:15Z,,,,,BrendaTissueOBO,,BTO:0004513,,,,,,,,,,,,,,,,,,,Sertoli cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200482,"[""SPHK1 gene""]",,"The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400323,,,,,,,,"The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200482,,,,,,,,,,,,,,,,8877,SPHK1,SPHK|SPK,,,,,,,,,,SPHK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300267,"[""Dyrk2 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300150,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300267,,,,,,,,,,,,,,,,,,,,,,,,,,,,Dyrk2 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3371,"[""chondrosarcoma""]",,A connective tissue cancer that has_material_basis_in cells derived from transformed cells that produce cartilage.,false,,,http://purl.obolibrary.org/obo/DOID_201,,,,,,,,A connective tissue cancer that has_material_basis_in cells derived from transformed cells that produce cartilage.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3371,,,DOID:3370,UMLS_CUI:C1335473|OMIM:215300|SNOMEDCT_US_2016_03_01:14990007|NCI:C2946|NCI:C7155|MESH:D002813|SNOMEDCT_US_2016_03_01:189886003|SNOMEDCT_US_2016_03_01:443520009|UMLS_CUI:C0008479,primary chondrosarcoma of the bone|chondrosarcoma of bone,,disease_ontology,,DOID:3371,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,chondrosarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9563,"[""bronchiectasis""]",,"A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances.",false,,,http://purl.obolibrary.org/obo/DOID_1176,,,,,,,,"A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9563,,,DOID:9571|DOID:11047|DOID:11046,ICD10CM:J47|MESH:D001987|SNOMEDCT_US_2016_03_01:155580000|OMIM:613021|SNOMEDCT_US_2016_03_01:195986009|UMLS_CUI:C0006267|ICD9CM:494|ORDO:60033|ICD10CM:J47.9|NCI:C84475|SNOMEDCT_US_2016_03_01:12295008|OMIM:211400|OMIM:613071,Polynesian bronchiectasis,,disease_ontology,,DOID:9563,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,bronchiectasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200523,"[""TGFBR1 gene""]",,"The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400246,,,,,,,,"The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200523,,,,,,,,,,,,,,,,7046,TGFBR1,ALK5|SKR4,,,,,,,,,,TGFBR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000015,"[""ABL1(M351T) kinase domain""]",,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000015,,,,,,,,,,,,,,,,,,,200014,,,,,,,,,ABL1(M351T) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200563,"[""VRK2 gene""]",,"This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400243,,,,,,,,"This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200563,,,,,,,,,,,,,,,,7444,VRK2,,,,,,,,,,,VRK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300029,"[""Calcium-sensing receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300004,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300029,,,,,,,,,,,,,,,,,,,,,,,,,,,,Calcium-sensing receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000407,"[""osteosarcoma cell line""]",,Cell line of a malignant neoplasm of the bone-forming tissues.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000385,,,,,,,,Cell line of a malignant neoplasm of the bone-forming tissues.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000407,,,,,,,BrendaTissueOBO,osteogenic sarcoma cell line|osteoblastic sarcoma cell line,BTO:0000407,,,,,,,,,,,,,,,,,,,osteosarcoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200421,"[""OR52H1 gene""]",,"An olfactory receptor 52H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 52H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200421,,,,,,,,,,,,,,,,390067,OR52H1,,,,,,,,,,,OR52H1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000441,"[""TNNI3K kinase domain""]",,TNNI3 interacting kinase; CARK; HH498; MGC142099; MGC33828; TNNI3K,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,TNNI3 interacting kinase; CARK; HH498; MGC142099; MGC33828; TNNI3K,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000441,,,,,,,,,,,,,,,,,,,200442,,,,,,,,,TNNI3K kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11335,"[""sarcoidosis""]",,A hypersensitivity reaction type IV disease characterized by the growth of collections of inflammatory cells (granulomas) in multiple organs.,false,,,http://purl.obolibrary.org/obo/DOID_2916,,,,,,,,A hypersensitivity reaction type IV disease characterized by the growth of collections of inflammatory cells (granulomas) in multiple organs.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11335,,,,ICD10CM:D86.9|OMIM:181000|SNOMEDCT_US_2016_03_01:154425004|SNOMEDCT_US_2016_03_01:31541009|ICD9CM:135|OMIM:612388|OMIM:612387|NCI:C34995|UMLS_CUI:C0036202|ICD10CM:D80-D89|MESH:D012507|ICD10CM:D86|ORDO:797,lymphogranulomatosis|Boeck sarcoid,,disease_ontology,,DOID:11335,,,,,,,,,,,,,,,,,,,sarcoidosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11338,"[""tetanus""]",,"A primary bacterial infectious disease that results_in prolonged contraction of skeletal muscle fibers, has_material_basis_in Clostridium tetani, which produces tetanospasmin, a neurotoxin, which is carried to the brain and spinal cord, where it binds irreversibly to receptors inhibiting neurotransmission. Damaged upper motor neurons cannot control reflex responses to afferent sensory stimuli.",false,,,http://purl.obolibrary.org/obo/DOID_0050338,,,,,,,,"A primary bacterial infectious disease that results_in prolonged contraction of skeletal muscle fibers, has_material_basis_in Clostridium tetani, which produces tetanospasmin, a neurotoxin, which is carried to the brain and spinal cord, where it binds irreversibly to receptors inhibiting neurotransmission. Damaged upper motor neurons cannot control reflex responses to afferent sensory stimuli.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11338,,,,ICD9CM:037|MESH:D013742|SNOMEDCT_US_2016_03_01:76902006|ICD10CM:A35|SNOMEDCT_US_2016_03_01:276202003|UMLS_CUI:C0039614|NCI:C85185|SNOMEDCT_US_2016_03_01:154312006,Infection due to Clostridium tetani|clostridial tetanus,,disease_ontology,,DOID:11338,http://purl.obolibrary.org/obo/doid#gram-positive_bacterial_infectious_disease,,,,,,,,,,,,,,,,,,tetanus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000264,"[""PHE589 in TRKA""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000264,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE589 in TRKA,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000092,"[""trypanosomoid form""]",,"Any of a genus (Trypanosoma) of parasitic flagellate protozoans that infest the blood of various vertebrates including humans, are usually transmitted by the bite of an insect, and include some that cause serious disease (as sleeping sickness).",false,,,http://purl.obolibrary.org/obo/BTO_0002503|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Any of a genus (Trypanosoma) of parasitic flagellate protozoans that infest the blood of various vertebrates including humans, are usually transmitted by the bite of an insect, and include some that cause serious disease (as sleeping sickness).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000092,,,,,,,BrendaTissueOBO,trypanosomatid form|trypanid form,BTO:0000092,,,,,,,,,,,,,,,,,,,trypanosomoid form,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000772,"[""lymphoblast""]",,"Often referred to as a blast cell. Unlike other usages of the suffix -blast a lymphoblast is a further differentiation of a lymphocyte, T- or B-, occasioned by an antigenic stimulus. The lymphoblast usually develops by enlargement of a lymphocyte, active re-entry to the S phase of the cell cycle, mitogenesis and production of much m-RNA and ribosomes.",false,,,http://purl.obolibrary.org/obo/BTO_0000775|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Often referred to as a blast cell. Unlike other usages of the suffix -blast a lymphoblast is a further differentiation of a lymphocyte, T- or B-, occasioned by an antigenic stimulus. The lymphoblast usually develops by enlargement of a lymphocyte, active re-entry to the S phase of the cell cycle, mitogenesis and production of much m-RNA and ribosomes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000772,,,,,,,BrendaTissueOBO,,BTO:0000772,,,,,,,,,,,,,,,,,,,lymphoblast,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100164,"[""G protein-activated inward rectifier potassium channel 3""]",,"A G protein-activated inward rectifier potassium channel 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q92806] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300435,,,,,,,,"A G protein-activated inward rectifier potassium channel 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q92806] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100164,,,,https://pharos.nih.gov/idg/targets/Q92806,,,,,,,,,,,,,KCNJ9,GIRK3,,Q92806,,,,,,,,G protein-activated inward rectifier potassium channel 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300548,"[""Kv5.1/KCNF1 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300446,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300548,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv5.1/KCNF1 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001532,"[""rectal cancer cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001510,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001532,,,,,,,BrendaTissueOBO,rectal tumor cell line,BTO:0001532,,,,,,,,,,,,,,,,,,,rectal cancer cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100206,"[""Potassium voltage-gated channel subfamily H member 2""]",,"A voltage-gated potassium channel KCNH2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q12809] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300554,,,,,,,,"A voltage-gated potassium channel KCNH2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q12809] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100206,,,,https://pharos.nih.gov/idg/targets/Q12809,,,,,,,,,,,,,KCNH2,ERG|ERG1|HERG,,Q12809,,,,,,,,Potassium voltage-gated channel subfamily H member 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001415,"[""umbilical cord""]",,A cord arising from the navel that connects the fetus with the placenta.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A cord arising from the navel that connects the fetus with the placenta.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001415,,,,,,,BrendaTissueOBO,yolk stalk,BTO:0001415,,,,,,,,,,,,,,,,,,,umbilical cord,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10300,"[""Raynaud disease""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_341,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10300,,,,OMIM:179600|MESH:D011928|UMLS_CUI:C0034734|SNOMEDCT_US_2016_03_01:195295006|SNOMEDCT_US_2016_03_01:123266007|ICD10CM:I73.0|SNOMEDCT_US_2016_03_01:22954002,Raynaud's disease|Raynaud's syndrome NOS (disorder)|Raynaud's syndrome (disorder) [Ambiguous]|Raynaud's syndrome (disorder)|Raynaud's syndrome|Raynaud's disease (disorder),,disease_ontology,,DOID:10300,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Raynaud disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100122,"[""Gamma-aminobutyric acid receptor subunit rho-1""]",,"A gamma-aminobutyric acid receptor subunit rho-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P24046] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300521,,,,,,,,"A gamma-aminobutyric acid receptor subunit rho-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P24046] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100122,,,,https://pharos.nih.gov/idg/targets/P24046,,,,,,,,,,,,,GABRR1,,,P24046,,,,,,,,Gamma-aminobutyric acid receptor subunit rho-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400164,"[""IKK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400164,,,,,,,,,,,,,,,,,,,,,,,,,,,,IKK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004539,"[""connecting tubule""]",,"With respect to the renal corpuscle, the connecting tubule is the most proximal part of the collecting duct system. It is adjacent to the distal convoluted tubule, the most distal segment of the renal tubule. Connecting tubules from several adjacent nephrons merge to form cortical collecting tubules, and these may join to form cortical collecting ducts. Connecting tubules of some juxtamedullary nephrons may arch upward, forming an arcade. The connecting tubule derives from the metanephric blastema, but the rest of the system derives from the ureteric bud. Because of this, some sources group the connecting tubule as part of the nephron, rather than grouping it with the collecting duct system.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"With respect to the renal corpuscle, the connecting tubule is the most proximal part of the collecting duct system. It is adjacent to the distal convoluted tubule, the most distal segment of the renal tubule. Connecting tubules from several adjacent nephrons merge to form cortical collecting tubules, and these may join to form cortical collecting ducts. Connecting tubules of some juxtamedullary nephrons may arch upward, forming an arcade. The connecting tubule derives from the metanephric blastema, but the rest of the system derives from the ureteric bud. Because of this, some sources group the connecting tubule as part of the nephron, rather than grouping it with the collecting duct system.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004539,mgr,2010-02-16T10:31:31Z,,,,,BrendaTissueOBO,,BTO:0004539,,,,,,,,,,,,,,,,,,,connecting tubule,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300467,"[""Nav1.3/SCN3A subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300369,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300467,,,,,,,,,,,,,,,,,,,,,,,,,,,,Nav1.3/SCN3A subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002313,"[""immature cell""]",,Not fully grown or developed.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002322,,,,,,,,Not fully grown or developed.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002313,,,,,,,BrendaTissueOBO,,BTO:0002313,,,,,,,,,,,,,,,,,,,immature cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100348,"[""Olfactory receptor 13G1""]",,"An olfactory receptor 13G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 13G1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100348,,,,https://pharos.nih.gov/idg/targets/Q8NGZ3,,,,,,,,,,,,,OR13G1,,,Q8NGZ3,,,,,,,,Olfactory receptor 13G1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100197,"[""G-protein coupled receptor 42""]",,"A G-protein coupled receptor 42 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15529] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 42 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15529] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100197,,,,https://pharos.nih.gov/idg/targets/O15529,,,,,,,,,,,,,GPR42,GPR42P,,O15529,,,,,,,,G-protein coupled receptor 42,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300219,"[""ROR family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300219,,,,,,,,,,,,,,,,,,,,,,,,,,,,ROR family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000284,"[""organism form""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0000000|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000284,,,,,,,BrendaTissueOBO,Gestalt,BTO:0000284,,,,,,,,,,,,,,,,,,,organism form,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300506,"[""GABRA1 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300506,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRA1 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4448,"[""macular degeneration""]",,A retinal degeneration characterized by gradual deterioration of light-sensing cells in the tissues at the back of the eye and has_symptom vision loss.,false,,,http://purl.obolibrary.org/obo/DOID_8466,,,,,,,,A retinal degeneration characterized by gradual deterioration of light-sensing cells in the tissues at the back of the eye and has_symptom vision loss.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4448,,,,MESH:D057135|MESH:D008268|ORDO:279|UMLS_CUI:C0024437|NCI:C123330|SNOMEDCT_US_2016_03_01:302891003|SNOMEDCT_US_2016_03_01:422338006,Macular degeneration of retina,,disease_ontology,,DOID:4448,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,Xref MGI.,,macular degeneration,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400570,"[""KCa4.2/KCNT2 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400437,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400570,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCa4.2/KCNT2 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000422,"[""STK36 kinase domain""]",,"Serine/threonine kinase 36, fused homolog (Drosophila); DKFZp434N0223; FU; Fused; KIAA1278; STK36",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Serine/threonine kinase 36, fused homolog (Drosophila); DKFZp434N0223; FU; Fused; KIAA1278; STK36",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000422,,,,,,,,,,,,,,,,,,,200423,,,,,,,,,STK36 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200235,"[""PHKA2 gene""]",,"Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9A, also known as X-linked liver glycogenosis. Alternatively spliced transcript variants have been reported, but the full-length nature of these variants has not been determined.[provided by RefSeq, Feb 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03491039,,,,,,,,"Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9A, also known as X-linked liver glycogenosis. Alternatively spliced transcript variants have been reported, but the full-length nature of these variants has not been determined.[provided by RefSeq, Feb 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200235,,,,,,,,,,,,,,,,5256,PHKA2,PHKLA|PYK,,,,,,,,,,PHKA2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000204,"[""PHM""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000204,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHM,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100603,"[""Creatine kinase S-type, mitochondrial""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100603,,,,,,,,,,,,,,,,,CKMT2,,,P17540,,,,,,,,"Creatine kinase S-type, mitochondrial",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000347,"[""THR334 in FGR""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000347,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR334 in FGR,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3892,"[""insulinoma""]",,An adenoma that is located_in the pancreas and is characterized by overproduction of insulin.,false,,,http://purl.obolibrary.org/obo/DOID_657,,,,,,,,An adenoma that is located_in the pancreas and is characterized by overproduction of insulin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3892,,,DOID:3903,NCI:C95598|UMLS_CUI:C0022134|UMLS_CUI:C0021670|SNOMEDCT_US_2016_03_01:25324008|NCI:C65184|MESH:D007340|SNOMEDCT_US_2016_03_01:76345009|NCI:C3140|SNOMEDCT_US_2016_03_01:302822000|MESH:D007516|SNOMEDCT_US_2016_03_01:189586007|SNOMEDCT_US_2016_03_01:134154009,Insulin-Producing tumor of Islet cells|Islet cell adenoma,,disease_ontology,,DOID:3892,,,,,,,,,,,,,,,,,,,insulinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000349,"[""PIK3CA(M1043I) kinase domain""]",,"Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000349,,,,,,,,,,,,,,,,,,,200331,,,,,,,,,PIK3CA(M1043I) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1984,"[""rectal neoplasm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4610,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1984,,,,NCI:C3350|SNOMEDCT_US_2016_03_01:126847008|UMLS_CUI:C0034885|MESH:D012004,Rectal tumor|rectum neoplasm|neoplasm of rectum (disorder),,disease_ontology,,DOID:1984,,,,,,,,,,,,,,,,,,,rectal neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000207,"[""tibial cartilage""]",,Cartilage pertaining to the tibia.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000206|http://purl.obolibrary.org/obo/BTO_0001252,,,,,,,,Cartilage pertaining to the tibia.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000207,,,,,,,BrendaTissueOBO,,BTO:0000207,,,,,,,,,,,,,,,,,,,tibial cartilage,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4933,"[""apocrine adenocarcinoma""]",,An apocrine sweat gland cancer that derives_from epithelial cells of glandular origin.,false,,,http://purl.obolibrary.org/obo/DOID_5667|http://purl.obolibrary.org/obo/DOID_4934,,,,,,,,An apocrine sweat gland cancer that derives_from epithelial cells of glandular origin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4933,,,DOID:5571,SNOMEDCT_US_2016_03_01:57141000|UMLS_CUI:C0334346,Apocrine carcinoma|carcinoma of the Apocrine gland|Apocrine adenocarcinoma (morphologic abnormality)|apocrine gland carcinoma,,disease_ontology,,DOID:4933,,,,,,,,,,,,,,,,,,,apocrine adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200346,"[""OR13D1 gene""]",,"An olfactory receptor 13D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGV5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 13D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGV5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200346,,,,,,,,,,,,,,,,286365,OR13D1,,,,,,,,,,,OR13D1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100633,"[""Pantothenate kinase 2, mitochondrial""]",,"A pantothenate kinase 2, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BZ23] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391028,,,,,,,,"A pantothenate kinase 2, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BZ23] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100633,,,,https://pharos.nih.gov/idg/targets/Q9BZ23,,,,,,,,,,,,,PANK2,,,Q9BZ23,,,,,,,,"Pantothenate kinase 2, mitochondrial",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100802,"[""Trace amine-associated receptor 2""]",,"A trace amine-associated receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9P1P5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A trace amine-associated receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9P1P5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100802,,,,https://pharos.nih.gov/idg/targets/Q9P1P5,,,,,,,,,,,,,TAAR2,GPR58,,Q9P1P5,,,,,,,,Trace amine-associated receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200589,"[""OR4F6 gene""]",,"An olfactory receptor 4F6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4F6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200589,,,,,,,,,,,,,,,,390648,OR4F6,OR4F12,,,,,,,,,,OR4F6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00000004,"[""drug target""]",,"A material entity, such as native (gene product) protein, protein complex, microorganism, DNA , etc., that physically interacts with a therapeutic or prophylactic drug (with some binding affinity) and where this physical interaction is (at least partially) the cause of a (detectable) clinical effect.",false,,,http://www.w3.org/2002/07/owl#Thing,,,,,,,,"A material entity, such as native (gene product) protein, protein complex, microorganism, DNA , etc., that physically interacts with a therapeutic or prophylactic drug (with some binding affinity) and where this physical interaction is (at least partially) the cause of a (detectable) clinical effect.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00000004,,,,,,,,,,,,,,,,,,,,,,,,,,,"Tudor Oprea, Stephan Schurer, Asiyah Yu Lin",drug target,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400451,"[""V subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400451,,,,,,,,,,,,,,,,,,,,,,,,,,,,V subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001169,"[""3T3-F442A cell""]",,Preadipocyte cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000746,,,,,,,,Preadipocyte cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001169,,,,,,,BrendaTissueOBO,F442A cell|3T3-442A cell,BTO:0001169,,,,,,,,,,,,,,,,,,,3T3-F442A cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11996,"[""spermatic cord torsion""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2519,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11996,,,,ICD10CM:N44.0|ICD9CM:608.20|ICD10CM:N44.02|ICD9CM:608.2|SNOMEDCT_US_2016_03_01:198046000|OMIM:187400|NCI:C26885|ICD10CM:N44.00|SNOMEDCT_US_2016_03_01:81996005|UMLS_CUI:C0037856|SNOMEDCT_US_2016_03_01:198045001|SNOMEDCT_US_2016_03_01:155937003|SNOMEDCT_US_2016_03_01:198048004|SNOMEDCT_US_2016_03_01:49198006|MESH:D013086,Torsion of testicle|Torsion of testis|testicular Torsion,,disease_ontology,,DOID:11996,,,,,,,,,,,,,,,,,,,spermatic cord torsion,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200490,"[""STK17B gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400146,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200490,,,,,,,,,,,,,,,,9262,STK17B,DRAK2,,,,,,,,,,STK17B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100249,"[""Leukotriene B4 receptor 2""]",,"A leukotriene B4 receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NPC1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300033,,,,,,,,"A leukotriene B4 receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NPC1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100249,,,,https://pharos.nih.gov/idg/targets/Q9NPC1,,,,,,,,,,,,,LTB4R2,BLT2R|BLTR2,,Q9NPC1,,,,,,,,Leukotriene B4 receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000160,"[""Wnt-5a""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000160,,,,,,,,,,,,,,,,,,,,,,,,,,,,Wnt-5a,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001454,"[""thymoma cell""]",,Thymoma is a disease in which cancer (malignant) cells are found in the tissues of the thymus. Thymoma is usually a slow-growing tumor that does not spread beyond the thymus.,false,,,http://purl.obolibrary.org/obo/BTO_0001460|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Thymoma is a disease in which cancer (malignant) cells are found in the tissues of the thymus. Thymoma is usually a slow-growing tumor that does not spread beyond the thymus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001454,,,,,,,BrendaTissueOBO,,BTO:0001454,,,,,,,,,,,,,,,,,,,thymoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001229,"[""IMR-90 cell""]",,Normal lung fibroblast cell line from a human female. The human diploid fibroblast strain IMR-90 was derived by W.W. Nichols and associates from the lungs of a 16-week female fetus.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000161|http://purl.obolibrary.org/obo/BTO_0001242,,,,,,,,Normal lung fibroblast cell line from a human female. The human diploid fibroblast strain IMR-90 was derived by W.W. Nichols and associates from the lungs of a 16-week female fetus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001229,,,,,,,BrendaTissueOBO,,BTO:0001229,,,,,,,,,,,,,,,,,,,IMR-90 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4110,"[""parasitic ectoparasitic infectious disease""]",,A parasitic infectious disease that is caused by organisms that live primarily on the surface of the host.,false,,,http://purl.obolibrary.org/obo/DOID_1398,,,,,,,,A parasitic infectious disease that is caused by organisms that live primarily on the surface of the host.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4110,,,,MESH:D004478|UMLS_CUI:C0013578,ectoparasitism,,disease_ontology,,DOID:4110,,,,,,,,,,,,,,,,,,,parasitic ectoparasitic infectious disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000171,"[""NCI-H226Br cell""]",,The H226Br cell line is a variant of the NCI-H226 cell line derived from a brain metastasis in a nu/nu mouse.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The H226Br cell line is a variant of the NCI-H226 cell line derived from a brain metastasis in a nu/nu mouse.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000171,Marion,2014-03-03T20:51:18Z,,,,,BrendaTissueOBO,H226Br cell|H-226Br cell,BTO:0000171,,,,,,,,,,,,,,,,,,,NCI-H226Br cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100045,"[""Bone morphogenetic protein receptor type-1b""]",,"bone morphogenetic protein receptor type-1b (BMPR1B)  with  no mutation  in a nonphosphorylated state|A BMP receptor type-1B that is encoded in the genome of human. [PRO:CNA, UniProtKB:O00238] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300246,,,,,,,,"bone morphogenetic protein receptor type-1b (BMPR1B)  with  no mutation  in a nonphosphorylated state|A BMP receptor type-1B that is encoded in the genome of human. [PRO:CNA, UniProtKB:O00238] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100045,,,,https://pharos.nih.gov/idg/targets/O00238,,,,,,,,,,,,,BMPR1B,,,O00238,,,,,,,,Bone morphogenetic protein receptor type-1b,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000229,"[""CXCL9""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000229,,,,,,,,,,,,,,,,,,,,,,,,,,,,CXCL9,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000257,"[""PHE267 in PCTK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000257,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE267 in PCTK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001739,"[""pars tuberalis""]",,A thin plate of cells that is an extension of the adenohypophysis on the ventral or anterior aspect of the infundibulum.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A thin plate of cells that is an extension of the adenohypophysis on the ventral or anterior aspect of the infundibulum.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001739,,,,,,,BrendaTissueOBO,,BTO:0001739,,,,,,,,,,,,,,,,,,,pars tuberalis,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200542,"[""TSSK3 gene""]",,"This gene encodes a kinase expressed exclusively in the testis that is thought to play a role in either germ cell differentiation or mature sperm function. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400238,,,,,,,,"This gene encodes a kinase expressed exclusively in the testis that is thought to play a role in either germ cell differentiation or mature sperm function. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200542,,,,,,,,,,,,,,,,81629,TSSK3,SPOGA3|STK22C,,,,,,,,,,TSSK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300566,"[""Kv9.1/KCNS1 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300450,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300566,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv9.1/KCNS1 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80254,"[""Melanin-concentrating hormone""]",MCH,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG COMPOUND:67382-96-1|KEGG COMPOUND:C16030,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,MCH,,,CHEBI:80254,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80254,,,,,Melanin-concentrating hormone,,CHEBI:80254,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200395,"[""PDK1 gene""]",,"Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400131,,,,,,,,"Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200395,,,,,,,,,,,,,,,,5163,PDK1,PDHK1,,,,,,,,,,PDK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400477,"[""SCNN1A subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400330,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400477,,,,,,,,,,,,,,,,,,,,,,,,,,,,SCNN1A subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9268,"[""glycine encephalopathy""]",,An amino acid metabolic disorder that involves abnormally high levels of the amino acid glycine in bodily fluids and tissues.,false,,,http://purl.obolibrary.org/obo/DOID_9252,,,,,,,,An amino acid metabolic disorder that involves abnormally high levels of the amino acid glycine in bodily fluids and tissues.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9268,,,,OMIM:605899|ICD10CM:E72.51|NCI:C84937|MESH:D020158|UMLS_CUI:C0751748|SNOMEDCT_US_2016_03_01:237939006,Non-ketotic hyperglycinemia (disorder)|Non-ketotic hyperglycinemia |nonketotic hyperglycinemia,,disease_ontology,,DOID:9268,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,glycine encephalopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001586,"[""lymphoid cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001586,,,,,,,BrendaTissueOBO,,BTO:0001586,,,,,,,,,,,,,,,,,,,lymphoid cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100127,"[""Ephrin type-a receptor 3""]",,"ephrin type-a receptor 3 (EPHA3)  with  no mutation  in a nonphosphorylated state|An ephrin type-A receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P29320] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300153,,,,,,,,"ephrin type-a receptor 3 (EPHA3)  with  no mutation  in a nonphosphorylated state|An ephrin type-A receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P29320] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100127,,,,https://pharos.nih.gov/idg/targets/P29320,,,,,,,,,,,,,EPHA3,ETK|ETK1|HEK|TYRO4,,P29320,,,,,,,,Ephrin type-a receptor 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100569,"[""Olfactory receptor 4C3""]",,"An olfactory receptor 4C3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH37] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4C3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH37] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100569,,,,https://pharos.nih.gov/idg/targets/Q8NH37,,,,,,,,,,,,,OR4C3,,,Q8NH37,,,,,,,,Olfactory receptor 4C3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100620,"[""Ribose-phosphate pyrophosphokinase 3""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100620,,,,,,,,,,,,,,,,,PRPS1L1,,,P21108,,,,,,,,Ribose-phosphate pyrophosphokinase 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200218,"[""KCNK6 gene""]",,"This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400359,,,,,,,,"This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200218,,,,,,,,,,,,,,,,9424,KCNK6,TOSS|TWIK2,,,,,,,,,,KCNK6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200433,"[""PLK4 gene""]",,"This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400211,,,,,,,,"This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200433,,,,,,,,,,,,,,,,10733,PLK4,SAK|STK18,,,,,,,,,,PLK4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050820,"[""atrioventricular block""]",,A heart conduction disease that is characterized by the impairment of the conduction between the atria and ventricles of the heart.,false,,,http://purl.obolibrary.org/obo/DOID_10273,,,,,,,,A heart conduction disease that is characterized by the impairment of the conduction between the atria and ventricles of the heart.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050820,lschriml,2014-02-12T01:35:05Z,,ICD9CM:426.10|SNOMEDCT_US_2016_03_01:233917008|MESH:D054537|UMLS_CUI:C0004245|NCI:C26703|ICD10CM:I44.30|SNOMEDCT_US_2016_03_01:195043007|SNOMEDCT_US_2016_03_01:195040005|ICD10CM:I44.3|SNOMEDCT_US_2016_03_01:58547007,AV block,,disease_ontology,,DOID:0050820,,,,,,,,,,,,,,,,,,,atrioventricular block,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050826,"[""tricuspid valve disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4079,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050826,lschriml,2014-02-12T02:55:24Z,DOID:13834,ICD10CM:I07.9|SNOMEDCT_US_2016_03_01:266282000|SNOMEDCT_US_2016_03_01:49699002|UMLS_CUI:C0264776|ICD9CM:397.0|ICD10CM:I07|SNOMEDCT_US_2016_03_01:155289000|SNOMEDCT_US_2016_03_01:194745002,disease of tricuspid valve|Rheumatic tricuspid valve disease NOS (disorder)|rheumatic tricuspid valve disease|RH. tricuspid valve disease|Rheumatic disease of tricuspid valve (disorder)|Tricuspid disease,,disease_ontology,,DOID:0050826,,,,,,,,,,,,,,,,,,,tricuspid valve disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050824,"[""sinoatrial node disease""]",,A heart conduction disease that is characterized by dysfunction of the impulse-generating (pacemaker) tissue located in the right atrium of the heart which generates normal sinus rhythm.,false,,,http://purl.obolibrary.org/obo/DOID_66|http://purl.obolibrary.org/obo/DOID_10273,,,,,,,,A heart conduction disease that is characterized by dysfunction of the impulse-generating (pacemaker) tissue located in the right atrium of the heart which generates normal sinus rhythm.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050824,lschriml,2014-02-12T01:47:54Z,,,SA node|sinuatrial node,,disease_ontology,,DOID:0050824,,,,,,,,,,,,,,,,,,,sinoatrial node disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050828,"[""artery disease""]",,A vascular disease that is located_in an artery.,false,,,http://purl.obolibrary.org/obo/DOID_178,,,,,,,,A vascular disease that is located_in an artery.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050828,lschriml,2014-02-12T03:08:35Z,,,,,disease_ontology,,DOID:0050828,,,,,,,,,,,,,,,,,,,artery disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050829,"[""pericardium disease""]",,A cardiovascular system disease that is located_in the  fibrous sac surrounding the heart.,false,,,http://purl.obolibrary.org/obo/DOID_1287,,,,,,,,A cardiovascular system disease that is located_in the  fibrous sac surrounding the heart.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050829,lschriml,2014-02-18T12:20:15Z,,,,,disease_ontology,,DOID:0050829,,,,,,,,,,,,,,,,,,,pericardium disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050825,"[""endocardium disease""]",,A heart disease that is located_in the innermost layer of tissue that lines the chambers of the heart.,false,,,http://purl.obolibrary.org/obo/DOID_114,,,,,,,,A heart disease that is located_in the innermost layer of tissue that lines the chambers of the heart.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050825,lschriml,2014-02-12T01:53:42Z,,,,,disease_ontology,,DOID:0050825,,,,,,,,,,,,,,,,,,,endocardium disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200415,"[""OR52E1 gene""]",,"An olfactory receptor 52E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 52E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200415,,,,,,,,,,,,,,,,79296,OR52E1,OR52E1P,,,,,,,,,,OR52E1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005587,"[""stalk cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005587,Marion,2014-03-05T19:59:34Z,,,,,BrendaTissueOBO,,BTO:0005587,,,,,,,,,,,,,,,,,,,stalk cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001113,"[""prepuce""]",,A fold of skin that covers the glans of the penis.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A fold of skin that covers the glans of the penis.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001113,,,,,,,BrendaTissueOBO,foreskin,BTO:0001113,,,,,,,,,,,,,,,,,,,prepuce,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200573,"[""OR4C12 gene""]",,"An olfactory receptor 4C12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R67] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4C12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R67] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200573,,,,,,,,,,,,,,,,283093,OR4C12,,,,,,,,,,,OR4C12 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400052,"[""Melanin-concentrating hormone receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400052,,,,,,,,,,,,,,,,,,,,,,,,,,,,Melanin-concentrating hormone receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050117,"[""disease by infectious agent""]",,"A disease that is the consequence of the presence of pathogenic microbial agents, including pathogenic viruses, pathogenic bacteria, fungi, protozoa, multicellular parasites, and aberrant proteins known as prions.",false,,,http://purl.obolibrary.org/obo/DOID_4,,,,,,,,"A disease that is the consequence of the presence of pathogenic microbial agents, including pathogenic viruses, pathogenic bacteria, fungi, protozoa, multicellular parasites, and aberrant proteins known as prions.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050117,,,DOID:1321|DOID:4620|DOID:11078|DOID:95|DOID:1304|DOID:2040|DOID:9532|DOID:2288|DOID:3099|DOID:9696|DOID:945|DOID:10115|DOID:4120|DOID:5256,UMLS_CUI:C0001485|ICD9CM:079.0,infectious disease,,disease_ontology,,DOID:0050117,http://purl.obolibrary.org/obo/doid#DO_MGI_slim|http://purl.obolibrary.org/obo/doid#NCIthesaurus,,,,,,,,,,,,,,,,,,disease by infectious agent,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050118,"[""La Crosse encephalitis""]",,"A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in La Crosse virus, which is transmitted_by treehole mosquito, Ochlerotatus triseriatus. The infection has_symptom seizures, has_symptom headache, has_symptom fever, has_symptom coma, and has_symptom paralysis.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in La Crosse virus, which is transmitted_by treehole mosquito, Ochlerotatus triseriatus. The infection has_symptom seizures, has_symptom headache, has_symptom fever, has_symptom coma, and has_symptom paralysis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050118,,,DOID:10840,MESH:D004670|ICD9CM:062.5|SNOMEDCT_US_2016_03_01:418531007|SNOMEDCT_US_2016_03_01:266103004|ICD10CM:A83.5|UMLS_CUI:C0014053|SNOMEDCT_US_2016_03_01:69627004|SNOMEDCT_US_2016_03_01:416442006|SNOMEDCT_US_2016_03_01:417075004|SNOMEDCT_US_2016_03_01:186588007,California Encephalitis|California virus encephalitis|Neuroinvasive California encephalitis virus infection,,disease_ontology,,DOID:0050118,http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,La Crosse encephalitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100301,"[""Sodium channel protein type 10 subunit alpha""]",,"A sodium channel protein type 10 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5Y9] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300475,,,,,,,,"A sodium channel protein type 10 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5Y9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100301,,,,https://pharos.nih.gov/idg/targets/Q9Y5Y9,,,,,,,,,,,,,SCN10A,,,Q9Y5Y9,,,,,,,,Sodium channel protein type 10 subunit alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100498,"[""Olfactory receptor 1l4""]",,"An olfactory receptor 1L4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1L4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100498,,,,https://pharos.nih.gov/idg/targets/Q8NGR5,,,,,,,,,,,,,OR1L4,OR1L5,,Q8NGR5,,,,,,,,Olfactory receptor 1l4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100511,"[""Olfactory receptor 2a5""]",,"An olfactory receptor 2A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R48] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R48] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100511,,,,https://pharos.nih.gov/idg/targets/Q96R48,,,,,,,,,,,,,OR2A5,OR2A26|OR2A8,,Q96R48,,,,,,,,Olfactory receptor 2a5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9220,"[""central sleep apnea""]",,"A sleep apnea that is characterized by a malfunction of the basic neurological controls for breathing rate and the failure to give the signal to inhale, causing the individual to miss one or more cycles of breathing.",false,,,http://purl.obolibrary.org/obo/DOID_0050847,,,,,,,,"A sleep apnea that is characterized by a malfunction of the basic neurological controls for breathing rate and the failure to give the signal to inhale, causing the individual to miss one or more cycles of breathing.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9220,,,,MESH:D020182|OMIM:207720|ICD10CM:G47.31|OMIM:107640|ICD9CM:327.21|SNOMEDCT_US_2016_03_01:9741000119101|UMLS_CUI:C0751762,primary central sleep apnea,,disease_ontology,central sleep apnea syndrome,DOID:9220,,,,,,,,,,,,,,,,,Xref MGI.,,central sleep apnea,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200196,"[""KCNE1 gene""]",,"The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400445,,,,,,,,"The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200196,,,,,,,,,,,,,,,,3753,KCNE1,,,,,,,,,,,KCNE1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000041,"[""AMPK-alpha1 kinase domain""]",,"Protein kinase, AMP-activated, alpha 2 catalytic subunit; AMPK; AMPKa1; AMPK-alpha1; MGC33776; MGC57364; PRKAA1",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Protein kinase, AMP-activated, alpha 2 catalytic subunit; AMPK; AMPKa1; AMPK-alpha1; MGC33776; MGC57364; PRKAA1",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000041,,,,,,,,,,,,,,,,,,,200038,,,,,,,,,AMPK-alpha1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14247,"[""chronic purulent otitis media""]",,A suppurative otitis media which is persistent and long-lasting.,false,,,http://purl.obolibrary.org/obo/DOID_11506,,,,,,,,A suppurative otitis media which is persistent and long-lasting.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14247,,,,SNOMEDCT_US_2016_03_01:232253005|SNOMEDCT_US_2016_03_01:155228005|ICD10CM:H66.3|SNOMEDCT_US_2016_03_01:194284006|ICD9CM:382.3|UMLS_CUI:C0271454|SNOMEDCT_US_2016_03_01:38394007,chronic suppurative otitis media,,disease_ontology,,DOID:14247,,,,,,,,,,,,,,,,,,,chronic purulent otitis media,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400411,"[""GRIA2 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400411,,,,,,,,,,,,,,,,,,,,,,,,,,,,GRIA2 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200566,"[""OR4A5 gene""]",,"An olfactory receptor 4A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH83] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH83] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200566,,,,,,,,,,,,,,,,81318,OR4A5,,,,,,,,,,,OR4A5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100491,"[""Olfactory receptor 1I1""]",,"An olfactory receptor 1I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60431] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60431] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100491,,,,https://pharos.nih.gov/idg/targets/O60431,,,,,,,,,,,,,OR1I1,,,O60431,,,,,,,,Olfactory receptor 1I1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8712,"[""neurofibromatosis""]",,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8712,,,DOID:14750|DOID:9137|DOID:8711,ICD9CM:237.7|UMLS_CUI:C0027831|ICD9CM:237.70|SNOMEDCT_US_2016_03_01:154642000|SNOMEDCT_US_2016_03_01:700060008|SNOMEDCT_US_2016_03_01:92503002|SNOMEDCT_US_2016_03_01:19133005|MESH:D017253|MESH:D016518|ORDO:93921|OMIM:101000|NCI:C6727|ICD9CM:237.72|ORDO:636|NCI:C3274|MESH:C537392|OMIM:162210|ICD9CM:237.71|SNOMEDCT_US_2016_03_01:81669005|OMIM:162200|ICD10CM:Q85.01|OMIM:162260|MESH:D009456|ICD10CM:Q85.00|SNOMEDCT_US_2016_03_01:700061007|SNOMEDCT_US_2016_03_01:92824003|ORDO:637|ICD10CM:Q85.02|OMIM:162270|UMLS_CUI:C0162678|UMLS_CUI:C0027832|NCI:C3273|UMLS_CUI:C0220695,von Reklinghausen disease|neurofibromatosis type 2|Acoustic neurofibromatosis|central Neurofibromatosis|neurofibromatosis type 4|Neurofibromatosis 1|Recklinghausen's neurofibromatosis|neurofibromatosis type 1|type IV neurofibromatosis of riccardi|peripheral Neurofibromatosis|neurofibromatosis type IV ,,disease_ontology,,DOID:8712,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,neurofibromatosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100142,"[""Probable g-protein coupled receptor 132""]",,"A G-protein coupled receptor 132 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UNW8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 132 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UNW8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100142,,,,https://pharos.nih.gov/idg/targets/Q9UNW8,,,,,,,,,,,,,GPR132,G2A,,Q9UNW8,,,,,,,,Probable g-protein coupled receptor 132,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001657,"[""abscission zone""]",,"The region at the base of a leaf, flower, fruit, or other plant part, where the formation of a cork layer results in the separation of that part from the plant body.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The region at the base of a leaf, flower, fruit, or other plant part, where the formation of a cork layer results in the separation of that part from the plant body.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001657,,,,,,,BrendaTissueOBO,abscission layer|separation layer,BTO:0001657,,,,,,,,,,,,,,,,,,,abscission zone,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000064,"[""LEU176 in SGK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000064,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU176 in SGK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10534,"[""stomach cancer""]",,A gastrointestinal system cancer that is located_in the stomach.,false,,,http://purl.obolibrary.org/obo/DOID_3119|http://purl.obolibrary.org/obo/DOID_76,,,,,,,,A gastrointestinal system cancer that is located_in the stomach.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10534,,,DOID:4713|DOID:10543|DOID:10542|DOID:10539,ICD10CM:C16.5|UMLS_CUI:C0153421|SNOMEDCT_US_2016_03_01:187750004|UMLS_CUI:C0038356|SNOMEDCT_US_2016_03_01:187744009|ICD9CM:151.6|SNOMEDCT_US_2016_03_01:154452009|SNOMEDCT_US_2016_03_01:187731004|ICD10CM:C16.2|UMLS_CUI:C0153423|SNOMEDCT_US_2016_03_01:94074003|SNOMEDCT_US_2016_03_01:187742008|SNOMEDCT_US_2016_03_01:93818001|ICD9CM:151.5|ICD9CM:151.9|ICD10CM:C16.9|OMIM:613659|SNOMEDCT_US_2016_03_01:154453004|SNOMEDCT_US_2016_03_01:269532005|OMIM:137215|SNOMEDCT_US_2016_03_01:269529007|NCI:C3387|SNOMEDCT_US_2016_03_01:93717002|NCI:C9331|SNOMEDCT_US_2016_03_01:154451002|SNOMEDCT_US_2016_03_01:93867004|SNOMEDCT_US_2016_03_01:154450001|ICD9CM:151.4|SNOMEDCT_US_2016_03_01:363349007|ICD9CM:151|SNOMEDCT_US_2016_03_01:255080008|SNOMEDCT_US_2016_03_01:269460009|UMLS_CUI:C0153422|SNOMEDCT_US_2016_03_01:126824007|MESH:D013274|UMLS_CUI:C0024623|SNOMEDCT_US_2016_03_01:269459004|SNOMEDCT_US_2016_03_01:187743003|SNOMEDCT_US_2016_03_01:269531003|ICD10CM:C16.6|SNOMEDCT_US_2016_03_01:269458007|SNOMEDCT_US_2016_03_01:269530002|ICD10CM:C16,malignant tumor of lesser curve of stomach (disorder)|Ca body - stomach|malignant tumor of greater curve of stomach (disorder)|gastric neoplasm|ca greater curvature of stomach|malignant neoplasm of body of stomach|malignant neoplasm of lesser curve of stomach unspecified (disorder)|malignant tumor of body of stomach (disorder)|Ca lesser curvature - stomach (disorder),,disease_ontology,,DOID:10534,http://purl.obolibrary.org/obo/doid#DO_cancer_slim|http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,stomach cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_32952,"[""amine""]",Amin|an amine|.|Substituted amine|N[*],"A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.|
A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.
",false,,,http://purl.obolibrary.org/obo/CHEBI_23367,,,,,,,KEGG COMPOUND:C00706|KEGG:C00706,"A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.|
A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:13814|CHEBI:2641|CHEBI:22474,,amines|Amine,,chebi_ontology,Amin|an amine|.|Substituted amine|N[*],,,CHEBI:32952,,,,,,,,,,,,,,,,,,,,,,,CHEBI:32952,,,,,amine|Amine,,CHEBI:32952,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001705,"[""vallate papilla""]",,"The largest papilla of the tongue, 8 to 12 in number, arranged in the form of a V anterior to the sulcus terminalis of the tongue.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The largest papilla of the tongue, 8 to 12 in number, arranged in the form of a V anterior to the sulcus terminalis of the tongue.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001705,,,,,,,BrendaTissueOBO,papilla vallatae|circumvallate papilla,BTO:0001705,,,,,,,,,,,,,,,,,,,vallate papilla,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3981,"[""pantothenate kinase-associated neurodegeneration""]",,A neurodegeneration with brain iron accumulation that has_material_basis_in autosomal recessive inheritance of mutation in the PANK2 gene on chromosome 20p13. ,false,,,http://purl.obolibrary.org/obo/DOID_0110734,,,,,,,,A neurodegeneration with brain iron accumulation that has_material_basis_in autosomal recessive inheritance of mutation in the PANK2 gene on chromosome 20p13. ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3981,,,,MESH:D006211|ICD10CM:G23.0|NCI:C84988|NCI:C8967|UMLS_CUI:C0018523|OMIM:234200|SNOMEDCT_US_2016_03_01:2992000,Hallervorden-Spatz disease|Pigmentary pallidal degeneration (disorder)|brain Iron Accumulation type I syndrome|NBIA1|neurodegeneration with brain iron accumulation 1 |Hallervorden-Spatz syndrome,,disease_ontology,,DOID:3981,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,pantothenate kinase-associated neurodegeneration,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001242,"[""fetal cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001242,,,,,,,BrendaTissueOBO,,BTO:0001242,,,,,,,,,,,,,,,,,,,fetal cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200258,"[""RPS6KB2 gene""]",,"This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400282,,,,,,,,"This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200258,,,,,,,,,,,,,,,,6199,RPS6KB2,STK14B,,,,,,,,,,RPS6KB2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005403,"[""glycogen cell""]",,"The junctional zone of the mouse placenta consists of two main trophoblast populations, spongiotrophoblasts and glycogen cells (GCs), but the development and function of both cell types are unknown.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The junctional zone of the mouse placenta consists of two main trophoblast populations, spongiotrophoblasts and glycogen cells (GCs), but the development and function of both cell types are unknown.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005403,XPMUser,2012-09-04T11:41:51Z,,,,,BrendaTissueOBO,,BTO:0005403,,,,,,,,,,,,,,,,,,,glycogen cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200064,"[""CELSR1 gene""]",,"A cadherin EGF LAG seven-pass G-type receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYQ6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400032,,,,,,,,"A cadherin EGF LAG seven-pass G-type receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYQ6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200064,,,,,,,,,,,,,,,,9620,CELSR1,CDHF9|FMI2,,,,,,,,,,CELSR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1382,"[""miliaria""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1383,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1382,,,,MESH:D008883|SNOMEDCT_US_2016_03_01:201196009|NCI:C34820|UMLS_CUI:C0026113|SNOMEDCT_US_2016_03_01:63951004|ICD10CM:L74.3|SNOMEDCT_US_2016_03_01:201411009,,,disease_ontology,,DOID:1382,,,,,,,,,,,,,,,,,,,miliaria,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200356,"[""OR14K1 gene""]",,"An olfactory receptor 14K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 14K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200356,,,,,,,,,,,,,,,,343170,OR14K1,OR5AY1,,,,,,,,,,OR14K1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000031,"[""ACVR2B kinase domain""]",,"Activin A receptor, type IIB; ActR2B; ACTRIIB; ActR-IIB; ACVR2B; MGC116908",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Activin A receptor, type IIB; ActR2B; ACTRIIB; ActR-IIB; ACVR2B; MGC116908",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000031,,,,,,,,,,,,,,,,,,,200030,,,,,,,,,ACVR2B kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400036,"[""Corticotropin-releasing factor receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400003,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400036,,,,,,,,,,,,,,,,,,,,,,,,,,,,Corticotropin-releasing factor receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004147,"[""lumbar spine""]",,That portion of the spine comprising the lumbar vertebrae.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,That portion of the spine comprising the lumbar vertebrae.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004147,,,,,,,BrendaTissueOBO,,BTO:0004147,,,,,,,,,,,,,,,,,,,lumbar spine,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100069,"[""Chemokine-like receptor 1""]",,"A chemokine receptor-like protein CMKLR1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99788] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300034,,,,,,,,"A chemokine receptor-like protein CMKLR1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99788] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100069,,,,https://pharos.nih.gov/idg/targets/Q99788,,,,,,,,,,,,,CMKLR1,CHEMR23|DEZ,,Q99788,,,,,,,,Chemokine-like receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300595,"[""TRPV6 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300484,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300595,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPV6 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003150,"[""pulmonary artery endothelial cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003150,,,,,,,BrendaTissueOBO,,BTO:0003150,,,,,,,,,,,,,,,,,,,pulmonary artery endothelial cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200240,"[""KCNT1 gene""]",,"Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400569,,,,,,,,"Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200240,,,,,,,,,,,,,,,,57582,KCNT1,KIAA1422,,,,,,,,,,KCNT1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001379,"[""thyroid gland""]",,"A two-lobed endocrine gland found in all vertebrates, located in front of and on either side of the trachea in humans, and producing various hormones, such as triiodothyronine and calcitonin.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062|http://purl.obolibrary.org/obo/BTO_0001488,,,,,,,,"A two-lobed endocrine gland found in all vertebrates, located in front of and on either side of the trachea in humans, and producing various hormones, such as triiodothyronine and calcitonin.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001379,,,,,,,BrendaTissueOBO,thyroid,BTO:0001379,,,,,,,,,,,,,,,,,,,thyroid gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100788,"[""Taste receptor type 2 member 42""]",,"A taste receptor type 2 member 42 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7RTR8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300014,,,,,,,,"A taste receptor type 2 member 42 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7RTR8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100788,,,,https://pharos.nih.gov/idg/targets/Q7RTR8,,,,,,,,,,,,,TAS2R42,TAS2R55,,Q7RTR8,,,,,,,,Taste receptor type 2 member 42,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100023,"[""Anoctamin-2""]",,"An anoctamin-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NQ90] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300329,,,,,,,,"An anoctamin-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NQ90] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100023,,,,https://pharos.nih.gov/idg/targets/Q9NQ90,,,,,,,,,,,,,ANO2,C12orf3|TMEM16B,,Q9NQ90,,,,,,,,Anoctamin-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001560,"[""testicular cancer cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0004229,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001560,,,,,,,BrendaTissueOBO,,BTO:0001560,,,,,,,,,,,,,,,,,,,testicular cancer cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200111,"[""GABRA5 gene""]",,"GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400510,,,,,,,,"GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200111,,,,,,,,,,,,,,,,2558,GABRA5,,,,,,,,,,,GABRA5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4080,"[""tricuspid valve insufficiency""]",,"A tricuspid valve disease that is characterized by failure of the heart's tricuspid valve to close properly during systole. As a result, with each heart beat, blood is pumped out from the right side of the heart in the opposite direction to normal.",false,,,http://purl.obolibrary.org/obo/DOID_0050826,,,,,,,,"A tricuspid valve disease that is characterized by failure of the heart's tricuspid valve to close properly during systole. As a result, with each heart beat, blood is pumped out from the right side of the heart in the opposite direction to normal.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4080,,,,NCI:C50843|NCI:C50842|SNOMEDCT_US_2016_03_01:251009000|SNOMEDCT_US_2016_03_01:266298007|SNOMEDCT_US_2016_03_01:155347006|MESH:D014262|UMLS_CUI:C0040961|SNOMEDCT_US_2016_03_01:111287006,Tricuspid valve regurgitation (disorder)|Tricuspid incompetence|Tricuspid regurgitation,,disease_ontology,,DOID:4080,,,,,,,,,,,,,,,,,,,tricuspid valve insufficiency,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491011,"[""Pyridoxine kinase family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400324,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491011,,,,,,,,,,,,,,,,,,,,,,,,,,,,Pyridoxine kinase family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000731,"[""acute lymphoblastic leukemia cell""]",,"Lymphocytic leukemia cell that is marked by an abnormal increase in the number of lymphoblasts, that is characterized by rapid onset and progression of symptoms which include fever, anemia, pallor, fatigue, appetite loss, bleeding, thrombocytopenia, granulocytopenia, bone and joint pain, and enlargement of the lymph nodes, liver, and spleen, and that occurs chiefly during childhood.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003676,,,,,,,,"Lymphocytic leukemia cell that is marked by an abnormal increase in the number of lymphoblasts, that is characterized by rapid onset and progression of symptoms which include fever, anemia, pallor, fatigue, appetite loss, bleeding, thrombocytopenia, granulocytopenia, bone and joint pain, and enlargement of the lymph nodes, liver, and spleen, and that occurs chiefly during childhood.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000731,,,,,,,BrendaTissueOBO,ALL cell|acute lymphocytic leukemia cell,BTO:0000731,,,,,,,,,,,,,,,,,,,acute lymphoblastic leukemia cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100103,"[""Frizzled-1""]",,"A frizzled-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UP38] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300043,,,,,,,,"A frizzled-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UP38] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100103,,,,https://pharos.nih.gov/idg/targets/Q9UP38,,,,,,,,,,,,,FZD1,,,Q9UP38,,,,,,,,Frizzled-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400428,"[""KCNJ1 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400428,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ1 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100048,"[""Serine/threonine-protein kinase brsk1""]",,"serine/threonine-protein kinase brsk1 (BRSK1)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase BRSK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TDC3] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300253,,,,,,,,"serine/threonine-protein kinase brsk1 (BRSK1)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase BRSK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TDC3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100048,,,,https://pharos.nih.gov/idg/targets/Q8TDC3,,,,,,,,,,,,,BRSK1,KIAA1811|SAD1|SADB,,Q8TDC3,,,,,,,,Serine/threonine-protein kinase brsk1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_7541,"[""mixed epithelial/mesenchymal metaplastic breast carcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4680,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:7541,,,,NCI:C40364|UMLS_CUI:C1513365,,,disease_ontology,,DOID:7541,,,,,,,,,,,,,,,,,,,mixed epithelial/mesenchymal metaplastic breast carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100119,"[""Interferon-induced, double-stranded rna-activated protein kinase""]",,"interferon-induced, double-stranded rna-activated protein kinase (PRKR)  with  no mutation  in a nonphosphorylated state|An interferon-induced, double-stranded RNA-activated protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P19525] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300151,,,,,,,,"interferon-induced, double-stranded rna-activated protein kinase (PRKR)  with  no mutation  in a nonphosphorylated state|An interferon-induced, double-stranded RNA-activated protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P19525] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100119,,,,https://pharos.nih.gov/idg/targets/P19525,,,,,,,,,,,,,EIF2AK2,PKR|PRKR,,P19525,,,,,,,,"Interferon-induced, double-stranded rna-activated protein kinase",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0080046,"[""Stickler syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0080046,,,,OMIM:184840|OMIM:108300|OMIM:604841,,,disease_ontology,,DOID:0080046,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Stickler syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0080049,"[""acromesomelic dysplasia""]",,"An osteochondrodysplasia that has_material_basis_in mesomelia and acromelia, which results_in short limb Dwarfism.",false,,,http://purl.obolibrary.org/obo/DOID_2256,,,,,,,,"An osteochondrodysplasia that has_material_basis_in mesomelia and acromelia, which results_in short limb Dwarfism.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0080049,,,,,,,disease_ontology,,DOID:0080049,,,,,,,,,,,,,,,,,,,acromesomelic dysplasia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0080041,"[""hypochondroplasia""]",,An osteochondrodysplasia that has_material_basis_in mutation in the FGFR3 gene which affects ossification of cartilage and results_in short limb dwarfism.,false,,,http://purl.obolibrary.org/obo/DOID_2256,,,,,,,,An osteochondrodysplasia that has_material_basis_in mutation in the FGFR3 gene which affects ossification of cartilage and results_in short limb dwarfism.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0080041,,,,,,,disease_ontology,,DOID:0080041,,,,,,,,,,,,,,,,,,,hypochondroplasia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0080109,"[""infantile myofibromatosis""]",,"A connective tissue benign neoplasm that is characterized by the development of benign tumors in the skin, striated muscles, bones, and in exceptional cases, visceral organs.",false,,,http://purl.obolibrary.org/obo/DOID_0060123,,,,,,,,"A connective tissue benign neoplasm that is characterized by the development of benign tumors in the skin, striated muscles, bones, and in exceptional cases, visceral organs.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0080109,,,,OMIM:228550|OMIM:615293|ORDO:2591,,,,,,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,infantile myofibromatosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0080108,"[""myoglobinuria""]",,A myopathy that is characterized by an increased urinary excretion of myoglobin.,false,,,http://purl.obolibrary.org/obo/DOID_423,,,,,,,,A myopathy that is characterized by an increased urinary excretion of myoglobin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0080108,,,,OMIM:268200|OMIM:160010|OMIM:550500,,,,,DOID:0080108,,,,,,,,,,,,,,,,,,,myoglobinuria,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200524,"[""OR2G2 gene""]",,"An olfactory receptor 2G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200524,,,,,,,,,,,,,,,,81470,OR2G2,,,,,,,,,,,OR2G2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9840,"[""esotropia""]",,Esotropia is a strabismus in which the eye turns inward toward the nose.,false,,,http://purl.obolibrary.org/obo/DOID_540,,,,,,,,Esotropia is a strabismus in which the eye turns inward toward the nose.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9840,,,,MESH:D004948|SNOMEDCT_US_2016_03_01:194085000|SNOMEDCT_US_2016_03_01:194074002|ICD10CM:H50.00|ICD9CM:378.00|SNOMEDCT_US_2016_03_01:155193001|NCI:C34596|SNOMEDCT_US_2016_03_01:16596007|UMLS_CUI:C0014877|ICD9CM:378.0|ICD10CM:H50.0,crossed eyes|Convergence in manifest squint|Internal Strabismus,,disease_ontology,,DOID:9840,,,,,,,,,,,,,,,,,,,esotropia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000783,"[""pancreatic beta cell""]",,One of the cells that compose the bulk of the islets of Langerhans and secrete insulin.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,One of the cells that compose the bulk of the islets of Langerhans and secrete insulin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000783,,,,,,,BrendaTissueOBO,beta cell|pancreatic islet beta cell|islet beta cell|insulin cell|insulin-secreting cell,BTO:0000783,,,,,,,,,,,,,,,,,,,pancreatic beta cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100237,"[""Leucine-rich repeat-containing G-protein coupled receptor 6""]",,"A leucine-rich repeat-containing G-protein coupled receptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HBX8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A leucine-rich repeat-containing G-protein coupled receptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HBX8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100237,,,,https://pharos.nih.gov/idg/targets/Q9HBX8,,,,,,,,,,,,,LGR6,,,Q9HBX8,,,,,,,,Leucine-rich repeat-containing G-protein coupled receptor 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11372,"[""megacolon""]",,A colonic disease that is characterized by an abnormal dilation of the colon.,false,,,http://purl.obolibrary.org/obo/DOID_5353,,,,,,,,A colonic disease that is characterized by an abnormal dilation of the colon.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11372,,,DOID:1771,MESH:D008531|UMLS_CUI:C0025160|SNOMEDCT_US_2016_03_01:33995003|ICD10CM:K59.3|SNOMEDCT_US_2016_03_01:197144003|NCI:C34810|SNOMEDCT_US_2016_03_01:197138002,Dilatation of colon,,disease_ontology,,DOID:11372,,,,,,,,,,,,,,,,,,,megacolon,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11379,"[""gnathomiasis""]",,"A parasitic helminthiasis infectious disease that involves parasitic infection due to migrating immature worms of Gnathostoma spinigerum or Gnathostoma hispidum, which occurs by eating undercooked fish or poultry containing third-stage larvae, or by drinking water containing infective second-stage larvae in Cyclops. Migration in the subcutaneous tissues causes intermittent, migratory, painful, pruritic swellings (cutaneous larva migrans). Migration to other tissues (visceral larva migrans), result in cough, hematuria, and ocular involvement, with the most serious manifestations eosinophilic meningitis with myeloencephalitis.",false,,,http://purl.obolibrary.org/obo/DOID_883,,,,,,,,"A parasitic helminthiasis infectious disease that involves parasitic infection due to migrating immature worms of Gnathostoma spinigerum or Gnathostoma hispidum, which occurs by eating undercooked fish or poultry containing third-stage larvae, or by drinking water containing infective second-stage larvae in Cyclops. Migration in the subcutaneous tissues causes intermittent, migratory, painful, pruritic swellings (cutaneous larva migrans). Migration to other tissues (visceral larva migrans), result in cough, hematuria, and ocular involvement, with the most serious manifestations eosinophilic meningitis with myeloencephalitis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11379,,,,MESH:D058429|SNOMEDCT_US_2016_03_01:44086001|ICD10CM:B83.1|UMLS_CUI:C0018013|ICD9CM:128.1,Infectious Disease by Gnathostoma (disorder)|Gnathostomiasis,,disease_ontology,,DOID:11379,,,,,,,,,,,,,,,,,,,gnathomiasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100766,"[""Sphingosine 1-phosphate receptor 4""]",,"A sphingosine 1-phosphate receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95977] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A sphingosine 1-phosphate receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95977] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100766,,,,https://pharos.nih.gov/idg/targets/O95977,,,,,,,,,,,,,S1PR4,EDG6,,O95977,,,,,,,,Sphingosine 1-phosphate receptor 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200086,"[""CLK1 gene""]",,"This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400140,,,,,,,,"This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200086,,,,,,,,,,,,,,,,1195,CLK1,CLK,,,,,,,,,,CLK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060001,"[""withdrawal disorder""]",,"A substance-related disorder that occurs upon the abrupt discontinuation/separation or a decrease in dosage of the intake of medications, recreational drugs, and alcohol.",false,,,http://purl.obolibrary.org/obo/DOID_303,,,,,,,,"A substance-related disorder that occurs upon the abrupt discontinuation/separation or a decrease in dosage of the intake of medications, recreational drugs, and alcohol.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060001,,,,,,,disease_ontology,,DOID:0060001,,,,,,,,,,,,,,,,,,,withdrawal disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060005,"[""autoimmune disease of endocrine system""]",,A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system resulting in production of antibodies or T cells against cells and/or tissues in the endocrine system.,false,,,http://purl.obolibrary.org/obo/DOID_417|http://purl.obolibrary.org/obo/DOID_28,,,,,,,,A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system resulting in production of antibodies or T cells against cells and/or tissues in the endocrine system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060005,,,,,,,disease_ontology,,DOID:0060005,,,,,,,,,,,,,,,,,,,autoimmune disease of endocrine system,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200060,"[""CDK14 gene""]",,"PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400256,,,,,,,,"PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200060,,,,,,,,,,,,,,,,5218,CDK14,KIAA0834|PFTK1,,,,,,,,,,CDK14 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217545,"[""NR1H2 gene""]",,"The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_00217465,,,,,,,,"The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217545,,,,,,,,,,,,,,,,7376,NR1H2,LXRB|NER|UNR,,,,,,,,,,NR1H2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200077,"[""CXCR3 gene""]",,"A C-X-C chemokine receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49682] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400097,,,,,,,,"A C-X-C chemokine receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49682] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200077,,,,,,,,,,,,,,,,2833,CXCR3,GPR9,,,,,,,,,,CXCR3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100619,"[""Olfactory receptor 5d13""]",,"An olfactory receptor 5D13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5D13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100619,,,,https://pharos.nih.gov/idg/targets/Q8NGL4,,,,,,,,,,,,,OR5D13,,,Q8NGL4,,,,,,,,Olfactory receptor 5d13,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300043,"[""Frizzled receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300005,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300043,,,,,,,,,,,,,,,,,,,,,,,,,,,,Frizzled receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00200002,"[""Nuclear hormone receptor gene""]",,"Nuclear hormone receptor proteins form a class of ligand activated proteins that, when bound to specific sequences of DNA serve as on-off switches for transcription within the cell nucleus. These switches control the development and differentiation of skin, bone and behavioral centers in the brain, as well as the continual regulation of reproductive tissues.",false,,,http://www.drugtargetontology.org/dto/DTO_00200000,,,,,,,,"Nuclear hormone receptor proteins form a class of ligand activated proteins that, when bound to specific sequences of DNA serve as on-off switches for transcription within the cell nucleus. These switches control the development and differentiation of skin, bone and behavioral centers in the brain, as well as the continual regulation of reproductive tissues.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00200002,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.ks.uiuc.edu/Research/pro_DNA/ster_horm_rec/,Nuclear hormone receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3068,"[""glioblastoma multiforme""]",,"An astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derives_from multiple cell types including astrocytes and oligondroctyes.",false,,,http://purl.obolibrary.org/obo/DOID_3069,,,,,,,,"An astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derives_from multiple cell types including astrocytes and oligondroctyes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3068,,,DOID:3080|DOID:3075,SNOMEDCT_US_2016_03_01:63634009|SNOMEDCT_US_2016_03_01:189917003|NCI:C39750|NCI:C3058|UMLS_CUI:C1514422|UMLS_CUI:C0017636|UMLS_CUI:C0278878|NCI:C9094|SNOMEDCT_US_2016_03_01:269506004|MESH:D005909,GBM (Glioblastoma)|grade IV adult Astrocytic tumor|GBM|spongioblastoma multiforme|primary glioblastoma multiforme|adult glioblastoma multiforme,,disease_ontology,,DOID:3068,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,glioblastoma multiforme,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400098,"[""Endothelin type A gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400038,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400098,,,,,,,,,,,,,,,,,,,,,,,,,,,,Endothelin type A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000614,"[""hypothalamus""]",,"The ventral part of the diencephalon that forms the floor and part of the lateral wall of the third ventricle. Anatomically, it includes the preoptic area, optic tract, optic chiasm, mammillary bodies, tuber cinereum, infundibulum, and neurohypophysis, but for physiological purposes the neurohypophysis is considered a distinct structure. The hypothalamus may be divided into five regions or areas (area hypothalamica rostralis, area hypothalamica dorsalis, area hypothalamica intermedia, area hypothalamica lateralis and area hypothalamica posterior) or into three longitudinal zones (periventricular zone, medial zone, and lateral zone). The hypothalamic nuclei constitute that part of the corticodiencephalic mechanism that activates, controls and integrates the peripheral autonomic mechanisms, endocrine activity, and many somatic functions, e.g., a general regulation of water balance, body temperature, sleep, and food intake, and the development of secondary sex characteristics. The hypothalamus secretes vasopressin and oxytocin, which are stored in the pituitary, as well as many releasing factors (hypophysiotropic hormones), by means of which it exerts control over functions of the adenohypophysis.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001488,,,,,,,,"The ventral part of the diencephalon that forms the floor and part of the lateral wall of the third ventricle. Anatomically, it includes the preoptic area, optic tract, optic chiasm, mammillary bodies, tuber cinereum, infundibulum, and neurohypophysis, but for physiological purposes the neurohypophysis is considered a distinct structure. The hypothalamus may be divided into five regions or areas (area hypothalamica rostralis, area hypothalamica dorsalis, area hypothalamica intermedia, area hypothalamica lateralis and area hypothalamica posterior) or into three longitudinal zones (periventricular zone, medial zone, and lateral zone). The hypothalamic nuclei constitute that part of the corticodiencephalic mechanism that activates, controls and integrates the peripheral autonomic mechanisms, endocrine activity, and many somatic functions, e.g., a general regulation of water balance, body temperature, sleep, and food intake, and the development of secondary sex characteristics. The hypothalamus secretes vasopressin and oxytocin, which are stored in the pituitary, as well as many releasing factors (hypophysiotropic hormones), by means of which it exerts control over functions of the adenohypophysis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000614,,,,,,,BrendaTissueOBO,,BTO:0000614,,,,,,,,,,,,,,,,,,,hypothalamus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003666,"[""outer hair cell""]",,"Any of approximately 25,000 hair cells in the organ of Corti, specialized as transducers of sound waves into nerve impulses and sensitive to low sound levels, easily damaged by loud noise (over 85 decibels), and probably involved in encoding information about the loudness of sounds. So called because they are nearer to the outside of the cochlea than are the inner hair cells.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Any of approximately 25,000 hair cells in the organ of Corti, specialized as transducers of sound waves into nerve impulses and sensitive to low sound levels, easily damaged by loud noise (over 85 decibels), and probably involved in encoding information about the loudness of sounds. So called because they are nearer to the outside of the cochlea than are the inner hair cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003666,,,,,,,BrendaTissueOBO,,BTO:0003666,,,,,,,,,,,,,,,,,,,outer hair cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100307,"[""Microtubule-associated serine/threonine-protein kinase 2""]",,"A microtubule-associated serine/threonine-protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6P0Q8] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300160,,,,,,,,"A microtubule-associated serine/threonine-protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6P0Q8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100307,,,,https://pharos.nih.gov/idg/targets/Q6P0Q8,,,,,,,,,,,,,MAST2,KIAA0807|MAST205,,Q6P0Q8,,,,,,,,Microtubule-associated serine/threonine-protein kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4914,"[""esophagus adenocarcinoma""]",,An esophageal carcinoma that derives_from epithelial cells of glandular origin.,false,,,http://purl.obolibrary.org/obo/DOID_1107|http://purl.obolibrary.org/obo/DOID_299,,,,,,,,An esophageal carcinoma that derives_from epithelial cells of glandular origin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4914,,,,SNOMEDCT_US_2016_03_01:276803003|UMLS_CUI:C0279628|MESH:C562730|NCI:C4025,Oesophageal adenocarcinoma NOS|adenocarcinoma of esophagus (disorder),,disease_ontology,adenocarcinoma of esophagus,DOID:4914,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,esophagus adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005500,"[""QGP-1 cell""]",,Human pancreatic neuroendocrine tumor cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000794,,,,,,,,Human pancreatic neuroendocrine tumor cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005500,XPMUser,2013-09-12T12:17:54Z,,,,,BrendaTissueOBO,QGP1 cell,BTO:0005500,,,,,,,,,,,,,,,,,,,QGP-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100105,"[""Epithelial discoidin domain-containing receptor 1""]",,"epithelial discoidin domain-containing receptor 1 (DDR1)  with  no mutation  in a nonphosphorylated state|A discoidin domain-containing receptor 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q08345] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300148,,,,,,,,"epithelial discoidin domain-containing receptor 1 (DDR1)  with  no mutation  in a nonphosphorylated state|A discoidin domain-containing receptor 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q08345] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100105,,,,https://pharos.nih.gov/idg/targets/Q08345,,,,,,,,,,,,,DDR1,CAK|EDDR1|NEP|NTRK4|PTK3A|RTK6|TRKE,,Q08345,,,,,,,,Epithelial discoidin domain-containing receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200390,"[""OR51B6 gene""]",,"An olfactory receptor 51B6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H340] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 51B6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H340] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200390,,,,,,,,,,,,,,,,390058,OR51B6,,,,,,,,,,,OR51B6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5295,"[""intestinal disease""]",,A gastrointestinal system disease that is located_in the intestine.,false,,,http://purl.obolibrary.org/obo/DOID_77,,,,,,,,A gastrointestinal system disease that is located_in the intestine.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5295,,,DOID:8558|DOID:8531|DOID:10759|DOID:8591|DOID:11789|DOID:11222,SNOMEDCT_US_2016_03_01:155629009|SNOMEDCT_US_2016_03_01:266483008|MESH:D007410|SNOMEDCT_US_2016_03_01:197266001|ICD10CM:K63.9|NCI:C26801|SNOMEDCT_US_2016_03_01:85919009|ICD9CM:569.9|UMLS_CUI:C0021831,,,disease_ontology,,DOID:5295,,,,,,,,,,,,,,,,,,,intestinal disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100779,"[""Taste receptor type 2 member 16""]",,"A taste receptor type 2 member 16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYV7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300014,,,,,,,,"A taste receptor type 2 member 16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYV7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100779,,,,https://pharos.nih.gov/idg/targets/Q9NYV7,,,,,,,,,,,,,TAS2R16,,,Q9NYV7,,,,,,,,Taste receptor type 2 member 16,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200286,"[""MAP3K4 gene""]",,"The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, May 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400186,,,,,,,,"The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, May 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200286,,,,,,,,,,,,,,,,4216,MAP3K4,KIAA0213|MAPKKK4|MEKK4,,,,,,,,,,MAP3K4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400112,"[""CK1 group gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400102,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400112,,,,,,,,,,,,,,,,,,,,,,,,,,,,CK1 group gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000148,"[""ERBB4 kinase domain""]",,Receptor tyrosine-protein kinase erbB-4; HER4; MGC138404; p180erbB4,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Receptor tyrosine-protein kinase erbB-4; HER4; MGC138404; p180erbB4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000148,,,,,,,,,,,,,,,,,,,200150,,,,,,,,,ERBB4 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000996,"[""gametocyte""]",,"A cell from which gametes develop by meiotic division, especially a spermatocyte or an oocyte.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A cell from which gametes develop by meiotic division, especially a spermatocyte or an oocyte.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000996,,,,,,,BrendaTissueOBO,,BTO:0000996,,,,,,,,,,,,,,,,,,,gametocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100530,"[""Olfactory receptor 2J1""]",,"An olfactory receptor 2J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZK6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZK6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100530,,,,https://pharos.nih.gov/idg/targets/Q9GZK6,,,,,,,,,,,,,OR2J1,OR2J1P,,Q9GZK6,,,,,,,,Olfactory receptor 2J1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100244,"[""Latrophilin-1""]",,"A latrophilin-1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O94910] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300039,,,,,,,,"A latrophilin-1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O94910] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100244,,,,https://pharos.nih.gov/idg/targets/O94910,,,,,,,,,,,,,LPHN1,ADGRL1|KIAA0821|LEC2,,O94910,,,,,,,,Latrophilin-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200400,"[""OR51I2 gene""]",,"An olfactory receptor 51I2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H344] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 51I2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H344] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200400,,,,,,,,,,,,,,,,390064,OR51I2,,,,,,,,,,,OR51I2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100098,"[""Protein FAM26D""]",,"A protein FAM26D that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5JW98] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300335,,,,,,,,"A protein FAM26D that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5JW98] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100098,,,,https://pharos.nih.gov/idg/targets/Q5JW98,,,,,,,,,,,,,FAM26D,C6orf78,,Q5JW98,,,,,,,,Protein FAM26D,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003215,"[""VCaP cell""]",,Human prostate cancer cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001033,,,,,,,,Human prostate cancer cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003215,,,,,,,BrendaTissueOBO,,BTO:0003215,,,,,,,,,,,,,,,,,,,VCaP cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400455,"[""NR2A/GRIN2A subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400455,,,,,,,,,,,,,,,,,,,,,,,,,,,,NR2A/GRIN2A subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13117,"[""paronychia""]",,"A nail disease characterized by often-tender bacterial or fungal hand infection or foot infection due to either bacteria or fungus (Candida albicans) where the nail and skin meet at the side or the base of a finger or toe nail. The infection can start suddenly (acute paronychia) or gradually (chronic paronychia). Puss is usually present, along with gradual thickening and browning discoloration of the nail plate.",false,,,http://purl.obolibrary.org/obo/DOID_4123,,,,,,,,"A nail disease characterized by often-tender bacterial or fungal hand infection or foot infection due to either bacteria or fungus (Candida albicans) where the nail and skin meet at the side or the base of a finger or toe nail. The infection can start suddenly (acute paronychia) or gradually (chronic paronychia). Puss is usually present, along with gradual thickening and browning discoloration of the nail plate.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13117,,,DOID:11398|DOID:9689,UMLS_CUI:C0030578|ICD10CM:L03.0|SNOMEDCT_US_2016_03_01:267830000|SNOMEDCT_US_2016_03_01:71906005|SNOMEDCT_US_2016_03_01:200643006|NCI:C79702|SNOMEDCT_US_2016_03_01:156305000|MESH:D010304,Onychia and paronychia of toe|fungal nail infection|Onychia and paronychia of finger|Infected nailfold,,disease_ontology,paronychia inflammation,DOID:13117,,,,,,,,,,,,,,,,,,,paronychia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13113,"[""cicatricial entropion""]",,,false,,,http://purl.obolibrary.org/obo/DOID_12397,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13113,,,,ICD9CM:374.04|UMLS_CUI:C0155191|SNOMEDCT_US_2016_03_01:67383002,,,disease_ontology,,DOID:13113,,,,,,,,,,,,,,,,,,,cicatricial entropion,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300210,"[""PKN family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300210,,,,,,,,,,,,,,,,,,,,,,,,,,,,PKN family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001444,"[""Vero cell""]",,"The Vero cell line was initiated from the kidney of a normal adult African green monkey on March 27, 1962, by Y. Yasumura and Y. Kawakita at the Chiba University in Chiba, Japan.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000067,,,,,,,,"The Vero cell line was initiated from the kidney of a normal adult African green monkey on March 27, 1962, by Y. Yasumura and Y. Kawakita at the Chiba University in Chiba, Japan.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001444,,,,,,,BrendaTissueOBO,,BTO:0001444,,,,,,,,,,,,,,,,,,,Vero cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100410,"[""Phosphatidylinositol 5-phosphate 4-kinase type-2 beta""]",,"A phosphatidylinositol 5-phosphate 4-kinase type-2 beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P78356] |phosphatidylinositol 5-phosphate 4-kinase type-2 beta (PIP5K2B)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300323,,,,,,,,"A phosphatidylinositol 5-phosphate 4-kinase type-2 beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P78356] |phosphatidylinositol 5-phosphate 4-kinase type-2 beta (PIP5K2B)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100410,,,,https://pharos.nih.gov/idg/targets/P78356,,,,,,,,,,,,,PIP4K2B,PIP5K2B,,P78356,,,,,,,,Phosphatidylinositol 5-phosphate 4-kinase type-2 beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100400,"[""Putative 3-phosphoinositide-dependent protein kinase 2""]",,A 3-phosphoinositide-dependent protein kinase 2 that is encoded in the genome of human. ,false,,,http://www.drugtargetontology.org/dto/DTO_03300102,,,,,,,,A 3-phosphoinositide-dependent protein kinase 2 that is encoded in the genome of human. ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100400,,,,https://pharos.nih.gov/idg/targets/Q6A1A2,,,,,,,,,,,,,PDPK2P,PDPK2,,Q6A1A2,,,,,,,,Putative 3-phosphoinositide-dependent protein kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200101,"[""FXYD3 gene""]",,"This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400348,,,,,,,,"This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200101,,,,,,,,,,,,,,,,5349,FXYD3,MAT8|PLML,,,,,,,,,,FXYD3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300168,"[""TRIO family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300168,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRIO family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100255,"[""Melanin-concentrating hormone receptor 1""]",,"A melanin-concentrating hormone receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99705] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300052,,,,,,,,"A melanin-concentrating hormone receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99705] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100255,,,,https://pharos.nih.gov/idg/targets/Q99705,,,,,,,,,,,,,MCHR1,GPR24|SLC1,,Q99705,,,,,,,,Melanin-concentrating hormone receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000190,"[""MET627 in KPCD2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000190,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET627 in KPCD2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000971,"[""SAOS-2 cell""]",,"Human osteogenic sarcoma, established from the primary osteogenic sarcoma of an 11-year-old Caucasian woman in 1973.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000407,,,,,,,,"Human osteogenic sarcoma, established from the primary osteogenic sarcoma of an 11-year-old Caucasian woman in 1973.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000971,,,,,,,BrendaTissueOBO,SAOS2 cell,BTO:0000971,,,,,,,,,,,,,,,,,,,SAOS-2 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200491,"[""OR1I1 gene""]",,"An olfactory receptor 1I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60431] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60431] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200491,,,,,,,,,,,,,,,,126370,OR1I1,,,,,,,,,,,OR1I1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100439,"[""Olfactory receptor 56A3""]",,"An olfactory receptor 56A3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH54] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 56A3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH54] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100439,,,,https://pharos.nih.gov/idg/targets/Q8NH54,,,,,,,,,,,,,OR56A3,OR56A3P|OR56A6,,Q8NH54,,,,,,,,Olfactory receptor 56A3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100403,"[""Platelet-derived growth factor receptor alpha""]",,"platelet-derived growth factor receptor alpha (PGFRA)  with  no mutation  in a nonphosphorylated state|An alpha-type platelet-derived growth factor receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P16234] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300141,,,,,,,,"platelet-derived growth factor receptor alpha (PGFRA)  with  no mutation  in a nonphosphorylated state|An alpha-type platelet-derived growth factor receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P16234] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100403,,,,https://pharos.nih.gov/idg/targets/P16234,,,,,,,,,,,,,PDGFRA,PDGFR2|RHEPDGFRA,,P16234,,,,,,,,Platelet-derived growth factor receptor alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_16015,"[""L-glutamic acid""]","a-Aminoglutaric acid|L-Glutaminic acid|Glt|1-Aminopropane-1,3-dicarboxylate|Aciglut|L-alpha-Aminoglutarate|Glusate|2-Aminoglutarate|L-(+)-Glutamic acid|acide glutamique|acido glutamico|Glutaminate|L-a-Aminoglutaric acid|alpha-Glutamic acid|L-Glu|(S)-Glutamate|alpha-Glutamate|Glutacid|1-Amino-propane-1,3-dicarboxylate|(2S)-2-Aminopentanedioic acid|L-Glutaminate|a-Glutamic acid|L-alpha-Aminoglutaric acid|glutamic acid|2-Aminopentanedioic acid|Glutaton|1-Aminopropane-1,3-dicarboxylic acid|alpha-Aminoglutarate|L-(+)-Glutamate|N[C@@H](CCC(O)=O)C(O)=O|2-Aminoglutaric acid|2-Aminopentanedioate|Glutamate|Aminoglutarate|C5H9NO4|E|(S)-glutamic acid|a-Aminoglutarate|Glutaminol|L-Glutaminsaeure|1-Amino-propane-1,3-dicarboxylic acid|Glutamicol|Glutamidex|(2S)-2-Aminopentanedioate|(S)-(+)-Glutamate|WHUUTDBJXJRKMK-VKHMYHEASA-N|(S)-(+)-Glutamic acid|a-Glutamate|L-a-Aminoglutarate|GLUTAMIC ACID|Glu|
InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
|Aminoglutaric acid|acidum glutamicum|Glutaminic acid|(S)-2-aminopentanedioic acid|alpha-Aminoglutaric acid|L-Glutamate|Glut|(S)-2-Aminopentanedioate","
An optically active form of glutamic acid having L-configuration.
",false,,,http://purl.obolibrary.org/obo/CHEBI_33709,,,,,,,NIST Chemistry WebBook:56-86-0|KNApSAcK:C00001358|CiteXplore:22219301|CiteXplore:12097436|CiteXplore:15911239|CiteXplore:19212411|CiteXplore:12073073|Reaxys:1723801|CiteXplore:15596234|CiteXplore:15592994|Beilstein:1723801|CiteXplore:10736365|Wikipedia:L-Glutamic_Acid|DrugBank:DB00142|KEGG DRUG:D00007|Gmelin:3502|CiteXplore:9465528|ChemIDplus:56-86-0|CiteXplore:3162516|CiteXplore:18502700|CiteXplore:20300169|CiteXplore:6696735|KEGG COMPOUND:C00025|CiteXplore:16892196|MetaCyc:GLT|CiteXplore:7901400|CiteXplore:12869660|CiteXplore:14749132|CiteXplore:15930465|CiteXplore:10736373|CiteXplore:2453224|CiteXplore:1851687|CiteXplore:8579834|CiteXplore:15939876|CiteXplore:12297216|CiteXplore:10052870|CiteXplore:16400059|CiteXplore:11304775|Wikipedia:E|CiteXplore:9004939|CiteXplore:15135231|CiteXplore:19581495|CiteXplore:22735334|HMDB:HMDB00148|CiteXplore:17202478|CiteXplore:22411374|CiteXplore:16719819|PDBeChem:GLU_LFOH|CiteXplore:15739367|KEGG COMPOUND:56-86-0|CiteXplore:14992292,"
An optically active form of glutamic acid having L-configuration.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:42825|CHEBI:6224|CHEBI:21304,,(2S)-2-aminopentanedioic acid|L-glutamic acid|L-Glutamic acid,,chebi_ontology,"a-Aminoglutaric acid|L-Glutaminic acid|Glt|1-Aminopropane-1,3-dicarboxylate|Aciglut|L-alpha-Aminoglutarate|Glusate|2-Aminoglutarate|L-(+)-Glutamic acid|acide glutamique|acido glutamico|Glutaminate|L-a-Aminoglutaric acid|alpha-Glutamic acid|L-Glu|(S)-Glutamate|alpha-Glutamate|Glutacid|1-Amino-propane-1,3-dicarboxylate|(2S)-2-Aminopentanedioic acid|L-Glutaminate|a-Glutamic acid|L-alpha-Aminoglutaric acid|glutamic acid|2-Aminopentanedioic acid|Glutaton|1-Aminopropane-1,3-dicarboxylic acid|alpha-Aminoglutarate|L-(+)-Glutamate|N[C@@H](CCC(O)=O)C(O)=O|2-Aminoglutaric acid|2-Aminopentanedioate|Glutamate|Aminoglutarate|C5H9NO4|E|(S)-glutamic acid|a-Aminoglutarate|Glutaminol|L-Glutaminsaeure|1-Amino-propane-1,3-dicarboxylic acid|Glutamicol|Glutamidex|(2S)-2-Aminopentanedioate|(S)-(+)-Glutamate|WHUUTDBJXJRKMK-VKHMYHEASA-N|(S)-(+)-Glutamic acid|a-Glutamate|L-a-Aminoglutarate|GLUTAMIC ACID|Glu|
InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
|Aminoglutaric acid|acidum glutamicum|Glutaminic acid|(S)-2-aminopentanedioic acid|alpha-Aminoglutaric acid|L-Glutamate|Glut|(S)-2-Aminopentanedioate",,,CHEBI:16015,,,,,,,,,,,,,,,,,,,,,,,CHEBI:16015,,,,,L-glutamic acid,,CHEBI:16015,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100745,"[""Prostaglandin E2 receptor EP3 subtype""]",,"A prostaglandin E2 receptor EP3 subtype that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43115] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A prostaglandin E2 receptor EP3 subtype that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43115] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100745,,,,https://pharos.nih.gov/idg/targets/P43115,,,,,,,,,,,,,PTGER3,,,P43115,,,,,,,,Prostaglandin E2 receptor EP3 subtype,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003605,"[""1321-N1 cell""]",,Human astrocytoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000101,,,,,,,,Human astrocytoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003605,,,,,,,BrendaTissueOBO,1321N1 cell|1321 N1 cell,BTO:0003605,,,,,,,,,,,,,,,,,,,1321-N1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004352,"[""pulvinar""]",,"Large mass of nuclei forming the most caudal portion of the thalamus and overhanging the geniculate bodies and the dorsolateral surface of the midbrain. It is divided into four parts: the lateral, medial, inferior, and oral pulvinar nuclei.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Large mass of nuclei forming the most caudal portion of the thalamus and overhanging the geniculate bodies and the dorsolateral surface of the midbrain. It is divided into four parts: the lateral, medial, inferior, and oral pulvinar nuclei.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004352,,,,,,,BrendaTissueOBO,,BTO:0004352,,,,,,,,,,,,,,,,,,,pulvinar,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_58961,"[""N-arachidonoylglycine""]","N-Arachidonyl-L-glycine|NAGly|N-arachidonoyl glycine|C22H35NO3|
2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenamido]acetic acid
|N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycine|YLEARPUNMCCKMP-DOFZRALJSA-N|
InChI=1S/C22H35NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21(24)23-20-22(25)26/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-20H2,1H3,(H,23,24)(H,25,26)/b7-6-,10-9-,13-12-,16-15-
|CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCC(O)=O|N-Arachidonylglycine",Biologically active derivative of anandamide,false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,Beilstein:7652004|HMDB:HMDB05096|SUBMITTER:LMFA08020003|CiteXplore:21359215,Biologically active derivative of anandamide,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,"N-Arachidonoylglycine|
N-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]glycine
",,chebi_ontology,"N-Arachidonyl-L-glycine|NAGly|N-arachidonoyl glycine|C22H35NO3|
2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenamido]acetic acid
|N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycine|YLEARPUNMCCKMP-DOFZRALJSA-N|
InChI=1S/C22H35NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21(24)23-20-22(25)26/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-20H2,1H3,(H,23,24)(H,25,26)/b7-6-,10-9-,13-12-,16-15-
|CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCC(O)=O|N-Arachidonylglycine",,,CHEBI:58961,,,,,,,,,,,,,,,,,,,,,,,CHEBI:58961,,,,,N-arachidonoylglycine,,CHEBI:58961,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400158,"[""FGFR family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400158,,,,,,,,,,,,,,,,,,,,,,,,,,,,FGFR family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000021,"[""CXCL1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000021,,,,,,,,,,,,,,,,,,,,,,,,,,,,CXCL1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200469,"[""SGK223 gene""]",,"This gene encodes an enzyme that belongs to the tyrosine protein kinase family. A similar protein in rat binds to Rho family GTPase 2 (Rnd2) and regulates neurite outgrowth via activation of Ras homolog gene family, member A (RhoA). [provided by RefSeq, Mar 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400204,,,,,,,,"This gene encodes an enzyme that belongs to the tyrosine protein kinase family. A similar protein in rat binds to Rho family GTPase 2 (Rnd2) and regulates neurite outgrowth via activation of Ras homolog gene family, member A (RhoA). [provided by RefSeq, Mar 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200469,,,,,,,,,,,,,,,,157285,SGK223,,,,,,,,,,,SGK223 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300160,"[""MAST family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300160,,,,,,,,,,,,,,,,,,,,,,,,,,,,MAST family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001434,"[""vegetative cell""]",,"1: Growing or having the power of growing. 2: Of, relating to, or engaged in nutritive and growth functions as contrasted with reproductive functions.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002322,,,,,,,,"1: Growing or having the power of growing. 2: Of, relating to, or engaged in nutritive and growth functions as contrasted with reproductive functions.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001434,,,,,,,BrendaTissueOBO,vegetative,BTO:0001434,,,,,,,,,,,,,,,,,,,vegetative cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000048,"[""Hemokinin 1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000048,,,,,,,,,,,,,,,,,,,,,,,,,,,,Hemokinin 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_963,"[""episodic ataxia""]",,A hereditary ataxia characterized by sporadic bouts of ataxia with or without continuous muscle movement.,false,,,http://purl.obolibrary.org/obo/DOID_0050951,,,,,,,,A hereditary ataxia characterized by sporadic bouts of ataxia with or without continuous muscle movement.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:963,,,,UMLS_CUI:C1720189|SNOMEDCT_US_2016_03_01:421455009|ORDO:211062|MESH:C580065,Isaacs syndrome,,disease_ontology,,DOID:963,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].
Updated outdated UMLS CUI.",,episodic ataxia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_96,"[""staphyloenterotoxemia""]",,"A primary bacterial infectious disease that results_in infection located_in intestine caused by eating food contaminated with enterotoxins produced by bacteria, has_material_basis_in Staphylococcus aureus. The infection has_symptom diarrhea, has_symptom vomiting, has_symptom nausea, has_symptom cramps, and has_symptom weakness.",false,,,http://purl.obolibrary.org/obo/DOID_0050338,,,,,,,,"A primary bacterial infectious disease that results_in infection located_in intestine caused by eating food contaminated with enterotoxins produced by bacteria, has_material_basis_in Staphylococcus aureus. The infection has_symptom diarrhea, has_symptom vomiting, has_symptom nausea, has_symptom cramps, and has_symptom weakness.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:96,,,,MESH:D013202|SNOMEDCT_US_2016_03_01:84622004|ICD9CM:005.0|UMLS_CUI:C0038159|ICD10CM:A05.0|NCI:C35037,Staphylococcal toxaemia due to food|Staphylococcal food poisoning|staphyloenterotoxicosis,,disease_ontology,,DOID:96,http://purl.obolibrary.org/obo/doid#gram-positive_bacterial_infectious_disease|http://purl.obolibrary.org/obo/doid#GOLD,,,,,,,,,,,,,,,,,,staphyloenterotoxemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_962,"[""neurofibroma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3193,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:962,,,,SNOMEDCT_US_2016_03_01:189947001|NCI:C3272|SNOMEDCT_US_2016_03_01:115242003|SNOMEDCT_US_2016_03_01:134214003|SNOMEDCT_US_2016_03_01:89084002|UMLS_CUI:C0027830|SNOMEDCT_US_2016_03_01:404029005|MESH:D009455,,,disease_ontology,,DOID:962,,,,,,,,,,,,,,,,,,,neurofibroma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004229,"[""testicular cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004229,,,,,,,BrendaTissueOBO,,BTO:0004229,,,,,,,,,,,,,,,,,,,testicular cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4970,"[""prosopagnosia""]",,An agnosia that results in the loss of the ability to consciously recognize familiar faces.,false,,,http://purl.obolibrary.org/obo/DOID_4090,,,,,,,,An agnosia that results in the loss of the ability to consciously recognize familiar faces.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4970,,,,SNOMEDCT_US_2016_03_01:18358003|ICD10CM:R48.3|MESH:D020238|NCI:C85031|UMLS_CUI:C0234512,,,disease_ontology,,DOID:4970,,,,,,,,,,,,,,,,,,,prosopagnosia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000047,"[""AXL kinase domain""]",,AXL receptor tyrosine kinase; AXL; JTK11; UFO,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,AXL receptor tyrosine kinase; AXL; JTK11; UFO,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000047,,,,,,,,,,,,,,,,,,,200047,,,,,,,,,AXL kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200082,"[""CLIC4 gene""]",,"Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400342,,,,,,,,"Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200082,,,,,,,,,,,,,,,,25932,CLIC4,,,,,,,,,,,CLIC4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003761,"[""SNB-19 cell""]",,Human glioblastoma cell line; established from the surgical resection of a left parieto-occipital glioblastoma from a 47-year-old man in 1980.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001530,,,,,,,,Human glioblastoma cell line; established from the surgical resection of a left parieto-occipital glioblastoma from a 47-year-old man in 1980.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003761,,,,,,,BrendaTissueOBO,SNB19 cell,BTO:0003761,,,,,,,,,,,,,,,,,,,SNB-19 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100062,"[""Cyclin-dependent kinase 16""]",,"A cyclin-dependent kinase 16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q00536] |cyclin-dependent kinase 16 (CDK16)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300256,,,,,,,,"A cyclin-dependent kinase 16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q00536] |cyclin-dependent kinase 16 (CDK16)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100062,,,,https://pharos.nih.gov/idg/targets/Q00536,,,,,,,,,,,,,CDK16,PCTAIRE1|PCTK1,,Q00536,,,,,,,,Cyclin-dependent kinase 16,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1272,"[""telangiectasis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_341,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1272,,,,UMLS_CUI:C0039446|SNOMEDCT_US_2016_03_01:266324004|NCI:C28194|MESH:D013684|SNOMEDCT_US_2016_03_01:155449008|SNOMEDCT_US_2016_03_01:112641009|SNOMEDCT_US_2016_03_01:247479008|SNOMEDCT_US_2016_03_01:276328002,telangiectasia,,disease_ontology,,DOID:1272,,,,,,,,,,,,,,,,,,,telangiectasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000019,"[""A7r5 cell""]",,Rat embryonic thoracic aorta smooth muscle cell line. The cells exhibit an increase in activity of the enzymes myokinase and creatine phosphokinase (CPK) as the culture reaches stationary phase. Muscle type CPK is synthesized after cell division has ceased.,false,,,http://purl.obolibrary.org/obo/BTO_0001200|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000669,,,,,,,,Rat embryonic thoracic aorta smooth muscle cell line. The cells exhibit an increase in activity of the enzymes myokinase and creatine phosphokinase (CPK) as the culture reaches stationary phase. Muscle type CPK is synthesized after cell division has ceased.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000019,,,,,,,BrendaTissueOBO,,BTO:0000019,,,,,,,,,,,,,,,,,,,A7r5 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2170,"[""vaginitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_121,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2170,,,DOID:10769,SNOMEDCT_US_2016_03_01:198212006|SNOMEDCT_US_2016_03_01:266655004|SNOMEDCT_US_2016_03_01:198223005|SNOMEDCT_US_2016_03_01:155981006|UMLS_CUI:C0042267|MESH:D014627|ICD9CM:616.1|UMLS_CUI:C0042268|SNOMEDCT_US_2016_03_01:30800001|ICD9CM:616.10|SNOMEDCT_US_2016_03_01:393596009|NCI:C26911|SNOMEDCT_US_2016_03_01:198213001,,,disease_ontology,,DOID:2170,,,,,,,,,,,,,,,,,,,vaginitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300340,"[""Intracellular chloride channel (icc) family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300340,,,,,,,,,,,,,,,,,,,,,,,,,,,,Intracellular chloride channel (icc) family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000373,"[""THR670 in KIT(V559D)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000373,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR670 in KIT(V559D),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400188,"[""MAPKAPK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400188,,,,,,,,,,,,,,,,,,,,,,,,,,,,MAPKAPK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001975,"[""placental cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001975,,,,,,,BrendaTissueOBO,,BTO:0001975,,,,,,,,,,,,,,,,,,,placental cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100184,"[""Probable g-protein coupled receptor 21""]",,"A G-protein coupled receptor 21 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99679] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300053,,,,,,,,"A G-protein coupled receptor 21 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99679] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100184,,,,https://pharos.nih.gov/idg/targets/Q99679,,,,,,,,,,,,,GPR21,,,Q99679,,,,,,,,Probable g-protein coupled receptor 21,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5165,"[""uterine corpus sarcoma""]",,An uterine corpus cancer that is located_in the muscles of the uterus or located_in other tissues that support the uterus.,false,,,http://purl.obolibrary.org/obo/DOID_1115|http://purl.obolibrary.org/obo/DOID_9460,,,,,,,,An uterine corpus cancer that is located_in the muscles of the uterus or located_in other tissues that support the uterus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5165,,,,SNOMEDCT_US_2016_03_01:254877001|NCI:C6339|UMLS_CUI:C0338113,sarcoma of Corpus Uteri|sarcoma of uterus (disorder),,disease_ontology,,DOID:5165,,,,,,,,,,,,,,,,,,,uterine corpus sarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100521,"[""Dual specificity testis-specific protein kinase 2""]",,"A dual specificity testis-specific protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96S53] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300182,,,,,,,,"A dual specificity testis-specific protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96S53] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100521,,,,https://pharos.nih.gov/idg/targets/Q96S53,,,,,,,,,,,,,TESK2,,,Q96S53,,,,,,,,Dual specificity testis-specific protein kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000584,"[""pancreatic cancer cell""]",,Pancreatic cancer is a disease in which malignant (cancer) cells are found in the tissues of the pancreas.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000604,,,,,,,,Pancreatic cancer is a disease in which malignant (cancer) cells are found in the tissues of the pancreas.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000584,,,,,,,BrendaTissueOBO,exocrine cancer cell|pancreatic adenocarcinoma cell|pancreatic carcinoma cell,BTO:0000584,,,,,,,,,,,,,,,,,,,pancreatic cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1924,"[""hypogonadism""]",,A gonadal disease that is characterized by diminished functional activity of the gonads.,false,,,http://purl.obolibrary.org/obo/DOID_2277,,,,,,,,A gonadal disease that is characterized by diminished functional activity of the gonads.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1924,,,,SNOMEDCT_US_2016_03_01:48130008|MESH:D007006|UMLS_CUI:C0020619|NCI:C9227|OMIM:241100|OMIM:307300,,,disease_ontology,,DOID:1924,,,,,,,,,,,,,,,,,,,hypogonadism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060013,"[""gamma chain deficiency""]",,"A severe combined immunodeficiency that is a X-linked SCID that has material basis in mutations in genes encoding common gamma chain proteins shared by the interleukin (IL-2,4,7,9,16 and21) receptors resulting in a non-functional gamma chain, defective interleukin signalling, minimal or ascent T- and NK cells and non-functional B-cells.",false,,,http://purl.obolibrary.org/obo/DOID_627,,,,,,,,"A severe combined immunodeficiency that is a X-linked SCID that has material basis in mutations in genes encoding common gamma chain proteins shared by the interleukin (IL-2,4,7,9,16 and21) receptors resulting in a non-functional gamma chain, defective interleukin signalling, minimal or ascent T- and NK cells and non-functional B-cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060013,,,DOID:5811,SNOMEDCT_US_2016_03_01:203592006|SNOMEDCT_US_2016_03_01:234569003|UMLS_CUI:C1279481|NCI:C4682|MESH:D053632|OMIM:300400,XSCID|X-Linked Severe Combined Immunodeficiency|SCID-X1|thymic epithelial hypoplasia,,disease_ontology,,DOID:0060013,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,gamma chain deficiency,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060014,"[""CD45 deficiency""]",,"A severe combined immunodeficiency that is an autosomal recessive disease with T and B lymphocyte dysfunction, due to a large deletion at one allelle and a point mutation at the other. The point mutation resulted in the alteration of intervening sequence 13 donor splice site. The population of T lymphocytes is diminished and unresponsive to mitogen stimulation. The level of B lymphocyte numbers, serum immunoglobulin decreased with age.",false,,,http://purl.obolibrary.org/obo/DOID_627,,,,,,,,"A severe combined immunodeficiency that is an autosomal recessive disease with T and B lymphocyte dysfunction, due to a large deletion at one allelle and a point mutation at the other. The point mutation resulted in the alteration of intervening sequence 13 donor splice site. The population of T lymphocytes is diminished and unresponsive to mitogen stimulation. The level of B lymphocyte numbers, serum immunoglobulin decreased with age.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060014,,,,,,,disease_ontology,,DOID:0060014,,,,,,,,,,,,,,,,,,,CD45 deficiency,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060015,"[""interleukin-7 receptor alpha deficiency""]",,"A severe combined immunodeficiency that results from defective IL7R expression causes T-B+NK+ SCID. Loss of IL-7R function leads to the loss of an antiapoptotic signal, resulting in a loss of T-cell selection in thymus.",false,,,http://purl.obolibrary.org/obo/DOID_627,,,,,,,,"A severe combined immunodeficiency that results from defective IL7R expression causes T-B+NK+ SCID. Loss of IL-7R function leads to the loss of an antiapoptotic signal, resulting in a loss of T-cell selection in thymus.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060015,,,,,IL-7R,,disease_ontology,,DOID:0060015,,,,,,,,,,,,,,,,,,,interleukin-7 receptor alpha deficiency,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000709,"[""secondary spermatocyte""]",,"One of the two cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids; called also prespermatid.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"One of the two cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids; called also prespermatid.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000709,,,,,,,BrendaTissueOBO,prespermatid,BTO:0000709,,,,,,,,,,,,,,,,,,,secondary spermatocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100007,"[""Abelson tyrosine-protein kinase 2""]",,"An Abelson tyrosine-protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42684] |abelson tyrosine-protein kinase 2 (ABL2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300117,,,,,,,,"An Abelson tyrosine-protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42684] |abelson tyrosine-protein kinase 2 (ABL2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100007,,,,https://pharos.nih.gov/idg/targets/P42684,,,,,,,,,,,,,ABL2,ABLL|ARG,,P42684,,,,,,,,Abelson tyrosine-protein kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000181,"[""MET486 in RSK3(Kin.Dom.2-C-terminal)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000181,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET486 in RSK3(Kin.Dom.2-C-terminal),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8411,"[""kidney angiomyolipoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3116|http://purl.obolibrary.org/obo/DOID_3314,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8411,,,,UMLS_CUI:C0241961|SNOMEDCT_US_2016_03_01:254921004|NCI:C3888,Angiomyolipoma of kidney (disorder)|renal Angiomyolipoma,,disease_ontology,,DOID:8411,,,,,,,,,,,,,,,,,,,kidney angiomyolipoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100630,"[""6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300325,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100630,,,,https://pharos.nih.gov/idg/targets/P16118,,,,,,,,,,,,,PFKFB1,,,P16118,,,,,,,,"6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100515,"[""Serine/threonine-protein kinase tao2""]",,"serine/threonine-protein kinase tao2 (TAOK2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase TAO2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UL54] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300318,,,,,,,,"serine/threonine-protein kinase tao2 (TAOK2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase TAO2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UL54] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100515,,,,https://pharos.nih.gov/idg/targets/Q9UL54,,,,,,,,,,,,,TAOK2,KIAA0881|MAP3K17|PSK|PSK1,,Q9UL54,,,,,,,,Serine/threonine-protein kinase tao2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100339,"[""Dual specificity mitogen-activated protein kinase kinase 6""]",,"A dual specificity mitogen-activated protein kinase kinase 6 that is encoded in the genome of human. [TLR:AMM, UniProtKB:P52564] |dual specificity mitogen-activated protein kinase kinase 6 (MP2K6)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300194,,,,,,,,"A dual specificity mitogen-activated protein kinase kinase 6 that is encoded in the genome of human. [TLR:AMM, UniProtKB:P52564] |dual specificity mitogen-activated protein kinase kinase 6 (MP2K6)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100339,,,,https://pharos.nih.gov/idg/targets/P52564,,,,,,,,,,,,,MAP2K6,MEK6|MKK6|PRKMK6|SKK3,,P52564,,,,,,,,Dual specificity mitogen-activated protein kinase kinase 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9637,"[""stomatitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_403,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9637,,,,SNOMEDCT_US_2016_03_01:196527002|SNOMEDCT_US_2016_03_01:155660009|UMLS_CUI:C0038362|MESH:D013280|NCI:C26887|ICD10CM:K12.1|SNOMEDCT_US_2016_03_01:61170000|SNOMEDCT_US_2016_03_01:95361005,,,disease_ontology,,DOID:9637,,,,,,,,,,,,,,,,,,,stomatitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3307,"[""teratoma""]",,A germ cell and embryonal cancer that is an encapsulated tumor with tissue or organ components resembling normal derivatives of all three germ layers.,false,,,http://purl.obolibrary.org/obo/DOID_3095,,,,,,,,A germ cell and embryonal cancer that is an encapsulated tumor with tissue or organ components resembling normal derivatives of all three germ layers.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3307,,,,NCI:C3403|MESH:D013724|SNOMEDCT_US_2016_03_01:189844009|SNOMEDCT_US_2016_03_01:189848007|UMLS_CUI:C0039538|SNOMEDCT_US_2016_03_01:55818009|SNOMEDCT_US_2016_03_01:189846006,Teratomas (morphologic abnormality),,disease_ontology,,DOID:3307,,,,,,,,,,,,,,,,,,,teratoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400221,"[""RYK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400221,,,,,,,,,,,,,,,,,,,,,,,,,,,,RYK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000888,"[""muscle fibre""]",,An elongated contractile cell that forms the muscles of the body.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,An elongated contractile cell that forms the muscles of the body.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000888,,,,,,,BrendaTissueOBO,muscle fiber|muscle cell|myocyte,BTO:0000888,,,,,,,,,,,,,,,,,,,muscle fibre,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200785,"[""TAS2R39 gene""]",,"A taste receptor type 2 member 39 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59534] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400014,,,,,,,,"A taste receptor type 2 member 39 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59534] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200785,,,,,,,,,,,,,,,,259285,TAS2R39,,,,,,,,,,,TAS2R39 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100246,"[""Leucine-rich repeat-containing protein 38""]",,"A leucine-rich repeat-containing protein 38 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5VT99] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,"A leucine-rich repeat-containing protein 38 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5VT99] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100246,,,,https://pharos.nih.gov/idg/targets/Q5VT99,,,,,,,,,,,,,LRRC38,,,Q5VT99,,,,,,,,Leucine-rich repeat-containing protein 38,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_23367,"[""Molecular entity""]",molecular entities|molekulare Entitaet|entite moleculaire|entidades moleculares|.|entidad molecular,"
Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity.
|Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity.",false,,,http://purl.obolibrary.org/obo/CHEBI_24431,,,,,,,,"
Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity.
|Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,molecular entity,,chebi_ontology,molecular entities|molekulare Entitaet|entite moleculaire|entidades moleculares|.|entidad molecular,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:23367,,,,,Molecular entity|molecular entity,,CHEBI:23367,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100686,"[""Olfactory receptor 8b2""]",,"An olfactory receptor 8B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 8B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100686,,,,https://pharos.nih.gov/idg/targets/Q96RD0,,,,,,,,,,,,,OR8B2,,,Q96RD0,,,,,,,,Olfactory receptor 8b2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3368,"[""bone Ewing's sarcoma""]",,A peripheral primitive neuroectodermal tumor that is located_in bone.,false,,,http://purl.obolibrary.org/obo/DOID_3369,,,,,,,,A peripheral primitive neuroectodermal tumor that is located_in bone.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3368,,,DOID:6392|DOID:4984,UMLS_CUI:C1334406|UMLS_CUI:C1333481|SNOMEDCT_US_2016_03_01:307608006|NCI:C6623|NCI:C35871|NCI:C4835|UMLS_CUI:C0585474,Ewing's sarcoma/bone peripheral primitive neuroectodermal tumor|bone localized Ewing's sarcoma|localized Skeletal Ewing's sarcoma|bone Ewing sarcoma|bone localized Ewing sarcoma,,disease_ontology,bone Ewing's sarcoma|Skeletal Ewing's tumor|Ewing's sarcoma of bone,DOID:3368,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,bone Ewing's sarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000288,"[""PHE89 in CDKL5""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000288,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE89 in CDKL5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100262,"[""Mas-related g-protein coupled receptor member x2""]",,"A mas-related G-protein coupled receptor X2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96LB1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300063,,,,,,,,"A mas-related G-protein coupled receptor X2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96LB1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100262,,,,https://pharos.nih.gov/idg/targets/Q96LB1,,,,,,,,,,,,,MRGPRX2,MRGX2,,Q96LB1,,,,,,,,Mas-related g-protein coupled receptor member x2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11527,"[""laryngostenosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_786,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11527,,,,ICD10CM:J38.6|NCI:C79608|MESH:D007829|SNOMEDCT_US_2016_03_01:195864007|UMLS_CUI:C0023075|ICD9CM:478.74|SNOMEDCT_US_2016_03_01:75547007,Stenosis of larynx,,disease_ontology,,DOID:11527,,,,,,,,,,,,,,,,,,,laryngostenosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300255,"[""CRK7 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300136,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300255,,,,,,,,,,,,,,,,,,,,,,,,,,,,CRK7 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100122,"[""Eukaryotic elongation factor 2 kinase""]",,"An elongation factor 2 kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00418] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300270,,,,,,,,"An elongation factor 2 kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00418] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100122,,,,https://pharos.nih.gov/idg/targets/O00418,,,,,,,,,,,,,EEF2K,,,O00418,,,,,,,,Eukaryotic elongation factor 2 kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8602,"[""gum cancer""]",,,false,,,http://purl.obolibrary.org/obo/DOID_8618,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8602,,,DOID:8734,ICD9CM:143.9|ICD9CM:143|ICD10CM:C03|SNOMEDCT_US_2016_03_01:93819009|NCI:C9317|ICD10CM:C03.9|SNOMEDCT_US_2016_03_01:187651005|SNOMEDCT_US_2016_03_01:363382005|UMLS_CUI:C0153364,malignant neoplasm of gum|malignant neoplasm of other sites of gum|malignant Gingival tumor|malignant tumour of gingiva|malignant neoplasm of gum NOS (disorder)|malignant neoplasm of other sites of gum (disorder)|malignant tumor of gum (disorder),,disease_ontology,,DOID:8602,,,,,,,,,,,,,,,,,,,gum cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400506,"[""GABRA1 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400506,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRA1 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400181,"[""NDR family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400181,,,,,,,,,,,,,,,,,,,,,,,,,,,,NDR family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80275,"[""Tuberoinfundibular peptide of 39 residues""]",TIP39,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16053,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,TIP39,,,CHEBI:80275,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80275,,,,,Tuberoinfundibular peptide of 39 residues,,CHEBI:80275,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200466,"[""SBK3 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400222,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200466,,,,,,,,,,,,,,,,100130827,SBK3,SGK110,,,,,,,,,,SBK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9281,"[""phenylketonuria""]",,"An amino acid metabolic disorder that is characterized by a mutation in the gene for the hepatic enzyme phenylalanine hydroxylase (PAH), rendering it nonfunctional.",false,,,http://purl.obolibrary.org/obo/DOID_9252,,,,,,,,"An amino acid metabolic disorder that is characterized by a mutation in the gene for the hepatic enzyme phenylalanine hydroxylase (PAH), rendering it nonfunctional.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9281,,,DOID:14455,SNOMEDCT_US_2016_03_01:297225000|MESH:D010661|UMLS_CUI:C0031485|SNOMEDCT_US_2016_03_01:190687004|ICD9CM:270.1|SNOMEDCT_US_2016_03_01:154735006|UMLS_CUI:C0085547|MESH:D017042|NCI:C81315|OMIM:261600,phenylalaninemia|maternal phenylketonuria|PKU|Følling's disease,,disease_ontology,,DOID:9281,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,phenylketonuria,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100047,"[""C5a anaphylatoxin chemotactic receptor 2""]",,"A C5a anaphylatoxin chemotactic receptor C5L2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9P296] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300027,,,,,,,,"A C5a anaphylatoxin chemotactic receptor C5L2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9P296] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100047,,,,https://pharos.nih.gov/idg/targets/Q9P296,,,,,,,,,,,,,C5AR2,C5L2|GPR77,,Q9P296,,,,,,,,C5a anaphylatoxin chemotactic receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400534,"[""Kv1.3/KCNA3 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400436,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400534,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv1.3/KCNA3 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200614,"[""NME4 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200614,,,,,,,,,,,,,,,,,,,,,,,,,,,,NME4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100199,"[""Atp-dependent 6-phosphofructokinase, liver type""]",,"A 6-phosphofructokinase, liver type that is encoded in the genome of human. [PRO:DNx, UniProtKB:P17858] ",false,,,http://www.drugtargetontology.org/dto/DTO_03390989,,,,,,,,"A 6-phosphofructokinase, liver type that is encoded in the genome of human. [PRO:DNx, UniProtKB:P17858] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100199,,,,https://pharos.nih.gov/idg/targets/P17858,,,,,,,,,,,,,PFKL,,,P17858,,,,,,,,"Atp-dependent 6-phosphofructokinase, liver type",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200283,"[""FXYD1 gene""]",,"This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5' UTR sequences have been described in the literature. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400348,,,,,,,,"This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5' UTR sequences have been described in the literature. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200283,,,,,,,,,,,,,,,,5348,FXYD1,PLM,,,,,,,,,,FXYD1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300425,"[""KCNJ14 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300425,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ14 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9588,"[""encephalitis""]",,A brain disease that is characterized as an acute inflammation of the brain with flu-like symptoms.,false,,,http://purl.obolibrary.org/obo/DOID_936,,,,,,,,A brain disease that is characterized as an acute inflammation of the brain with flu-like symptoms.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9588,,,DOID:2160,SNOMEDCT_US_2016_03_01:45170000|NCI:C26760|UMLS_CUI:C0014038|MESH:D004660|SNOMEDCT_US_2016_03_01:192736002|SNOMEDCT_US_2016_03_01:267682000|SNOMEDCT_US_2016_03_01:267578009,,,disease_ontology,,DOID:9588,,,,,,,,,,,,,,,,,,,encephalitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3963,"[""thyroid carcinoma""]",,A thyroid cancer that has_material_basis_in epithelial cells.,false,,,http://purl.obolibrary.org/obo/DOID_305|http://purl.obolibrary.org/obo/DOID_1781,,,,,,,,A thyroid cancer that has_material_basis_in epithelial cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3963,,,,UMLS_CUI:C0549473|NCI:C4815|EFO:0002892|MESH:D013964,"head and neck cancer, Thyroid",,disease_ontology,,DOID:3963,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,thyroid carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001958,"[""embryonic fibroblast cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000453|http://purl.obolibrary.org/obo/BTO_0000669,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001958,,,,,,,BrendaTissueOBO,,BTO:0001958,,,,,,,,,,,,,,,,,,,embryonic fibroblast cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200180,"[""IGF1R gene""]",,"This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400163,,,,,,,,"This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200180,,,,,,,,,,,,,,,,3480,IGF1R,,,,,,,,,,,IGF1R gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200513,"[""TAF1 gene""]",,"Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N- and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Mutations in this gene result in Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing of this gene results in multiple transcript variants. This gene is part of a complex transcription unit (TAF1/DYT3), wherein some transcript variants share exons with TAF1 as well as additional downstream DYT3 exons. [provided by RefSeq, Oct 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400231,,,,,,,,"Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N- and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Mutations in this gene result in Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing of this gene results in multiple transcript variants. This gene is part of a complex transcription unit (TAF1/DYT3), wherein some transcript variants share exons with TAF1 as well as additional downstream DYT3 exons. [provided by RefSeq, Oct 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200513,,,,,,,,,,,,,,,,6872,TAF1,BA2R|CCG1|CCGS,,,,,,,,,,TAF1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300287,"[""KHS subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300187,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300287,,,,,,,,,,,,,,,,,,,,,,,,,,,,KHS subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3454,"[""brain infarction""]",,,false,,,http://purl.obolibrary.org/obo/DOID_6713,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3454,,,,UMLS_CUI:C0751955|MESH:D020520,,,disease_ontology,,DOID:3454,,,,,,,,,,,,,,,,,,,brain infarction,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3138,"[""acanthosis nigricans""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_10123,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3138,,,,UMLS_CUI:C0000889|SNOMEDCT_US_2016_03_01:72129000|MESH:D000052|SNOMEDCT_US_2016_03_01:402599005|OMIM:200170|NCI:C26687|ICD10CM:L83|OMIM:100600,keratosis nigricans|AN - Acanthosis nigricans|Acanthosis nigricans (disorder)|Keratosis nigricans,,disease_ontology,,DOID:3138,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,acanthosis nigricans,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000128,"[""MET146 in JNK3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000128,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET146 in JNK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000177,"[""Prokineticin-2beta""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000177,,,,,,,,,,,,,,,,,,,,,,,,,,,,Prokineticin-2beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000119,"[""MET132 in NUAK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000119,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET132 in NUAK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300460,"[""RYR1 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300354,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300460,,,,,,,,,,,,,,,,,,,,,,,,,,,,RYR1 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100372,"[""Bdnf/nt-3 growth factors receptor""]",,"BDNF/NT-3 growth factors receptor (TRKB)  with  no mutation  in a nonphosphorylated state|A BDNF/NT-3 growth factors receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16620] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300200,,,,,,,,"BDNF/NT-3 growth factors receptor (TRKB)  with  no mutation  in a nonphosphorylated state|A BDNF/NT-3 growth factors receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16620] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100372,,,,https://pharos.nih.gov/idg/targets/Q16620,,,,,,,,,,,,,NTRK2,TRKB,,Q16620,,,,,,,,Bdnf/nt-3 growth factors receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400535,"[""Kv1.4/KCNA4 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400436,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400535,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv1.4/KCNA4 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100565,"[""Putative olfactory receptor 4A4""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100565,,,,https://pharos.nih.gov/idg/targets/Q8NGN8,,,,,,,,,,,,,OR4A4P,,,Q8NGN8,,,,,,,,Putative olfactory receptor 4A4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117509,"[""Coup transcription factor 2""]",,"A COUP transcription factor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P24468] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117471,,,,,,,,"A COUP transcription factor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P24468] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117509,,,,https://pharos.nih.gov/idg/targets/P24468,,,,,,,,,,,,,NR2F2,TFCOUP2,,P24468,,,,,,,,Coup transcription factor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400017,"[""5-hydroxytryptamine receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400017,,,,,,,,,,,,,,,,,,,,,,,,,,,,5-hydroxytryptamine receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002975,"[""A-2058 cell""]",,"Human skin melanoma cell line, established from a 43 years adult caucasian male.",false,,,http://purl.obolibrary.org/obo/BTO_0000849|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Human skin melanoma cell line, established from a 43 years adult caucasian male.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002975,,,,,,,BrendaTissueOBO,A2058 cell,BTO:0002975,,,,,,,,,,,,,,,,,,,A-2058 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117493,"[""Bile acid receptor""]",,"A bile acid receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RI1] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117465,,,,,,,,"A bile acid receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RI1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117493,,,,https://pharos.nih.gov/idg/targets/Q96RI1,,,,,,,,,,,,,NR1H4,FXR,,Q96RI1,,,,,,,,Bile acid receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004210,"[""seminoma cell""]",,"A type of cancer of the testicles. Seminomas may spread to the lung, bone, liver, or brain.",false,,,http://purl.obolibrary.org/obo/BTO_0000279|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A type of cancer of the testicles. Seminomas may spread to the lung, bone, liver, or brain.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004210,,,,,,,BrendaTissueOBO,,BTO:0004210,,,,,,,,,,,,,,,,,,,seminoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200171,"[""HCK gene""]",,"The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400132,,,,,,,,"The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200171,,,,,,,,,,,,,,,,3055,HCK,,,,,,,,,,,HCK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100085,"[""CGMP-gated cation channel alpha-1""]",,"A cGMP-gated cation channel alpha-1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P29973] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300402,,,,,,,,"A cGMP-gated cation channel alpha-1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P29973] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100085,,,,https://pharos.nih.gov/idg/targets/P29973,,,,,,,,,,,,,CNGA1,CNCG|CNCG1,,P29973,,,,,,,,CGMP-gated cation channel alpha-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000334,"[""PGFRA kinase domain""]",,"Platelet-derived growth factor receptor, alpha polypeptide; CD140A; MGC74795; PDGFR2; PDGFR-2; PDGFRA; PDGFRalpha; PDGFR-alpha; RHEPDGFRA",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Platelet-derived growth factor receptor, alpha polypeptide; CD140A; MGC74795; PDGFR2; PDGFR-2; PDGFRA; PDGFRalpha; PDGFR-alpha; RHEPDGFRA",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000334,,,,,,,,,,,,,,,,,,,200312,,,,,,,,,PGFRA kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200127,"[""GPR101 gene""]",,"A G-protein coupled receptor 101 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P66] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400095,,,,,,,,"A G-protein coupled receptor 101 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P66] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200127,,,,,,,,,,,,,,,,83550,GPR101,,,,,,,,,,,GPR101 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200381,"[""OR4F15 gene""]",,"An olfactory receptor 4F15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4F15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200381,,,,,,,,,,,,,,,,390649,OR4F15,,,,,,,,,,,OR4F15 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001471,"[""yolk sac""]",,"A membranous sac that is attached to an embryo and encloses food yolk, that is continuous in most forms through the yolk stalk with the intestinal cavity of the embryo, that being abundantly supplied with blood vessels is throughout embryonic life and in some forms later the chief organ of nutrition, and that in placental mammals is nearly vestigial and functions chiefly prior to the elaboration of the placenta.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A membranous sac that is attached to an embryo and encloses food yolk, that is continuous in most forms through the yolk stalk with the intestinal cavity of the embryo, that being abundantly supplied with blood vessels is throughout embryonic life and in some forms later the chief organ of nutrition, and that in placental mammals is nearly vestigial and functions chiefly prior to the elaboration of the placenta.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001471,,,,,,,BrendaTissueOBO,,BTO:0001471,,,,,,,,,,,,,,,,,,,yolk sac,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4305,"[""bone giant cell tumor""]",,A giant cell tumor and bone cancer and bone tissue neoplasm that results_in the presence of multinucleated giant cells (osteoclast-like cell).,false,,,http://purl.obolibrary.org/obo/DOID_200,,,,,,,,A giant cell tumor and bone cancer and bone tissue neoplasm that results_in the presence of multinucleated giant cells (osteoclast-like cell).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4305,,,,UMLS_CUI:C0206638|SNOMEDCT_US_2016_03_01:189891002|SNOMEDCT_US_2016_03_01:697970009|NCI:C121932|MESH:D018212|SNOMEDCT_US_2016_03_01:57500000,Giant cell tumor of bone NOS (morphologic abnormality)|Giant cell neoplasm of bone|Giant cell tumor of bone (morphologic abnormality),,disease_ontology,osteoclastoma|giant cell myeloma,DOID:4305,,,,,,,,,,,,,,,,,,,bone giant cell tumor,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000596,"[""P-19 cell""]",,"Mouse embryonal carcinoma cell line, established from the teratocarcinoma induced in a C3H/He strain mouse.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000306|http://purl.obolibrary.org/obo/BTO_0001437,,,,,,,,"Mouse embryonal carcinoma cell line, established from the teratocarcinoma induced in a C3H/He strain mouse.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000596,,,,,,,BrendaTissueOBO,P19 cell,BTO:0000596,,,,,,,,,,,,,,,,,,,P-19 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003283,"[""SC-M1 cell""]",,The EBV negative SCM1 cell line was originally derived from the gastric specimen of a patient with poorly differentiated tubular adenocarcinoma of the stomach.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002380,,,,,,,,The EBV negative SCM1 cell line was originally derived from the gastric specimen of a patient with poorly differentiated tubular adenocarcinoma of the stomach.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003283,,,,,,,BrendaTissueOBO,SCM1 cell,BTO:0003283,,,,,,,,,,,,,,,,,,,SC-M1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1498,"[""cholera""]",,"A primary bacterial infectious disease that is described as an acute, diarrheal illness caused by infection of the intestine with the bacterium Vibrio cholerae, which is characterized by profuse watery diarrhea, vomiting, leg cramps, circulatory collapse and shock.",false,,,http://purl.obolibrary.org/obo/DOID_0050338,,,,,,,,"A primary bacterial infectious disease that is described as an acute, diarrheal illness caused by infection of the intestine with the bacterium Vibrio cholerae, which is characterized by profuse watery diarrhea, vomiting, leg cramps, circulatory collapse and shock.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1498,,,,ICD10CM:A00|MESH:D002771|ICD10CM:A00.0|ICD10CM:A00.9|SNOMEDCT_US_2016_03_01:186088002|ICD9CM:001|SNOMEDCT_US_2016_03_01:187267007|SNOMEDCT_US_2016_03_01:154269008|SNOMEDCT_US_2016_03_01:186087007|SNOMEDCT_US_2016_03_01:63650001|SNOMEDCT_US_2016_03_01:61972007|ICD9CM:001.0|SNOMEDCT_US_2016_03_01:186089005|UMLS_CUI:C0008354|ICD9CM:001.9,Cholera due to Vibrio cholerae|(Cholera) or (Vibrio cholerae)|Cholera - Vibrio cholerae (disorder),,disease_ontology,,DOID:1498,http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease|http://purl.obolibrary.org/obo/doid#GOLD|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,cholera,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217541,"[""RORB gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00217464,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217541,,,,,,,,,,,,,,,,,RORB,NR1F2|RZRB,,,,,,,,,,RORB gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10132,"[""psychosexual disorder""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060043,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10132,,,,ICD9CM:302.79|UMLS_CUI:C0033951,,,disease_ontology,,DOID:10132,,,,,,,,,,,,,,,,,,,psychosexual disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002906,"[""NPLC/PRF/5 cell""]",,A subline of the PLC/PRF/5 cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A subline of the PLC/PRF/5 cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002906,,,,,,,BrendaTissueOBO,NPLC cell,BTO:0002906,,,,,,,,,,,,,,,,,,,NPLC/PRF/5 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400228,"[""ULK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400228,,,,,,,,,,,,,,,,,,,,,,,,,,,,ULK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100069,"[""Cyclin-dependent kinase 3""]",,"A cyclin-dependent kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q00526] |cyclin-dependent kinase 3 (CDK3)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300258,,,,,,,,"A cyclin-dependent kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q00526] |cyclin-dependent kinase 3 (CDK3)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100069,,,,https://pharos.nih.gov/idg/targets/Q00526,,,,,,,,,,,,,CDK3,CDKN3,,Q00526,,,,,,,,Cyclin-dependent kinase 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300338,"[""ABCC family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300338,,,,,,,,,,,,,,,,,,,,,,,,,,,,ABCC family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002669,"[""peripheral blood stem cell""]",,Stem cells found in the peripheral blood rather than the bone marrow; their numbers can be artificially increased by exposure to hematopoietic growth factors so that they can be extracted before myeloablative chemotherapy and later infused as an autologous bone marrow transplantation.,false,,,http://purl.obolibrary.org/obo/BTO_0002666|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Stem cells found in the peripheral blood rather than the bone marrow; their numbers can be artificially increased by exposure to hematopoietic growth factors so that they can be extracted before myeloablative chemotherapy and later infused as an autologous bone marrow transplantation.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002669,,,,,,,BrendaTissueOBO,peripheral blood progenitor cell|PBPC|periphere Blutstammzelle,BTO:0002669,,,,,,,,,,,,,,,,,,,peripheral blood stem cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100326,"[""Mitogen-activated protein kinase 14""]",,"A mitogen-activated protein kinase 14 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q16539] |mitogen-activated protein kinase 14 (MK14)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300294,,,,,,,,"A mitogen-activated protein kinase 14 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q16539] |mitogen-activated protein kinase 14 (MK14)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100326,,,,https://pharos.nih.gov/idg/targets/Q16539,,,,,,,,,,,,,MAPK14,CSBP|CSBP1|CSBP2|CSPB1|MXI2|SAPK2A,,Q16539,,,,,,,,Mitogen-activated protein kinase 14,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300325,"[""Carbohydrate kinase""]",,A carbohydrate kinase is a kinase enzyme that catalyzes the phosphorylation of a carbohydrate substrate.,false,,,http://www.drugtargetontology.org/dto/DTO_03300103,,,,,,,,A carbohydrate kinase is a kinase enzyme that catalyzes the phosphorylation of a carbohydrate substrate.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300325,,,,,,,,,,,,,,,,,,,,,,,,,,,,Carbohydrate kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002901,"[""neural crest cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002901,,,,,,,BrendaTissueOBO,,BTO:0002901,,,,,,,,,,,,,,,,,,,neural crest cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100050,"[""Extracellular calcium-sensing receptor""]",,"An extracellular calcium-sensing receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41180] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300029,,,,,,,,"An extracellular calcium-sensing receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41180] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100050,,,,https://pharos.nih.gov/idg/targets/P41180,,,,,,,,,,,,,CASR,GPRC2A|PCAR1,,P41180,,,,,,,,Extracellular calcium-sensing receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200816,"[""AVPR1B gene""]",,"A vasopressin V1b receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47901] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A vasopressin V1b receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47901] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200816,,,,,,,,,,,,,,,,553,AVPR1B,AVPR3|VPR3,,,,,,,,,,AVPR1B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4552,"[""large cell carcinoma""]",,"A carcinoma that is composed of large, monotonous rounded or overtly polygonal-shaped cells with abundant cytoplasm.",false,,,http://purl.obolibrary.org/obo/DOID_305,,,,,,,,"A carcinoma that is composed of large, monotonous rounded or overtly polygonal-shaped cells with abundant cytoplasm.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4552,,,,UMLS_CUI:C0206704|NCI:C3780|SNOMEDCT_US_2016_03_01:22687000|SNOMEDCT_US_2016_03_01:189551005|MESH:D018287,,,disease_ontology,,DOID:4552,,,,,,,,,,,,,,,,,,,large cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300023,"[""Angiotensin receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300023,,,,,,,,,,,,,,,,,,,,,,,,,,,,Angiotensin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100090,"[""Adhesion G protein-coupled receptor E2""]",,"An EGF-like module-containing mucin-like hormone receptor-like 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UHX3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,"An EGF-like module-containing mucin-like hormone receptor-like 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UHX3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100090,,,,https://pharos.nih.gov/idg/targets/Q9UHX3,,,,,,,,,,,,,EMR2,ADGRE2,,Q9UHX3,,,,,,,,Adhesion G protein-coupled receptor E2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100367,"[""Olfactory receptor 2AT4""]",,"An olfactory receptor 2AT4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NND4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2AT4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NND4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100367,,,,https://pharos.nih.gov/idg/targets/A6NND4,,,,,,,,,,,,,OR2AT4,,,A6NND4,,,,,,,,Olfactory receptor 2AT4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003558,"[""REC-1 cell""]",,Human mantle cell lymphoma (B cell non-Hodgkin's lymphoma) cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002904|http://purl.obolibrary.org/obo/BTO_0001518,,,,,,,,Human mantle cell lymphoma (B cell non-Hodgkin's lymphoma) cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003558,,,,,,,BrendaTissueOBO,,BTO:0003558,,,,,,,,,,,,,,,,,,,REC-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002505,"[""anaplastic large cell lymphoma cell""]",,"An aggressive (rapidly progressing) type of non-Hodgkins lymphoma that is usually of the T-cell type. The cancer cells express a marker called CD30 or Ki-1 on the surface, and may appear in the lymph nodes, skin, bones, soft tissues, lungs, or liver.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000785,,,,,,,,"An aggressive (rapidly progressing) type of non-Hodgkins lymphoma that is usually of the T-cell type. The cancer cells express a marker called CD30 or Ki-1 on the surface, and may appear in the lymph nodes, skin, bones, soft tissues, lungs, or liver.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002505,,,,,,,BrendaTissueOBO,ALCL cell,BTO:0002505,,,,,,,,,,,,,,,,,,,anaplastic large cell lymphoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8857,"[""lupus erythematosus""]",,,false,,,http://purl.obolibrary.org/obo/DOID_417,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8857,,,,ICD10CM:L93.0|SNOMEDCT_US_2016_03_01:200944003|UMLS_CUI:C0409974|ICD10CM:L93|ICD9CM:695.4|SNOMEDCT_US_2016_03_01:200936003|NCI:C27153,lupus,,disease_ontology,,DOID:8857,,,,,,,,,,,,,,,,,,,lupus erythematosus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_119,"[""vaginal cancer""]",,A female reproductive system cancer that is located_in the vagina.,false,,,http://purl.obolibrary.org/obo/DOID_120,,,,,,,,A female reproductive system cancer that is located_in the vagina.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:119,,,DOID:1902,SNOMEDCT_US_2016_03_01:126921000|NCI:C3437|ICD10CM:C52|NCI:C7410|UMLS_CUI:C0042237|SNOMEDCT_US_2016_03_01:363445000|MESH:D014625|UMLS_CUI:C0042258|SNOMEDCT_US_2016_03_01:154534007|ICD9CM:184.0|SNOMEDCT_US_2016_03_01:188210000,malignant tumor of vagina (disorder)|vaginal tumor|malignant vaginal tumor|vagina neoplasm|neoplasm of vagina (disorder)|malignant neoplasm of vagina,,disease_ontology,,DOID:119,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,vaginal cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_118,"[""pericardial effusion""]",,A pericardium disease that is characterized by an abnormal accumulation of fluid in the pericardial cavity.,false,,,http://purl.obolibrary.org/obo/DOID_0050829,,,,,,,,A pericardium disease that is characterized by an abnormal accumulation of fluid in the pericardial cavity.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:118,,,,SNOMEDCT_US_2016_03_01:373945007|SNOMEDCT_US_2016_03_01:70370001|UMLS_CUI:C0031039|NCI:C3319|MESH:D010490,,,disease_ontology,,DOID:118,,,,,,,,,,,,,,,,,,,pericardial effusion,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_110,"[""lens disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5614,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:110,,,,SNOMEDCT_US_2016_03_01:194613002|UMLS_CUI:C0023308|SNOMEDCT_US_2016_03_01:194158009|SNOMEDCT_US_2016_03_01:10810001|ICD10CM:H27.9|NCI:C26812|ICD10CM:H25-H28|MESH:D007905,,,disease_ontology,,DOID:110,,,,,,,,,,,,,,,,,,,lens disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_114,"[""heart disease""]",,A cardiovascular system disease that involves the heart.,false,,,http://purl.obolibrary.org/obo/DOID_1287,,,,,,,,A cardiovascular system disease that involves the heart.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:114,,,,SNOMEDCT_US_2016_03_01:266311004|SNOMEDCT_US_2016_03_01:56265001|NCI:C3079|UMLS_CUI:C0018799|ICD10CM:I51.9|MESH:D006331|SNOMEDCT_US_2016_03_01:155263000|ICD9CM:429.9|SNOMEDCT_US_2016_03_01:195152001|SNOMEDCT_US_2016_03_01:194707003|SNOMEDCT_US_2016_03_01:266275004,,,disease_ontology,,DOID:114,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,heart disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_117,"[""heart cancer""]",,A cardiovascular cancer located_in the heart.,false,,,http://purl.obolibrary.org/obo/DOID_176|http://purl.obolibrary.org/obo/DOID_114,,,,,,,,A cardiovascular cancer located_in the heart.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:117,,,DOID:9918,UMLS_CUI:C0018809|ICD10CM:C38.0|ICD9CM:164.1|NCI:C3081|SNOMEDCT_US_2016_03_01:126730001|UMLS_CUI:C0153500|SNOMEDCT_US_2016_03_01:363435002|SNOMEDCT_US_2016_03_01:187886009|NCI:C3548|SNOMEDCT_US_2016_03_01:93825008|SNOMEDCT_US_2016_03_01:154555009|SNOMEDCT_US_2016_03_01:387842002|MESH:D006338|SNOMEDCT_US_2016_03_01:269615000,Cardiac tumor|malignant neoplasm of heart|malignant Cardiac tumor|Tumour of heart,,disease_ontology,,DOID:117,,,,,,,,,,,,,,,,,,,heart cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_112,"[""esophageal varix""]",,,false,,,http://purl.obolibrary.org/obo/DOID_866,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:112,,,DOID:13536|DOID:111|DOID:14031,UMLS_CUI:C0155792|SNOMEDCT_US_2016_03_01:195475003|SNOMEDCT_US_2016_03_01:195474004|SNOMEDCT_US_2016_03_01:195643006|SNOMEDCT_US_2016_03_01:236067006|SNOMEDCT_US_2016_03_01:17709002|UMLS_CUI:C0155791|ICD9CM:456.20|ICD9CM:456.2|NCI:C78282|ICD10CM:I85.01|UMLS_CUI:C0155789|ICD9CM:456.0|SNOMEDCT_US_2016_03_01:195479009,"esophageal varices with bleeding in disease EC (disorder)|esophageal varices with bleeding|esophageal varices without mention of bleeding|esophageal varices without bleeding (disorder)|esophageal varices|esophageal varices in disease classified elsewhere, with bleeding|esophageal varices without bleeding|Bleeding oesophageal varices|Bleeding esophageal varices (disorder)|Bleeding esophageal varices",,disease_ontology,,DOID:112,,,,,,,,,,,,,,,,,,,esophageal varix,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050834,"[""CHARGE syndrome""]",,"A syndrome that is acterized by a pattern of congenital anomalies including choanal atresia and malformations of the heart, inner ear, and retina.",false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,"A syndrome that is acterized by a pattern of congenital anomalies including choanal atresia and malformations of the heart, inner ear, and retina.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050834,lschriml,2014-03-18T11:58:38Z,,MESH:D058747|UMLS_CUI:C2936502|ICD10:Q89.8|UMLS_CUI:C0265354|NCI:C75100|SNOMEDCT_US_2016_03_01:394529000|OMIM:214800|ORDO:138|SNOMEDCT_US_2016_03_01:47535005,CHARGE association,,disease_ontology,,DOID:0050834,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,CHARGE syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050836,"[""focal dystonia""]",,A dystonia that is localized to a specific part of the body.,false,,,http://purl.obolibrary.org/obo/DOID_543,,,,,,,,A dystonia that is localized to a specific part of the body.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050836,lschriml,2014-03-18T01:13:36Z,,,,,disease_ontology,,DOID:0050836,,,,,,,,,,,,,,,,,,,focal dystonia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050835,"[""generalized dystonia""]",,A dystonia that affects most or all of the body.,false,,,http://purl.obolibrary.org/obo/DOID_543,,,,,,,,A dystonia that affects most or all of the body.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050835,lschriml,2014-03-18T01:13:36Z,DOID:5159|DOID:11912|DOID:531|DOID:11910|DOID:11911|DOID:14164,SNOMEDCT_US_2016_03_01:230318005|SNOMEDCT_US_2016_03_01:192859002|SNOMEDCT_US_2016_03_01:192858005|UMLS_CUI:C0393598|ICD9CM:333.6|ICD10CM:G24.2|SNOMEDCT_US_2016_03_01:57937000|SNOMEDCT_US_2016_03_01:192853001|UMLS_CUI:C0154674|SNOMEDCT_US_2016_03_01:267584007|ICD10CM:G24.1|SNOMEDCT_US_2016_03_01:55776008|SNOMEDCT_US_2016_03_01:192852006|NCI:C35437|MESH:D004422|NCI:C35527|NCI:C35438|SNOMEDCT_US_2016_03_01:155008004|SNOMEDCT_US_2016_03_01:22451001|SNOMEDCT_US_2016_03_01:431034009|UMLS_CUI:C0013423|UMLS_CUI:C0393601|MESH:D020821|SNOMEDCT_US_2016_03_01:192862004|NCI:C34564|ICD9CM:333.8|UMLS_CUI:C0154675|SNOMEDCT_US_2016_03_01:230321007|UMLS_CUI:C0752207,dystonia musculorum deformans|idiopathic familial dystonia|familial dystonia|Idiopathic torsion dystonia|idiopathic non-familial dystonia|dystonia deformans progressiva|symptomatic torsion dystonia|fragments of torsion dystonia,,disease_ontology,Dystonia 12,DOID:0050835,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,MESH:C538001 added from NeuroDevNet [WAK].,,generalized dystonia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050830,"[""peripheral artery disease""]",,"An artery disease that is characterized by build up of plaque in the arteries that carry blood to your head, organs, and limbs.",false,,,http://purl.obolibrary.org/obo/DOID_0050828,,,,,,,,"An artery disease that is characterized by build up of plaque in the arteries that carry blood to your head, organs, and limbs.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050830,lschriml,2014-02-18T12:41:09Z,,,,,disease_ontology,,DOID:0050830,,,,,,,,,,,,,,,,,,,peripheral artery disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200380,"[""OR4C46 gene""]",,"An olfactory receptor 4C46 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NHA9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4C46 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NHA9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200380,,,,,,,,,,,,,,,,119749,OR4C46,,,,,,,,,,,OR4C46 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300350,"[""Golgi pH regulator family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300350,,,,,,,,,,,,,,,,,,,,,,,,,,,,Golgi pH regulator family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100010,"[""5-hydroxytryptamine receptor 5a""]",,"A 5-hydroxytryptamine receptor 5A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47898] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302004,,,,,,,,"A 5-hydroxytryptamine receptor 5A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47898] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100010,,,,https://pharos.nih.gov/idg/targets/P47898,,,,,,,,,,,,,HTR5A,,,P47898,,,,,,,,5-hydroxytryptamine receptor 5a,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400350,"[""Golgi pH regulator family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400350,,,,,,,,,,,,,,,,,,,,,,,,,,,,Golgi pH regulator family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000112,"[""DDR2 kinase domain""]",,Discoidin domain receptor tyrosine kinase 2; DDR2; MIG20a; NTRKR3; TKT; TYRO10,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Discoidin domain receptor tyrosine kinase 2; DDR2; MIG20a; NTRKR3; TKT; TYRO10,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000112,,,,,,,,,,,,,,,,,,,200113,,,,,,,,,DDR2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001311,"[""corpus striatum""]",,Either of a pair of masses of nervous tissue within the brain that contain two large nuclei of gray matter separated by sheets of white matter.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Either of a pair of masses of nervous tissue within the brain that contain two large nuclei of gray matter separated by sheets of white matter.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001311,,,,,,,BrendaTissueOBO,striated body|striatum|striate body,BTO:0001311,,,,,,,,,,,,,,,,,,,corpus striatum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200156,"[""GPR153 gene""]",,"A G-protein coupled receptor 153 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q6NV75] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400052,,,,,,,,"A G-protein coupled receptor 153 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q6NV75] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200156,,,,,,,,,,,,,,,,387509,GPR153,PGR1,,,,,,,,,,GPR153 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200397,"[""OR51G2 gene""]",,"An olfactory receptor 51G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 51G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200397,,,,,,,,,,,,,,,,81282,OR51G2,,,,,,,,,,,OR51G2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100194,"[""Tyrosine-protein kinase itk/tsk""]",,"tyrosine-protein kinase itk/tsk (ITK)  with  no mutation  in a nonphosphorylated state|A tyrosine-protein kinase ITK/TSK that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q08881] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300133,,,,,,,,"tyrosine-protein kinase itk/tsk (ITK)  with  no mutation  in a nonphosphorylated state|A tyrosine-protein kinase ITK/TSK that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q08881] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100194,,,,https://pharos.nih.gov/idg/targets/Q08881,,,,,,,,,,,,,ITK,EMT|LYK,,Q08881,,,,,,,,Tyrosine-protein kinase itk/tsk,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400592,"[""TRPV3 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400484,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400592,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPV3 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100167,"[""Inositol 1,4,5-trisphosphate receptor type 3""]",,"An inositol 1,4,5-trisphosphate receptor type 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14573] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300354,,,,,,,,"An inositol 1,4,5-trisphosphate receptor type 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14573] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100167,,,,https://pharos.nih.gov/idg/targets/Q14573,,,,,,,,,,,,,ITPR3,,,Q14573,,,,,,,,"Inositol 1,4,5-trisphosphate receptor type 3",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002886,"[""renal epithelium cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002886,,,,,,,BrendaTissueOBO,kidney epithelium cell line,BTO:0002886,,,,,,,,,,,,,,,,,,,renal epithelium cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003231,"[""SHG-44 cell""]",,Human glioma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000711,,,,,,,,Human glioma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003231,,,,,,,BrendaTissueOBO,SHG44 cell,BTO:0003231,,,,,,,,,,,,,,,,,,,SHG-44 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001686,"[""joint""]",,The point of contact between elements of an animal skeleton with the parts that surround and support it.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000421,,,,,,,,The point of contact between elements of an animal skeleton with the parts that surround and support it.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001686,,,,,,,BrendaTissueOBO,articular joint,BTO:0001686,,,,,,,,,,,,,,,,,,,joint,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11541,"[""recurrent corneal erosion""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1237,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11541,,,,ICD9CM:371.42|ICD10CM:H18.83|UMLS_CUI:C0155119|SNOMEDCT_US_2016_03_01:267732003|SNOMEDCT_US_2016_03_01:155157003|SNOMEDCT_US_2016_03_01:2055003,recurrent erosion of cornea|recurrent erosion syndrome,,disease_ontology,,DOID:11541,,,,,,,,,,,,,,,,,,,recurrent corneal erosion,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2855,"[""hyperthyroxinemia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_50,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2855,,,,UMLS_CUI:C0020551|MESH:D006981,,,disease_ontology,,DOID:2855,,,,,,,,,,,,,,,,,,,hyperthyroxinemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100137,"[""Ephrin type-b receptor 4""]",,"An ephrin type-B receptor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54760] |ephrin type-b receptor 4 (EPHB4)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300153,,,,,,,,"An ephrin type-B receptor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54760] |ephrin type-b receptor 4 (EPHB4)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100137,,,,https://pharos.nih.gov/idg/targets/P54760,,,,,,,,,,,,,EPHB4,HTK|MYK1|TYRO11,,P54760,,,,,,,,Ephrin type-b receptor 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003556,"[""SN-56 cell""]",,Murine septal cholinergic neuronal cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0000947|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Murine septal cholinergic neuronal cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003556,,,,,,,BrendaTissueOBO,SN56 cell,BTO:0003556,,,,,,,,,,,,,,,,,,,SN-56 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002709,"[""head and neck squamous cell carcinoma cell line""]",,Head and neck squamous cell carcinoma.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002024,,,,,,,,Head and neck squamous cell carcinoma.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002709,,,,,,,BrendaTissueOBO,HNSCC cell|neck squamous cell carcinoma cell line,BTO:0002709,,,,,,,,,,,,,,,,,,,head and neck squamous cell carcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000374,"[""THR670 in KIT(V559D,T670I)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000374,,,,,,,,,,,,,,,,,,,,,,,,,,,,"THR670 in KIT(V559D,T670I)",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100424,"[""Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform""]",,"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00329] |phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03391009,,,,,,,,"A phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00329] |phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100424,,,,https://pharos.nih.gov/idg/targets/O00329,,,,,,,,,,,,,PIK3CD,,,O00329,,,,,,,,"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100294,"[""Mitogen-activated protein kinase kinase kinase kinase 2""]",,"mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase kinase kinase kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q12851] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300287,,,,,,,,"mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase kinase kinase kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q12851] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100294,,,,https://pharos.nih.gov/idg/targets/Q12851,,,,,,,,,,,,,MAP4K2,GCK|RAB8IP,,Q12851,,,,,,,,Mitogen-activated protein kinase kinase kinase kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002580,"[""chronic myeloid leukemia cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000740,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002580,,,,,,,BrendaTissueOBO,chronic myelogenous leukemia cell line,BTO:0002580,,,,,,,,,,,,,,,,,,,chronic myeloid leukemia cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100210,"[""Probable g-protein coupled receptor 82""]",,"A G-protein coupled receptor 82 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P67] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300023,,,,,,,,"A G-protein coupled receptor 82 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P67] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100210,,,,https://pharos.nih.gov/idg/targets/Q96P67,,,,,,,,,,,,,GPR82,,,Q96P67,,,,,,,,Probable g-protein coupled receptor 82,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100201,"[""Potassium voltage-gated channel subfamily G member 1""]",,"A voltage-gated potassium channel KCNG1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9UIX4] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300549,,,,,,,,"A voltage-gated potassium channel KCNG1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9UIX4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100201,,,,https://pharos.nih.gov/idg/targets/Q9UIX4,,,,,,,,,,,,,KCNG1,,,Q9UIX4,,,,,,,,Potassium voltage-gated channel subfamily G member 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200363,"[""NEK9 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400197,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200363,,,,,,,,,,,,,,,,91754,NEK9,KIAA1995|NEK8|NERCC,,,,,,,,,,NEK9 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001876,"[""thyroid cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001876,,,,,,,BrendaTissueOBO,,BTO:0001876,,,,,,,,,,,,,,,,,,,thyroid cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200648,"[""OR5V1 gene""]",,"An olfactory receptor 5V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UGF6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UGF6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200648,,,,,,,,,,,,,,,,81696,OR5V1,,,,,,,,,,,OR5V1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000058,"[""LEU1538 in MYLK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000058,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU1538 in MYLK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050602,"[""triple-A syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050737,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050602,,,,OMIM:231550,Allgrove Syndrome|Achalasia-Addisonianism-Alacrimia syndrome,,disease_ontology,,DOID:0050602,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,triple-A syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050600,"[""ABCD syndrome""]",,"An autosomal recessive disease that is characterized by albinism, black lock, cell migration disorder of the neurocytes of the gut and sensorineural deafness and has_material_basis_in a mutation in the endothelin B receptor gene (EDNRB).",false,,,http://purl.obolibrary.org/obo/DOID_37|http://purl.obolibrary.org/obo/DOID_0050737,,,,,,,,"An autosomal recessive disease that is characterized by albinism, black lock, cell migration disorder of the neurocytes of the gut and sensorineural deafness and has_material_basis_in a mutation in the endothelin B receptor gene (EDNRB).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050600,,,,OMIM:600501,"albinism, block lock, cell migration disorder of the neurocytes of the gut, and deafness",,disease_ontology,,DOID:0050600,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,ABCD syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050608,"[""Askin's tumor""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3369,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050608,,,,,Askin tumor,,disease_ontology,,DOID:0050608,,,,,,,,,,,,,,,,,,,Askin's tumor,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200368,"[""OR2T10 gene""]",,"An olfactory receptor 2T10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2T10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200368,,,,,,,,,,,,,,,,127069,OR2T10,,,,,,,,,,,OR2T10 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217547,"[""NR1I2 gene""]",,"This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_00217466,,,,,,,,"This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217547,,,,,,,,,,,,,,,,8856,NR1I2,PXR,,,,,,,,,,NR1I2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217570,"[""NR4A1 gene""]",,"This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_00217475,,,,,,,,"This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217570,,,,,,,,,,,,,,,,3164,NR4A1,GFRP1|HMR|NAK1,,,,,,,,,,NR4A1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100767,"[""Sphingosine 1-phosphate receptor 5""]",,"A sphingosine 1-phosphate receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H228] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A sphingosine 1-phosphate receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H228] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100767,,,,https://pharos.nih.gov/idg/targets/Q9H228,,,,,,,,,,,,,S1PR5,EDG8,,Q9H228,,,,,,,,Sphingosine 1-phosphate receptor 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8564,"[""lip cancer""]",,,false,,,http://purl.obolibrary.org/obo/DOID_8618|http://purl.obolibrary.org/obo/DOID_9297,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8564,,,DOID:8975|DOID:9135|DOID:8605|DOID:9031|DOID:8563,ICD10CM:C00.9|SNOMEDCT_US_2016_03_01:309808004|MESH:D008048|SNOMEDCT_US_2016_03_01:187599002|SNOMEDCT_US_2016_03_01:187626009|UMLS_CUI:C0153346|ICD10CM:C00|UMLS_CUI:C0153347|SNOMEDCT_US_2016_03_01:187625008|SNOMEDCT_US_2016_03_01:363374005|ICD9CM:140.8|SNOMEDCT_US_2016_03_01:93869001|ICD9CM:140.6|SNOMEDCT_US_2016_03_01:363348004|NCI:C7485|UMLS_CUI:C0153340|SNOMEDCT_US_2016_03_01:93762003|ICD9CM:140,"malignant neoplasm of vermilion border of lip unspecified (disorder)|malignant neoplasm of lip, unspecified (disorder)|malignant neoplasm of external Lip, not specified as upper or lower|malignant neoplasm of vermilion border of lip|malignant neoplasm of lip, unspecified, vermilion border|malignant tumor of commissure of lip (disorder)|malignant tumor of lip (disorder)|malignant tumour of labial commissure|malignant neoplasm of lip, vermilion border NOS (disorder)|malignant neoplasm of lower lip, inner aspect NOS (disorder)|malignant neoplasm of lip, inner aspect NOS (disorder)|malignant neoplasm of lower lip, oral aspect|malignant neoplasm of other sites of lip|malignant neoplasm of lip, inner aspect|malignant neoplasm of lip, unspecified|malignant neoplasm of lip, unspecified, external (disorder)|malignant neoplasm of lip unspecified, inner aspect (disorder)|malignant tumor of the Lip|malignant tumor of commissure of lip|malignant neoplasm of lower lip, buccal aspect (disorder)|malignant tumor of labial mucosa (disorder)|malignant neoplasm of lip, unspecified, inner aspect|malignant neoplasm of commissure of lip|malignant neoplasm of lower lip, mucosa (disorder)|malignant tumour of lip|malignant tumor of lower labial mucosa (disorder)|malignant neoplasm of oral aspect of lip, not specified whether upper or lower|malignant neoplasm of other sites of lip (disorder)|malignant neoplasm of labial commissure of lip",,disease_ontology,,DOID:8564,,,,,,,,,,,,,,,,,,,lip cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300017,"[""5-hydroxytryptamine receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300017,,,,,,,,,,,,,,,,,,,,,,,,,,,,5-hydroxytryptamine receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000432,"[""VAL927 in FLT4""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000432,,,,,,,,,,,,,,,,,,,,,,,,,,,,VAL927 in FLT4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100535,"[""Olfactory receptor 2L3""]",,"An olfactory receptor 2L3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG85] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2L3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG85] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100535,,,,https://pharos.nih.gov/idg/targets/Q8NG85,,,,,,,,,,,,,OR2L3,,,Q8NG85,,,,,,,,Olfactory receptor 2L3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/UBERON_0001016,"[""nervous system""]",nerve net,"The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO].",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062,,relationship type change: differentiates_from ectoderm (AAO:0000137) CHANGED TO: develops_from ectoderm (UBERON:0000924)[AAO],,,,,http://www.snomedbrowser.com/Codes/Details/278196006|http://en.wikipedia.org/wiki/Nervous_system|http://linkedlifedata.com/resource/umls/id/C0027763|AAO:0000324|EV:0100162|ZFA:0000396|UMLS:C0027763|BTO:0001484|EMAPA:16469|EFO:0000802|NeuroNames:3236|MAT:0000026|VHOG:0000402|MIAA:0000026|MESH:A08|NIF_GrossAnatomy:birnlex_844|EHDAA:826|XAO:0000177|CALOHA:TS-1313|TAO:0000396|GAID:466|FBbt:00005093|FMA:7157|OpenCyc:Mx4rvViT_pwpEbGdrcN5Y29ycA|EHDAA2:0001246|MA:0000016|WBbt:0005735|BILA:0000079|ncithesaurus:Nervous_System,"The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO].",,http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg|http://upload.wikimedia.org/wikipedia/commons/thumb/b/ba/Nervous_system_diagram.png/200px-Nervous_system_diagram.png,,,,,,,,"Anatomical system consisting of nerve bodies and nerve fibers which regulate the response of the body to external and internal stimuli.[AAO]|A regulatory system of the body that consists of neurons and neuroglial cells. The nervous system is divided into two parts, the central nervous system (CNS) and the peripheral nervous system (PNS). (Source: BioGlossary, www.Biology-Text.com)[TAO]",,,,,,,,,,,,,,,,,,,,,,,,,,,nerve net,uberon,systema nervosum|Nervensystem,nervous|neural,Nervous systems evolved in the ancestor of Eumetazoa.[well established][VHOG],,,,,,,,,,,,,,,,,,,,,,,,UBERON:0001016,,,,,nervous system,,UBERON:0001016,,http://purl.obolibrary.org/obo/uberon.owl,http://purl.obolibrary.org/obo/uberon/core#efo_slim|http://purl.obolibrary.org/obo/uberon/core#cumbo|http://purl.obolibrary.org/obo/uberon/core#vertebrate_core|http://purl.obolibrary.org/obo/uberon/core#uberon_slim,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400316,"[""LKB subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400116,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400316,,,,,,,,,,,,,,,,,,,,,,,,,,,,LKB subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2033,"[""communication disorder""]",,A specific developmental disorder that involves specific developmental disorders of speech and language.,false,,,http://purl.obolibrary.org/obo/DOID_0060038,,,,,,,,A specific developmental disorder that involves specific developmental disorders of speech and language.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2033,,,,ICD10CM:F80.9|UMLS_CUI:C0009460|SNOMEDCT_US_2016_03_01:278919001|MESH:D003147|NCI:C2958|SNOMEDCT_US_2016_03_01:74825008,,,disease_ontology,,DOID:2033,,,,,,,,,,,,,,,,,,,communication disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200099,"[""FPR2 gene""]",,"An N-formyl peptide receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25090] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400041,,,,,,,,"An N-formyl peptide receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25090] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200099,,,,,,,,,,,,,,,,2358,FPR2,FPRH1|FPRL1|LXA4R,,,,,,,,,,FPR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100486,"[""Olfactory receptor 1e3""]",,"An olfactory receptor 1E3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZA6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1E3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZA6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100486,,,,https://pharos.nih.gov/idg/targets/Q8WZA6,,,,,,,,,,,,,OR1E3,OR1E3P,,Q8WZA6,,,,,,,,Olfactory receptor 1e3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200639,"[""OR5M9 gene""]",,"An olfactory receptor 5M9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5M9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200639,,,,,,,,,,,,,,,,390162,OR5M9,,,,,,,,,,,OR5M9 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2187,"[""amelogenesis imperfecta""]",,A dental enamel hypoplasia characterized by abnormal enamel formation.,false,,,http://purl.obolibrary.org/obo/DOID_693,,,,,,,,A dental enamel hypoplasia characterized by abnormal enamel formation.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2187,,,,ICD10CM:K00.5|MESH:D000567|CSP:0828-0533|SNOMEDCT_US_2016_03_01:78494001|OMIM:PS104500|UMLS_CUI:C0002452|ORDO:88661,,,disease_ontology,,DOID:2187,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,amelogenesis imperfecta,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100157,"[""ATP-sensitive inward rectifier potassium channel 1""]",,"An ATP-sensitive inward rectifier potassium channel 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48048] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300428,,,,,,,,"An ATP-sensitive inward rectifier potassium channel 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48048] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100157,,,,https://pharos.nih.gov/idg/targets/P48048,,,,,,,,,,,,,KCNJ1,ROMK1,,P48048,,,,,,,,ATP-sensitive inward rectifier potassium channel 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200801,"[""TAAR1 gene""]",,"A trace amine-associated receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96RJ0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A trace amine-associated receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96RJ0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200801,,,,,,,,,,,,,,,,134864,TAAR1,TA1|TAR1|TRAR1,,,,,,,,,,TAAR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100073,"[""Chloride channel protein 2""]",,"A chloride channel protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51788] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300396,,,,,,,,"A chloride channel protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51788] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100073,,,,https://pharos.nih.gov/idg/targets/P51788,,,,,,,,,,,,,CLCN2,,,P51788,,,,,,,,Chloride channel protein 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_17659,"[""UDP""]","Uridine 5'-pyrophosphorate|5'-UDP|XCCTYIAWTASOJW-XVFCMESISA-N|
O[C@@H]1[C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
|Uridine 5'-pyrophosphate|
[[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxyphosphonic acid
|Uridine 5'-diphosphate|Uridine 5'-pyrophosphoric acid|
[({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid
|
[[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxyphosphonic acid
|Uridine diphosphate|URIDINE-5'-DIPHOSPHATE|
InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
|Uridine pyrophosphate|uridine 5'-(trihydrogen diphosphate)|C9H14N2O12P2","
A pyrimidine ribonucleoside 5'-diphosphate that has formula C9H14N2O12P2.
",false,,,http://purl.obolibrary.org/obo/CHEBI_36976,,,,,,,CiteXplore:14558596|Wikipedia:UDP|KEGG COMPOUND:C00015|CiteXplore:19212411|DrugBank:DB03435|CiteXplore:11023036|CiteXplore:12351530|PDBeChem:UDP|KNApSAcK:C00007313|CiteXplore:9460170|KEGG GLYCAN:G10619|Wikipedia:Uridine_Diphosphate|ChemIDplus:58-98-0|KEGG COMPOUND:58-98-0|CiteXplore:1257952|MetaCyc:UDP|HMDB:HMDB00295|CiteXplore:15170365|Beilstein:64707,"
A pyrimidine ribonucleoside 5'-diphosphate that has formula C9H14N2O12P2.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:46402|CHEBI:13445|CHEBI:27230|CHEBI:9802,,uridine 5'-(trihydrogen diphosphate)|UDP,,chebi_ontology,"Uridine 5'-pyrophosphorate|5'-UDP|XCCTYIAWTASOJW-XVFCMESISA-N|
O[C@@H]1[C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
|Uridine 5'-pyrophosphate|
[[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxyphosphonic acid
|Uridine 5'-diphosphate|Uridine 5'-pyrophosphoric acid|
[({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid
|
[[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxyphosphonic acid
|Uridine diphosphate|URIDINE-5'-DIPHOSPHATE|
InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
|Uridine pyrophosphate|uridine 5'-(trihydrogen diphosphate)|C9H14N2O12P2",,,CHEBI:17659,,,,,,,,,,,,,,,,,,,,,,,CHEBI:17659,,,,,UDP,,CHEBI:17659,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1325,"[""bronchus cancer""]",,A respiratory system cancer that is located_in the bronchus.,false,,,http://purl.obolibrary.org/obo/DOID_0050615,,,,,,,,A respiratory system cancer that is located_in the bronchus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1325,,,,ICD9CM:162.9|ICD10CM:C34.9|ICD10CM:C34|SNOMEDCT_US_2016_03_01:269465004|SNOMEDCT_US_2016_03_01:190092003|UMLS_CUI:C0348343|SNOMEDCT_US_2016_03_01:187875007,"malignant neoplasm of bronchus or lung, unspecified (disorder)|malignant neoplasm of bronchus or lung NOS (disorder)|malignant neoplasm of bronchus and lung, unspecified",,disease_ontology,,DOID:1325,,,,,,,,,,,,,,,,,,,bronchus cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13250,"[""diarrhea""]",,"A gastrointestinal system disease described as the condition of having frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. The loss of fluids through diarrhea can cause severe dehydration which is one cause of death in diarrhea sufferers. Along with water, sufferers also lose dangerous amounts of important salts, electrolytes, and other nutrients. There are at least four types of diarrhea: secretory diarrhea, osmotic diarrhea, motility-related diarrhea, and inflammatory diarrhea.",false,,,http://purl.obolibrary.org/obo/DOID_77,,,,,,,,"A gastrointestinal system disease described as the condition of having frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. The loss of fluids through diarrhea can cause severe dehydration which is one cause of death in diarrhea sufferers. Along with water, sufferers also lose dangerous amounts of important salts, electrolytes, and other nutrients. There are at least four types of diarrhea: secretory diarrhea, osmotic diarrhea, motility-related diarrhea, and inflammatory diarrhea.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13250,,,DOID:0050006,UMLS_CUI:C0013369|SNOMEDCT_US_2016_03_01:266180003|SNOMEDCT_US_2016_03_01:154279005|MESH:D004403|SNOMEDCT_US_2016_03_01:111939009|SNOMEDCT_US_2016_03_01:186165000|SNOMEDCT_US_2016_03_01:186167008|ICD9CM:009.2|SNOMEDCT_US_2016_03_01:236076004|SNOMEDCT_US_2016_03_01:19213003|SNOMEDCT_US_2016_03_01:154268000|SNOMEDCT_US_2016_03_01:266173000,,,disease_ontology,diarrhea of presumed infectious origin|diarrhoea,DOID:13250,http://purl.obolibrary.org/obo/doid#GOLD,,,,,,,,,,,,,,,,,,diarrhea,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200148,"[""HVCN1 gene""]",,"This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400352,,,,,,,,"This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200148,,,,,,,,,,,,,,,,84329,HVCN1,VSOP,,,,,,,,,,HVCN1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000153,"[""ERN1 kinase domain""]",,Endoplasmic reticulum to nucleus signaling 1; ERN1; FLJ30999; hIRE1p; IRE1; IRE1a; IRE1P; MGC163277; MGC163279,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Endoplasmic reticulum to nucleus signaling 1; ERN1; FLJ30999; hIRE1p; IRE1; IRE1a; IRE1P; MGC163277; MGC163279,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000153,,,,,,,,,,,,,,,,,,,200157,,,,,,,,,ERN1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200171,"[""GPR32P1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200171,,,,,,,,,,,,,,,,2855,GPR32P1,,,,,,,,,,,GPR32P1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200489,"[""OR1F12 gene""]",,"An olfactory receptor 1F12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHA8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1F12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHA8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200489,,,,,,,,,,,,,,,,442179,OR1F12,OR1F12P,,,,,,,,,,OR1F12 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4415,"[""fibrous histiocytoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4231,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4415,,,,UMLS_CUI:C0206644|SNOMEDCT_US_2016_03_01:189769003|MESH:D018219|SNOMEDCT_US_2016_03_01:25889007|NCI:C3739|SNOMEDCT_US_2016_03_01:189770002,fibrous histiocytoma NOS (morphologic abnormality)|benign fibrous histiocytoma (morphologic abnormality)|fibrous Histiocytoma|Fibroxanthoma NOS (morphologic abnormality),,disease_ontology,,DOID:4415,,,,,,,,,,,,,,,,,,,fibrous histiocytoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050744,"[""anaplastic large cell lymphoma""]",,A non-Hodgkin lymphoma involving aberrant T-cells.,false,,,http://purl.obolibrary.org/obo/DOID_0060060,,,,,,,,A non-Hodgkin lymphoma involving aberrant T-cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050744,lschriml,2012-09-18T01:57:40Z,,,,,disease_ontology,,DOID:0050744,,,,,,,,,,,,,,,,,,,anaplastic large cell lymphoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050749,"[""peripheral T-cell lymphoma""]",,A mature T-cell and NK-cell lymphoma includes a group of T-cell lymphomas that develop away from the thymus.,false,,,http://purl.obolibrary.org/obo/DOID_0050743,,,,,,,,A mature T-cell and NK-cell lymphoma includes a group of T-cell lymphomas that develop away from the thymus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050749,lschriml,2012-09-18T02:01:49Z,,,,,disease_ontology,,DOID:0050749,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,peripheral T-cell lymphoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050742,"[""nicotine dependence""]",,,false,,,http://purl.obolibrary.org/obo/DOID_9973,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050742,lschriml,2012-09-05T11:48:42Z,,MESH:D014029|OMIM:188890|SNOMEDCT_US_2016_03_01:56294008|NCI:C54203|UMLS_CUI:C0028043|ICD10CM:F17.2|ICD10CM:F17.20|EFO:0003768|ICD10CM:F17,tobacco use disorder,,disease_ontology,,DOID:0050742,,,,,,,,,,,,,,,,,,,nicotine dependence,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050746,"[""mantle cell lymphoma""]",,A B-cell lymphocytic neoplasm due to CD5 positive antigen-naive pregerminal center B-cell within the mantle zone that surrounds normal germinal center follicles.,false,,,http://purl.obolibrary.org/obo/DOID_707,,,,,,,,A B-cell lymphocytic neoplasm due to CD5 positive antigen-naive pregerminal center B-cell within the mantle zone that surrounds normal germinal center follicles.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050746,lschriml,2012-09-18T02:00:45Z,,MESH:D020522,,,disease_ontology,,DOID:0050746,,,,,,,,,,,,,,,,,,,mantle cell lymphoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050741,"[""alcohol dependence""]",,,false,,,http://purl.obolibrary.org/obo/DOID_9973,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050741,lschriml,2012-09-05T11:48:42Z,,OMIM:103780|KEGG:05034|UMLS_CUI:C0031347|SNOMEDCT_US_2016_03_01:126685009|SNOMEDCT_US_2016_03_01:95001001|NCI:C3325|MESH:D010610|EFO:0003829,alcoholism,,disease_ontology,,DOID:0050741,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,alcohol dependence,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050745,"[""diffuse large B-cell lymphoma""]",,A B-cell lymphoma that is a cancer of B cells presenting as an aggressive tumour which can arise in virtually any part of the body.,false,,,http://purl.obolibrary.org/obo/DOID_707,,,,,,,,A B-cell lymphoma that is a cancer of B cells presenting as an aggressive tumour which can arise in virtually any part of the body.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050745,lschriml,2012-09-18T01:58:25Z,,,,,disease_ontology,,DOID:0050745,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,diffuse large B-cell lymphoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050743,"[""mature T-cell and NK-cell lymphoma""]",,A non-Hodgkin lymphoma that has_material_basis_in mature T lymphocytes and natural killer cells.,false,,,http://purl.obolibrary.org/obo/DOID_0060060,,,,,,,,A non-Hodgkin lymphoma that has_material_basis_in mature T lymphocytes and natural killer cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050743,lschriml,2012-09-18T01:56:52Z,,,NK-T cell lymphoma|mature T-cell and natural killer cell lymphoma,,disease_ontology,,DOID:0050743,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,mature T-cell and NK-cell lymphoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117487,"[""Peroxisome proliferator-activated receptor gamma""]",,"A peroxisome proliferator-activated receptor gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P37231] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117462,,,,,,,,"A peroxisome proliferator-activated receptor gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P37231] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117487,,,,https://pharos.nih.gov/idg/targets/P37231,,,,,,,,,,,,,PPARG,,,P37231,,,,,,,,Peroxisome proliferator-activated receptor gamma,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80336,"[""Insulin-like 3""]",Relaxin-like factor|INSL 3,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16124,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,Relaxin-like factor|INSL 3,,,CHEBI:80336,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80336,,,,,Insulin-like 3,,CHEBI:80336,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200111,"[""DMPK gene""]",,"The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400265,,,,,,,,"The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200111,,,,,,,,,,,,,,,,1760,DMPK,DM1PK|MDPK,,,,,,,,,,DMPK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000040,"[""LEU119 in KC1G2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000040,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU119 in KC1G2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2024,"[""placental choriocarcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2025,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2024,,,,SNOMEDCT_US_2016_03_01:448401007|UMLS_CUI:C0855173|NCI:C8893,Choriocarcinoma of the Placenta,,disease_ontology,,DOID:2024,,,,,,,,,,,,,,,,,,,placental choriocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200046,"[""BMX gene""]",,"This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400133,,,,,,,,"This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200046,,,,,,,,,,,,,,,,660,BMX,,,,,,,,,,,BMX gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300300,"[""NMO subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300191,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300300,,,,,,,,,,,,,,,,,,,,,,,,,,,,NMO subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100212,"[""G-protein coupled receptor 84""]",,"A G-protein coupled receptor 84 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NQS5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300058,,,,,,,,"A G-protein coupled receptor 84 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NQS5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100212,,,,https://pharos.nih.gov/idg/targets/Q9NQS5,,,,,,,,,,,,,GPR84,EX33,,Q9NQS5,,,,,,,,G-protein coupled receptor 84,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391008,"[""DCK/DGK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300322,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391008,,,,,,,,,,,,,,,,,,,,,,,,,,,,DCK/DGK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003359,"[""neointima""]",,A new or thickened layer of arterial intima formed especially on a prosthesis or in atherosclerosis by migration and proliferation of cells from the media.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A new or thickened layer of arterial intima formed especially on a prosthesis or in atherosclerosis by migration and proliferation of cells from the media.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003359,,,,,,,BrendaTissueOBO,,BTO:0003359,,,,,,,,,,,,,,,,,,,neointima,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12252,"[""Cushing's syndrome""]",,An adrenal gland hyperfunction that is caused by overactivity of the adrenal cortex caused by a tumor of the pituitary gland.,false,,,http://purl.obolibrary.org/obo/DOID_3947,,,,,,,,An adrenal gland hyperfunction that is caused by overactivity of the adrenal cortex caused by a tumor of the pituitary gland.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12252,,,,ICD10CM:E24|ICD10CM:E24.9|NCI:C2969|MESH:D003480|SNOMEDCT_US_2016_03_01:47270006|ICD9CM:255.0|SNOMEDCT_US_2016_03_01:190505004|SNOMEDCT_US_2016_03_01:154705004|UMLS_CUI:C0010481,Suprarenogenic syndrome|Cushing syndrome|pituitary basophilism,,disease_ontology,,DOID:12252,,,,,,,,,,,,,,,,,,,Cushing's syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100798,"[""Taste receptor type 2 member 8""]",,"A taste receptor type 2 member 8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300014,,,,,,,,"A taste receptor type 2 member 8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100798,,,,https://pharos.nih.gov/idg/targets/Q9NYW2,,,,,,,,,,,,,TAS2R8,,,Q9NYW2,,,,,,,,Taste receptor type 2 member 8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300398,"[""ClC-4/CLCN4 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300341,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300398,,,,,,,,,,,,,,,,,,,,,,,,,,,,ClC-4/CLCN4 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1188,"[""mononeuropathy""]",,"A neuropathy that is characterized by damage to a single nerve, which results in loss of movement, sensation, or other function of that nerve.",false,,,http://purl.obolibrary.org/obo/DOID_870,,,,,,,,"A neuropathy that is characterized by damage to a single nerve, which results in loss of movement, sensation, or other function of that nerve.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1188,,,,MESH:D020422|UMLS_CUI:C0494491|ICD10CM:G58.9|SNOMEDCT_US_2016_03_01:304595001|SNOMEDCT_US_2016_03_01:128189008,,,disease_ontology,,DOID:1188,,,,,,,,,,,,,,,,,,,mononeuropathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200495,"[""OR1K1 gene""]",,"An olfactory receptor 1K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200495,,,,,,,,,,,,,,,,392392,OR1K1,,,,,,,,,,,OR1K1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002553,"[""non-small cell lung cancer cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000762,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002553,,,,,,,BrendaTissueOBO,non small cell lung cancer cell line|NSCLC cell line,BTO:0002553,,,,,,,,,,,,,,,,,,,non-small cell lung cancer cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200392,"[""OR51E1 gene""]",,"An olfactory receptor 51E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TCB6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 51E1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TCB6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200392,,,,,,,,,,,,,,,,143503,OR51E1,GPR164|OR51E1P|OR52A3P|POGR|PSGR2,,,,,,,,,,OR51E1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000207,"[""MET82 in CSNK1E""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000207,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET82 in CSNK1E,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003230,"[""RL cell""]",,Human non-Hodgkin B cell lymphoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002904,,,,,,,,Human non-Hodgkin B cell lymphoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003230,,,,,,,BrendaTissueOBO,,BTO:0003230,,,,,,,,,,,,,,,,,,,RL cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300403,"[""CNGA2 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300343,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300403,,,,,,,,,,,,,,,,,,,,,,,,,,,,CNGA2 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001418,"[""urinary bladder""]",,A membranous sac in many vertebrates that serves for the temporary retention of urine and discharges by the urethra.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062|http://purl.obolibrary.org/obo/BTO_0000123,,,,,,,,A membranous sac in many vertebrates that serves for the temporary retention of urine and discharges by the urethra.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001418,,,,,,,BrendaTissueOBO,vesica,BTO:0001418,,,,,,,,,,,,,,,,,,,urinary bladder,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_16765,"[""tryptamine""]","160.21570|1H-indole-3-ethanamine|APJYDQYYACXCRM-UHFFFAOYSA-N|160.100|C10H12N2|NCCc1c[nH]c2ccccc12|InChI=1S/C10H12N2/c11-6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6,11H2|3-(2-Aminoethyl)indole|2-(3-indolyl)ethylamine|0|2-(1H-INDOL-3-YL)ETHANAMINE",An aminoalkylindole consisting of indole having a 2-aminoethyl group at the 3-position.,false,,,http://purl.obolibrary.org/obo/CHEBI_32952,,,,,,,PDBeChem:TSS|DrugBank:DB08653|Reaxys:125513|PMID:22770225|Wikipedia:Tryptamine|PMID:24558969|HMDB:HMDB00303|Beilstein:125513|CAS:61-54-1|MetaCyc:TRYPTAMINE|PMID:16126914|KNApSAcK:C00001434|Gmelin:603448|KEGG:C00398|PMID:24345948,An aminoalkylindole consisting of indole having a 2-aminoethyl group at the 3-position.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:46157|CHEBI:27161|CHEBI:15274|CHEBI:9767,,Tryptamine|2-(1H-indol-3-yl)ethanamine,,chebi_ontology,"160.21570|1H-indole-3-ethanamine|APJYDQYYACXCRM-UHFFFAOYSA-N|160.100|C10H12N2|NCCc1c[nH]c2ccccc12|InChI=1S/C10H12N2/c11-6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6,11H2|3-(2-Aminoethyl)indole|2-(3-indolyl)ethylamine|0|2-(1H-INDOL-3-YL)ETHANAMINE",,,CHEBI:16765,,,,,,,,,,,,,,,,,,,,,,,CHEBI:16765,,,,,tryptamine,,CHEBI:16765,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200667,"[""OR6P1 gene""]",,"An olfactory receptor 6P1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6P1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200667,,,,,,,,,,,,,,,,128366,OR6P1,,,,,,,,,,,OR6P1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200621,"[""OR5D16 gene""]",,"An olfactory receptor 5D16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5D16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200621,,,,,,,,,,,,,,,,390144,OR5D16,,,,,,,,,,,OR5D16 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1294,"[""vulva carcinoma""]",,A vulva cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.,false,,,http://purl.obolibrary.org/obo/DOID_1245|http://purl.obolibrary.org/obo/DOID_305,,,,,,,,A vulva cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1294,,,,NCI:C4866|UMLS_CUI:C0677055,Vulvar carcinoma,,disease_ontology,carcinoma of vulva,DOID:1294,,,,,,,,,,,,,,,,,,,vulva carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100189,"[""Potassium voltage-gated channel subfamily c member 1""]",,"A voltage-gated potassium channel KCNC1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P48547] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300541,,,,,,,,"A voltage-gated potassium channel KCNC1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P48547] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100189,,,,https://pharos.nih.gov/idg/targets/P48547,,,,,,,,,,,,,KCNC1,,,P48547,,,,,,,,Potassium voltage-gated channel subfamily c member 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1234,"[""gender identity disorder""]",,A disease of mental health that involves a conflict between a person's actual physical gender and the gender that person identifies himself or herself as.,false,,,http://purl.obolibrary.org/obo/DOID_150,,,,,,,,A disease of mental health that involves a conflict between a person's actual physical gender and the gender that person identifies himself or herself as.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1234,,,,ICD9CM:302.6|ICD9CM:302.89|UMLS_CUI:C0236802|SNOMEDCT_US_2016_03_01:5095008|ICD9CM:302.8|ICD9CM:302.85|UMLS_CUI:C0029825|UMLS_CUI:C0154467|ICD10CM:F64.2,,,disease_ontology,,DOID:1234,,,,,,,,,,,,,,,,,,,gender identity disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12347,"[""osteogenesis imperfecta""]",,An osteochondrodysplasia that has_material_basis_in a deficiency in type-I collagen which results_in brittle bones and defective connective tissue.,false,,,http://purl.obolibrary.org/obo/DOID_2256,,,,,,,,An osteochondrodysplasia that has_material_basis_in a deficiency in type-I collagen which results_in brittle bones and defective connective tissue.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12347,,,DOID:14708,SNOMEDCT_US_2016_03_01:205498009|SNOMEDCT_US_2016_03_01:254108007|SNOMEDCT_US_2016_03_01:254106006|SNOMEDCT_US_2016_03_01:3508009|NCI:C99003|ORDO:666|OMIM:PS166200|SNOMEDCT_US_2016_03_01:205492005|SNOMEDCT_US_2016_03_01:78314001|SNOMEDCT_US_2016_03_01:205494006|SNOMEDCT_US_2016_03_01:254105005|UMLS_CUI:C0029434|ICD10CM:Q78.0|UMLS_CUI:C0023931|SNOMEDCT_US_2016_03_01:385482004|SNOMEDCT_US_2016_03_01:157008000|ICD9CM:756.51|SNOMEDCT_US_2016_03_01:254109004|NCI:C26837|MESH:D010013|SNOMEDCT_US_2016_03_01:205493000|SNOMEDCT_US_2016_03_01:254107002|SNOMEDCT_US_2016_03_01:268352002,Lobstein's syndrome|brittle bone disease|Osteopsathyrosis|Vrolik's disease,,disease_ontology,Fragilitas ossium,DOID:12347,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,osteogenesis imperfecta,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1148,"[""polydactyly""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0080015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1148,,,DOID:14779,SNOMEDCT_US_2016_03_01:403562000|UMLS_CUI:C0220697|MESH:C562429|SNOMEDCT_US_2016_03_01:367506006|SNOMEDCT_US_2016_03_01:156988007|UMLS_CUI:C0152427|SNOMEDCT_US_2016_03_01:205136002|SNOMEDCT_US_2016_03_01:74537000|SNOMEDCT_US_2016_03_01:205119005|SNOMEDCT_US_2016_03_01:205120004|NCI:C87110|ICD10CM:Q69|MESH:D017689|OMIM:174200|OMIM:603596|OMIM:174700|ICD9CM:755.00|OMIM:174500|ICD9CM:755.0|ICD10CM:Q69.9,postaxial polydactyly,,disease_ontology,Supernumerary digit,DOID:1148,,,,,,,,,,,,,,,,,,,polydactyly,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11486,"[""Horner's syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_11504,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11486,,,,SNOMEDCT_US_2016_03_01:271730003|ICD10CM:G90.2|MESH:D006732|SNOMEDCT_US_2016_03_01:192922002|NCI:C28155|SNOMEDCT_US_2016_03_01:12731000|SNOMEDCT_US_2016_03_01:192915005|UMLS_CUI:C0019937,Bernard Horner syndrome|cervical sympathetic paralysis|Horner syndrome,,disease_ontology,,DOID:11486,,,,,,,,,,,,,,,,,,,Horner's syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11482,"[""hemopericardium""]",,A pericardial effusion that results from blood in the pericardial sac.,false,,,http://purl.obolibrary.org/obo/DOID_118,,,,,,,,A pericardial effusion that results from blood in the pericardial sac.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11482,,,,SNOMEDCT_US_2016_03_01:155339006|NCI:C111644|ICD9CM:423.0|UMLS_CUI:C0019064|SNOMEDCT_US_2016_03_01:23412002|MESH:D010490,Haemopericardium,,disease_ontology,,DOID:11482,,,,,,,,,,,,,,,,,,,hemopericardium,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000046,"[""C3a""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000046,,,,,,,,,,,,,,,,,,,,,,,,,,,,C3a,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004522,"[""Leydig cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0004229,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004522,mgr,2010-02-11T08:07:47Z,,,,,BrendaTissueOBO,,BTO:0004522,,,,,,,,,,,,,,,,,,,Leydig cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200054,"[""CCR2 gene""]",,"A C-C chemokine receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41597] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400095,,,,,,,,"A C-C chemokine receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41597] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200054,,,,,,,,,,,,,,,,729230,CCR2,CMKBR2,,,,,,,,,,CCR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200734,"[""P2RY13 gene""]",,"A P2Y purinoceptor 13 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BPV8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400100,,,,,,,,"A P2Y purinoceptor 13 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BPV8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200734,,,,,,,,,,,,,,,,53829,P2RY13,GPR86|GPR94,,,,,,,,,,P2RY13 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200399,"[""OR51I1 gene""]",,"An olfactory receptor 51I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H343] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 51I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H343] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200399,,,,,,,,,,,,,,,,390063,OR51I1,,,,,,,,,,,OR51I1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200038,"[""ACVR2A gene""]",,"This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400252,,,,,,,,"This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200038,,,,,,,,,,,,,,,,92,ACVR2A,ACVR2,,,,,,,,,,ACVR2A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100269,"[""Melatonin-related receptor""]",,"A melatonin-related receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13585] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A melatonin-related receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13585] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100269,,,,https://pharos.nih.gov/idg/targets/Q13585,,,,,,,,,,,,,GPR50,,,Q13585,,,,,,,,Melatonin-related receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200262,"[""SYK gene""]",,"This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400180,,,,,,,,"This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200262,,,,,,,,,,,,,,,,6850,SYK,,,,,,,,,,,SYK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200248,"[""LTB4R gene""]",,"A leukotriene B4 receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15722] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400033,,,,,,,,"A leukotriene B4 receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15722] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200248,,,,,,,,,,,,,,,,1241,LTB4R,BLT|BLT1|BLTR|CMKRL1|GPR16|P2RY7,,,,,,,,,,LTB4R gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000103,"[""MET108 in MK09""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000103,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET108 in MK09,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200071,"[""CLCNKB gene""]",,"The protein encoded by this gene is a member of the family of voltage-gated chloride channels. Chloride channels have several functions, including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. This gene is expressed predominantly in the kidney and may be important for renal salt reabsorption. Mutations in this gene are associated with autosomal recessive Bartter syndrome type 3 (BS3). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400394,,,,,,,,"The protein encoded by this gene is a member of the family of voltage-gated chloride channels. Chloride channels have several functions, including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. This gene is expressed predominantly in the kidney and may be important for renal salt reabsorption. Mutations in this gene are associated with autosomal recessive Bartter syndrome type 3 (BS3). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200071,,,,,,,,,,,,,,,,1188,CLCNKB,,,,,,,,,,,CLCNKB gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000418,"[""SRPK3 kinase domain""]",,SFRS protein kinase 3; MGC102944; MSSK1; SRPK3; STK23,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,SFRS protein kinase 3; MGC102944; MSSK1; SRPK3; STK23,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000418,,,,,,,,,,,,,,,,,,,200419,,,,,,,,,SRPK3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1074,"[""kidney failure""]",,A kidney disease characterized by the failure of the kidneys to adequately filter waste products from the blood.,false,,,http://purl.obolibrary.org/obo/DOID_557,,,,,,,,A kidney disease characterized by the failure of the kidneys to adequately filter waste products from the blood.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1074,,,,SNOMEDCT_US_2016_03_01:197656003|ICD10CM:N19|NCI:C4376|SNOMEDCT_US_2016_03_01:156092003|UMLS_CUI:C0035078|SNOMEDCT_US_2016_03_01:266616000|MESH:D051437|ICD9CM:586|SNOMEDCT_US_2016_03_01:266553002|SNOMEDCT_US_2016_03_01:198524000|SNOMEDCT_US_2016_03_01:42399005,renal failure,,disease_ontology,,DOID:1074,,,,,,,,,,,,,,,,,PRISM.,,kidney failure,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10747,"[""lymphoid leukemia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1037,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10747,,,,SNOMEDCT_US_2016_03_01:190035004|SNOMEDCT_US_2016_03_01:188726003|SNOMEDCT_US_2016_03_01:33560006|UMLS_CUI:C0152271|ICD9CM:204.2|SNOMEDCT_US_2016_03_01:154590001|SNOMEDCT_US_2016_03_01:95274002,subacute lymphoid leukemia,,disease_ontology,,DOID:10747,,,,,,,,,,,,,,,,,,,lymphoid leukemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100036,"[""L804 in RET(V804L)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100036,,,,,,,,,,,,,,,,,,,,,,,,,,,,L804 in RET(V804L),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3314,"[""angiomyolipoma""]",,A cell type benign neoplasm that from perivascular epithelioid cells.,false,,,http://purl.obolibrary.org/obo/DOID_0060084,,,,,,,,A cell type benign neoplasm that from perivascular epithelioid cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3314,,,,UMLS_CUI:C0206633|SNOMEDCT_US_2016_03_01:19929002|NCI:C3734|MESH:D018207,Angiomyolipoma (morphologic abnormality),,disease_ontology,,DOID:3314,,,,,,,,,,,,,,,,,,,angiomyolipoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100041,"[""Voltage-dependent l-type calcium channel subunit alpha-1d""]",,"A voltage-dependent L-type calcium channel subunit alpha-1D that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q01668] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300384,,,,,,,,"A voltage-dependent L-type calcium channel subunit alpha-1D that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q01668] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100041,,,,https://pharos.nih.gov/idg/targets/Q01668,,,,,,,,,,,,,CACNA1D,CACH3|CACN4|CACNL1A2|CCHL1A2,,Q01668,,,,,,,,Voltage-dependent l-type calcium channel subunit alpha-1d,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200333,"[""MOS gene""]",,"MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400193,,,,,,,,"MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200333,,,,,,,,,,,,,,,,4342,MOS,,,,,,,,,,,MOS gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100023,"[""Muscarinic acetylcholine receptor m3""]",,"A muscarinic acetylcholine receptor M3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P20309] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300020,,,,,,,,"A muscarinic acetylcholine receptor M3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P20309] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100023,,,,https://pharos.nih.gov/idg/targets/P20309,,,,,,,,,,,,,CHRM3,,,P20309,,,,,,,,Muscarinic acetylcholine receptor m3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100251,"[""Proto-oncogene Mas""]",,"A G-protein coupled receptor MAS that is encoded in the genome of human. [PRO:WCB, UniProtKB:P04201] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300063,,,,,,,,"A G-protein coupled receptor MAS that is encoded in the genome of human. [PRO:WCB, UniProtKB:P04201] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100251,,,,https://pharos.nih.gov/idg/targets/P04201,,,,,,,,,,,,,MAS1,MAS,,P04201,,,,,,,,Proto-oncogene Mas,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100176,"[""Hormonally up-regulated neu tumor-associated kinase""]",,"A hormonally up-regulated neu tumor-associated kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P57058] |hormonally up-regulated neu tumor-associated kinase (HUNK)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03391034,,,,,,,,"A hormonally up-regulated neu tumor-associated kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P57058] |hormonally up-regulated neu tumor-associated kinase (HUNK)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100176,,,,https://pharos.nih.gov/idg/targets/P57058,,,,,,,,,,,,,HUNK,MAKV,,P57058,,,,,,,,Hormonally up-regulated neu tumor-associated kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2960,"[""photosensitive trichothiodystrophy""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2960,,,,NCI:C4924|OMIM:601675|MESH:D054463|UMLS_CUI:C1955934,sulfur-deficient brittle hair syndrome|Tay syndrome|trichothiodystrophy with congenital ichthyosis|IBIDS syndrome|trichothiodystrophy,,disease_ontology,,DOID:2960,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,photosensitive trichothiodystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200155,"[""KCNJ16 gene""]",,"Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which tends to allow potassium to flow into rather than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels. It may function in fluid and pH balance regulation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_01400427,,,,,,,,"Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which tends to allow potassium to flow into rather than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels. It may function in fluid and pH balance regulation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200155,,,,,,,,,,,,,,,,3773,KCNJ16,,,,,,,,,,,KCNJ16 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400229,"[""SGK495 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400229,,,,,,,,,,,,,,,,,,,,,,,,,,,,SGK495 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000393,"[""THR787 in ERBB3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000393,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR787 in ERBB3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100432,"[""Olfactory receptor 52n4""]",,"An olfactory receptor 52N4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 52N4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100432,,,,https://pharos.nih.gov/idg/targets/Q8NGI2,,,,,,,,,,,,,OR52N4,,,Q8NGI2,,,,,,,,Olfactory receptor 52n4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200689,"[""OR8B8 gene""]",,"An olfactory receptor 8B8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15620] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 8B8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15620] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200689,,,,,,,,,,,,,,,,26493,OR8B8,,,,,,,,,,,OR8B8 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001822,"[""suprachiasmatic nucleus""]",,A small group of neurons situated immediately dorsal to the optic chiasma in the anterior hypothalamus.,false,,,http://purl.obolibrary.org/obo/BTO_0002449|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A small group of neurons situated immediately dorsal to the optic chiasma in the anterior hypothalamus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001822,,,,,,,BrendaTissueOBO,SCN,BTO:0001822,,,,,,,,,,,,,,,,,,,suprachiasmatic nucleus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300142,"[""CK2 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300111,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300142,,,,,,,,,,,,,,,,,,,,,,,,,,,,CK2 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100313,"[""Transmembrane channel-like protein 5""]",,"A transmembrane channel-like protein 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6UXY8] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300372,,,,,,,,"A transmembrane channel-like protein 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6UXY8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100313,,,,https://pharos.nih.gov/idg/targets/Q6UXY8,,,,,,,,,,,,,TMC5,,,Q6UXY8,,,,,,,,Transmembrane channel-like protein 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300108,"[""Atypical group""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300102,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300108,,,,,,,,,,,,,,,,,,,,,,,,,,,,Atypical group,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200051,"[""BUB1B gene""]",,"This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400134,,,,,,,,"This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200051,,,,,,,,,,,,,,,,701,BUB1B,BUBR1|MAD3L|SSK1,,,,,,,,,,BUB1B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000312,"[""THR241 in MP2K5""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000312,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR241 in MP2K5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005351,"[""optic cup""]",,The optic vesicle after invaginating to form a 2-layered cup from which the retina and pigmented layer of the eye will develop.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The optic vesicle after invaginating to form a 2-layered cup from which the retina and pigmented layer of the eye will develop.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005351,XPMUser,2012-03-23T09:36:35Z,,,,,BrendaTissueOBO,ophtalmic cup|eyecup,BTO:0005351,,,,,,,,,,,,,,,,,,,optic cup,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9173,"[""submandibular gland cancer""]",,,false,,,http://purl.obolibrary.org/obo/DOID_12897|http://purl.obolibrary.org/obo/DOID_8850,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9173,,,,SNOMEDCT_US_2016_03_01:94077005|NCI:C3526|ICD9CM:142.1|UMLS_CUI:C0153360|SNOMEDCT_US_2016_03_01:363380002|ICD10CM:C08.0,malignant tumor of the Submandibular gland|malignant neoplasm of submaxillary gland|malignant tumor of submandibular gland (disorder),,disease_ontology,,DOID:9173,,,,,,,,,,,,,,,,,,,submandibular gland cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000119,"[""DYRK2 kinase domain""]",,Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2; DYRK2; FLJ21217; FLJ21365,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2; DYRK2; FLJ21217; FLJ21365,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000119,,,,,,,,,,,,,,,,,,,200121,,,,,,,,,DYRK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000569,"[""exoerythrocytic stage""]",,"The spozoites move to the liver, enter liver cells and replicate asexually through schizogony. This is the exoerythrocytic stage.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000284,,,,,,,,"The spozoites move to the liver, enter liver cells and replicate asexually through schizogony. This is the exoerythrocytic stage.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000569,,,,,,,BrendaTissueOBO,,BTO:0000569,,,,,,,,,,,,,,,,,,,exoerythrocytic stage,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200097,"[""CYBB gene""]",,"Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400346,,,,,,,,"Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200097,,,,,,,,,,,,,,,,1536,CYBB,NOX2,,,,,,,,,,CYBB gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_37550,"[""sphingosine 1-phosphate""]","Sphingosine 1-phosphic acid|
(2S,3R,4E)-1-(dihydrogen phosphate)2-amino-4-Octadecene-1,3-diol
|(2-amino-3-hydroxy-octadec-4-enoxy)phosphonic acid|D-erythro-sphingosine 1-phosphate|DUYSYHSSBDVJSM-KRWOKUGFSA-N|S1P|sphingosine-1-phosphate|CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O|C18H38NO5P|
InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1
|
(2S,3R,4E)-2-amino-4-octadecene-1,3-diol 1-(dihydrogen phosphate)
|Sphing-4-enine 1-phosphate|C18-Sphingosine 1-phosphate|D-Erythro-Sphingosine-1-phosphate|
{[(4E)-2-amino-3-hydroxyoctadec-4-en-1-yl]oxy}phosphonic acid
","
A phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1
",false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,CiteXplore:16046448|CiteXplore:12069819|CiteXplore:18155002|CiteXplore:17308123|CiteXplore:19350109|CiteXplore:15567060|CiteXplore:16913663|CiteXplore:15317688|CiteXplore:15476260|CiteXplore:16956968|CiteXplore:18502612|CiteXplore:12648236|CiteXplore:12778803|CiteXplore:15044318|CiteXplore:19268560|CiteXplore:15326035|CiteXplore:12742827|CiteXplore:16673266|CiteXplore:15143482|CiteXplore:12963813|CiteXplore:14500646|CiteXplore:17098744|CiteXplore:17904858|CiteXplore:15992170|CiteXplore:20671299|CiteXplore:11427538|CiteXplore:17409372|CiteXplore:17374154|CiteXplore:16129068|CiteXplore:19620297|CiteXplore:19293152|CiteXplore:12039947|CiteXplore:15696050|CiteXplore:16148028|CiteXplore:8657285|CiteXplore:15728255|CiteXplore:12730100|CiteXplore:19556602|CiteXplore:12963123|CiteXplore:19815502|LIPID MAPS:LMSP01050001|CiteXplore:15158755|HMDB:HMDB00277|CiteXplore:18387885|CiteXplore:12062172|CiteXplore:11470796|CiteXplore:11278407|CiteXplore:15734735|CiteXplore:10544002|CiteXplore:12069830|KEGG COMPOUND:26993-30-6|CiteXplore:16434032|CiteXplore:17561264|CiteXplore:15258919|KEGG COMPOUND:C06124|Reaxys:5877213|CiteXplore:16162874|CiteXplore:16219683|CiteXplore:17361098|CiteXplore:19662499|CiteXplore:16940153|CiteXplore:17517398|CiteXplore:12401202|CiteXplore:12586615|Beilstein:5877213|CiteXplore:16243846|CiteXplore:9526097|CiteXplore:12069820|Wikipedia:Sphingosine-1-phosphate|CiteXplore:16458188|CiteXplore:11331099|CiteXplore:19081473|CiteXplore:18541717|CiteXplore:11739995|CiteXplore:18787560|CiteXplore:15292266|CiteXplore:11418470|CiteXplore:15761190|CiteXplore:12746430|CiteXplore:19808013|CiteXplore:15778280|CiteXplore:12509810|CiteXplore:17158356|CiteXplore:19423865|CiteXplore:19082500|CiteXplore:18973762|CiteXplore:16322129|Wikipedia:Sphingosine 1-phosphate|CiteXplore:15354862|CiteXplore:12796504|CiteXplore:9668339|CiteXplore:12833634|ChemIDplus:26993-30-6|CiteXplore:14991774|CiteXplore:17220911|CiteXplore:11324700|CiteXplore:19636535|CiteXplore:17391120|CiteXplore:16339142|CiteXplore:16554657,"
A phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:9225|CHEBI:26742,,"Sphingosine 1-phosphate|
(2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate
",,chebi_ontology,"Sphingosine 1-phosphic acid|
(2S,3R,4E)-1-(dihydrogen phosphate)2-amino-4-Octadecene-1,3-diol
|(2-amino-3-hydroxy-octadec-4-enoxy)phosphonic acid|D-erythro-sphingosine 1-phosphate|DUYSYHSSBDVJSM-KRWOKUGFSA-N|S1P|sphingosine-1-phosphate|CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O|C18H38NO5P|
InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1
|
(2S,3R,4E)-2-amino-4-octadecene-1,3-diol 1-(dihydrogen phosphate)
|Sphing-4-enine 1-phosphate|C18-Sphingosine 1-phosphate|D-Erythro-Sphingosine-1-phosphate|
{[(4E)-2-amino-3-hydroxyoctadec-4-en-1-yl]oxy}phosphonic acid
",,,CHEBI:37550,,,,,,,,,,,,,,,,,,,,,,,CHEBI:37550,,,,,sphingosine 1-phosphate|Sphingosine 1-phosphate,,CHEBI:37550,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10141,"[""asthenopia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5614,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10141,,,,UMLS_CUI:C0004095|SNOMEDCT_US_2016_03_01:70323002|ICD10CM:H53.14|MESH:D001248|SNOMEDCT_US_2016_03_01:193645002|SNOMEDCT_US_2016_03_01:46640001,Accommodative strain,,disease_ontology,,DOID:10141,,,,,,,,,,,,,,,,,,,asthenopia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10140,"[""dry eye syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1400,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10140,,,,SNOMEDCT_US_2016_03_01:46152009|ICD10CM:H04.12|NCI:C34553|UMLS_CUI:C0013238|SNOMEDCT_US_2016_03_01:155182003|SNOMEDCT_US_2016_03_01:193980001|MESH:D015352,Tear film insufficiency,,disease_ontology,,DOID:10140,,,,,,,,,,,,,,,,,,,dry eye syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000409,"[""epimastigote""]",,"Any of the bodies representing the morphologic (crithidial) stage in the life cycle of certain trypanosomatid protozoa resembling the typical adult form of members of the genus Crithidia, in which the kinetoplast and basal body are located anterior to the central vesicular nucleus of the slender elongate cell and the flagellum is attached to the body up to the anterior end by a short undulating membrane before becoming free-flowing.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000092,,,,,,,,"Any of the bodies representing the morphologic (crithidial) stage in the life cycle of certain trypanosomatid protozoa resembling the typical adult form of members of the genus Crithidia, in which the kinetoplast and basal body are located anterior to the central vesicular nucleus of the slender elongate cell and the flagellum is attached to the body up to the anterior end by a short undulating membrane before becoming free-flowing.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000409,,,,,,,BrendaTissueOBO,,BTO:0000409,,,,,,,,,,,,,,,,,,,epimastigote,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100600,"[""Creatine kinase U-type, mitochondrial""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100600,,,,,,,,,,,,,,,,,CKMT1A,,,P12532,,,,,,,,"Creatine kinase U-type, mitochondrial",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12506,"[""Bell's palsy""]",,A facial paralysis resulting from dysfunction in the cranial nerve VII (facial nerve).,false,,,http://purl.obolibrary.org/obo/DOID_13934,,,,,,,,A facial paralysis resulting from dysfunction in the cranial nerve VII (facial nerve).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12506,,,,SNOMEDCT_US_2016_03_01:79359001|SNOMEDCT_US_2016_03_01:155070005|ICD9CM:351.0|ICD10CM:G51.0|SNOMEDCT_US_2016_03_01:193093009|MESH:D020330|UMLS_CUI:C0376175|SNOMEDCT_US_2016_03_01:267703001,Bell palsy|Bell's (facial) palsy,,disease_ontology,,DOID:12506,,,,,,,,,,,,,,,,,,,Bell's palsy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200093,"[""CSNK2A3 gene""]",,"This gene encodes a protein that is highly similar to the casein kinase II alpha protein. Casein kinase II is a serine/threonine protein kinase complex that phosphorylates numerous substrates including casein. The alpha subunit is the catalytic component of the complex. Mutations in this gene may be associated with a susceptibility to lung cancer. There are contradictory views among published reports of this gene as to whether or not it is a protein-coding gene or a processed pseudogene (PMIDs: 20625391, 20625391 and 10094393). [provided by RefSeq, Feb 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400142,,,,,,,,"This gene encodes a protein that is highly similar to the casein kinase II alpha protein. Casein kinase II is a serine/threonine protein kinase complex that phosphorylates numerous substrates including casein. The alpha subunit is the catalytic component of the complex. Mutations in this gene may be associated with a susceptibility to lung cancer. There are contradictory views among published reports of this gene as to whether or not it is a protein-coding gene or a processed pseudogene (PMIDs: 20625391, 20625391 and 10094393). [provided by RefSeq, Feb 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200093,,,,,,,,,,,,,,,,283106,CSNK2A3,CSNK2A1P,,,,,,,,,,CSNK2A3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001806,"[""visceral mass""]",,"The visceral mass consists of the gonad, digestive gland, heart, and excretory organs.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001262|http://purl.obolibrary.org/obo/BTO_0001491,,,,,,,,"The visceral mass consists of the gonad, digestive gland, heart, and excretory organs.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001806,,,,,,,BrendaTissueOBO,,BTO:0001806,,,,,,,,,,,,,,,,,,,visceral mass,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200008,"[""TNK2 gene""]",,"This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400118,,,,,,,,"This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200008,,,,,,,,,,,,,,,,10188,TNK2,ACK1,,,,,,,,,,TNK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100368,"[""Nuclear receptor-binding protein""]",,"A nuclear receptor-binding protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UHY1] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300198,,,,,,,,"A nuclear receptor-binding protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UHY1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100368,,,,https://pharos.nih.gov/idg/targets/Q9UHY1,,,,,,,,,,,,,NRBP1,BCON3|NRBP,,Q9UHY1,,,,,,,,Nuclear receptor-binding protein,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200794,"[""TAS2R3 gene""]",,"A taste receptor type 2 member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400014,,,,,,,,"A taste receptor type 2 member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200794,,,,,,,,,,,,,,,,50831,TAS2R3,,,,,,,,,,,TAS2R3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200083,"[""DRD3 gene""]",,"A D(3) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35462] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400037,,,,,,,,"A D(3) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35462] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200083,,,,,,,,,,,,,,,,1814,DRD3,,,,,,,,,,,DRD3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3426,"[""vestibular disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2952,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3426,,,,SNOMEDCT_US_2016_03_01:267761002|SNOMEDCT_US_2016_03_01:194379003|UMLS_CUI:C0042594|ICD10CM:H81.90|ICD10CM:H81.9|SNOMEDCT_US_2016_03_01:20425006|SNOMEDCT_US_2016_03_01:194695008|ICD10CM:H81|MESH:D015837,"Vertigo, vestibular disorder",,disease_ontology,,DOID:3426,,,,,,,,,,,,,,,,,,,vestibular disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000390,"[""THR713 in EPHA8""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000390,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR713 in EPHA8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14464,"[""neuroleptic malignant syndrome""]",,"A nervous system disease that is characterized by hyperthermia, muscular rigidity, autonomic dysfunction and altered consciousness and is associated with administration of antipsychotic and other central dopaminergic blockers.",false,,,http://purl.obolibrary.org/obo/DOID_863,,,,,,,,"A nervous system disease that is characterized by hyperthermia, muscular rigidity, autonomic dysfunction and altered consciousness and is associated with administration of antipsychotic and other central dopaminergic blockers.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14464,,,,ORDO:94093|SNOMEDCT_US_2016_03_01:68977009|SNOMEDCT_US_2016_03_01:192826000|NCI:C94829|ICD9CM:333.92|UMLS_CUI:C0027849|SNOMEDCT_US_2016_03_01:15244003|ICD10CM:G21.0|MESH:D009459,,,disease_ontology,,DOID:14464,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,neuroleptic malignant syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5723,"[""optic atrophy""]",,Xref MGI.,false,,,http://purl.obolibrary.org/obo/DOID_1891,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5723,,,,ICD10CM:H47.2|SNOMEDCT_US_2016_03_01:155188004|ICD9CM:377.1|SNOMEDCT_US_2016_03_01:194042009|ICD10CM:H47.20|ORDO:98673|OMIM:165500|OMIM:311050|NCI:C34863|OMIM:605293|SNOMEDCT_US_2016_03_01:76976005|SNOMEDCT_US_2016_03_01:267742001|UMLS_CUI:C0029124|ICD9CM:377.10|OMIM:165300|OMIM:610708|SNOMEDCT_US_2016_03_01:194046007|OMIM:258500|MESH:D009896,atrophy of optic disc,,disease_ontology,,DOID:5723,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,Xref MGI.,,optic atrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100322,"[""Short transient receptor potential channel 4""]",,"A transient receptor potential cation channel TRPC4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9UBN4] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300579,,,,,,,,"A transient receptor potential cation channel TRPC4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9UBN4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100322,,,,https://pharos.nih.gov/idg/targets/Q9UBN4,,,,,,,,,,,,,TRPC4,,,Q9UBN4,,,,,,,,Short transient receptor potential channel 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003894,"[""skin carcinoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003894,,,,,,,BrendaTissueOBO,,BTO:0003894,,,,,,,,,,,,,,,,,,,skin carcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100029,"[""Atrial natriuretic peptide receptor 2""]",,"An atrial natriuretic peptide receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P20594] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300125,,,,,,,,"An atrial natriuretic peptide receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P20594] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100029,,,,https://pharos.nih.gov/idg/targets/P20594,,,,,,,,,,,,,NPR2,ANPRB,,P20594,,,,,,,,Atrial natriuretic peptide receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001473,"[""blastomere""]",,A cell produced during cleavage of a fertilized egg.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A cell produced during cleavage of a fertilized egg.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001473,,,,,,,BrendaTissueOBO,cleavage cell|segmentation sphere,BTO:0001473,,,,,,,,,,,,,,,,,,,blastomere,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200044,"[""CACNA1G gene""]",,"Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. This gene encodes a T-type, low-voltage activated calcium channel. The T-type channels generate currents that are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing. Many alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400387,,,,,,,,"Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. This gene encodes a T-type, low-voltage activated calcium channel. The T-type channels generate currents that are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing. Many alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200044,,,,,,,,,,,,,,,,8913,CACNA1G,KIAA1123,,,,,,,,,,CACNA1G gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003108,"[""ChaGo-K-1 cell""]",,"Human lung bronchus carcinoma cell line, derived from a bronchogenic carcinoma of a 45-year-old male.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000762,,,,,,,,"Human lung bronchus carcinoma cell line, derived from a bronchogenic carcinoma of a 45-year-old male.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003108,Marion,2014-09-05T10:41:55Z,,,,,BrendaTissueOBO,,BTO:0003108,,,,,,,,,,,,,,,,,,,ChaGo-K-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000182,"[""MET498 in RPS6KA5(Kin.Dom.2-C-terminal)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000182,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET498 in RPS6KA5(Kin.Dom.2-C-terminal),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200538,"[""TRIO gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400168,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200538,,,,,,,,,,,,,,,,7204,TRIO,,,,,,,,,,,TRIO gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200215,"[""KCNK3 gene""]",,"This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400359,,,,,,,,"This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200215,,,,,,,,,,,,,,,,3777,KCNK3,TASK|TASK1,,,,,,,,,,KCNK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001734,"[""gut juice""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000346,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001734,,,,,,,BrendaTissueOBO,,BTO:0001734,,,,,,,,,,,,,,,,,,,gut juice,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300317,"[""MST subfamily>""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300187,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300317,,,,,,,,,,,,,,,,,,,,,,,,,,,,MST subfamily>,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100735,"[""P2y purinoceptor 14""]",,"A P2Y purinoceptor 14 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15391] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300100,,,,,,,,"A P2Y purinoceptor 14 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15391] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100735,,,,https://pharos.nih.gov/idg/targets/Q15391,,,,,,,,,,,,,P2RY14,GPR105|KIAA0001,,Q15391,,,,,,,,P2y purinoceptor 14,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100169,"[""G-protein coupled receptor 183""]",,"A G-protein coupled receptor 183 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32249] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 183 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32249] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100169,,,,https://pharos.nih.gov/idg/targets/P32249,,,,,,,,,,,,,GPR183,EBI2,,P32249,,,,,,,,G-protein coupled receptor 183,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100046,"[""Voltage-dependent t-type calcium channel subunit alpha-1i""]",,"A voltage-dependent T-type calcium channel subunit alpha-1I that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9P0X4] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300389,,,,,,,,"A voltage-dependent T-type calcium channel subunit alpha-1I that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9P0X4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100046,,,,https://pharos.nih.gov/idg/targets/Q9P0X4,,,,,,,,,,,,,CACNA1I,KIAA1120,,Q9P0X4,,,,,,,,Voltage-dependent t-type calcium channel subunit alpha-1i,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1203,"[""drug-induced mental disorder""]",,,false,,,http://purl.obolibrary.org/obo/DOID_8646,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1203,,,,ICD9CM:292.8|UMLS_CUI:C0154325|ICD9CM:292.89,,,disease_ontology,,DOID:1203,,,,,,,,,,,,,,,,,,,drug-induced mental disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12030,"[""panuveitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_13141,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12030,,,,UMLS_CUI:C0030343|ICD10CM:H44.11|NCI:C84989|ICD9CM:360.12|MESH:D015864|SNOMEDCT_US_2016_03_01:75614007,Diffuse uveitis,,disease_ontology,,DOID:12030,,,,,,,,,,,,,,,,,,,panuveitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000552,"[""HaCaT cell""]",,HaCaT is a spontaneously immortalized human keratinocyte cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000375,,,,,,,,HaCaT is a spontaneously immortalized human keratinocyte cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000552,,,,,,,BrendaTissueOBO,,BTO:0000552,,,,,,,,,,,,,,,,,,,HaCaT cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200234,"[""KCNQ3 gene""]",,"This gene encodes a protein that functions in the regulation of neuronal excitability. The encoded protein forms an M-channel by associating with the products of the related KCNQ2 or KCNQ5 genes, which both encode integral membrane proteins. M-channel currents are inhibited by M1 muscarinic acetylcholine receptors and are activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_01400563,,,,,,,,"This gene encodes a protein that functions in the regulation of neuronal excitability. The encoded protein forms an M-channel by associating with the products of the related KCNQ2 or KCNQ5 genes, which both encode integral membrane proteins. M-channel currents are inhibited by M1 muscarinic acetylcholine receptors and are activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200234,,,,,,,,,,,,,,,,3786,KCNQ3,,,,,,,,,,,KCNQ3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200200,"[""AK1 gene""]",,"Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03491001,,,,,,,,"Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200200,,,,,,,,,,,,,,,,203,AK1,,,,,,,,,,,AK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300505,"[""Gamma/CHRNG sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300505,,,,,,,,,,,,,,,,,,,,,,,,,,,,Gamma/CHRNG sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200089,"[""ADGRE1 gene""]",,"An EGF-like module-containing mucin-like hormone receptor-like 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14246] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,"An EGF-like module-containing mucin-like hormone receptor-like 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14246] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200089,,,,,,,,,,,,,,,,2015,EMR1,TM7LN3,,,,,,,,,,ADGRE1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100561,"[""Olfactory receptor 3A1""]",,"An olfactory receptor 3A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47881] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 3A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47881] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100561,,,,https://pharos.nih.gov/idg/targets/P47881,,,,,,,,,,,,,OR3A1,OLFRA03,,P47881,,,,,,,,Olfactory receptor 3A1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100579,"[""UMP-CMP kinase 2, mitochondrial""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100579,,,,,,,,,,,,,,,,,CMPK2,,,Q5EBM0,,,,,,,,"UMP-CMP kinase 2, mitochondrial",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100506,"[""Serine/threonine-protein kinase 3""]",,"serine/threonine-protein kinase 3 (MST2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13188] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300317,,,,,,,,"serine/threonine-protein kinase 3 (MST2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13188] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100506,,,,https://pharos.nih.gov/idg/targets/Q13188,,,,,,,,,,,,,STK3,KRS1|MST2,,Q13188,,,,,,,,Serine/threonine-protein kinase 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200245,"[""LRRC26 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200245,,,,,,,,,,,,,,,,,LRRC26,,,,,,,,,,,LRRC26 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001103,"[""skeletal muscle""]",,"A usually voluntary muscle made up of elongated, multinucleated, transversely striated muscle fibers, having principally bony attachments.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0002385|http://purl.obolibrary.org/obo/BTO_0000887,,,,,,,,"A usually voluntary muscle made up of elongated, multinucleated, transversely striated muscle fibers, having principally bony attachments.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001103,,,,,,,BrendaTissueOBO,striated muscle|somatic muscle|skeletal muscle system,BTO:0001103,,,,,,,,,,,,,,,,,,,skeletal muscle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6888,"[""ureter transitional cell carcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4939|http://purl.obolibrary.org/obo/DOID_2671,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6888,,,,NCI:C4830|SNOMEDCT_US_2016_03_01:300988009|UMLS_CUI:C0577692,ureteral Urothelial cell carcinoma|transitional cell carcinoma of ureter (disorder),,disease_ontology,,DOID:6888,,,,,,,,,,,,,,,,,,,ureter transitional cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300208,"[""NKF2 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300208,,,,,,,,,,,,,,,,,,,,,,,,,,,,NKF2 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100381,"[""Olfactory receptor 4f15""]",,"An olfactory receptor 4F15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4F15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100381,,,,https://pharos.nih.gov/idg/targets/Q8NGB8,,,,,,,,,,,,,OR4F15,,,Q8NGB8,,,,,,,,Olfactory receptor 4f15,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200256,"[""GRIN3B gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400454,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200256,,,,,,,,,,,,,,,,116444,GRIN3B,,,,,,,,,,,GRIN3B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00000014,"[""lipid GPCR ligand""]",,A GPCR ligand that is classified as lipid in CHEBI.,false,,,http://www.drugtargetontology.org/dto/DTO_00000001|http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,,A GPCR ligand that is classified as lipid in CHEBI.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00000014,,,,,,,,,,,,,,,,,,,,,,,,,,,Asiyah Yu Lin,lipid GPCR ligand,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100250,"[""Mas-related g-protein coupled receptor mrg""]",,"A mas-related G-protein coupled receptor MRG that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35410] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300063,,,,,,,,"A mas-related G-protein coupled receptor MRG that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35410] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100250,,,,https://pharos.nih.gov/idg/targets/P35410,,,,,,,,,,,,,MAS1L,MRG,,P35410,,,,,,,,Mas-related g-protein coupled receptor mrg,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000024,"[""Prosaptide""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000024,,,,,,,,,,,,,,,,,,,,,,,,,,,,Prosaptide,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100024,"[""Anoctamin-6""]",,"An anoctamin-6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q4KMQ2] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300329,,,,,,,,"An anoctamin-6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q4KMQ2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100024,,,,https://pharos.nih.gov/idg/targets/Q4KMQ2,,,,,,,,,,,,,ANO6,TMEM16F,,Q4KMQ2,,,,,,,,Anoctamin-6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100166,"[""Heat-stable enterotoxin receptor""]",,"A heat-stable enterotoxin receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P25092] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300125,,,,,,,,"A heat-stable enterotoxin receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P25092] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100166,,,,https://pharos.nih.gov/idg/targets/P25092,,,,,,,,,,,,,GUCY2C,GUC2C|STAR,,P25092,,,,,,,,Heat-stable enterotoxin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100813,"[""Thyrotropin receptor""]",,"A thyrotropin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P16473] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A thyrotropin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P16473] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100813,,,,https://pharos.nih.gov/idg/targets/P16473,,,,,,,,,,,,,TSHR,LGR3,,P16473,,,,,,,,Thyrotropin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060532,"[""latex allergy""]",,A hypersensitivity reaction type I disease triggered by latex.,false,,,http://purl.obolibrary.org/obo/DOID_1205,,,,,,,,A hypersensitivity reaction type I disease triggered by latex.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060532,,,,,,,,,DOID:0060532,,,,,,,,,,,,,,,,,,,latex allergy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000414,"[""SRC kinase domain""]",,Proto-oncogene tyrosine-protein kinase Src; V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); ASV; c-SRC; p60-Src; SRC; SRC1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Proto-oncogene tyrosine-protein kinase Src; V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); ASV; c-SRC; p60-Src; SRC; SRC1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000414,,,,,,,,,,,,,,,,,,,200415,,,,,,,,,SRC kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400256,"[""TAIRE subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400136,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400256,,,,,,,,,,,,,,,,,,,,,,,,,,,,TAIRE subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3225,"[""tracheal disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_974,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3225,,,,MESH:D014133|NCI:C35079|SNOMEDCT_US_2016_03_01:47125007|UMLS_CUI:C0040580|ICD10CM:S12.8,,,disease_ontology,,DOID:3225,,,,,,,,,,,,,,,,,,,tracheal disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000307,"[""THR129 in TESK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000307,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR129 in TESK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2490,"[""congenital nervous system abnormality""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0080015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2490,,,,ICD9CM:742|UMLS_CUI:C0158538|SNOMEDCT_US_2016_03_01:204018008,congenital neurologic anomaly,,disease_ontology,,DOID:2490,,,,,,,,,,,,,,,,,,,congenital nervous system abnormality,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000175,"[""5-oxo-C20:3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000175,,,,,,,,,,,,,,,,,,,,,,,,,,,,5-oxo-C20:3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100557,"[""Serine/threonine-protein kinase ulk3""]",,"A serine/threonine-protein kinase ULK3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6PHR2] |serine/threonine-protein kinase ulk3 (ULK3)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300228,,,,,,,,"A serine/threonine-protein kinase ULK3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6PHR2] |serine/threonine-protein kinase ulk3 (ULK3)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100557,,,,https://pharos.nih.gov/idg/targets/Q6PHR2,,,,,,,,,,,,,ULK3,,,Q6PHR2,,,,,,,,Serine/threonine-protein kinase ulk3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300445,"[""KCNE subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300445,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNE subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000453,"[""fibroblast cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000453,,,,,,,BrendaTissueOBO,FCL,BTO:0000453,,,,,,,,,,,,,,,,,,,fibroblast cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100025,"[""Acid-sensing ion channel 1""]",,"An acid-sensing ion channel 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P78348] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300376,,,,,,,,"An acid-sensing ion channel 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P78348] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100025,,,,https://pharos.nih.gov/idg/targets/P78348,,,,,,,,,,,,,ASIC1,ACCN2|BNAC2,,P78348,,,,,,,,Acid-sensing ion channel 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200331,"[""ZAK gene""]",,"This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400284,,,,,,,,"This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200331,,,,,,,,,,,,,,,,51776,ZAK,MLTK,,,,,,,,,,ZAK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100162,"[""Probable g-protein coupled receptor 162""]",,"A G-protein coupled receptor 162 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q16538] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300052,,,,,,,,"A G-protein coupled receptor 162 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q16538] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100162,,,,https://pharos.nih.gov/idg/targets/Q16538,,,,,,,,,,,,,GPR162,GRCA,,Q16538,,,,,,,,Probable g-protein coupled receptor 162,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_18059,"[""Lipid""]",.,"
'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids.
|'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids.",false,,,http://purl.obolibrary.org/obo/CHEBI_23367,,,,,,,KEGG COMPOUND:C01356|KEGG:C01356,"
'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids.
|'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:6486|CHEBI:25054|CHEBI:14517,,lipids|Lipid|lipid,,chebi_ontology,.,,,CHEBI:18059,,,,,,,,,,,,,,,,,,,,,,,CHEBI:18059,,,,,Lipid|lipid,,CHEBI:18059,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100725,"[""Oxytocin receptor""]",,"An oxytocin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30559] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"An oxytocin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30559] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100725,,,,https://pharos.nih.gov/idg/targets/P30559,,,,,,,,,,,,,OXTR,,,P30559,,,,,,,,Oxytocin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100125,"[""Gamma-aminobutyric acid receptor subunit theta""]",,"A gamma-aminobutyric acid receptor subunit theta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UN88] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300524,,,,,,,,"A gamma-aminobutyric acid receptor subunit theta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UN88] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100125,,,,https://pharos.nih.gov/idg/targets/Q9UN88,,,,,,,,,,,,,GABRQ,,,Q9UN88,,,,,,,,Gamma-aminobutyric acid receptor subunit theta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000421,"[""STK35 kinase domain""]",,Serine/threonine kinase 35; CLIK1; STK35; STK35L1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine kinase 35; CLIK1; STK35; STK35L1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000421,,,,,,,,,,,,,,,,,,,200422,,,,,,,,,STK35 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100190,"[""Probable G-protein coupled receptor 32""]",,"A G-protein coupled receptor 32 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O75388] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 32 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O75388] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100190,,,,https://pharos.nih.gov/idg/targets/O75388,,,,,,,,,,,,,GPR32,,,O75388,,,,,,,,Probable G-protein coupled receptor 32,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491046,"[""PANK2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491028,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491046,,,,,,,,,,,,,,,,,PANK2,,,,,,,,,,,PANK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300344,"[""Calcium release-activated calcium (crac) channel (crac-c) family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300344,,,,,,,,,,,,,,,,,,,,,,,,,,,,Calcium release-activated calcium (crac) channel (crac-c) family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2581,"[""chondrodysplasia punctata""]",,DeObs MGI.,false,,,http://purl.obolibrary.org/obo/DOID_630,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2581,,,,UMLS_CUI:C0008445|NCI:C84632|OMIM:215105|SNOMEDCT_US_2016_03_01:278715001|MESH:D002806|SNOMEDCT_US_2016_03_01:22932004|SNOMEDCT_US_2016_03_01:360507004|SNOMEDCT_US_2016_03_01:42778005|SNOMEDCT_US_2016_03_01:205486004|ICD10CM:Q77.3,Chondrodysplasia punctata congenita (disorder)|Chondrodysplasia calcificans congenita,,disease_ontology,,DOID:2581,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,DeObs MGI.,,chondrodysplasia punctata,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000217,"[""MET90 in TSSK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000217,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET90 in TSSK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491010,"[""Phosphoinositide 3-kinase (PI3K) family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400323,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491010,,,,,,,,,,,,,,,,,,,,,,,,,,,,Phosphoinositide 3-kinase (PI3K) family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200365,"[""OR2AK2 gene""]",,"An olfactory receptor 2AK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG84] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2AK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG84] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200365,,,,,,,,,,,,,,,,391191,OR2AK2,OR2AK1P,,,,,,,,,,OR2AK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100661,"[""Olfactory receptor 6K2""]",,"An olfactory receptor 6K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100661,,,,https://pharos.nih.gov/idg/targets/Q8NGY2,,,,,,,,,,,,,OR6K2,,,Q8NGY2,,,,,,,,Olfactory receptor 6K2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200031,"[""ADRBK1 gene""]",,"The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400250,,,,,,,,"The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200031,,,,,,,,,,,,,,,,156,ADRBK1,BARK|BARK1|GRK2,,,,,,,,,,ADRBK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200340,"[""OR13C2 gene""]",,"An olfactory receptor 13C2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 13C2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200340,,,,,,,,,,,,,,,,392376,OR13C2,,,,,,,,,,,OR13C2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100302,"[""Sodium channel protein type 11 subunit alpha""]",,"A sodium channel protein type 11 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UI33] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300476,,,,,,,,"A sodium channel protein type 11 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UI33] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100302,,,,https://pharos.nih.gov/idg/targets/Q9UI33,,,,,,,,,,,,,SCN11A,SCN12A|SNS2,,Q9UI33,,,,,,,,Sodium channel protein type 11 subunit alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000486,"[""fruit""]",,"The mature ovary or ovaries of a seed-bearing plant, together with accessory parts, containing the seeds and occurring in a wide variety of forms.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The mature ovary or ovaries of a seed-bearing plant, together with accessory parts, containing the seeds and occurring in a wide variety of forms.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000486,,,,,,,BrendaTissueOBO,,BTO:0000486,,,,,,,,,,,,,,,,,,,fruit,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400572,"[""Kv8.1/KCNV1 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400451,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400572,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv8.1/KCNV1 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4186,"[""articulation disorder""]",,"A speech disorder that involves mispronouncing speech sounds by omitting, distorting, substituting, or adding sounds which can make speech difficult to understand.",false,,,http://purl.obolibrary.org/obo/DOID_92,,,,,,,,"A speech disorder that involves mispronouncing speech sounds by omitting, distorting, substituting, or adding sounds which can make speech difficult to understand.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4186,,,,SNOMEDCT_US_2016_03_01:8187005|SNOMEDCT_US_2016_03_01:386701004|MESH:D001184|UMLS_CUI:C0003910,Phonological disorder|Articulation impairment,,disease_ontology,,DOID:4186,,,,,,,,,,,,,,,,,,,articulation disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200152,"[""GPR149 gene""]",,"A G-protein coupled receptor 149 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86SP6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 149 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86SP6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200152,,,,,,,,,,,,,,,,344758,GPR149,PGR10,,,,,,,,,,GPR149 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000146,"[""MET1947 in LRRK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000146,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET1947 in LRRK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100420,"[""Olfactory receptor 52E8""]",,"An olfactory receptor 52E8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IFG1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 52E8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IFG1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100420,,,,https://pharos.nih.gov/idg/targets/Q6IFG1,,,,,,,,,,,,,OR52E8,,,Q6IFG1,,,,,,,,Olfactory receptor 52E8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117512,"[""Estrogen receptor beta""]",,"An estrogen receptor beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92731] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117472,,,,,,,,"An estrogen receptor beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92731] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117512,,,,https://pharos.nih.gov/idg/targets/Q92731,,,,,,,,,,,,,ESR2,NR3A2,,Q92731,,,,,,,,Estrogen receptor beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100144,"[""Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1""]",,"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O60741] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300343,,,,,,,,"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O60741] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100144,,,,https://pharos.nih.gov/idg/targets/O60741,,,,,,,,,,,,,HCN1,BCNG1,,O60741,,,,,,,,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003883,"[""pancreatic ductal adenocarcinoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001521|http://purl.obolibrary.org/obo/BTO_0002363,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003883,,,,,,,BrendaTissueOBO,,BTO:0003883,,,,,,,,,,,,,,,,,,,pancreatic ductal adenocarcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001340,"[""bronchus""]",,Either of the two primary divisions of the trachea that lead respectively into the right and the left lung.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Either of the two primary divisions of the trachea that lead respectively into the right and the left lung.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001340,,,,,,,BrendaTissueOBO,bronchial tissue,BTO:0001340,,,,,,,,,,,,,,,,,,,bronchus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050877,"[""pancreatic agenesis""]",,A pancreas disease that is characterized by the failure of the pancreas to develop prior to birth.,false,,,http://purl.obolibrary.org/obo/DOID_26,,,,,,,,A pancreas disease that is characterized by the failure of the pancreas to develop prior to birth.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050877,lschriml,2014-07-09T03:35:41Z,,OMIM:260370,partial pancreatic agenesis,,disease_ontology,,DOID:0050877,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,pancreatic agenesis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050871,"[""fibroma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060084,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050871,lschriml,2014-06-25T05:14:03Z,,,,,disease_ontology,,DOID:0050871,,,,,,,,,,,,,,,,,,,fibroma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100159,"[""Probable g-protein coupled receptor 158""]",,"A G-protein coupled receptor 158 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5T848] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300004,,,,,,,,"A G-protein coupled receptor 158 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5T848] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100159,,,,https://pharos.nih.gov/idg/targets/Q5T848,,,,,,,,,,,,,GPR158,KIAA1136,,Q5T848,,,,,,,,Probable g-protein coupled receptor 158,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001279,"[""spinal cord""]",,"The cord of nervous tissue that extends from the brain lengthwise along the back in the vertebral canal, gives off the pairs of spinal nerves, carries impulses to and from the brain, and serves as a center for initiating and coordinating many reflex acts.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The cord of nervous tissue that extends from the brain lengthwise along the back in the vertebral canal, gives off the pairs of spinal nerves, carries impulses to and from the brain, and serves as a center for initiating and coordinating many reflex acts.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001279,,,,,,,BrendaTissueOBO,medulla spinalis|spinal medulla,BTO:0001279,,,,,,,,,,,,,,,,,,,spinal cord,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000605,"[""honey""]",,A sweet viscid material elaborated out of the nectar of flowers in the honey sac of various bees.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A sweet viscid material elaborated out of the nectar of flowers in the honey sac of various bees.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000605,,,,,,,BrendaTissueOBO,,BTO:0000605,,,,,,,,,,,,,,,,,,,honey,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200461,"[""OR6C75 gene""]",,"An olfactory receptor 6C75 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NL08] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6C75 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NL08] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200461,,,,,,,,,,,,,,,,390323,OR6C75,,,,,,,,,,,OR6C75 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300411,"[""GRIA2 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300411,,,,,,,,,,,,,,,,,,,,,,,,,,,,GRIA2 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200292,"[""MLK4 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400165,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200292,,,,,,,,,,,,,,,,84451,MLK4,KIAA1804,,,,,,,,,,MLK4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000753,"[""lymphoid tissue""]",,"Tissue that is particularly rich in lymphocytes (and accessory cells such as macrophages and reticular cells), particularly the lymph nodes, spleen, thymus, Peyer's patches, pharyngeal tonsils, adenoids, and (in birds) the Bursa of Fabricius.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Tissue that is particularly rich in lymphocytes (and accessory cells such as macrophages and reticular cells), particularly the lymph nodes, spleen, thymus, Peyer's patches, pharyngeal tonsils, adenoids, and (in birds) the Bursa of Fabricius.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000753,,,,,,,BrendaTissueOBO,lymphoid organ|lymphoid system,BTO:0000753,,,,,,,,,,,,,,,,,,,lymphoid tissue,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00000005,"[""Tclin drug target""]",,Tclin are proteins targeted by approved drugs as they exert their mode of action.,false,,,http://www.w3.org/2002/07/owl#Thing,,,,,,,,Tclin are proteins targeted by approved drugs as they exert their mode of action.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00000005,,,,,,,,,,,,,,,,,,,,,,,,,,"Drug targets are entities with molecular mass present in living systems that, upon interaction with therapeutic agents or their byproducts, result in modified biologic responses that lead to therapeutic outcomes. Here “living systems” encompass humans or animals (e.g., for veterinary medicines) and foreign organisms such as viruses, bacteria or parasites that may be infest humans or animals.
The interaction between a drug and its target results in observable clinical outcomes.
For drug targets, “mode of action” (MoA), referred to as “mechanism of action” when the molecular interactions are well understood, describes the way in which drugs exert their intended therapeutic action, resulting in the intended therapeutic outcome, i.e., the indication(s) stated on the approved drug label, or otherwise the desired outcome (for off-label usage). Some drug-target interactions may lead to unintended clinical outcomes, i.e., side effects or adverse drug reactions. While side effects can be mediated by MoA targets, they are often the result of the interaction between the drug or its metabolites and other proteins.
 (resource: IDG)",IDG; http://www.nature.com/nrd/posters/druggablegenome/nrd_druggablegenome.pdf,Tclin drug target,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200738,"[""F2RL1 gene""]",,"A proteinase-activated receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P55085] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002|http://www.drugtargetontology.org/dto/DTO_02400079,,,,,,,,"A proteinase-activated receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P55085] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200738,,,,,,,,,,,,,,,,2150,F2RL1,GPR11|PAR2,,,,,,,,,,F2RL1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100552,"[""Uridine-cytidine kinase 2""]",,"A uridine-cytidine kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BZX2] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391024,,,,,,,,"A uridine-cytidine kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BZX2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100552,,,,https://pharos.nih.gov/idg/targets/Q9BZX2,,,,,,,,,,,,,UCK2,UMPK,,Q9BZX2,,,,,,,,Uridine-cytidine kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5160,"[""arteriosclerosis obliterans""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2349,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5160,,,,SNOMEDCT_US_2016_03_01:60625000|MESH:D001162|UMLS_CUI:C0003851|SNOMEDCT_US_2016_03_01:361133006,Arteriosclerosis obliterans (disorder) [Ambiguous]|Arteriosclerosis obliterans (disorder),,disease_ontology,,DOID:5160,,,,,,,,,,,,,,,,,,,arteriosclerosis obliterans,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200262,"[""NOX1 gene""]",,"This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400346,,,,,,,,"This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200262,,,,,,,,,,,,,,,,27035,NOX1,MOX1|NOH1,,,,,,,,,,NOX1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100042,"[""Bmp-2-inducible protein kinase""]",,"A BMP-2-inducible protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NSY1] |BMP-2-inducible protein kinase (BIKE)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300115,,,,,,,,"A BMP-2-inducible protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NSY1] |BMP-2-inducible protein kinase (BIKE)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100042,,,,https://pharos.nih.gov/idg/targets/Q9NSY1,,,,,,,,,,,,,BMP2K,BIKE,,Q9NSY1,,,,,,,,Bmp-2-inducible protein kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100350,"[""Olfactory receptor 13J1""]",,"An olfactory receptor 13J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 13J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100350,,,,https://pharos.nih.gov/idg/targets/Q8NGT2,,,,,,,,,,,,,OR13J1,,,Q8NGT2,,,,,,,,Olfactory receptor 13J1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400559,"[""Kv11.3/KCNH7 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400448,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400559,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv11.3/KCNH7 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300072,"[""Neurotensin receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300072,,,,,,,,,,,,,,,,,,,,,,,,,,,,Neurotensin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200193,"[""KCND1 gene""]",,"This gene encodes a multipass membrane protein that comprises the pore subunit of the voltage-gated A-type potassium channel, which functions in the repolarization of membrane action potentials. Activity of voltage-gated potassium channels is important in a number of physiological processes, among them the regulation of neurotransmitter release, heart rate, insulin secretion, and smooth muscle contraction. [provided by RefSeq, Aug 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_01400545,,,,,,,,"This gene encodes a multipass membrane protein that comprises the pore subunit of the voltage-gated A-type potassium channel, which functions in the repolarization of membrane action potentials. Activity of voltage-gated potassium channels is important in a number of physiological processes, among them the regulation of neurotransmitter release, heart rate, insulin secretion, and smooth muscle contraction. [provided by RefSeq, Aug 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200193,,,,,,,,,,,,,,,,3750,KCND1,,,,,,,,,,,KCND1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200123,"[""GABRR2 gene""]",,"GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. The protein encoded by this gene is a member of the rho subunit family and is a component of the GABA receptor complex. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400522,,,,,,,,"GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. The protein encoded by this gene is a member of the rho subunit family and is a component of the GABA receptor complex. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200123,,,,,,,,,,,,,,,,2570,GABRR2,,,,,,,,,,,GABRR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100088,"[""Cyclic nucleotide-gated cation channel alpha-4""]",,"A cyclic nucleotide-gated cation channel alpha-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IV77] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300405,,,,,,,,"A cyclic nucleotide-gated cation channel alpha-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IV77] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100088,,,,https://pharos.nih.gov/idg/targets/Q8IV77,,,,,,,,,,,,,CNGA4,,,Q8IV77,,,,,,,,Cyclic nucleotide-gated cation channel alpha-4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200336,"[""TRPV4 gene""]",,"This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400593,,,,,,,,"This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200336,,,,,,,,,,,,,,,,59341,TRPV4,VRL2|VROAC,,,,,,,,,,TRPV4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200326,"[""MAPK14 gene""]",,"The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400294,,,,,,,,"The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200326,,,,,,,,,,,,,,,,1432,MAPK14,CSBP|CSBP1|CSBP2,,,,,,,,,,MAPK14 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000212,"[""KGP1 kinase domain""]",,"Protein kinase, cGMP-dependent, type I; CGKI; cGKI-alpha; cGKI-BETA; DKFZp686K042; FLJ36117; MGC71944; PGK; PKG; PKG1; PRKG1; PRKG1B; PRKGR1B",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Protein kinase, cGMP-dependent, type I; CGKI; cGKI-alpha; cGKI-BETA; DKFZp686K042; FLJ36117; MGC71944; PGK; PKG; PKG1; PRKG1; PRKG1B; PRKGR1B",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000212,,,,,,,,,,,,,,,,,,,200362,,,,,,,,,KGP1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001577,"[""esophageal cancer cell""]",,Tumor cell or cancer cell of the esophagus.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Tumor cell or cancer cell of the esophagus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001577,,,,,,,BrendaTissueOBO,,BTO:0001577,,,,,,,,,,,,,,,,,,,esophageal cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300594,"[""TRPV5 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300484,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300594,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPV5 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003298,"[""mesenchymal stem cell""]",,"A special adult stem cell, which is a multipotent stem cell, that can be found in bone marrow and can produce all cell types of bone, cartilage, fat, blood, and connective tissues.",false,,,http://purl.obolibrary.org/obo/BTO_0002666|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A special adult stem cell, which is a multipotent stem cell, that can be found in bone marrow and can produce all cell types of bone, cartilage, fat, blood, and connective tissues.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003298,,,,,,,BrendaTissueOBO,mesenchymale Stammzelle|multipotent mesenchymal stromal cell|multipotent stromal cell|MSC cell,BTO:0003298,,,,,,,,,,,,,,,,,,,mesenchymal stem cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100374,"[""Olfactory receptor 2t34""]",,"An olfactory receptor 2T34 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2T34 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100374,,,,https://pharos.nih.gov/idg/targets/Q8NGX1,,,,,,,,,,,,,OR2T34,,,Q8NGX1,,,,,,,,Olfactory receptor 2t34,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200116,"[""GALR2 gene""]",,"A galanin receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O43603] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400046,,,,,,,,"A galanin receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O43603] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200116,,,,,,,,,,,,,,,,8811,GALR2,GALNR2,,,,,,,,,,GALR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001581,"[""embryonic stem cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000669,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001581,,,,,,,BrendaTissueOBO,ES cell line,BTO:0001581,,,,,,,,,,,,,,,,,,,embryonic stem cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000305,"[""crypt""]",,A crypt is a deep pit that protrudes down into the connective tissue surrounding the small intestine. The epithelium at the base of the crypt is the site of stem cell proliferation and the differentiated cells move upwards and are shed 3-5 days later at the tips of the villi.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A crypt is a deep pit that protrudes down into the connective tissue surrounding the small intestine. The epithelium at the base of the crypt is the site of stem cell proliferation and the differentiated cells move upwards and are shed 3-5 days later at the tips of the villi.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000305,,,,,,,BrendaTissueOBO,,BTO:0000305,,,,,,,,,,,,,,,,,,,crypt,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400269,"[""GCN2 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400151,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400269,,,,,,,,,,,,,,,,,,,,,,,,,,,,GCN2 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001487,"[""adipose tissue""]",,Connective tissue in which fat is stored and which has the cells distended by droplets of fat.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000421,,,,,,,,Connective tissue in which fat is stored and which has the cells distended by droplets of fat.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001487,,,BTO:0000441,,,,BrendaTissueOBO,bodyfat|fat tissue|adipose|fat,BTO:0001487,,,,,,,,,,,,,,,,,,,adipose tissue,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_104,"[""bacterial infectious disease""]",,"A disease by infectious agent that results_in infection, has_material_basis_in Bacteria.",false,,,http://purl.obolibrary.org/obo/DOID_0050117,,,,,,,,"A disease by infectious agent that results_in infection, has_material_basis_in Bacteria.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:104,,,,MESH:D016908|MESH:D016905|UMLS_CUI:C0004623|SNOMEDCT_US_2016_03_01:301811001|SNOMEDCT_US_2016_03_01:266182006|SNOMEDCT_US_2016_03_01:186470002|SNOMEDCT_US_2016_03_01:154318005|SNOMEDCT_US_2016_03_01:87628006|NCI:C2890|ICD10CM:A49|SNOMEDCT_US_2016_03_01:266187000|MESH:D001424|ICD10CM:A49.9|SNOMEDCT_US_2016_03_01:187347000,,,disease_ontology,,DOID:104,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,bacterial infectious disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_100,"[""intestinal infectious disease""]",,"An intestinal disease that involves intestinal infection that has material basis in viruses, bacteria, fungi and parasites.",false,,,http://purl.obolibrary.org/obo/DOID_5295,,,,,,,,"An intestinal disease that involves intestinal infection that has material basis in viruses, bacteria, fungi and parasites.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:100,,,DOID:5270|DOID:12509|DOID:10960,SNOMEDCT_US_2016_03_01:266180003|SNOMEDCT_US_2016_03_01:186086003|SNOMEDCT_US_2016_03_01:266071000|ICD10CM:A00-A09|SNOMEDCT_US_2016_03_01:186171006|ICD9CM:001-009.99|SNOMEDCT_US_2016_03_01:127322007|SNOMEDCT_US_2016_03_01:266172005|UMLS_CUI:C0178238|SNOMEDCT_US_2016_03_01:187266003,bacterial enteritis,,disease_ontology,,DOID:100,,,,,,,,,,,,,,,,,Updating outdated UMLS CUI.,,intestinal infectious disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100325,"[""Short transient receptor potential channel 7""]",,"A transient receptor potential cation channel TRPC7 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9HCX4] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300582,,,,,,,,"A transient receptor potential cation channel TRPC7 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9HCX4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100325,,,,https://pharos.nih.gov/idg/targets/Q9HCX4,,,,,,,,,,,,,TRPC7,TRP7,,Q9HCX4,,,,,,,,Short transient receptor potential channel 7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000376,"[""electric organ""]",,A specialized tract of tissue (as in the electric eel) in which electricity is generated.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A specialized tract of tissue (as in the electric eel) in which electricity is generated.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000376,,,,,,,BrendaTissueOBO,,BTO:0000376,,,,,,,,,,,,,,,,,,,electric organ,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10845,"[""St. Louis encephalitis""]",,"A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in St. Louis encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions and has_symptom spastic paralysis.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in St. Louis encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions and has_symptom spastic paralysis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10845,,,,SNOMEDCT_US_2016_03_01:417607009|UMLS_CUI:C0014060|ICD10CM:A83.3|SNOMEDCT_US_2016_03_01:417192005|SNOMEDCT_US_2016_03_01:10429004|ICD9CM:062.3|MESH:D004674,Neuroinvasive St. Louis encephalitis virus infection,,disease_ontology,,DOID:10845,,,,,,,,,,,,,,,,,,,St. Louis encephalitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10843,"[""Western equine encephalitis""]",,"A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Western equine encephalomyelitis virus, which is transmitted_by Culex and transmitted_by Aedes species of mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom anorexia, has_symptom malaise, has_symptom altered mental status, and has_symptom weakness.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Western equine encephalomyelitis virus, which is transmitted_by Culex and transmitted_by Aedes species of mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom anorexia, has_symptom malaise, has_symptom altered mental status, and has_symptom weakness.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10843,,,,ICD9CM:062.1|UMLS_CUI:C0153064|ICD10CM:A83.1|NCI:C85227|SNOMEDCT_US_2016_03_01:47523006|MESH:D020241,,,disease_ontology,WEE,DOID:10843,http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,Western equine encephalitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10842,"[""Murray Valley encephalitis""]",,"A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Murray Valley encephalitis virus, which is transmitted_by Culex annulirostris mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom drowsiness, has_symptom confusion, has_symptom fitting, and has_symptom weakness.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Murray Valley encephalitis virus, which is transmitted_by Culex annulirostris mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom drowsiness, has_symptom confusion, has_symptom fitting, and has_symptom weakness.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10842,,,,ICD9CM:062.4|SNOMEDCT_US_2016_03_01:66454007|ICD10CM:A83.4|UMLS_CUI:C0153066,Australian X disease|Australian encephalitis,,disease_ontology,,DOID:10842,,,,,,,,,,,,,,,,,,,Murray Valley encephalitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000156,"[""FER kinase domain""]",,Fer (fps/fes related) tyrosine kinase; FER; TYK3,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Fer (fps/fes related) tyrosine kinase; FER; TYK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000156,,,,,,,,,,,,,,,,,,,200159,,,,,,,,,FER kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000430,"[""VAL909 in VGFR1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000430,,,,,,,,,,,,,,,,,,,,,,,,,,,,VAL909 in VGFR1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100491,"[""Serine/threonine-protein kinase 32a""]",,"serine/threonine-protein kinase 32a (YANK1)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase 32A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WU08] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300227,,,,,,,,"serine/threonine-protein kinase 32a (YANK1)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase 32A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WU08] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100491,,,,https://pharos.nih.gov/idg/targets/Q8WU08,,,,,,,,,,,,,STK32A,YANK1,,Q8WU08,,,,,,,,Serine/threonine-protein kinase 32a,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5635,"[""gastric adenosquamous carcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5516|http://purl.obolibrary.org/obo/DOID_4830,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5635,,,,NCI:C5474|UMLS_CUI:C1333761,Adenosquamous carcinoma of stomach,,disease_ontology,,DOID:5635,,,,,,,,,,,,,,,,,,,gastric adenosquamous carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491013,"[""Phosphoglycerate kinase family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400324,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491013,,,,,,,,,,,,,,,,,,,,,,,,,,,,Phosphoglycerate kinase family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200517,"[""TBCK gene""]",,"This gene encodes a protein that contains a protein kinase domain, a Rhodanase-like domain and the Tre-2/Bub2/Cdc16 (TBC) domain. The encoded protein is thought to play a role in actin organization, cell growth and cell proliferation by regulating the mammalian target of the rapamycin (mTOR) signaling pathway. This protein may also be involved in the transcriptional regulation of the components of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400232,,,,,,,,"This gene encodes a protein that contains a protein kinase domain, a Rhodanase-like domain and the Tre-2/Bub2/Cdc16 (TBC) domain. The encoded protein is thought to play a role in actin organization, cell growth and cell proliferation by regulating the mammalian target of the rapamycin (mTOR) signaling pathway. This protein may also be involved in the transcriptional regulation of the components of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200517,,,,,,,,,,,,,,,,93627,TBCK,TBCKL,,,,,,,,,,TBCK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100333,"[""Transient receptor potential cation channel subfamily V member 1""]",,"A transient receptor potential cation channel TRPV1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8NER1] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300590,,,,,,,,"A transient receptor potential cation channel TRPV1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8NER1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100333,,,,https://pharos.nih.gov/idg/targets/Q8NER1,,,,,,,,,,,,,TRPV1,VR1,,Q8NER1,,,,,,,,Transient receptor potential cation channel subfamily V member 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000878,"[""mononuclear cell""]",,"A cell having only one nucleus, especially: MONOCYTE.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000574,,,,,,,,"A cell having only one nucleus, especially: MONOCYTE.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000878,,,,,,,BrendaTissueOBO,,BTO:0000878,,,,,,,,,,,,,,,,,,,mononuclear cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1579,"[""respiratory system disease""]",,A disease of anatomical entity that located_in the respiratory system which extends from the nasal sinuses to the diaphragm.,false,,,http://purl.obolibrary.org/obo/DOID_7,,,,,,,,A disease of anatomical entity that located_in the respiratory system which extends from the nasal sinuses to the diaphragm.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1579,,,DOID:3226,SNOMEDCT_US_2016_03_01:266373008|SNOMEDCT_US_2016_03_01:155603009|ICD9CM:510-519.99|SNOMEDCT_US_2016_03_01:196184000|SNOMEDCT_US_2016_03_01:196255004|ICD9CM:519|ICD10CM:J96-J99|UMLS_CUI:C0029582|ICD10CM:J98|SNOMEDCT_US_2016_03_01:196057004,,,disease_ontology,,DOID:1579,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,respiratory system disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200153,"[""KCNJ14 gene""]",,"Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. [provided by RefSeq, Feb 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_01400425,,,,,,,,"Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. [provided by RefSeq, Feb 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200153,,,,,,,,,,,,,,,,3770,KCNJ14,IRK4,,,,,,,,,,KCNJ14 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000108,"[""olfactory epithelium""]",,"Pseudostratified epithelium lining the olfactory region of the nasal cavity, and containing the receptors for the sense of smell.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000912,,,,,,,,"Pseudostratified epithelium lining the olfactory region of the nasal cavity, and containing the receptors for the sense of smell.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000108,,,,,,,BrendaTissueOBO,olfactory sensory epithelium|nasal cavity olfactory epithelium|nasal epithelium|olfactory mucosa,BTO:0000108,,,,,,,,,,,,,,,,,,,olfactory epithelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5719,"[""adrenal medulla cancer""]",,An adrenal gland cancer that is located_in the adrenal medulla.,false,,,http://purl.obolibrary.org/obo/DOID_3953,,,,,,,,An adrenal gland cancer that is located_in the adrenal medulla.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5719,,,DOID:662,UMLS_CUI:C0344456|ICD10CM:C74.1|SNOMEDCT_US_2016_03_01:363480001|SNOMEDCT_US_2016_03_01:127023007|UMLS_CUI:C0596046|NCI:C4856|SNOMEDCT_US_2016_03_01:371965009|SNOMEDCT_US_2016_03_01:93666006|NCI:C4396,malignant tumor of the Adrenal Medulla|adrenal medulla neoplasm|adrenal medulla tumor|malignant neoplasm of adrenal medulla,,disease_ontology,,DOID:5719,,,,,,,,,,,,,,,,,,,adrenal medulla cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001194,"[""rumen""]",,The large first compartment of the stomach of a ruminant in which cellulose is broken down by the action of symbiotic microorganisms.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000480,,,,,,,,The large first compartment of the stomach of a ruminant in which cellulose is broken down by the action of symbiotic microorganisms.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001194,,,,,,,BrendaTissueOBO,paunch,BTO:0001194,,,,,,,,,,,,,,,,,,,rumen,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100222,"[""Metabotropic glutamate receptor 5""]",,"A metabotropic glutamate receptor 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41594] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300059,,,,,,,,"A metabotropic glutamate receptor 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41594] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100222,,,,https://pharos.nih.gov/idg/targets/P41594,,,,,,,,,,,,,GRM5,GPRC1E|MGLUR5,,P41594,,,,,,,,Metabotropic glutamate receptor 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1555,"[""urticaria""]",,"A skin disease characterized by skin rash notable for pale red, raised and itchy bumps, located_in the upper dermis.",false,,,http://purl.obolibrary.org/obo/DOID_37,,,,,,,,"A skin disease characterized by skin rash notable for pale red, raised and itchy bumps, located_in the upper dermis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1555,,,,SNOMEDCT_US_2016_03_01:267817001|UMLS_CUI:C0029839|ICD9CM:708.8|SNOMEDCT_US_2016_03_01:201271001|SNOMEDCT_US_2016_03_01:201267004,,,disease_ontology,,DOID:1555,,,,,,,,,,,,,,,,,,,urticaria,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000075,"[""LEU538 in TLK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000075,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU538 in TLK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100302,"[""Olfactory receptor 10G4""]",,"An olfactory receptor 10G4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10G4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100302,,,,https://pharos.nih.gov/idg/targets/Q8NGN3,,,,,,,,,,,,,OR10G4,,,Q8NGN3,,,,,,,,Olfactory receptor 10G4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001944,"[""H9 cell""]",,Human acute lymphoblastic leukemia cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002144,,,,,,,,Human acute lymphoblastic leukemia cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001944,,,,,,,BrendaTissueOBO,,BTO:0001944,,,,,,,,,,,,,,,,,,,H9 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200373,"[""NTRK3 gene""]",,"This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400200,,,,,,,,"This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200373,,,,,,,,,,,,,,,,4916,NTRK3,TRKC,,,,,,,,,,NTRK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400223,"[""RSKR family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400223,,,,,,,,,,,,,,,,,,,,,,,,,,,,RSKR family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000245,"[""PHE166 in SRPK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000245,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE166 in SRPK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217535,"[""PPARA gene""]",,"Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_00217462,,,,,,,,"Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217535,,,,,,,,,,,,,,,,5465,PPARA,NR1C1|PPAR,,,,,,,,,,PPARA gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001338,"[""synovial tissue""]",,"Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000421,,,,,,,,"Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001338,,,,,,,BrendaTissueOBO,,BTO:0001338,,,,,,,,,,,,,,,,,,,synovial tissue,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200221,"[""GRM4 gene""]",,"A metabotropic glutamate receptor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14833] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400059,,,,,,,,"A metabotropic glutamate receptor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14833] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200221,,,,,,,,,,,,,,,,2914,GRM4,GPRC1D|MGLUR4,,,,,,,,,,GRM4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3973,"[""thyroid medullary carcinoma""]",,A follicular thyroid carcinoma that has_material_basis_in parafollicular cells.,false,,,http://purl.obolibrary.org/obo/DOID_3962,,,,,,,,A follicular thyroid carcinoma that has_material_basis_in parafollicular cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3973,,,,MESH:C536914|SNOMEDCT_US_2016_03_01:32913002|SNOMEDCT_US_2016_03_01:128916007|NCI:C3879|SNOMEDCT_US_2016_03_01:255032005|UMLS_CUI:C0238462,Ultimobranchial thyroid tumour|Medullary carcinoma of the Thyroid gland|medullary thyroid carcinoma|Medullary thyroid carcinoma (disorder)|Ultimobranchial thyroid tumor,,disease_ontology,,DOID:3973,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,thyroid medullary carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100582,"[""Glycerol kinase 3""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100582,,,,,,,,,,,,,,,,,GK3P,,,Q14409,,,,,,,,Glycerol kinase 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200010,"[""HTR5A gene""]",,"A 5-hydroxytryptamine receptor 5A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47898] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402004,,,,,,,,"A 5-hydroxytryptamine receptor 5A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47898] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200010,,,,,,,,,,,,,,,,3361,HTR5A,,,,,,,,,,,HTR5A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200266,"[""P2RX3 gene""]",,"The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400364,,,,,,,,"The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200266,,,,,,,,,,,,,,,,5024,P2RX3,,,,,,,,,,,P2RX3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200622,"[""PRPS1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200622,,,,,,,,,,,,,,,,,,,,,,,,,,,,PRPS1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2237,"[""hepatitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_409,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2237,,,DOID:12352|DOID:1706|DOID:2238|DOID:1707|DOID:14551,ICD10CM:K73.9|SNOMEDCT_US_2016_03_01:155808003|ICD9CM:571.41|SNOMEDCT_US_2016_03_01:197278002|SNOMEDCT_US_2016_03_01:41889008|UMLS_CUI:C0149519|ICD9CM:571.40|SNOMEDCT_US_2016_03_01:197268000|UMLS_CUI:C0001308|NCI:C82978|SNOMEDCT_US_2016_03_01:197288001|SNOMEDCT_US_2016_03_01:155813004|SNOMEDCT_US_2016_03_01:266539002|SNOMEDCT_US_2016_03_01:197289009|SNOMEDCT_US_2016_03_01:266536009|SNOMEDCT_US_2016_03_01:76783007|ICD9CM:570|MESH:D006521|ICD9CM:571.4|UMLS_CUI:C0019189,animal hepatitis|acute and subacute liver necrosis|acute/subac. necrosis of liver|chronic hepatitis|acute hepatitis|chronic persistent hepatitis,,disease_ontology,,DOID:2237,,,,,,,,,,,,,,,,,,,hepatitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100057,"[""T918 in RET(M918T)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100057,,,,,,,,,,,,,,,,,,,,,,,,,,,,T918 in RET(M918T),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300382,"[""CACNA1B subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300333,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300382,,,,,,,,,,,,,,,,,,,,,,,,,,,,CACNA1B subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300400,"[""ClC-6/CLCN6 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300341,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300400,,,,,,,,,,,,,,,,,,,,,,,,,,,,ClC-6/CLCN6 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100490,"[""Serine/threonine-protein kinase 17b""]",,"serine/threonine-protein kinase 17b (DRAK2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase 17B that is encoded in the genome of human. [PRO:DNx, UniProtKB:O94768] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300146,,,,,,,,"serine/threonine-protein kinase 17b (DRAK2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase 17B that is encoded in the genome of human. [PRO:DNx, UniProtKB:O94768] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100490,,,,https://pharos.nih.gov/idg/targets/O94768,,,,,,,,,,,,,STK17B,DRAK2,,O94768,,,,,,,,Serine/threonine-protein kinase 17b,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200584,"[""GK5 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200584,,,,,,,,,,,,,,,,,,,,,,,,,,,,GK5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000344,"[""PIK3CA(E545A) kinase domain""]",,"Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000344,,,,,,,,,,,,,,,,,,,200326,,,,,,,,,PIK3CA(E545A) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300097,"[""C-X-C chemokine receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300031,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300097,,,,,,,,,,,,,,,,,,,,,,,,,,,,C-X-C chemokine receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9478,"[""postpartum depression""]",,"An endogenous depression that involves intense, sustained and sometimes disabling depression experienced by women after giving birth.",false,,,http://purl.obolibrary.org/obo/DOID_1595,,,,,,,,"An endogenous depression that involves intense, sustained and sometimes disabling depression experienced by women after giving birth.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9478,,,,SNOMEDCT_US_2016_03_01:147016002|NCI:C92852|SNOMEDCT_US_2016_03_01:268753005|SNOMEDCT_US_2016_03_01:154889000|SNOMEDCT_US_2016_03_01:58703003|UMLS_CUI:C0221074|SNOMEDCT_US_2016_03_01:191740008|MESH:D019052|SNOMEDCT_US_2016_03_01:192475007|ICD10CM:F53,Maternity blues|postnatal depression,,disease_ontology,,DOID:9478,,,,,,,,,,,,,,,,,,,postpartum depression,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400108,"[""Atypical group gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400102,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400108,,,,,,,,,,,,,,,,,,,,,,,,,,,,Atypical group gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100672,"[""Olfactory receptor 6x1""]",,"An olfactory receptor 6X1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH79] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6X1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH79] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100672,,,,https://pharos.nih.gov/idg/targets/Q8NH79,,,,,,,,,,,,,OR6X1,,,Q8NH79,,,,,,,,Olfactory receptor 6x1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200300,"[""MAPKAPK3 gene""]",,"This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400289,,,,,,,,"This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200300,,,,,,,,,,,,,,,,7867,MAPKAPK3,,,,,,,,,,,MAPKAPK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002477,"[""cecal epithelium""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002477,XPMUser,2011-02-23T10:21:01Z,,,,,BrendaTissueOBO,caecal epithelium,BTO:0002477,,,,,,,,,,,,,,,,,,,cecal epithelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000193,"[""rectal cancer cell""]",,Cancer cell of the rectum.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Cancer cell of the rectum.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000193,,,,,,,BrendaTissueOBO,"carcinoma cell, rectal|rectal carcinoma cell",BTO:0000193,,,,,,,,,,,,,,,,,,,rectal cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100053,"[""T1250 in MET(M1250T)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100053,,,,,,,,,,,,,,,,,,,,,,,,,,,,T1250 in MET(M1250T),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10211,"[""cholelithiasis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060262,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10211,,,,SNOMEDCT_US_2016_03_01:197397004|UMLS_CUI:C0006739|EFO:0004799|SNOMEDCT_US_2016_03_01:266475002|ICD9CM:574.5,,,disease_ontology,,DOID:10211,,,,,,,,,,,,,,,,,,,cholelithiasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11121,"[""pulpitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5330,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11121,,,,NCI:C52595|SNOMEDCT_US_2016_03_01:32620007|SNOMEDCT_US_2016_03_01:155638006|MESH:D011671|UMLS_CUI:C0034103|SNOMEDCT_US_2016_03_01:196331007|ICD9CM:522.0|ICD10CM:K04.0,,,disease_ontology,,DOID:11121,,,,,,,,,,,,,,,,,,,pulpitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200161,"[""KCNJ5 gene""]",,"Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400432,,,,,,,,"Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200161,,,,,,,,,,,,,,,,3762,KCNJ5,GIRK4,,,,,,,,,,KCNJ5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000063,"[""PAF""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000063,,,,,,,,,,,,,,,,,,,,,,,,,,,,PAF,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5648,"[""choroid plexus carcinoma""]",,A choroid plexus cancer that has_material_basis_in epithelial cells of the choroid plexus.,false,,,http://purl.obolibrary.org/obo/DOID_305|http://purl.obolibrary.org/obo/DOID_3540,,,,,,,,A choroid plexus cancer that has_material_basis_in epithelial cells of the choroid plexus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5648,,,DOID:5647,SNOMEDCT_US_2016_03_01:88252006|UMLS_CUI:C0431109|NCI:C4715|NCI:C4533|UMLS_CUI:C0346289|SNOMEDCT_US_2016_03_01:188292007|MESH:C562943,cancer of Choroid Plexus|malignant neoplasm of the Choroid Plexus|malignant neoplasm of choroid plexus|malignant tumor of choroid plexus (disorder)|Choroid plexus carcinoma (morphologic abnormality),,disease_ontology,malignant tumor of choroid plexus,DOID:5648,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,choroid plexus carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001412,"[""U-937 cell""]",,Human histiocytic lymphoma established from the pleural effusion of a 37-year-old man with generalized diffuse histiocytic lymphoma in 1974. Cells were described to express markers and properties of monocytes; Human leukemic monocyte lymphoma cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0000104|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0005583,,,,,,,,Human histiocytic lymphoma established from the pleural effusion of a 37-year-old man with generalized diffuse histiocytic lymphoma in 1974. Cells were described to express markers and properties of monocytes; Human leukemic monocyte lymphoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001412,,,,,,,BrendaTissueOBO,U937 cell,BTO:0001412,,,,,,,,,,,,,,,,,,,U-937 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200615,"[""NMRK2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200615,,,,,,,,,,,,,,,,,,,,,,,,,,,,NMRK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000183,"[""pancreatic cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000183,,,,,,,BrendaTissueOBO,,BTO:0000183,,,,,,,,,,,,,,,,,,,pancreatic cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9255,"[""frontotemporal dementia""]",,A basal ganglia disease characterized by progressive neuronal loss predominantly involving the frontal and/or temporal lobes of the brain resulting in a gradual and progressive decline in behavior or language.,false,,,http://purl.obolibrary.org/obo/DOID_1307|http://purl.obolibrary.org/obo/DOID_679,,,,,,,,A basal ganglia disease characterized by progressive neuronal loss predominantly involving the frontal and/or temporal lobes of the brain resulting in a gradual and progressive decline in behavior or language.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9255,,,,SNOMEDCT_US_2016_03_01:42369001|OMIM:600795|UMLS_CUI:C0520716|MESH:C563003|ORDO:282|OMIM:600274,multiple system tauopathy with presenile dementia|frontotemporal lobar degeneration|pallidopontonigral degeneration|Wilhemsen-Lynch disease,,disease_ontology,,DOID:9255,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,frontotemporal dementia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100243,"[""Protein kinase c gamma type""]",,"A protein kinase C gamma type that is encoded in the genome of human. [PRO:CNA, UniProtKB:P05129] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300276,,,,,,,,"A protein kinase C gamma type that is encoded in the genome of human. [PRO:CNA, UniProtKB:P05129] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100243,,,,https://pharos.nih.gov/idg/targets/P05129,,,,,,,,,,,,,PRKCG,PKCG,,P05129,,,,,,,,Protein kinase c gamma type,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100276,"[""Neuropeptides B/W receptor type 1""]",,"A neuropeptides B/W receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48145] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300068,,,,,,,,"A neuropeptides B/W receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48145] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100276,,,,https://pharos.nih.gov/idg/targets/P48145,,,,,,,,,,,,,NPBWR1,GPR7,,P48145,,,,,,,,Neuropeptides B/W receptor type 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300509,"[""GABRA4 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300509,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRA4 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300458,"[""NR2D/GRIN2D subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300458,,,,,,,,,,,,,,,,,,,,,,,,,,,,NR2D/GRIN2D subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200260,"[""GRIN2D gene""]",,"N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400458,,,,,,,,"N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200260,,,,,,,,,,,,,,,,2906,GRIN2D,GluN2D|NMDAR2D,,,,,,,,,,GRIN2D gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002729,"[""ovarian serous carcinoma cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001023,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002729,,,,,,,BrendaTissueOBO,OSC cell,BTO:0002729,,,,,,,,,,,,,,,,,,,ovarian serous carcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100776,"[""Taste receptor type 2 member 10""]",,"A taste receptor type 2 member 10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300014,,,,,,,,"A taste receptor type 2 member 10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100776,,,,https://pharos.nih.gov/idg/targets/Q9NYW0,,,,,,,,,,,,,TAS2R10,,,Q9NYW0,,,,,,,,Taste receptor type 2 member 10,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300533,"[""Kv1.2/KCNA2 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300436,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300533,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv1.2/KCNA2 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12185,"[""otosclerosis""]",,An otitis interna characterized by an abnormal bone growth in the middle ear.,false,,,http://purl.obolibrary.org/obo/DOID_2952,,,,,,,,An otitis interna characterized by an abnormal bone growth in the middle ear.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12185,,,,OMIM:608484|OMIM:612096|OMIM:615589|ORDO:2794|OMIM:611572|OMIM:605727|ICD10CM:H80.8|ICD10CM:H80.80|UMLS_CUI:C0029696|SNOMEDCT_US_2016_03_01:194382008|ICD9CM:387.8|SNOMEDCT_US_2016_03_01:194691004|EFO:0004213|OMIM:608244|OMIM:166800|OMIM:611571,,,disease_ontology,,DOID:12185,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,otosclerosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100171,"[""Voltage-gated potassium channel subunit beta-3""]",,"A voltage-gated potassium channel subunit beta-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43448] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300356,,,,,,,,"A voltage-gated potassium channel subunit beta-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43448] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100171,,,,https://pharos.nih.gov/idg/targets/O43448,,,,,,,,,,,,,KCNAB3,KCNA3B,,O43448,,,,,,,,Voltage-gated potassium channel subunit beta-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001882,"[""ovary adenocarcinoma cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0000167|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000811,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001882,,,,,,,BrendaTissueOBO,ovarian adenocarcinoma cell line,BTO:0001882,,,,,,,,,,,,,,,,,,,ovary adenocarcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100460,"[""Olfactory receptor 6C74""]",,"An olfactory receptor 6C74 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NCV1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6C74 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NCV1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100460,,,,https://pharos.nih.gov/idg/targets/A6NCV1,,,,,,,,,,,,,OR6C74,,,A6NCV1,,,,,,,,Olfactory receptor 6C74,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200565,"[""WEE1 gene""]",,"This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400212,,,,,,,,"This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200565,,,,,,,,,,,,,,,,7465,WEE1,,,,,,,,,,,WEE1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9091,"[""REM sleep behavior disorder""]",,A sleep disorder that involves abnormal behavior including the acting out of violent or dramatic dreams during the sleep phase with rapid eye movement.,false,,,http://purl.obolibrary.org/obo/DOID_535,,,,,,,,A sleep disorder that involves abnormal behavior including the acting out of violent or dramatic dreams during the sleep phase with rapid eye movement.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9091,,,,MESH:D020187|UMLS_CUI:C0751772|ICD9CM:327.42|SNOMEDCT_US_2016_03_01:415238003|ICD10CM:G47.52,Rapid eye movement sleep behavior disorder ,,disease_ontology,,DOID:9091,,,,,,,,,,,,,,,,,,,REM sleep behavior disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200475,"[""OPN1LW gene""]",,"A long-wave-sensitive opsin 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P04000] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A long-wave-sensitive opsin 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P04000] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200475,,,,,,,,,,,,,,,,5956,OPN1LW,RCP,,,,,,,,,,OPN1LW gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100508,"[""Olfactory receptor 2A1/2A42""]",,An olfactory receptor 2A1/2A42 that is encoded in the genome of human. ,false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,An olfactory receptor 2A1/2A42 that is encoded in the genome of human. ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100508,,,,https://pharos.nih.gov/idg/targets/Q8NGT9,,,,,,,,,,,,,OR2A1,OR2A42,,Q8NGT9,,,,,,,,Olfactory receptor 2A1/2A42,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100239,"[""Lysophosphatidic acid receptor 2""]",,"A lysophosphatidic acid receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HBW0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302007,,,,,,,,"A lysophosphatidic acid receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HBW0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100239,,,,https://pharos.nih.gov/idg/targets/Q9HBW0,,,,,,,,,,,,,LPAR2,EDG4|LPA2,,Q9HBW0,,,,,,,,Lysophosphatidic acid receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100040,"[""P396 in ABL1(H396P)-nonphosphorylated""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100040,,,,,,,,,,,,,,,,,,,,,,,,,,,,P396 in ABL1(H396P)-nonphosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200330,"[""MLKL gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400192,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200330,,,,,,,,,,,,,,,,197259,MLKL,,,,,,,,,,,MLKL gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000346,"[""THR333 in HCK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000346,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR333 in HCK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6270,"[""gastric cardia carcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_10548|http://purl.obolibrary.org/obo/DOID_5517,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6270,,,,NCI:C6794|UMLS_CUI:C1333763,carcinoma of Cardia of stomach,,disease_ontology,,DOID:6270,,,,,,,,,,,,,,,,,,,gastric cardia carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003898,"[""GT1 cell""]",,GT1 cells belong to an immortalized line of mouse hypothalamic GnRH secreting neurons that exhibit a pulsatile secretion of GnRH.,false,,,http://purl.obolibrary.org/obo/BTO_0000947|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,GT1 cells belong to an immortalized line of mouse hypothalamic GnRH secreting neurons that exhibit a pulsatile secretion of GnRH.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003898,,,,,,,BrendaTissueOBO,,BTO:0003898,,,,,,,,,,,,,,,,,,,GT1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300046,"[""Galanin receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300046,,,,,,,,,,,,,,,,,,,,,,,,,,,,Galanin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_341,"[""peripheral vascular disease""]",,"A vascular disease that is characterized by obstruction of larger arteries not within the coronary, aortic arch vasculature, or brain.",false,,,http://purl.obolibrary.org/obo/DOID_178,,,,,,,,"A vascular disease that is characterized by obstruction of larger arteries not within the coronary, aortic arch vasculature, or brain.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:341,,,DOID:2868,MESH:D016481|UMLS_CUI:C0031115|SNOMEDCT_US_2016_03_01:195624006|UMLS_CUI:C0003838|MESH:D001157|ICD9CM:443.81|SNOMEDCT_US_2016_03_01:2929001,arterial occlusive disease,,disease_ontology,,DOID:341,,,,,,,,,,,,,,,,,,,peripheral vascular disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_342,"[""subclavian artery aneurysm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0050828,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:342,,,,ICD9CM:442.82|UMLS_CUI:C0155746|SNOMEDCT_US_2016_03_01:40136003,,,disease_ontology,,DOID:342,,,,,,,,,,,,,,,,,,,subclavian artery aneurysm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_345,"[""uterine disease""]",,A female reproductive system disease that is located_in the uterus.,false,,,http://purl.obolibrary.org/obo/DOID_229,,,,,,,,A female reproductive system disease that is located_in the uterus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:345,,,,ICD9CM:621.9|SNOMEDCT_US_2016_03_01:156004005|SNOMEDCT_US_2016_03_01:156009000|MESH:D014591|UMLS_CUI:C0042131|SNOMEDCT_US_2016_03_01:12337004|SNOMEDCT_US_2016_03_01:237068005|ICD10CM:N85.9|SNOMEDCT_US_2016_03_01:198335006|NCI:C26907,,,disease_ontology,,DOID:345,,,,,,,,,,,,,,,,,,,uterine disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100092,"[""Putative adhesion G protein-coupled receptor E4P""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100092,,,,https://pharos.nih.gov/idg/targets/Q86SQ3,,,,,,,,,,,,,EMR4P,ADGRE4P|EMR4|GPR127|PGR16,,Q86SQ3,,,,,,,,Putative adhesion G protein-coupled receptor E4P,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100223,"[""Metabotropic glutamate receptor 6""]",,"A metabotropic glutamate receptor 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15303] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300059,,,,,,,,"A metabotropic glutamate receptor 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15303] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100223,,,,https://pharos.nih.gov/idg/targets/O15303,,,,,,,,,,,,,GRM6,GPRC1F|MGLUR6,,O15303,,,,,,,,Metabotropic glutamate receptor 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000778,"[""pulmonary artery""]",,An artery that conveys venous blood from the heart to the lungs.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000573,,,,,,,,An artery that conveys venous blood from the heart to the lungs.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000778,,,,,,,BrendaTissueOBO,,BTO:0000778,,,,,,,,,,,,,,,,,,,pulmonary artery,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100031,"[""Bestrophin-2""]",,"A bestrophin-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFU1] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300331,,,,,,,,"A bestrophin-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFU1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100031,,,,https://pharos.nih.gov/idg/targets/Q8NFU1,,,,,,,,,,,,,BEST2,VMD2L1,,Q8NFU1,,,,,,,,Bestrophin-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100637,"[""Olfactory receptor 5m3""]",,"An olfactory receptor 5M3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5M3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100637,,,,https://pharos.nih.gov/idg/targets/Q8NGP4,,,,,,,,,,,,,OR5M3,,,Q8NGP4,,,,,,,,Olfactory receptor 5m3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200221,"[""CAMK2G gene""]",,"The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.[provided by RefSeq, Mar 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400172,,,,,,,,"The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.[provided by RefSeq, Mar 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200221,,,,,,,,,,,,,,,,818,CAMK2G,CAMK|CAMK-II|CAMKG,,,,,,,,,,CAMK2G gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2671,"[""transitional cell carcinoma""]",,A carcinoma that derives_from transitional epithelial cells.,false,,,http://purl.obolibrary.org/obo/DOID_305,,,,,,,,A carcinoma that derives_from transitional epithelial cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2671,,,DOID:3995,NCI:C2930|SNOMEDCT_US_2016_03_01:118287003|UMLS_CUI:C0334265|NCI:C6783|UMLS_CUI:C0007138|SNOMEDCT_US_2016_03_01:27090000|SNOMEDCT_US_2016_03_01:189576006|MESH:D002295,urothelial cell carcinoma |transitional carcinoma|transitional cell tumor,,disease_ontology,transitional cell neoplasm,DOID:2671,,,,,,,,,,,,,,,,,,,transitional cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100067,"[""Cyclin-dependent kinase 20""]",,"A cyclin-dependent kinase 20 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZL9] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300259,,,,,,,,"A cyclin-dependent kinase 20 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZL9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100067,,,,https://pharos.nih.gov/idg/targets/Q8IZL9,,,,,,,,,,,,,CDK20,CCRK|CDCH,,Q8IZL9,,,,,,,,Cyclin-dependent kinase 20,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200032,"[""BEST3 gene""]",,"BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]).[supplied by OMIM, Mar 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400331,,,,,,,,"BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]).[supplied by OMIM, Mar 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200032,,,,,,,,,,,,,,,,144453,BEST3,VMD2L3,,,,,,,,,,BEST3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004012,"[""ROS cell""]",,Rat osteosarcoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000407,,,,,,,,Rat osteosarcoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004012,,,,,,,BrendaTissueOBO,,BTO:0004012,,,,,,,,,,,,,,,,,,,ROS cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100265,"[""Serine/threonine-protein kinase lats2""]",,"serine/threonine-protein kinase lats2 (LATS2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase LATS2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NRM7] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300181,,,,,,,,"serine/threonine-protein kinase lats2 (LATS2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase LATS2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NRM7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100265,,,,https://pharos.nih.gov/idg/targets/Q9NRM7,,,,,,,,,,,,,LATS2,KPM,,Q9NRM7,,,,,,,,Serine/threonine-protein kinase lats2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100482,"[""Sphingosine kinase 1""]",,"A sphingosine kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYA1] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300323,,,,,,,,"A sphingosine kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYA1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100482,,,,https://pharos.nih.gov/idg/targets/Q9NYA1,,,,,,,,,,,,,SPHK1,SPHK|SPK,,Q9NYA1,,,,,,,,Sphingosine kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200341,"[""CDC42BPA gene""]",,"The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400265,,,,,,,,"The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200341,,,,,,,,,,,,,,,,8476,CDC42BPA,KIAA0451,,,,,,,,,,CDC42BPA gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100496,"[""Olfactory receptor 1L1""]",,"An olfactory receptor 1L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH94] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH94] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100496,,,,https://pharos.nih.gov/idg/targets/Q8NH94,,,,,,,,,,,,,OR1L1,OR1L2,,Q8NH94,,,,,,,,Olfactory receptor 1L1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300552,"[""Kv6.4/KCNG4 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300447,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300552,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv6.4/KCNG4 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5822,"[""gray zone lymphoma""]",,A lymphoma that is characterized by having cellular features of both classic Hodgkin's lymphomas and large B-cell Lymphomas.,false,,,http://purl.obolibrary.org/obo/DOID_0060058,,,,,,,,A lymphoma that is characterized by having cellular features of both classic Hodgkin's lymphomas and large B-cell Lymphomas.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5822,,,,UMLS_CUI:C1333878|NCI:C37869,,,disease_ontology,,DOID:5822,,,,,,,,,,,,,,,,,,,gray zone lymphoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14270,"[""ascending cholangitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_9446,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14270,,,,SNOMEDCT_US_2016_03_01:26918003|NCI:C35372|ICD10CM:K83.0|UMLS_CUI:C0311273,Ascending Cholangitis|Ascending cholangitis (disorder),,disease_ontology,,DOID:14270,,,,,,,,,,,,,,,,,,,ascending cholangitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400422,"[""KCNJ11 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400422,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ11 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300068,"[""Neuropeptide W/neuropeptide B receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300068,,,,,,,,,,,,,,,,,,,,,,,,,,,,Neuropeptide W/neuropeptide B receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001104,"[""cranial nerve""]",,"Any of several nerves that arise in pairs from the brainstem and reach the periphery through openings in the skull. There are 12 such pairs in mammals, birds, and reptiles and usually 10 pairs in amphibians and fish.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000925,,,,,,,,"Any of several nerves that arise in pairs from the brainstem and reach the periphery through openings in the skull. There are 12 such pairs in mammals, birds, and reptiles and usually 10 pairs in amphibians and fish.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001104,,,,,,,BrendaTissueOBO,,BTO:0001104,,,,,,,,,,,,,,,,,,,cranial nerve,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000214,"[""MET90 in CSNK1A1L""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000214,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET90 in CSNK1A1L,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200521,"[""OR2D3 gene""]",,"An olfactory receptor 2D3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2D3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200521,,,,,,,,,,,,,,,,120775,OR2D3,,,,,,,,,,,OR2D3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217461,"[""Retinoic acid receptors gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00200002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217461,,,,,,,,,,,,,,,,,,,,,,,,,,,,Retinoic acid receptors gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003671,"[""germinal center""]",,The area in the center of a lymph node containing aggregations of actively proliferating lymphocytes.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The area in the center of a lymph node containing aggregations of actively proliferating lymphocytes.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003671,,,,,,,BrendaTissueOBO,,BTO:0003671,,,,,,,,,,,,,,,,,,,germinal center,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00400202,"[""Tbio""]",,"These targets do not have known drug or small molecule activities that satisfy the activity thresholds detailed below AND satisfy one or more of the following criteria: (1)target is above the cutoff criteria for Tdark, (2)target is annotated with a Gene Ontology Molecular Function or Biological Process leaf term(s) with an Experimental Evidence code, (3)target has confirmed OMIM phenotype(s) (source: http://juniper.health.unm.edu/tcrd/)",false,,,http://www.drugtargetontology.org/dto/DTO_00400001,,,,,,,,"These targets do not have known drug or small molecule activities that satisfy the activity thresholds detailed below AND satisfy one or more of the following criteria: (1)target is above the cutoff criteria for Tdark, (2)target is annotated with a Gene Ontology Molecular Function or Biological Process leaf term(s) with an Experimental Evidence code, (3)target has confirmed OMIM phenotype(s) (source: http://juniper.health.unm.edu/tcrd/)",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00400202,,,,,,,,,,,,,,,,,,,,,,,,,,,,Tbio,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200135,"[""GPR116 gene""]",,"A G-protein coupled receptor 116 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,"A G-protein coupled receptor 116 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200135,,,,,,,,,,,,,,,,221395,GPR116,KIAA0758,,,,,,,,,,GPR116 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100438,"[""Camp-dependent protein kinase catalytic subunit prkx""]",,"camp-dependent protein kinase catalytic subunit prkx (PRKX)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase PRKX that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51817] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300169,,,,,,,,"camp-dependent protein kinase catalytic subunit prkx (PRKX)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase PRKX that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51817] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100438,,,,https://pharos.nih.gov/idg/targets/P51817,,,,,,,,,,,,,PRKX,PKX1,,P51817,,,,,,,,Camp-dependent protein kinase catalytic subunit prkx,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300059,"[""Metabotropic glutamate receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300004,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300059,,,,,,,,,,,,,,,,,,,,,,,,,,,,Metabotropic glutamate receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300125,"[""RGC family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300110,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300125,,,,,,,,,,,,,,,,,,,,,,,,,,,,RGC family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100747,"[""Prostaglandin F2-alpha receptor""]",,"A prostaglandin F2-alpha receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43088] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A prostaglandin F2-alpha receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43088] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100747,,,,https://pharos.nih.gov/idg/targets/P43088,,,,,,,,,,,,,PTGFR,,,P43088,,,,,,,,Prostaglandin F2-alpha receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200195,"[""KCND3 gene""]",,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400547,,,,,,,,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200195,,,,,,,,,,,,,,,,3752,KCND3,,,,,,,,,,,KCND3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200109,"[""FZD7 gene""]",,"A frizzled-7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75084] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400043,,,,,,,,"A frizzled-7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75084] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200109,,,,,,,,,,,,,,,,8324,FZD7,,,,,,,,,,,FZD7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200583,"[""OR4D11 gene""]",,"An olfactory receptor 4D11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4D11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200583,,,,,,,,,,,,,,,,219986,OR4D11,OR4D11P,,,,,,,,,,OR4D11 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300274,"[""ILK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300165,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300274,,,,,,,,,,,,,,,,,,,,,,,,,,,,ILK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100178,"[""Calcium-activated potassium channel subunit beta-3""]",,"A calcium-activated potassium channel subunit beta-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NPA1] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300440,,,,,,,,"A calcium-activated potassium channel subunit beta-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NPA1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100178,,,,https://pharos.nih.gov/idg/targets/Q9NPA1,,,,,,,,,,,,,KCNMB3,KCNMB2|KCNMBL,,Q9NPA1,,,,,,,,Calcium-activated potassium channel subunit beta-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14484,"[""sporotrichosis""]",,"A primary systemic mycosis that results_in a systemic fungal infection, has_material_basis_in Sporothrix schenckii in animals and humans and results_in_formation_of red papule at the site of inoculation.",false,,,http://purl.obolibrary.org/obo/DOID_0050292,,,,,,,,"A primary systemic mycosis that results_in a systemic fungal infection, has_material_basis_in Sporothrix schenckii in animals and humans and results_in_formation_of red papule at the site of inoculation.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14484,,,,MESH:D013174|SNOMEDCT_US_2016_03_01:154408001|SNOMEDCT_US_2016_03_01:187488001|ICD9CM:117.1|SNOMEDCT_US_2016_03_01:187078008|UMLS_CUI:C0038034|SNOMEDCT_US_2016_03_01:266218008|ICD10CM:B42|ICD10CM:B42.9|SNOMEDCT_US_2016_03_01:42094007,,,disease_ontology,,DOID:14484,,,,,,,,,,,,,,,,,,,sporotrichosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200485,"[""SRMS gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400132,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200485,,,,,,,,,,,,,,,,6725,SRMS,C20orf148,,,,,,,,,,SRMS gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000501,"[""gastric juice""]",,A thin watery acid digestive fluid secreted by glands in the mucous membrane of the stomach.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000346,,,,,,,,A thin watery acid digestive fluid secreted by glands in the mucous membrane of the stomach.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000501,,,,,,,BrendaTissueOBO,succus gastricus,BTO:0000501,,,,,,,,,,,,,,,,,,,gastric juice,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200195,"[""GPR39 gene""]",,"A G-protein coupled receptor 39 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O43194] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 39 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O43194] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200195,,,,,,,,,,,,,,,,2863,GPR39,,,,,,,,,,,GPR39 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400473,"[""Nav1.6/SCN8A subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400369,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400473,,,,,,,,,,,,,,,,,,,,,,,,,,,,Nav1.6/SCN8A subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200277,"[""PKD1L3 gene""]",,"This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores.[provided by RefSeq, Apr 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400367,,,,,,,,"This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores.[provided by RefSeq, Apr 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200277,,,,,,,,,,,,,,,,342372,PKD1L3,,,,,,,,,,,PKD1L3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217566,"[""AR gene""]",,"The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_00217474,,,,,,,,"The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217566,,,,,,,,,,,,,,,,367,AR,DHTR|NR3C4,,,,,,,,,,AR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050615,"[""respiratory system cancer""]",,An organ system cancer located_in the respiratory system that is characterized by uncontrolled cellular proliferation in the respiratory tract.,false,,,http://purl.obolibrary.org/obo/DOID_0050686|http://purl.obolibrary.org/obo/DOID_1579,,,,,,,,An organ system cancer located_in the respiratory system that is characterized by uncontrolled cellular proliferation in the respiratory tract.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050615,,,,,,,disease_ontology,,DOID:0050615,,,,,,,,,,,,,,,,,,,respiratory system cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050619,"[""paranasal sinus cancer""]",,A respiratory system cancer that is located_in the paranasal sinuses.,false,,,http://purl.obolibrary.org/obo/DOID_1352|http://purl.obolibrary.org/obo/DOID_0050615|http://purl.obolibrary.org/obo/DOID_299,,,,,,,,A respiratory system cancer that is located_in the paranasal sinuses.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050619,,,DOID:2442|DOID:1354|DOID:2767|DOID:4689|DOID:2765,UMLS_CUI:C1335337|NCI:C8193|UMLS_CUI:C0854995|UMLS_CUI:C1335340|UMLS_CUI:C1335336|MESH:D010255|NCI:C6018|NCI:C6014|UMLS_CUI:C0280334|NCI:C6017|NCI:C6019,paranasal sinus mucoepidermoid carcinoma|Mucoepidermoid carcinoma of Accessory sinus|paranasal sinus adenocarcinoma|paranasal sinus adenoid cystic carcinoma|paranasal sinus squamous cell carcinoma|adenoid cystic carcinoma of Accessory sinus|Epidermoid carcinoma of the paranasal sinus,,disease_ontology,squamous cell carcinoma of paranasal sinus|adenoid cystic carcinoma of paranasal sinus,DOID:0050619,,,,,,,,,,,,,,,,,,,paranasal sinus cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400351,"[""Glutamate-gated ion channel  (GIC) Family of Neurotransmitter Receptors gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400351,,,,,,,,,,,,,,,,,,,,,,,,,,,,Glutamate-gated ion channel  (GIC) Family of Neurotransmitter Receptors gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300480,"[""SCNN1G subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300330,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300480,,,,,,,,,,,,,,,,,,,,,,,,,,,,SCNN1G subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4757,"[""sex cord-stromal neoplasm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060087|http://purl.obolibrary.org/obo/DOID_192|http://purl.obolibrary.org/obo/DOID_2998,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4757,,,,NCI:C6358|SNOMEDCT_US_2016_03_01:702406000|UMLS_CUI:C3840076,Sex Cord-Stromal tumor of testis,,disease_ontology,,DOID:4757,,,,,,,,,,,,,,,,,,,sex cord-stromal neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100022,"[""Anoctamin-1""]",,"An anoctamin-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5XXA6] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300329,,,,,,,,"An anoctamin-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5XXA6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100022,,,,https://pharos.nih.gov/idg/targets/Q5XXA6,,,,,,,,,,,,,ANO1,DOG1|ORAOV2|TAOS2|TMEM16A,,Q5XXA6,,,,,,,,Anoctamin-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200190,"[""IRAK1 gene""]",,"This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400166,,,,,,,,"This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200190,,,,,,,,,,,,,,,,3654,IRAK1,IRAK,,,,,,,,,,IRAK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100027,"[""Ankyrin repeat and protein kinase domain-containing protein 1""]",,"An ankyrin repeat and protein kinase domain-containing protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFD2] |ankyrin repeat and protein kinase domain-containing protein 1 (ANKK1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300124,,,,,,,,"An ankyrin repeat and protein kinase domain-containing protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFD2] |ankyrin repeat and protein kinase domain-containing protein 1 (ANKK1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100027,,,,https://pharos.nih.gov/idg/targets/Q8NFD2,,,,,,,,,,,,,ANKK1,PKK2|SGK288,,Q8NFD2,,,,,,,,Ankyrin repeat and protein kinase domain-containing protein 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400084,"[""Parathyroid hormone receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400003,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400084,,,,,,,,,,,,,,,,,,,,,,,,,,,,Parathyroid hormone receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100185,"[""Probable g-protein coupled receptor 22""]",,"A G-protein coupled receptor 22 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99680] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300053,,,,,,,,"A G-protein coupled receptor 22 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99680] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100185,,,,https://pharos.nih.gov/idg/targets/Q99680,,,,,,,,,,,,,GPR22,,,Q99680,,,,,,,,Probable g-protein coupled receptor 22,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3305,"[""teratocarcinoma""]",,"A mixed germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or with both.",false,,,http://purl.obolibrary.org/obo/DOID_3095|http://purl.obolibrary.org/obo/DOID_3306,,,,,,,,"A mixed germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or with both.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3305,,,,NCI:C3756|MESH:D018243|SNOMEDCT_US_2016_03_01:67830002|UMLS_CUI:C0206664,mixed Embryonal carcinoma and teratoma|Teratocarcinoma (morphologic abnormality),,disease_ontology,,DOID:3305,,,,,,,,,,,,,,,,,,,teratocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100226,"[""Gastrin-releasing peptide receptor""]",,"A gastrin-releasing peptide receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30550] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300026,,,,,,,,"A gastrin-releasing peptide receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30550] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100226,,,,https://pharos.nih.gov/idg/targets/P30550,,,,,,,,,,,,,GRPR,,,P30550,,,,,,,,Gastrin-releasing peptide receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100361,"[""Serine/threonine-protein kinase nek7""]",,"A serine/threonine-protein kinase Nek7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TDX7] |serine/threonine-protein kinase nek7 (NEK7)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300197,,,,,,,,"A serine/threonine-protein kinase Nek7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TDX7] |serine/threonine-protein kinase nek7 (NEK7)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100361,,,,https://pharos.nih.gov/idg/targets/Q8TDX7,,,,,,,,,,,,,NEK7,,,Q8TDX7,,,,,,,,Serine/threonine-protein kinase nek7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11875,"[""denture stomatitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_9637,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11875,,,,UMLS_CUI:C0038364|MESH:D013282|SNOMEDCT_US_2016_03_01:196576008|ICD10CM:K12.1|SNOMEDCT_US_2016_03_01:69254008,Denture sore mouth,,disease_ontology,,DOID:11875,,,,,,,,,,,,,,,,,,,denture stomatitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1852,"[""intrahepatic cholestasis""]",,Xref MGI.,false,,,http://purl.obolibrary.org/obo/DOID_13580|http://purl.obolibrary.org/obo/DOID_409,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1852,,,,SNOMEDCT_US_2016_03_01:4637005|ORDO:172|OMIM:615878|OMIM:614972|OMIM:211600|ORDO:65682|OMIM:243300|ORDO:69665|OMIM:602347|NCI:C84400|UMLS_CUI:C0008372|OMIM:147480|MESH:D002780|OMIM:601847|OMIM:605479,intrahepatic cholestasis of pregnancy,,disease_ontology,,DOID:1852,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,Xref MGI.,,intrahepatic cholestasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200402,"[""PEAK1 gene""]",,"This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and cancer metastasis. [provided by RefSeq, Mar 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400204,,,,,,,,"This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and cancer metastasis. [provided by RefSeq, Mar 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200402,,,,,,,,,,,,,,,,79834,PEAK1,KIAA2002,,,,,,,,,,PEAK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100377,"[""Olfactory receptor 4A16""]",,"An olfactory receptor 4A16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH70] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4A16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH70] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100377,,,,https://pharos.nih.gov/idg/targets/Q8NH70,,,,,,,,,,,,,OR4A16,,,Q8NH70,,,,,,,,Olfactory receptor 4A16,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200202,"[""GPR56 gene""]",,"A G-protein coupled receptor 56 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y653] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,"A G-protein coupled receptor 56 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y653] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200202,,,,,,,,,,,,,,,,9289,GPR56,TM7LN4|TM7XN1,,,,,,,,,,GPR56 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100131,"[""Golgi ph regulator a""]",,"A Golgi pH regulator A that is encoded in the genome of human. [PRO:DNx, UniProtKB:B7ZAQ6] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300350,,,,,,,,"A Golgi pH regulator A that is encoded in the genome of human. [PRO:DNx, UniProtKB:B7ZAQ6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100131,,,,https://pharos.nih.gov/idg/targets/B7ZAQ6,,,,,,,,,,,,,GPR89A,GPHRA|GPR89|SH120,,B7ZAQ6,,,,,,,,Golgi ph regulator a,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001814,"[""leaf tip""]",,The outer end of a leaf; the end that is opposite the petiole.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The outer end of a leaf; the end that is opposite the petiole.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001814,,,,,,,BrendaTissueOBO,leaf apex,BTO:0001814,,,,,,,,,,,,,,,,,,,leaf tip,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200131,"[""EPHA7 gene""]",,"This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400153,,,,,,,,"This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200131,,,,,,,,,,,,,,,,2045,EPHA7,EHK3|HEK11,,,,,,,,,,EPHA7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004249,"[""anterior cingulate cortex""]",,That portion of the cingulate cortex which is located within the frontal lobe (the remainder being in the parietal lobe). It is believed to be involved in the processing of attention.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,That portion of the cingulate cortex which is located within the frontal lobe (the remainder being in the parietal lobe). It is believed to be involved in the processing of attention.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004249,,,,,,,BrendaTissueOBO,ACC cell,BTO:0004249,,,,,,,,,,,,,,,,,,,anterior cingulate cortex,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001481,"[""plant""]",,Any of a kingdom (Plantae) of living things typically lacking locomotive movement or obvious nervous or sensory organs and possessing cellulose cell walls.,false,,,http://purl.obolibrary.org/obo/BTO_0000000|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Any of a kingdom (Plantae) of living things typically lacking locomotive movement or obvious nervous or sensory organs and possessing cellulose cell walls.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001481,,,,,,,BrendaTissueOBO,viridiplantae|plantae|Pflanze,BTO:0001481,,,,,,,,,,,,,,,,,,,plant,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100022,"[""Alk tyrosine kinase receptor""]",,"An ALK tyrosine kinase receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UM73] |alk tyrosine kinase receptor (ALK(L1196M))  with  mutation M1196 in ALK(L1196M) in a nonphosphorylated state|alk tyrosine kinase receptor (ALK)  with  no mutation  in a nonphosphorylated state|alk tyrosine kinase receptor (ALK(C1156Y))  with  mutation Y1156 in ALK(C1156Y) in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300122,,,,,,,,"An ALK tyrosine kinase receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UM73] |alk tyrosine kinase receptor (ALK(L1196M))  with  mutation M1196 in ALK(L1196M) in a nonphosphorylated state|alk tyrosine kinase receptor (ALK)  with  no mutation  in a nonphosphorylated state|alk tyrosine kinase receptor (ALK(C1156Y))  with  mutation Y1156 in ALK(C1156Y) in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100022,,,,https://pharos.nih.gov/idg/targets/Q9UM73,,,,,,,,,,,,,ALK,,,Q9UM73,,,,,,,,Alk tyrosine kinase receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200283,"[""NPY4R gene""]",,"A neuropeptide Y receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P50391] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400071,,,,,,,,"A neuropeptide Y receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P50391] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200283,,,,,,,,,,,,,,,,100996758|5540,NPY4R,PPYR1,,,,,,,,,,NPY4R gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100389,"[""Olfactory receptor 51B5""]",,"An olfactory receptor 51B5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H339] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 51B5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H339] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100389,,,,https://pharos.nih.gov/idg/targets/Q9H339,,,,,,,,,,,,,OR51B5,,,Q9H339,,,,,,,,Olfactory receptor 51B5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400468,"[""SCN3B family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400370,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400468,,,,,,,,,,,,,,,,,,,,,,,,,,,,SCN3B family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000124,"[""Neuropeptide Y-(3-36)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000124,,,,,,,,,,,,,,,,,,,,,,,,,,,,Neuropeptide Y-(3-36),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000238,"[""cerebrovascular endothelial cell""]",,Endothelial cell of or involving the cerebrum and the blood vessels supplying it.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001854,,,,,,,,Endothelial cell of or involving the cerebrum and the blood vessels supplying it.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000238,,,,,,,BrendaTissueOBO,,BTO:0000238,,,,,,,,,,,,,,,,,,,cerebrovascular endothelial cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200325,"[""MAPK13 gene""]",,"This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400294,,,,,,,,"This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200325,,,,,,,,,,,,,,,,5603,MAPK13,PRKM13|SAPK4,,,,,,,,,,MAPK13 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3948,"[""adrenocortical carcinoma""]",,An adrenal cortex cancer that forms in the outer layer of tissue of the adrenal gland and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.,false,,,http://purl.obolibrary.org/obo/DOID_660,,,,,,,,An adrenal cortex cancer that forms in the outer layer of tissue of the adrenal gland and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3948,,,,SNOMEDCT_US_2016_03_01:2227007|NCI:C9325|OMIM:202300|MESH:D018268|SNOMEDCT_US_2016_03_01:255035007|UMLS_CUI:C0206686,Adrenal cortical carcinoma (morphologic abnormality)|carcinoma of the Adrenal cortex,,disease_ontology,,DOID:3948,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,adrenocortical carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000079,"[""anther""]",,The male reproductive organ enclosing and containing the pollen grains.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The male reproductive organ enclosing and containing the pollen grains.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000079,,,,,,,BrendaTissueOBO,,BTO:0000079,,,,,,,,,,,,,,,,,,,anther,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200026,"[""ASIC2 gene""]",,"This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400377,,,,,,,,"This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200026,,,,,,,,,,,,,,,,40,ASIC2,ACCN|ACCN1|BNAC1|MDEG,,,,,,,,,,ASIC2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100179,"[""Uracil nucleotide/cysteinyl leukotriene receptor""]",,"A uracil nucleotide/cysteinyl leukotriene receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13304] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300033,,,,,,,,"A uracil nucleotide/cysteinyl leukotriene receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13304] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100179,,,,https://pharos.nih.gov/idg/targets/Q13304,,,,,,,,,,,,,GPR17,,,Q13304,,,,,,,,Uracil nucleotide/cysteinyl leukotriene receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000820,"[""C127I cell""]",,Mouse mammary gland cell line. C127I cells are suitable hosts for transformation with bovine papilloma virus DNA plasmids.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003568,,,,,,,,Mouse mammary gland cell line. C127I cells are suitable hosts for transformation with bovine papilloma virus DNA plasmids.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000820,,,,,,,BrendaTissueOBO,,BTO:0000820,,,,,,,,,,,,,,,,,,,C127I cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200336,"[""MAP2K3 gene""]",,"The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400194,,,,,,,,"The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200336,,,,,,,,,,,,,,,,5606,MAP2K3,MEK3|MKK3|PRKMK3,,,,,,,,,,MAP2K3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200023,"[""CHRM3 gene""]",,"A muscarinic acetylcholine receptor M3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P20309] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400020,,,,,,,,"A muscarinic acetylcholine receptor M3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P20309] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200023,,,,,,,,,,,,,,,,1131,CHRM3,,,,,,,,,,,CHRM3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200397,"[""PDK3 gene""]",,"The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400131,,,,,,,,"The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200397,,,,,,,,,,,,,,,,5165,PDK3,PDHK3,,,,,,,,,,PDK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9602,"[""necrotizing fasciitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_9598,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9602,,,,ICD9CM:728.86|SNOMEDCT_US_2016_03_01:186428007|MESH:D019115|SNOMEDCT_US_2016_03_01:52486002|ICD10CM:M72.6|UMLS_CUI:C0238124|NCI:C84916,,,disease_ontology,,DOID:9602,http://purl.obolibrary.org/obo/doid#gram-positive_bacterial_infectious_disease,,,,,,,,,,,,,,,,,,necrotizing fasciitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001037,"[""sensory cell""]",,"1: A peripheral nerve cell, as an olfactory cell, located at a sensory receiving surface and being the primary receptor of a sensory impulse. 2: A nerve cell, as a spinal ganglion cell, transmitting sensory impulses.",false,,,http://purl.obolibrary.org/obo/BTO_0000938|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"1: A peripheral nerve cell, as an olfactory cell, located at a sensory receiving surface and being the primary receptor of a sensory impulse. 2: A nerve cell, as a spinal ganglion cell, transmitting sensory impulses.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001037,,,,,,,BrendaTissueOBO,sensory neuron,BTO:0001037,,,,,,,,,,,,,,,,,,,sensory cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_77,"[""gastrointestinal system disease""]",,A disease of anatomical entity that is located_in the gastrointestinal tract.,false,,,http://purl.obolibrary.org/obo/DOID_7,,,,,,,,A disease of anatomical entity that is located_in the gastrointestinal tract.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:77,,,DOID:27|DOID:944,SNOMEDCT_US_2016_03_01:155629009|SNOMEDCT_US_2016_03_01:266483008|SNOMEDCT_US_2016_03_01:155847001|UMLS_CUI:C0012242|ICD10CM:K92.9|MESH:D004066|SNOMEDCT_US_2016_03_01:197575000|ICD9CM:520-579.99|SNOMEDCT_US_2016_03_01:53619000,GIT disease|gastrointestinal disease|Gastroenteropathy|gastrointestinal disorder|digestive system disorder|alimentary system disease,,disease_ontology,,DOID:77,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,gastrointestinal system disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_778,"[""delusional disorder""]",,"A psychotic disorder that involves an uncommon psychiatric condition in which patients present with circumscribed symptoms of non-bizarre delusions, but with the absence of prominent hallucinations and no thought disorder, mood disorder, or significant flattening effect.",false,,,http://purl.obolibrary.org/obo/DOID_2468,,,,,,,,"A psychotic disorder that involves an uncommon psychiatric condition in which patients present with circumscribed symptoms of non-bizarre delusions, but with the absence of prominent hallucinations and no thought disorder, mood disorder, or significant flattening effect.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:778,,,,NCI:C94379|ICD9CM:297.1|MESH:D012563|UMLS_CUI:C0011251|SNOMEDCT_US_2016_03_01:48500005|SNOMEDCT_US_2016_03_01:192330005|ICD10CM:F22,,,disease_ontology,,DOID:778,,,,,,,,,,,,,,,,,,,delusional disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_771,"[""retinal cell cancer""]",,A malignant neoplasm that derives_from the retina.,false,,,http://purl.obolibrary.org/obo/DOID_4645,,,,,,,,A malignant neoplasm that derives_from the retina.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:771,,,,NCI:C7061|UMLS_CUI:C1335765,,,disease_ontology,,DOID:771,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,retinal cell cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000205,"[""MET80 in NEK5""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000205,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET80 in NEK5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200138,"[""GPR124 gene""]",,"A G-protein coupled receptor 124 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96PE1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,"A G-protein coupled receptor 124 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96PE1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200138,,,,,,,,,,,,,,,,25960,GPR124,KIAA1531|TEM5,,,,,,,,,,GPR124 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100282,"[""Neuropeptide y receptor type 2""]",,"A neuropeptide Y receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49146] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300071,,,,,,,,"A neuropeptide Y receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49146] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100282,,,,https://pharos.nih.gov/idg/targets/P49146,,,,,,,,,,,,,NPY2R,,,P49146,,,,,,,,Neuropeptide y receptor type 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300323,"[""Lipid kinase""]",,A lipid kinase is a kinase enzyme that catalyzes the phosphorylation of a lipid substrate.,false,,,http://www.drugtargetontology.org/dto/DTO_03300103,,,,,,,,A lipid kinase is a kinase enzyme that catalyzes the phosphorylation of a lipid substrate.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300323,,,,,,,,,,,,,,,,,,,,,,,,,,,,Lipid kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300277,"[""PKC delta subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300175,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300277,,,,,,,,,,,,,,,,,,,,,,,,,,,,PKC delta subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200383,"[""OR4F21 gene""]",,"An olfactory receptor 4F21 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95013] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4F21 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95013] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200383,,,,,,,,,,,,,,,,441308,OR4F21,OR4F21P,,,,,,,,,,OR4F21 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200100,"[""FPR3 gene""]",,"An N-formyl peptide receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25089] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400041,,,,,,,,"An N-formyl peptide receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25089] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200100,,,,,,,,,,,,,,,,2359,FPR3,FPRH1|FPRL2,,,,,,,,,,FPR3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300257,"[""CDK8 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300136,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300257,,,,,,,,,,,,,,,,,,,,,,,,,,,,CDK8 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100192,"[""Probable G-protein coupled receptor 34""]",,"A G-protein coupled receptor 34 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UPC5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 34 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UPC5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100192,,,,https://pharos.nih.gov/idg/targets/Q9UPC5,,,,,,,,,,,,,GPR34,,,Q9UPC5,,,,,,,,Probable G-protein coupled receptor 34,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200737,"[""F2R gene""]",,"A proteinase-activated receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25116] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002|http://www.drugtargetontology.org/dto/DTO_02400079,,,,,,,,"A proteinase-activated receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25116] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200737,,,,,,,,,,,,,,,,2149,F2R,CF2R|PAR1|TR,,,,,,,,,,F2R gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200726,"[""P2RY1 gene""]",,"A P2Y purinoceptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47900] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400100,,,,,,,,"A P2Y purinoceptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47900] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200726,,,,,,,,,,,,,,,,5028,P2RY1,,,,,,,,,,,P2RY1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004915,"[""ZR-75-30 cell""]",,Human mammary gland ductal carcinoma cell line; derived from malignant ascites fluid from a 47-year-old premenopausal Black woman with infiltrating ductal carcinoma.,false,,,http://purl.obolibrary.org/obo/BTO_0004086|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human mammary gland ductal carcinoma cell line; derived from malignant ascites fluid from a 47-year-old premenopausal Black woman with infiltrating ductal carcinoma.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004915,Marion Gremse,2010-10-27T10:23:56Z,,,,,BrendaTissueOBO,ZR75-30 cell,BTO:0004915,,,,,,,,,,,,,,,,,,,ZR-75-30 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217557,"[""NR2E3 gene""]",,"This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_00217470,,,,,,,,"This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217557,,,,,,,,,,,,,,,,10002,NR2E3,PNR|RNR,,,,,,,,,,NR2E3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3627,"[""aortic aneurysm""]",,An aortic disease that is characterized by an enlargement (dilation) of the aorta to greater than 1.5 times normal size.,false,,,http://purl.obolibrary.org/obo/DOID_520,,,,,,,,An aortic disease that is characterized by an enlargement (dilation) of the aorta to greater than 1.5 times normal size.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3627,,,DOID:7703|DOID:7692|DOID:7682|DOID:11138,UMLS_CUI:C1305122|ICD10CM:I71.3|ICD9CM:441.6|MESH:D001014|ICD10CM:I71.9|UMLS_CUI:C0265012|SNOMEDCT_US_2016_03_01:195615002|NCI:C27299|ICD10CM:I71.1|UMLS_CUI:C0265010|NCI:C26697|SNOMEDCT_US_2016_03_01:195258006|ICD10CM:I71.5|ICD10CM:I71.8|SNOMEDCT_US_2016_03_01:73067008|ICD9CM:441.5|SNOMEDCT_US_2016_03_01:155419006|MESH:D001019|UMLS_CUI:C0741160|SNOMEDCT_US_2016_03_01:155424009|NCI:C27198|UMLS_CUI:C0003486|SNOMEDCT_US_2016_03_01:67362008|SNOMEDCT_US_2016_03_01:14336007|SNOMEDCT_US_2016_03_01:34365005|ICD9CM:441.3|ICD9CM:441.1|SNOMEDCT_US_2016_03_01:195265003|NCI:C27046|SNOMEDCT_US_2016_03_01:195264004|SNOMEDCT_US_2016_03_01:195269009|SNOMEDCT_US_2016_03_01:155423003,"ruptured thoracic aortic aneurysm|Ruptured abdominal aortic aneurysm (disorder)|ruptured abdominal aortic aneurysm|Aortic aneurysm of unspecified site, ruptured|Ruptured aortic aneurysm NOS (disorder)|abdominal aortic aneurysm, ruptured|Ruptured thoracic aortic aneurysm (disorder)|Aortic aneurysm of unspecified site, ruptured (disorder)|Ruptured abdominal Aortic Aneurysm|Thoracoabdominal aortic aneurysm, ruptured (disorder)|Ruptured Thoracic Aneurysm|Ruptured aortic aneurysm (disorder)|ruptured thoracoabdominal aortic aneurysm|Thoracic aortic aneurysm which has ruptured (disorder)|Ruptured aortic aneurysm NOS|Thoracic aortic aneurysm, ruptured|Ruptured Aortic Aneurysm|ruptured aortic aneurysm",,disease_ontology,,DOID:3627,,,,,,,,,,,,,,,,,,,aortic aneurysm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200290,"[""OR10A4 gene""]",,"An olfactory receptor 10A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H209] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H209] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200290,,,,,,,,,,,,,,,,283297,OR10A4,OR10A4P,,,,,,,,,,OR10A4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200270,"[""TACR1 gene""]",,"A substance-P receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25103] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400066,,,,,,,,"A substance-P receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25103] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200270,,,,,,,,,,,,,,,,6869,TACR1,NK1R|TAC1R,,,,,,,,,,TACR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2846,"[""bruxism""]",,A sleep disorder that involves involuntarily grinding or clenching of the teeth while sleeping.,false,,,http://purl.obolibrary.org/obo/DOID_535,,,,,,,,A sleep disorder that involves involuntarily grinding or clenching of the teeth while sleeping.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2846,,,DOID:8891,MESH:D020186|ICD10CM:G47.63|MESH:D002012|UMLS_CUI:C0006325|SNOMEDCT_US_2016_03_01:367105000|SNOMEDCT_US_2016_03_01:191983006|UMLS_CUI:C0393774|SNOMEDCT_US_2016_03_01:268774006|ICD9CM:327.53|SNOMEDCT_US_2016_03_01:154925009|SNOMEDCT_US_2016_03_01:274950005|ICD10CM:F45.8|SNOMEDCT_US_2016_03_01:90207007|NCI:C73511|SNOMEDCT_US_2016_03_01:192436003,sleep related bruxism|Bruxism - teeth grinding|Teeth grinding|Grinding teeth,,disease_ontology,,DOID:2846,,,,,,,,,,,,,,,,,,,bruxism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000044,"[""LEU120 in AURKC""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000044,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU120 in AURKC,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003365,"[""germinated grain""]",,"After germination, the grain of barley is called green malt.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000208,,,,,,,,"After germination, the grain of barley is called green malt.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003365,,,,,,,BrendaTissueOBO,green malt,BTO:0003365,,,,,,,,,,,,,,,,,,,germinated grain,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000251,"[""chorioallantois""]",,A vascular fetal membrane composed of the fused chorion and adjacent wall of the allantois that in the hen's egg is used as a living culture medium for viruses and for tissues.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000473,,,,,,,,A vascular fetal membrane composed of the fused chorion and adjacent wall of the allantois that in the hen's egg is used as a living culture medium for viruses and for tissues.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000251,,,,,,,BrendaTissueOBO,chorioallantoic membrane,BTO:0000251,,,,,,,,,,,,,,,,,,,chorioallantois,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000462,"[""YANK1 kinase domain""]",,Serine/threonine kinase 32A; MGC22688; STK32A; YANK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine kinase 32A; MGC22688; STK32A; YANK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000462,,,,,,,,,,,,,,,,,,,200462,,,,,,,,,YANK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100330,"[""Olfactory receptor 11h1""]",,"An olfactory receptor 11H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG94] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 11H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG94] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100330,,,,https://pharos.nih.gov/idg/targets/Q8NG94,,,,,,,,,,,,,OR11H1,,,Q8NG94,,,,,,,,Olfactory receptor 11h1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100173,"[""Homeodomain-interacting protein kinase 2""]",,"A homeodomain-interacting protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H2X6] |homeodomain-interacting protein kinase 2 (HIPK2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300273,,,,,,,,"A homeodomain-interacting protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H2X6] |homeodomain-interacting protein kinase 2 (HIPK2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100173,,,,https://pharos.nih.gov/idg/targets/Q9H2X6,,,,,,,,,,,,,HIPK2,,,Q9H2X6,,,,,,,,Homeodomain-interacting protein kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1520,"[""colon carcinoma""]",,A colon cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.,false,,,http://purl.obolibrary.org/obo/DOID_305|http://purl.obolibrary.org/obo/DOID_219,,,,,,,,A colon cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1520,,,,SNOMEDCT_US_2016_03_01:154454005|NCI:C4910|SNOMEDCT_US_2016_03_01:269533000|UMLS_CUI:C0699790|OMIM:114500,Colonic carcinoma|carcinoma of colon|carcinoma of colon (disorder)|carcinoma OF colon,,disease_ontology,,DOID:1520,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,colon carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400202,"[""NKF4 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400202,,,,,,,,,,,,,,,,,,,,,,,,,,,,NKF4 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200217,"[""GPR98 gene""]",,"A G-protein coupled receptor 98 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WXG9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,"A G-protein coupled receptor 98 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WXG9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200217,,,,,,,,,,,,,,,,84059,GPR98,KIAA0686|KIAA1943|MASS1|VLGR1,,,,,,,,,,GPR98 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100214,"[""Potassium channel subfamily K member 2""]",,"A potassium channel subfamily K member 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95069] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300359,,,,,,,,"A potassium channel subfamily K member 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95069] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100214,,,,https://pharos.nih.gov/idg/targets/O95069,,,,,,,,,,,,,KCNK2,TREK|TREK1,,O95069,,,,,,,,Potassium channel subfamily K member 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200013,"[""ADORA1 gene""]",,"An adenosine receptor A1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30542] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400018,,,,,,,,"An adenosine receptor A1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30542] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200013,,,,,,,,,,,,,,,,134,ADORA1,,,,,,,,,,,ADORA1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300278,"[""PKC eta subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300175,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300278,,,,,,,,,,,,,,,,,,,,,,,,,,,,PKC eta subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000255,"[""PHE243 in CLK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000255,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE243 in CLK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100222,"[""Calcium/calmodulin-dependent protein kinase type iv""]",,"A calcium/calmodulin-dependent protein kinase type IV that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16566] |calcium/calmodulin-dependent protein kinase type iv (KCC4)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300171,,,,,,,,"A calcium/calmodulin-dependent protein kinase type IV that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16566] |calcium/calmodulin-dependent protein kinase type iv (KCC4)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100222,,,,https://pharos.nih.gov/idg/targets/Q16566,,,,,,,,,,,,,CAMK4,CAMK|CAMK-GR|CAMKIV,,Q16566,,,,,,,,Calcium/calmodulin-dependent protein kinase type iv,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100076,"[""Cyclin-dependent kinase-like 1""]",,"cyclin-dependent kinase-like 1 (CDKL1)  with  no mutation  in a nonphosphorylated state|A cyclin-dependent kinase-like 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q00532] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300138,,,,,,,,"cyclin-dependent kinase-like 1 (CDKL1)  with  no mutation  in a nonphosphorylated state|A cyclin-dependent kinase-like 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q00532] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100076,,,,https://pharos.nih.gov/idg/targets/Q00532,,,,,,,,,,,,,CDKL1,,,Q00532,,,,,,,,Cyclin-dependent kinase-like 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_299,"[""adenocarcinoma""]",,"A carcinoma that has_material_basis_in abnormally proliferating cells, derives_from epithelial cells, which originate in glandular tissue.",false,,,http://purl.obolibrary.org/obo/DOID_305,,,,,,,,"A carcinoma that has_material_basis_in abnormally proliferating cells, derives_from epithelial cells, which originate in glandular tissue.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:299,,,,UMLS_CUI:C0001418|NCI:C2852|MESH:D000230|SNOMEDCT_US_2016_03_01:189578007|SNOMEDCT_US_2016_03_01:189582009|CSP:2000-0386|SNOMEDCT_US_2016_03_01:35917007|SNOMEDCT_US_2016_03_01:443961001,"adenocarcinoma, no subtype (morphologic abnormality)|adenocarcinoma NOS (morphologic abnormality)|adenocarcinomas",,disease_ontology,,DOID:299,,,,,,,,,,,,,,,,,,,adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117460,"[""Thyroid hormone receptors""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00102000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117460,,,,,,,,,,,,,,,,,,,,,,,,,,,,Thyroid hormone receptors,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02302002,"[""5-HT2 receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300017,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02302002,,,,,,,,,,,,,,,,,,,,,,,,,,,,5-HT2 receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02402005,"[""5-HT6 receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400017,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02402005,,,,,,,,,,,,,,,,,,,,,,,,,,,,5-HT6 receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000310,"[""THR219 in NLK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000310,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR219 in NLK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400233,"[""NKF5 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400233,,,,,,,,,,,,,,,,,,,,,,,,,,,,NKF5 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004602,"[""human aortic endothelial cell""]",,Human aortic endothelial cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003246,,,,,,,,Human aortic endothelial cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004602,mgr,2010-04-13T09:34:08Z,,,,,BrendaTissueOBO,HAEC cell,BTO:0004602,,,,,,,,,,,,,,,,,,,human aortic endothelial cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/UBERON_0002369,"[""adrenal gland""]",glandula suprarenalis|adrenal medulla cell|interrenal gland|adrenal|suprarenal capsule|epinephric gland|epinephros|adrenal capsule|atrabiliary capsule|suprarenal gland,"Either of a pair of complex endocrine organs near the anterior medial border of the kidney consisting of a mesodermal cortex that produces glucocorticoid, mineralocorticoid, and androgenic hormones and an ectodermal medulla that produces epinephrine and norepinephrine[BTO].",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001491|http://purl.obolibrary.org/obo/UBERON_0001062|http://purl.obolibrary.org/obo/BTO_0001488,,,,,,,http://linkedlifedata.com/resource/umls/id/C0001625|http://www.snomedbrowser.com/Codes/Details/181127006|http://en.wikipedia.org/wiki/Adrenal_gland|EMAPA:18426|MIAA:0000071|OpenCyc:Mx4rvXYiz5wpEbGdrcN5Y29ycA|GAID:446|ncithesaurus:Adrenal_Gland|galen:AdrenalGland|MESH:A06.407.071|AAO:0010551|FMA:9604|EFO:0000238|BTO:0000047|UMLS:C0001625|EV:0100135|MAT:0000071|CALOHA:TS-0016|VHOG:0001141|MA:0000116|XAO:0000164,"Either of a pair of complex endocrine organs near the anterior medial border of the kidney consisting of a mesodermal cortex that produces glucocorticoid, mineralocorticoid, and androgenic hormones and an ectodermal medulla that produces epinephrine and norepinephrine[BTO].",,http://upload.wikimedia.org/wikipedia/commons/thumb/c/c6/Illu_endocrine_system.jpg/200px-Illu_endocrine_system.jpg|http://upload.wikimedia.org/wikipedia/commons/9/9d/Illu_endocrine_system_New.png,,,,,,,,"Anatomical structure which is found on the surface of the kidney and secretes various hormones including epinephrine, norephinephrine, aldosterone, corticosterone, and cortisol.[AAO]",,,,,,,,,,,,,,,,,,,,,,,,,,glandula suprarenalis|glandula adrenalis,,uberon,glandula suprarenalis|adrenal medulla cell|interrenal gland|adrenal|suprarenal capsule|epinephric gland|epinephros|adrenal capsule|atrabiliary capsule|suprarenal gland,,"All craniates have groups of cells homologous to the mammalian adrenocortical and chromaffin tissues, but they are scattered in and near the kidneys in fishes. (...) The cortical and chromaffin tissues come together to form adrenal glands in tetrapods.[well established][VHOG]",,,,,,,,,,,,,,,,,,,,,,,,UBERON:0002369,,,"Taxon notes: The origin of the adrenal gland is still controversial. It is thought to share the same origin as the kidney and gonads, derived from coelomic epithelium of the urogenital ridge and/or the underlying mesenchyme (Keegan and Hammer, 2002; Morohashi, 1997). We follow Kardong and state homology at the level of the cortex and medulla rather than gland as a whole",,adrenal gland,,UBERON:0002369,,http://purl.obolibrary.org/obo/uberon.owl,http://purl.obolibrary.org/obo/uberon/core#organ_slim|http://purl.obolibrary.org/obo/uberon/core#uberon_slim,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/UBERON_0002367,"[""prostate gland""]",prostata,"The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062|http://purl.obolibrary.org/obo/BTO_0000080|http://purl.obolibrary.org/obo/BTO_0003096,,,,,,,http://en.wikipedia.org/wiki/Prostate|http://linkedlifedata.com/resource/umls/id/C0033572|http://www.snomedbrowser.com/Codes/Details/181422007|UMLS:C0033572|ncithesaurus:Prostate_Gland|EMAPA:19287|BTO:0001129|MESH:A05.360.444.575|galen:ProstateGland|OpenCyc:Mx4rv6trqZwpEbGdrcN5Y29ycA|MIAA:0000078|CALOHA:TS-0828|GAID:392|EV:0100104|MA:0000404|VHOG:0001261|FMA:9600|EFO:0000858|MAT:0000078,"The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid.",,http://upload.wikimedia.org/wikipedia/commons/thumb/a/a1/Prostatelead.jpg/200px-Prostatelead.jpg|http://upload.wikimedia.org/wikipedia/commons/a/a1/Prostatelead.jpg,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,male prostate|prostate,,uberon,prostata,prostatic,,,,,,,,,,,,,,,,,,,,,,,,,UBERON:0002367,,,TODO - FMA treats the gland as part of the prostate - see also FMA:74119.,,prostate gland,,UBERON:0002367,,http://purl.obolibrary.org/obo/uberon.owl,http://purl.obolibrary.org/obo/uberon/core#efo_slim|http://purl.obolibrary.org/obo/uberon/core#organ_slim|http://purl.obolibrary.org/obo/uberon/core#major_organ|http://purl.obolibrary.org/obo/uberon/core#uberon_slim,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200567,"[""WNK1 gene""]",,"This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400244,,,,,,,,"This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200567,,,,,,,,,,,,,,,,65125,WNK1,HSN2|KDP|KIAA0344,,,,,,,,,,WNK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100379,"[""Phosphatidylinositol 4-phosphate 3-kinase c2 domain-containing subunit beta""]",,"phosphatidylinositol 4-phosphate 3-kinase c2 domain-containing subunit beta (PIK3C2B)  with  no mutation  in a nonphosphorylated state|A phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00750] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391009,,,,,,,,"phosphatidylinositol 4-phosphate 3-kinase c2 domain-containing subunit beta (PIK3C2B)  with  no mutation  in a nonphosphorylated state|A phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00750] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100379,,,,https://pharos.nih.gov/idg/targets/O00750,,,,,,,,,,,,,PIK3C2B,,,O00750,,,,,,,,Phosphatidylinositol 4-phosphate 3-kinase c2 domain-containing subunit beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4752,"[""multiple system atrophy""]",,OMIM mapping confirmed by DO. [LS].,false,,,http://purl.obolibrary.org/obo/DOID_0050890,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4752,,,DOID:11510,NCI:C84909|MESH:D012791|NCI:C85066|SNOMEDCT_US_2016_03_01:16576004|UMLS_CUI:C0037019|OMIM:146500|SNOMEDCT_US_2016_03_01:230297002|MESH:D019578|UMLS_CUI:C0393571,Shy-Drager syndrome|Multiple system atrophy (disorder),,disease_ontology,,DOID:4752,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,multiple system atrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_520,"[""aortic disease""]",,An artery disease that is characterized by degeneration of the cells composing the aortic wall.,false,,,http://purl.obolibrary.org/obo/DOID_0050828,,,,,,,,An artery disease that is characterized by degeneration of the cells composing the aortic wall.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:520,,,,NCI:C101253|SNOMEDCT_US_2016_03_01:47040006|MESH:D001018|UMLS_CUI:C0003493,aortic disorder|disorder of the aorta (disorder),,disease_ontology,,DOID:520,,,,,,,,,,,,,,,,,,,aortic disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_526,"[""human immunodeficiency virus infectious disease""]",,"A viral infectious disease that results_in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has_symptom diarrhea, has_symptom fatigue, has_symptom fever, has_symptom vaginal yeast infection, has_symptom headache, has_symptom mouth sores, has_symptom muscle aches, has_symptom sore throat, and has_symptom swollen lymph glands.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has_symptom diarrhea, has_symptom fatigue, has_symptom fever, has_symptom vaginal yeast infection, has_symptom headache, has_symptom mouth sores, has_symptom muscle aches, has_symptom sore throat, and has_symptom swollen lymph glands.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:526,,,,ICD10CM:B20-B20|SNOMEDCT_US_2016_03_01:86406008|SNOMEDCT_US_2016_03_01:187438009|NCI:C3108|MESH:D015658|ICD9CM:042-042.99|SNOMEDCT_US_2016_03_01:123321001|ICD10CM:B20|UMLS_CUI:C0019693|ICD9CM:042|SNOMEDCT_US_2016_03_01:186705005|SNOMEDCT_US_2016_03_01:187453001,HIV infection,,disease_ontology,,DOID:526,http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,human immunodeficiency virus infectious disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1287,"[""cardiovascular system disease""]",,"A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.",false,,,http://purl.obolibrary.org/obo/DOID_7,,,,,,,,"A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1287,,,DOID:73,ICD9CM:429.2|UMLS_CUI:C0007222|SNOMEDCT_US_2016_03_01:195594006|SNOMEDCT_US_2016_03_01:266336005|SNOMEDCT_US_2016_03_01:155263000|NCI:C2931|SNOMEDCT_US_2016_03_01:195139006|SNOMEDCT_US_2016_03_01:49601007|SNOMEDCT_US_2016_03_01:194707003|SNOMEDCT_US_2016_03_01:266275004|MESH:D002318,disease of subdivision of hemolymphoid system,,disease_ontology,,DOID:1287,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,cardiovascular system disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200027,"[""ANKK1 gene""]",,"The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal transduction pathways. This gene is closely linked to DRD2 gene (GeneID:1813) on chr 11, and a well studied restriction fragment length polymorphism (RFLP) designated TaqIA, was originally associated with the DRD2 gene, however, later was determined to be located in exon 8 of ANKK1 gene (PMIDs: 18621654, 15146457), where it causes a nonconservative amino acid substitution. It is not clear if this gene plays any role in neuropsychiatric disorders previously associated with Taq1A RFLP. [provided by RefSeq, Sep 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400124,,,,,,,,"The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal transduction pathways. This gene is closely linked to DRD2 gene (GeneID:1813) on chr 11, and a well studied restriction fragment length polymorphism (RFLP) designated TaqIA, was originally associated with the DRD2 gene, however, later was determined to be located in exon 8 of ANKK1 gene (PMIDs: 18621654, 15146457), where it causes a nonconservative amino acid substitution. It is not clear if this gene plays any role in neuropsychiatric disorders previously associated with Taq1A RFLP. [provided by RefSeq, Sep 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200027,,,,,,,,,,,,,,,,255239,ANKK1,PKK2|SGK288,,,,,,,,,,ANKK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80347,"[""Dynorphin B""]",Rimorphin,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,CAS:83335-41-5|KEGG:C16135,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,Rimorphin,,,CHEBI:80347,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80347,,,,,Dynorphin B,,CHEBI:80347,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100147,"[""Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4""]",,"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9Y3Q4] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300343,,,,,,,,"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9Y3Q4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100147,,,,https://pharos.nih.gov/idg/targets/Q9Y3Q4,,,,,,,,,,,,,HCN4,,,Q9Y3Q4,,,,,,,,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060352,"[""Kleefstra syndrome""]",,"A syndrome characterized by childhood hypotonia, a distinctive facial appearance, speech impediments and developmental disability, as well as epilepsy, congenital and urogenetic defects, microcephaly, corpulence, and psychiatric disorders. It is caused either by a microdeletion in the chromosome region 9q34.3 or by a point mutation in the EHMT1 gene located in that region.",false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,"A syndrome characterized by childhood hypotonia, a distinctive facial appearance, speech impediments and developmental disability, as well as epilepsy, congenital and urogenetic defects, microcephaly, corpulence, and psychiatric disorders. It is caused either by a microdeletion in the chromosome region 9q34.3 or by a point mutation in the EHMT1 gene located in that region.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060352,elvira,2015-07-14T16:49:09Z,,OMIM:610253|ORDO:261494|UMLS_CUI:C0795833|MESH:C563043,9q subtelomeric deletion syndrome|9q34 deletion syndrome|9q-syndrome,,disease_ontology,,DOID:0060352,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,Kleefstra syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060358,"[""multiple acyl-CoA dehydrogenase deficiency""]",,"An inherited metabolic disorder characterized by the body's inability to break down proteins and fats to produce energy. It is a disorder of fatty acid, amino acid, and choline metabolism and has an autosomal recessive inheritance pattern. It has material basis in mutations in the ETFA, ETFB and ETFDH genes. It presents three clinical phenotypes: a neonatal-onset form with congenital anomalies (type I), a neonatal-onset form without congenital anomalies (type II), and a late-onset form (type III). The neonatal-onset forms are usually fatal.",false,,,http://purl.obolibrary.org/obo/DOID_655,,,,,,,,"An inherited metabolic disorder characterized by the body's inability to break down proteins and fats to produce energy. It is a disorder of fatty acid, amino acid, and choline metabolism and has an autosomal recessive inheritance pattern. It has material basis in mutations in the ETFA, ETFB and ETFDH genes. It presents three clinical phenotypes: a neonatal-onset form with congenital anomalies (type I), a neonatal-onset form without congenital anomalies (type II), and a late-onset form (type III). The neonatal-onset forms are usually fatal.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060358,elvira,2015-08-20T16:23:47Z,,UMLS_CUI:C0268596|ICD10CM:E71.313|MESH:D054069|NCI:C99102|UMLS_CUI:C1856405|NCI:C84907|SNOMEDCT_US_2016_03_01:22886006|UMLS_CUI:C1856403|OMIM:231680|ORDO:26791|UMLS_CUI:C1856401,glutaric aciduria type 2|MADD|MAD deficiency|electron transfer flavoprotein deficiency|glutaric acidemia type 2|electron transfer flavoprotein ubiquinone oxidoreductase deficiency,,disease_ontology,,DOID:0060358,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,multiple acyl-CoA dehydrogenase deficiency,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060354,"[""Stormorken syndrome""]",,"A blood platelet disease characterized by  thrombocytopathy, thrombocytopenia, mild anemia, asplenia, tubular aggregate myopathy, miosis, headache, and ichthyosis. It has material basis in heterozygous mutation in the STM1 gene on chromosome 11p15. It has an autosomal dominant inheritance pattern.",false,,,http://purl.obolibrary.org/obo/DOID_2218,,,,,,,,"A blood platelet disease characterized by  thrombocytopathy, thrombocytopenia, mild anemia, asplenia, tubular aggregate myopathy, miosis, headache, and ichthyosis. It has material basis in heterozygous mutation in the STM1 gene on chromosome 11p15. It has an autosomal dominant inheritance pattern.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060354,elvira,2015-07-16T16:30:32Z,,OMIM:185070|MESH:C566108|UMLS_CUI:C1861451|SNOMEDCT_US_2016_03_01:711407000|ORDO:3204,"thrombocytopathy, asplenia and miosis",,disease_ontology,,DOID:0060354,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,Stormorken syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001136,"[""proventriculus""]",,1: The glandular or true stomach of a bird that is situated between the crop and gizzard. 2: A muscular dilatation of the foregut in most mandibulate insects that is armed internally with chitinous teeth or plates for triturating food. 3: The thin-walled sac in front of the gizzard of an earthworm.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,1: The glandular or true stomach of a bird that is situated between the crop and gizzard. 2: A muscular dilatation of the foregut in most mandibulate insects that is armed internally with chitinous teeth or plates for triturating food. 3: The thin-walled sac in front of the gizzard of an earthworm.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001136,,,,,,,BrendaTissueOBO,,BTO:0001136,,,,,,,,,,,,,,,,,,,proventriculus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200199,"[""PFKL gene""]",,"This gene encodes the liver (L) subunit of an enzyme that catalyzes the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate, which is a key step in glucose metabolism (glycolysis). This enzyme is a tetramer that may be composed of different subunits encoded by distinct genes in different tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_0349989,,,,,,,,"This gene encodes the liver (L) subunit of an enzyme that catalyzes the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate, which is a key step in glucose metabolism (glycolysis). This enzyme is a tetramer that may be composed of different subunits encoded by distinct genes in different tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200199,,,,,,,,,,,,,,,,5211,PFKL,,,,,,,,,,,PFKL gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300238,"[""TSSK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300238,,,,,,,,,,,,,,,,,,,,,,,,,,,,TSSK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000072,"[""LEU431 in DCAMKL3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000072,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU431 in DCAMKL3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9974,"[""drug dependence""]",,A substance dependence that involves the continued use of drugs despite problems related to use of the substance.,false,,,http://purl.obolibrary.org/obo/DOID_9973,,,,,,,,A substance dependence that involves the continued use of drugs despite problems related to use of the substance.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9974,,,,SNOMEDCT_US_2016_03_01:191864000|SNOMEDCT_US_2016_03_01:191859004|UMLS_CUI:C0029792|SNOMEDCT_US_2016_03_01:191860009|ICD9CM:304.6|ICD9CM:304.60|SNOMEDCT_US_2016_03_01:268644006,,,disease_ontology,,DOID:9974,,,,,,,,,,,,,,,,,,,drug dependence,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005136,"[""ES-E14 cell""]",,Mouse embryonic stem cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001581,,,,,,,,Mouse embryonic stem cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005136,XPMUser,2011-05-11T10:03:05Z,,,,,BrendaTissueOBO,E14 cell|E-14 cell,BTO:0005136,,,,,,,,,,,,,,,,,,,ES-E14 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002731,"[""erythroid cell""]",,Cell that will give rise to erythrocytes.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000574,,,,,,,,Cell that will give rise to erythrocytes.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002731,,,,,,,BrendaTissueOBO,,BTO:0002731,,,,,,,,,,,,,,,,,,,erythroid cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000105,"[""MET1103 in INSR""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000105,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET1103 in INSR,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100179,"[""Serine/threonine-protein kinase ick""]",,"A serine/threonine-protein kinase ICK that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UPZ9] |serine/threonine-protein kinase ick (ICK)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300162,,,,,,,,"A serine/threonine-protein kinase ICK that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UPZ9] |serine/threonine-protein kinase ick (ICK)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100179,,,,https://pharos.nih.gov/idg/targets/Q9UPZ9,,,,,,,,,,,,,ICK,KIAA0936,,Q9UPZ9,,,,,,,,Serine/threonine-protein kinase ick,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000117,"[""DYRK1A kinase domain""]",,Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; DYRK; DYRK1; DYRK1A; HP86; MNB; MNBH,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; DYRK; DYRK1; DYRK1A; HP86; MNB; MNBH,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000117,,,,,,,,,,,,,,,,,,,200119,,,,,,,,,DYRK1A kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100233,"[""Histamine H4 receptor""]",,"An H4 histamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H3N8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300061,,,,,,,,"An H4 histamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H3N8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100233,,,,https://pharos.nih.gov/idg/targets/Q9H3N8,,,,,,,,,,,,,HRH4,GPCR105,,Q9H3N8,,,,,,,,Histamine H4 receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200593,"[""OR4K5 gene""]",,"An olfactory receptor 4K5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4K5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200593,,,,,,,,,,,,,,,,79317,OR4K5,,,,,,,,,,,OR4K5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100392,"[""Pas domain-containing serine/threonine-protein kinase""]",,"A PAS domain-containing serine/threonine-protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RG2] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300305,,,,,,,,"A PAS domain-containing serine/threonine-protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RG2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100392,,,,https://pharos.nih.gov/idg/targets/Q96RG2,,,,,,,,,,,,,PASK,KIAA0135,,Q96RG2,,,,,,,,Pas domain-containing serine/threonine-protein kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200739,"[""F2RL2 gene""]",,"A proteinase-activated receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00254] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002|http://www.drugtargetontology.org/dto/DTO_02400079,,,,,,,,"A proteinase-activated receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00254] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200739,,,,,,,,,,,,,,,,2151,F2RL2,PAR3,,,,,,,,,,F2RL2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001152,"[""radicle""]",,The lower part of the axis of a plant embryo or seedling.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The lower part of the axis of a plant embryo or seedling.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001152,,,,,,,BrendaTissueOBO,,BTO:0001152,,,,,,,,,,,,,,,,,,,radicle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004586,"[""alevin""]",,A young fish; especially: a newly hatched salmon when still attached to the yolk sac.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000284,,,,,,,,A young fish; especially: a newly hatched salmon when still attached to the yolk sac.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004586,mgr,2010-04-12T11:02:54Z,,,,,BrendaTissueOBO,,BTO:0004586,,,,,,,,,,,,,,,,,,,alevin,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000092,"[""CXCL2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000092,,,,,,,,,,,,,,,,,,,,,,,,,,,,CXCL2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400447,"[""G subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400447,,,,,,,,,,,,,,,,,,,,,,,,,,,,G subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000170,"[""cambium""]",,"A thin formative layer between the xylem and phloem of most vascular plants that gives rise to new cells and is responsible for secondary growth; A lateral meristem in vascular plants, including the vascular cambium and cork cambium, that forms parallel rows of cells resulting in secondary tissues.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A thin formative layer between the xylem and phloem of most vascular plants that gives rise to new cells and is responsible for secondary growth; A lateral meristem in vascular plants, including the vascular cambium and cork cambium, that forms parallel rows of cells resulting in secondary tissues.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000170,,,,,,,BrendaTissueOBO,,BTO:0000170,,,,,,,,,,,,,,,,,,,cambium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217546,"[""VDR gene""]",,"This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Feb 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_00217466,,,,,,,,"This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Feb 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217546,,,,,,,,,,,,,,,,7421,VDR,NR1I1,,,,,,,,,,VDR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200344,"[""MST4 gene""]",,"The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400297,,,,,,,,"The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200344,,,,,,,,,,,,,,,,51765,MST4,MASK|MST4,,,,,,,,,,MST4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200399,"[""PDPK1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400307,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200399,,,,,,,,,,,,,,,,5170,PDPK1,PDK1,,,,,,,,,,PDPK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000711,"[""glioma cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0001531|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000711,,,,,,,BrendaTissueOBO,neuroglioma cell line,BTO:0000711,,,,,,,,,,,,,,,,,,,glioma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300118,"[""ACK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300118,,,,,,,,,,,,,,,,,,,,,,,,,,,,ACK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491004,"[""AK2 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491014,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491004,,,,,,,,,,,,,,,,,,,,,,,,,,,,AK2 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100445,"[""Raf proto-oncogene serine/threonine-protein kinase""]",,"A RAF proto-oncogene serine/threonine-protein kinase that is encoded in the genome of human. [PMID:20703093, PRO:KER] |RAF proto-oncogene serine/threonine-protein kinase (RAF1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300126,,,,,,,,"A RAF proto-oncogene serine/threonine-protein kinase that is encoded in the genome of human. [PMID:20703093, PRO:KER] |RAF proto-oncogene serine/threonine-protein kinase (RAF1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100445,,,,https://pharos.nih.gov/idg/targets/P04049,,,,,,,,,,,,,RAF1,RAF,,P04049,,,,,,,,Raf proto-oncogene serine/threonine-protein kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3674,"[""kidney rhabdoid cancer""]",,A embryonal cancer that is located in the kidney.,false,,,http://purl.obolibrary.org/obo/DOID_3672,,,,,,,,A embryonal cancer that is located in the kidney.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3674,,,,UMLS_CUI:C0854917|NCI:C8715,renal Rhabdoid tumor,,disease_ontology,kidney rhabdoid tumor,DOID:3674,,,,,,,,,,,,,,,,,,,kidney rhabdoid cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300589,"[""TRPM8 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300483,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300589,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPM8 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300213,"[""BUD32 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300213,,,,,,,,,,,,,,,,,,,,,,,,,,,,BUD32 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200169,"[""MASTL gene""]",,"This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Feb 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400160,,,,,,,,"This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Feb 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200169,,,,,,,,,,,,,,,,84930,MASTL,GW|GWL|THC2,,,,,,,,,,MASTL gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100530,"[""Serine/threonine-protein kinase tnni3k""]",,"A serine/threonine-protein kinase TNNI3K that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q59H18] |serine/threonine-protein kinase tnni3k (TNNI3K)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300320,,,,,,,,"A serine/threonine-protein kinase TNNI3K that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q59H18] |serine/threonine-protein kinase tnni3k (TNNI3K)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100530,,,,https://pharos.nih.gov/idg/targets/Q59H18,,,,,,,,,,,,,TNNI3K,CARK,,Q59H18,,,,,,,,Serine/threonine-protein kinase tnni3k,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200467,"[""SCYL2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400199,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200467,,,,,,,,,,,,,,,,55681,SCYL2,CVAK104|KIAA1360,,,,,,,,,,SCYL2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002222,"[""bract""]",,A small modified leaf in a flower cluster.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000713,,,,,,,,A small modified leaf in a flower cluster.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002222,,,,,,,BrendaTissueOBO,,BTO:0002222,,,,,,,,,,,,,,,,,,,bract,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80269,"[""Motilin""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG COMPOUND:C16047,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80269,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80269,,,,,Motilin,,CHEBI:80269,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100189,"[""12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor""]",,"A 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00270] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00270] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100189,,,,https://pharos.nih.gov/idg/targets/O00270,,,,,,,,,,,,,GPR31,,,O00270,,,,,,,,"12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001287,"[""sporangium""]",,A structure in which spores are produced.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001285,,,,,,,,A structure in which spores are produced.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001287,,,,,,,BrendaTissueOBO,,BTO:0001287,,,,,,,,,,,,,,,,,,,sporangium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200497,"[""STK16 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400115,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200497,,,,,,,,,,,,,,,,8576,STK16,MPSK1|PKL12|TSF1,,,,,,,,,,STK16 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200073,"[""CDK7 gene""]",,"The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400262,,,,,,,,"The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200073,,,,,,,,,,,,,,,,1022,CDK7,CAK|CAK1|CDKN7,,,,,,,,,,CDK7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200179,"[""GPR17 gene""]",,"A uracil nucleotide/cysteinyl leukotriene receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13304] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400033,,,,,,,,"A uracil nucleotide/cysteinyl leukotriene receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13304] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200179,,,,,,,,,,,,,,,,2840,GPR17,,,,,,,,,,,GPR17 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100376,"[""Obscurin""]",,"An obscurin that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5VST9] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300168,,,,,,,,"An obscurin that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5VST9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100376,,,,https://pharos.nih.gov/idg/targets/Q5VST9,,,,,,,,,,,,,OBSCN,KIAA1556|KIAA1639,,Q5VST9,,,,,,,,Obscurin,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400495,"[""Alpha-6/CHRNA6 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400495,,,,,,,,,,,,,,,,,,,,,,,,,,,,Alpha-6/CHRNA6 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004395,"[""microvessel""]",,"A blood vessel as a capillary, arteriole, or venule of the microcirculatory system.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001102,,,,,,,,"A blood vessel as a capillary, arteriole, or venule of the microcirculatory system.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004395,Marion,2010-01-29T03:21:57Z,,,,,BrendaTissueOBO,,BTO:0004395,,,,,,,,,,,,,,,,,,,microvessel,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100099,"[""Protein FAM26E""]",,"A protein FAM26E that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N5C1] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300347,,,,,,,,"A protein FAM26E that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N5C1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100099,,,,https://pharos.nih.gov/idg/targets/Q8N5C1,,,,,,,,,,,,,FAM26E,C6orf188,,Q8N5C1,,,,,,,,Protein FAM26E,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1441,"[""autosomal dominant cerebellar ataxia""]",,A hereditary ataxia that has_material_basis_in autosomal dominant inheritance.,false,,,http://purl.obolibrary.org/obo/DOID_0050951,,,,,,,,A hereditary ataxia that has_material_basis_in autosomal dominant inheritance.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1441,,,DOID:2478,UMLS_CUI:C0029534|MESH:D020754|ICD9CM:334.3|NCI:C82341|UMLS_CUI:C0087012|SNOMEDCT_US_2016_03_01:129609000,spinocerebellar ataxia ,,disease_ontology,,DOID:1441,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,autosomal dominant cerebellar ataxia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14418,"[""dracunculiasis""]",,"A parasitic helminthiasis infectious disease that involves parasitic infection by the larvae of the nematode Dracunculus medinensis, which are transmitted to humans by drinking water containing copepods infected with the larvae. The female, which contains larvae, burrows into the deeper connective tissues or adjacent to long bones or joints of the extremities. The worm emerges as a whitish filament in the center of a painful ulcer, accompanied by inflammation and frequently by secondary bacterial infection.",false,,,http://purl.obolibrary.org/obo/DOID_883,,,,,,,,"A parasitic helminthiasis infectious disease that involves parasitic infection by the larvae of the nematode Dracunculus medinensis, which are transmitted to humans by drinking water containing copepods infected with the larvae. The female, which contains larvae, burrows into the deeper connective tissues or adjacent to long bones or joints of the extremities. The worm emerges as a whitish filament in the center of a painful ulcer, accompanied by inflammation and frequently by secondary bacterial infection.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14418,,,,SNOMEDCT_US_2016_03_01:48874008|UMLS_CUI:C0013100|SNOMEDCT_US_2016_03_01:396334002|MESH:D004320|ICD9CM:125.7|ICD10CM:B72|NCI:C84677,Dracontiasis|Infection by Dracunculus medinensis (disorder)|Infection by Dracunculus medinensis,,disease_ontology,,DOID:14418,,,,,,,,,,,,,,,,,,,dracunculiasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10754,"[""otitis media""]",,A otitis which involves inflammation of the middle ear.,false,,,http://purl.obolibrary.org/obo/DOID_5100,,,,,,,,A otitis which involves inflammation of the middle ear.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10754,,,,MESH:D010033|NCI:C34885|SNOMEDCT_US_2016_03_01:194291009|ICD10CM:H66.90|SNOMEDCT_US_2016_03_01:267669008|SNOMEDCT_US_2016_03_01:155222006|ICD10CM:H66.9|ICD9CM:382.9|UMLS_CUI:C0029882|SNOMEDCT_US_2016_03_01:65363002,,,disease_ontology,,DOID:10754,,,,,,,,,,,,,,,,,,,otitis media,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003936,"[""laryngeal squamous cell carcinoma cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001289|http://purl.obolibrary.org/obo/BTO_0001625,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003936,,,,,,,BrendaTissueOBO,LSCC cell,BTO:0003936,,,,,,,,,,,,,,,,,,,laryngeal squamous cell carcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100128,"[""Glycine receptor subunit alpha-3""]",,"A glycine receptor subunit alpha-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75311] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300527,,,,,,,,"A glycine receptor subunit alpha-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75311] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100128,,,,https://pharos.nih.gov/idg/targets/O75311,,,,,,,,,,,,,GLRA3,,,O75311,,,,,,,,Glycine receptor subunit alpha-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200117,"[""DYRK4 gene""]",,"This gene encodes an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400267,,,,,,,,"This gene encodes an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200117,,,,,,,,,,,,,,,,8798,DYRK4,,,,,,,,,,,DYRK4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100031,"[""Beta-adrenergic receptor kinase 1""]",,"A beta-adrenergic receptor kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P25098] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300250,,,,,,,,"A beta-adrenergic receptor kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P25098] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100031,,,,https://pharos.nih.gov/idg/targets/P25098,,,,,,,,,,,,,ADRBK1,BARK|BARK1|GRK2,,P25098,,,,,,,,Beta-adrenergic receptor kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100205,"[""Probable G-protein coupled receptor 63""]",,"A G-protein coupled receptor 63 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BZJ6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 63 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BZJ6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100205,,,,https://pharos.nih.gov/idg/targets/Q9BZJ6,,,,,,,,,,,,,GPR63,PSP24B,,Q9BZJ6,,,,,,,,Probable G-protein coupled receptor 63,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400062,"[""Kisspeptin receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400062,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kisspeptin receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000072,"[""XCL2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000072,,,,,,,,,,,,,,,,,,,,,,,,,,,,XCL2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001808,"[""saphenous vein""]",,"Either of two main superficial veins of the leg, one larger than the other, that begin at the foot.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000234,,,,,,,,"Either of two main superficial veins of the leg, one larger than the other, that begin at the foot.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001808,,,,,,,BrendaTissueOBO,,BTO:0001808,,,,,,,,,,,,,,,,,,,saphenous vein,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100080,"[""Cyclin-dependent kinase-like 5""]",,"A cyclin-dependent kinase-like 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76039] |cyclin-dependent kinase-like 5 (CDKL5)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300138,,,,,,,,"A cyclin-dependent kinase-like 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76039] |cyclin-dependent kinase-like 5 (CDKL5)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100080,,,,https://pharos.nih.gov/idg/targets/O76039,,,,,,,,,,,,,CDKL5,STK9,,O76039,,,,,,,,Cyclin-dependent kinase-like 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8892,"[""pityriasis rosea""]",,,false,,,http://purl.obolibrary.org/obo/DOID_8893,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8892,,,,SNOMEDCT_US_2016_03_01:156373006|ICD9CM:696.3|MESH:D017515|NCI:C26855|ICD10CM:L42|SNOMEDCT_US_2016_03_01:77252004|UMLS_CUI:C0032026,Pityriasis circinata|Pityriasis rosea (disorder)|Pityriasis Rosea,,disease_ontology,,DOID:8892,,,,,,,,,,,,,,,,,,,pityriasis rosea,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4943,"[""adenocarcinoma in situ""]",,,false,,,http://purl.obolibrary.org/obo/DOID_8719,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4943,,,,NCI:C4123|UMLS_CUI:C0334276|SNOMEDCT_US_2016_03_01:51642000|MESH:D065311,,,disease_ontology,,DOID:4943,,,,,,,,,,,,,,,,,,,adenocarcinoma in situ,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1428,"[""endocrine pancreas disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_26,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1428,,,,SNOMEDCT_US_2016_03_01:267385007|SNOMEDCT_US_2016_03_01:190450004|SNOMEDCT_US_2016_03_01:237574003|ICD9CM:251|SNOMEDCT_US_2016_03_01:190427005|ICD10CM:E16|UMLS_CUI:C0154189,,,disease_ontology,,DOID:1428,,,,,,,,,,,,,,,,,,,endocrine pancreas disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_14284,"[""patellofemoral pain syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_381,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:14284,,,,UMLS_CUI:C0877149|MESH:D046788,,,disease_ontology,,DOID:14284,,,,,,,,,,,,,,,,,,,patellofemoral pain syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1570,"[""ectropion""]",,,false,,,http://purl.obolibrary.org/obo/DOID_530,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1570,,,,ICD10CM:H02.109|MESH:D004483|ICD9CM:374.1|SNOMEDCT_US_2016_03_01:193934003|UMLS_CUI:C0013592|ICD10CM:H02.10|SNOMEDCT_US_2016_03_01:193935002|ICD9CM:374.10|SNOMEDCT_US_2016_03_01:155178000|SNOMEDCT_US_2016_03_01:127559009|SNOMEDCT_US_2016_03_01:62909004|ICD10CM:H02.1,Everted margin|Ectropion of eyelid,,disease_ontology,,DOID:1570,,,,,,,,,,,,,,,,,,,ectropion,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3891,"[""placental insufficiency""]",,A placenta disease that is characterized by insufficient blood flow to the placenta during pregnancy.,false,,,http://purl.obolibrary.org/obo/DOID_780,,,,,,,,A placenta disease that is characterized by insufficient blood flow to the placenta during pregnancy.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3891,,,,SNOMEDCT_US_2016_03_01:267337006|SNOMEDCT_US_2016_03_01:199610002|UMLS_CUI:C0032051|MESH:D010927|SNOMEDCT_US_2016_03_01:156185006|SNOMEDCT_US_2016_03_01:237292005,,,disease_ontology,,DOID:3891,,,,,,,,,,,,,,,,,,,placental insufficiency,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200519,"[""OR2C3 gene""]",,"An olfactory receptor 2C3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N628] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2C3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N628] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200519,,,,,,,,,,,,,,,,81472,OR2C3,OR2C4|OR2C5P,,,,,,,,,,OR2C3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000958,"[""spermatogonium""]",,"An undifferentiated germ cell of a male, originating in a seminiferous tubule and dividing into two primary spermatocytes.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000535,,,,,,,,"An undifferentiated germ cell of a male, originating in a seminiferous tubule and dividing into two primary spermatocytes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000958,,,,,,,BrendaTissueOBO,spermatospore|spermatophore|spermospore,BTO:0000958,,,,,,,,,,,,,,,,,,,spermatogonium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100829,"[""Putative vomeronasal receptor-like protein 4""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300016,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100829,,,,https://pharos.nih.gov/idg/targets/Q8TDU5,,,,,,,,,,,,,VN1R17P,VNRL4,,Q8TDU5,,,,,,,,Putative vomeronasal receptor-like protein 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10629,"[""microphthalmia""]",,An eye disease where one or both eyeballs are abnormally small.,false,,,http://purl.obolibrary.org/obo/DOID_5614,,,,,,,,An eye disease where one or both eyeballs are abnormally small.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10629,,,DOID:10650,OMIM:610125|NCI:C98989|OMIM:609549|OMIM:600165|OMIM:611040|UMLS_CUI:C0026010|OMIM:309801|OMIM:610093|SNOMEDCT_US_2016_03_01:268310007|OMIM:601186|OMIM:613704|OMIM:300166|ICD9CM:743.10|OMIM:607932|ORDO:35612|OMIM:613094|SNOMEDCT_US_2016_03_01:61142002|MESH:D008850|OMIM:611897|ICD9CM:743.11|OMIM:206900|ICD9CM:743.1|SNOMEDCT_US_2016_03_01:204110003|OMIM:611038|SNOMEDCT_US_2016_03_01:204107005|SNOMEDCT_US_2016_03_01:204104003|OMIM:615972|ICD10CM:Q11.2|SNOMEDCT_US_2016_03_01:204108000|SNOMEDCT_US_2016_03_01:156902006,simple microphthalmos|microphthalmos|nanophthalmia|nanophthalmos,,disease_ontology,,DOID:10629,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,microphthalmia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200544,"[""OR2S2 gene""]",,"An olfactory receptor 2S2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NQN1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2S2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NQN1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200544,,,,,,,,,,,,,,,,56656,OR2S2,,,,,,,,,,,OR2S2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100056,"[""C-C chemokine receptor type 4""]",,"A C-C chemokine receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51679] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300095,,,,,,,,"A C-C chemokine receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51679] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100056,,,,https://pharos.nih.gov/idg/targets/P51679,,,,,,,,,,,,,CCR4,CMKBR4,,P51679,,,,,,,,C-C chemokine receptor type 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001863,"[""body wall muscle""]",,A worm's body wall has two kinds of muscles that it uses to crawl. Circular muscles surround the worm's body and can make the body shrink or spread out. Longitudinal muscles run the length of the body and can shorten or lengthen the worm. Setae (bristles) prevent the worm from slipping.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0002385|http://purl.obolibrary.org/obo/BTO_0000887,,,,,,,,A worm's body wall has two kinds of muscles that it uses to crawl. Circular muscles surround the worm's body and can make the body shrink or spread out. Longitudinal muscles run the length of the body and can shorten or lengthen the worm. Setae (bristles) prevent the worm from slipping.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001863,,,,,,,BrendaTissueOBO,wall muscle,BTO:0001863,,,,,,,,,,,,,,,,,,,body wall muscle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100540,"[""Testis-specific serine/threonine-protein kinase 1""]",,"A testis-specific serine/threonine-protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BXA7] |testis-specific serine/threonine-protein kinase 1 (TSSK1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300238,,,,,,,,"A testis-specific serine/threonine-protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BXA7] |testis-specific serine/threonine-protein kinase 1 (TSSK1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100540,,,,https://pharos.nih.gov/idg/targets/Q9BXA7,,,,,,,,,,,,,TSSK1B,SPOGA1|SPOGA4|STK22A|STK22D|TSSK1,,Q9BXA7,,,,,,,,Testis-specific serine/threonine-protein kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100631,"[""6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2""]",,"A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60825] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300325,,,,,,,,"A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60825] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100631,,,,https://pharos.nih.gov/idg/targets/O60825,,,,,,,,,,,,,PFKFB2,,,O60825,,,,,,,,"6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200786,"[""TAS2R40 gene""]",,"A taste receptor type 2 member 40 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59535] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400014,,,,,,,,"A taste receptor type 2 member 40 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59535] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200786,,,,,,,,,,,,,,,,259286,TAS2R40,GPR60,,,,,,,,,,TAS2R40 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200055,"[""CDK11B gene""]",,"This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400254,,,,,,,,"This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200055,,,,,,,,,,,,,,,,984,CDK11B,CDC2L1|CDK11|PITSLREA,,,,,,,,,,CDK11B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000035,"[""AKT1 kinase domain""]",,V-akt murine thymoma viral oncogene homolog 1; AKT; AKT1; Akt1/PKBa; MGC99656; PKB; PKBa; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,V-akt murine thymoma viral oncogene homolog 1; AKT; AKT1; Akt1/PKBa; MGC99656; PKB; PKBa; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000035,,,,,,,,,,,,,,,,,,,200034,,,,,,,,,AKT1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000222,"[""myoblast""]",,An embryonic cell that becomes a cell of muscle fiber.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,An embryonic cell that becomes a cell of muscle fiber.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000222,,,,,,,BrendaTissueOBO,sarcoblast,BTO:0000222,,,,,,,,,,,,,,,,,,,myoblast,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000310,"[""NEK10 kinase domain""]",,NIMA (never in mitosis gene a)- related kinase 10,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,NIMA (never in mitosis gene a)- related kinase 10,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000310,,,,,,,,,,,,,,,,,,,200481,,,,,,,,,NEK10 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3713,"[""ovary adenocarcinoma""]",,An ovarian carcinoma that derives_from epithelial cells of glandular origin.,false,,,http://purl.obolibrary.org/obo/DOID_4001|http://purl.obolibrary.org/obo/DOID_299,,,,,,,,An ovarian carcinoma that derives_from epithelial cells of glandular origin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3713,,,DOID:7816,NCI:C7700|UMLS_CUI:C0948216,ovarian adenoacanthoma|Ovarian adenocarcinoma,,disease_ontology,adenocarcinoma of the ovary,DOID:3713,,,,,,,,,,,,,,,,,,,ovary adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100152,"[""Probable g-protein coupled receptor 149""]",,"A G-protein coupled receptor 149 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86SP6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 149 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86SP6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100152,,,,https://pharos.nih.gov/idg/targets/Q86SP6,,,,,,,,,,,,,GPR149,PGR10,,Q86SP6,,,,,,,,Probable g-protein coupled receptor 149,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200186,"[""KCNA7 gene""]",,"Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. The gene is expressed preferentially in skeletal muscle, heart and kidney. It is a candidate gene for inherited cardiac disorders. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400538,,,,,,,,"Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. The gene is expressed preferentially in skeletal muscle, heart and kidney. It is a candidate gene for inherited cardiac disorders. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200186,,,,,,,,,,,,,,,,3743,KCNA7,,,,,,,,,,,KCNA7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200081,"[""DRD1 gene""]",,"A D(1A) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21728] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400037,,,,,,,,"A D(1A) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21728] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200081,,,,,,,,,,,,,,,,1812,DRD1,,,,,,,,,,,DRD1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8618,"[""oral cavity cancer""]",,A gastrointestinal system cancer that is located_in the oral cavity.,false,,,http://purl.obolibrary.org/obo/DOID_3119,,,,,,,,A gastrointestinal system cancer that is located_in the oral cavity.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8618,,,DOID:0050627|DOID:8617|DOID:9055|DOID:9049,SNOMEDCT_US_2016_03_01:363385007|ICD9CM:144.1|ICD9CM:144.9|NCI:C9318|ICD10CM:C04.1|ICD9CM:144|ICD10CM:C04.0|SNOMEDCT_US_2016_03_01:187653008|UMLS_CUI:C0153369|UMLS_CUI:C0496758|SNOMEDCT_US_2016_03_01:93802007|UMLS_CUI:C0153368|SNOMEDCT_US_2016_03_01:187652003|ICD10CM:C04|ICD10CM:C04.9|SNOMEDCT_US_2016_03_01:93672006|SNOMEDCT_US_2016_03_01:187656000|SNOMEDCT_US_2016_03_01:93860002|ICD9CM:144.0,malignant tumor of anterior floor of mouth (disorder)|malignant neoplasm of lateral portion of floor of mouth|malignant neoplasm of lateral floor of mouth|malignant tumor of the Floor of the Mouth|malignant neoplasm of anterior portion of floor of mouth|malignant neoplasm of floor of mouth|malignant tumor of lateral floor of mouth (disorder),,disease_ontology,,DOID:8618,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,oral cavity cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000058,"[""BTK kinase domain""]",,Tyrosine-protein kinase BTK; agammaglobulinemia tyrosine kinase; AGMX1; ATK; BPK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Tyrosine-protein kinase BTK; agammaglobulinemia tyrosine kinase; AGMX1; ATK; BPK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000058,,,,,,,,,,,,,,,,,,,200059,,,,,,,,,BTK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000110,"[""MET121 in VRK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000110,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET121 in VRK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100500,"[""Serine/threonine-protein kinase 31""]",,"A serine/threonine-protein kinase 31 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BXU1] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300218,,,,,,,,"A serine/threonine-protein kinase 31 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BXU1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100500,,,,https://pharos.nih.gov/idg/targets/Q9BXU1,,,,,,,,,,,,,STK31,SGK396,,Q9BXU1,,,,,,,,Serine/threonine-protein kinase 31,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200436,"[""OR52W1 gene""]",,"An olfactory receptor 52W1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF63] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 52W1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF63] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200436,,,,,,,,,,,,,,,,120787,OR52W1,OR52W1P,,,,,,,,,,OR52W1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200185,"[""INSRR gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400163,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200185,,,,,,,,,,,,,,,,3645,INSRR,IRR,,,,,,,,,,INSRR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000159,"[""MET315 in STK35""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000159,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET315 in STK35,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100193,"[""Potassium voltage-gated channel subfamily D member 1""]",,"A voltage-gated potassium channel KCND1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9NSA2] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300545,,,,,,,,"A voltage-gated potassium channel KCND1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9NSA2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100193,,,,https://pharos.nih.gov/idg/targets/Q9NSA2,,,,,,,,,,,,,KCND1,,,Q9NSA2,,,,,,,,Potassium voltage-gated channel subfamily D member 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200191,"[""KCNC3 gene""]",,"The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Alternate splicing results in several transcript variants. [provided by RefSeq, Mar 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_01400543,,,,,,,,"The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Alternate splicing results in several transcript variants. [provided by RefSeq, Mar 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200191,,,,,,,,,,,,,,,,3748,KCNC3,,,,,,,,,,,KCNC3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3119,"[""gastrointestinal system cancer""]",,An organ system cancer located_in gastrointestinal tract that is manifested in organs of the gastrointestinal system.,false,,,http://purl.obolibrary.org/obo/DOID_0050686|http://purl.obolibrary.org/obo/DOID_77,,,,,,,,An organ system cancer located_in gastrointestinal tract that is manifested in organs of the gastrointestinal system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3119,,,DOID:8377|DOID:4945,ICD9CM:239.0|UMLS_CUI:C0017185|SNOMEDCT_US_2016_03_01:367543008|NCI:C4890|MESH:D005770|SNOMEDCT_US_2016_03_01:276806006|SNOMEDCT_US_2016_03_01:126768004|SNOMEDCT_US_2016_03_01:128415001|SNOMEDCT_US_2016_03_01:189527000|ICD10CM:C26.9|SNOMEDCT_US_2016_03_01:428905002|UMLS_CUI:C0685938|MESH:D004067|NCI:C3052|SNOMEDCT_US_2016_03_01:93811007|UMLS_CUI:C0012243|SNOMEDCT_US_2016_03_01:128348002,GI tumor|digestive system cancer|gastrointestinal tract cancer,,disease_ontology,,DOID:3119,http://purl.obolibrary.org/obo/doid#DO_MGI_slim|http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,gastrointestinal system cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1080,"[""filariasis""]",,A parasitic helminthiasis infectious disease that involves parasitic infection of the lymphatics and subcutaneous tissue by nematodes of the superfamily Filarioidea.,false,,,http://purl.obolibrary.org/obo/DOID_883,,,,,,,,A parasitic helminthiasis infectious disease that involves parasitic infection of the lymphatics and subcutaneous tissue by nematodes of the superfamily Filarioidea.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1080,,,,ICD10CM:B74|SNOMEDCT_US_2016_03_01:50342004|ICD10CM:B74.9|SNOMEDCT_US_2016_03_01:105706003|ICD9CM:125.9|MESH:D005368|SNOMEDCT_US_2016_03_01:187532008|SNOMEDCT_US_2016_03_01:187161002|NCI:C34611|UMLS_CUI:C0016085,disease due to superfamily Filarioidea (disorder),,disease_ontology,,DOID:1080,,,,,,,,,,,,,,,,,,,filariasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10808,"[""gastric ulcer""]",,,false,,,http://purl.obolibrary.org/obo/DOID_750,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10808,,,DOID:241|DOID:13125|DOID:12806|DOID:12069|DOID:13124|DOID:242|DOID:12047|DOID:12068|DOID:10807|DOID:10809|DOID:12057,UMLS_CUI:C0038358|SNOMEDCT_US_2016_03_01:196649003|ICD9CM:531|MESH:D013276|SNOMEDCT_US_2016_03_01:266436006|SNOMEDCT_US_2016_03_01:155681009|SNOMEDCT_US_2016_03_01:155690002|NCI:C3388|ICD10CM:K25|SNOMEDCT_US_2016_03_01:196627009|SNOMEDCT_US_2016_03_01:196642007|SNOMEDCT_US_2016_03_01:397825006|SNOMEDCT_US_2016_03_01:196650003|SNOMEDCT_US_2016_03_01:6034002,"acute gastric ulcer with haemorrhage and perforation|chronic gastric ulcer without mention of hemorrhage or perforation, with obstruction|bleeding acute gastric ulcer|acute gastric ulcer with perforation AND obstruction|chronic gastric ulcer without hemorrhage AND without perforation but with obstruction|chronic gastric ulcer without hemorrhage AND without perforation but with obstruction (disorder)|acute gastric ulcer with hemorrhage and perforation|acute gastric ulcer with perforation AND obstruction (disorder)|acute gastric ulcer without hemorrhage, without perforation AND without obstruction (disorder)|acute gastric ulcer with hemorrhage AND obstruction (disorder)|acute gastric ulcer with hemorrhage, with perforation AND with obstruction (disorder)|acute gastric ulcer with hemorrhage and perforation, without mention of obstruction|acute gastric ulcer with hemorrhage, with obstruction|acute gastric ulcer without hemorrhage, without perforation AND without obstruction|acute gastric ulcer with hemorrhage AND with perforation but without obstruction (disorder)|acute gastric ulcer with hemorrhage and obstruction|acute gastric ulcer with hemorrhage AND perforation [dup] (disorder)|acute gastric ulcer without mention of hemorrhage or perforation, without mention of obstruction|acute gastric ulcer with perforation|acute gastric ulcer with hemorrhage AND with perforation but without obstruction|acute gastric ulcer with hemorrhage AND perforation (disorder)|acute gastric ulcer without hemorrhage and without perforation|acute gastric ulcer with perforation, with obstruction|acute gastric ulcer with hemorrhage and perforation, with obstruction|chronic gastric ulcer without hemorrhage AND without perforation|acute gastric ulcer with hemorrhage AND perforation",,disease_ontology,,DOID:10808,,,,,,,,,,,,,,,,,,,gastric ulcer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300413,"[""GRIA4 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300413,,,,,,,,,,,,,,,,,,,,,,,,,,,,GRIA4 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300326,"[""Nucleotide kinase""]",,A Nucleotide kinase is a kinase enzyme that catalyzes the phosphorylation of a nucleotide substrate.,false,,,http://www.drugtargetontology.org/dto/DTO_03300103,,,,,,,,A Nucleotide kinase is a kinase enzyme that catalyzes the phosphorylation of a nucleotide substrate.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300326,,,,,,,,,,,,,,,,,,,,,,,,,,,,Nucleotide kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003064,"[""Mueller cell""]",,"Mueller cells are astrocyte-like radial glial cells that extend vertically throughout the retina, although their nuclei are usually in the middle of the inner nuclear layer.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Mueller cells are astrocyte-like radial glial cells that extend vertically throughout the retina, although their nuclei are usually in the middle of the inner nuclear layer.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003064,,,,,,,BrendaTissueOBO,Muller cell,BTO:0003064,,,,,,,,,,,,,,,,,,,Mueller cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100198,"[""Probable G-protein coupled receptor 45""]",,"A G-protein coupled receptor 45 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5Y3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 45 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5Y3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100198,,,,https://pharos.nih.gov/idg/targets/Q9Y5Y3,,,,,,,,,,,,,GPR45,,,Q9Y5Y3,,,,,,,,Probable G-protein coupled receptor 45,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100073,"[""Cyclin-dependent kinase 7""]",,A cell division protein kinase 7 that is encoded in the genome of human. |cyclin-dependent kinase 7 (CDK7)  with  no mutation  in a nonphosphorylated state,false,,,http://www.drugtargetontology.org/dto/DTO_03300262,,,,,,,,A cell division protein kinase 7 that is encoded in the genome of human. |cyclin-dependent kinase 7 (CDK7)  with  no mutation  in a nonphosphorylated state,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100073,,,,https://pharos.nih.gov/idg/targets/P50613,,,,,,,,,,,,,CDK7,CAK|CAK1|CDKN7|MO15|STK1,,P50613,,,,,,,,Cyclin-dependent kinase 7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300580,"[""TRPC5 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300482,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300580,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPC5 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200538,"[""OR2L13 gene""]",,"An olfactory receptor 2L13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N349] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2L13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N349] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200538,,,,,,,,,,,,,,,,284521,OR2L13,OR2L14,,,,,,,,,,OR2L13 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000355,"[""THR421 in RAF1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000355,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR421 in RAF1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100125,"[""Gonadotropin-releasing hormone receptor""]",,"A gonadotropin-releasing hormone I receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30968] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300050,,,,,,,,"A gonadotropin-releasing hormone I receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30968] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100125,,,,https://pharos.nih.gov/idg/targets/P30968,,,,,,,,,,,,,GNRHR,GRHR,,P30968,,,,,,,,Gonadotropin-releasing hormone receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_30013,"[""L-threonine residue""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_33700,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:30013,,,,RESID:AA0017,L-threonine residue,,chebi_ontology,-Thr-|L-threonyl|101.048|L-threonine|T|Thr|C4H7NO2|0|101.10392,CHEBI:30013,http://purl.obolibrary.org/obo/chebi#3_STAR,,,,,,,,,,,,,,,,,,L-threonine residue,,,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300437,"[""Calcium-activated subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300437,,,,,,,,,,,,,,,,,,,,,,,,,,,,Calcium-activated subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000153,"[""MET229 in AKT2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000153,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET229 in AKT2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200776,"[""TAS2R10 gene""]",,"A taste receptor type 2 member 10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400014,,,,,,,,"A taste receptor type 2 member 10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200776,,,,,,,,,,,,,,,,50839,TAS2R10,,,,,,,,,,,TAS2R10 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003372,"[""gametophore""]",,"A structure, as in liverworts and mosses, on which gametangia are borne.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A structure, as in liverworts and mosses, on which gametangia are borne.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003372,,,,,,,BrendaTissueOBO,,BTO:0003372,,,,,,,,,,,,,,,,,,,gametophore,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002045,"[""capillary""]",,A capillary tube; especially: any of the smallest blood vessels connecting arterioles with venules and forming networks throughout the body.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001102,,,,,,,,A capillary tube; especially: any of the smallest blood vessels connecting arterioles with venules and forming networks throughout the body.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002045,,,,,,,BrendaTissueOBO,,BTO:0002045,,,,,,,,,,,,,,,,,,,capillary,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000233,"[""LATS2 kinase domain""]",,"LATS, large tumor suppressor, homolog 2 (Drosophila); FLJ13161; KPM; LATS2",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"LATS, large tumor suppressor, homolog 2 (Drosophila); FLJ13161; KPM; LATS2",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000233,,,,,,,,,,,,,,,,,,,200223,,,,,,,,,LATS2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200133,"[""GRIA1 gene""]",,"Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400410,,,,,,,,"Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200133,,,,,,,,,,,,,,,,2890,GRIA1,GLUH1|GLUR1,,,,,,,,,,GRIA1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_7596,"[""asbestos-related lung carcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3905,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:7596,,,,NCI:C27925|UMLS_CUI:C1332337,,,disease_ontology,,DOID:7596,,,,,,,,,,,,,,,,,,,asbestos-related lung carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2661,"[""myoepithelioma""]",,A sweat gland neoplasm that is composed_of outgrowths of myoepithelial cells from a sweat gland.,false,,,http://purl.obolibrary.org/obo/DOID_2664,,,,,,,,A sweat gland neoplasm that is composed_of outgrowths of myoepithelial cells from a sweat gland.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2661,,,,SNOMEDCT_US_2016_03_01:69291002|NCI:C40392|UMLS_CUI:C0027070|MESH:D009208,Myoepithelial neoplasm|Myoepithelial adenoma|benign myoepithelioma,,disease_ontology,,DOID:2661,,,,,,,,,,,,,,,,,,,myoepithelioma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200478,"[""OR1A2 gene""]",,"An olfactory receptor 1A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y585] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y585] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200478,,,,,,,,,,,,,,,,26189,OR1A2,,,,,,,,,,,OR1A2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004217,"[""SK-N-DZ cell""]",,Neuroblastoma cell line derived in 1978 from a bone marrow metastasis from a 2 years old caucasian female child with poorly differentiated embryonal neuroblastoma.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000932,,,,,,,,Neuroblastoma cell line derived in 1978 from a bone marrow metastasis from a 2 years old caucasian female child with poorly differentiated embryonal neuroblastoma.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004217,,,,,,,BrendaTissueOBO,,BTO:0004217,,,,,,,,,,,,,,,,,,,SK-N-DZ cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002595,"[""leiomyosarcoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000400,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002595,,,,,,,BrendaTissueOBO,,BTO:0002595,,,,,,,,,,,,,,,,,,,leiomyosarcoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002022,"[""bronchial epithelial cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0000353|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002637,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002022,,,,,,,BrendaTissueOBO,BEC cell|bronchial epithelium cell line,BTO:0002022,,,,,,,,,,,,,,,,,,,bronchial epithelial cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001976,"[""Neuro-2a cell""]",,Mus musculus (mouse) brain neuroblastoma cell line. Clone Neuro-2a was established by R.J. Klebe and F.H. Ruddle from a spontaneous tumor of a strain A albino mouse.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000932,,,,,,,,Mus musculus (mouse) brain neuroblastoma cell line. Clone Neuro-2a was established by R.J. Klebe and F.H. Ruddle from a spontaneous tumor of a strain A albino mouse.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001976,,,,,,,BrendaTissueOBO,N-2a cell|NEURO-2A cell|Neuro2A cell|NB-2a cell|N2a cell|NB2a cell|Nb2a cell|N2alpha cell,BTO:0001976,,,,,,,,,,,,,,,,,,,Neuro-2a cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100106,"[""Putative fxyd domain-containing ion transport regulator 8""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300348,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100106,,,,https://pharos.nih.gov/idg/targets/P58550,,,,,,,,,,,,,FXYD6P3,FXYD8,,P58550,,,,,,,,Putative fxyd domain-containing ion transport regulator 8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003029,"[""SKLU-1 cell""]",,Non-small cell lung cancer cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002553,,,,,,,,Non-small cell lung cancer cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003029,,,,,,,BrendaTissueOBO,SK-LU-1 cell|SK LU 1 cell|SKLU1 cell,BTO:0003029,,,,,,,,,,,,,,,,,,,SKLU-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000012,"[""GLN128 in SBK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30011,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000012,,,,,,,,,,,,,,,,,,,,,,,,,,,,GLN128 in SBK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000257,"[""uterine cancer cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000257,,,,,,,BrendaTissueOBO,,BTO:0000257,,,,,,,,,,,,,,,,,,,uterine cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200163,"[""GPR171 gene""]",,"A G-protein coupled receptor 171 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14626] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400053,,,,,,,,"A G-protein coupled receptor 171 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14626] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200163,,,,,,,,,,,,,,,,29909,GPR171,H963,,,,,,,,,,GPR171 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200334,"[""MAP2K1 gene""]",,"The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400194,,,,,,,,"The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200334,,,,,,,,,,,,,,,,5604,MAP2K1,MEK1|PRKMK1,,,,,,,,,,MAP2K1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000189,"[""MET604 in NEK10""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000189,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET604 in NEK10,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/UBERON_0002107,"[""liver""]",jecur|iecur,"An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO].",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000345|http://purl.obolibrary.org/obo/BTO_0001491|http://purl.obolibrary.org/obo/UBERON_0001062,,relationship type change: differentiates_from endoderm (AAO:0000139) CHANGED TO: develops_from endoderm (UBERON:0000925)[AAO],,,,,http://www.snomedbrowser.com/Codes/Details/181268008|http://linkedlifedata.com/resource/umls/id/C0023884|http://en.wikipedia.org/wiki/Liver|VHOG:0000257|MIAA:0000097|GAID:288|EFO:0000887|BTO:0000759|OpenCyc:Mx4rvVimppwpEbGdrcN5Y29ycA|ncithesaurus:Liver|galen:Liver|EV:0100089|FMA:7197|MESH:A03.620|MA:0000358|ZFA:0000123|TAO:0000123|UMLS:C0023884|XAO:0000133|EHDAA:2197|EHDAA2:0000997|EMAPA:16846|MAT:0000097|AAO:0010111|CALOHA:TS-0564,"An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO].",,http://upload.wikimedia.org/wikipedia/commons/thumb/6/64/Leber_Schaf.jpg/200px-Leber_Schaf.jpg|http://upload.wikimedia.org/wikipedia/commons/6/64/Leber_Schaf.jpg,,,,,,,,Organ which secretes bile and participates in formation of certain blood proteins.[AAO],,,,,,,,,,,,,,,,,,,,,,,,,,,,uberon,jecur|iecur,hepatic,"All vertebrates possess a liver (reference 1); Later in craniate evolution, an anterior gill arch was transformed into jaws, and many new types of feeding subsequently evolved.(...) A liver evolved that, among its many functions, stores considerable energy as glycogen or lipid (reference 2).[well established][VHOG]",,,,,,,,,,,,,,,,,,,,,,,,UBERON:0002107,,,"AO notes: Only ZFA considers this part_of immune system - we weaken this to an overlaps relation, as in general it's only a subset of cells that have clear immune function. Taxon notes: WP: The liver is found in all vertebrates, and is typically the largest visceral organ. Its form varies considerably in different species, and is largely determined by the shape and arrangement of the surrounding organs. Nonetheless, in most species it is divided into right and left lobes; exceptions to this general rule include snakes, where the shape of the body necessitates a simple cigar-like form. The internal structure of the liver is broadly similar in all vertebrates.[7] An organ sometimes referred to as a liver is found associated with the digestive tract of the primitive chordate Amphioxus. However, this is an enzyme secreting gland, not a metabolic organ, and it is unclear how truly homologous it is to the vertebrate liver. //  The zebrafish liver differs from the mammalian liver in that the hepatocytes are not clearly organized in cords or lobules and the typical portal triads are not apparent. In addition, the zebrafish liver does not have Kuppfer cells. Furthermore, a clear distinction can be made between the male and female liver in the adult zebrafish. The female hepatocytes are very basophilic (Figure 15c) as a result of the production of vitellogenin (Van der Ven et al. 2003).",,liver,,UBERON:0002107,,http://purl.obolibrary.org/obo/uberon.owl,http://purl.obolibrary.org/obo/uberon/core#efo_slim|http://purl.obolibrary.org/obo/uberon/core#organ_slim|http://purl.obolibrary.org/obo/uberon/core#vertebrate_core|http://purl.obolibrary.org/obo/uberon/core#major_organ|http://purl.obolibrary.org/obo/uberon/core#uberon_slim,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400317,"[""MST subfamily> gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400187,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400317,,,,,,,,,,,,,,,,,,,,,,,,,,,,MST subfamily> gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200067,"[""CLCA3P gene""]",,"This gene is a transcribed pseudogene belonging to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. This gene contains several nonsense codons compared to other family members that render the transcript a candidate for nonsense-mediated mRNA decay (NMD). Therefore, this gene is unlikely to be protein-coding. [provided by RefSeq, Jan 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400339,,,,,,,,"This gene is a transcribed pseudogene belonging to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. This gene contains several nonsense codons compared to other family members that render the transcript a candidate for nonsense-mediated mRNA decay (NMD). Therefore, this gene is unlikely to be protein-coding. [provided by RefSeq, Jan 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200067,,,,,,,,,,,,,,,,9629,CLCA3P,CLCA3,,,,,,,,,,CLCA3P gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117484,"[""Retinoic acid receptor gamma""]",,"A retinoic acid receptor gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P13631] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117461,,,,,,,,"A retinoic acid receptor gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P13631] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117484,,,,https://pharos.nih.gov/idg/targets/P13631,,,,,,,,,,,,,RARG,,,P13631,,,,,,,,Retinoic acid receptor gamma,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000251,"[""MAP3K1 kinase domain""]",,Mitogen-activated protein kinase kinase kinase 1; MAP3K1; MAPKKK1; MEKK; MEKK1; MEKK1/MAP3K1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase kinase kinase 1; MAP3K1; MAPKKK1; MEKK; MEKK1; MEKK1/MAP3K1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000251,,,,,,,,,,,,,,,,,,,200235,,,,,,,,,MAP3K1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001409,"[""ureter""]",,The tube that carries urine from the kidney to the bladder.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,,The tube that carries urine from the kidney to the bladder.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001409,,,,,,,BrendaTissueOBO,,BTO:0001409,,,,,,,,,,,,,,,,,,,ureter,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000361,"[""PKAC-alpha kinase domain""]",,"Protein kinase, cAMP-dependent, catalytic, alpha; MGC102831; MGC48865; PKAa; PKACA; PKAC-a; PKACalpha; PKAC-alpha; PRKACA",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Protein kinase, cAMP-dependent, catalytic, alpha; MGC102831; MGC48865; PKAa; PKACA; PKAC-a; PKACalpha; PKAC-alpha; PRKACA",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000361,,,,,,,,,,,,,,,,,,,200344,,,,,,,,,PKAC-alpha kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100580,"[""FGGY carbohydrate kinase domain-containing protein""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100580,,,,,,,,,,,,,,,,,FGGY,,,Q96C11,,,,,,,,FGGY carbohydrate kinase domain-containing protein,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060379,"[""acrofacial dysostosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1934,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060379,elvira,2015-09-21T15:24:28Z,,,,,disease_ontology,,DOID:0060379,,,,,,,,,,,,,,,,,,,acrofacial dysostosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060372,"[""autosomal recessive early-onset Parkinson disease 15""]",,A Parkinson's disease that has_material_basis_in mutation in the FBXO7 gene on chromosome 22q12.3.,false,,,http://purl.obolibrary.org/obo/DOID_0060894,,,,,,,,A Parkinson's disease that has_material_basis_in mutation in the FBXO7 gene on chromosome 22q12.3.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060372,elvira,2015-09-17T17:13:37Z,,OMIM:260300|ORDO:171695,Parkinsonian-pyramidal syndrome|pallidopyramidal syndrome,,disease_ontology,,DOID:0060372,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,autosomal recessive early-onset Parkinson disease 15,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001387,"[""tonsil""]",,"The human palatine tonsils and the nasopharyngeal tonsil are lymphoepithelial tissues located in strategic areas of the oropharynx and nasopharynx, although most commonly, the term tonsils refers to the palatine tonsils that can be seen in the back of the throat.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000753,,,,,,,,"The human palatine tonsils and the nasopharyngeal tonsil are lymphoepithelial tissues located in strategic areas of the oropharynx and nasopharynx, although most commonly, the term tonsils refers to the palatine tonsils that can be seen in the back of the throat.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001387,,,,,,,BrendaTissueOBO,Mandel,BTO:0001387,,,,,,,,,,,,,,,,,,,tonsil,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200248,"[""LRRC55 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200248,,,,,,,,,,,,,,,,,LRRC55,,,,,,,,,,,LRRC55 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400369,"[""Sodium channel family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400369,,,,,,,,,,,,,,,,,,,,,,,,,,,,Sodium channel family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200180,"[""KCNA1 gene""]",,"This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400532,,,,,,,,"This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200180,,,,,,,,,,,,,,,,3736,KCNA1,,,,,,,,,,,KCNA1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_15650,"[""leukotriene E4""]","(7E,9E,11Z,14Z)-(5S,6R)-6-(Cystein-S-yl)-5-hydroxyeicosa-7,9,11,14-tetraenoate|439.239|LTE4|OTZRAYGBFWZKMX-FRFVZSDQSA-N|439.60900|(5S-(5R*,6S*(S*),7E,9E,11Z,14Z))-6-((2-Amino-2-carboxyethyl)thio)-5-hydroxy-7,9,11,14-eicosatetraenoic acid|CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](N)C(O)=O)[C@@H](O)CCCC(O)=O|5S-hydroxy,6R-(S-cysteinyl),7E,9E,11Z,14Z-eicosatetraenoic acid|(7E,9E,11Z,14Z)-(5S,6R)-6-(Cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate|C23H37NO5S|0|InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1",,false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,LIPID_MAPS_instance:LMFA03020002|KEGG:C05952|CAS:75715-89-8|PMID:19291727,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:18612|CHEBI:10936|CHEBI:6424|CHEBI:261|CHEBI:25027,,"(5S,6R,7E,9E,11Z,14Z)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoic acid|S-{(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl}-L-cysteine|Leukotriene E4",,chebi_ontology,"(7E,9E,11Z,14Z)-(5S,6R)-6-(Cystein-S-yl)-5-hydroxyeicosa-7,9,11,14-tetraenoate|439.239|LTE4|OTZRAYGBFWZKMX-FRFVZSDQSA-N|439.60900|(5S-(5R*,6S*(S*),7E,9E,11Z,14Z))-6-((2-Amino-2-carboxyethyl)thio)-5-hydroxy-7,9,11,14-eicosatetraenoic acid|CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](N)C(O)=O)[C@@H](O)CCCC(O)=O|5S-hydroxy,6R-(S-cysteinyl),7E,9E,11Z,14Z-eicosatetraenoic acid|(7E,9E,11Z,14Z)-(5S,6R)-6-(Cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate|C23H37NO5S|0|InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1",,,CHEBI:15650,,,,,,,,,,,,,,,,,,,,,,,CHEBI:15650,,,,,leukotriene E4,,CHEBI:15650,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400507,"[""GABRA2 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400507,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRA2 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200611,"[""NME3 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200611,,,,,,,,,,,,,,,,,,,,,,,,,,,,NME3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000030,"[""ACVR2A kinase domain""]",,"Activin A receptor, type IIA; ActR2; ACTRII; ACVR2; ACVR2A",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Activin A receptor, type IIA; ActR2; ACTRII; ACVR2; ACVR2A",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000030,,,,,,,,,,,,,,,,,,,200029,,,,,,,,,ACVR2A kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000003,"[""intestinal cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000003,,,,,,,BrendaTissueOBO,,BTO:0000003,,,,,,,,,,,,,,,,,,,intestinal cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000362,"[""THR529 in BRAF""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000362,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR529 in BRAF,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000007,"[""ABL1(F317I)-nonphosphorylated kinase domain""]",,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",false,,,http://www.drugtargetontology.org/dto/DTO_61000006,,,,,,,,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000007,,,,,,,,,,,,,,,,,,,"200005, 200006",,,,,,,,,ABL1(F317I)-nonphosphorylated kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200119,"[""GHRHR gene""]",,"A growth hormone-releasing hormone receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02643] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400047,,,,,,,,"A growth hormone-releasing hormone receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02643] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200119,,,,,,,,,,,,,,,,2692,GHRHR,,,,,,,,,,,GHRHR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000100,"[""MET107 in MK13""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000100,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET107 in MK13,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100215,"[""Probable g-protein coupled receptor 88""]",,"A G-protein coupled receptor 88 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9GZN0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 88 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9GZN0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100215,,,,https://pharos.nih.gov/idg/targets/Q9GZN0,,,,,,,,,,,,,GPR88,STRG,,Q9GZN0,,,,,,,,Probable g-protein coupled receptor 88,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200147,"[""HCN4 gene""]",,"This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400343,,,,,,,,"This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200147,,,,,,,,,,,,,,,,10021,HCN4,,,,,,,,,,,HCN4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200097,"[""FFAR4 gene""]",,"A free fatty acid receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q5NUL3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400040,,,,,,,,"A free fatty acid receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q5NUL3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200097,,,,,,,,,,,,,,,,338557,FFAR4,GPR120|GPR129|O3FAR1|PGR4,,,,,,,,,,FFAR4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100528,"[""Serine/threonine-protein kinase tousled-like 1""]",,"serine/threonine-protein kinase tousled-like 1 (TLK1)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase tousled-like 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UKI8] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300235,,,,,,,,"serine/threonine-protein kinase tousled-like 1 (TLK1)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase tousled-like 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UKI8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100528,,,,https://pharos.nih.gov/idg/targets/Q9UKI8,,,,,,,,,,,,,TLK1,KIAA0137,,Q9UKI8,,,,,,,,Serine/threonine-protein kinase tousled-like 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_18357,"[""(R)-noradrenaline""]","(R)-norepinephrine|L-Noradrenaline|169.074|Norepinephrine|(-)-arterenol|169.17780|norepinefrina|4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol|norepinephrinum|(R)-(-)-norepinephrine|SFLSHLFXELFNJZ-QMMMGPOBSA-N|Arterenol|L-NOREPINEPHRINE|C8H11NO3|Noradrenaline|(R)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol|(-)-norepinephrine|norepinephrine|NC[C@H](O)c1ccc(O)c(O)c1|(-)-noradrenaline|InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1|0",The R-enantiomer of noradrenaline.,false,,,http://purl.obolibrary.org/obo/CHEBI_32952,,,,,,,KEGG:C00547|DrugBank:DB00368|PDBeChem:LNR|KEGG:D00076|Drug_Central:1960|CAS:51-41-2|Wikipedia:Norepinephrine|Beilstein:2804840|Reaxys:2804840|HMDB:HMDB00216|Beilstein:4231961|KNApSAcK:C00001424|PDBeChem:LT4,The R-enantiomer of noradrenaline.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:43725|CHEBI:258884|CHEBI:14668|CHEBI:25592|CHEBI:1,,"4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol",,chebi_ontology,"(R)-norepinephrine|L-Noradrenaline|169.074|Norepinephrine|(-)-arterenol|169.17780|norepinefrina|4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol|norepinephrinum|(R)-(-)-norepinephrine|SFLSHLFXELFNJZ-QMMMGPOBSA-N|Arterenol|L-NOREPINEPHRINE|C8H11NO3|Noradrenaline|(R)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol|(-)-norepinephrine|norepinephrine|NC[C@H](O)c1ccc(O)c(O)c1|(-)-noradrenaline|InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1|0",,,CHEBI:18357,,,,,,,,,,,,,,,,,,,,,,,CHEBI:18357,,,,,(R)-noradrenaline,,CHEBI:18357,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4166,"[""syphilis""]",,"A primary bacterial infectious disease that is a sexually transmitted systemic disease, has_material_basis_in Treponema pallidum subsp pallidum, which is transmitted_by sexual contact, transmitted_by blood product transfusion, transmitted_by congenital method from mother to fetus or transmitted_by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.",false,,,http://purl.obolibrary.org/obo/DOID_0050338,,,,,,,,"A primary bacterial infectious disease that is a sexually transmitted systemic disease, has_material_basis_in Treponema pallidum subsp pallidum, which is transmitted_by sexual contact, transmitted_by blood product transfusion, transmitted_by congenital method from mother to fetus or transmitted_by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4166,,,DOID:11095,UMLS_CUI:C0007939|ICD10CM:A51.0|MESH:D002601|SNOMEDCT_US_2016_03_01:58433006|SNOMEDCT_US_2016_03_01:266127002,syphilitic chancre,,disease_ontology,,DOID:4166,http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease|http://purl.obolibrary.org/obo/doid#sexually_transmitted_infectious_disease,,,,,,,,,,,,,,,,,,syphilis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002882,"[""32D cell""]",,Mouse bone marrow cell line; established from long-term bone marrow cultures of C3H/HeJ mice infected with the Friend murine leukemia virus.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000264,,,,,,,,Mouse bone marrow cell line; established from long-term bone marrow cultures of C3H/HeJ mice infected with the Friend murine leukemia virus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002882,,,,,,,BrendaTissueOBO,,BTO:0002882,,,,,,,,,,,,,,,,,,,32D cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4952,"[""postpoliomyelitis syndrome""]",,"A poliomyelitis that results_in atrophy located_in muscle, many years after the initial infection, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3. It is characterized by new weakening in muscles that were previously affected by the polio infection and in muscles that were unaffected. The infection has_symptom muscle weakness, has_symptom muscle pain, has_symptom sleep apnea, and has_symptom breathing problems.",false,,,http://purl.obolibrary.org/obo/DOID_4953,,,,,,,,"A poliomyelitis that results_in atrophy located_in muscle, many years after the initial infection, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3. It is characterized by new weakening in muscles that were previously affected by the polio infection and in muscles that were unaffected. The infection has_symptom muscle weakness, has_symptom muscle pain, has_symptom sleep apnea, and has_symptom breathing problems.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4952,,,,SNOMEDCT_US_2016_03_01:367094007|MESH:D016262|SNOMEDCT_US_2016_03_01:31097004|UMLS_CUI:C0080040|ICD10CM:G14,Postpolio syndrome,,disease_ontology,,DOID:4952,,,,,,,,,,,,,,,,,,,postpoliomyelitis syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6255,"[""growth hormone secreting pituitary adenoma""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_5395,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6255,,,,NCI:C7461|SNOMEDCT_US_2016_03_01:254957009|OMIM:102200|UMLS_CUI:C0346302|MESH:D049912,Growth Hormone Producing adenoma of the Pituitary|growth hormone secreting adenoma of pituitary|Somatotroph adenoma (disorder),,disease_ontology,,DOID:6255,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,growth hormone secreting pituitary adenoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002086,"[""posterior chamber of the eye""]",,"That portion of the aqueous-containing space between the cornea and the lens which is bounded in front by the iris, and behind by the lens and ciliary zonule.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002085,,,,,,,,"That portion of the aqueous-containing space between the cornea and the lens which is bounded in front by the iris, and behind by the lens and ciliary zonule.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002086,,,,,,,BrendaTissueOBO,camera oculi posterior|camera posterior bulbi,BTO:0002086,,,,,,,,,,,,,,,,,,,posterior chamber of the eye,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5204,"[""fructose-1,6-bisphosphatase deficiency""]",,"A carbohydrate metabolic disorder that has_material_basis_in a deficiency of fructose-1,6-bisphosphatase resulting in hypoglycemia and metabolic acidosis on fasting due to insufficient fructose bisphosphatase for gluconeogenesis.",false,,,http://purl.obolibrary.org/obo/DOID_2978,,,,,,,,"A carbohydrate metabolic disorder that has_material_basis_in a deficiency of fructose-1,6-bisphosphatase resulting in hypoglycemia and metabolic acidosis on fasting due to insufficient fructose bisphosphatase for gluconeogenesis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5204,,,,OMIM:229700|MESH:D015319|SNOMEDCT_US_2016_03_01:28183005|ICD10CM:E74.19|UMLS_CUI:C0016756,"fructose 1 phosphate aldolase deficiency|fructose-1,6-diphosphatase deficiency",,disease_ontology,,DOID:5204,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,"fructose-1,6-bisphosphatase deficiency",,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200189,"[""GPR31 gene""]",,"A 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00270] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00270] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200189,,,,,,,,,,,,,,,,2853,GPR31,,,,,,,,,,,GPR31 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000238,"[""PHE103 in CDK9""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000238,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE103 in CDK9,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100804,"[""Trace amine-associated receptor 5""]",,"A trace amine-associated receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14804] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A trace amine-associated receptor 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14804] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100804,,,,https://pharos.nih.gov/idg/targets/O14804,,,,,,,,,,,,,TAAR5,PNR,,O14804,,,,,,,,Trace amine-associated receptor 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9283,"[""borderline glaucoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1686,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9283,,,,ICD10CM:H40.00|UMLS_CUI:C0549470|SNOMEDCT_US_2016_03_01:193532005|SNOMEDCT_US_2016_03_01:47891005|SNOMEDCT_US_2016_03_01:359633007|ICD9CM:365.00,Preglaucoma,,disease_ontology,,DOID:9283,,,,,,,,,,,,,,,,,,,borderline glaucoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3852,"[""Peutz-Jeghers syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_5295,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3852,,,DOID:4134|DOID:6252|DOID:4133|DOID:6253,NCI:C4733|SNOMEDCT_US_2016_03_01:277161008|UMLS_CUI:C0265323|UMLS_CUI:C0456487|ICD10CM:Q85.8|SNOMEDCT_US_2016_03_01:54411001|UMLS_CUI:C1333088|SNOMEDCT_US_2016_03_01:157029009|NCI:C3324|OMIM:175200|MESH:D010580|UMLS_CUI:C0031269|SNOMEDCT_US_2016_03_01:53633000|NCI:C7755,Peutz Jeghers polyp|gastric Peutz-Jeghers polyp|Peutz Jeghers colon polyp|Peutz-Jeghers polyp of small Intestine|peutz-jeghers small bowel hamartoma|Colonic hamartomatous polyp,,disease_ontology,,DOID:3852,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Peutz-Jeghers syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100388,"[""Olfactory receptor 51B4""]",,"An olfactory receptor 51B4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y5P0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 51B4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y5P0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100388,,,,https://pharos.nih.gov/idg/targets/Q9Y5P0,,,,,,,,,,,,,OR51B4,,,Q9Y5P0,,,,,,,,Olfactory receptor 51B4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001332,"[""DU-145 cell""]",,"Human prostate carcinoma, established from the tumor tissue removed from the metastatic central nervous system lesion of a 69-year-old man with prostate carcinoma in 1975.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001033,,,,,,,,"Human prostate carcinoma, established from the tumor tissue removed from the metastatic central nervous system lesion of a 69-year-old man with prostate carcinoma in 1975.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001332,,,,,,,BrendaTissueOBO,DU145 cell,BTO:0001332,,,,,,,,,,,,,,,,,,,DU-145 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200260,"[""KSR1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400126,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200260,,,,,,,,,,,,,,,,8844,KSR1,KSR,,,,,,,,,,KSR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200305,"[""SCNN1D gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400479,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200305,,,,,,,,,,,,,,,,6339,SCNN1D,DNACH,,,,,,,,,,SCNN1D gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100424,"[""Olfactory receptor 52J3""]",,"An olfactory receptor 52J3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH60] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 52J3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH60] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100424,,,,https://pharos.nih.gov/idg/targets/Q8NH60,,,,,,,,,,,,,OR52J3,,,Q8NH60,,,,,,,,Olfactory receptor 52J3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001339,"[""synovia""]",,"A transparent viscid lubricating fluid secreted by a membrane of an articulation, bursa, or tendon sheath.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A transparent viscid lubricating fluid secreted by a membrane of an articulation, bursa, or tendon sheath.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001339,,,,,,,BrendaTissueOBO,synovial fluid,BTO:0001339,,,,,,,,,,,,,,,,,,,synovia,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005630,"[""sensory ganglion""]",,"The ganglion on the roots of the cranial nerves, containing the cell bodies of sensory neurons; The spinal ganglion.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000497,,,,,,,,"The ganglion on the roots of the cranial nerves, containing the cell bodies of sensory neurons; The spinal ganglion.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005630,Marion,2014-04-02T10:52:35Z,,,,,BrendaTissueOBO,,BTO:0005630,,,,,,,,,,,,,,,,,,,sensory ganglion,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300117,"[""ABL family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300117,,,,,,,,,,,,,,,,,,,,,,,,,,,,ABL family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050328,"[""congenital hypothyroidism""]",,A hypothyroidism that is present at birth.,false,,,http://purl.obolibrary.org/obo/DOID_1459,,,,,,,,A hypothyroidism that is present at birth.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050328,,,DOID:11632|DOID:11631,OMIM:274700|SNOMEDCT_US_2016_03_01:154660000|ICD10CM:E03.1|OMIM:614450|SNOMEDCT_US_2016_03_01:154661001|SNOMEDCT_US_2016_03_01:190273009|MESH:D003409|OMIM:607200|OMIM:274900|UMLS_CUI:C0010308|ICD10CM:E00.1|OMIM:275200|SNOMEDCT_US_2016_03_01:75065003|NCI:C26734|SNOMEDCT_US_2016_03_01:267376007|OMIM:274500|SNOMEDCT_US_2016_03_01:217710005|SNOMEDCT_US_2016_03_01:3614006|OMIM:218700|OMIM:274400|OMIM:275100|OMIM:225250|ICD9CM:243|OMIM:609893|SNOMEDCT_US_2016_03_01:190268003|UMLS_CUI:C0342200|SNOMEDCT_US_2016_03_01:267465007|NCI:C98921,cretinism,,disease_ontology,,DOID:0050328,,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,congenital hypothyroidism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100365,"[""Olfactory receptor 2AK2""]",,"An olfactory receptor 2AK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG84] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2AK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG84] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100365,,,,https://pharos.nih.gov/idg/targets/Q8NG84,,,,,,,,,,,,,OR2AK2,OR2AK1P,,Q8NG84,,,,,,,,Olfactory receptor 2AK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000035,"[""LEU116 in CSNK1G3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000035,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU116 in CSNK1G3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400501,"[""Beta-4/CHRNB4 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400501,,,,,,,,,,,,,,,,,,,,,,,,,,,,Beta-4/CHRNB4 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001282,"[""HT-1080 cell""]",,Human fibrosarcoma cell line; established from the biopsy from a fibrosarcoma of a 35-year-old Caucasian man in 1972; patient did not receive any chemo- or radiotherapy.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000460,,,,,,,,Human fibrosarcoma cell line; established from the biopsy from a fibrosarcoma of a 35-year-old Caucasian man in 1972; patient did not receive any chemo- or radiotherapy.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001282,,,,,,,BrendaTissueOBO,,BTO:0001282,,,,,,,,,,,,,,,,,,,HT-1080 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_29947,"[""glycine residue""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_33700,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:29947,,,CHEBI:29946|CHEBI:13347|CHEBI:42772,RESID:AA0008|PDBeChem:GLY_LL,glycine residue,,chebi_ontology,glycyl|G|glycine|C2H3NO|57.021|57.05136|-HN-CH2-CO-|0|-Gly-,CHEBI:29947,http://purl.obolibrary.org/obo/chebi#3_STAR,,,,,,,,,,,,,,,,,,glycine residue,,,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12698,"[""gynecomastia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1923,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12698,,,,SNOMEDCT_US_2016_03_01:266646002|ICD10CM:N62|NCI:C3073|MESH:D006177|SNOMEDCT_US_2016_03_01:155963008|UMLS_CUI:C0018418|SNOMEDCT_US_2016_03_01:4754008|SNOMEDCT_US_2016_03_01:198112004,,,disease_ontology,,DOID:12698,,,,,,,,,,,,,,,,,,,gynecomastia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200345,"[""OR13C9 gene""]",,"An olfactory receptor 13C9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 13C9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGT0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200345,,,,,,,,,,,,,,,,286362,OR13C9,,,,,,,,,,,OR13C9 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000451,"[""TYRO3 kinase domain""]",,TYRO3 protein tyrosine kinase; BYK; Dtk; FLJ16467; RSE; Sky; Tif; TYRO3; Tyro3/Sky,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,TYRO3 protein tyrosine kinase; BYK; Dtk; FLJ16467; RSE; Sky; Tif; TYRO3; Tyro3/Sky,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000451,,,,,,,,,,,,,,,,,,,200454,,,,,,,,,TYRO3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400003,"[""Class B secretin like gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400001,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400003,,,,,,,,,,,,,,,,,,,,,,,,,,,,Class B secretin like gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100542,"[""Testis-specific serine/threonine-protein kinase 3""]",,"A testis-specific serine/threonine-protein kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96PN8] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300238,,,,,,,,"A testis-specific serine/threonine-protein kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96PN8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100542,,,,https://pharos.nih.gov/idg/targets/Q96PN8,,,,,,,,,,,,,TSSK3,SPOGA3|STK22C,,Q96PN8,,,,,,,,Testis-specific serine/threonine-protein kinase 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200777,"[""TAS2R13 gene""]",,"A taste receptor type 2 member 13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYV9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400014,,,,,,,,"A taste receptor type 2 member 13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYV9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200777,,,,,,,,,,,,,,,,50838,TAS2R13,,,,,,,,,,,TAS2R13 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200409,"[""OR52A4 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200409,,,,,,,,,,,,,,,,390053,OR52A4,,,,,,,,,,,OR52A4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200499,"[""OR1L6 gene""]",,"An olfactory receptor 1L6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1L6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200499,,,,,,,,,,,,,,,,392390,OR1L6,OR1L7,,,,,,,,,,OR1L6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200339,"[""TTYH1 gene""]",,"This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-independent, volume-sensitive large conductance chloride(-) channel. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jan 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400373,,,,,,,,"This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-independent, volume-sensitive large conductance chloride(-) channel. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jan 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200339,,,,,,,,,,,,,,,,57348,TTYH1,,,,,,,,,,,TTYH1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200208,"[""GPR75 gene""]",,"A G-protein coupled receptor 75 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95800] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 75 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95800] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200208,,,,,,,,,,,,,,,,10936,GPR75,,,,,,,,,,,GPR75 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003318,"[""INS-1 823/13 cell""]",,Subline of INS-1 rat insulinoma cell line with optimized glucose-sensitive insulin secretion.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Subline of INS-1 rat insulinoma cell line with optimized glucose-sensitive insulin secretion.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003318,,,,,,,BrendaTissueOBO,832/13 INS-1 cell|INS-1 (823/13) cell|INS 823/13 cell|INS1 832/13 cell|832/13 cell|INS823/13 cell|INS-1 (clone 823-13) cell,BTO:0003318,,,,,,,,,,,,,,,,,,,INS-1 823/13 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2320,"[""obstructive lung disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_850,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2320,,,,UMLS_CUI:C0600260|MESH:D008173,respiratory airway obstruction,,disease_ontology,,DOID:2320,,,,,,,,,,,,,,,,,,,obstructive lung disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100193,"[""Interleukin-1 receptor-associated kinase 4""]",,An interleukin-1 receptor-associated kinase 4 encoded in the genome of human. [PRO:CNA] |interleukin-1 receptor-associated kinase 4 (IRAK4)  with  no mutation  in a nonphosphorylated state,false,,,http://www.drugtargetontology.org/dto/DTO_03300166,,,,,,,,An interleukin-1 receptor-associated kinase 4 encoded in the genome of human. [PRO:CNA] |interleukin-1 receptor-associated kinase 4 (IRAK4)  with  no mutation  in a nonphosphorylated state,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100193,,,,https://pharos.nih.gov/idg/targets/Q9NWZ3,,,,,,,,,,,,,IRAK4,,,Q9NWZ3,,,,,,,,Interleukin-1 receptor-associated kinase 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000224,"[""liver cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000224,,,,,,,BrendaTissueOBO,,BTO:0000224,,,,,,,,,,,,,,,,,,,liver cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200267,"[""MTNR1A gene""]",,"A melatonin receptor type 1A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48039] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400065,,,,,,,,"A melatonin receptor type 1A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48039] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200267,,,,,,,,,,,,,,,,4543,MTNR1A,,,,,,,,,,,MTNR1A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02302003,"[""5-HT4 receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300017,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02302003,,,,,,,,,,,,,,,,,,,,,,,,,,,,5-HT4 receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300002,"[""Class A rhodopsin like""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300001,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,Class A rhodopsin like,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100539,"[""Olfactory receptor 2m2""]",,"An olfactory receptor 2M2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R28] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2M2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R28] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100539,,,,https://pharos.nih.gov/idg/targets/Q96R28,,,,,,,,,,,,,OR2M2,,,Q96R28,,,,,,,,Olfactory receptor 2m2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217464,"[""Retinoic acid-related orphans gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00200002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217464,,,,,,,,,,,,,,,,,,,,,,,,,,,,Retinoic acid-related orphans gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002632,"[""larval cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002632,,,,,,,BrendaTissueOBO,,BTO:0002632,,,,,,,,,,,,,,,,,,,larval cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200087,"[""EDNRB gene""]",,"An endothelin B receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P24530] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400099,,,,,,,,"An endothelin B receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P24530] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200087,,,,,,,,,,,,,,,,1910,EDNRB,ETRB,,,,,,,,,,EDNRB gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002219,"[""adrenocortical carcinoma cell""]",,A malignant adrenal cortical tumor that can cause endocrine disorders such as Cushing's syndrome or adrenogenital syndrome.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A malignant adrenal cortical tumor that can cause endocrine disorders such as Cushing's syndrome or adrenogenital syndrome.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002219,,,,,,,BrendaTissueOBO,adrenal cortex cancer cell|adrenal cortical carcinoma cell|carcinoma of adrenal cortex|ACC cell|adrenocortical tumor cell,BTO:0002219,,,,,,,,,,,,,,,,,,,adrenocortical carcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300229,"[""SGK495 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300229,,,,,,,,,,,,,,,,,,,,,,,,,,,,SGK495 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6050,"[""esophageal disease""]",,A gastrointestinal system disease that is located_in the esophagus.,false,,,http://purl.obolibrary.org/obo/DOID_77,,,,,,,,A gastrointestinal system disease that is located_in the esophagus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6050,,,DOID:10117|DOID:11798|DOID:10118,NCI:C3027|SNOMEDCT_US_2016_03_01:37657006|ICD9CM:530|MESH:D004935|SNOMEDCT_US_2016_03_01:155680005|ICD10CM:K22.9|SNOMEDCT_US_2016_03_01:266497000|UMLS_CUI:C0014852|SNOMEDCT_US_2016_03_01:155671005|ICD9CM:530.9|SNOMEDCT_US_2016_03_01:196626000,esophageal Ulcer,,disease_ontology,,DOID:6050,,,,,,,,,,,,,,,,,,,esophageal disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000026,"[""ABL1-phosphorylated kinase domain""]",,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",false,,,http://www.drugtargetontology.org/dto/DTO_61000003,,,,,,,,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000026,,,,,,,,,,,,,,,,,,,200025,,,,,,,,,ABL1-phosphorylated kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_15422,"[""ATP""]","H4atp|
Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
|Phosphobion|Atriphos|5'-(Tetrahydrogen triphosphate) Adenosine|Adenylpyrophosphorate|Striadyne|Glucobasin|
[[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid
|ZKHQWZAMYRWXGA-KQYNXXCUSA-N|C10H16N5O13P3|
[[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid
|5'-ATP|Adynol|ADENOSINE-5'-TRIPHOSPHATE|Adenosine 5'-triphosphate|Atipi|Myotriphos|Adenosine triphosphate|adenosine 5'-(tetrahydrogen triphosphate)|
InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
|Triphosphaden|
({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid
|Adenosine 5'-triphosphoric acid|Triadenyl|Triphosphoric acid adenosine ester|Fosfobion|Cardenosine|Adenylpyrophosphoric acid|Adetol|Adenosine 5'-triphosphorate|Adephos","
An adenosine 5'-phosphate in which the 5'-phosphate is a triphosphate group. It is involved in the transportation of chemical energy during metabolic pathways.
",false,,,http://purl.obolibrary.org/obo/CHEBI_36976,,,,,,,CiteXplore:7836519|PDBeChem:ATP|Gmelin:34857|CiteXplore:12137852|CiteXplore:15013648|CiteXplore:11743516|CiteXplore:15882454|CiteXplore:14707763|Patent:US3079379|CiteXplore:15490415|Beilstein:73010|KNApSAcK:C00001491|CiteXplore:16439602|CiteXplore:8882021|CiteXplore:7683296|CiteXplore:15129319|CiteXplore:3338588|KEGG COMPOUND:56-65-5|CiteXplore:15993662|Wikipedia:Adenosine triphosphate|KEGG COMPOUND:C00002|KEGG DRUG:D08646|CiteXplore:2737369|CiteXplore:11157473|ChemIDplus:56-65-5|MetaCyc:ATP|DrugBank:DB00171|Wikipedia:Adenosine_triphosphate|CiteXplore:14696970|HMDB:HMDB00538|Reaxys:73010,"
An adenosine 5'-phosphate in which the 5'-phosphate is a triphosphate group. It is involved in the transportation of chemical energy during metabolic pathways.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:2359|CHEBI:40938|CHEBI:10789|CHEBI:22249|CHEBI:13236|CHEBI:10841,,ATP|adenosine 5'-(tetrahydrogen triphosphate),,chebi_ontology,"H4atp|
Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
|Phosphobion|Atriphos|5'-(Tetrahydrogen triphosphate) Adenosine|Adenylpyrophosphorate|Striadyne|Glucobasin|
[[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid
|ZKHQWZAMYRWXGA-KQYNXXCUSA-N|C10H16N5O13P3|
[[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid
|5'-ATP|Adynol|ADENOSINE-5'-TRIPHOSPHATE|Adenosine 5'-triphosphate|Atipi|Myotriphos|Adenosine triphosphate|adenosine 5'-(tetrahydrogen triphosphate)|
InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
|Triphosphaden|
({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid
|Adenosine 5'-triphosphoric acid|Triadenyl|Triphosphoric acid adenosine ester|Fosfobion|Cardenosine|Adenylpyrophosphoric acid|Adetol|Adenosine 5'-triphosphorate|Adephos",,,CHEBI:15422,,,,,,,,,,,,,,,,,,,,,,,CHEBI:15422,,,,,ATP,,CHEBI:15422,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2723,"[""dermatitis""]",,"A skin disease characterized by itchy, erythematous, vesicular, weeping and crusting patches of skin.",false,,,http://purl.obolibrary.org/obo/DOID_37,,,,,,,,"A skin disease characterized by itchy, erythematous, vesicular, weeping and crusting patches of skin.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2723,,,DOID:8614|DOID:8917,SNOMEDCT_US_2016_03_01:267847004|SNOMEDCT_US_2016_03_01:703938007|SNOMEDCT_US_2016_03_01:43116000|NCI:C2983|MESH:D003872|SNOMEDCT_US_2016_03_01:156358005|SNOMEDCT_US_2016_03_01:182782007|SNOMEDCT_US_2016_03_01:156388001|UMLS_CUI:C0011603|ICD10CM:L30.9|SNOMEDCT_US_2016_03_01:200884006|SNOMEDCT_US_2016_03_01:238538009|SNOMEDCT_US_2016_03_01:4979002|SNOMEDCT_US_2016_03_01:267856007,skin inflammation|eczema,,disease_ontology,,DOID:2723,,,,,,,,,,,,,,,,,,,dermatitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400054,"[""Adrenomedullin receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400054,,,,,,,,,,,,,,,,,,,,,,,,,,,,Adrenomedullin receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300297,"[""YSK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300187,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300297,,,,,,,,,,,,,,,,,,,,,,,,,,,,YSK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200679,"[""OR7C2 gene""]",,"An olfactory receptor 7C2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60412] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 7C2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60412] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200679,,,,,,,,,,,,,,,,26658,OR7C2,OR7C3,,,,,,,,,,OR7C2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10003,"[""sensorineural hearing loss""]",,OMIM mapping confirmed by DO. [LS].,false,,,http://purl.obolibrary.org/obo/DOID_2952,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10003,,,DOID:12112|DOID:12114|DOID:11053,NCI:C34662|SNOMEDCT_US_2016_03_01:155256000|ICD9CM:389.10|UMLS_CUI:C0018784|UMLS_CUI:C0018776|NCI:C26739|SNOMEDCT_US_2016_03_01:267770004|UMLS_CUI:C0018780|SNOMEDCT_US_2016_03_01:48758008|SNOMEDCT_US_2016_03_01:232326009|MESH:D006313|SNOMEDCT_US_2016_03_01:194421002|OMIM:304400|NCI:C34663|ICD10CM:H91.9|SNOMEDCT_US_2016_03_01:194427003|MESH:D006319|SNOMEDCT_US_2016_03_01:60700002|ICD10CM:H90.5|ICD9CM:389.14|MESH:D006316|ICD9CM:389.1|SNOMEDCT_US_2016_03_01:68467004,Sensorineural Deafness|High frequency deafness|Perceptive deafness|central hearing loss|high-frequency hearing loss|Perceptive hearing loss or deafness|High Frequency Hearing Loss|Sensory hearing loss|Perceptive hearing loss,,disease_ontology,,DOID:10003,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,sensorineural hearing loss,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8465,"[""retinoschisis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_8466,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8465,,,,SNOMEDCT_US_2016_03_01:44268007|SNOMEDCT_US_2016_03_01:193330003|MESH:D041441|ICD10CM:H33.10|ICD9CM:361.10|UMLS_CUI:C0152439|NCI:C85046|SNOMEDCT_US_2016_03_01:389992006,,,disease_ontology,,DOID:8465,,,,,,,,,,,,,,,,,,,retinoschisis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100058,"[""V816 in KIT(D816V)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100058,,,,,,,,,,,,,,,,,,,,,,,,,,,,V816 in KIT(D816V),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003306,"[""Mat-Ly-Lu cell""]",,Rat prostate cancer cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001033,,,,,,,,Rat prostate cancer cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003306,,,,,,,BrendaTissueOBO,MatLyLu cell,BTO:0003306,,,,,,,,,,,,,,,,,,,Mat-Ly-Lu cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100715,"[""Olfactory receptor 9G4""]",,"An olfactory receptor 9G4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 9G4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGQ1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100715,,,,https://pharos.nih.gov/idg/targets/Q8NGQ1,,,,,,,,,,,,,OR9G4,,,Q8NGQ1,,,,,,,,Olfactory receptor 9G4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400021,"[""Melanocortin receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400021,,,,,,,,,,,,,,,,,,,,,,,,,,,,Melanocortin receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000130,"[""EGFR(S752-I759del) kinase domain""]",,"Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); EGFR; ERBB; ERBB1; HER1; mENA; PIG61",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000130,,,,,,,,,,,,,,,,,,,200132,,,,,,,,,EGFR(S752-I759del) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050711,"[""aceruloplasminemia""]",,An iron metabolism disease that has_material_basis_in a mutation in the ceruloplasmin gene characterized by progressive neurodegeneration of the retina and basal ganglia and diabetes mellitus.,false,,,http://purl.obolibrary.org/obo/DOID_2351,,,,,,,,An iron metabolism disease that has_material_basis_in a mutation in the ceruloplasmin gene characterized by progressive neurodegeneration of the retina and basal ganglia and diabetes mellitus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050711,lschriml,2012-05-22T11:47:25Z,,OMIM:604290,,,disease_ontology,,DOID:0050711,,,,,,,,,,,,,,,,,,,aceruloplasminemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300053,"[""Purinoceptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300053,,,,,,,,,,,,,,,,,,,,,,,,,,,,Purinoceptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400408,"[""Gamma-aminobutyric acid receptor subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400328,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400408,,,,,,,,,,,,,,,,,,,,,,,,,,,,Gamma-aminobutyric acid receptor subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000426,"[""erythroleukemia cell""]",,"Cancer cell of the blood-forming tissues in which large numbers of immature, abnormal red blood cells are found in the blood and bone marrow.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001271|http://purl.obolibrary.org/obo/BTO_0000583,,,,,,,,"Cancer cell of the blood-forming tissues in which large numbers of immature, abnormal red blood cells are found in the blood and bone marrow.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000426,,,,,,,BrendaTissueOBO,,BTO:0000426,,,,,,,,,,,,,,,,,,,erythroleukemia cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117478,"[""Nuclear receptor subfamily 0 group b member 1""]",,"A nuclear receptor subfamily 0 group B member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51843] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117459,,,,,,,,"A nuclear receptor subfamily 0 group B member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51843] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117478,,,,https://pharos.nih.gov/idg/targets/P51843,,,,,,,,,,,,,NR0B1,DAX1,,P51843,,,,,,,,Nuclear receptor subfamily 0 group b member 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003866,"[""APUD cell""]",,"A group of apparently unrelated cells that secrete most of the body's hormones, with the exception of steroids.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A group of apparently unrelated cells that secrete most of the body's hormones, with the exception of steroids.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003866,,,,,,,BrendaTissueOBO,,BTO:0003866,,,,,,,,,,,,,,,,,,,APUD cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3277,"[""thymus cancer""]",,An immune system cancer located_in the thymus.,false,,,http://purl.obolibrary.org/obo/DOID_533|http://purl.obolibrary.org/obo/DOID_170|http://purl.obolibrary.org/obo/DOID_0060073,,,,,,,,An immune system cancer located_in the thymus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3277,,,DOID:10143,ICD9CM:164.0|NCI:C4962|SNOMEDCT_US_2016_03_01:94096009|SNOMEDCT_US_2016_03_01:363434003|MESH:D013953|ICD10CM:C37|UMLS_CUI:C0751552,thymic neoplasm|neoplasm of thymus (disorder)|Thymic tumor,,disease_ontology,,DOID:3277,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,thymus cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391019,"[""Inositol phosphokinase (IPK) family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300323,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391019,,,,,,,,,,,,,,,,,,,,,,,,,,,,Inositol phosphokinase (IPK) family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100178,"[""G-protein coupled receptor 15""]",,"A G-protein coupled receptor 15 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49685] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 15 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49685] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100178,,,,https://pharos.nih.gov/idg/targets/P49685,,,,,,,,,,,,,GPR15,,,P49685,,,,,,,,G-protein coupled receptor 15,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001208,"[""larynx""]",,"The modified upper part of the trachea of air-breathing vertebrates that in humans, most other mammals, and a few lower forms contains the vocal cords.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The modified upper part of the trachea of air-breathing vertebrates that in humans, most other mammals, and a few lower forms contains the vocal cords.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001208,,,,,,,BrendaTissueOBO,Kehlkopf,BTO:0001208,,,,,,,,,,,,,,,,,,,larynx,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400101,"[""Kinase gene""]",,"In biochemistry, a kinase is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates.",false,,,http://www.drugtargetontology.org/dto/DTO_00200000,,,,,,,,"In biochemistry, a kinase is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400101,,,,,,,,,,,,,,,,,,,,,,,,,,,https://en.wikipedia.org/wiki/Kinase,Kinase gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5433,"[""urinary tract papillary transitional cell benign neoplasm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_731|http://purl.obolibrary.org/obo/DOID_3179,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5433,,,DOID:6120,NCI:C27883|UMLS_CUI:C1335329|NCI:C6192|UMLS_CUI:C1334282,Papillary transitional cell neoplasm of the urinary tract|urinary tract inverted papilloma|Inverted papilloma of urinary tract,,disease_ontology,,DOID:5433,,,,,,,,,,,,,,,,,,,urinary tract papillary transitional cell benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000151,"[""CCL14""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000151,,,,,,,,,,,,,,,,,,,,,,,,,,,,CCL14,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300405,"[""CNGA4 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300343,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300405,,,,,,,,,,,,,,,,,,,,,,,,,,,,CNGA4 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4154,"[""dentinogenesis imperfecta""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_1091,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4154,,,,OMIM:125500|ICD10CM:K00.5|SNOMEDCT_US_2016_03_01:196286005|UMLS_CUI:C0011436|NCI:C84667|SNOMEDCT_US_2016_03_01:45742009|MESH:D003811|SNOMEDCT_US_2016_03_01:367461002|OMIM:125490,,,disease_ontology,,DOID:4154,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,dentinogenesis imperfecta,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100385,"[""Serine/threonine-protein kinase pak 2""]",,"serine/threonine-protein kinase pak 2 (PAK2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase PAK 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13177] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300303,,,,,,,,"serine/threonine-protein kinase pak 2 (PAK2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase PAK 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13177] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100385,,,,https://pharos.nih.gov/idg/targets/Q13177,,,,,,,,,,,,,PAK2,,,Q13177,,,,,,,,Serine/threonine-protein kinase pak 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200145,"[""HCN2 gene""]",,"Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain.[supplied by OMIM, Jul 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400343,,,,,,,,"Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain.[supplied by OMIM, Jul 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200145,,,,,,,,,,,,,,,,610,HCN2,BCNG2,,,,,,,,,,HCN2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000959,"[""esophagus""]",,A muscular tube that in humans is about nine inches (23 centimeters) long and passes from the pharynx down the neck between the trachea and the spinal column and behind the left bronchus where it pierces the diaphragm slightly to the left of the middle line and joins the cardiac end of the stomach.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,,A muscular tube that in humans is about nine inches (23 centimeters) long and passes from the pharynx down the neck between the trachea and the spinal column and behind the left bronchus where it pierces the diaphragm slightly to the left of the middle line and joins the cardiac end of the stomach.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000959,,,,,,,BrendaTissueOBO,oesophagus|gullet,BTO:0000959,,,,,,,,,,,,,,,,,,,esophagus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060067,"[""Pearson syndrome""]",,A mitochondrial metabolism disease that is characterized by sideroblastic anemia and exocrine pancreas dysfunction.,false,,,http://purl.obolibrary.org/obo/DOID_700,,,,,,,,A mitochondrial metabolism disease that is characterized by sideroblastic anemia and exocrine pancreas dysfunction.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060067,,,,OMIM:557000,Pearson Marrow-Pancreas Syndrome,,disease_ontology,,DOID:0060067,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,Pearson syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060061,"[""cutaneous T cell lymphoma""]",,A non-Hodgkin's lymphoma that has material basis in a mutation of T cells.,false,,,http://purl.obolibrary.org/obo/DOID_0050749,,,,,,,,A non-Hodgkin's lymphoma that has material basis in a mutation of T cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060061,,,,MESH:D016410,cutaneous T-cell lymphoma,,disease_ontology,,DOID:0060061,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,cutaneous T cell lymphoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060064,"[""sideroblastic anemia with spinocerebellar ataxia""]",,OMIM mapping confirmed by DO. [LS].,false,,,http://purl.obolibrary.org/obo/DOID_8955,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060064,,,,,ASAT,,disease_ontology,,DOID:0060064,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,sideroblastic anemia with spinocerebellar ataxia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060060,"[""non-Hodgkin lymphoma""]",,A lymphoma that is characterized as any kind of lymphoma except Hodgkin's lymphoma.,false,,,http://purl.obolibrary.org/obo/DOID_0060058,,,,,,,,A lymphoma that is characterized as any kind of lymphoma except Hodgkin's lymphoma.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060060,,,,OMIM:605027,,,disease_ontology,,DOID:0060060,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,non-Hodgkin lymphoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300357,"[""The phagocyte (gp91(phox)) nadph oxidase family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300357,,,,,,,,,,,,,,,,,,,,,,,,,,,,The phagocyte (gp91(phox)) nadph oxidase family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300176,"[""PKD family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300176,,,,,,,,,,,,,,,,,,,,,,,,,,,,PKD family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003179,"[""hamstring muscle""]",,Any of three muscles at the back of the thigh that function to flex and rotate the leg and extend the thigh.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001367,,,,,,,,Any of three muscles at the back of the thigh that function to flex and rotate the leg and extend the thigh.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003179,,,,,,,BrendaTissueOBO,,BTO:0003179,,,,,,,,,,,,,,,,,,,hamstring muscle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200455,"[""OR5H14 gene""]",,"An olfactory receptor 5H14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NHG9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5H14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NHG9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200455,,,,,,,,,,,,,,,,403273,OR5H14,,,,,,,,,,,OR5H14 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100560,"[""Olfactory receptor 2Z1""]",,"An olfactory receptor 2Z1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG97] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2Z1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG97] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100560,,,,https://pharos.nih.gov/idg/targets/Q8NG97,,,,,,,,,,,,,OR2Z1,OR2Z2,,Q8NG97,,,,,,,,Olfactory receptor 2Z1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200603,"[""CKMT2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200603,,,,,,,,,,,,,,,,,,,,,,,,,,,,CKMT2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200320,"[""MAPK8 gene""]",,"The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jun 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400293,,,,,,,,"The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jun 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200320,,,,,,,,,,,,,,,,5599,MAPK8,JNK1|PRKM8|SAPK1,,,,,,,,,,MAPK8 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000015,"[""GLU667 in JAK1(Kin.Dom.2)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29972,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000015,,,,,,,,,,,,,,,,,,,,,,,,,,,,GLU667 in JAK1(Kin.Dom.2),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400257,"[""CDK8 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400136,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400257,,,,,,,,,,,,,,,,,,,,,,,,,,,,CDK8 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000353,"[""PIK3CG kinase domain""]",,"Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; PI3CG; PI3K; PI3Kgamma; PIK3; PIK3CG",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; PI3CG; PI3K; PI3Kgamma; PIK3; PIK3CG",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000353,,,,,,,,,,,,,,,,,,,200335,,,,,,,,,PIK3CG kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100182,"[""Inhibitor of nuclear factor kappa-b kinase subunit beta""]",,"inhibitor of nuclear factor kappa-b kinase subunit beta (IKKB)  with  no mutation  in a nonphosphorylated state|An inhibitor of nuclear factor kappa-B kinase subunit beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14920] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300164,,,,,,,,"inhibitor of nuclear factor kappa-b kinase subunit beta (IKKB)  with  no mutation  in a nonphosphorylated state|An inhibitor of nuclear factor kappa-B kinase subunit beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14920] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100182,,,,https://pharos.nih.gov/idg/targets/O14920,,,,,,,,,,,,,IKBKB,IKKB,,O14920,,,,,,,,Inhibitor of nuclear factor kappa-b kinase subunit beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100430,"[""Olfactory receptor 52n1""]",,"An olfactory receptor 52N1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH53] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 52N1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH53] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100430,,,,https://pharos.nih.gov/idg/targets/Q8NH53,,,,,,,,,,,,,OR52N1,,,Q8NH53,,,,,,,,Olfactory receptor 52n1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100278,"[""Polycystic kidney disease 2-like 1 protein""]",,"A polycystic kidney disease 2-like 1 protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P0L9] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300367,,,,,,,,"A polycystic kidney disease 2-like 1 protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P0L9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100278,,,,https://pharos.nih.gov/idg/targets/Q9P0L9,,,,,,,,,,,,,PKD2L1,PKD2L|PKDL|TRPP3,,Q9P0L9,,,,,,,,Polycystic kidney disease 2-like 1 protein,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400253,"[""BRSK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400116,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400253,,,,,,,,,,,,,,,,,,,,,,,,,,,,BRSK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300570,"[""KCa4.2/KCNT2 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300437,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300570,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCa4.2/KCNT2 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_16755,"[""chenodeoxycholic acid""]","Chenodesoxycholsaeure|7alpha-hydroxylithocholic acid|3a,7a-Dihydroxy-5b-cholan-24-oic acid|C24H40O4|chenic acid|(+)-chenodeoxycholate|3a,7a-Dihydroxy-5b-cholanic acid|3a,7a-Dihydroxy-5b-cholan-24-oate|3a,7a-Dihydroxy-5b-cholanate|anthropodesoxycholic acid|
(4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
|
(4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl]pentanoic acid
|
InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1
|Chenodiol|7a-Hydroxy-desoxycholsaeure|3alpha,7alpha-Dihydroxy-5beta-cholanic acid|(3a,5b,7a)-3,7-dihydroxy-cholan-24-oic acid|Chenodeoxycholate|RUDATBOHQWOJDD-BSWAIDMHSA-N|
(4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]valeric acid
|CDCA|anthropodeoxycholic acid|Chenix|
(4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3,7-bis(oxidanyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
|(+)-chenodeoxycholic acid|(3a,5b,7a)-3,7-dihydroxy-cholan-24-oate|gallodesoxycholic acid|3a,7a-Dihydroxy-5b,14a,17b-cholanic acid|3a,7a-Dihydroxy-5b,14a,17b-cholanate|
[H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]1([H])CC[C@]3(C)[C@]([H])(CC[C@@]3([H])[C@]1([H])[C@H](O)C2)[C@H](C)CCC(O)=O
","
A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively.
",false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,CiteXplore:11907135|KEGG DRUG:D00163|KEGG COMPOUND:C02528|CiteXplore:24448653|PDBeChem:JN3|CiteXplore:22664055|HMDB:HMDB00518|CiteXplore:11248487|CiteXplore:12632357|CiteXplore:2621422|CiteXplore:10889168|KEGG COMPOUND:474-25-9|CiteXplore:24464484|CiteXplore:9051880|CiteXplore:8742915|CiteXplore:12576301|CiteXplore:10542066|CiteXplore:10597755|CiteXplore:11957790|LIPID MAPS:LMST04010032|CiteXplore:8618139|Wikipedia:Chenodiol|CiteXplore:16548228|CiteXplore:10766400|CiteXplore:16037564|ChemIDplus:474-25-9|Wikipedia:Chenodeoxycholic acid|CiteXplore:7601437|CiteXplore:9425933|CiteXplore:10656538|Beilstein:3219887|CiteXplore:15040040|CiteXplore:14582467|DrugBank:DB06777|Reaxys:3219887|CiteXplore:11316487|CiteXplore:11530998|CiteXplore:9664985|CiteXplore:12846445|CiteXplore:10781781|CiteXplore:15185309,"
A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:3593|CHEBI:3588|CHEBI:23094,,"Chenodeoxycholic acid|3alpha,7alpha-dihydroxy-5beta-cholan-24-oic acid",,chebi_ontology,"Chenodesoxycholsaeure|7alpha-hydroxylithocholic acid|3a,7a-Dihydroxy-5b-cholan-24-oic acid|C24H40O4|chenic acid|(+)-chenodeoxycholate|3a,7a-Dihydroxy-5b-cholanic acid|3a,7a-Dihydroxy-5b-cholan-24-oate|3a,7a-Dihydroxy-5b-cholanate|anthropodesoxycholic acid|
(4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
|
(4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl]pentanoic acid
|
InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1
|Chenodiol|7a-Hydroxy-desoxycholsaeure|3alpha,7alpha-Dihydroxy-5beta-cholanic acid|(3a,5b,7a)-3,7-dihydroxy-cholan-24-oic acid|Chenodeoxycholate|RUDATBOHQWOJDD-BSWAIDMHSA-N|
(4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]valeric acid
|CDCA|anthropodeoxycholic acid|Chenix|
(4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3,7-bis(oxidanyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
|(+)-chenodeoxycholic acid|(3a,5b,7a)-3,7-dihydroxy-cholan-24-oate|gallodesoxycholic acid|3a,7a-Dihydroxy-5b,14a,17b-cholanic acid|3a,7a-Dihydroxy-5b,14a,17b-cholanate|
[H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]1([H])CC[C@]3(C)[C@]([H])(CC[C@@]3([H])[C@]1([H])[C@H](O)C2)[C@H](C)CCC(O)=O
",,,CHEBI:16755,,,,,,,,,,,,,,,,,,,,,,,CHEBI:16755,,,,,chenodeoxycholic acid|Chenodeoxycholic acid,,CHEBI:16755,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4051,"[""alveolar rhabdomyosarcoma""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_3247,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4051,,,DOID:4382,NCI:C7958|NCI:C3749|UMLS_CUI:C0206655|MESH:D018232|OMIM:268220|UMLS_CUI:C0279613|SNOMEDCT_US_2016_03_01:63449009|SNOMEDCT_US_2016_03_01:404053004,alveolar childhood rhabdomyosarcoma|pediatric Alveolar Rhabdomyosarcoma|Alveolar Rhabdomyosarcoma|Alveolar rhabdomyosarcoma (disorder)|Alveolar rhabdomyosarcoma (morphologic abnormality),,disease_ontology,,DOID:4051,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,alveolar rhabdomyosarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217474,"[""3-ketosteroid receptors gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00200002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217474,,,,,,,,,,,,,,,,,,,,,,,,,,,,3-ketosteroid receptors gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200570,"[""OR4C5 gene""]",,"An olfactory receptor 4C5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4C5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200570,,,,,,,,,,,,,,,,79346,OR4C5,,,,,,,,,,,OR4C5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400272,"[""GSK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400159,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400272,,,,,,,,,,,,,,,,,,,,,,,,,,,,GSK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000980,"[""oviduct""]",,Either of a pair of slender ducts through which ova pass from the ovaries to the uterus in the female reproductive system of humans and higher mammals.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003099,,,,,,,,Either of a pair of slender ducts through which ova pass from the ovaries to the uterus in the female reproductive system of humans and higher mammals.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000980,,,,,,,BrendaTissueOBO,salpinx|uterine tube|tuba uterinae|tuba uterina|fallopian tube,BTO:0000980,,,,,,,,,,,,,,,,,,,oviduct,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200124,"[""GCGR gene""]",,"A glucagon receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47871] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400047,,,,,,,,"A glucagon receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47871] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200124,,,,,,,,,,,,,,,,2642,GCGR,,,,,,,,,,,GCGR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100429,"[""Serine/threonine-protein kinase n3""]",,"A serine/threonine-protein kinase N3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6P5Z2] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300210,,,,,,,,"A serine/threonine-protein kinase N3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6P5Z2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100429,,,,https://pharos.nih.gov/idg/targets/Q6P5Z2,,,,,,,,,,,,,PKN3,PKNBETA,,Q6P5Z2,,,,,,,,Serine/threonine-protein kinase n3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2871,"[""endometrial carcinoma""]",,A endometrial cancer that is located_in the tissue lining the uterus.,false,,,http://purl.obolibrary.org/obo/DOID_1380|http://purl.obolibrary.org/obo/DOID_305,,,,,,,,A endometrial cancer that is located_in the tissue lining the uterus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2871,,,DOID:3000,SNOMEDCT_US_2016_03_01:30289006|UMLS_CUI:C0206687|SNOMEDCT_US_2016_03_01:254878006|NCI:C7558|UMLS_CUI:C0476089|MESH:D018269|SNOMEDCT_US_2016_03_01:93781006|SNOMEDCT_US_2016_03_01:269600001|NCI:C3769|SNOMEDCT_US_2016_03_01:154526001|MESH:D016889,endometrioid carcinoma|endometrioid carcinoma of female Reproductive system|carcinoma of the Endometrium,,disease_ontology,,DOID:2871,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,endometrial carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200364,"[""OR2AJ1 gene""]",,"An olfactory receptor 2AJ1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2AJ1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200364,,,,,,,,,,,,,,,,127608,OR2AJ1,OR2AJ1P,,,,,,,,,,OR2AJ1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200516,"[""TAOK3 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400318,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200516,,,,,,,,,,,,,,,,51347,TAOK3,DPK|JIK|KDS,,,,,,,,,,TAOK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200796,"[""TAS2R5 gene""]",,"A taste receptor type 2 member 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400014,,,,,,,,"A taste receptor type 2 member 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200796,,,,,,,,,,,,,,,,54429,TAS2R5,,,,,,,,,,,TAS2R5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200092,"[""EMR4P gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200092,,,,,,,,,,,,,,,,326342,EMR4P,EMR4|GPR127|PGR16,,,,,,,,,,EMR4P gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100606,"[""NAD kinase 2, mitochondrial""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100606,,,,,,,,,,,,,,,,,NADK2,,,Q4G0N4,,,,,,,,"NAD kinase 2, mitochondrial",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1595,"[""endogenous depression""]",,A mental depression that is characterized by a dysregulation of the endogenous opioid system and not of the monaminergic system.,false,,,http://purl.obolibrary.org/obo/DOID_1470,,,,,,,,A mental depression that is characterized by a dysregulation of the endogenous opioid system and not of the monaminergic system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1595,,,DOID:6340,SNOMEDCT_US_2016_03_01:191599006|NCI:C35094|NCI:C34532|SNOMEDCT_US_2016_03_01:154873003|UMLS_CUI:C0011573|SNOMEDCT_US_2016_03_01:231498003|UMLS_CUI:C0041696|MESH:D003866|OMIM:608516|EFO:0003761|SNOMEDCT_US_2016_03_01:300706003,unipolar depression|clinical depression,,disease_ontology,,DOID:1595,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,endogenous depression,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1029,"[""familial periodic paralysis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_896,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1029,,,,SNOMEDCT_US_2016_03_01:54696002|UMLS_CUI:C0030443|SNOMEDCT_US_2016_03_01:155099000|MESH:D010245|ICD10CM:G72.3|SNOMEDCT_US_2016_03_01:193241004|NCI:C84709|SNOMEDCT_US_2016_03_01:267607008|SNOMEDCT_US_2016_03_01:267714003,,,disease_ontology,,DOID:1029,,,,,,,,,,,,,,,,,,,familial periodic paralysis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9663,"[""aphthous stomatitis""]",,A stomatitis characterized by the repeated formation of benign and non-contagious mouth ulcers.,false,,,http://purl.obolibrary.org/obo/DOID_9637,,,,,,,,A stomatitis characterized by the repeated formation of benign and non-contagious mouth ulcers.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9663,,,,SNOMEDCT_US_2016_03_01:110426005|SNOMEDCT_US_2016_03_01:321258009|SNOMEDCT_US_2016_03_01:196534000|ICD9CM:528.2|SNOMEDCT_US_2016_03_01:427617000|MESH:D013281|UMLS_CUI:C0038363|SNOMEDCT_US_2016_03_01:303117009|NCI:C62546|SNOMEDCT_US_2016_03_01:398870000|SNOMEDCT_US_2016_03_01:367526005|SNOMEDCT_US_2016_03_01:196529004|SNOMEDCT_US_2016_03_01:83312008|SNOMEDCT_US_2016_03_01:426965005|SNOMEDCT_US_2016_03_01:322224003|SNOMEDCT_US_2016_03_01:155661008|SNOMEDCT_US_2016_03_01:196536003,Aphthous ulceration (disorder)|oral ulcer|Aphtha (morphologic abnormality)|Oral aphthae|Canker sore,,disease_ontology,Oral aphthous ulcer,DOID:9663,,,,,,,,,,,,,,,,,,,aphthous stomatitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3905,"[""lung carcinoma""]",,A lung cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is located_in the lungs and has_symptom cough and has_symptom chest discomfort or pain and has_symptom weight loss and has_symptom hemoptysis.,false,,,http://purl.obolibrary.org/obo/DOID_305|http://purl.obolibrary.org/obo/DOID_1324,,,,,,,,A lung cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is located_in the lungs and has_symptom cough and has_symptom chest discomfort or pain and has_symptom weight loss and has_symptom hemoptysis.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3905,,,,UMLS_CUI:C0684249|EFO:0001071|ICD10CM:C34.90|SNOMEDCT_US_2016_03_01:154485001|SNOMEDCT_US_2016_03_01:269561006|NCI:C4878|SNOMEDCT_US_2016_03_01:187875007,cancer of lung,,disease_ontology,carcinoma of lung,DOID:3905,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,lung carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200035,"[""AURKA gene""]",,"The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400130,,,,,,,,"The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200035,,,,,,,,,,,,,,,,6790,AURKA,AIK|AIRK1|ARK1,,,,,,,,,,AURKA gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100152,"[""Fibroblast growth factor receptor 4""]",,A fibroblast growth factor receptor 4 that is encoded in the genome of human. [PRO:CNA] |fibroblast growth factor receptor 4 (FGFR4)  with  no mutation  in a nonphosphorylated state,false,,,http://www.drugtargetontology.org/dto/DTO_03300158,,,,,,,,A fibroblast growth factor receptor 4 that is encoded in the genome of human. [PRO:CNA] |fibroblast growth factor receptor 4 (FGFR4)  with  no mutation  in a nonphosphorylated state,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100152,,,,https://pharos.nih.gov/idg/targets/P22455,,,,,,,,,,,,,FGFR4,JTK2|TKF,,P22455,,,,,,,,Fibroblast growth factor receptor 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100454,"[""Olfactory receptor 5au1""]",,"An olfactory receptor 5AU1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5AU1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100454,,,,https://pharos.nih.gov/idg/targets/Q8NGC0,,,,,,,,,,,,,OR5AU1,,,Q8NGC0,,,,,,,,Olfactory receptor 5au1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000800,"[""endoderm""]",,A germ layer lying remote from the surface of the embryo that gives rise to internal tissues such as gut.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000556,,,,,,,,A germ layer lying remote from the surface of the embryo that gives rise to internal tissues such as gut.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000800,,,,,,,BrendaTissueOBO,hypoblast,BTO:0000800,,,,,,,,,,,,,,,,,,,endoderm,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001343,"[""extensor digitorum communis""]",,A muscle on the back of the forearm that extends the fingers and wrist.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000151,,,,,,,,A muscle on the back of the forearm that extends the fingers and wrist.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001343,,,,,,,BrendaTissueOBO,,BTO:0001343,,,,,,,,,,,,,,,,,,,extensor digitorum communis,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200188,"[""GPR27 gene""]",,"A G-protein coupled receptor 27 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NS67] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 27 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NS67] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200188,,,,,,,,,,,,,,,,2850,GPR27,SREB1,,,,,,,,,,GPR27 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200112,"[""GABRA6 gene""]",,"GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400511,,,,,,,,"GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200112,,,,,,,,,,,,,,,,2559,GABRA6,,,,,,,,,,,GABRA6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300240,"[""TTK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300240,,,,,,,,,,,,,,,,,,,,,,,,,,,,TTK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200704,"[""OR8K1 gene""]",,"An olfactory receptor 8K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 8K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200704,,,,,,,,,,,,,,,,390157,OR8K1,,,,,,,,,,,OR8K1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200318,"[""MAPK6 gene""]",,"The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400292,,,,,,,,"The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200318,,,,,,,,,,,,,,,,5597,MAPK6,ERK3|PRKM6,,,,,,,,,,MAPK6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200685,"[""OR8A1 gene""]",,"An olfactory receptor 8A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 8A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200685,,,,,,,,,,,,,,,,390275,OR8A1,,,,,,,,,,,OR8A1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100598,"[""Olfactory receptor 4L1""]",,"An olfactory receptor 4L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH43] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH43] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100598,,,,https://pharos.nih.gov/idg/targets/Q8NH43,,,,,,,,,,,,,OR4L1,OR4L2P,,Q8NH43,,,,,,,,Olfactory receptor 4L1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001974,"[""HPEC cell""]",,Vascular endothelial cell line from human placenta.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001973|http://purl.obolibrary.org/obo/BTO_0001975,,,,,,,,Vascular endothelial cell line from human placenta.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001974,,,,,,,BrendaTissueOBO,,BTO:0001974,,,,,,,,,,,,,,,,,,,HPEC cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100081,"[""Chloride intracellular channel protein 3""]",,"A chloride intracellular channel protein 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95833] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300342,,,,,,,,"A chloride intracellular channel protein 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95833] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100081,,,,https://pharos.nih.gov/idg/targets/O95833,,,,,,,,,,,,,CLIC3,,,O95833,,,,,,,,Chloride intracellular channel protein 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100494,"[""Olfactory receptor 1J4""]",,"An olfactory receptor 1J4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1J4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100494,,,,https://pharos.nih.gov/idg/targets/Q8NGS1,,,,,,,,,,,,,OR1J4,,,Q8NGS1,,,,,,,,Olfactory receptor 1J4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005078,"[""foot sole""]",,The underside of the foot.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The underside of the foot.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005078,XPMUser,2011-03-07T07:37:10Z,,,,,BrendaTissueOBO,,BTO:0005078,,,,,,,,,,,,,,,,,,,foot sole,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4123,"[""nail disease""]",,An integumentary system disease that is located_in nail.,false,,,http://purl.obolibrary.org/obo/DOID_16,,,,,,,,An integumentary system disease that is located_in nail.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4123,,,,SNOMEDCT_US_2016_03_01:17790008|ICD10CM:L60.9|ICD9CM:703.9|SNOMEDCT_US_2016_03_01:156401005|ICD10CM:L60|ICD9CM:703|MESH:D009260|SNOMEDCT_US_2016_03_01:267861009|UMLS_CUI:C0027339|SNOMEDCT_US_2016_03_01:201127007,,,disease_ontology,,DOID:4123,,,,,,,,,,,,,,,,,,,nail disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_3306,"[""calcitonin""]","InChI=1S/C145H240N44O48S2/c1-65(2)45-86(175-139(232)110(70(11)12)183-136(229)99-63-239-238-62-79(148)117(210)178-96(59-191)134(227)174-92(52-104(151)202)131(224)172-90(49-69(9)10)129(222)180-98(61-193)135(228)187-114(74(16)197)142(235)181-99)118(211)158-55-106(204)162-80(25-18-20-40-146)120(213)169-89(48-68(7)8)128(221)179-97(60-192)133(226)167-83(34-37-102(149)200)122(215)165-85(36-39-109(207)208)123(216)171-88(47-67(5)6)127(220)173-91(51-77-54-156-64-161-77)130(223)164-81(26-19-21-41-147)121(214)170-87(46-66(3)4)126(219)166-84(35-38-103(150)201)125(218)186-113(73(15)196)141(234)177-94(50-76-30-32-78(199)33-31-76)143(236)189-44-24-29-101(189)137(230)168-82(27-22-42-157-145(154)155)124(217)185-112(72(14)195)140(233)176-93(53-105(152)203)132(225)184-111(71(13)194)138(231)160-56-107(205)163-95(58-190)119(212)159-57-108(206)182-115(75(17)198)144(237)188-43-23-28-100(188)116(153)209/h30-33,54,64-75,79-101,110-115,190-199H,18-29,34-53,55-63,146-148H2,1-17H3,(H2,149,200)(H2,150,201)(H2,151,202)(H2,152,203)(H2,153,209)(H,156,161)(H,158,211)(H,159,212)(H,160,231)(H,162,204)(H,163,205)(H,164,223)(H,165,215)(H,166,219)(H,167,226)(H,168,230)(H,169,213)(H,170,214)(H,171,216)(H,172,224)(H,173,220)(H,174,227)(H,175,232)(H,176,233)(H,177,234)(H,178,210)(H,179,221)(H,180,222)(H,181,235)(H,182,206)(H,183,229)(H,184,225)(H,185,217)(H,186,218)(H,187,228)(H,207,208)(H4,154,155,157)/t71-,72-,73-,74-,75-,79+,80+,81+,82+,83+,84+,85+,86+,87+,88+,89+,90+,91+,92+,93+,94+,95+,96+,97+,98+,99+,100+,101+,110+,111+,112+,113+,114+,115+/m1/s1|calcitonin|Salmon calcitonin-(1-32)|3429.713|Calcitonin, salmon|Thyrocalcitonin (salmon)|cyclo-[Cys-Ser-Asn-Leu-Ser-Thr-Cys]-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2|Salmotonin|3431.85300|C145H240N44O48S2|Salmon calcitonin|BBBFJLBPOGFECG-VJVYQDLKSA-N|0|Cibacalcin|CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(N)=O",A 32-membered heterodetic cyclic peptide comprising the sequence Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2 cyclised by a disulfide bridge between the two Cys residues at positions 1 and 7.,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:D00249|CAS:47931-85-1|KEGG:C06865|DrugBank:DB00017|Drug_Central:2989|Reaxys:8186880|CAS:9007-12-9|Wikipedia:Calcitonin,A 32-membered heterodetic cyclic peptide comprising the sequence Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2 cyclised by a disulfide bridge between the two Cys residues at positions 1 and 7.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,"N-{[(4R,7S,10S,13S,16S,19S,22R)-22-amino-16-(2-amino-2-oxoethyl)-7-[(1R)-1-hydroxyethyl]-10,19-bis(hydroxymethyl)-13-isobutyl-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20-hexaazacyclotricosan-4-yl]carbonyl}-L-valyl-L-leucylglycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-alpha-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-asparaginyl-L-threonylglycyl-L-serylglycyl-L-threonyl-L-prolinamide|Calcitonin",,chebi_ontology,"InChI=1S/C145H240N44O48S2/c1-65(2)45-86(175-139(232)110(70(11)12)183-136(229)99-63-239-238-62-79(148)117(210)178-96(59-191)134(227)174-92(52-104(151)202)131(224)172-90(49-69(9)10)129(222)180-98(61-193)135(228)187-114(74(16)197)142(235)181-99)118(211)158-55-106(204)162-80(25-18-20-40-146)120(213)169-89(48-68(7)8)128(221)179-97(60-192)133(226)167-83(34-37-102(149)200)122(215)165-85(36-39-109(207)208)123(216)171-88(47-67(5)6)127(220)173-91(51-77-54-156-64-161-77)130(223)164-81(26-19-21-41-147)121(214)170-87(46-66(3)4)126(219)166-84(35-38-103(150)201)125(218)186-113(73(15)196)141(234)177-94(50-76-30-32-78(199)33-31-76)143(236)189-44-24-29-101(189)137(230)168-82(27-22-42-157-145(154)155)124(217)185-112(72(14)195)140(233)176-93(53-105(152)203)132(225)184-111(71(13)194)138(231)160-56-107(205)163-95(58-190)119(212)159-57-108(206)182-115(75(17)198)144(237)188-43-23-28-100(188)116(153)209/h30-33,54,64-75,79-101,110-115,190-199H,18-29,34-53,55-63,146-148H2,1-17H3,(H2,149,200)(H2,150,201)(H2,151,202)(H2,152,203)(H2,153,209)(H,156,161)(H,158,211)(H,159,212)(H,160,231)(H,162,204)(H,163,205)(H,164,223)(H,165,215)(H,166,219)(H,167,226)(H,168,230)(H,169,213)(H,170,214)(H,171,216)(H,172,224)(H,173,220)(H,174,227)(H,175,232)(H,176,233)(H,177,234)(H,178,210)(H,179,221)(H,180,222)(H,181,235)(H,182,206)(H,183,229)(H,184,225)(H,185,217)(H,186,218)(H,187,228)(H,207,208)(H4,154,155,157)/t71-,72-,73-,74-,75-,79+,80+,81+,82+,83+,84+,85+,86+,87+,88+,89+,90+,91+,92+,93+,94+,95+,96+,97+,98+,99+,100+,101+,110+,111+,112+,113+,114+,115+/m1/s1|calcitonin|Salmon calcitonin-(1-32)|3429.713|Calcitonin, salmon|Thyrocalcitonin (salmon)|cyclo-[Cys-Ser-Asn-Leu-Ser-Thr-Cys]-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2|Salmotonin|3431.85300|C145H240N44O48S2|Salmon calcitonin|BBBFJLBPOGFECG-VJVYQDLKSA-N|0|Cibacalcin|CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(N)=O",,,CHEBI:3306,,,,,,,,,,,,,,,,,,,,,,,CHEBI:3306,,,,,calcitonin,,CHEBI:3306,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200330,"[""TRPM5 gene""]",,"This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele. [provided by RefSeq, Oct 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400587,,,,,,,,"This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele. [provided by RefSeq, Oct 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200330,,,,,,,,,,,,,,,,29850,TRPM5,LTRPC5|MTR1,,,,,,,,,,TRPM5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100293,"[""Mitogen-activated protein kinase kinase kinase kinase 1""]",,"mitogen-activated protein kinase kinase kinase kinase 1 (M4K1)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase kinase kinase kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92918] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300287,,,,,,,,"mitogen-activated protein kinase kinase kinase kinase 1 (M4K1)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase kinase kinase kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92918] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100293,,,,https://pharos.nih.gov/idg/targets/Q92918,,,,,,,,,,,,,MAP4K1,HPK1,,Q92918,,,,,,,,Mitogen-activated protein kinase kinase kinase kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003110,"[""CALO cell""]",,HPV18 positive human uterine cervix carcinoma cell line; established from stage IIB squamous cell cervical carcinoma explants from Mexican female at the National University of Mexico.,false,,,http://purl.obolibrary.org/obo/BTO_0001967|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,HPV18 positive human uterine cervix carcinoma cell line; established from stage IIB squamous cell cervical carcinoma explants from Mexican female at the National University of Mexico.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003110,,,,,,,BrendaTissueOBO,,BTO:0003110,,,,,,,,,,,,,,,,,,,CALO cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5688,"[""Werner syndrome""]",,"An autosomal recessive disease characterized by premature aging and age-related phenotypes such as atherosclerosis, arteriosclerosis, cataracts, osteoporosis, soft tissue calcification, premature thinning, graying, and loss of hair, as well as a high incidence of some types of cancers. In 90% of the cases it is that has material basis in mutations in the WRN gene, on chromosome 8.",false,,,http://purl.obolibrary.org/obo/DOID_0050737,,,,,,,,"An autosomal recessive disease characterized by premature aging and age-related phenotypes such as atherosclerosis, arteriosclerosis, cataracts, osteoporosis, soft tissue calcification, premature thinning, graying, and loss of hair, as well as a high incidence of some types of cancers. In 90% of the cases it is that has material basis in mutations in the WRN gene, on chromosome 8.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5688,,,,ORDO:902|SNOMEDCT_US_2016_03_01:190590004|OMIM:277700|UMLS_CUI:C0043119|SNOMEDCT_US_2016_03_01:190592007|SNOMEDCT_US_2016_03_01:51626007|NCI:C3447|MESH:D014898,Werner's syndrome|adult progeria|adult premature ageing syndrome|WS,,disease_ontology,,DOID:5688,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,Werner syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100394,"[""Serine/threonine-protein kinase pdik1l""]",,"A serine/threonine-protein kinase PDIK1L that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N165] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300202,,,,,,,,"A serine/threonine-protein kinase PDIK1L that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N165] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100394,,,,https://pharos.nih.gov/idg/targets/Q8N165,,,,,,,,,,,,,PDIK1L,CLIK1L,,Q8N165,,,,,,,,Serine/threonine-protein kinase pdik1l,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000124,"[""microspore""]",,Haploid cells produced by meiosis in the anthers of angiosperms; four microspores are produced from a single microsporocyte.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Haploid cells produced by meiosis in the anthers of angiosperms; four microspores are produced from a single microsporocyte.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000124,,,,,,,BrendaTissueOBO,,BTO:0000124,,,,,,,,,,,,,,,,,,,microspore,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100163,"[""G protein-coupled receptor kinase 7""]",,"A G protein-coupled receptor kinase 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WTQ7] |G protein-coupled receptor kinase 7 (GRK7)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300271,,,,,,,,"A G protein-coupled receptor kinase 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WTQ7] |G protein-coupled receptor kinase 7 (GRK7)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100163,,,,https://pharos.nih.gov/idg/targets/Q8WTQ7,,,,,,,,,,,,,GRK7,GPRK7,,Q8WTQ7,,,,,,,,G protein-coupled receptor kinase 7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_53461,"[""Neuropeptide S""]",,,[1],,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:53461,,,,,,,,,,,,,,,,,,,,,,,CHEBI:53461,,,,,neuropeptide S|Neuropeptide S,1,CHEBI:53461,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001655,"[""male cone""]",,"In conifers, the reproductive parts are housed within the cones. A conifer has two kinds of cones, the pollen, or male, cone is the small and soft. A pollen cone has many tiny sporangia that produce pollen grains. The wind usually delivers the pollen grains from the pollen cone to the seed cone, this is the yellow haze often seen in the spring in coniferous forest areas.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000280,,,,,,,,"In conifers, the reproductive parts are housed within the cones. A conifer has two kinds of cones, the pollen, or male, cone is the small and soft. A pollen cone has many tiny sporangia that produce pollen grains. The wind usually delivers the pollen grains from the pollen cone to the seed cone, this is the yellow haze often seen in the spring in coniferous forest areas.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001655,,,,,,,BrendaTissueOBO,pollen cone,BTO:0001655,,,,,,,,,,,,,,,,,,,male cone,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3904,"[""bronchus carcinoma""]",,A bronchus cancer that has_material_basis_in epithelial cells.,false,,,http://purl.obolibrary.org/obo/DOID_305|http://purl.obolibrary.org/obo/DOID_1325,,,,,,,,A bronchus cancer that has_material_basis_in epithelial cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3904,,,,MESH:D002283|SNOMEDCT_US_2016_03_01:363493006|NCI:C35875|SNOMEDCT_US_2016_03_01:154485001|UMLS_CUI:C0007121|CSP:2017-6052|SNOMEDCT_US_2016_03_01:269561006|SNOMEDCT_US_2016_03_01:254622008,BC - Bronchogenic carcinoma,,disease_ontology,,DOID:3904,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,bronchus carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000164,"[""SEA""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_32952,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000164,,,,,,,,,,,,,,,,,,,,,,,,,,,,SEA,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001979,"[""mucous gland""]",,"A gland that secretes a slimy, chemically inert material.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000765,,,,,,,,"A gland that secretes a slimy, chemically inert material.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001979,,,,,,,BrendaTissueOBO,muciparous gland|glandula mucosa,BTO:0001979,,,,,,,,,,,,,,,,,,,mucous gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300110,"[""RGC group""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300102,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300110,,,,,,,,,,,,,,,,,,,,,,,,,,,,RGC group,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200496,"[""STK11 gene""]",,"This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400316,,,,,,,,"This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200496,,,,,,,,,,,,,,,,6794,STK11,LKB1|PJS,,,,,,,,,,STK11 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300026,"[""Bombesin receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300026,,,,,,,,,,,,,,,,,,,,,,,,,,,,Bombesin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000234,"[""vein""]",,Any of the tubular branching vessels that carry blood from the capillaries toward the heart.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001102,,,,,,,,Any of the tubular branching vessels that carry blood from the capillaries toward the heart.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000234,,,,,,,BrendaTissueOBO,venous vessel,BTO:0000234,,,,,,,,,,,,,,,,,,,vein,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100005,"[""C719 in EGFR(G719C)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100005,,,,,,,,,,,,,,,,,,,,,,,,,,,,C719 in EGFR(G719C),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200273,"[""NMBR gene""]",,"A neuromedin-B receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28336] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400026,,,,,,,,"A neuromedin-B receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28336] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200273,,,,,,,,,,,,,,,,4829,NMBR,,,,,,,,,,,NMBR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200020,"[""AKT2 gene""]",,"This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400121,,,,,,,,"This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200020,,,,,,,,,,,,,,,,208,AKT2,,,,,,,,,,,AKT2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200425,"[""OR52K1 gene""]",,"An olfactory receptor 52K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 52K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200425,,,,,,,,,,,,,,,,390036,OR52K1,,,,,,,,,,,OR52K1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100245,"[""Leucine-rich repeat-containing protein 26""]",,"A leucine-rich repeat-containing protein 26 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q2I0M4] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,"A leucine-rich repeat-containing protein 26 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q2I0M4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100245,,,,https://pharos.nih.gov/idg/targets/Q2I0M4,,,,,,,,,,,,,LRRC26,CAPC,,Q2I0M4,,,,,,,,Leucine-rich repeat-containing protein 26,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400389,"[""CACNA1I subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400333,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400389,,,,,,,,,,,,,,,,,,,,,,,,,,,,CACNA1I subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200076,"[""CXCR2 gene""]",,"A C-X-C chemokine receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25025] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400031,,,,,,,,"A C-X-C chemokine receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25025] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200076,,,,,,,,,,,,,,,,3579,CXCR2,IL8RB,,,,,,,,,,CXCR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1558,"[""angioedema""]",,"A skin disease characterized by the rapid swelling of the dermis, subcutaneous tissue, mucosa and submucosal tissues.",false,,,http://purl.obolibrary.org/obo/DOID_37,,,,,,,,"A skin disease characterized by the rapid swelling of the dermis, subcutaneous tissue, mucosa and submucosal tissues.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1558,,,,SNOMEDCT_US_2016_03_01:41291007|UMLS_CUI:C0002994|CSP:2716-7007|MESH:D000799|SNOMEDCT_US_2016_03_01:157756002|SNOMEDCT_US_2016_03_01:82966003|SNOMEDCT_US_2016_03_01:269433002|SNOMEDCT_US_2016_03_01:400075008|ICD10CM:T78.3|NCI:C112175,Quincke's edema|angioneurotic edema|Angioneurotic oedema|giant urticaria,,disease_ontology,,DOID:1558,,,,,,,,,,,,,,,,,,,angioedema,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004730,"[""myeloid progenitor cell""]",,"One of the two stem cells derived from hematopoietic stem cells, the other being the lymphoid progenitor cell. Derived from these myeloid progenitor cells are the erythroid progenitor cells and the myeloid cells.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"One of the two stem cells derived from hematopoietic stem cells, the other being the lymphoid progenitor cell. Derived from these myeloid progenitor cells are the erythroid progenitor cells and the myeloid cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004730,mgr,2010-08-20T09:34:28Z,,,,,BrendaTissueOBO,,BTO:0004730,,,,,,,,,,,,,,,,,,,myeloid progenitor cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200242,"[""PRKCE gene""]",,"Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400278,,,,,,,,"Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200242,,,,,,,,,,,,,,,,5581,PRKCE,PKCE,,,,,,,,,,PRKCE gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200350,"[""MYLK gene""]",,"This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400196,,,,,,,,"This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200350,,,,,,,,,,,,,,,,4638,MYLK,MLCK|MLCK1|MYLK1,,,,,,,,,,MYLK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000385,"[""RIPK4 kinase domain""]",,Receptor-interacting serine-threonine kinase 4; ANKK2; ANKRD3; DIK; MGC129992; MGC129993; PKK; RIP4,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Receptor-interacting serine-threonine kinase 4; ANKK2; ANKRD3; DIK; MGC129992; MGC129993; PKK; RIP4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000385,,,,,,,,,,,,,,,,,,,200379,,,,,,,,,RIPK4 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400268,"[""PEK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400151,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400268,,,,,,,,,,,,,,,,,,,,,,,,,,,,PEK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400162,"[""RCK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400111,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400162,,,,,,,,,,,,,,,,,,,,,,,,,,,,RCK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300180,"[""SYK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300180,,,,,,,,,,,,,,,,,,,,,,,,,,,,SYK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9201,"[""lichen planus""]",,"A lichen disease that is located_in skin, located_in tongue or located_in oral mucosa, which presents itself in the form of papules, lesions or rashes.",false,,,http://purl.obolibrary.org/obo/DOID_8574,,,,,,,,"A lichen disease that is located_in skin, located_in tongue or located_in oral mucosa, which presents itself in the form of papules, lesions or rashes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9201,,,,MESH:D008010|UMLS_CUI:C0023646|ICD9CM:697.0|ICD10CM:L43.9|SNOMEDCT_US_2016_03_01:201004002|SNOMEDCT_US_2016_03_01:156377007|NCI:C3189|SNOMEDCT_US_2016_03_01:4776004|ICD10CM:L43,"Lichen, ruber planus|lichen ruber planus",,disease_ontology,,DOID:9201,,,,,,,,,,,,,,,,,,,lichen planus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200624,"[""SHPK gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200624,,,,,,,,,,,,,,,,,,,,,,,,,,,,SHPK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13812,"[""adhesions of uterus""]",,,false,,,http://purl.obolibrary.org/obo/DOID_345,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13812,,,,SNOMEDCT_US_2016_03_01:367435001|SNOMEDCT_US_2016_03_01:31107007|SNOMEDCT_US_2016_03_01:361115000|SNOMEDCT_US_2016_03_01:301789000|UMLS_CUI:C0241593,Intrauterine adhesions|Band of uterus|Intrauterine synechiae,,disease_ontology,,DOID:13812,,,,,,,,,,,,,,,,,,,adhesions of uterus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200182,"[""IKBKB gene""]",,"The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400164,,,,,,,,"The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200182,,,,,,,,,,,,,,,,3551,IKBKB,IKKB,,,,,,,,,,IKBKB gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1508,"[""candidiasis""]",,"An opportunistic mycosis that involves fungal infection of the mouth, throat, skin, scalp, vagina, fingers, nails, bronchi, lungs, heart and brain by Candida species, of which Candida albicans is the most common. Systemic Candida infections are usually confined to severely immunocompromised persons.",false,,,http://purl.obolibrary.org/obo/DOID_2473,,,,,,,,"An opportunistic mycosis that involves fungal infection of the mouth, throat, skin, scalp, vagina, fingers, nails, bronchi, lungs, heart and brain by Candida species, of which Candida albicans is the most common. Systemic Candida infections are usually confined to severely immunocompromised persons.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1508,,,DOID:1507,SNOMEDCT_US_2016_03_01:187005005|NCI:C26711|UMLS_CUI:C0006840|ICD9CM:112|SNOMEDCT_US_2016_03_01:78048006|MESH:D002177|ICD10CM:B37.9|ICD10CM:B37|SNOMEDCT_US_2016_03_01:187024008|SNOMEDCT_US_2016_03_01:187478002|ICD9CM:112.9|SNOMEDCT_US_2016_03_01:154403005,Disseminated candidiasis|systemic candidiasis,,disease_ontology,,DOID:1508,,,,,,,,,,,,,,,,,,,candidiasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400028,"[""Calcitonin receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400003,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400028,,,,,,,,,,,,,,,,,,,,,,,,,,,,Calcitonin receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000538,"[""alveolar cell type II""]",,Pleomorphic cells of the pulmonary alveolar epithelium that secrete surfactant and are distinguished by abundant cytoplasm containing numerous lipid-rich multilamellar bodies.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000395,,,,,,,,Pleomorphic cells of the pulmonary alveolar epithelium that secrete surfactant and are distinguished by abundant cytoplasm containing numerous lipid-rich multilamellar bodies.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000538,,,,,,,BrendaTissueOBO,type 2 pneumocyte|T2 cell|alveolar type 2 cell |alveolar cell type 2|alveolar type II cell|alveolar T2 cell|granular pneumonocyte|large alveolar cell|great alveolar cell,BTO:0000538,,,,,,,,,,,,,,,,,,,alveolar cell type II,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3382,"[""liposarcoma""]",,A lipomatous cancer that arises in fat cells in deep soft tissue retroperitoneum.,false,,,http://purl.obolibrary.org/obo/DOID_1115|http://purl.obolibrary.org/obo/DOID_3939|http://purl.obolibrary.org/obo/DOID_8564,,,,,,,,A lipomatous cancer that arises in fat cells in deep soft tissue retroperitoneum.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3382,,,,SNOMEDCT_US_2016_03_01:189777004|NCI:C3194|SNOMEDCT_US_2016_03_01:49430005|MESH:D008080|UMLS_CUI:C0023827|SNOMEDCT_US_2016_03_01:254829001,,,disease_ontology,,DOID:3382,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,liposarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000734,"[""myelocyte""]",,A bone-marrow cell: especially: a motile cell with cytoplasmic granules that gives rise to the blood granulocytes and occurs abnormally in the circulating blood (as in myelogenous leukemia).,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A bone-marrow cell: especially: a motile cell with cytoplasmic granules that gives rise to the blood granulocytes and occurs abnormally in the circulating blood (as in myelogenous leukemia).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000734,,,,,,,BrendaTissueOBO,,BTO:0000734,,,,,,,,,,,,,,,,,,,myelocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002682,"[""inferior vena cava""]",,"The venous trunk for the lower extremities and for the pelvic and abdominal viscera; it begins at the level of the fifth lumbar vertebra by union of the common iliac veins, passes upward on the right of the aorta, and empties into the right atrium of the heart.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001438,,,,,,,,"The venous trunk for the lower extremities and for the pelvic and abdominal viscera; it begins at the level of the fifth lumbar vertebra by union of the common iliac veins, passes upward on the right of the aorta, and empties into the right atrium of the heart.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002682,,,,,,,BrendaTissueOBO,vena cava inferior,BTO:0002682,,,,,,,,,,,,,,,,,,,inferior vena cava,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000677,"[""plant tumor tissue""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000677,,,,,,,BrendaTissueOBO,,BTO:0000677,,,,,,,,,,,,,,,,,,,plant tumor tissue,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100051,"[""S719 in EGFR(G719S)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100051,,,,,,,,,,,,,,,,,,,,,,,,,,,,S719 in EGFR(G719S),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000630,"[""inner ear""]",,"The essential organ of hearing and equilibrium that is located in the temporal bone, is innervated by the auditory nerve, and includes the vestibule, the semicircular canals, and the cochlea.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The essential organ of hearing and equilibrium that is located in the temporal bone, is innervated by the auditory nerve, and includes the vestibule, the semicircular canals, and the cochlea.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000630,,,,,,,BrendaTissueOBO,internal ear|auris interna,BTO:0000630,,,,,,,,,,,,,,,,,,,inner ear,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80324,"[""RFamide-related peptide 3""]",RFRP-3,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16110,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,RFRP-3,,,CHEBI:80324,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80324,,,,,RFamide-related peptide 3,,CHEBI:80324,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200085,"[""CHKB gene""]",,"Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus. [provided by RefSeq, Jun 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03491029,,,,,,,,"Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus. [provided by RefSeq, Jun 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200085,,,,,,,,,,,,,,,,1120,CHKB,CHETK|CHKL,,,,,,,,,,CHKB gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200327,"[""MAPK15 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400295,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200327,,,,,,,,,,,,,,,,225689,MAPK15,ERK7|ERK8,,,,,,,,,,MAPK15 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400304,"[""PAKB subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400187,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400304,,,,,,,,,,,,,,,,,,,,,,,,,,,,PAKB subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80311,"[""Neurokinin A""]","Substance K|
CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)O)C(C)C)C(N)=O
|C50H80N14O14S|HEAUFJZALFKPBA-YRVBCFNBSA-N|Neuromedin L|
InChI=1S/C50H80N14O14S/c1-26(2)18-34(45(73)58-32(42(53)70)15-17-79-6)57-38(67)23-55-49(77)40(27(3)4)63-47(75)35(19-29-12-8-7-9-13-29)60-48(76)37(24-65)62-46(74)36(21-39(68)69)61-50(78)41(28(5)66)64-44(72)33(14-10-11-16-51)59-43(71)31(52)20-30-22-54-25-56-30/h7-9,12-13,22,25-28,31-37,40-41,65-66H,10-11,14-21,23-24,51-52H2,1-6H3,(H2,53,70)(H,54,56)(H,55,77)(H,57,67)(H,58,73)(H,59,71)(H,60,76)(H,61,78)(H,62,74)(H,63,75)(H,64,72)(H,68,69)/t28?,31-,32-,33-,34-,35-,36-,37-,40-,41-/m0/s1
",A polypeptide that has formula C50H80N14O14S.,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG COMPOUND:C16097,A polypeptide that has formula C50H80N14O14S.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,"Substance K|
CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)O)C(C)C)C(N)=O
|C50H80N14O14S|HEAUFJZALFKPBA-YRVBCFNBSA-N|Neuromedin L|
InChI=1S/C50H80N14O14S/c1-26(2)18-34(45(73)58-32(42(53)70)15-17-79-6)57-38(67)23-55-49(77)40(27(3)4)63-47(75)35(19-29-12-8-7-9-13-29)60-48(76)37(24-65)62-46(74)36(21-39(68)69)61-50(78)41(28(5)66)64-44(72)33(14-10-11-16-51)59-43(71)31(52)20-30-22-54-25-56-30/h7-9,12-13,22,25-28,31-37,40-41,65-66H,10-11,14-21,23-24,51-52H2,1-6H3,(H2,53,70)(H,54,56)(H,55,77)(H,57,67)(H,58,73)(H,59,71)(H,60,76)(H,61,78)(H,62,74)(H,63,75)(H,64,72)(H,68,69)/t28?,31-,32-,33-,34-,35-,36-,37-,40-,41-/m0/s1
",,,CHEBI:80311,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80311,,,,,Neurokinin A,,CHEBI:80311,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200503,"[""OR1N2 gene""]",,"An olfactory receptor 1N2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1N2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200503,,,,,,,,,,,,,,,,138882,OR1N2,,,,,,,,,,,OR1N2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200037,"[""AGTR2 gene""]",,"An angiotensin II receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P50052] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400023,,,,,,,,"An angiotensin II receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P50052] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200037,,,,,,,,,,,,,,,,186,AGTR2,,,,,,,,,,,AGTR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491018,"[""Thymidylate kinase family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400326,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491018,,,,,,,,,,,,,,,,,,,,,,,,,,,,Thymidylate kinase family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300412,"[""GRIA3 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300412,,,,,,,,,,,,,,,,,,,,,,,,,,,,GRIA3 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_628,"[""combined T cell and B cell immunodeficiency""]",,"A primary immunodeficiency disease that involves multiple components of the immune system, including both humoral immunity and cell-mediated immunity.",false,,,http://purl.obolibrary.org/obo/DOID_612,,,,,,,,"A primary immunodeficiency disease that involves multiple components of the immune system, including both humoral immunity and cell-mediated immunity.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:628,,,,NCI:C27871|OMIM:312863|UMLS_CUI:C0494261|ICD10CM:D81.9|SNOMEDCT_US_2016_03_01:191003005|ICD9CM:279.2|ICD10CM:D81|ORDO:101972,X-linked combined immunodeficiency|Congenital Combined Immunodeficiency|combined immunodeficiency,,disease_ontology,,DOID:628,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,combined T cell and B cell immunodeficiency,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_627,"[""severe combined immunodeficiency""]",,A combined T cell and B cell immunodeficiency that is caused by a defect in several genes encoding for B and T lymphocytes resulting in individuals with non-functional immune systems.,false,,,http://purl.obolibrary.org/obo/DOID_628,,,,,,,,A combined T cell and B cell immunodeficiency that is caused by a defect in several genes encoding for B and T lymphocytes resulting in individuals with non-functional immune systems.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:627,,,,SNOMEDCT_US_2016_03_01:31323000|UMLS_CUI:C0085110|SNOMEDCT_US_2016_03_01:190994004|NCI:C3472|MESH:D016511,combined T and B cell inborn immunodeficiency|SCID,,disease_ontology,,DOID:627,,,,,,,,,,,,,,,,,,,severe combined immunodeficiency,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_62,"[""aortic valve disease""]",,Updating out dated UMLS CUI.,false,,,http://purl.obolibrary.org/obo/DOID_4079,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:62,,,DOID:56,ICD9CM:424.1|SNOMEDCT_US_2016_03_01:8722008|NCI:C78650|UMLS_CUI:C1260873|MESH:C563178|SNOMEDCT_US_2016_03_01:194988001|ICD9CM:395,,,disease_ontology,,DOID:62,,,,,,,,,,,,,,,,,Updating out dated UMLS CUI.,,aortic valve disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_626,"[""complement deficiency""]",,"A primary immunodeficiency disease that is the result in a mutation of a gene encoding one of the thirty complement system proteins, produced predominantly in liver, which function to defend against infection and produce inflammation.",false,,,http://purl.obolibrary.org/obo/DOID_612,,,,,,,,"A primary immunodeficiency disease that is the result in a mutation of a gene encoding one of the thirty complement system proteins, produced predominantly in liver, which function to defend against infection and produce inflammation.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:626,,,,SNOMEDCT_US_2016_03_01:24743004|NCI:C4691|SNOMEDCT_US_2016_03_01:191014008|UMLS_CUI:C0272242|ICD10CM:D80-D89|ICD10CM:D84.1,Complement deficiency disease (disorder)|Complement deficiency,,disease_ontology,,DOID:626,,,,,,,,,,,,,,,,,,,complement deficiency,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000178,"[""adenoma cell""]",,A benign epithelial tumor cell in which the cells form recognizable glandular structures or in which the cells are clearly derived from glandular epithelium.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000415,,,,,,,,A benign epithelial tumor cell in which the cells form recognizable glandular structures or in which the cells are clearly derived from glandular epithelium.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000178,,,,,,,BrendaTissueOBO,,BTO:0000178,,,,,,,,,,,,,,,,,,,adenoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002305,"[""scolex""]",,The anterior organ of a tapeworm used for attachment to host tissues.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001262,,,,,,,,The anterior organ of a tapeworm used for attachment to host tissues.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002305,,,,,,,BrendaTissueOBO,holdfast,BTO:0002305,,,,,,,,,,,,,,,,,,,scolex,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000309,"[""THR205 in TNK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000309,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR205 in TNK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9794,"[""hereditary choroidal atrophy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_980,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9794,,,,UMLS_CUI:C0154893|ICD9CM:363.50|SNOMEDCT_US_2016_03_01:74469006|SNOMEDCT_US_2016_03_01:193465004|ICD10CM:H31.2|SNOMEDCT_US_2016_03_01:193473008|ICD9CM:363.5|ICD10CM:H31.20,,,disease_ontology,,DOID:9794,,,,,,,,,,,,,,,,,,,hereditary choroidal atrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2710,"[""sick building syndrome""]",,"An extrinsic allergic alveolitis that is characterized by a set of symptoms such as headache, fatigue, eye irritation, and breathing difficulties that affect workers in modern airtight office buildings. The disease is caused by indoor pollutants (as formaldehyde fumes, particulate matter, or microorganisms), and the symptoms tend to disappear when affected individuals leave the building.",false,,,http://purl.obolibrary.org/obo/DOID_841,,,,,,,,"An extrinsic allergic alveolitis that is characterized by a set of symptoms such as headache, fatigue, eye irritation, and breathing difficulties that affect workers in modern airtight office buildings. The disease is caused by indoor pollutants (as formaldehyde fumes, particulate matter, or microorganisms), and the symptoms tend to disappear when affected individuals leave the building.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2710,,,,MESH:D018877|SNOMEDCT_US_2016_03_01:19076009|UMLS_CUI:C0037050,,,disease_ontology,,DOID:2710,,,,,,,,,,,,,,,,,,,sick building syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200286,"[""RYR3 gene""]",,"The protein encoded by this gene is a ryanodine receptor, which functions to release calcium from intracellular storage for use in many cellular processes. For example, the encoded protein is involved in skeletal muscle contraction by releasing calcium from the sarcoplasmic reticulum followed by depolarization of T-tubules. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400462,,,,,,,,"The protein encoded by this gene is a ryanodine receptor, which functions to release calcium from intracellular storage for use in many cellular processes. For example, the encoded protein is involved in skeletal muscle contraction by releasing calcium from the sarcoplasmic reticulum followed by depolarization of T-tubules. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200286,,,,,,,,,,,,,,,,6263,RYR3,HBRR,,,,,,,,,,RYR3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000643,"[""intestinal muscle""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001260,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000643,,,,,,,BrendaTissueOBO,intestinal smooth muscle,BTO:0000643,,,,,,,,,,,,,,,,,,,intestinal muscle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300507,"[""GABRA2 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300507,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRA2 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100029,"[""Alpha-1D adrenergic receptor""]",,"An alpha-1D adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25100] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300093,,,,,,,,"An alpha-1D adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25100] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100029,,,,https://pharos.nih.gov/idg/targets/P25100,,,,,,,,,,,,,ADRA1D,ADRA1A,,P25100,,,,,,,,Alpha-1D adrenergic receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100154,"[""Probable G-protein coupled receptor 151""]",,"A G-protein coupled receptor 151 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDV0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 151 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDV0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100154,,,,https://pharos.nih.gov/idg/targets/Q8TDV0,,,,,,,,,,,,,GPR151,PGR7,,Q8TDV0,,,,,,,,Probable G-protein coupled receptor 151,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000232,"[""cerebellum""]",,"A large dorsally projecting part of the brain concerned especially with the coordination of muscles and the maintenance of bodily equilibrium, situated between the brain stem and the back of the cerebrum , and formed in humans of two lateral lobes and a median lobe.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A large dorsally projecting part of the brain concerned especially with the coordination of muscles and the maintenance of bodily equilibrium, situated between the brain stem and the back of the cerebrum , and formed in humans of two lateral lobes and a median lobe.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000232,,,,,,,BrendaTissueOBO,,BTO:0000232,,,,,,,,,,,,,,,,,,,cerebellum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001065,"[""Tsu-Pr1 cell""]",,Human prostate epithelial carcinoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001033,,,,,,,,Human prostate epithelial carcinoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001065,,,,,,,BrendaTissueOBO,,BTO:0001065,,,,,,,,,,,,,,,,,,,Tsu-Pr1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100133,"[""Ephrin type-a receptor 10""]",,"An ephrin type-A receptor 10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5JZY3] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300153,,,,,,,,"An ephrin type-A receptor 10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5JZY3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100133,,,,https://pharos.nih.gov/idg/targets/Q5JZY3,,,,,,,,,,,,,EPHA10,,,Q5JZY3,,,,,,,,Ephrin type-a receptor 10,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3315,"[""lipoma""]",,A cell type benign neoplasm that is composed of lipocytes.,false,,,http://purl.obolibrary.org/obo/DOID_0060084,,,,,,,,A cell type benign neoplasm that is composed of lipocytes.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3315,,,DOID:3154|DOID:9291,SNOMEDCT_US_2016_03_01:93163002|ICD9CM:214|NCI:C4248|NCI:C3192|MESH:D018205|SNOMEDCT_US_2016_03_01:115227001|SNOMEDCT_US_2016_03_01:154612003|SNOMEDCT_US_2016_03_01:46720004|UMLS_CUI:C0206631|UMLS_CUI:C0023798|SNOMEDCT_US_2016_03_01:254830006|SNOMEDCT_US_2016_03_01:189785008|OMIM:151900|SNOMEDCT_US_2016_03_01:189018005|NCI:C4502|SNOMEDCT_US_2016_03_01:254831005|ICD9CM:214.9|SNOMEDCT_US_2016_03_01:189776008|MESH:D008067|UMLS_CUI:C0346118|ICD10CM:D17.9|SNOMEDCT_US_2016_03_01:254827004|ICD10CM:D17,"Lipomatous tumor|multiple lipomatosis|tumor of adipose tissue (disorder)|Lipomatous neoplasm (morphologic abnormality)|LIPOMATOSIS, FAMILIAL MULTIPLE|benign tumor of Adipose tissue|benign lipomatous tumor",,disease_ontology,,DOID:3315,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,lipoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9065,"[""leishmaniasis""]",,"A parasitic protozoa infectious disease that involves infection caused by protozoan parasite of the genus Leishmania, which is transmitted by the bite of sand fly (subfamily Phlebotominae).",false,,,http://purl.obolibrary.org/obo/DOID_2789,,,,,,,,"A parasitic protozoa infectious disease that involves infection caused by protozoan parasite of the genus Leishmania, which is transmitted by the bite of sand fly (subfamily Phlebotominae).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9065,,,DOID:9136,ICD9CM:085.9|MESH:D007896|ICD10CM:B55|ICD10CM:B55.9|SNOMEDCT_US_2016_03_01:266206004|UMLS_CUI:C0023281|SNOMEDCT_US_2016_03_01:187511000|SNOMEDCT_US_2016_03_01:186811002|SNOMEDCT_US_2016_03_01:154377009|NCI:C34767|SNOMEDCT_US_2016_03_01:80612004|ICD9CM:085,,,disease_ontology,post-kala-azar dermal infectious disease by leishmaniasis|Post Kala-Azar Dermal Leishmaniasis|Post-kala-azar dermal leishmaniasis,DOID:9065,http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,leishmaniasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200198,"[""KCNE3 gene""]",,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. A missense mutation in this gene is associated with hypokalemic periodic paralysis. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400445,,,,,,,,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. A missense mutation in this gene is associated with hypokalemic periodic paralysis. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200198,,,,,,,,,,,,,,,,10008,KCNE3,,,,,,,,,,,KCNE3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000037,"[""LEU1161 in MST1R""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000037,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU1161 in MST1R,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400552,"[""Kv6.4/KCNG4 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400447,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400552,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv6.4/KCNG4 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000065,"[""CAMK2G kinase domain""]",,Calcium/calmodulin-dependent protein kinase II gamma; CAMK; CAMK2G; CAMKG; CAMK-II; FLJ16043; MGC26678,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Calcium/calmodulin-dependent protein kinase II gamma; CAMK; CAMK2G; CAMKG; CAMK-II; FLJ16043; MGC26678,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000065,,,,,,,,,,,,,,,,,,,200066,,,,,,,,,CAMK2G kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2815,"[""cranial nerve malignant neoplasm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_338,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2815,,,,ICD9CM:192.0|NCI:C3571|UMLS_CUI:C0153644|SNOMEDCT_US_2016_03_01:93767009|ICD10CM:C72.50|SNOMEDCT_US_2016_03_01:188307009|SNOMEDCT_US_2016_03_01:188311003|MESH:D003390,malignant neoplasm of cranial nerves NOS (disorder)|malignant tumor of cranial nerve (disorder)|malignant neoplasm of cranial nerves|malignant tumor of the Cranial nerve|malignant neoplasm of cranial nerve,,disease_ontology,,DOID:2815,,,,,,,,,,,,,,,,,,,cranial nerve malignant neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02390004,"[""Peptidic GPCR""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300001,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02390004,,,,,,,,,,,,,,,,,,,,,,,,,,,,Peptidic GPCR,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300016,"[""Vomeronasal receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300016,,,,,,,,,,,,,,,,,,,,,,,,,,,,Vomeronasal receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100608,"[""Olfactory receptor 4s2""]",,"An olfactory receptor 4S2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH73] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4S2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH73] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100608,,,,https://pharos.nih.gov/idg/targets/Q8NH73,,,,,,,,,,,,,OR4S2,OR4S2P,,Q8NH73,,,,,,,,Olfactory receptor 4s2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400060,"[""Hydroxycarboxylic acid receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400060,,,,,,,,,,,,,,,,,,,,,,,,,,,,Hydroxycarboxylic acid receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8670,"[""eating disorder""]",,A specific developmental disorder that is characterized by abnormal eating habits that may involve either insufficient or excessive food intake to the detriment of an individual's physical and emotional health.,false,,,http://purl.obolibrary.org/obo/DOID_0060038,,,,,,,,A specific developmental disorder that is characterized by abnormal eating habits that may involve either insufficient or excessive food intake to the detriment of an individual's physical and emotional health.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8670,,,,UMLS_CUI:C0013473|ICD10CM:F50.9|SNOMEDCT_US_2016_03_01:192444003|SNOMEDCT_US_2016_03_01:72366004|SNOMEDCT_US_2016_03_01:192452000|NCI:C89332|ICD10CM:F50|ICD9CM:307.50,,,disease_ontology,,DOID:8670,,,,,,,,,,,,,,,,,,,eating disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11294,"[""arteriovenous malformation""]",,An anomalous configuration of blood vessels that shunts arterial blood directly into veins by bypassing the capillary system.,false,,,http://purl.obolibrary.org/obo/DOID_255,,,,,,,,An anomalous configuration of blood vessels that shunts arterial blood directly into veins by bypassing the capillary system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11294,,,,SNOMEDCT_US_2016_03_01:204480002|CSP:0571-2717|HP:0100026|UMLS_CUI:C0334533|NCI:C2882|SNOMEDCT_US_2016_03_01:14156004|SNOMEDCT_US_2016_03_01:11071001|SNOMEDCT_US_2016_03_01:233982006|SNOMEDCT_US_2016_03_01:403966009|ICD10CM:I77.0,Arteriovenous hemangioma (disorder)|Racemose hemangioma (morphologic abnormality)|Racemose aneurysm (morphologic abnormality)|Racemose Angioma|Cirsoid aneurysm,,disease_ontology,,DOID:11294,,,,,,,,,,,,,,,,,,,arteriovenous malformation,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100310,"[""Olfactory receptor 10H4""]",,"An olfactory receptor 10H4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10H4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGA5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100310,,,,https://pharos.nih.gov/idg/targets/Q8NGA5,,,,,,,,,,,,,OR10H4,,,Q8NGA5,,,,,,,,Olfactory receptor 10H4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000303,"[""crown gall""]",,A disease that affects many species of plants and is caused by a bacterium (Agrobacterium tumefaciens) which forms tumorous enlargements just below the ground on the stem.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000677,,,,,,,,A disease that affects many species of plants and is caused by a bacterium (Agrobacterium tumefaciens) which forms tumorous enlargements just below the ground on the stem.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000303,,,,,,,BrendaTissueOBO,,BTO:0000303,,,,,,,,,,,,,,,,,,,crown gall,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001190,"[""root nodule""]",,Gall-like structures on the roots of legumes that contain symbiotic nitrogen-fixing bacteria.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Gall-like structures on the roots of legumes that contain symbiotic nitrogen-fixing bacteria.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001190,,,,,,,BrendaTissueOBO,root tubercle|nodule,BTO:0001190,,,,,,,,,,,,,,,,,,,root nodule,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002024,"[""squamous cell carcinoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002024,,,,,,,BrendaTissueOBO,SCC cell line,BTO:0002024,,,,,,,,,,,,,,,,,,,squamous cell carcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200509,"[""OR2A2 gene""]",,"An olfactory receptor 2A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF42] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF42] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200509,,,,,,,,,,,,,,,,442361,OR2A2,OR2A17P|OR2A2P,,,,,,,,,,OR2A2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000444,"[""fat pad""]",,An accumulation of adipose tissue (fat cells) enclosed in fibrous tissue.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001487,,,,,,,,An accumulation of adipose tissue (fat cells) enclosed in fibrous tissue.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000444,,,,,,,BrendaTissueOBO,,BTO:0000444,,,,,,,,,,,,,,,,,,,fat pad,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001076,"[""pituitary gland tumor cell""]",,"A benign tumor of the pituitary, the master gland that controls other glands and influences numerous body functions including growth. Although the tumor itself is not cancerous, it may affect pituitary function, and therefore may need to be removed.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A benign tumor of the pituitary, the master gland that controls other glands and influences numerous body functions including growth. Although the tumor itself is not cancerous, it may affect pituitary function, and therefore may need to be removed.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001076,,,,,,,BrendaTissueOBO,pituitary tumor cell|pituitary adenoma cell,BTO:0001076,,,,,,,,,,,,,,,,,,,pituitary gland tumor cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3039,"[""cecum adenocarcinoma""]",,A cecum carcinoma that derives_from epithelial cells of glandular origin.,false,,,http://purl.obolibrary.org/obo/DOID_1519|http://purl.obolibrary.org/obo/DOID_0050913,,,,,,,,A cecum carcinoma that derives_from epithelial cells of glandular origin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3039,,,,SNOMEDCT_US_2016_03_01:413446001|NCI:C5543|UMLS_CUI:C1332866,Cecal adenocarcinoma|adenocarcinoma of cecum (disorder),,disease_ontology,adenocarcinoma of cecum,DOID:3039,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,cecum adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01390002,"[""Cation-transporting ion channel""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01390002,,,,,,,,,,,,,,,,,,,,,,,,,,,,Cation-transporting ion channel,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80327,"[""Cholecystokinin-8""]",CCK-8,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16114,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,CCK-8,,,CHEBI:80327,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80327,,,,,Cholecystokinin-8,,CHEBI:80327,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000054,"[""LEU139 in PLK3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000054,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU139 in PLK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100467,"[""Scy1-like protein 2""]",,"A SCY1-like protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6P3W7] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300199,,,,,,,,"A SCY1-like protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6P3W7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100467,,,,https://pharos.nih.gov/idg/targets/Q6P3W7,,,,,,,,,,,,,SCYL2,CVAK104|KIAA1360,,Q6P3W7,,,,,,,,Scy1-like protein 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000393,"[""endothelium""]",,An epithelium of mesodermal origin composed of a single layer of thin flattened cells that lines internal body cavities.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000416,,,,,,,,An epithelium of mesodermal origin composed of a single layer of thin flattened cells that lines internal body cavities.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000393,,,,,,,BrendaTissueOBO,,BTO:0000393,,,,,,,,,,,,,,,,,,,endothelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100058,"[""C-C chemokine receptor type 6""]",,"A C-C chemokine receptor type 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51684] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300095,,,,,,,,"A C-C chemokine receptor type 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51684] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100058,,,,https://pharos.nih.gov/idg/targets/P51684,,,,,,,,,,,,,CCR6,CKRL3|CMKBR6|GPR29|STRL22,,P51684,,,,,,,,C-C chemokine receptor type 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000160,"[""FGFR3 kinase domain""]",,Fibroblast growth factor receptor 3; ACH; CD333; CEK2; FGFR3; HSFGFR3EX; JTK4,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Fibroblast growth factor receptor 3; ACH; CD333; CEK2; FGFR3; HSFGFR3EX; JTK4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000160,,,,,,,,,,,,,,,,,,,200163,,,,,,,,,FGFR3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000394,"[""THR790 in EGFR""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000394,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR790 in EGFR,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000196,"[""MET722 in M3K6""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000196,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET722 in M3K6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000339,"[""THR315 in ABL1(Y253F)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000339,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR315 in ABL1(Y253F),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200792,"[""TAS2R60 gene""]",,"A taste receptor type 2 member 60 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59551] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400014,,,,,,,,"A taste receptor type 2 member 60 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59551] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200792,,,,,,,,,,,,,,,,338398,TAS2R60,,,,,,,,,,,TAS2R60 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400329,"[""Calcium-dependent chloride channel (ca-clc) family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400329,,,,,,,,,,,,,,,,,,,,,,,,,,,,Calcium-dependent chloride channel (ca-clc) family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004672,"[""hair shaft""]",,"The non-growing portion of a hair which protrudes from the skin, i.e., from the follicle.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The non-growing portion of a hair which protrudes from the skin, i.e., from the follicle.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004672,mgr,2010-05-10T12:51:05Z,,,,,BrendaTissueOBO,scapus pili,BTO:0004672,,,,,,,,,,,,,,,,,,,hair shaft,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200005,"[""HTR3E gene""]",,"This locus encodes a 5-hydroxytryptamine (serotonin) receptor subunit. The encoded protein, subunit E, may play a role in neurotransmission in myenteric neurons. Genes encoding subunits C, D and E form a cluster on chromosome 3. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01409932,,,,,,,,"This locus encodes a 5-hydroxytryptamine (serotonin) receptor subunit. The encoded protein, subunit E, may play a role in neurotransmission in myenteric neurons. Genes encoding subunits C, D and E form a cluster on chromosome 3. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200005,,,,,,,,,,,,,,,,285242,HTR3E,,,,,,,,,,,HTR3E gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300067,"[""Neuromedin U receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300067,,,,,,,,,,,,,,,,,,,,,,,,,,,,Neuromedin U receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217544,"[""NR1H3 gene""]",,"The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_00217465,,,,,,,,"The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217544,,,,,,,,,,,,,,,,10062,NR1H3,LXRA,,,,,,,,,,NR1H3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2394,"[""ovarian cancer""]",,A female reproductive organ cancer that is located_in the ovary.,false,,,http://purl.obolibrary.org/obo/DOID_120,,,,,,,,A female reproductive organ cancer that is located_in the ovary.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2394,,,DOID:9595|DOID:0060070|DOID:2144,ORDO:213517|SNOMEDCT_US_2016_03_01:123843001|MESH:D010051|SNOMEDCT_US_2016_03_01:363443007|SNOMEDCT_US_2016_03_01:154528000|SNOMEDCT_US_2016_03_01:372117006|OMIM:607893|NCI:C4984|OMIM:167000|ICD9CM:183.0|ICD10CM:C56|UMLS_CUI:C0919267|UMLS_CUI:C1299247|UMLS_CUI:C1140680|NCI:C7431|SNOMEDCT_US_2016_03_01:93934004,tumor of the Ovary|ovarian neoplasm|malignant Ovarian tumor|malignant tumour of ovary|ovary neoplasm|primary ovarian cancer,,disease_ontology,,DOID:2394,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,ovarian cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117519,"[""Progesterone receptor""]",,"A progesterone receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P06401] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117474,,,,,,,,"A progesterone receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P06401] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117519,,,,https://pharos.nih.gov/idg/targets/P06401,,,,,,,,,,,,,PGR,,,P06401,,,,,,,,Progesterone receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100042,"[""B1 bradykinin receptor""]",,"A B1 bradykinin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46663] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300025,,,,,,,,"A B1 bradykinin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46663] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100042,,,,https://pharos.nih.gov/idg/targets/P46663,,,,,,,,,,,,,BDKRB1,BRADYB1,,P46663,,,,,,,,B1 bradykinin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8553,"[""pyoderma gangrenosum""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4223,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8553,,,,MESH:D017511|SNOMEDCT_US_2016_03_01:74578003|ICD10CM:L88|ICD9CM:686.01|UMLS_CUI:C0085652,Pyoderma gangrenosum (disorder),,disease_ontology,,DOID:8553,,,,,,,,,,,,,,,,,,,pyoderma gangrenosum,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8736,"[""smallpox""]",,"A viral infectious disease that results_in infection located_in skin, has_material_basis_in Variola virus, which is transmitted_by droplets from oral, nasal or pharyngeal mucosa, transmitted_by contact with the body fluids, or transmitted_by fomites. The infection results_in_formation_of lesions, first on the face, hands and forearms and later on the trunk.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in infection located_in skin, has_material_basis_in Variola virus, which is transmitted_by droplets from oral, nasal or pharyngeal mucosa, transmitted_by contact with the body fluids, or transmitted_by fomites. The infection results_in_formation_of lesions, first on the face, hands and forearms and later on the trunk.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8736,,,,SNOMEDCT_US_2016_03_01:154344005|MESH:D012899|SNOMEDCT_US_2016_03_01:186505008|ICD9CM:050.9|UMLS_CUI:C0037354|SNOMEDCT_US_2016_03_01:67924001|ICD9CM:050|SNOMEDCT_US_2016_03_01:47452006|NCI:C35027|SNOMEDCT_US_2016_03_01:266193008|ICD10CM:B03,Ordinary smallpox,,disease_ontology,,DOID:8736,,,,,,,,,,,,,,,,,,,smallpox,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10264,"[""mumps""]",,"A viral infectious disease that results_in inflammation located_in salivary gland, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom fever, has_symptom headache, has_symptom muscle aches, has_symptom tiredness, has_symptom loss of appetite, has_symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in inflammation located_in salivary gland, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom fever, has_symptom headache, has_symptom muscle aches, has_symptom tiredness, has_symptom loss of appetite, has_symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10264,,,,ICD9CM:072|SNOMEDCT_US_2016_03_01:186652008|UMLS_CUI:C0026780|SNOMEDCT_US_2016_03_01:240526004|NCI:C29888|MESH:D009107|SNOMEDCT_US_2016_03_01:36989005|ICD10CM:B26.9|ICD10CM:B26|SNOMEDCT_US_2016_03_01:154352008|SNOMEDCT_US_2016_03_01:186651001,,,disease_ontology,,DOID:10264,,,,,,,,,,,,,,,,,,,mumps,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100190,"[""Interleukin-1 receptor-associated kinase 1""]",,An interleukin-1 receptor-associated kinase 1 encoded in the genome of human. [PRO:CNA] |interleukin-1 receptor-associated kinase 1 (IRAK1)  with  no mutation  in a nonphosphorylated state,false,,,http://www.drugtargetontology.org/dto/DTO_03300166,,,,,,,,An interleukin-1 receptor-associated kinase 1 encoded in the genome of human. [PRO:CNA] |interleukin-1 receptor-associated kinase 1 (IRAK1)  with  no mutation  in a nonphosphorylated state,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100190,,,,https://pharos.nih.gov/idg/targets/P51617,,,,,,,,,,,,,IRAK1,IRAK,,P51617,,,,,,,,Interleukin-1 receptor-associated kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1134,"[""gingival recession""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1483,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1134,,,DOID:13280|DOID:13901|DOID:2405|DOID:1133,ICD9CM:523.21|ICD9CM:523.22|ICD9CM:523.24|UMLS_CUI:C0017572|UMLS_CUI:C1456172|UMLS_CUI:C1456173|ICD10CM:K06.0|SNOMEDCT_US_2016_03_01:196360003|SNOMEDCT_US_2016_03_01:4356008|ICD9CM:523.2|SNOMEDCT_US_2016_03_01:155645006|MESH:D005889|UMLS_CUI:C1456171|SNOMEDCT_US_2016_03_01:59898000|UMLS_CUI:C0266916|NCI:C82068|ICD9CM:523.20|ICD9CM:523.23,"severe gingival recession|moderate gingival recession|minimal gingival recession|Gingival recession (disorder)|localized gingival recession (disorder)|Gingival recession, localized|Gingival recession|Gingival recession, unspecified|Gingival recession NOS (disorder)|localized gingival recession",,disease_ontology,,DOID:1134,,,,,,,,,,,,,,,,,,,gingival recession,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200301,"[""MAPKAPK5 gene""]",,"The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400289,,,,,,,,"The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200301,,,,,,,,,,,,,,,,8550,MAPKAPK5,PRAK,,,,,,,,,,MAPKAPK5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200317,"[""MAPK4 gene""]",,"Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus and phosphorylate nuclear targets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400292,,,,,,,,"Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus and phosphorylate nuclear targets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200317,,,,,,,,,,,,,,,,5596,MAPK4,ERK4|PRKM4,,,,,,,,,,MAPK4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100749,"[""Prokineticin receptor 1""]",,"A prokineticin receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TCW9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A prokineticin receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TCW9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100749,,,,https://pharos.nih.gov/idg/targets/Q8TCW9,,,,,,,,,,,,,PROKR1,GPR73|PKR1,,Q8TCW9,,,,,,,,Prokineticin receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003210,"[""papillary thyroid cancer cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001610,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003210,,,,,,,BrendaTissueOBO,,BTO:0003210,,,,,,,,,,,,,,,,,,,papillary thyroid cancer cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100638,"[""Olfactory receptor 5M8""]",,"An olfactory receptor 5M8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5M8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100638,,,,https://pharos.nih.gov/idg/targets/Q8NGP6,,,,,,,,,,,,,OR5M8,,,Q8NGP6,,,,,,,,Olfactory receptor 5M8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000395,"[""alveolar cell""]",,Any cell of the walls of the pulmonary alveoli; the term is often limited to alveolar epithelial cells (type I and type II alveolar cells) and alveolar macrophages.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Any cell of the walls of the pulmonary alveoli; the term is often limited to alveolar epithelial cells (type I and type II alveolar cells) and alveolar macrophages.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000395,,,,,,,BrendaTissueOBO,pneumonocyte|pneumocyte,BTO:0000395,,,,,,,,,,,,,,,,,,,alveolar cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100336,"[""Olfactory receptor 11L1""]",,"An olfactory receptor 11L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 11L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100336,,,,https://pharos.nih.gov/idg/targets/Q8NGX0,,,,,,,,,,,,,OR11L1,,,Q8NGX0,,,,,,,,Olfactory receptor 11L1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000157,"[""MET279 in BMPR2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000157,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET279 in BMPR2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200358,"[""NEK4 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400197,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200358,,,,,,,,,,,,,,,,6787,NEK4,STK2,,,,,,,,,,NEK4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10507,"[""Dressler's syndrome""]",,"A pericarditis characterized by inflammation, occurring after injury, located_in pericardium.",false,,,http://purl.obolibrary.org/obo/DOID_1787,,,,,,,,"A pericarditis characterized by inflammation, occurring after injury, located_in pericardium.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10507,,,,UMLS_CUI:C0152107|ICD10CM:I24.1|ICD9CM:411.0|SNOMEDCT_US_2016_03_01:66189004,Postmyocardial infarction syndrome|Postmyocardial infarction syndrome (disorder)|Dressler syndrome,,disease_ontology,,DOID:10507,,,,,,,,,,,,,,,,,,,Dressler's syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200197,"[""KCNE2 gene""]",,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400445,,,,,,,,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200197,,,,,,,,,,,,,,,,9992,KCNE2,,,,,,,,,,,KCNE2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02402006,"[""5-HT7 receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400017,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02402006,,,,,,,,,,,,,,,,,,,,,,,,,,,,5-HT7 receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001760,"[""myotube""]",,A developmental stage of a muscle fiber composed of a syncytium formed by fusion of myoblasts.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A developmental stage of a muscle fiber composed of a syncytium formed by fusion of myoblasts.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001760,,,,,,,BrendaTissueOBO,,BTO:0001760,,,,,,,,,,,,,,,,,,,myotube,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100378,"[""Olfactory receptor 4a47""]",,"An olfactory receptor 4A47 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF82] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4A47 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF82] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100378,,,,https://pharos.nih.gov/idg/targets/Q6IF82,,,,,,,,,,,,,OR4A47,,,Q6IF82,,,,,,,,Olfactory receptor 4a47,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002035,"[""U-251 MG cell""]",,Human glioma cell line. Morphology: glial; Species: human; Tumor: glioma.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000711,,,,,,,,Human glioma cell line. Morphology: glial; Species: human; Tumor: glioma.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002035,,,,,,,BrendaTissueOBO,U251 cell|U-251MG cell|U251MG cell|U-251 cell,BTO:0002035,,,,,,,,,,,,,,,,,,,U-251 MG cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217560,"[""NR2F6 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00217471,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217560,,,,,,,,,,,,,,,,2063,NR2F6,EAR2|ERBAL2,,,,,,,,,,NR2F6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005071,"[""PC3-MM2 cell""]",,Human prostate cancer cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human prostate cancer cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005071,XPMUser,2011-03-07T04:47:27Z,,,,,BrendaTissueOBO,,BTO:0005071,,,,,,,,,,,,,,,,,,,PC3-MM2 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100035,"[""Beta-3 adrenergic receptor""]",,"A beta-3 adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P13945] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300094,,,,,,,,"A beta-3 adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P13945] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100035,,,,https://pharos.nih.gov/idg/targets/P13945,,,,,,,,,,,,,ADRB3,ADRB3R|B3AR,,P13945,,,,,,,,Beta-3 adrenergic receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002883,"[""32D clone3 cell""]",,Mouse bone marrow cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Mouse bone marrow cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002883,,,,,,,BrendaTissueOBO,32D.cl3 cell|32D CL3 cell|32D/cl3 cell|32Dcl3 cell,BTO:0002883,,,,,,,,,,,,,,,,,,,32D clone3 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000020,"[""Cytokine domain of tyrosyl tRNA synthetase""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000020,,,,,,,,,,,,,,,,,,,,,,,,,,,,Cytokine domain of tyrosyl tRNA synthetase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005588,"[""peg cell""]",,"A peg cell is a non-ciliated epithelial cell within the uterine tube. It is also called an intercalary cell or secretory cell. It is one of the two epithelial cells of the fallopian tube, along with ciliated simple columnar epithelial cells.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A peg cell is a non-ciliated epithelial cell within the uterine tube. It is also called an intercalary cell or secretory cell. It is one of the two epithelial cells of the fallopian tube, along with ciliated simple columnar epithelial cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005588,Marion,2014-03-06T09:37:10Z,,,,,BrendaTissueOBO,secretory oviduct cell|non-ciliated oviduct cell|intercalary oviduct cell,BTO:0005588,,,,,,,,,,,,,,,,,,,peg cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200267,"[""LIMK1 gene""]",,"There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400283,,,,,,,,"There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200267,,,,,,,,,,,,,,,,3984,LIMK1,LIMK,,,,,,,,,,LIMK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400116,"[""CAMKL family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400116,,,,,,,,,,,,,,,,,,,,,,,,,,,,CAMKL family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000468,"[""ZAP70 kinase domain""]",,Tyrosine-protein kinase ZAP-70; Zeta-chain (TCR) associated protein kinase 70kDa; FLJ17670; FLJ17679; SRK; STD; TZK; ZAP70; ZAP-70,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Tyrosine-protein kinase ZAP-70; Zeta-chain (TCR) associated protein kinase 70kDa; FLJ17670; FLJ17679; SRK; STD; TZK; ZAP70; ZAP-70,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000468,,,,,,,,,,,,,,,,,,,200469,,,,,,,,,ZAP70 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000084,"[""CCL28""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000084,,,,,,,,,,,,,,,,,,,,,,,,,,,,CCL28,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2115,"[""B cell deficiency""]",,A primary immunnodeficiency disease that is caused by a lack of infection-fighting antibody producing B cells (immunoglobulins) or B cells that are not functioning properly.,false,,,http://purl.obolibrary.org/obo/DOID_612,,,,,,,,A primary immunnodeficiency disease that is caused by a lack of infection-fighting antibody producing B cells (immunoglobulins) or B cells that are not functioning properly.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2115,,,DOID:6026,UMLS_CUI:C0154276|SNOMEDCT_US_2016_03_01:190982008|ICD9CM:279.03,Immunoglobulin heavy chain deficiency (disorder)|immunoglobulin heavy chain deletion|B cell (antibody) deficiencies,,disease_ontology,,DOID:2115,,,,,,,,,,,,,,,,,,,B cell deficiency,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400107,"[""TKL group gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400102,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400107,,,,,,,,,,,,,,,,,,,,,,,,,,,,TKL group gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100049,"[""R858 in EGFR(L858R)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100049,,,,,,,,,,,,,,,,,,,,,,,,,,,,R858 in EGFR(L858R),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000148,"[""MET196 in MP2K7""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000148,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET196 in MP2K7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100202,"[""Gtp:amp phosphotransferase ak3, mitochondrial""]",,"A GTP:AMP phosphotransferase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UIJ7] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391006,,,,,,,,"A GTP:AMP phosphotransferase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UIJ7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100202,,,,https://pharos.nih.gov/idg/targets/Q9UIJ7,,,,,,,,,,,,,AK3,AK3L1|AK6|AKL3L,,Q9UIJ7,,,,,,,,"Gtp:amp phosphotransferase ak3, mitochondrial",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050737,"[""autosomal recessive disease""]",,"An autosomal genetic disease that is characterized by the presence of two mutated copies of the gene, both of which must be present in order for the disease or trait to develop.",false,,,http://purl.obolibrary.org/obo/DOID_0050739,,,,,,,,"An autosomal genetic disease that is characterized by the presence of two mutated copies of the gene, both of which must be present in order for the disease or trait to develop.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050737,lschriml,2012-07-24T12:51:47Z,,,,,disease_ontology,,DOID:0050737,,,,,,,,,,,,,,,,,,,autosomal recessive disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050736,"[""autosomal dominant disease""]",,An autosomal genetic disease that is characterized by the presence of one disease-associated mutation of a gene which is sufficient to cause the disease.,false,,,http://purl.obolibrary.org/obo/DOID_0050739,,,,,,,,An autosomal genetic disease that is characterized by the presence of one disease-associated mutation of a gene which is sufficient to cause the disease.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050736,lschriml,2012-07-24T12:51:47Z,,,,,disease_ontology,,DOID:0050736,,,,,,,,,,,,,,,,,,,autosomal dominant disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050735,"[""X-linked disease""]",,A monogenic disease that has_material_basis_in muations in genes on the X chromosome.,false,,,http://purl.obolibrary.org/obo/DOID_0050177,,,,,,,,A monogenic disease that has_material_basis_in muations in genes on the X chromosome.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050735,lschriml,2012-07-24T12:47:31Z,,,,,disease_ontology,,DOID:0050735,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,X-linked disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050739,"[""autosomal genetic disease""]",,A monogenic disease that is has material basis in a mutation in a single gene on one of the non-sex chromosomes.,false,,,http://purl.obolibrary.org/obo/DOID_0050177,,,,,,,,A monogenic disease that is has material basis in a mutation in a single gene on one of the non-sex chromosomes.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050739,lschriml,2012-07-24T04:45:53Z,,,,,disease_ontology,,DOID:0050739,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,autosomal genetic disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000213,"[""MET90 in CSNK1A1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000213,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET90 in CSNK1A1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002507,"[""autonomic nervous system""]",,"The enteric, parasympathetic, and sympathetic nervous systems taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the central nervous system, especially the hypothalamus and the solitary nucleus, which receive information relayed from VISCERAL AFFERENTS; these and related central and sensory structures are sometimes (but not here) considered to be part of the autonomic nervous system itself.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The enteric, parasympathetic, and sympathetic nervous systems taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the central nervous system, especially the hypothalamus and the solitary nucleus, which receive information relayed from VISCERAL AFFERENTS; these and related central and sensory structures are sometimes (but not here) considered to be part of the autonomic nervous system itself.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002507,,,,,,,BrendaTissueOBO,,BTO:0002507,,,,,,,,,,,,,,,,,,,autonomic nervous system,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001119,"[""procambium""]",,The part of the primary meristem of a plant that forms cambium and primary vascular tissues.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The part of the primary meristem of a plant that forms cambium and primary vascular tissues.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001119,,,,,,,BrendaTissueOBO,,BTO:0001119,,,,,,,,,,,,,,,,,,,procambium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200017,"[""ACKR1 gene""]",,"A duffy antigen/chemokine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q16570] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400031,,,,,,,,"A duffy antigen/chemokine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q16570] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200017,,,,,,,,,,,,,,,,2532,ACKR1,DARC|FY|GPD,,,,,,,,,,ACKR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100215,"[""Calcium/calmodulin-dependent protein kinase type 1b""]",,"A calcium/calmodulin-dependent protein kinase type 1B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6P2M8] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300171,,,,,,,,"A calcium/calmodulin-dependent protein kinase type 1B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6P2M8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100215,,,,https://pharos.nih.gov/idg/targets/Q6P2M8,,,,,,,,,,,,,PNCK,,,Q6P2M8,,,,,,,,Calcium/calmodulin-dependent protein kinase type 1b,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060443,"[""corneal endothelial dystrophy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2566,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060443,elvira,2015-10-16T16:39:25Z,,,endothelial dystrophy,,disease_ontology,,DOID:0060443,,,,,,,,,,,,,,,,,,,corneal endothelial dystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060446,"[""X-linked endothelial corneal dystrophy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060443,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060446,elvira,2015-10-16T17:13:34Z,,OMIM:300779|MESH:C567587|ORDO:293621|ICD10CM:H18.5,XECD,,disease_ontology,,DOID:0060446,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,X-linked endothelial corneal dystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060442,"[""stromal dystrophy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2566,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060442,elvira,2015-10-16T16:39:25Z,,,,,disease_ontology,,DOID:0060442,,,,,,,,,,,,,,,,,,,stromal dystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060448,"[""Fleck corneal dystrophy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060442,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060448,elvira,2015-10-16T17:20:34Z,,OMIM:121850|UMLS_CUI:C1562113|MESH:C563256|SNOMEDCT_US_2016_03_01:417183007|ORDO:98970,Francois-Neetens speckled corneal dystrophy|FCD,,disease_ontology,,DOID:0060448,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,Fleck corneal dystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100164,"[""Probable g-protein coupled receptor 173""]",,"A G-protein coupled receptor 173 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NS66] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 173 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NS66] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100164,,,,https://pharos.nih.gov/idg/targets/Q9NS66,,,,,,,,,,,,,GPR173,SREB3,,Q9NS66,,,,,,,,Probable g-protein coupled receptor 173,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200331,"[""TRPM7 gene""]",,"The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_01400588,,,,,,,,"The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200331,,,,,,,,,,,,,,,,54822,TRPM7,CHAK1|LTRPC7,,,,,,,,,,TRPM7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1398,"[""parasitic infectious disease""]",,A disease by infectious agent that is carried out by a parasite which by definition is a pathogen that simultaneously injures and derives sustenance from its host.,false,,,http://purl.obolibrary.org/obo/DOID_0050117,,,,,,,,A disease by infectious agent that is carried out by a parasite which by definition is a pathogen that simultaneously injures and derives sustenance from its host.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1398,,,DOID:948|DOID:1396|DOID:3564|DOID:886|DOID:2293|DOID:9644|DOID:4191|DOID:13509|DOID:2922|DOID:11681|DOID:1494|DOID:9639|DOID:2114,SNOMEDCT_US_2016_03_01:57100005|SNOMEDCT_US_2016_03_01:193273005|NCI:C34587|ICD9CM:360.13|ICD10CM:H44.12|UMLS_CUI:C0014238,parasitemia|Ectoparasitic disease,,disease_ontology,,DOID:1398,,,,,,,,,,,,,,,,,,,parasitic infectious disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217469,"[""Testicular receptors gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00200002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217469,,,,,,,,,,,,,,,,,,,,,,,,,,,,Testicular receptors gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300572,"[""Kv8.1/KCNV1 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300451,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300572,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv8.1/KCNV1 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300015,"[""Taste 1 receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300004,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300015,,,,,,,,,,,,,,,,,,,,,,,,,,,,Taste 1 receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000383,"[""RIPK1 kinase domain""]",,Receptor-interacting serine/threonine-protein kinase 1; FLJ39204; RIP; RIP1; RIPK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Receptor-interacting serine/threonine-protein kinase 1; FLJ39204; RIP; RIP1; RIPK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000383,,,,,,,,,,,,,,,,,,,200377,,,,,,,,,RIPK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8632,"[""Kaposi's sarcoma""]",,"A connective tissue cancer that derives_from lymphatic endothelium, and derives_from spindle cells, results_in_formation_of vascular channels that fill with blood cells, has_material_basis_in Human herpesvirus 8 (HHV8).",false,,,http://purl.obolibrary.org/obo/DOID_201|http://purl.obolibrary.org/obo/DOID_3620,,,,,,,,"A connective tissue cancer that derives_from lymphatic endothelium, and derives_from spindle cells, results_in_formation_of vascular channels that fill with blood cells, has_material_basis_in Human herpesvirus 8 (HHV8).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8632,,,DOID:12767|DOID:12762|DOID:12766|DOID:12761|DOID:12778|DOID:12772|DOID:12775|DOID:12770|DOID:8631|DOID:12768|DOID:6480|DOID:12764|DOID:12774|DOID:7239|DOID:12776|DOID:12777|DOID:12771,NCI:C9087|NCI:C5842|NCI:C5529|UMLS_CUI:C1332265|SNOMEDCT_US_2016_03_01:190112000|UMLS_CUI:C0153561|UMLS_CUI:C1332847|SNOMEDCT_US_2016_03_01:188144002|UMLS_CUI:C0153565|ICD10CM:C46|ICD10CM:C46.5|UMLS_CUI:C0346935|UMLS_CUI:C0153562|NCI:C3551|UMLS_CUI:C1334457|ICD10CM:C46.0|SNOMEDCT_US_2016_03_01:255114007|ICD10CM:C46.1|ICD9CM:176.1|SNOMEDCT_US_2016_03_01:154604006|MESH:D012514|UMLS_CUI:C0153563|ICD10CM:C46.9|OMIM:148000|NCI:C4578|NCI:C5523|NCI:C3550|SNOMEDCT_US_2016_03_01:188483007|UMLS_CUI:C1333776|NCI:C27500|ICD9CM:176.9|UMLS_CUI:C1335372|SNOMEDCT_US_2016_03_01:188775002|NCI:C5706|UMLS_CUI:C0036220|SNOMEDCT_US_2016_03_01:109387004|SNOMEDCT_US_2016_03_01:255115008|SNOMEDCT_US_2016_03_01:109386008|ICD9CM:176|SNOMEDCT_US_2016_03_01:109385007|UMLS_CUI:C1333453|UMLS_CUI:C1335509|ICD9CM:176.4|SNOMEDCT_US_2016_03_01:109388009|UMLS_CUI:C1334318|UMLS_CUI:C0153560|UMLS_CUI:C1333744|SNOMEDCT_US_2016_03_01:109391009|NCI:C5363|ICD10CM:C46.2|SNOMEDCT_US_2016_03_01:188029000|ICD9CM:176.3|NCI:C5602|ICD10CM:C46.3|NCI:C4579|NCI:C6377|UMLS_CUI:C0346936|ICD9CM:176.2|ICD10CM:C46.4|NCI:C6749|SNOMEDCT_US_2016_03_01:109390005|UMLS_CUI:C0153564|ICD9CM:176.5|SNOMEDCT_US_2016_03_01:49937004|NCI:C7006|ICD9CM:176.0,"conjunctival Kaposi's sarcoma|Kaposi's sarcoma of penis|pulmonary Kaposi's sarcoma|soft tissue Kaposi's sarcoma|Kaposi's sarcoma of central nervous system|Kaposi's sarcoma of soft tissues (disorder)|gastric Kaposi's sarcoma|anal Kaposi's sarcoma|Kaposi's sarcoma of soft tissue (disorder)|Kaposi's sarcoma of gastrointestinal sites|Kaposi's sarcoma of the gallbladder|Conjunctival Kaposi's sarcoma|cardiac Kaposi's sarcoma|Kaposi's sarcoma of anus|Kaposi's sarcoma of cornea (disorder)|Kaposi's sarcoma of skin|Kaposi sarcoma|Kaposi's sarcoma of lymph nodes|Kaposi's sarcoma of the CNS|Palate Kaposi's sarcoma|Kaposi's sarcoma of Heart|Kaposi's sarcoma of lung (disorder)|Corneal Kaposi's sarcoma|Kaposi's sarcoma of lymph nodes (disorder)|prostate Kaposi's sarcoma|Kaposi's sarcoma of skin (disorder)|lymphadenopathic Kaposi's sarcoma|lymph node Kaposi's sarcoma|palate Kaposi's sarcoma|Kaposi's sarcoma of the prostate|Kaposi's sarcoma of conjunctiva (disorder)|Kaposi's sarcoma, skin|corneal Kaposi's sarcoma|gallbladder Kaposi's sarcoma|penis Kaposi's sarcoma|Kaposi's sarcoma, lung|intestinal Kaposi's sarcoma|cutaneous Kaposi's sarcoma|Kaposi's sarcoma of esophagus|Cutaneous Kaposi's sarcoma|central nervous system Kaposi's sarcoma|esophageal Kaposi's sarcoma|Kaposi's sarcoma of palate (disorder)",,disease_ontology,African lymphadenopathic Kaposi's sarcoma|Kaposi's sarcoma-associated herpesvirus (KSHV),DOID:8632,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Kaposi's sarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8102,"[""fetal adenoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_6204,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8102,,,,UMLS_CUI:C0334328|NCI:C4160|SNOMEDCT_US_2016_03_01:30301008,Microfollicular adenoma (morphologic abnormality),,disease_ontology,,DOID:8102,,,,,,,,,,,,,,,,,,,fetal adenoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200194,"[""GPR37 gene""]",,"A G-protein coupled receptor 37 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O15354] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 37 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O15354] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200194,,,,,,,,,,,,,,,,2861,GPR37,,,,,,,,,,,GPR37 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000322,"[""THR306 in FRK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000322,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR306 in FRK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050728,"[""glycogen metabolism disorder""]",,A carbohydrate metabolism disorder that is characterized by abnormal accumulation or depletion of liver glycogen.,false,,,http://purl.obolibrary.org/obo/DOID_2978,,,,,,,,A carbohydrate metabolism disorder that is characterized by abnormal accumulation or depletion of liver glycogen.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050728,lschriml,2012-07-13T10:42:54Z,,,,,disease_ontology,,DOID:0050728,,,,,,,,,,,,,,,,,,,glycogen metabolism disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050725,"[""tyrosinemia type II""]",,"A tyrosinemia that has_material_basis_in deficiency of hepatic tyrosine aminotransferase located_in the liver and is characterized by keratitis, painful palmoplantar hyperkeratosis, mental retardation, and elevated serum tyrosine levels.",false,,,http://purl.obolibrary.org/obo/DOID_37|http://purl.obolibrary.org/obo/DOID_9275,,,,,,,,"A tyrosinemia that has_material_basis_in deficiency of hepatic tyrosine aminotransferase located_in the liver and is characterized by keratitis, painful palmoplantar hyperkeratosis, mental retardation, and elevated serum tyrosine levels.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050725,lschriml,2012-06-13T03:09:31Z,,OMIM:276600,Richner-Hanhart syndrome|Oculocutaneous tyrosinemia,,disease_ontology,,DOID:0050725,,,,,,,,,,,,,,,,,,,tyrosinemia type II,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001575,"[""choriocarcinoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000807,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001575,,,,,,,BrendaTissueOBO,,BTO:0001575,,,,,,,,,,,,,,,,,,,choriocarcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000204,"[""JAK3(JH1domain-catalytic) kinase domain""]",,Tyrosine-protein kinase JAK3; Janus kinase 3; JAK-3; L-JAK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Tyrosine-protein kinase JAK3; Janus kinase 3; JAK-3; L-JAK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000204,,,,,,,,,,,,,,,,,,,200209,,,,,,,,,JAK3(JH1domain-catalytic) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5823,"[""pediatric lymphoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060058,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5823,,,,NCI:C5165|UMLS_CUI:C1332979,,,disease_ontology,,DOID:5823,,,,,,,,,,,,,,,,,,,pediatric lymphoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000298,"[""PHE97 in CDK11""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000298,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE97 in CDK11,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000459,"[""fibrosarcoma cell""]",,Fibrosarcoma is a malignant tumour derived from connective tissue fibroblast.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001622|http://purl.obolibrary.org/obo/BTO_0001207,,,,,,,,Fibrosarcoma is a malignant tumour derived from connective tissue fibroblast.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000459,,,,,,,BrendaTissueOBO,fibroblastic sarcoma cell,BTO:0000459,,,,,,,,,,,,,,,,,,,fibrosarcoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000224,"[""MET929 in JAK2(JH1domain-catalytic)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000224,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET929 in JAK2(JH1domain-catalytic),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100079,"[""Chloride intracellular channel protein 1""]",,"A chloride intracellular channel protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00299] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300342,,,,,,,,"A chloride intracellular channel protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00299] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100079,,,,https://pharos.nih.gov/idg/targets/O00299,,,,,,,,,,,,,CLIC1,G6|NCC27,,O00299,,,,,,,,Chloride intracellular channel protein 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050425,"[""restless legs syndrome""]",,"A central nervous system disease characterized by throbbing, pulling creeping or other unpleasant sensations in the legs and the irresistible urge to move them.",false,,,http://purl.obolibrary.org/obo/DOID_331,,,,,,,,"A central nervous system disease characterized by throbbing, pulling creeping or other unpleasant sensations in the legs and the irresistible urge to move them.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050425,,,,OMIM:610439|ICD10CM:G25.81|MESH:D012148|ICD9CM:333.94|NCI:C84501|OMIM:610438|EFO:0004270|OMIM:102300|SNOMEDCT_US_2016_03_01:393579008|UMLS_CUI:C0035258|SNOMEDCT_US_2016_03_01:32914008|OMIM:611242|OMIM:612853|OMIM:615197|OMIM:611185,Wittmaack-Ekbom syndrome|Willis-Ekbom disease|WED,,disease_ontology,,DOID:0050425,,,,,,,,,,,,,,,,,Xref MGI.,,restless legs syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050424,"[""familial adenomatous polyposis""]",,An autosomal dominant disease that is has material basis in mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.,false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,An autosomal dominant disease that is has material basis in mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050424,,,,SNOMEDCT_US_2016_03_01:72900001|UMLS_CUI:C0032580|SNOMEDCT_US_2016_03_01:188828009|MESH:D011125|UMLS_CUI:C2713443|OMIM:608456|OMIM:175100|SNOMEDCT_US_2016_03_01:154609001|SNOMEDCT_US_2016_03_01:70921007|SNOMEDCT_US_2016_03_01:269636003|NCI:C3339|SNOMEDCT_US_2016_03_01:423471004|UMLS_CUI:C2713442,adenomatous polyposis of the colon,,disease_ontology,,DOID:0050424,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,familial adenomatous polyposis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050428,"[""nonepidermolytic palmoplantar keratoderma""]",,"A palmoplantar keratosis characterized by a well-demarcated, symmetric keratoderma located_in palms and located_in soles.",false,,,http://purl.obolibrary.org/obo/DOID_3390,,,,,,,,"A palmoplantar keratosis characterized by a well-demarcated, symmetric keratoderma located_in palms and located_in soles.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050428,,,,OMIM:615735|SNOMEDCT_US_2016_03_01:81206005|SNOMEDCT_US_2016_03_01:400123002|SNOMEDCT_US_2016_03_01:205584004|UMLS_CUI:C0022584|ORDO:2337|MESH:D015776|OMIM:600962|UMLS_CUI:C3489771|SNOMEDCT_US_2016_03_01:28596004|NCI:C3147|OMIM:613000,diffuse nonepidermolytic palmomplantar keratoderma|Unna-Thost Syndrome|tylosis|Thost-Unna Syndrome,,disease_ontology,,DOID:0050428,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,nonepidermolytic palmoplantar keratoderma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050426,"[""Stevens-Johnson syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_37,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050426,,,,MESH:D013262|NCI:C79777|UMLS_CUI:C3658301|UMLS_CUI:C1274933|SNOMEDCT_US_2016_03_01:200919006|ICD10CM:L51.1|SNOMEDCT_US_2016_03_01:156362004|UMLS_CUI:C0014518|SNOMEDCT_US_2016_03_01:238819008|ICD9CM:695.15|SNOMEDCT_US_2016_03_01:403609001|NCI:C79484|EFO:0004276|ICD10CM:L51.2|UMLS_CUI:C0038325|UMLS_CUI:C3658302|ICD9CM:695.13|SNOMEDCT_US_2016_03_01:73442001|SNOMEDCT_US_2016_03_01:267848009|SNOMEDCT_US_2016_03_01:23067006,,,disease_ontology,,DOID:0050426,,,,,,,,,,,,,,,,,,,Stevens-Johnson syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050427,"[""xeroderma pigmentosum""]",,An autosomal recessive disease that is characterized by a deficiency in the ability to repair ultraviolet damage that has_material_basis_in autosomal recessive inheritance of DNA repair.,false,,,http://purl.obolibrary.org/obo/DOID_0050737,,,,,,,,An autosomal recessive disease that is characterized by a deficiency in the ability to repair ultraviolet damage that has_material_basis_in autosomal recessive inheritance of DNA repair.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050427,,,,NCI:C3452|MESH:D014983|UMLS_CUI:C0043346|SNOMEDCT_US_2016_03_01:44600005|ICD10CM:Q82.1,,,disease_ontology,,DOID:0050427,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,xeroderma pigmentosum,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300295,"[""Erk7 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300191,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300295,,,,,,,,,,,,,,,,,,,,,,,,,,,,Erk7 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000354,"[""PIK4CB kinase domain""]",,"Phosphatidylinositol 4-kinase, catalytic, beta; NPIK; PI4K92; PI4KB; PI4KBETA; PI4K-BETA; PI4KIIIBETA; PIK4CB",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Phosphatidylinositol 4-kinase, catalytic, beta; NPIK; PI4K92; PI4KB; PI4KBETA; PI4K-BETA; PI4KIIIBETA; PIK4CB",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000354,,,,,,,,,,,,,,,,,,,200336,,,,,,,,,PIK4CB kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100121,"[""Gastric inhibitory polypeptide receptor""]",,"A gastric inhibitory polypeptide receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48546] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300047,,,,,,,,"A gastric inhibitory polypeptide receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48546] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100121,,,,https://pharos.nih.gov/idg/targets/P48546,,,,,,,,,,,,,GIPR,,,P48546,,,,,,,,Gastric inhibitory polypeptide receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000110,"[""amniotic cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000110,,,,,,,BrendaTissueOBO,,BTO:0000110,,,,,,,,,,,,,,,,,,,amniotic cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100575,"[""N-acetylgalactosamine kinase""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100575,,,,,,,,,,,,,,,,,GALK2,,,Q01415,,,,,,,,N-acetylgalactosamine kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100092,"[""Casein kinase II subunit alpha'""]",,A casein kinase II subunit alpha' that is encoded in the genome of human. ,false,,,http://www.drugtargetontology.org/dto/DTO_03300142,,,,,,,,A casein kinase II subunit alpha' that is encoded in the genome of human. ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100092,,,,https://pharos.nih.gov/idg/targets/P19784,,,,,,,,,,,,,CSNK2A2,CK2A2,,P19784,,,,,,,,Casein kinase II subunit alpha',,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100296,"[""Sodium channel subunit beta-4""]",,"A sodium channel subunit beta-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IWT1] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300470,,,,,,,,"A sodium channel subunit beta-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IWT1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100296,,,,https://pharos.nih.gov/idg/targets/Q8IWT1,,,,,,,,,,,,,SCN4B,,,Q8IWT1,,,,,,,,Sodium channel subunit beta-4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00400001,"[""Target development level""]",,A key aim of the KMC is to classify the development/druggability level of targets. KMC currently categorizes targets into four development/druggability levels (TDLs) defined as the subclasses.|target development level,false,,,http://purl.obolibrary.org/obo/BFO_0000019,,,,,,,,A key aim of the KMC is to classify the development/druggability level of targets. KMC currently categorizes targets into four development/druggability levels (TDLs) defined as the subclasses.|target development level,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00400001,,,,,,,,,,,,,,,,,,,,,,,,,,,,Target development level,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100819,"[""Vasoactive intestinal polypeptide receptor 2""]",,"A vasoactive intestinal polypeptide receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41587] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300003,,,,,,,,"A vasoactive intestinal polypeptide receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41587] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100819,,,,https://pharos.nih.gov/idg/targets/P41587,,,,,,,,,,,,,VIPR2,VIP2R,,P41587,,,,,,,,Vasoactive intestinal polypeptide receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100769,"[""Smoothened homolog""]",,"A smoothened that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99835] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300005,,,,,,,,"A smoothened that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99835] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100769,,,,https://pharos.nih.gov/idg/targets/Q99835,,,,,,,,,,,,,SMO,SMOH,,Q99835,,,,,,,,Smoothened homolog,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400248,"[""ABC1-C subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400120,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400248,,,,,,,,,,,,,,,,,,,,,,,,,,,,ABC1-C subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100467,"[""Opsin-5""]",,"An opsin-5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q6U736] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"An opsin-5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q6U736] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100467,,,,https://pharos.nih.gov/idg/targets/Q6U736,,,,,,,,,,,,,OPN5,GPR136|PGR12|TMEM13,,Q6U736,,,,,,,,Opsin-5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100060,"[""Cyclin-dependent kinase 14""]",,"cyclin-dependent kinase 14 (CDK14)  with  no mutation  in a nonphosphorylated state|A cyclin-dependent kinase 14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O94921] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300256,,,,,,,,"cyclin-dependent kinase 14 (CDK14)  with  no mutation  in a nonphosphorylated state|A cyclin-dependent kinase 14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O94921] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100060,,,,https://pharos.nih.gov/idg/targets/O94921,,,,,,,,,,,,,CDK14,KIAA0834|PFTK1,,O94921,,,,,,,,Cyclin-dependent kinase 14,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_7894,"[""mite infestation""]",,"A parasitic ectoparasitic infectious disease that involves infestation of mites belonging to the family Sarcoptidae, Trombiculidae and Demodicidae.",false,,,http://purl.obolibrary.org/obo/DOID_4110,,,,,,,,"A parasitic ectoparasitic infectious disease that involves infestation of mites belonging to the family Sarcoptidae, Trombiculidae and Demodicidae.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:7894,,,,SNOMEDCT_US_2016_03_01:266224002|ICD10CM:B88.0|SNOMEDCT_US_2016_03_01:78166003|SNOMEDCT_US_2016_03_01:240885009|SNOMEDCT_US_2016_03_01:187214007|ICD10CM:B88.9|UMLS_CUI:C0026229|SNOMEDCT_US_2016_03_01:154422001|ICD9CM:133.9|ICD9CM:133|MESH:D008924|SNOMEDCT_US_2016_03_01:187217000,,,disease_ontology,,DOID:7894,,,,,,,,,,,,,,,,,,,mite infestation,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000002,"[""AAK1 kinase domain""]",,AP2 associated kinase 1; AAK1; DKFZp686F03202; DKFZp686K16132; FLJ23712; FLJ25931; FLJ31060; FLJ42882; FLJ45252; KIAA1048; MGC138170; MGC164568; MGC164570,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,AP2 associated kinase 1; AAK1; DKFZp686F03202; DKFZp686K16132; FLJ23712; FLJ25931; FLJ31060; FLJ42882; FLJ45252; KIAA1048; MGC138170; MGC164568; MGC164570,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000002,,,,,,,,,,,,,,,,,,,200001,,,,,,,,,AAK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1360,"[""frontal sinus cancer""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0050619,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1360,,,,UMLS_CUI:C0153478|SNOMEDCT_US_2016_03_01:363427000|NCI:C3542|ICD10CM:C31.2|ICD9CM:160.4|SNOMEDCT_US_2016_03_01:93808006,malignant neoplasm of frontal sinus|malignant tumor of frontal sinus (disorder)|malignant tumor of the Frontal sinus,,disease_ontology,,DOID:1360,,,,,,,,,,,,,,,,,,,frontal sinus cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_7378,"[""pituitary hypoplasia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_53,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:7378,,,,UMLS_CUI:C0948740|NCI:C27343,,,disease_ontology,,DOID:7378,,,,,,,,,,,,,,,,,,,pituitary hypoplasia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2789,"[""parasitic protozoa infectious disease""]",,A parasitic infectious disease that is caused by parasitic protozoa which are microorganisms classified as unicellular eukaryotes.,false,,,http://purl.obolibrary.org/obo/DOID_1398,,,,,,,,A parasitic infectious disease that is caused by parasitic protozoa which are microorganisms classified as unicellular eukaryotes.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2789,,,DOID:3734|DOID:10553|DOID:3804|DOID:0060003|DOID:947,SNOMEDCT_US_2016_03_01:187247003|UMLS_CUI:C0033740|SNOMEDCT_US_2016_03_01:187502000|SNOMEDCT_US_2016_03_01:187517001|NCI:C34953|SNOMEDCT_US_2016_03_01:89933001|ICD10CM:B64|MESH:D011528|SNOMEDCT_US_2016_03_01:240627001|ICD10CM:B50-B64|SNOMEDCT_US_2016_03_01:95896000|SNOMEDCT_US_2016_03_01:367372008,mastigophora infectious disease|sarcomastigophora infectious disease,,disease_ontology,,DOID:2789,,,,,,,,,,,,,,,,,,,parasitic protozoa infectious disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400234,"[""TIE family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400234,,,,,,,,,,,,,,,,,,,,,,,,,,,,TIE family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400569,"[""KCa4.1/KCNT1 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400437,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400569,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCa4.1/KCNT1 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200311,"[""MELK gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400291,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200311,,,,,,,,,,,,,,,,9833,MELK,KIAA0175,,,,,,,,,,MELK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003246,"[""aortic endothelial cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0001519|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003246,,,,,,,BrendaTissueOBO,,BTO:0003246,,,,,,,,,,,,,,,,,,,aortic endothelial cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050335,"[""bradyopsia""]",,A retinal disease characterized by the slower than usual adaptation of the eyes to changing light conditions; can have material basis in mutations in the RGS9 or the R9AP genes.,false,,,http://purl.obolibrary.org/obo/DOID_5679,,,,,,,,A retinal disease characterized by the slower than usual adaptation of the eyes to changing light conditions; can have material basis in mutations in the RGS9 or the R9AP genes.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050335,,,,UMLS_CUI:C1842073|MESH:C564243|OMIM:608415|ORDO:75374|SNOMEDCT_US_2016_03_01:711163009,prolonged electroretinal response suppression,,disease_ontology,,DOID:0050335,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,bradyopsia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050332,"[""enlarged vestibular aqueduct""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_3426,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050332,,,,OMIM:600791,,,disease_ontology,,DOID:0050332,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,enlarged vestibular aqueduct,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050338,"[""primary bacterial infectious disease""]",,"A bacterial infectious disease that results_in infection by bacteria as a result of their presence or activity within the normal, healthy host, and their intrinsic virulence is, in part, a necessary consequence of their need to reproduce and spread.",false,,,http://purl.obolibrary.org/obo/DOID_104,,,,,,,,"A bacterial infectious disease that results_in infection by bacteria as a result of their presence or activity within the normal, healthy host, and their intrinsic virulence is, in part, a necessary consequence of their need to reproduce and spread.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050338,,,,,,,disease_ontology,,DOID:0050338,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,primary bacterial infectious disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050331,"[""LADD syndrome""]",,"An autosomal dominant disease that is characterized by abnormalities affecting the lacrimal and salivary glands and ducts, ears, teeth and fingers and toes.",false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,"An autosomal dominant disease that is characterized by abnormalities affecting the lacrimal and salivary glands and ducts, ears, teeth and fingers and toes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050331,,,,OMIM:149730,LEVY-HOLLISTER SYNDROME|lacrimoauriculodentodigital syndrome,,disease_ontology,,DOID:0050331,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,LADD syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050336,"[""hypophosphatemia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2485,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050336,,,,,,,disease_ontology,,DOID:0050336,,,,,,,,,,,,,,,,,,,hypophosphatemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050339,"[""commensal bacterial infectious disease""]",,"A bacterial infectious disease that results_in infection by bacteria which are part of the normal human flora when one or more of the defense mechanisms designed to restrict them from the usually sterile internal tissues are breached by accident, by intent (surgery), or by an underlying metabolic or an infectious disorder.",false,,,http://purl.obolibrary.org/obo/DOID_104,,,,,,,,"A bacterial infectious disease that results_in infection by bacteria which are part of the normal human flora when one or more of the defense mechanisms designed to restrict them from the usually sterile internal tissues are breached by accident, by intent (surgery), or by an underlying metabolic or an infectious disorder.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050339,,,,,,,disease_ontology,,DOID:0050339,,,,,,,,,,,,,,,,,,,commensal bacterial infectious disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200299,"[""OR10D4P gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200299,,,,,,,,,,,,,,,,390266,OR10D4P,OR10D4,,,,,,,,,,OR10D4P gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100726,"[""P2y purinoceptor 1""]",,"A P2Y purinoceptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47900] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300100,,,,,,,,"A P2Y purinoceptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47900] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100726,,,,https://pharos.nih.gov/idg/targets/P47900,,,,,,,,,,,,,P2RY1,,,P47900,,,,,,,,P2y purinoceptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400296,"[""MNK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400188,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400296,,,,,,,,,,,,,,,,,,,,,,,,,,,,MNK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3565,"[""meningioma""]",,"A central nervous system cancer that are manifested in the central nervous system and arise from the arachnoid ""cap"" cells of the arachnoid villi in the meninges.",false,,,http://purl.obolibrary.org/obo/DOID_3620,,,,,,,,"A central nervous system cancer that are manifested in the central nervous system and arise from the arachnoid ""cap"" cells of the arachnoid villi in the meninges.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3565,,,DOID:1137|DOID:4750|DOID:3567|DOID:3554,SNOMEDCT_US_2016_03_01:189940004|SNOMEDCT_US_2016_03_01:154621002|UMLS_CUI:C1334698|NCI:C3229|SNOMEDCT_US_2016_03_01:126965008|NCI:C7048|MESH:D008577|UMLS_CUI:C0025284|SNOMEDCT_US_2016_03_01:134307003|UMLS_CUI:C0349604|SNOMEDCT_US_2016_03_01:269643009|NCI:C6971|SNOMEDCT_US_2016_03_01:127579001|MESH:D008579|ICD10CM:D32.9|SNOMEDCT_US_2016_03_01:189945009|SNOMEDCT_US_2016_03_01:302820008|UMLS_CUI:C0025286|SNOMEDCT_US_2016_03_01:393566004|UMLS_CUI:C1336537|SNOMEDCT_US_2016_03_01:189941000|NCI:C4656|NCI:C3230,meningeal neoplasm|supratentorial meningioma|neoplasm of the meninges|primary Meningeal tumor|intracranial meningioma|meningothelial cell tumor,,disease_ontology,,DOID:3565,http://purl.obolibrary.org/obo/doid#DO_cancer_slim|http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,meningioma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100270,"[""Substance-P receptor""]",,"A substance-P receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25103] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300066,,,,,,,,"A substance-P receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25103] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100270,,,,https://pharos.nih.gov/idg/targets/P25103,,,,,,,,,,,,,TACR1,NK1R|TAC1R,,P25103,,,,,,,,Substance-P receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000308,"[""NDR2 kinase domain""]",,Serine/threonine kinase 38 like; KIAA0965; NDR2; STK38L,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine kinase 38 like; KIAA0965; NDR2; STK38L,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000308,,,,,,,,,,,,,,,,,,,200285,,,,,,,,,NDR2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003694,"[""CNS cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003694,,,,,,,BrendaTissueOBO,,BTO:0003694,,,,,,,,,,,,,,,,,,,CNS cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9884,"[""muscular dystrophy""]",,A myopathy is characterized by progressive skeletal muscle weakness degeneration.,false,,,http://purl.obolibrary.org/obo/DOID_423,,,,,,,,A myopathy is characterized by progressive skeletal muscle weakness degeneration.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9884,,,,OMIM:158800|SNOMEDCT_US_2016_03_01:193225000|ICD10CM:G71.0|SNOMEDCT_US_2016_03_01:73297009|MESH:D009136|OMIM:600416|SNOMEDCT_US_2016_03_01:155095006|NCI:C84910|SNOMEDCT_US_2016_03_01:193257004|OMIM:309930|UMLS_CUI:C0026850|OMIM:310095|OMIM:159050|SNOMEDCT_US_2016_03_01:267712004|OMIM:309950|SNOMEDCT_US_2016_03_01:44292004|ICD9CM:359.1|OMIM:310000|SNOMEDCT_US_2016_03_01:193236007,,,disease_ontology,,DOID:9884,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,muscular dystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_73688,"[""Ac-Asp-Glu""]","NAAG|InChI=1S/C11H16N2O8/c1-5(14)12-7(4-9(17)18)10(19)13-6(11(20)21)2-3-8(15)16/h6-7H,2-4H2,1H3,(H,12,14)(H,13,19)(H,15,16)(H,17,18)(H,20,21)/t6-,7-/m0/s1|CC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O|OPVPGKGADVGKTG-BQBZGAKWSA-N|C11H16N2O8|304.25330|N-Acetyl-1-aspartylglutamic acid|N-acetyl-L-Asp-L-Glu|N-Ac-D-E|isospaglumic acid|304.091|0",A dipeptide composed of N-acetyl-L-aspartic acid and L-glutamic acid joined by a peptide linkage.,false,,,http://purl.obolibrary.org/obo/CHEBI_33709,,,,,,,Wikipedia:N-Acetylaspartylglutamic_acid|KEGG:C12270|CAS:3106-85-2,A dipeptide composed of N-acetyl-L-aspartic acid and L-glutamic acid joined by a peptide linkage.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,N-acetyl-L-alpha-aspartyl-L-glutamic acid,,chebi_ontology,"NAAG|InChI=1S/C11H16N2O8/c1-5(14)12-7(4-9(17)18)10(19)13-6(11(20)21)2-3-8(15)16/h6-7H,2-4H2,1H3,(H,12,14)(H,13,19)(H,15,16)(H,17,18)(H,20,21)/t6-,7-/m0/s1|CC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O|OPVPGKGADVGKTG-BQBZGAKWSA-N|C11H16N2O8|304.25330|N-Acetyl-1-aspartylglutamic acid|N-acetyl-L-Asp-L-Glu|N-Ac-D-E|isospaglumic acid|304.091|0",,,CHEBI:73688,,,,,,,,,,,,,,,,,,,,,,,CHEBI:73688,,,,,Ac-Asp-Glu,,CHEBI:73688,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000338,"[""THR315 in ABL1(T315I)-phosphorylated""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000338,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR315 in ABL1(T315I)-phosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4007,"[""bladder carcinoma""]",,A urinary bladder cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.,false,,,http://purl.obolibrary.org/obo/DOID_11054|http://purl.obolibrary.org/obo/DOID_305,,,,,,,,A urinary bladder cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4007,,,,NCI:C4912|SNOMEDCT_US_2016_03_01:154540000|EFO:0000292|SNOMEDCT_US_2016_03_01:269607003|SNOMEDCT_US_2016_03_01:255108000|UMLS_CUI:C0699885,carcinoma of urinary bladder|carcinoma OF BLADDER|carcinoma of bladder (disorder)|carcinoma bladder,,disease_ontology,carcinoma of bladder,DOID:4007,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,bladder carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004078,"[""non-small cell lung adenocarcinoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002553,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004078,,,,,,,BrendaTissueOBO,,BTO:0004078,,,,,,,,,,,,,,,,,,,non-small cell lung adenocarcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100049,"[""Voltage-dependent L-type calcium channel subunit beta-2""]",,"A voltage-dependent L-type calcium channel subunit beta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q08289] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300334,,,,,,,,"A voltage-dependent L-type calcium channel subunit beta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q08289] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100049,,,,https://pharos.nih.gov/idg/targets/Q08289,,,,,,,,,,,,,CACNB2,CACNLB2|MYSB,,Q08289,,,,,,,,Voltage-dependent L-type calcium channel subunit beta-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200641,"[""OR5M11 gene""]",,"An olfactory receptor 5M11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RB7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5M11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RB7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200641,,,,,,,,,,,,,,,,219487,OR5M11,,,,,,,,,,,OR5M11 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200510,"[""OR2A4 gene""]",,"An olfactory receptor 2A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95047] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95047] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200510,,,,,,,,,,,,,,,,79541,OR2A4,OR2A10,,,,,,,,,,OR2A4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050161,"[""lower respiratory tract disease""]",,A respiratory system disease which involves the lower respiratory tract.,false,,,http://purl.obolibrary.org/obo/DOID_1579,,,,,,,,A respiratory system disease which involves the lower respiratory tract.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050161,,,,SNOMEDCT_US_2016_03_01:195823002|ICD9CM:478.19|UMLS_CUI:C0029581|SNOMEDCT_US_2016_03_01:266346007|ICD9CM:478.1,,,disease_ontology,,DOID:0050161,,,,,,,,,,,,,,,,,,,lower respiratory tract disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050168,"[""autoimmune polyendocrine syndrome type 2""]",,An autoimmune polyendocrine syndrome that is characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs. It is more heterogeneous and has not been linked to one gene.,false,,,http://purl.obolibrary.org/obo/DOID_14040,,,,,,,,An autoimmune polyendocrine syndrome that is characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs. It is more heterogeneous and has not been linked to one gene.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050168,,,,,Schmidt syndrome,,disease_ontology,,DOID:0050168,,,,,,,,,,,,,,,,,,,autoimmune polyendocrine syndrome type 2,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050167,"[""autoimmune polyendocrine syndrome type 1""]",,"An autoimmune polyendocrine syndrome that is inherited in an autosomal recessive fashion, which is characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs.",false,,,http://purl.obolibrary.org/obo/DOID_14040,,,,,,,,"An autoimmune polyendocrine syndrome that is inherited in an autosomal recessive fashion, which is characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050167,,,,OMIM:240300,Autoimmune Polyglandular Syndrome I|autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy|Whitaker syndrom,,disease_ontology,,DOID:0050167,,,,,,,,,,,,,,,,,,,autoimmune polyendocrine syndrome type 1,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000463,"[""filament""]",,"Part of the stamen in a flower that supports the anther. A chainlike series of cells, as in many algae.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Part of the stamen in a flower that supports the anther. A chainlike series of cells, as in many algae.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000463,,,,,,,BrendaTissueOBO,,BTO:0000463,,,,,,,,,,,,,,,,,,,filament,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200087,"[""CNGA3 gene""]",,"This gene encodes a member of the cyclic nucleotide-gated cation channel protein family which is required for normal vision and olfactory signal transduction. Mutations in this gene are associated with achromatopsia (rod monochromacy) and color blindness. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400404,,,,,,,,"This gene encodes a member of the cyclic nucleotide-gated cation channel protein family which is required for normal vision and olfactory signal transduction. Mutations in this gene are associated with achromatopsia (rod monochromacy) and color blindness. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200087,,,,,,,,,,,,,,,,1261,CNGA3,CNCG3,,,,,,,,,,CNGA3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400549,"[""Kv6.1/KCNG1 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400447,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400549,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv6.1/KCNG1 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200375,"[""NUAK2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400301,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200375,,,,,,,,,,,,,,,,81788,NUAK2,OMPHK2|SNARK,,,,,,,,,,NUAK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8337,"[""appendicitis""]",,"A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has_symptom pain, in the upper abdomen initially and later in the lower abdomen, has_symptom nausea, has_symptom vomiting and has_symptom fever.",false,,,http://purl.obolibrary.org/obo/DOID_1518,,,,,,,,"A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has_symptom pain, in the upper abdomen initially and later in the lower abdomen, has_symptom nausea, has_symptom vomiting and has_symptom fever.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8337,,,DOID:10276|DOID:10947|DOID:10275,SNOMEDCT_US_2016_03_01:155729003|SNOMEDCT_US_2016_03_01:155728006|NCI:C35145|SNOMEDCT_US_2016_03_01:155736002|ICD9CM:540-543.99|UMLS_CUI:C0003615|SNOMEDCT_US_2016_03_01:155733005|MESH:D001064|ICD9CM:541|ICD10CM:K37|SNOMEDCT_US_2016_03_01:74400008|SNOMEDCT_US_2016_03_01:307530000|SNOMEDCT_US_2016_03_01:196785005,acute appendicitis with generalized peritonitis (disorder)|acute appendicitis with peritoneal abscess|acute appendicitis|acute appendicitis with peritoneal abscess (disorder)|acute appendicitis with generalized peritonitis,,disease_ontology,,DOID:8337,,,,,,,,,,,,,,,,,,,appendicitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200821,"[""VN1R2 gene""]",,"A vomeronasal type-1 receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFZ6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400016,,,,,,,,"A vomeronasal type-1 receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFZ6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200821,,,,,,,,,,,,,,,,317701,VN1R2,V1RL2,,,,,,,,,,VN1R2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000123,"[""bladder""]",,A membranous sac in animals that serves as the receptacle of a liquid or contains gas.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001491,,,,,,,,A membranous sac in animals that serves as the receptacle of a liquid or contains gas.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000123,,,,,,,BrendaTissueOBO,,BTO:0000123,,,,,,,,,,,,,,,,,,,bladder,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100328,"[""Olfactory receptor 11A1""]",,"An olfactory receptor 11A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZK7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 11A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZK7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100328,,,,https://pharos.nih.gov/idg/targets/Q9GZK7,,,,,,,,,,,,,OR11A1,OR11A2,,Q9GZK7,,,,,,,,Olfactory receptor 11A1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001690,"[""B-cell lymphoma cell""]",,A cell of a group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000785,,,,,,,,A cell of a group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001690,,,,,,,BrendaTissueOBO,B-lymphoma cell,BTO:0001690,,,,,,,,,,,,,,,,,,,B-cell lymphoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100316,"[""Putative olfactory receptor 10J6""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100316,,,,https://pharos.nih.gov/idg/targets/Q8NGY7,,,,,,,,,,,,,OR10J6P,OR10J6,,Q8NGY7,,,,,,,,Putative olfactory receptor 10J6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217540,"[""RORA gene""]",,"The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_00217464,,,,,,,,"The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217540,,,,,,,,,,,,,,,,6095,RORA,NR1F1|RZRA,,,,,,,,,,RORA gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000766,"[""blood vessel endothelium""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000766,,,,,,,BrendaTissueOBO,,BTO:0000766,,,,,,,,,,,,,,,,,,,blood vessel endothelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000458,"[""WEE1 kinase domain""]",,Wee1-like protein kinase; DKFZp686I18166; FLJ16446; WEE1; WEE1A; WEE1hu,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Wee1-like protein kinase; DKFZp686I18166; FLJ16446; WEE1; WEE1A; WEE1hu,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000458,,,,,,,,,,,,,,,,,,,200460,,,,,,,,,WEE1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002439,"[""genital mucosa""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000886,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002439,,,,,,,BrendaTissueOBO,,BTO:0002439,,,,,,,,,,,,,,,,,,,genital mucosa,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001441,"[""marrow cell""]",,"Any of the immature blood cells that develop in the bone marrow, such as those involved in hematopoiesis.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000574,,,,,,,,"Any of the immature blood cells that develop in the bone marrow, such as those involved in hematopoiesis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001441,,,,,,,BrendaTissueOBO,myeloid cell,BTO:0001441,,,,,,,,,,,,,,,,,,,marrow cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200064,"[""CFTR gene""]",,"This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400392,,,,,,,,"This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200064,,,,,,,,,,,,,,,,1080,CFTR,ABCC7,,,,,,,,,,CFTR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000378,"[""RET(V804L) kinase domain""]",,Proto-oncogene tyrosine-protein kinase receptor Ret; CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET; RET51; RET-ELE1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Proto-oncogene tyrosine-protein kinase receptor Ret; CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET; RET51; RET-ELE1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000378,,,,,,,,,,,,,,,,,,,200372,,,,,,,,,RET(V804L) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003773,"[""oropharyngeal squamous cell carcinoma cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001289,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003773,,,,,,,BrendaTissueOBO,,BTO:0003773,,,,,,,,,,,,,,,,,,,oropharyngeal squamous cell carcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001111,"[""preputial gland""]",,Any of the small glands at the base of the glans penis that secrete smegma.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000080,,,,,,,,Any of the small glands at the base of the glans penis that secrete smegma.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001111,,,,,,,BrendaTissueOBO,gland of Tyson,BTO:0001111,,,,,,,,,,,,,,,,,,,preputial gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2355,"[""anemia""]",,A hematopoietic system disease that is characterized by a decrease in the normal number of red blood cells.,false,,,http://purl.obolibrary.org/obo/DOID_74,,,,,,,,A hematopoietic system disease that is characterized by a decrease in the normal number of red blood cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2355,,,,ICD9CM:285.9|EFO:0004272|MESH:D000740|SNOMEDCT_US_2016_03_01:64593003|ICD10CM:D64.9|UMLS_CUI:C0002871|SNOMEDCT_US_2016_03_01:271737000|NCI:C2869|SNOMEDCT_US_2016_03_01:154812000|SNOMEDCT_US_2016_03_01:267531008|SNOMEDCT_US_2016_03_01:154786001|SNOMEDCT_US_2016_03_01:191277004,anaemia,,disease_ontology,,DOID:2355,,,,,,,,,,,,,,,,,PRISM.,,anemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1285,"[""rectal disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5295,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1285,,,,MESH:D012002|UMLS_CUI:C0034882|SNOMEDCT_US_2016_03_01:5964004,,,disease_ontology,,DOID:1285,,,,,,,,,,,,,,,,,,,rectal disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12859,"[""choreatic disease""]",,"A movement disease characterized by brief, semi-directed, irregular movements that not repetitive or rhythmic, but appear to flow from one muscle to the next.",false,,,http://purl.obolibrary.org/obo/DOID_480,,,,,,,,"A movement disease characterized by brief, semi-directed, irregular movements that not repetitive or rhythmic, but appear to flow from one muscle to the next.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12859,,,,OMIM:215450|ORDO:1429|OMIM:118700|ICD10CM:G25.5,hereditary chorea|chorea,,disease_ontology,,DOID:12859,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,choreatic disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12858,"[""Huntington's disease""]",,"A neurodegenerative disease that has_material_basis_in autosomal dominant inheritance and is characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia and has_material_basis_in expansion of CAG triplet repeats (glutamine) resulting in neuron degeneration affecting muscle coordination, cognitive abilities.",false,,,http://purl.obolibrary.org/obo/DOID_1289,,,,,,,,"A neurodegenerative disease that has_material_basis_in autosomal dominant inheritance and is characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia and has_material_basis_in expansion of CAG triplet repeats (glutamine) resulting in neuron degeneration affecting muscle coordination, cognitive abilities.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12858,,,,KEGG:05016|ICD9CM:333.4|NCI:C82342|SNOMEDCT_US_2016_03_01:155006000|OMIM:143100|ICD10CM:G10|SNOMEDCT_US_2016_03_01:58756001|MESH:D006816|UMLS_CUI:C0020179,HD|Huntington's chorea|Huntington disease,,disease_ontology,,DOID:12858,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,Huntington's disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400341,"[""Chloride channel family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400341,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chloride channel family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002123,"[""primitive endoderm""]",,The primitive endoderm is the lower layer of the blastocyst that gives rise to fetal membranes.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The primitive endoderm is the lower layer of the blastocyst that gives rise to fetal membranes.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002123,,,,,,,BrendaTissueOBO,,BTO:0002123,,,,,,,,,,,,,,,,,,,primitive endoderm,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491025,"[""Diacylglycerol kinase family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400323,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491025,,,,,,,,,,,,,,,,,,,,,,,,,,,,Diacylglycerol kinase family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200548,"[""OR2T4 gene""]",,"An olfactory receptor 2T4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH00] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2T4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH00] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200548,,,,,,,,,,,,,,,,127074,OR2T4,,,,,,,,,,,OR2T4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004326,"[""ADF cell""]",,Human continuous glioblastoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001530,,,,,,,,Human continuous glioblastoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004326,,,,,,,BrendaTissueOBO,,BTO:0004326,,,,,,,,,,,,,,,,,,,ADF cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000838,"[""meconium""]",,A dark greenish mass that accumulates in the bowel during fetal life and is discharged shortly after birth.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A dark greenish mass that accumulates in the bowel during fetal life and is discharged shortly after birth.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000838,,,,,,,BrendaTissueOBO,,BTO:0000838,,,,,,,,,,,,,,,,,,,meconium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300545,"[""Kv4.1/KCND1 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300444,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300545,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv4.1/KCND1 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100247,"[""Leucine-rich repeat-containing protein 52""]",,"A leucine-rich repeat-containing protein 52 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N7C0] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,"A leucine-rich repeat-containing protein 52 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N7C0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100247,,,,https://pharos.nih.gov/idg/targets/Q8N7C0,,,,,,,,,,,,,LRRC52,,,Q8N7C0,,,,,,,,Leucine-rich repeat-containing protein 52,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_447,"[""renal tubular transport disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_557,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:447,,,,UMLS_CUI:C0035091|MESH:D015499,inborn renal tubular transport disorder,,disease_ontology,,DOID:447,,,,,,,,,,,,,,,,,,,renal tubular transport disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_440,"[""neuromuscular disease""]",,A neuropathy that affect the nerves that control the voluntary muscles.,false,,,http://purl.obolibrary.org/obo/DOID_870,,,,,,,,A neuropathy that affect the nerves that control the voluntary muscles.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:440,,,,UMLS_CUI:C0027868|ICD10CM:G70.9|SNOMEDCT_US_2016_03_01:255522009|MESH:D009468|ICD9CM:358.9|SNOMEDCT_US_2016_03_01:193218007|ICD9CM:358|SNOMEDCT_US_2016_03_01:257277002|SNOMEDCT_US_2016_03_01:1664005,,,disease_ontology,,DOID:440,,,,,,,,,,,,,,,,,,,neuromuscular disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_446,"[""hyperaldosteronism""]",,An adrenal gland hyperfunction disease that results in the overproduction of aldosterone by the adrenal glands.,false,,,http://purl.obolibrary.org/obo/DOID_3947,,,,,,,,An adrenal gland hyperfunction disease that results in the overproduction of aldosterone by the adrenal glands.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:446,,,,SNOMEDCT_US_2016_03_01:267484005|OMIM:605635|SNOMEDCT_US_2016_03_01:154709005|OMIM:613677|UMLS_CUI:C0020428|ICD10CM:E26|ICD9CM:255.10|SNOMEDCT_US_2016_03_01:88213004|NCI:C113213|SNOMEDCT_US_2016_03_01:190506003|ICD10CM:E26.9|ICD9CM:255.1|SNOMEDCT_US_2016_03_01:190509005|ORDO:235936|MESH:D006929,,,disease_ontology,,DOID:446,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,hyperaldosteronism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_445,"[""Bartter disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_447,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:445,,,,OMIM:PS601678|SNOMEDCT_US_2016_03_01:190506003|UMLS_CUI:C0004775|ICD9CM:255.13|NCI:C34412|SNOMEDCT_US_2016_03_01:707742001|MESH:D001477|SNOMEDCT_US_2016_03_01:71275003|ICD10CM:E26.81,Aldosteronism with hyperplasia of the adrenal cortex|Bartter's syndrome,,disease_ontology,,DOID:445,,,,,,,,,,,,,,,,,,,Bartter disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200338,"[""OR12D3 gene""]",,"An olfactory receptor 12D3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UGF7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 12D3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UGF7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200338,,,,,,,,,,,,,,,,81797,OR12D3,,,,,,,,,,,OR12D3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400538,"[""Kv1.7/KCNA7 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400436,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400538,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv1.7/KCNA7 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9977,"[""hallucinogen dependence""]",,A drug dependence that involves the continued use of hallucinogenic drugs despite problems related to use of the substance.,false,,,http://purl.obolibrary.org/obo/DOID_9974,,,,,,,,A drug dependence that involves the continued use of hallucinogenic drugs despite problems related to use of the substance.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9977,,,,SNOMEDCT_US_2016_03_01:191852008|SNOMEDCT_US_2016_03_01:191847003|ICD9CM:304.50|UMLS_CUI:C0018528|SNOMEDCT_US_2016_03_01:191848008|SNOMEDCT_US_2016_03_01:38247002|ICD9CM:304.5|SNOMEDCT_US_2016_03_01:268643000|ICD10CM:F16.2|NCI:C34657,,,disease_ontology,,DOID:9977,,,,,,,,,,,,,,,,,,,hallucinogen dependence,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100301,"[""Map kinase-activated protein kinase 5""]",,"MAP kinase-activated protein kinase 5 (MAPKAPK5)  with  no mutation  in a nonphosphorylated state|A MAP kinase-activated protein kinase 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IW41] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300289,,,,,,,,"MAP kinase-activated protein kinase 5 (MAPKAPK5)  with  no mutation  in a nonphosphorylated state|A MAP kinase-activated protein kinase 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IW41] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100301,,,,https://pharos.nih.gov/idg/targets/Q8IW41,,,,,,,,,,,,,MAPKAPK5,PRAK,,Q8IW41,,,,,,,,Map kinase-activated protein kinase 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200583,"[""GLYCTK gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200583,,,,,,,,,,,,,,,,,,,,,,,,,,,,GLYCTK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5263,"[""ovary leiomyosarcoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2146|http://purl.obolibrary.org/obo/DOID_1967,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5263,,,,UMLS_CUI:C1335163|NCI:C5234,leiomyosarcoma of Ovary,,disease_ontology,,DOID:5263,,,,,,,,,,,,,,,,,,,ovary leiomyosarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001557,"[""SF-767 cell""]",,Human glioblastoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001530,,,,,,,,Human glioblastoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001557,,,,,,,BrendaTissueOBO,SF767 cell,BTO:0001557,,,,,,,,,,,,,,,,,,,SF-767 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391036,"[""RIO3 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300217,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391036,,,,,,,,,,,,,,,,,,,,,,,,,,,,RIO3 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001526,"[""renal medulla cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001526,,,,,,,BrendaTissueOBO,,BTO:0001526,,,,,,,,,,,,,,,,,,,renal medulla cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002951,"[""624 cell""]",,Human melanoma cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0000849|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human melanoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002951,,,,,,,BrendaTissueOBO,624 mel cell|624mel cell,BTO:0002951,,,,,,,,,,,,,,,,,,,624 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_649,"[""prion disease""]",,"A brain disease that is characterized by brain damage resulting from the abnormal folding, clumping and accumulation of cellular proteins in the brain induced by prion proteins.",false,,,http://purl.obolibrary.org/obo/DOID_936,,,,,,,,"A brain disease that is characterized by brain damage resulting from the abnormal folding, clumping and accumulation of cellular proteins in the brain induced by prion proteins.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:649,,,,NCI:C27585|SNOMEDCT_US_2016_03_01:20484008|SNOMEDCT_US_2016_03_01:193172009|ICD10CM:A81.9|UMLS_CUI:C0162534|MESH:D017096|KEGG:05020|SNOMEDCT_US_2016_03_01:230284004,Prion protein disease|Prion disease pathway|Spongiform Encephalopathy|transmissible spongiform encephalopathy|prion induced disorder,,disease_ontology,,DOID:649,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,prion disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_643,"[""progressive multifocal leukoencephalopathy""]",,"A viral infectious disease that involves reactivation of JC polyomavirus in immune-compromised individuals which causes the loss of white matter (which is made up of myelin, a substance the surrounds and protects nerve fibers) in multiple areas of the brain. The symptoms include hemiparesis, aphasia, dysarthria, hemianopia, cognitive impairment and coma.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that involves reactivation of JC polyomavirus in immune-compromised individuals which causes the loss of white matter (which is made up of myelin, a substance the surrounds and protects nerve fibers) in multiple areas of the brain. The symptoms include hemiparesis, aphasia, dysarthria, hemianopia, cognitive impairment and coma.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:643,,,,NCI:C26815|ICD10CM:A81.2|SNOMEDCT_US_2016_03_01:22255007|UMLS_CUI:C0023524|ICD9CM:046.3|MESH:D007968,,,disease_ontology,PML,DOID:643,,,,,,,,,,,,,,,,,,,progressive multifocal leukoencephalopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100276,"[""Mitogen-activated protein kinase kinase kinase 10""]",,"A mitogen-activated protein kinase kinase kinase 10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02779] |mitogen-activated protein kinase kinase kinase 10 (MLK2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300284,,,,,,,,"A mitogen-activated protein kinase kinase kinase 10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02779] |mitogen-activated protein kinase kinase kinase 10 (MLK2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100276,,,,https://pharos.nih.gov/idg/targets/Q02779,,,,,,,,,,,,,MAP3K10,MLK2|MST,,Q02779,,,,,,,,Mitogen-activated protein kinase kinase kinase 10,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200197,"[""JAK2 gene""]",,"This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400167,,,,,,,,"This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200197,,,,,,,,,,,,,,,,3717,JAK2,,,,,,,,,,,JAK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400149,"[""SGK496 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400149,,,,,,,,,,,,,,,,,,,,,,,,,,,,SGK496 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200230,"[""TK2 gene""]",,"This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria. [provided by RefSeq, Dec 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03491008,,,,,,,,"This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria. [provided by RefSeq, Dec 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200230,,,,,,,,,,,,,,,,7084,TK2,,,,,,,,,,,TK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9007,"[""sudden infant death syndrome""]",,A syndrome that is characterized by the sudden death of an infant that is not predicted by medical history and remains unexplained after a thorough forensic autopsy and detailed death scene investigation.,false,,,http://purl.obolibrary.org/obo/DOID_225,,,,,,,,A syndrome that is characterized by the sudden death of an infant that is not predicted by medical history and remains unexplained after a thorough forensic autopsy and detailed death scene investigation.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9007,,,,SNOMEDCT_US_2016_03_01:207536007|OMIM:272120|MESH:D013398|NCI:C85173|ICD9CM:798.0|UMLS_CUI:C0038644|SNOMEDCT_US_2016_03_01:207538008|SNOMEDCT_US_2016_03_01:51178009|SNOMEDCT_US_2016_03_01:207534005|SNOMEDCT_US_2016_03_01:207535006|SNOMEDCT_US_2016_03_01:158718001|SNOMEDCT_US_2016_03_01:207671002,Sudden infant death syndrome NOS (context-dependent category)|Sudden infant death syndrome (context-dependent category)|Crib death (context-dependent category)|Sudden death of nonspecific cause in infancy|Cot death|Cot death (context-dependent category)|SIDS|Sudden infant death syndrome (finding),,disease_ontology,,DOID:9007,,,,,,,,,,,,,,,,,,,sudden infant death syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000384,"[""THR699 in EPHA3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000384,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR699 in EPHA3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200241,"[""PRKCD gene""]",,"Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400277,,,,,,,,"Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200241,,,,,,,,,,,,,,,,5580,PRKCD,,,,,,,,,,,PRKCD gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200548,"[""TXK gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400133,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200548,,,,,,,,,,,,,,,,7294,TXK,PTK4|RLK,,,,,,,,,,TXK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100426,"[""Extracellular tyrosine-protein kinase PKDCC""]",,"A protein kinase-like protein SgK493 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q504Y2] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300209,,,,,,,,"A protein kinase-like protein SgK493 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q504Y2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100426,,,,https://pharos.nih.gov/idg/targets/Q504Y2,,,,,,,,,,,,,PKDCC,SGK493|VLK,,Q504Y2,,,,,,,,Extracellular tyrosine-protein kinase PKDCC,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200559,"[""OR2Y1 gene""]",,"An olfactory receptor 2Y1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGV0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2Y1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGV0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200559,,,,,,,,,,,,,,,,134083,OR2Y1,,,,,,,,,,,OR2Y1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200242,"[""KCNU1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400571,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200242,,,,,,,,,,,,,,,,157855,KCNU1,KCNMA3|KCNMC1|SLO3,,,,,,,,,,KCNU1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400346,"[""Phagocyte (gp91(phox)) nadph oxidase family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400346,,,,,,,,,,,,,,,,,,,,,,,,,,,,Phagocyte (gp91(phox)) nadph oxidase family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200074,"[""CX3CR1 gene""]",,"A CX3C chemokine receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49238] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400096,,,,,,,,"A CX3C chemokine receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49238] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200074,,,,,,,,,,,,,,,,1524,CX3CR1,CMKBRL1|GPR13,,,,,,,,,,CX3CR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000189,"[""small cell lung cancer cell""]",,"A cell of a common, highly malignant form of bronchogenic carcinoma in the wall of a major bronchus, occurring mainly in middle-aged individuals with a history of tobacco smoking; it is radiosensitive and has small oval undifferentiated cells that are intensely hematoxyphilic. Metastasis to the hilum and to mediastinal lymph nodes is common.",false,,,http://purl.obolibrary.org/obo/BTO_0002061|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A cell of a common, highly malignant form of bronchogenic carcinoma in the wall of a major bronchus, occurring mainly in middle-aged individuals with a history of tobacco smoking; it is radiosensitive and has small oval undifferentiated cells that are intensely hematoxyphilic. Metastasis to the hilum and to mediastinal lymph nodes is common.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000189,,,,,,,BrendaTissueOBO,SCLC cell|small cell lung carcinoma cell|small cell carcinoma cell,BTO:0000189,,,,,,,,,,,,,,,,,,,small cell lung cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100100,"[""N-formyl peptide receptor 3""]",,"An N-formyl peptide receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25089] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300041,,,,,,,,"An N-formyl peptide receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25089] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100100,,,,https://pharos.nih.gov/idg/targets/P25089,,,,,,,,,,,,,FPR3,FPRH1|FPRL2,,P25089,,,,,,,,N-formyl peptide receptor 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004281,"[""C-81 cell""]",,HTLV-1-infected human T-cell line; established from patients with T-cell leukemia.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000741,,,,,,,,HTLV-1-infected human T-cell line; established from patients with T-cell leukemia.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004281,,,,,,,BrendaTissueOBO,C81 cell,BTO:0004281,,,,,,,,,,,,,,,,,,,C-81 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004757,"[""arterial endothelium""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000766,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004757,mgr,2010-09-30T10:33:17Z,,,,,BrendaTissueOBO,,BTO:0004757,,,,,,,,,,,,,,,,,,,arterial endothelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_18303,"[""phosphatidyl-L-serine""]",PS|phosphatidyl-L-serines|Phosphatidylserine|C8H12NO10PR2|N[C@@H](COP(O)(=O)OCC(COC([*])=O)OC([*])=O)C(O)=O|Ptd-L-Ser,"
A class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxy group of serine.
",false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,KEGG COMPOUND:C02737|CiteXplore:23543734|DrugBank:DB00144|CiteXplore:3196084|CiteXplore:8626656|CiteXplore:8204602|Patent:EP2322184|CiteXplore:9677350|Patent:HK1046237|Patent:US2011098249|CiteXplore:10540156|CiteXplore:3106116|HMDB:HMDB14291|Wikipedia:Phosphatidylserine|CiteXplore:19687511|CiteXplore:15533308|CiteXplore:4153523|MetaCyc:L-1-PHOSPHATIDYL-SERINE,"
A class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxy group of serine.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:26041|CHEBI:8137|CHEBI:14801,,,,chebi_ontology,PS|phosphatidyl-L-serines|Phosphatidylserine|C8H12NO10PR2|N[C@@H](COP(O)(=O)OCC(COC([*])=O)OC([*])=O)C(O)=O|Ptd-L-Ser,,,CHEBI:18303,,,,,,,,,,,,,,,,,,,,,,,CHEBI:18303,,,,,phosphatidyl-L-serine,,CHEBI:18303,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2384,"[""Wernicke encephalopathy""]",,"A brain disease that is characterised by the presence of neurological symptoms of ophthalmoplegia, ataxia, and confusion caused by biochemical lesions of the central nervous system after exhaustion of B-vitamin reserves, in particular thiamine (vitamin B1).",false,,,http://purl.obolibrary.org/obo/DOID_936,,,,,,,,"A brain disease that is characterised by the presence of neurological symptoms of ophthalmoplegia, ataxia, and confusion caused by biochemical lesions of the central nervous system after exhaustion of B-vitamin reserves, in particular thiamine (vitamin B1).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2384,,,,UMLS_CUI:C0043121|ICD10CM:E51.2|SNOMEDCT_US_2016_03_01:190627001|SNOMEDCT_US_2016_03_01:21007002|MESH:D014899|SNOMEDCT_US_2016_03_01:190626005,Wernicke's encephalopathy|Wernicke's disease,,disease_ontology,,DOID:2384,,,,,,,,,,,,,,,,,,,Wernicke encephalopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001085,"[""vascular system""]",,"The vessels of the body, especially the blood vessels.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The vessels of the body, especially the blood vessels.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001085,,,,,,,BrendaTissueOBO,Gefaesssystem,BTO:0001085,,,,,,,,,,,,,,,,,,,vascular system,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100510,"[""Olfactory receptor 2a4""]",,"An olfactory receptor 2A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95047] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95047] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100510,,,,https://pharos.nih.gov/idg/targets/O95047,,,,,,,,,,,,,OR2A4,OR2A10,,O95047,,,,,,,,Olfactory receptor 2a4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100300,"[""Sodium channel protein type 9 subunit alpha""]",,"A sodium channel protein type 9 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15858] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300474,,,,,,,,"A sodium channel protein type 9 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15858] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100300,,,,https://pharos.nih.gov/idg/targets/Q15858,,,,,,,,,,,,,SCN9A,NENA,,Q15858,,,,,,,,Sodium channel protein type 9 subunit alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000351,"[""PIK3CB kinase domain""]",,"Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; DKFZp779K1237; MGC133043; P110BETA; PI3K; PI3KBETA; PIK3C1; PIK3CB; PI3K-beta",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; DKFZp779K1237; MGC133043; P110BETA; PI3K; PI3KBETA; PIK3C1; PIK3CB; PI3K-beta",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000351,,,,,,,,,,,,,,,,,,,200333,,,,,,,,,PIK3CB kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200244,"[""KCNV2 gene""]",,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This member is identified as a 'silent subunit', and it does not form homomultimers, but forms heteromultimers with several other subfamily members. Through obligatory heteromerization, it exerts a function-altering effect on other potassium channel subunits. This protein is strongly expressed in pancreas and has a weaker expression in several other tissues. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400573,,,,,,,,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This member is identified as a 'silent subunit', and it does not form homomultimers, but forms heteromultimers with several other subfamily members. Through obligatory heteromerization, it exerts a function-altering effect on other potassium channel subunits. This protein is strongly expressed in pancreas and has a weaker expression in several other tissues. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200244,,,,,,,,,,,,,,,,169522,KCNV2,,,,,,,,,,,KCNV2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200310,"[""TMC2 gene""]",,"This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, expression in the inner ear suggests that it may be crucial for normal auditory function. Mutations in this gene may underlie hereditary disorders of balance and hearing. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400372,,,,,,,,"This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, expression in the inner ear suggests that it may be crucial for normal auditory function. Mutations in this gene may underlie hereditary disorders of balance and hearing. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200310,,,,,,,,,,,,,,,,117532,TMC2,C20orf145,,,,,,,,,,TMC2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001607,"[""swim bladder""]",,The air bladder of a fish.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002148,,,,,,,,The air bladder of a fish.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001607,,,,,,,BrendaTissueOBO,air bladder,BTO:0001607,,,,,,,,,,,,,,,,,,,swim bladder,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100466,"[""Melanopsin""]",,"A melanopsin that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UHM6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A melanopsin that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UHM6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100466,,,,https://pharos.nih.gov/idg/targets/Q9UHM6,,,,,,,,,,,,,OPN4,MOP,,Q9UHM6,,,,,,,,Melanopsin,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11111,"[""hydronephrosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5200,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11111,,,,SNOMEDCT_US_2016_03_01:197791000|ICD9CM:591|SNOMEDCT_US_2016_03_01:155866001|NCI:C26796|MESH:D006869|SNOMEDCT_US_2016_03_01:43064006|UMLS_CUI:C0020295|ICD10CM:N13.30,,,disease_ontology,,DOID:11111,,,,,,,,,,,,,,,,,,,hydronephrosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11119,"[""Gilles de la Tourette syndrome""]",,A tic disorder that is characterized by multiple physical (motor) tics and at least one vocal (phonic) tic present for more than a year.,false,,,http://purl.obolibrary.org/obo/DOID_2769,,,,,,,,A tic disorder that is characterized by multiple physical (motor) tics and at least one vocal (phonic) tic present for more than a year.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11119,,,,EFO:0004895|SNOMEDCT_US_2016_03_01:39098006|SNOMEDCT_US_2016_03_01:268778009|OMIM:137580|SNOMEDCT_US_2016_03_01:192624004|MESH:D005879|SNOMEDCT_US_2016_03_01:5158005|ICD10CM:F95.2|SNOMEDCT_US_2016_03_01:154936002|NCI:C35078|ICD9CM:307.23|UMLS_CUI:C0040517,motor-verbal tic disorder|Guinon's disease|Psychogenic tics|Tourette syndrome,,disease_ontology,,DOID:11119,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Gilles de la Tourette syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100334,"[""Olfactory receptor 11h7""]",,"An olfactory receptor 11H7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 11H7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100334,,,,https://pharos.nih.gov/idg/targets/Q8NGC8,,,,,,,,,,,,,OR11H7,OR11H7P,,Q8NGC8,,,,,,,,Olfactory receptor 11h7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4411,"[""hepatitis E""]",,"A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis E virus, which is transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom dark urine, has_symptom joint pain, and has_symptom jaundice.",false,,,http://purl.obolibrary.org/obo/DOID_37|http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis E virus, which is transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom dark urine, has_symptom joint pain, and has_symptom jaundice.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4411,,,DOID:12431,MESH:D016751|UMLS_CUI:C0085293|SNOMEDCT_US_2016_03_01:7111000119109,,,disease_ontology,,DOID:4411,http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,hepatitis E,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002868,"[""bladder transitional cell carcinoma cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0002869|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002868,,,,,,,BrendaTissueOBO,,BTO:0002868,,,,,,,,,,,,,,,,,,,bladder transitional cell carcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1270,"[""hereditary hemorrhagic telangiectasia""]",,An autosomal dominant disease characterized by the presence of multiple arteriovenous malformations that lack intervening capillaries and result in direct connections between arteries and veins.,false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,An autosomal dominant disease characterized by the presence of multiple arteriovenous malformations that lack intervening capillaries and result in direct connections between arteries and veins.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1270,,,,OMIM:615506|OMIM:187300|SNOMEDCT_US_2016_03_01:266324004|OMIM:601101|SNOMEDCT_US_2016_03_01:21877004|UMLS_CUI:C0039445|NCI:C35064|ICD9CM:448.0|ORDO:774|MESH:D013683|SNOMEDCT_US_2016_03_01:155449008|OMIM:600376|ICD10CM:I78.0,Rendu-Osler-Weber disease|Osler-Weber-Rendu disease|Osler hemorrhagic telangiectasia syndrome,,disease_ontology,,DOID:1270,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,hereditary hemorrhagic telangiectasia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12704,"[""ataxia telangiectasia""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050950,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12704,,,,OMIM:208900|MESH:D001260|UMLS_CUI:C0004135|SNOMEDCT_US_2016_03_01:68504005|NCI:C2887,Boder-Sedgwick syndrome|Louis Bar syndrome,,disease_ontology,,DOID:12704,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,ataxia telangiectasia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12700,"[""hyperprolactinemia""]",,An acquired metabolic disease that has_material_basis_in the presence of abnormally-high levels of prolactin in the blood.,false,,,http://purl.obolibrary.org/obo/DOID_0060158,,,,,,,,An acquired metabolic disease that has_material_basis_in the presence of abnormally-high levels of prolactin in the blood.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12700,,,DOID:12699,NCI:C113168|SNOMEDCT_US_2016_03_01:85039006|UMLS_CUI:C0020514|MESH:D006966|ICD10CM:E22.1|SNOMEDCT_US_2016_03_01:190468001|SNOMEDCT_US_2016_03_01:367422005|SNOMEDCT_US_2016_03_01:237662005|UMLS_CUI:C0008043|MESH:D002640|SNOMEDCT_US_2016_03_01:21170004,Chiari-Frommel syndrome|hyperprolactinaemia|Pregnancy-related A-G syndrome (disorder),,disease_ontology,,DOID:12700,,,,,,,,,,,,,,,,,,,hyperprolactinemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12705,"[""Friedreich ataxia""]",,Xref MGI.,false,,,http://purl.obolibrary.org/obo/DOID_0050950,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12705,,,DOID:0050555,OMIM:601992|UMLS_CUI:C0016719|SNOMEDCT_US_2016_03_01:155011003|MESH:D005621|SNOMEDCT_US_2016_03_01:10394003|ICD9CM:334.0|NCI:C84718|OMIM:229300,Friedreich's ataxia|Friedreich's tabes|Friedreich ataxia 1,,disease_ontology,,DOID:12705,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,Xref MGI.,,Friedreich ataxia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3721,"[""plasmacytoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_6536,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3721,,,,SNOMEDCT_US_2016_03_01:188719003|SNOMEDCT_US_2016_03_01:190017008|SNOMEDCT_US_2016_03_01:415112005|NCI:C9349|SNOMEDCT_US_2016_03_01:188720009|UMLS_CUI:C0032131|SNOMEDCT_US_2016_03_01:189507001|ICD10CM:C90.3|SNOMEDCT_US_2016_03_01:274907000|SNOMEDCT_US_2016_03_01:190016004|SNOMEDCT_US_2016_03_01:302852008|SNOMEDCT_US_2016_03_01:190019006|SNOMEDCT_US_2016_03_01:308122007|SNOMEDCT_US_2016_03_01:154644004|SNOMEDCT_US_2016_03_01:269652000|NCI:C6932|SNOMEDCT_US_2016_03_01:10639003|SNOMEDCT_US_2016_03_01:109987008|MESH:D010954|ICD10CM:C90.30,"Myeloma, solitary|Myeloma - solitary|Solitary myeloma|Solitary plasmacytoma",,disease_ontology,,DOID:3721,,,,,,,,,,,,,,,,,,,plasmacytoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300119,"[""STKR family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300107,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300119,,,,,,,,,,,,,,,,,,,,,,,,,,,,STKR family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100003,"[""5-hydroxytryptamine receptor 1D""]",,"A 5-hydroxytryptamine receptor 1D that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28221] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302001,,,,,,,,"A 5-hydroxytryptamine receptor 1D that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28221] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100003,,,,https://pharos.nih.gov/idg/targets/P28221,,,,,,,,,,,,,HTR1D,HTR1DA|HTRL,,P28221,,,,,,,,5-hydroxytryptamine receptor 1D,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001123,"[""peripheral ganglion""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000497,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001123,,,,,,,BrendaTissueOBO,,BTO:0001123,,,,,,,,,,,,,,,,,,,peripheral ganglion,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100120,"[""Gamma-aminobutyric acid receptor subunit gamma-3""]",,"A gamma-aminobutyric acid receptor subunit gamma-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99928] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300519,,,,,,,,"A gamma-aminobutyric acid receptor subunit gamma-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99928] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100120,,,,https://pharos.nih.gov/idg/targets/Q99928,,,,,,,,,,,,,GABRG3,,,Q99928,,,,,,,,Gamma-aminobutyric acid receptor subunit gamma-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400479,"[""SCNN1D subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400330,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400479,,,,,,,,,,,,,,,,,,,,,,,,,,,,SCNN1D subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000457,"[""VRK2 kinase domain""]",,Serine/threonine-protein kinase VRK2; vaccinia related kinase 2; VRK2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase VRK2; vaccinia related kinase 2; VRK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000457,,,,,,,,,,,,,,,,,,,200459,,,,,,,,,VRK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200573,"[""ETNK1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200573,,,,,,,,,,,,,,,,,,,,,,,,,,,,ETNK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400520,"[""GABRP sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400520,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRP sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200609,"[""OR4X1 gene""]",,"An olfactory receptor 4X1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH49] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4X1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH49] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200609,,,,,,,,,,,,,,,,390113,OR4X1,,,,,,,,,,,OR4X1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001676,"[""PC-12D cell""]",,A cell line which originated from a pheochromocytoma in rat adrenal medulla.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A cell line which originated from a pheochromocytoma in rat adrenal medulla.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001676,,,,,,,BrendaTissueOBO,PC12D cell,BTO:0001676,,,,,,,,,,,,,,,,,,,PC-12D cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200165,"[""GPR174 gene""]",,"A G-protein coupled receptor 174 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BXC1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 174 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BXC1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200165,,,,,,,,,,,,,,,,84636,GPR174,,,,,,,,,,,GPR174 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100018,"[""I1043 in PIK3CA(M1043I)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100018,,,,,,,,,,,,,,,,,,,,,,,,,,,,I1043 in PIK3CA(M1043I),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100117,"[""Gamma-aminobutyric acid receptor subunit epsilon""]",,"A gamma-aminobutyric acid receptor subunit epsilon that is encoded in the genome of human. [PRO:DNx, UniProtKB:P78334] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300516,,,,,,,,"A gamma-aminobutyric acid receptor subunit epsilon that is encoded in the genome of human. [PRO:DNx, UniProtKB:P78334] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100117,,,,https://pharos.nih.gov/idg/targets/P78334,,,,,,,,,,,,,GABRE,,,P78334,,,,,,,,Gamma-aminobutyric acid receptor subunit epsilon,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300149,"[""SGK496 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300149,,,,,,,,,,,,,,,,,,,,,,,,,,,,SGK496 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200600,"[""OR4M2 gene""]",,"An olfactory receptor 4M2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4M2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200600,,,,,,,,,,,,,,,,390538,OR4M2,,,,,,,,,,,OR4M2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100192,"[""Potassium voltage-gated channel subfamily c member 4""]",,"A voltage-gated potassium channel KCNC4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q03721] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300544,,,,,,,,"A voltage-gated potassium channel KCNC4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q03721] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100192,,,,https://pharos.nih.gov/idg/targets/Q03721,,,,,,,,,,,,,KCNC4,,,Q03721,,,,,,,,Potassium voltage-gated channel subfamily c member 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12294,"[""atypical depressive disorder""]",,"A mood disorder that is characterized by mood reactivity (paradoxical anhedonia) and positivity, significant weight gain or increased appetite (""comfort eating""), excessive sleep or somnolence (hypersomnia), a sensation of heaviness in limbs known as leaden paralysis, and significant social impairment as a consequence of hypersensitivity to perceived interpersonal rejection.",false,,,http://purl.obolibrary.org/obo/DOID_3324,,,,,,,,"A mood disorder that is characterized by mood reactivity (paradoxical anhedonia) and positivity, significant weight gain or increased appetite (""comfort eating""), excessive sleep or somnolence (hypersomnia), a sensation of heaviness in limbs known as leaden paralysis, and significant social impairment as a consequence of hypersensitivity to perceived interpersonal rejection.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12294,,,,SNOMEDCT_US_2016_03_01:191659001|UMLS_CUI:C0154437|SNOMEDCT_US_2016_03_01:277538003|SNOMEDCT_US_2016_03_01:192371004|ICD9CM:296.82|ICD10CM:F32.8,Atypical depression,,disease_ontology,,DOID:12294,,,,,,,,,,,,,,,,,,,atypical depressive disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200351,"[""OR14A2 gene""]",,"An olfactory receptor 14A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R54] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 14A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R54] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200351,,,,,,,,,,,,,,,,388761,OR14A2,OR5AX1|OR5AX1P,,,,,,,,,,OR14A2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002052,"[""osteogenic cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002052,,,,,,,BrendaTissueOBO,,BTO:0002052,,,,,,,,,,,,,,,,,,,osteogenic cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300152,"[""EGFR family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300152,,,,,,,,,,,,,,,,,,,,,,,,,,,,EGFR family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400024,"[""Apelin receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400024,,,,,,,,,,,,,,,,,,,,,,,,,,,,Apelin receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100720,"[""Olfactory receptor 9Q2""]",,"An olfactory receptor 9Q2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 9Q2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100720,,,,https://pharos.nih.gov/idg/targets/Q8NGE9,,,,,,,,,,,,,OR9Q2,OR9Q2P,,Q8NGE9,,,,,,,,Olfactory receptor 9Q2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000133,"[""Prokineticin-2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000133,,,,,,,,,,,,,,,,,,,,,,,,,,,,Prokineticin-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002808,"[""B16-BL6 cell""]",,Mouse melanoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Mouse melanoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002808,,,,,,,BrendaTissueOBO,B16/BL6 cell,BTO:0002808,,,,,,,,,,,,,,,,,,,B16-BL6 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100337,"[""Olfactory receptor 12D2""]",,"An olfactory receptor 12D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58182] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 12D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58182] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100337,,,,https://pharos.nih.gov/idg/targets/P58182,,,,,,,,,,,,,OR12D2,,,P58182,,,,,,,,Olfactory receptor 12D2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300410,"[""GRIA1 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300410,,,,,,,,,,,,,,,,,,,,,,,,,,,,GRIA1 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2590,"[""familial nephrotic syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1184,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2590,,,,MESH:C535761|ICD10CM:N04|SNOMEDCT_US_2016_03_01:48796009|UMLS_CUI:C3501848|SNOMEDCT_US_2016_03_01:197602005|NCI:C35337,Congenital Nephrotic syndrome|Congenital nephrotic syndrome,,disease_ontology,,DOID:2590,,,,,,,,,,,,,,,,,,,familial nephrotic syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000304,"[""PANC-1 cell""]",,"Human, Caucasian, pancreas, carcinoma cell line. Established from a pancreatic carcinoma of ductal origin from a 56-year-old Caucasian male. Cells possess the type B phenotype for G6PD.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000794,,,,,,,,"Human, Caucasian, pancreas, carcinoma cell line. Established from a pancreatic carcinoma of ductal origin from a 56-year-old Caucasian male. Cells possess the type B phenotype for G6PD.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000304,,,,,,,BrendaTissueOBO,,BTO:0000304,,,,,,,,,,,,,,,,,,,PANC-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100036,"[""Type-1 angiotensin II receptor""]",,"An angiotensin II receptor 1A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30556] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300023,,,,,,,,"An angiotensin II receptor 1A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30556] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100036,,,,https://pharos.nih.gov/idg/targets/P30556,,,,,,,,,,,,,AGTR1,AGTR1A|AGTR1B|AT2R1|AT2R1B,,P30556,,,,,,,,Type-1 angiotensin II receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02302008,"[""Adhesion class""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300001,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02302008,,,,,,,,,,,,,,,,,,,,,,,,,,,,Adhesion class,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000422,"[""VAL555 in FGFR3(G697C)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000422,,,,,,,,,,,,,,,,,,,,,,,,,,,,VAL555 in FGFR3(G697C),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002617,"[""thyroid nodule""]",,"Pathological nodule in the thyroid gland, often filled with colloid; some are indicative of adenoma or carcinoma.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Pathological nodule in the thyroid gland, often filled with colloid; some are indicative of adenoma or carcinoma.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002617,,,,,,,BrendaTissueOBO,,BTO:0002617,,,,,,,,,,,,,,,,,,,thyroid nodule,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1518,"[""cecal disease""]",,An intestinal disease located_in the cecum.,false,,,http://purl.obolibrary.org/obo/DOID_5295,,,,,,,,An intestinal disease located_in the cecum.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1518,,,,MESH:D002429|UMLS_CUI:C0007527|SNOMEDCT_US_2016_03_01:128525008,disorder of cecum (disorder),,disease_ontology,,DOID:1518,,,,,,,,,,,,,,,,,,,cecal disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2741,"[""bilirubin metabolic disorder""]",,An inherited metabolic disorder that involves elevated levels of bilirubin resulting from disruption of bilirubin metabolism.,false,,,http://purl.obolibrary.org/obo/DOID_655,,,,,,,,An inherited metabolic disorder that involves elevated levels of bilirubin resulting from disruption of bilirubin metabolism.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2741,,,DOID:2740,SNOMEDCT_US_2016_03_01:20505009|SNOMEDCT_US_2016_03_01:166612004|SNOMEDCT_US_2016_03_01:143932000|UMLS_CUI:C0020433|SNOMEDCT_US_2016_03_01:235904007|SNOMEDCT_US_2016_03_01:154770008|MESH:D006933|SNOMEDCT_US_2016_03_01:267509000|UMLS_CUI:C0020435|NCI:C84761|SNOMEDCT_US_2016_03_01:14783006|MESH:D006932,hereditary hyperbilirubinemia|hyperbilirubinemia,,disease_ontology,hyperbilirubinaemia,DOID:2741,,,,,,,,,,,,,,,,,,,bilirubin metabolic disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000032,"[""Gastric inhibitory polypeptide""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000032,,,,,,,,,,,,,,,,,,,,,,,,,,,,Gastric inhibitory polypeptide,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100052,"[""Mitotic checkpoint serine/threonine-protein kinase bub1""]",,"A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of human. [PMID:10749118, PMID:11030144, PMID:11792804, PMID:12719470, PMID:15190214, PMID:15525512, PMID:15592459, PMID:16760428, PMID:17671183, PMID:17785528, PMID:20016069, PMID:20624902, PMID:20703093, PRO:KER] |mitotic checkpoint serine/threonine-protein kinase bub1 (BUB1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300134,,,,,,,,"A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of human. [PMID:10749118, PMID:11030144, PMID:11792804, PMID:12719470, PMID:15190214, PMID:15525512, PMID:15592459, PMID:16760428, PMID:17671183, PMID:17785528, PMID:20016069, PMID:20624902, PMID:20703093, PRO:KER] |mitotic checkpoint serine/threonine-protein kinase bub1 (BUB1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100052,,,,https://pharos.nih.gov/idg/targets/O43683,,,,,,,,,,,,,BUB1,BUB1L,,O43683,,,,,,,,Mitotic checkpoint serine/threonine-protein kinase bub1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004041,"[""abdominal adipose tissue""]",,"Adipose tissue located inside the peritoneal cavity, packed in between internal organs and torso. An excess of visceral fat is known as central obesity, or belly fat, the pot belly or beer belly effect, in which the abdomen protrudes excessively.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001487,,,,,,,,"Adipose tissue located inside the peritoneal cavity, packed in between internal organs and torso. An excess of visceral fat is known as central obesity, or belly fat, the pot belly or beer belly effect, in which the abdomen protrudes excessively.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004041,,,,,,,BrendaTissueOBO,visceral fat|intra-abdominal fat|abdominal fat|visceral adipose tissue|organ fat,BTO:0004041,,,,,,,,,,,,,,,,,,,abdominal adipose tissue,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300360,"[""Transient receptor potential calcium channel (TRP-CC) family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300360,,,,,,,,,,,,,,,,,,,,,,,,,,,,Transient receptor potential calcium channel (TRP-CC) family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400168,"[""TRIO family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400168,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRIO family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200018,"[""ACKR2 gene""]",,"A chemokine-binding protein 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00590] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400031,,,,,,,,"A chemokine-binding protein 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00590] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200018,,,,,,,,,,,,,,,,1238,ACKR2,CCBP2|CCR10|CMKBR9|D6,,,,,,,,,,ACKR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000381,"[""embryonic blood""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0000089|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000381,,,,,,,BrendaTissueOBO,,BTO:0000381,,,,,,,,,,,,,,,,,,,embryonic blood,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200166,"[""ITPR2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400354,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200166,,,,,,,,,,,,,,,,3709,ITPR2,,,,,,,,,,,ITPR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000113,"[""MET129 in LKB1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000113,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET129 in LKB1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004760,"[""TF-1 cell""]",,Human bone marrow erythroleukemia cell line. The TF-1 cell line has been established in October 1987 from a heparinized bone marrow aspiration sample from a 35 year old Japanese male with severe pancytopenia.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000846|http://purl.obolibrary.org/obo/BTO_0000264,,,,,,,,Human bone marrow erythroleukemia cell line. The TF-1 cell line has been established in October 1987 from a heparinized bone marrow aspiration sample from a 35 year old Japanese male with severe pancytopenia.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004760,mgr,2010-09-30T10:40:21Z,,,,,BrendaTissueOBO,,BTO:0004760,,,,,,,,,,,,,,,,,,,TF-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200518,"[""OR2C1 gene""]",,"An olfactory receptor 2C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95371] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95371] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200518,,,,,,,,,,,,,,,,4993,OR2C1,OR2C2P,,,,,,,,,,OR2C1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200239,"[""PRKD2 gene""]",,"The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400176,,,,,,,,"The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200239,,,,,,,,,,,,,,,,25865,PRKD2,PKD2,,,,,,,,,,PRKD2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001625,"[""laryngeal cancer cell""]",,"Cancer or tumor cell of the larynx or any of its parts: the glottis, epiglottis, laryngeal cartilages, laryngeal muscles, and vocal cords.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Cancer or tumor cell of the larynx or any of its parts: the glottis, epiglottis, laryngeal cartilages, laryngeal muscles, and vocal cords.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001625,,,,,,,BrendaTissueOBO,,BTO:0001625,,,,,,,,,,,,,,,,,,,laryngeal cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400332,"[""Calcium channel auxiliary subunit 2 types 1-4 (cca-2) family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400332,,,,,,,,,,,,,,,,,,,,,,,,,,,,Calcium channel auxiliary subunit 2 types 1-4 (cca-2) family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217530,"[""THRA gene""]",,"The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_00217460,,,,,,,,"The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217530,,,,,,,,,,,,,,,,7067,THRA,EAR7|ERBA1|NR1A1,,,,,,,,,,THRA gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000473,"[""fetal membrane""]",,Any membrane that functions for the protection or nourishment of respiration or excretion of a developing fetus.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Any membrane that functions for the protection or nourishment of respiration or excretion of a developing fetus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000473,,,,,,,BrendaTissueOBO,,BTO:0000473,,,,,,,,,,,,,,,,,,,fetal membrane,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200268,"[""LIMK2 gene""]",,"There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400283,,,,,,,,"There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200268,,,,,,,,,,,,,,,,3985,LIMK2,,,,,,,,,,,LIMK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200420,"[""OR52E8 gene""]",,"An olfactory receptor 52E8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IFG1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 52E8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IFG1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200420,,,,,,,,,,,,,,,,390079,OR52E8,,,,,,,,,,,OR52E8 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400562,"[""Kv7.2/KCNQ2 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400449,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400562,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv7.2/KCNQ2 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005124,"[""platysma muscle""]",,The platysma is a superficial muscle that overlaps the sternocleidomastoid.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000021,,,,,,,,The platysma is a superficial muscle that overlaps the sternocleidomastoid.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005124,XPMUser,2011-05-06T10:32:35Z,,,,,BrendaTissueOBO,neck platysma muscle|platysma,BTO:0005124,,,,,,,,,,,,,,,,,,,platysma muscle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100018,"[""Acetylcholine receptor subunit beta""]",,"An acetylcholine receptor subunit beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11230] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300502,,,,,,,,"An acetylcholine receptor subunit beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11230] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100018,,,,https://pharos.nih.gov/idg/targets/P11230,,,,,,,,,,,,,CHRNB1,ACHRB|CHRNB,,P11230,,,,,,,,Acetylcholine receptor subunit beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100411,"[""Olfactory receptor 52B2""]",,"An olfactory receptor 52B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 52B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100411,,,,https://pharos.nih.gov/idg/targets/Q96RD2,,,,,,,,,,,,,OR52B2,,,Q96RD2,,,,,,,,Olfactory receptor 52B2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200352,"[""MYO3B gene""]",,"This gene encodes one of the class III myosins. Myosins are ATPases, activated by actin, that move along actin filaments in the cell. This class of myosins are characterized by an amino-terminal kinase domain and shown to be present in photoreceptors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400298,,,,,,,,"This gene encodes one of the class III myosins. Myosins are ATPases, activated by actin, that move along actin filaments in the cell. This class of myosins are characterized by an amino-terminal kinase domain and shown to be present in photoreceptors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200352,,,,,,,,,,,,,,,,140469,MYO3B,,,,,,,,,,,MYO3B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100113,"[""Gamma-aminobutyric acid receptor subunit beta-1""]",,"A gamma-aminobutyric acid receptor subunit beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P18505] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300512,,,,,,,,"A gamma-aminobutyric acid receptor subunit beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P18505] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100113,,,,https://pharos.nih.gov/idg/targets/P18505,,,,,,,,,,,,,GABRB1,,,P18505,,,,,,,,Gamma-aminobutyric acid receptor subunit beta-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80244,"[""Urotensin II""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16016,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80244,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80244,,,,,Urotensin II,,CHEBI:80244,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000188,"[""Desulfated cholecystokinin-8""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000188,,,,,,,,,,,,,,,,,,,,,,,,,,,,Desulfated cholecystokinin-8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000702,"[""L-1210 cell""]",,"Mouse lymphocytic leukemia established from the methylcholanthrene-induced tumor in a DBA strain mouse (subline 212, 8-month-old female) in 1949; the cells were propagated by heterotransplantation into DBA/2 mice; an in-vitro suspension culture was first reported in 1966; cells are used for cytotoxicity studies.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000741,,,,,,,,"Mouse lymphocytic leukemia established from the methylcholanthrene-induced tumor in a DBA strain mouse (subline 212, 8-month-old female) in 1949; the cells were propagated by heterotransplantation into DBA/2 mice; an in-vitro suspension culture was first reported in 1966; cells are used for cytotoxicity studies.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000702,,,,,,,BrendaTissueOBO,L1210 cell,BTO:0000702,,,,,,,,,,,,,,,,,,,L-1210 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200317,"[""TPCN1 gene""]",,"Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400481,,,,,,,,"Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200317,,,,,,,,,,,,,,,,53373,TPCN1,KIAA1169|TPC1,,,,,,,,,,TPCN1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217558,"[""NR2F1 gene""]",,"The protein encoded by this gene is a nuclear hormone receptor and transcriptional regulator. The encoded protein acts as a homodimer and binds to 5'-AGGTCA-3' repeats. Defects in this gene are a cause of Bosch-Boonstra optic atrophy syndrome (BBOAS). [provided by RefSeq, Apr 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_00217471,,,,,,,,"The protein encoded by this gene is a nuclear hormone receptor and transcriptional regulator. The encoded protein acts as a homodimer and binds to 5'-AGGTCA-3' repeats. Defects in this gene are a cause of Bosch-Boonstra optic atrophy syndrome (BBOAS). [provided by RefSeq, Apr 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217558,,,,,,,,,,,,,,,,7025,NR2F1,EAR3|ERBAL3|TFCOUP1,,,,,,,,,,NR2F1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_7998,"[""hyperthyroidism""]",,A thyroid gland disease that involves an over production of thyroid hormone.,false,,,http://purl.obolibrary.org/obo/DOID_50,,,,,,,,A thyroid gland disease that involves an over production of thyroid hormone.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:7998,,,,ICD10CM:E05.9|ORDO:99819|UMLS_CUI:C0020550|MESH:D006980|NCI:C3123|SNOMEDCT_US_2016_03_01:190239004|SNOMEDCT_US_2016_03_01:267464006|OMIM:609152|SNOMEDCT_US_2016_03_01:154655004|SNOMEDCT_US_2016_03_01:34486009|OMIM:603373,overactive thyroid,,disease_ontology,,DOID:7998,,,,,,,,,,,,,,,,,Xref MGI.,,hyperthyroidism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200035,"[""CACNA2D2 gene""]",,"Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_01400332,,,,,,,,"Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200035,,,,,,,,,,,,,,,,9254,CACNA2D2,KIAA0558,,,,,,,,,,CACNA2D2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100170,"[""G-protein coupled bile acid receptor 1""]",,"A G-protein coupled bile acid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDU6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300055,,,,,,,,"A G-protein coupled bile acid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDU6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100170,,,,https://pharos.nih.gov/idg/targets/Q8TDU6,,,,,,,,,,,,,GPBAR1,TGR5,,Q8TDU6,,,,,,,,G-protein coupled bile acid receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10588,"[""adrenoleukodystrophy""]",,"A leukodystrophy that disrupts the breakdown of very-long-chain fatty acids resulting in progressive brain damage, failure of the adrenal glands and eventually death.",false,,,http://purl.obolibrary.org/obo/DOID_10579,,,,,,,,"A leukodystrophy that disrupts the breakdown of very-long-chain fatty acids resulting in progressive brain damage, failure of the adrenal glands and eventually death.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10588,,,DOID:13451,SNOMEDCT_US_2016_03_01:267702006|SNOMEDCT_US_2016_03_01:192932009|ICD9CM:341.1|ICD10CM:E71.52|MESH:D000326|NCI:C61252|NCI:C84670|SNOMEDCT_US_2016_03_01:49692006|ICD10CM:G37.0|OMIM:300100|SNOMEDCT_US_2016_03_01:44875002|UMLS_CUI:C0007795|SNOMEDCT_US_2016_03_01:65389002|MESH:D002549|SNOMEDCT_US_2016_03_01:155059003|ICD10CM:E71.529|OMIM:202370|UMLS_CUI:C0162309,"Encephalitis periaxialis concentrica|X-linked adrenoleukodystrophy|SUDANOPHILIC CEREBRAL SCLEROSIS|Bronze Schilder disease|Siemerling-Creutzfeldt Disease|Encephalitis periaxialis, Schilder's|ALD|diffuse sclerosis|Schilder disease",,disease_ontology,diffuse cerebral sclerosis of Schilder|Schilder's disease,DOID:10588,,,,,,,,,,,,,,,,,MESH:D000326w added from NeuroDevNet [WAK].,,adrenoleukodystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10587,"[""Krabbe disease""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_1927,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10587,,,,ICD10CM:E75.23|SNOMEDCT_US_2016_03_01:5710006|SNOMEDCT_US_2016_03_01:189979005|SNOMEDCT_US_2016_03_01:192782005|NCI:C61254|UMLS_CUI:C0023521|OMIM:245200|MESH:D007965,GLOBOID CELL LEUKOENCEPHALOPATHY|Galactosylceramide beta-galactosidase deficiency (disorder)|Diffuse globoid body sclerosis|beta galactocerebrosidase deficiency|Krabbe's leukodystrophy|globoid cell leukodystrophy|Krabbe's disease,,disease_ontology,,DOID:10587,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Krabbe disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10581,"[""metachromatic leukodystrophy""]",,"A sphingolipidosis characterized by the accumulation of sulfatides in cells, especially the myelin producing cells of the nervous system.",false,,,http://purl.obolibrary.org/obo/DOID_1927,,,,,,,,"A sphingolipidosis characterized by the accumulation of sulfatides in cells, especially the myelin producing cells of the nervous system.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10581,,,,SNOMEDCT_US_2016_03_01:396338004|SNOMEDCT_US_2016_03_01:44359008|UMLS_CUI:C0023522|NCI:C61251|OMIM:249900|SNOMEDCT_US_2016_03_01:3621006|ICD10CM:E75.25|SNOMEDCT_US_2016_03_01:192784006|OMIM:250100|MESH:D007966|ICD10CM:E75.29|ORDO:512,Scholz cerebral sclerosis|deficiency of cerebroside-sulfatase|MLD|arylsulfatase A deficiency|sulfatide lipoidosis,,disease_ontology,,DOID:10581,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,metachromatic leukodystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10584,"[""retinitis pigmentosa""]",,A retinal degeneration characterized by the gradual deterioration of the photoreceptors or the retinal pigment epithelium of the retina leading to progressive sight loss.,false,,,http://purl.obolibrary.org/obo/DOID_8466,,,,,,,,A retinal degeneration characterized by the gradual deterioration of the photoreceptors or the retinal pigment epithelium of the retina leading to progressive sight loss.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10584,,,DOID:14742,ORDO:791|UMLS_CUI:C0035334|UMLS_CUI:C0220701|MESH:D012174|ICD10CM:H35.52|NCI:C85045|MESH:C538365|SNOMEDCT_US_2016_03_01:28835009|SNOMEDCT_US_2016_03_01:155113002|OMIM:268000,retinitis pigmentosa type 53 |retinitis pigmentosa type 59|pericentral pigmentary retinopathy|retinitis pigmentosa-1,,disease_ontology,,DOID:10584,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [LS].",,retinitis pigmentosa,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100437,"[""Interferon-inducible double-stranded rna-dependent protein kinase activator a""]",,"An interferon-inducible double-stranded RNA-dependent protein kinase activator A that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75569] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,"An interferon-inducible double-stranded RNA-dependent protein kinase activator A that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75569] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100437,,,,https://pharos.nih.gov/idg/targets/O75569,,,,,,,,,,,,,PRKRA,PACT|RAX,,O75569,,,,,,,,Interferon-inducible double-stranded rna-dependent protein kinase activator a,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300372,"[""Transmembrane channel (TMC) family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300372,,,,,,,,,,,,,,,,,,,,,,,,,,,,Transmembrane channel (TMC) family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3878,"[""intestinal pseudo-obstruction""]",,,false,,,http://purl.obolibrary.org/obo/DOID_8440,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3878,,,,UMLS_CUI:C0021847|SNOMEDCT_US_2016_03_01:235825006|NCI:C34733|MESH:D007418,intestine pseudoobstruction|Pseudo-obstruction of intestine (disorder)|intestinal Pseudo-obstruction,,disease_ontology,,DOID:3878,,,,,,,,,,,,,,,,,,,intestinal pseudo-obstruction,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200201,"[""AK2 gene""]",,"Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[provided by RefSeq, Nov 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03491004,,,,,,,,"Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[provided by RefSeq, Nov 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200201,,,,,,,,,,,,,,,,204,AK2,ADK2,,,,,,,,,,AK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400593,"[""TRPV4 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400484,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400593,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPV4 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000260,"[""MAPKAPK5 kinase domain""]",,Mitogen-activated protein kinase-activated protein kinase 5; MAPKAPK5; PRAK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase-activated protein kinase 5; MAPKAPK5; PRAK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000260,,,,,,,,,,,,,,,,,,,200245,,,,,,,,,MAPKAPK5 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000293,"[""MRCKA kinase domain""]",,CDC42 binding protein kinase alpha (DMPK-like); CDC42BPA; DKFZp686L1738; DKFZp686P1738; FLJ23347; KIAA0451; MRCK; MRCKA; PK428,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,CDC42 binding protein kinase alpha (DMPK-like); CDC42BPA; DKFZp686L1738; DKFZp686P1738; FLJ23347; KIAA0451; MRCK; MRCKA; PK428,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000293,,,,,,,,,,,,,,,,,,,200270,,,,,,,,,MRCKA kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10080,"[""sparganosis""]",,"A parasitic helminthiasis infectious disease that involves parasitic infection by the genus Spirometra. A painful nodule develops after the plerocercoid larvae migrate to the brain causing cerebral sparganosis. Subcutaneous tissue, breast, orbit, urinary tract, pleural cavity, lungs, abdominal viscera and inner ear can be infected.",false,,,http://purl.obolibrary.org/obo/DOID_883,,,,,,,,"A parasitic helminthiasis infectious disease that involves parasitic infection by the genus Spirometra. A painful nodule develops after the plerocercoid larvae migrate to the brain causing cerebral sparganosis. Subcutaneous tissue, breast, orbit, urinary tract, pleural cavity, lungs, abdominal viscera and inner ear can be infected.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10080,,,,ICD9CM:123.5|MESH:D013031|NCI:C35030|SNOMEDCT_US_2016_03_01:187152002|SNOMEDCT_US_2016_03_01:31659000|UMLS_CUI:C0037753|ICD10CM:B70.1,Infection by Sparganum|Sparganosis [larval diphyllobothriasis],,disease_ontology,,DOID:10080,,,,,,,,,,,,,,,,,,,sparganosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117479,"[""Nuclear receptor subfamily 0 group b member 2""]",,"A nuclear receptor subfamily 0 group B member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15466] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117459,,,,,,,,"A nuclear receptor subfamily 0 group B member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15466] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117479,,,,https://pharos.nih.gov/idg/targets/Q15466,,,,,,,,,,,,,NR0B2,,,Q15466,,,,,,,,Nuclear receptor subfamily 0 group b member 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003863,"[""CCF-STTG1 cell""]",,Human brain grade IV astrocytoma cell line; established from a 68-years-old caucasian female.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000101,,,,,,,,Human brain grade IV astrocytoma cell line; established from a 68-years-old caucasian female.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003863,,,,,,,BrendaTissueOBO,,BTO:0003863,,,,,,,,,,,,,,,,,,,CCF-STTG1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200209,"[""GPR78 gene""]",,"A G-protein coupled receptor 78 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P69] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 78 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96P69] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200209,,,,,,,,,,,,,,,,27201,GPR78,,,,,,,,,,,GPR78 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2531,"[""hematologic cancer""]",,"An immune system cancer located_in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes.",false,,,http://purl.obolibrary.org/obo/DOID_0060083,,,,,,,,"An immune system cancer located_in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2531,,,DOID:1034|DOID:2532,UMLS_CUI:C0376544|NCI:C27134|MESH:D019337|SNOMEDCT_US_2016_03_01:414388001|SNOMEDCT_US_2016_03_01:414644002,hematopoietic tumors|Hematologic malignancy|Hematologic malignancy (disorder)|hematopoietic neoplasm (morphologic abnormality)|hematopoietic and lymphoid system tumor|hematopoietic cancer|Hematological tumors|blood cancer|malignant hematopoietic neoplasm (morphologic abnormality)|Hematologic neoplasm (disorder),,disease_ontology,,DOID:2531,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,hematologic cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100039,"[""Activin receptor type-2b""]",,"activin receptor type-2b (ACVR2B)  with  no mutation  in a nonphosphorylated state|An activin receptor type-2B that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13705] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300252,,,,,,,,"activin receptor type-2b (ACVR2B)  with  no mutation  in a nonphosphorylated state|An activin receptor type-2B that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13705] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100039,,,,https://pharos.nih.gov/idg/targets/Q13705,,,,,,,,,,,,,ACVR2B,,,Q13705,,,,,,,,Activin receptor type-2b,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001247,"[""sieve tube""]",,"Found in phloem tissue, sieve tubes lack a nucleus, and are thought to be responsible for the translocation of material across the phloem tissue.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Found in phloem tissue, sieve tubes lack a nucleus, and are thought to be responsible for the translocation of material across the phloem tissue.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001247,,,,,,,BrendaTissueOBO,,BTO:0001247,,,,,,,,,,,,,,,,,,,sieve tube,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200314,"[""OR10J4 gene""]",,"An olfactory receptor 10J4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C629] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10J4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C629] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200314,,,,,,,,,,,,,,,,391121,OR10J4,OR10J4P,,,,,,,,,,OR10J4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000452,"[""fibroblast""]",,A connective-tissue cell of mesenchymal origin that secretes proteins and especially molecular collagen from which the extracellular fibrillar matrix of connective tissue forms.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000421,,,,,,,,A connective-tissue cell of mesenchymal origin that secretes proteins and especially molecular collagen from which the extracellular fibrillar matrix of connective tissue forms.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000452,,,,,,,BrendaTissueOBO,,BTO:0000452,,,,,,,,,,,,,,,,,,,fibroblast,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100165,"[""Inositol 1,4,5-trisphosphate receptor type 1""]",,"An inositol 1,4,5-trisphosphate receptor type 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14643] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300354,,,,,,,,"An inositol 1,4,5-trisphosphate receptor type 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14643] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100165,,,,https://pharos.nih.gov/idg/targets/Q14643,,,,,,,,,,,,,ITPR1,INSP3R1,,Q14643,,,,,,,,"Inositol 1,4,5-trisphosphate receptor type 1",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100054,"[""T351 in ABL1(M351T)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100054,,,,,,,,,,,,,,,,,,,,,,,,,,,,T351 in ABL1(M351T),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3512,"[""neurofibrosarcoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_962,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3512,,,,UMLS_CUI:C0206729|MESH:D018319|SNOMEDCT_US_2016_03_01:404037002|SNOMEDCT_US_2016_03_01:19897006,Neurosarcoma [obs],,disease_ontology,,DOID:3512,,,,,,,,,,,,,,,,,,,neurofibrosarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005499,"[""NYH cell""]",,Human small cell lung cancer cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002206,,,,,,,,Human small cell lung cancer cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005499,XPMUser,2013-09-11T09:42:44Z,,,,,BrendaTissueOBO,,BTO:0005499,,,,,,,,,,,,,,,,,,,NYH cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000079,"[""[des-Arg10]kallidin""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000079,,,,,,,,,,,,,,,,,,,,,,,,,,,,[des-Arg10]kallidin,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100762,"[""Relaxin receptor 2""]",,"A relaxin receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8WXD0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A relaxin receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8WXD0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100762,,,,https://pharos.nih.gov/idg/targets/Q8WXD0,,,,,,,,,,,,,RXFP2,GPR106|GREAT|LGR8,,Q8WXD0,,,,,,,,Relaxin receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8577,"[""ulcerative colitis""]",,"A colitis that is predominantly confined to the mucosa located_in colon and includes characteristic ulcers, or open sores.",false,,,http://purl.obolibrary.org/obo/DOID_0060180,,,,,,,,"A colitis that is predominantly confined to the mucosa located_in colon and includes characteristic ulcers, or open sores.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8577,,,DOID:9016|DOID:8576,SNOMEDCT_US_2016_03_01:196988003|EFO:0000729|UMLS_CUI:C0009324|ICD9CM:556|SNOMEDCT_US_2016_03_01:68195006|SNOMEDCT_US_2016_03_01:441971007|SNOMEDCT_US_2016_03_01:27701000|SNOMEDCT_US_2016_03_01:196996008|SNOMEDCT_US_2016_03_01:266447004|ICD10CM:K51|NCI:C2952|ICD10CM:K51.9|SNOMEDCT_US_2016_03_01:196985000|UMLS_CUI:C0375359|ICD9CM:556.9|SNOMEDCT_US_2016_03_01:155764007|MESH:D003093|OMIM:266600|SNOMEDCT_US_2016_03_01:64766004|ICD9CM:556.5,Left-sided ulcerative colitis,,disease_ontology,,DOID:8577,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,ulcerative colitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200174,"[""GPRC5D gene""]",,"A G-protein coupled receptor family C group 5 member D that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZD1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400004,,,,,,,,"A G-protein coupled receptor family C group 5 member D that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZD1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200174,,,,,,,,,,,,,,,,55507,GPRC5D,,,,,,,,,,,GPRC5D gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003472,"[""vagus nerve""]",,Either of the 10th pair of cranial nerves that arise from the medulla and supply chiefly the viscera especially with autonomic sensory and motor fibers.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001104,,,,,,,,Either of the 10th pair of cranial nerves that arise from the medulla and supply chiefly the viscera especially with autonomic sensory and motor fibers.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003472,,,,,,,BrendaTissueOBO,tenth cranial nerve|cranial nerve X|vagus|pneuomgastric nerve|nervus vagus,BTO:0003472,,,,,,,,,,,,,,,,,,,vagus nerve,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000137,"[""MET167 in NDR2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000137,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET167 in NDR2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100118,"[""Gastrin/cholecystokinin type B receptor""]",,"A cholecystokinin receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32239] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300030,,,,,,,,"A cholecystokinin receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32239] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100118,,,,https://pharos.nih.gov/idg/targets/P32239,,,,,,,,,,,,,CCKBR,CCKRB,,P32239,,,,,,,,Gastrin/cholecystokinin type B receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400147,"[""DCAMKL family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400147,,,,,,,,,,,,,,,,,,,,,,,,,,,,DCAMKL family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200061,"[""CCR9 gene""]",,"A C-C chemokine receptor type 9 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51686] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400095,,,,,,,,"A C-C chemokine receptor type 9 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51686] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200061,,,,,,,,,,,,,,,,10803,CCR9,GPR28,,,,,,,,,,CCR9 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100573,"[""Olfactory receptor 4C12""]",,"An olfactory receptor 4C12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R67] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4C12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R67] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100573,,,,https://pharos.nih.gov/idg/targets/Q96R67,,,,,,,,,,,,,OR4C12,,,Q96R67,,,,,,,,Olfactory receptor 4C12,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100572,"[""Tyrosine-protein kinase zap-70""]",,"A tyrosine-protein kinase ZAP-70 that is encoded in the genome of human. [PRO:CL, UniProtKB:P43403] |tyrosine-protein kinase zap-70 (ZAP70)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300180,,,,,,,,"A tyrosine-protein kinase ZAP-70 that is encoded in the genome of human. [PRO:CL, UniProtKB:P43403] |tyrosine-protein kinase zap-70 (ZAP70)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100572,,,,https://pharos.nih.gov/idg/targets/P43403,,,,,,,,,,,,,ZAP70,SRK,,P43403,,,,,,,,Tyrosine-protein kinase zap-70,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400431,"[""KCNJ4 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400431,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ4 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004223,"[""cervical squamous cell carcinoma cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001289|http://purl.obolibrary.org/obo/BTO_0000180,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004223,,,,,,,BrendaTissueOBO,squamous cell cervical carcinoma cell|SCCC cell,BTO:0004223,,,,,,,,,,,,,,,,,,,cervical squamous cell carcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000045,"[""adrenal cortex""]",,"The outer portion of the adrenal glands that produces several steroid hormones, including cortisol and aldosterone.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The outer portion of the adrenal glands that produces several steroid hormones, including cortisol and aldosterone.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000045,,,,,,,BrendaTissueOBO,cortex glandulae suprarenalis|suprarenal cortex|cortex of adrenal gland|cortex of suprarenal gland,BTO:0000045,,,,,,,,,,,,,,,,,,,adrenal cortex,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100391,"[""Pantothenate kinase 1""]",,"A pantothenate kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TE04] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391028,,,,,,,,"A pantothenate kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TE04] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100391,,,,https://pharos.nih.gov/idg/targets/Q8TE04,,,,,,,,,,,,,PANK1,PANK,,Q8TE04,,,,,,,,Pantothenate kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_29108,"[""calcium(2+)""]","InChI=1S/Ca/q+2|Ca(2+)|Calcium element|CALCIUM ION|calcium, doubly charged positive ion|calcium|Ca|[Ca++]|BHPQYMZQTOCNFJ-UHFFFAOYSA-N|Ca2+",A calcium cation that has formula Ca.,false,,,http://purl.obolibrary.org/obo/CHEBI_36916,,,,,,,CiteXplore:15885294|CiteXplore:16718844|NIST Chemistry WebBook:14127-61-8|KEGG COMPOUND:C00076|MetaCyc:CA%2b2|HMDB:HMDB00464|Gmelin:6850|ChemIDplus:14127-61-8|PDBeChem:CA|Wikipedia:Calcium|CiteXplore:11683549|CiteXplore:16034903|CiteXplore:9278463|CiteXplore:24023812|CiteXplore:297449|CiteXplore:22546835|CiteXplore:16704554|CiteXplore:15671236|CiteXplore:15860827|CiteXplore:16244393|CiteXplore:16481635,A calcium cation that has formula Ca.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:3308|CHEBI:22988|CHEBI:48760,,calcium(2+)|calcium(II) cation|calcium(2+) ion,,chebi_ontology,"InChI=1S/Ca/q+2|Ca(2+)|Calcium element|CALCIUM ION|calcium, doubly charged positive ion|calcium|Ca|[Ca++]|BHPQYMZQTOCNFJ-UHFFFAOYSA-N|Ca2+",,,CHEBI:29108,,,,,,,,,,,,,,,,,,,,,,,CHEBI:29108,,,,,calcium(2+),,CHEBI:29108,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100005,"[""5-hydroxytryptamine receptor 1f""]",,"A 5-hydroxytryptamine receptor 1F that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30939] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302001,,,,,,,,"A 5-hydroxytryptamine receptor 1F that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30939] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100005,,,,https://pharos.nih.gov/idg/targets/P30939,,,,,,,,,,,,,HTR1F,HTR1EL,,P30939,,,,,,,,5-hydroxytryptamine receptor 1f,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100364,"[""Nf-kappa-b essential modulator""]",,An NF-kappa-B essential modulator that is encoded in the genome of human. ,false,,,http://www.drugtargetontology.org/dto/DTO_03300102,,,,,,,,An NF-kappa-B essential modulator that is encoded in the genome of human. ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100364,,,,https://pharos.nih.gov/idg/targets/Q9Y6K9,,,,,,,,,,,,,IKBKG,FIP3|NEMO,,Q9Y6K9,,,,,,,,Nf-kappa-b essential modulator,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000608,"[""hepatoma cell""]",,"Primary carcinoma of the liver cells. It ranges from a well-differentiated tumour difficult to distinguish from normal hepatocytes to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic or may form giant cells. Several classification schemes have been suggested. Hepatocellular carcinoma is very rare in the united states and western europe, but it is one of the most common cancers in eastern asia and sub-saharan africa. The cases are preponderantly male and, racially, whites have the lowest rates.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000594|http://purl.obolibrary.org/obo/BTO_0000604,,,,,,,,"Primary carcinoma of the liver cells. It ranges from a well-differentiated tumour difficult to distinguish from normal hepatocytes to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic or may form giant cells. Several classification schemes have been suggested. Hepatocellular carcinoma is very rare in the united states and western europe, but it is one of the most common cancers in eastern asia and sub-saharan africa. The cases are preponderantly male and, racially, whites have the lowest rates.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000608,,,,,,,BrendaTissueOBO,hepatocarcinoma cell|hepatic carcinoma cell|HCC cell|hepatocellular carcinoma cell|liver adenocarcinoma cell|hepatic cancer cell|hepatocellular adenocarcinoma cell,BTO:0000608,,,,,,,,,,,,,,,,,,,hepatoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003096,"[""internal male genital organ""]",,"The internal organs in the male that are concerned with reproduction, including the testis, epididymis, ductus deferens, seminal vesicle, ejaculatory duct, prostate, and bulbourethral gland.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The internal organs in the male that are concerned with reproduction, including the testis, epididymis, ductus deferens, seminal vesicle, ejaculatory duct, prostate, and bulbourethral gland.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003096,,,,,,,BrendaTissueOBO,organa genitalia masculina interna,BTO:0003096,,,,,,,,,,,,,,,,,,,internal male genital organ,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002202,"[""lung squamous cell carcinoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000762|http://purl.obolibrary.org/obo/BTO_0002024,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002202,,,,,,,BrendaTissueOBO,,BTO:0002202,,,,,,,,,,,,,,,,,,,lung squamous cell carcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001160,"[""red bone marrow""]",,"Marrow of developing bone, of the ribs, vertebrae, and many of the smaller bones; it is the site of production of erythrocytes and granular leukocytes.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000141|http://purl.obolibrary.org/obo/BTO_0004850,,,,,,,,"Marrow of developing bone, of the ribs, vertebrae, and many of the smaller bones; it is the site of production of erythrocytes and granular leukocytes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001160,,,,,,,BrendaTissueOBO,red marrow|medulla ossium rubra,BTO:0001160,,,,,,,,,,,,,,,,,,,red bone marrow,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00400002,"[""Tchem""]",,"These targets have activities in ChEMBL or DrugCentral that satisfy the activity thresholds detailed below. In some cases, targets have been manually migrated to Tchem by human curation based on small molecule activities from other sources.|Tchem",false,,,http://www.drugtargetontology.org/dto/DTO_00400001,,,,,,,,"These targets have activities in ChEMBL or DrugCentral that satisfy the activity thresholds detailed below. In some cases, targets have been manually migrated to Tchem by human curation based on small molecule activities from other sources.|Tchem",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,Tchem,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003899,"[""GT1-1 cell""]",,Immortalized GnRH secreting mouse neuronal cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0000947|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Immortalized GnRH secreting mouse neuronal cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003899,,,,,,,BrendaTissueOBO,,BTO:0003899,,,,,,,,,,,,,,,,,,,GT1-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004351,"[""lateral posterior nucleus""]",,"A narrow strip of cell groups on the dorsomedial surface of the thalamus. It includes the lateral dorsal nucleus, lateral posterior nucleus, and the PULVINAR.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A narrow strip of cell groups on the dorsomedial surface of the thalamus. It includes the lateral dorsal nucleus, lateral posterior nucleus, and the PULVINAR.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004351,,,,,,,BrendaTissueOBO,,BTO:0004351,,,,,,,,,,,,,,,,,,,lateral posterior nucleus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100760,"[""Relaxin-3 receptor 2""]",,"A relaxin-3 receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDU9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A relaxin-3 receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDU9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100760,,,,https://pharos.nih.gov/idg/targets/Q8TDU9,,,,,,,,,,,,,RXFP4,GPR100|RLN3R2,,Q8TDU9,,,,,,,,Relaxin-3 receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3856,"[""male reproductive organ cancer""]",,A reproductive organ cancer that is manifested in the male genital system. This includes organs such as the penis and scrotum.,false,,,http://purl.obolibrary.org/obo/DOID_193,,,,,,,,A reproductive organ cancer that is manifested in the male genital system. This includes organs such as the penis and scrotum.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3856,,,DOID:10284,ICD10CM:C60-C63|ICD9CM:187.9|UMLS_CUI:C0017417|SNOMEDCT_US_2016_03_01:363515000|UMLS_CUI:C0153606|ICD10CM:C63.9|MESH:D005834|SNOMEDCT_US_2016_03_01:126895004|NCI:C3054|SNOMEDCT_US_2016_03_01:190130007|NCI:C8561|SNOMEDCT_US_2016_03_01:190127000|SNOMEDCT_US_2016_03_01:93885006,"malignant tumor of male genital organ|malignant tumor of male genital organ (disorder)|neoplasm of male genital organ|malignant neoplasm of male genital organ, site unspecified|male genital cancer|malignant neoplasm of male genital organ, NOS|male reproductive system neoplasm|malignant neoplasm of male genital organ, unspecified (disorder)|malignant neoplasm of male genital organ or tract|tumor of male Reproductive system|malignant tumor of male Reproductive system|malignant neoplasm of male genital organs (disorder)",,disease_ontology,male genital neoplasm,DOID:3856,,,,,,,,,,,,,,,,,,,male reproductive organ cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2508,"[""Takayasu's arteritis""]",,A syndrome that involves inflammation of the aorta that carries blood from the heart to the rest of the body.,false,,,http://purl.obolibrary.org/obo/DOID_0050828|http://purl.obolibrary.org/obo/DOID_225,,,,,,,,A syndrome that involves inflammation of the aorta that carries blood from the heart to the rest of the body.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2508,,,DOID:13377,MESH:D001015|ICD9CM:446.7|SNOMEDCT_US_2016_03_01:359789008|NCI:C34391|SNOMEDCT_US_2016_03_01:155445002|MESH:D013625|UMLS_CUI:C0003490|SNOMEDCT_US_2016_03_01:42153001|UMLS_CUI:C0039263|ICD10CM:M31.4|OMIM:207600|SNOMEDCT_US_2016_03_01:266323005|NCI:C35062|SNOMEDCT_US_2016_03_01:195361009,Takayasu arteritis|Aortic arch arteritis|Aortic arch syndrome|(Aortic arch arteritis) or (Takayasu's disease[& pulseless])|Idiopathic aortitis (disorder)|Aortic Arch syndrome|Takayasu's disease,,disease_ontology,,DOID:2508,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Takayasu's arteritis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200165,"[""GSK3B gene""]",,"The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400272,,,,,,,,"The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200165,,,,,,,,,,,,,,,,2932,GSK3B,,,,,,,,,,,GSK3B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100384,"[""Serine/threonine-protein kinase pak 1""]",,"serine/threonine-protein kinase pak 1 (PAK1)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase PAK 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13153] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300303,,,,,,,,"serine/threonine-protein kinase pak 1 (PAK1)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase PAK 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13153] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100384,,,,https://pharos.nih.gov/idg/targets/Q13153,,,,,,,,,,,,,PAK1,,,Q13153,,,,,,,,Serine/threonine-protein kinase pak 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001886,"[""primordium""]",,The rudiment or commencement of a part or organ.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000174,,,,,,,,The rudiment or commencement of a part or organ.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001886,,,,,,,BrendaTissueOBO,,BTO:0001886,,,,,,,,,,,,,,,,,,,primordium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200817,"[""AVPR2 gene""]",,"A vasopressin V2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30518] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A vasopressin V2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30518] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200817,,,,,,,,,,,,,,,,554,AVPR2,ADHR|DIR|DIR3|V2R,,,,,,,,,,AVPR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400565,"[""Kv7.5/KCNQ5 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400449,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400565,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv7.5/KCNQ5 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100160,"[""Probable G-protein coupled receptor 160""]",,"A G-protein coupled receptor 160 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UJ42] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300052,,,,,,,,"A G-protein coupled receptor 160 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UJ42] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100160,,,,https://pharos.nih.gov/idg/targets/Q9UJ42,,,,,,,,,,,,,GPR160,GPCR150,,Q9UJ42,,,,,,,,Probable G-protein coupled receptor 160,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4330,"[""non-Langerhans-cell histiocytosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3405,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4330,,,,UMLS_CUI:C0019624|SNOMEDCT_US_2016_03_01:127069007|MESH:D015616,,,disease_ontology,,DOID:4330,,,,,,,,,,,,,,,,,,,non-Langerhans-cell histiocytosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200095,"[""FFAR2 gene""]",,"A free fatty acid receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O15552] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400040,,,,,,,,"A free fatty acid receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O15552] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200095,,,,,,,,,,,,,,,,2867,FFAR2,FFA2|GPCR43|GPR43,,,,,,,,,,FFAR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001292,"[""sporozoite""]",,A usually motile infective form of some sporozoans that is a product of sporogony and initiates an asexual cycle in the new host.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000749,,,,,,,,A usually motile infective form of some sporozoans that is a product of sporogony and initiates an asexual cycle in the new host.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001292,,,,,,,BrendaTissueOBO,,BTO:0001292,,,,,,,,,,,,,,,,,,,sporozoite,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300027,"[""Anaphylatoxin receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300027,,,,,,,,,,,,,,,,,,,,,,,,,,,,Anaphylatoxin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000645,"[""colon sigmoideum""]",,"The S-shaped part of the colon which lies in the pelvis, extending from the pelvic brim to the third segment of the sacrum, and continuous above with the descending (or iliac) colon and below with the rectum.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The S-shaped part of the colon which lies in the pelvis, extending from the pelvic brim to the third segment of the sacrum, and continuous above with the descending (or iliac) colon and below with the rectum.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000645,,,,,,,BrendaTissueOBO,pelvic colon|sigmoid colon|sigmoid flexure,BTO:0000645,,,,,,,,,,,,,,,,,,,colon sigmoideum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004479,"[""MV4-11 cell""]",,Human acute myelocytic leukemia cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0001883|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human acute myelocytic leukemia cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004479,Marion,2010-02-04T11:07:29Z,,,,,BrendaTissueOBO,,BTO:0004479,,,,,,,,,,,,,,,,,,,MV4-11 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100097,"[""Free fatty acid receptor 4""]",,"A free fatty acid receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q5NUL3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300040,,,,,,,,"A free fatty acid receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q5NUL3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100097,,,,https://pharos.nih.gov/idg/targets/Q5NUL3,,,,,,,,,,,,,FFAR4,GPR120|GPR129|O3FAR1|PGR4,,Q5NUL3,,,,,,,,Free fatty acid receptor 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300362,"[""Membrane protein mlc1 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300362,,,,,,,,,,,,,,,,,,,,,,,,,,,,Membrane protein mlc1 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200224,"[""KCNK15 gene""]",,"This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400359,,,,,,,,"This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200224,,,,,,,,,,,,,,,,60598,KCNK15,TASK5,,,,,,,,,,KCNK15 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9620,"[""vesicoureteral reflux""]",,A ureteral disease characterized by backward flow of urine from the urinary bladder into the ureter.,false,,,http://purl.obolibrary.org/obo/DOID_1426,,,,,,,,A ureteral disease characterized by backward flow of urine from the urinary bladder into the ureter.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9620,,,,SNOMEDCT_US_2016_03_01:26836002|ICD10CM:N13.7|OMIM:615390|OMIM:193000|OMIM:615963|ORDO:289365|SNOMEDCT_US_2016_03_01:155875004|SNOMEDCT_US_2016_03_01:251994004|OMIM:614319|OMIM:614318|MESH:D014718|OMIM:610878|UMLS_CUI:C0042580|OMIM:613674|OMIM:614674|ICD9CM:593.7|SNOMEDCT_US_2016_03_01:197811007|OMIM:314550|OMIM:614317|NCI:C84467|ICD10CM:N13.70,vesico-ureteral reflux,,disease_ontology,,DOID:9620,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [LS].",,vesicoureteral reflux,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002484,"[""columnar cell""]",,An elongated epithelial cell.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000414,,,,,,,,An elongated epithelial cell.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002484,,,,,,,BrendaTissueOBO,columnar epithelial cell,BTO:0002484,,,,,,,,,,,,,,,,,,,columnar cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400515,"[""GABRD sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400515,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRD sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100174,"[""Homeodomain-interacting protein kinase 3""]",,"homeodomain-interacting protein kinase 3 (HIPK3)  with  no mutation  in a nonphosphorylated state|A homeodomain-interacting protein kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H422] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300273,,,,,,,,"homeodomain-interacting protein kinase 3 (HIPK3)  with  no mutation  in a nonphosphorylated state|A homeodomain-interacting protein kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H422] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100174,,,,https://pharos.nih.gov/idg/targets/Q9H422,,,,,,,,,,,,,HIPK3,DYRK6|FIST3|PKY,,Q9H422,,,,,,,,Homeodomain-interacting protein kinase 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5656,"[""cranial nerve disease""]",,A neuropathy that is located_in one of the twelve cranial nerves.,false,,,http://purl.obolibrary.org/obo/DOID_870,,,,,,,,A neuropathy that is located_in one of the twelve cranial nerves.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5656,,,,UMLS_CUI:C0010266|ICD9CM:352.9|SNOMEDCT_US_2016_03_01:193104009|SNOMEDCT_US_2016_03_01:276379008|SNOMEDCT_US_2016_03_01:267709002|SNOMEDCT_US_2016_03_01:267598004|NCI:C26733|MESH:D003389|SNOMEDCT_US_2016_03_01:73013002|ICD10CM:G52.9,disorder of cranial nerve|Cranial nerve disorder,,disease_ontology,,DOID:5656,,,,,,,,,,,,,,,,,,,cranial nerve disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001509,"[""umbilical vein""]",,A vein that passes through the umbilical cord to the fetus and returns the oxygenated and nutrient blood from the placenta to the fetus.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A vein that passes through the umbilical cord to the fetus and returns the oxygenated and nutrient blood from the placenta to the fetus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001509,,,,,,,BrendaTissueOBO,,BTO:0001509,,,,,,,,,,,,,,,,,,,umbilical vein,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200460,"[""ROR2 gene""]",,"The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors.  The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development.  Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400219,,,,,,,,"The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors.  The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development.  Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200460,,,,,,,,,,,,,,,,4920,ROR2,NTRKR2,,,,,,,,,,ROR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200592,"[""IP6K1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200592,,,,,,,,,,,,,,,,,,,,,,,,,,,,IP6K1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000067,"[""LEU210 in AURKA""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000067,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU210 in AURKA,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002513,"[""Ewing's sarcoma cell""]",,A malignant primary bone tumour that arises most commonly in the first three decades of life.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001207|http://purl.obolibrary.org/obo/BTO_0004255,,,,,,,,A malignant primary bone tumour that arises most commonly in the first three decades of life.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002513,,,,,,,BrendaTissueOBO,ETB cell|Ewing sarcoma cell|Ewing tumor cell|EWS cell|Ewing's sarcoma of bone|Ewing's tumor of bone,BTO:0002513,,,,,,,,,,,,,,,,,,,Ewing's sarcoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000261,"[""MARK1 kinase domain""]",,MAP/microtubule affinity-regulating kinase 1; KIAA1477; MARK; MARK1; MGC126512; MGC126513,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,MAP/microtubule affinity-regulating kinase 1; KIAA1477; MARK; MARK1; MGC126512; MGC126513,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000261,,,,,,,,,,,,,,,,,,,200246,,,,,,,,,MARK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200346,"[""MUSK gene""]",,"This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400195,,,,,,,,"This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200346,,,,,,,,,,,,,,,,4593,MUSK,,,,,,,,,,,MUSK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000601,"[""hippocampus""]",,"A curved elongated ridge that extends over the floor of the descending horn of each lateral ventricle of the brain and consists of gray matter covered on the ventricular surface with white matter; The hippocampus is a part of the temporal lobe, which has a well established role in learning, memory and emotion.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A curved elongated ridge that extends over the floor of the descending horn of each lateral ventricle of the brain and consists of gray matter covered on the ventricular surface with white matter; The hippocampus is a part of the temporal lobe, which has a well established role in learning, memory and emotion.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000601,,,,,,,BrendaTissueOBO,hippocampus major|major hippocampus,BTO:0000601,,,,,,,,,,,,,,,,,,,hippocampus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100194,"[""Potassium voltage-gated channel subfamily d member 2""]",,"A voltage-gated potassium channel KCND2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9NZV8] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300546,,,,,,,,"A voltage-gated potassium channel KCND2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9NZV8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100194,,,,https://pharos.nih.gov/idg/targets/Q9NZV8,,,,,,,,,,,,,KCND2,KIAA1044,,Q9NZV8,,,,,,,,Potassium voltage-gated channel subfamily d member 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200040,"[""CACNA1C gene""]",,"This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400383,,,,,,,,"This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200040,,,,,,,,,,,,,,,,775,CACNA1C,CACH2|CACN2|CACNL1A1|CCHL1A1,,,,,,,,,,CACNA1C gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004378,"[""blood vessel wall""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004378,,,,,,,BrendaTissueOBO,vascular wall,BTO:0004378,,,,,,,,,,,,,,,,,,,blood vessel wall,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200372,"[""NTRK2 gene""]",,"This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400200,,,,,,,,"This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200372,,,,,,,,,,,,,,,,4915,NTRK2,TRKB,,,,,,,,,,NTRK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100109,"[""Gamma-aminobutyric acid receptor subunit alpha-3""]",,"A gamma-aminobutyric acid receptor subunit alpha-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P34903] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300508,,,,,,,,"A gamma-aminobutyric acid receptor subunit alpha-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P34903] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100109,,,,https://pharos.nih.gov/idg/targets/P34903,,,,,,,,,,,,,GABRA3,,,P34903,,,,,,,,Gamma-aminobutyric acid receptor subunit alpha-3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3121,"[""gallbladder cancer""]",,A biliary tract cancer that is located_in the gallbladder.,false,,,http://purl.obolibrary.org/obo/DOID_0060262|http://purl.obolibrary.org/obo/DOID_4607,,,,,,,,A biliary tract cancer that is located_in the gallbladder.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3121,,,DOID:8090|DOID:8157,UMLS_CUI:C0016978|SNOMEDCT_US_2016_03_01:269550003|NCI:C7481|UMLS_CUI:C0278806|SNOMEDCT_US_2016_03_01:187782001|NCI:C35676|SNOMEDCT_US_2016_03_01:126854002|SNOMEDCT_US_2016_03_01:154472004|SNOMEDCT_US_2016_03_01:363353009|UMLS_CUI:C0153452|NCI:C3048|ICD9CM:156.0|ICD10CM:C23|SNOMEDCT_US_2016_03_01:254602009|SNOMEDCT_US_2016_03_01:93810008|MESH:D005706,malignant tumour of gallbladder|tumor of the gallbladder|malignant tumor of the gallbladder|malignant neoplasm of gallbladder|gallbladder Ca|localized malignant gallbladder neoplasm|gallbladder neoplasm,,disease_ontology,,DOID:3121,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,gallbladder cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200142,"[""ERN1 gene""]",,"The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400154,,,,,,,,"The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200142,,,,,,,,,,,,,,,,2081,ERN1,IRE1,,,,,,,,,,ERN1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100761,"[""Relaxin receptor 1""]",,"A relaxin receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HBX9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A relaxin receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HBX9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100761,,,,https://pharos.nih.gov/idg/targets/Q9HBX9,,,,,,,,,,,,,RXFP1,LGR7,,Q9HBX9,,,,,,,,Relaxin receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001803,"[""retrocerebral complex""]",,"Corpora allata with Corpora cardiaca form the retrocerebral complex, a neurosecretory organ.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001488,,,,,,,,"Corpora allata with Corpora cardiaca form the retrocerebral complex, a neurosecretory organ.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001803,,,,,,,BrendaTissueOBO,,BTO:0001803,,,,,,,,,,,,,,,,,,,retrocerebral complex,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100406,"[""Olfactory receptor 51T1""]",,"An olfactory receptor 51T1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 51T1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100406,,,,https://pharos.nih.gov/idg/targets/Q8NGJ9,,,,,,,,,,,,,OR51T1,,,Q8NGJ9,,,,,,,,Olfactory receptor 51T1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000031,"[""LEU115 in RPS6KA4(Kin.Dom.1-N-terminal)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000031,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU115 in RPS6KA4(Kin.Dom.1-N-terminal),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9341,"[""urethral diverticulum""]",,,false,,,http://purl.obolibrary.org/obo/DOID_732,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9341,,,,UMLS_CUI:C0152443|SNOMEDCT_US_2016_03_01:90531003|NCI:C39861|ICD9CM:599.2|ICD10CM:N36.1,,,disease_ontology,,DOID:9341,,,,,,,,,,,,,,,,,,,urethral diverticulum,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200088,"[""CNGA4 gene""]",,"CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001 [PubMed 11739959]).[supplied by OMIM, Mar 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400405,,,,,,,,"CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001 [PubMed 11739959]).[supplied by OMIM, Mar 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200088,,,,,,,,,,,,,,,,1262,CNGA4,,,,,,,,,,,CNGA4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100048,"[""Voltage-dependent L-type calcium channel subunit beta-1""]",,"A voltage-dependent L-type calcium channel subunit beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02641] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300334,,,,,,,,"A voltage-dependent L-type calcium channel subunit beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02641] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100048,,,,https://pharos.nih.gov/idg/targets/Q02641,,,,,,,,,,,,,CACNB1,CACNLB1,,Q02641,,,,,,,,Voltage-dependent L-type calcium channel subunit beta-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100200,"[""Adenylate kinase isoenzyme 1""]",,"An adenylate kinase isoenzyme 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00568] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391001,,,,,,,,"An adenylate kinase isoenzyme 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00568] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100200,,,,https://pharos.nih.gov/idg/targets/P00568,,,,,,,,,,,,,AK1,,,P00568,,,,,,,,Adenylate kinase isoenzyme 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200338,"[""MAP2K5 gene""]",,"The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400194,,,,,,,,"The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200338,,,,,,,,,,,,,,,,5607,MAP2K5,MEK5|MKK5|PRKMK5,,,,,,,,,,MAP2K5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000201,"[""JAK1(Kin.Dom.2) kinase domain""]",,Janus kinase 1; JAK1; JAK1~b; JAK1A; JAK1B; JAK1-pseudokinase; JTK3,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Janus kinase 1; JAK1; JAK1~b; JAK1A; JAK1B; JAK1-pseudokinase; JTK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000201,,,,,,,,,,,,,,,,,,,"200204, 200206",,,,,,,,,JAK1(Kin.Dom.2) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000534,"[""gonad""]",,A reproductive gland (as an ovary or testis) that produces gametes.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000254|http://purl.obolibrary.org/obo/BTO_0000080,,,,,,,,A reproductive gland (as an ovary or testis) that produces gametes.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000534,,,,,,,BrendaTissueOBO,,BTO:0000534,,,,,,,,,,,,,,,,,,,gonad,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000450,"[""fiber""]",,"An elongated tapering thick-walled plant cell void at maturity that imparts elasticity, flexibility, and tensile strength.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"An elongated tapering thick-walled plant cell void at maturity that imparts elasticity, flexibility, and tensile strength.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000450,,,,,,,BrendaTissueOBO,,BTO:0000450,,,,,,,,,,,,,,,,,American Cotton (Gossypium hirsutum).,,fiber,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200074,"[""CLCN3 gene""]",,"This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400397,,,,,,,,"This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200074,,,,,,,,,,,,,,,,1182,CLCN3,,,,,,,,,,,CLCN3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000667,"[""keratinocyte""]",,"Skin cell, of the keratinized layer of epidermis: its characteristic intermediate filament protein is cytokeratin. A cell of the stratum spinosum of the epidermis.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001470,,,,,,,,"Skin cell, of the keratinized layer of epidermis: its characteristic intermediate filament protein is cytokeratin. A cell of the stratum spinosum of the epidermis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000667,,,,,,,BrendaTissueOBO,malpighian cell,BTO:0000667,,,,,,,,,,,,,,,,,,,keratinocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117497,"[""Nuclear receptor subfamily 1 group i member 2""]",,"A nuclear receptor subfamily 1 group I member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75469] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117466,,,,,,,,"A nuclear receptor subfamily 1 group I member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75469] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117497,,,,https://pharos.nih.gov/idg/targets/O75469,,,,,,,,,,,,,NR1I2,,,O75469,,,,,,,,Nuclear receptor subfamily 1 group i member 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2089,"[""constipation""]",,A bowel dysfunction that is characterized by infrequent or difficult evacuation of feces.,false,,,http://purl.obolibrary.org/obo/DOID_9779,,,,,,,,A bowel dysfunction that is characterized by infrequent or difficult evacuation of feces.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2089,,,,ICD10CM:K59.00|UMLS_CUI:C0009806|SNOMEDCT_US_2016_03_01:162080004|SNOMEDCT_US_2016_03_01:139359007|SNOMEDCT_US_2016_03_01:139356000|SNOMEDCT_US_2016_03_01:363693003|NCI:C37930|SNOMEDCT_US_2016_03_01:162083002|SNOMEDCT_US_2016_03_01:14760008|ICD9CM:564.0|SNOMEDCT_US_2016_03_01:162082007|SNOMEDCT_US_2016_03_01:139358004|ICD10CM:K59.0|SNOMEDCT_US_2016_03_01:197123003|MESH:D003248|ICD9CM:564.00,,,disease_ontology,,DOID:2089,,,,,,,,,,,,,,,,,,,constipation,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300044,"[""GPR137 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300044,,,,,,,,,,,,,,,,,,,,,,,,,,,,GPR137 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3829,"[""pituitary adenoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060089|http://purl.obolibrary.org/obo/DOID_53|http://purl.obolibrary.org/obo/DOID_657,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3829,,,,SNOMEDCT_US_2016_03_01:154621002|SNOMEDCT_US_2016_03_01:269643009|UMLS_CUI:C0032000|MESH:D010911|SNOMEDCT_US_2016_03_01:254956000|SNOMEDCT_US_2016_03_01:189178001|SNOMEDCT_US_2016_03_01:128664001|SNOMEDCT_US_2016_03_01:367095008|NCI:C3329,adenoma of the Pituitary gland,,disease_ontology,,DOID:3829,,,,,,,,,,,,,,,,,,,pituitary adenoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200279,"[""NPFFR2 gene""]",,"A neuropeptide FF receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5X5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400069,,,,,,,,"A neuropeptide FF receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5X5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200279,,,,,,,,,,,,,,,,10886,NPFFR2,GPR74|NPFF2|NPGPR,,,,,,,,,,NPFFR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1923,"[""sex differentiation disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2277,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1923,,,,MESH:D012734|UMLS_CUI:C0036875,sex differentiation disorder|disorder of sexual differentiation (disorder),,disease_ontology,,DOID:1923,,,,,,,,,,,,,,,,,,,sex differentiation disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100020,"[""I315 in ABL1(T315I)-phosphorylated""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100020,,,,,,,,,,,,,,,,,,,,,,,,,,,,I315 in ABL1(T315I)-phosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200243,"[""LPAR6 gene""]",,"An oleoyl-L-alpha-lysophosphatidic acid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43657] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402007,,,,,,,,"An oleoyl-L-alpha-lysophosphatidic acid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43657] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200243,,,,,,,,,,,,,,,,10161,LPAR6,P2RY5,,,,,,,,,,LPAR6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100214,"[""Calcium/calmodulin-dependent protein kinase type 1""]",,"calcium/calmodulin-dependent protein kinase type 1 (CAMK1)  with  no mutation  in a nonphosphorylated state|A calcium/calmodulin-dependent protein kinase type 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14012] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300171,,,,,,,,"calcium/calmodulin-dependent protein kinase type 1 (CAMK1)  with  no mutation  in a nonphosphorylated state|A calcium/calmodulin-dependent protein kinase type 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14012] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100214,,,,https://pharos.nih.gov/idg/targets/Q14012,,,,,,,,,,,,,CAMK1,,,Q14012,,,,,,,,Calcium/calmodulin-dependent protein kinase type 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002914,"[""SK-N-MC cell""]",,"Human neuroblastoma cell line; established from the supraorbital metastasis of a neuroblastoma of a 14-year-old girl in 1971; although described in the original paper as neuroblastoma, SK-N-MC is now widely regarded as having originated from the morphologically similar Askin's tumor related to Ewing's sarcoma.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000932|http://purl.obolibrary.org/obo/BTO_0002912,,,,,,,,"Human neuroblastoma cell line; established from the supraorbital metastasis of a neuroblastoma of a 14-year-old girl in 1971; although described in the original paper as neuroblastoma, SK-N-MC is now widely regarded as having originated from the morphologically similar Askin's tumor related to Ewing's sarcoma.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002914,,,,,,,BrendaTissueOBO,,BTO:0002914,,,,,,,,,,,,,,,,,,,SK-N-MC cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200047,"[""C5AR2 gene""]",,"A C5a anaphylatoxin chemotactic receptor C5L2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9P296] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400027,,,,,,,,"A C5a anaphylatoxin chemotactic receptor C5L2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9P296] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200047,,,,,,,,,,,,,,,,27202,C5AR2,C5L2|GPR77,,,,,,,,,,C5AR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200080,"[""CLIC2 gene""]",,"This gene encodes a chloride intracellular channel protein. Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. This protein may play a role in inhibiting the function of ryanodine receptor 2. A mutation in this gene is the cause of X-linked mental retardation-32. [provided by RefSeq, Aug 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_01400342,,,,,,,,"This gene encodes a chloride intracellular channel protein. Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. This protein may play a role in inhibiting the function of ryanodine receptor 2. A mutation in this gene is the cause of X-linked mental retardation-32. [provided by RefSeq, Aug 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200080,,,,,,,,,,,,,,,,1193,CLIC2,,,,,,,,,,,CLIC2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300183,"[""LMR family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300183,,,,,,,,,,,,,,,,,,,,,,,,,,,,LMR family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2174,"[""ocular cancer""]",,A sensory system cancer located_in the eye that is characterized by uncontrolled cellular proliferation in the eye.,false,,,http://purl.obolibrary.org/obo/DOID_0060116,,,,,,,,A sensory system cancer located_in the eye that is characterized by uncontrolled cellular proliferation in the eye.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2174,,,DOID:9985,NCI:C3030|MESH:D005134|SNOMEDCT_US_2016_03_01:371486001|SNOMEDCT_US_2016_03_01:126995000|UMLS_CUI:C0153632|UMLS_CUI:C0015414|ICD9CM:190.8|SNOMEDCT_US_2016_03_01:188277006,neoplasm of eye|Ocular tumor|neoplasm of eye proper|eye neoplasm|malignant eye neoplasm,,disease_ontology,,DOID:2174,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,ocular cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_7872,"[""oxytocin""]","1006.436|oxytocine|oxytocin|XNOPRXBHLZRZKH-DSZYJQQASA-N|1007.18982|Piton S|Pitocin|Orasthin|OT|Endopituitrina|(1-Hemicystine)oxytocin|OXT|C43H66N12O12S2|[H][C@]1(NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)[C@@H](C)CC|Syntocinon|3-Isoleucine-8-leucine vasopressin|oxytocinum|L-Cysteinyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-leucylglycinamide cyclic(1-6)-disulfide|Ocytocin|InChI=1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1|0|oxitocina","A cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG that also acts as a neurotransmitter in the brain; the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary. Together with the neuropeptide vasopressin, it is believed to influence social cognition and behaviour.",false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,Patent:US2938891|PMID:19482229|PMID:11134819|Drug_Central:2042|PMID:19104313|PMID:19369205|PMID:25209411|Beilstein:3586108|PMID:18988842|HMDB:HMDB02865|CAS:50-56-6|DrugBank:DB00107|PMID:24706799|PMID:18593851|PMID:15815422|KEGG:C00746|KEGG:D00089|PMID:13305558|Wikipedia:Oxytocin|Patent:US3076797,"A cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG that also acts as a neurotransmitter in the brain; the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary. Together with the neuropeptide vasopressin, it is believed to influence social cognition and behaviour.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,"1-({(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-(4-hydroxybenzyl)-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-prolyl-L-leucylglycinamide|Oxytocin",,chebi_ontology,"1006.436|oxytocine|oxytocin|XNOPRXBHLZRZKH-DSZYJQQASA-N|1007.18982|Piton S|Pitocin|Orasthin|OT|Endopituitrina|(1-Hemicystine)oxytocin|OXT|C43H66N12O12S2|[H][C@]1(NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)[C@@H](C)CC|Syntocinon|3-Isoleucine-8-leucine vasopressin|oxytocinum|L-Cysteinyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-leucylglycinamide cyclic(1-6)-disulfide|Ocytocin|InChI=1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1|0|oxitocina",,,CHEBI:7872,,,,,,,,,,,,,,,,,,,,,,,CHEBI:7872,,,,,oxytocin,,CHEBI:7872,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200095,"[""CATSPER3 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400345,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200095,,,,,,,,,,,,,,,,347732,CATSPER3,,,,,,,,,,,CATSPER3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100155,"[""Probable g-protein coupled receptor 152""]",,"A G-protein coupled receptor 152 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDT2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300052,,,,,,,,"A G-protein coupled receptor 152 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDT2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100155,,,,https://pharos.nih.gov/idg/targets/Q8TDT2,,,,,,,,,,,,,GPR152,PGR5,,Q8TDT2,,,,,,,,Probable g-protein coupled receptor 152,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001893,"[""ring stage""]",,"The early trophozoite in the erythrocytic stage of the life cycle of hemosporian protozoa, which after Romanovsky staining has blue cytoplasm surrounding a clear zone with a red nucleus at one side, giving the cell the appearance of a signet ring.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001397,,,,,,,,"The early trophozoite in the erythrocytic stage of the life cycle of hemosporian protozoa, which after Romanovsky staining has blue cytoplasm surrounding a clear zone with a red nucleus at one side, giving the cell the appearance of a signet ring.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001893,,,,,,,BrendaTissueOBO,signet ring|ring form,BTO:0001893,,,,,,,,,,,,,,,,,,,ring stage,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200183,"[""IKBKE gene""]",,"IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400164,,,,,,,,"IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200183,,,,,,,,,,,,,,,,9641,IKBKE,IKKE|IKKI|KIAA0151,,,,,,,,,,IKBKE gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000144,"[""MET192 in STK33""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000144,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET192 in STK33,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1176,"[""bronchial disease""]",,"A lower respiratory tract disease that affects the airways leading into the lungs, which is caused due to inflammation of the bronchi and bronchioles, infection, or blockage.",false,,,http://purl.obolibrary.org/obo/DOID_0050161,,,,,,,,"A lower respiratory tract disease that affects the airways leading into the lungs, which is caused due to inflammation of the bronchi and bronchioles, infection, or blockage.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1176,,,DOID:12322|DOID:1175,UMLS_CUI:C0006261|SNOMEDCT_US_2016_03_01:41427001|MESH:D001982,Bronchospasm,,disease_ontology,,DOID:1176,,,,,,,,,,,,,,,,,,,bronchial disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004046,"[""alveolar mucosa""]",,The mucous membrane apical to the attached gingiva.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The mucous membrane apical to the attached gingiva.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004046,,,,,,,BrendaTissueOBO,,BTO:0004046,,,,,,,,,,,,,,,,,,,alveolar mucosa,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200403,"[""PDGFRA gene""]",,"This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400141,,,,,,,,"This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200403,,,,,,,,,,,,,,,,5156,PDGFRA,PDGFR2|RHEPDGFRA,,,,,,,,,,PDGFRA gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200263,"[""NOX5 gene""]",,"This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes a calcium-dependen NADPH oxidase that generates superoxide, and functions as a calcium-dependent proton channel that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400346,,,,,,,,"This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes a calcium-dependen NADPH oxidase that generates superoxide, and functions as a calcium-dependent proton channel that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200263,,,,,,,,,,,,,,,,79400,NOX5,,,,,,,,,,,NOX5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100137,"[""Glutamate receptor ionotropic, delta-1""]",,"A glutamate receptor ionotropic, delta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9ULK0] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300414,,,,,,,,"A glutamate receptor ionotropic, delta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9ULK0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100137,,,,https://pharos.nih.gov/idg/targets/Q9ULK0,,,,,,,,,,,,,GRID1,KIAA1220,,Q9ULK0,,,,,,,,"Glutamate receptor ionotropic, delta-1",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000032,"[""colonic adenocarcinoma cell""]",,"A cell of an adenocarcinoma of the colon is a malignant neoplastic epithelial lesion, arising from the colonic mucosa.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000035,,,,,,,,"A cell of an adenocarcinoma of the colon is a malignant neoplastic epithelial lesion, arising from the colonic mucosa.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000032,,,,,,,BrendaTissueOBO,"adenocarcinoma cell, colon|colon adenocarcinoma cell",BTO:0000032,,,,,,,,,,,,,,,,,,,colonic adenocarcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200315,"[""MAPK1 gene""]",,"This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400292,,,,,,,,"This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200315,,,,,,,,,,,,,,,,5594,MAPK1,ERK2|PRKM1|PRKM2,,,,,,,,,,MAPK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13564,"[""aspergillosis""]",,"An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus Aspergillus infecting lungs, brain, kidney,heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system.",false,,,http://purl.obolibrary.org/obo/DOID_2473,,,,,,,,"An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus Aspergillus infecting lungs, brain, kidney,heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13564,,,,SNOMEDCT_US_2016_03_01:187492008|MESH:D001228|SNOMEDCT_US_2016_03_01:154408001|ICD9CM:117.3|CSP:1988-4002|SNOMEDCT_US_2016_03_01:65553006|ICD10CM:B44.9|ICD10CM:B44|NCI:C2886|UMLS_CUI:C0004030|SNOMEDCT_US_2016_03_01:266218008|SNOMEDCT_US_2016_03_01:187087004,Infection due to Aspergillus,,disease_ontology,,DOID:13564,,,,,,,,,,,,,,,,,,,aspergillosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11132,"[""prostatic hypertrophy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_47,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11132,,,,,,,disease_ontology,,DOID:11132,,,,,,,,,,,,,,,,,,,prostatic hypertrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11130,"[""secondary hypertension""]",,,false,,,http://purl.obolibrary.org/obo/DOID_10763,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11130,,,,ICD10CM:I15.9|NCI:C3657|ICD9CM:405|SNOMEDCT_US_2016_03_01:194789002|SNOMEDCT_US_2016_03_01:155300002|SNOMEDCT_US_2016_03_01:194792003|ICD10CM:I15|UMLS_CUI:C0155616|ICD9CM:405.9|SNOMEDCT_US_2016_03_01:31992008,,,disease_ontology,,DOID:11130,,,,,,,,,,,,,,,,,,,secondary hypertension,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2621,"[""autonomic nervous system neoplasm""]",,A peripheral nervous system neoplasm that is located_in the autonomic nervous system.,false,,,http://purl.obolibrary.org/obo/DOID_1192,,,,,,,,A peripheral nervous system neoplasm that is located_in the autonomic nervous system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2621,,,,UMLS_CUI:C1332356|NCI:C5112,tumor of Autonomic nervous system,,disease_ontology,,DOID:2621,,,,,,,,,,,,,,,,,,,autonomic nervous system neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100645,"[""Olfactory receptor 5T1""]",,"An olfactory receptor 5T1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG75] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5T1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG75] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100645,,,,https://pharos.nih.gov/idg/targets/Q8NG75,,,,,,,,,,,,,OR5T1,OR5T1P,,Q8NG75,,,,,,,,Olfactory receptor 5T1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1192,"[""peripheral nervous system neoplasm""]",,A nervous system cancer that is located_in the peripheral nervous system.,false,,,http://purl.obolibrary.org/obo/DOID_3093,,,,,,,,A nervous system cancer that is located_in the peripheral nervous system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1192,,,DOID:3194,SNOMEDCT_US_2016_03_01:115242003|SNOMEDCT_US_2016_03_01:134214003|SNOMEDCT_US_2016_03_01:126980002|UMLS_CUI:C0206727|UMLS_CUI:C0031118|MESH:D018317|NCI:C4972|MESH:D010524|SNOMEDCT_US_2016_03_01:189946005|SNOMEDCT_US_2016_03_01:189953001|NCI:C3321,neoplasm of peripheral nerve (disorder)|nerve sheath neoplasm|nerve sheath tumors|tumor of PNS,,disease_ontology,,DOID:1192,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,peripheral nervous system neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002119,"[""spikelet""]",,"A small or secondary spike, specifically one of the small few-flowered bracted spikes that make up the compound inflorescence of a grass or sedge.",false,,,http://purl.obolibrary.org/obo/BTO_0001278|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A small or secondary spike, specifically one of the small few-flowered bracted spikes that make up the compound inflorescence of a grass or sedge.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002119,,,,,,,BrendaTissueOBO,,BTO:0002119,,,,,,,,,,,,,,,,,,,spikelet,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000017,"[""Chemerin""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000017,,,,,,,,,,,,,,,,,,,,,,,,,,,,Chemerin,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003467,"[""HS-294T cell""]",,Human melanoma cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0000849|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human melanoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003467,,,,,,,BrendaTissueOBO,Hs294 cell|Hs294T cell|Hs 294T cell|HS-294 cell,BTO:0003467,,,,,,,,,,,,,,,,,,,HS-294T cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200143,"[""GRIK5 gene""]",,"This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_01400420,,,,,,,,"This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200143,,,,,,,,,,,,,,,,2901,GRIK5,GRIK2,,,,,,,,,,GRIK5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491047,"[""PFKFB1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400325,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491047,,,,,,,,,,,,,,,,,PFKFB1,,,,,,,,,,,PFKFB1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300363,"[""Cation-nonselective channel family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300363,,,,,,,,,,,,,,,,,,,,,,,,,,,,Cation-nonselective channel family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400284,"[""MLK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400165,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400284,,,,,,,,,,,,,,,,,,,,,,,,,,,,MLK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1838,"[""Menkes disease""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_421|http://purl.obolibrary.org/obo/DOID_896,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1838,,,,NCI:C75486|UMLS_CUI:C0022716|OMIM:309400|MESH:D007706|SNOMEDCT_US_2016_03_01:59178007,steely hair syndrome|COPPER TRANSPORT DISEASE|Menkes kinky-hair syndrome,,disease_ontology,,DOID:1838,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Menkes disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100207,"[""Casein kinase i isoform alpha-like""]",,"A casein kinase I isoform alpha-like that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N752] |casein kinase i isoform alpha-like (CSNK1A1L)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300170,,,,,,,,"A casein kinase I isoform alpha-like that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N752] |casein kinase i isoform alpha-like (CSNK1A1L)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100207,,,,https://pharos.nih.gov/idg/targets/Q8N752,,,,,,,,,,,,,CSNK1A1L,,,Q8N752,,,,,,,,Casein kinase i isoform alpha-like,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200371,"[""NTRK1 gene""]",,"This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400200,,,,,,,,"This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200371,,,,,,,,,,,,,,,,4914,NTRK1,MTC|TRK|TRKA,,,,,,,,,,NTRK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5389,"[""oxyphilic adenoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060089,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5389,,,,MESH:D018249|UMLS_CUI:C1510502|SNOMEDCT_US_2016_03_01:89439007|NCI:C3759,"Oncocytoma|Follicular adenoma, oxyphilic cell",,disease_ontology,,DOID:5389,,,,,,,,,,,,,,,,,,,oxyphilic adenoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200160,"[""GPR160 gene""]",,"A G-protein coupled receptor 160 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UJ42] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400052,,,,,,,,"A G-protein coupled receptor 160 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UJ42] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200160,,,,,,,,,,,,,,,,26996,GPR160,GPCR150,,,,,,,,,,GPR160 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200173,"[""GPRC5C gene""]",,"A G-protein coupled receptor family C group 5 member C that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NQ84] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400004,,,,,,,,"A G-protein coupled receptor family C group 5 member C that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NQ84] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200173,,,,,,,,,,,,,,,,55890,GPRC5C,RAIG3,,,,,,,,,,GPRC5C gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1969,"[""cerebral palsy""]",,"A brain disease that is caused by damage to the motor control centers of the developing brain during pregnancy, during childbirth or after birth, which affects muscle movement and balance.",false,,,http://purl.obolibrary.org/obo/DOID_936,,,,,,,,"A brain disease that is caused by damage to the motor control centers of the developing brain during pregnancy, during childbirth or after birth, which affects muscle movement and balance.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1969,,,DOID:1968,CSP:0723-4729|SNOMEDCT_US_2016_03_01:155024003|ICD10CM:G80.9|ICD9CM:343.8|UMLS_CUI:C0029806|UMLS_CUI:C0007789|NCI:C34460|MESH:D002547|SNOMEDCT_US_2016_03_01:267696006|ICD10CM:G80|SNOMEDCT_US_2016_03_01:128188000|SNOMEDCT_US_2016_03_01:1178005|SNOMEDCT_US_2016_03_01:270488006,infantile cerebral palsy,,disease_ontology,,DOID:1969,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,cerebral palsy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100112,"[""Integral membrane protein GPR137""]",,"An integral membrane protein GPR137 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96N19] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300044,,,,,,,,"An integral membrane protein GPR137 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96N19] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100112,,,,https://pharos.nih.gov/idg/targets/Q96N19,,,,,,,,,,,,,GPR137,C11orf4|GPR137A|TM7SF1L1,,Q96N19,,,,,,,,Integral membrane protein GPR137,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005514,"[""gonadal sheath cell""]",,"In Caenorhabditis elegans, specialized contractile myoepithelial cells of the somatic gonad, the gonadal sheath cells, are closely apposed to oocytes and are required for normal meiotic maturation and ovulation.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002309,,,,,,,,"In Caenorhabditis elegans, specialized contractile myoepithelial cells of the somatic gonad, the gonadal sheath cells, are closely apposed to oocytes and are required for normal meiotic maturation and ovulation.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005514,Marion,2013-10-16T12:51:49Z,,,,,BrendaTissueOBO,,BTO:0005514,,,,,,,,,,,,,,,,,,,gonadal sheath cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200284,"[""NPY5R gene""]",,"A neuropeptide Y receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15761] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400071,,,,,,,,"A neuropeptide Y receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15761] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200284,,,,,,,,,,,,,,,,4889,NPY5R,NPYR5,,,,,,,,,,NPY5R gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117524,"[""Nuclear receptor subfamily 5 group a member 2""]",,"A nuclear receptor subfamily 5 group A member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00482] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117476,,,,,,,,"A nuclear receptor subfamily 5 group A member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00482] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117524,,,,https://pharos.nih.gov/idg/targets/O00482,,,,,,,,,,,,,NR5A2,CPF,,O00482,,,,,,,,Nuclear receptor subfamily 5 group a member 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100077,"[""Cyclin-dependent kinase-like 2""]",,"cyclin-dependent kinase-like 2 (CDKL2)  with  no mutation  in a nonphosphorylated state|A cyclin-dependent kinase-like 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92772] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300138,,,,,,,,"cyclin-dependent kinase-like 2 (CDKL2)  with  no mutation  in a nonphosphorylated state|A cyclin-dependent kinase-like 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92772] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100077,,,,https://pharos.nih.gov/idg/targets/Q92772,,,,,,,,,,,,,CDKL2,,,Q92772,,,,,,,,Cyclin-dependent kinase-like 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002584,"[""WRL-68 cell""]",,Hela cells containing human papilloma viral (HPV) DNA sequences.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Hela cells containing human papilloma viral (HPV) DNA sequences.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002584,,,,,,,BrendaTissueOBO,WRL68 cell|WRL 68 cell,BTO:0002584,,,,,,,,,,,,,,,,,,,WRL-68 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200168,"[""GPR182 gene""]",,"A G-protein coupled receptor 182 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O15218] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400054,,,,,,,,"A G-protein coupled receptor 182 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O15218] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200168,,,,,,,,,,,,,,,,11318,GPR182,ADMR,,,,,,,,,,GPR182 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001709,"[""colonic epithelium""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000781,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001709,,,,,,,BrendaTissueOBO,colon epithelium,BTO:0001709,,,,,,,,,,,,,,,,,,,colonic epithelium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3312,"[""bipolar disorder""]",,A mood disorder that involves alternating periods of mania and depression.,false,,,http://purl.obolibrary.org/obo/DOID_3324,,,,,,,,A mood disorder that involves alternating periods of mania and depression.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3312,,,DOID:3311|DOID:9554|DOID:9555,SNOMEDCT_US_2016_03_01:191654006|SNOMEDCT_US_2016_03_01:191627008|SNOMEDCT_US_2016_03_01:154871001|NCI:C34424|SNOMEDCT_US_2016_03_01:16506000|ICD10CM:F31.9|UMLS_CUI:C0005587|ICD9CM:296.60|NCI:C34805|NCI:C34423|SNOMEDCT_US_2016_03_01:191647000|ICD9CM:296.80|SNOMEDCT_US_2016_03_01:268749008|EFO:0000289|UMLS_CUI:C0024713|SNOMEDCT_US_2016_03_01:191646009|MESH:D001714|SNOMEDCT_US_2016_03_01:192355004|SNOMEDCT_US_2016_03_01:68569003|SNOMEDCT_US_2016_03_01:13746004|ICD9CM:296.40|UMLS_CUI:C0005586|UMLS_CUI:C0236780|SNOMEDCT_US_2016_03_01:192365005|ICD10CM:F31,Manic bipolar I disorder|Manic Depressive disorder|manic depression|mixed bipolar disorder|Manic Bipolar Affective disorder|bipolar depression|bipolar disorder manic phase|manic disorder,,disease_ontology,Depressive-manic psych.,DOID:3312,,,,,,,,,,,,,,,,,,,bipolar disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300145,"[""DMPK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300145,,,,,,,,,,,,,,,,,,,,,,,,,,,,DMPK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1866,"[""giant cell reparative granuloma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4305,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1866,,,,UMLS_CUI:C0162375|MESH:D006101|ICD10CM:M27.1|ICD9CM:526.3|SNOMEDCT_US_2016_03_01:15350006,central giant cell reparative granuloma of jaw (disorder)|central giant cell granuloma|central giant cell (reparative) granuloma,,disease_ontology,,DOID:1866,,,,,,,,,,,,,,,,,,,giant cell reparative granuloma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000385,"[""THR699 in EPHA4""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000385,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR699 in EPHA4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_16189,"[""Sulfate""]","[O-]S([O-])(=O)=O|Sulfate (ion 2-)|Sulfate anion|Sulfate ion (SO42-)|Sulfate dianion|Sulfate ion|SULFATE ION|[SO4](2-)|SO4(2-)|O4S|sulphate|InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2|Sulfuric acid ion(2-)|Sulfate(2-)|Sulfate anion(2-)|QAOWNCQODCNURD-UHFFFAOYSA-L|sulphate ion","
A sulfur oxoanion obtained by deprotonation of both OH groups of sulfuric acid.
",false,,,http://purl.obolibrary.org/obo/CHEBI_22563,,,,,,,CiteXplore:11114076|CiteXplore:9449976|CiteXplore:8201096|CiteXplore:19244483|CiteXplore:19544990|Beilstein:3648446|Wikipedia:Sulfate|CiteXplore:9422978|CiteXplore:17714467|CiteXplore:11581495|CiteXplore:12653630|CiteXplore:16709187|CiteXplore:19628332|CiteXplore:17709180|CiteXplore:9251237|KEGG COMPOUND:C00059|CiteXplore:16709182|NIST Chemistry WebBook:14808-79-8|CiteXplore:15715602|CiteXplore:14597181|Gmelin:2120|CiteXplore:10917625|CiteXplore:14690476|CiteXplore:16406662|CiteXplore:16072037|CiteXplore:16709181|CiteXplore:16709188|CiteXplore:18815700|CiteXplore:11279786|CiteXplore:16742508|CiteXplore:16709175|CiteXplore:7823020|CiteXplore:18846414|CiteXplore:17460664|CiteXplore:11235060|CiteXplore:11599227|CiteXplore:17515291|CiteXplore:11200094|CiteXplore:16917509|CiteXplore:10959410|CiteXplore:12653636|KEGG DRUG:D05963|CiteXplore:1939488|CiteXplore:1516727|CiteXplore:17420092|CiteXplore:14583911|CiteXplore:8943798|CiteXplore:18398178|CiteXplore:7829123|CiteXplore:2094230|CiteXplore:15093386|CiteXplore:10796145|CiteXplore:17692016|CiteXplore:15984785|CiteXplore:12653633|CiteXplore:17439666|CiteXplore:11798107|CiteXplore:19047345|CiteXplore:11452993|CiteXplore:12519550|CiteXplore:12653631|CiteXplore:16656509|CiteXplore:15749066|CiteXplore:14583910|MetaCyc:NH42SO4|CiteXplore:15613519|CiteXplore:16742518|CiteXplore:16347366|CiteXplore:12166931|CiteXplore:24246267|CiteXplore:16026302|CiteXplore:8878010|CiteXplore:13679662|CiteXplore:10561778|CiteXplore:1472758|PDBeChem:SO4|CiteXplore:17120760|Reaxys:3648446|CiteXplore:16475944|CiteXplore:9573551|CiteXplore:12420348|CiteXplore:16483812|CiteXplore:16534979|CiteXplore:17168807|CiteXplore:14609305|CiteXplore:10783877|CiteXplore:9172804|CiteXplore:10386253|CiteXplore:15152354|ChemIDplus:14808-79-8|CiteXplore:16709184|CiteXplore:16709185|CiteXplore:12668033|CiteXplore:12440375|CiteXplore:16348007|CiteXplore:16345535|CiteXplore:8805242|MetaCyc:SULFATE|CiteXplore:8038262|CiteXplore:12915942|CiteXplore:12735485|CiteXplore:12878436|CiteXplore:12804383|CiteXplore:19812358|HMDB:HMDB01448|CiteXplore:17636771|CiteXplore:10796146|CiteXplore:16186560,"
A sulfur oxoanion obtained by deprotonation of both OH groups of sulfuric acid.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:45687|CHEBI:9335|CHEBI:15135,,Sulfate|sulfate|tetraoxosulfate(VI)|tetraoxidosulfate(2-)|tetraoxosulfate(2-),,chebi_ontology,"[O-]S([O-])(=O)=O|Sulfate (ion 2-)|Sulfate anion|Sulfate ion (SO42-)|Sulfate dianion|Sulfate ion|SULFATE ION|[SO4](2-)|SO4(2-)|O4S|sulphate|InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2|Sulfuric acid ion(2-)|Sulfate(2-)|Sulfate anion(2-)|QAOWNCQODCNURD-UHFFFAOYSA-L|sulphate ion",,,CHEBI:16189,,,,,,,,,,,,,,,,,,,,,,,CHEBI:16189,,,,,Sulfate|sulfate,,CHEBI:16189,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300122,"[""ALK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300122,,,,,,,,,,,,,,,,,,,,,,,,,,,,ALK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200034,"[""CACNA2D1 gene""]",,"The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_01400332,,,,,,,,"The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200034,,,,,,,,,,,,,,,,781,CACNA2D1,CACNL2A|CCHL2A|MHS3,,,,,,,,,,CACNA2D1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100693,"[""Olfactory receptor 8D4""]",,"An olfactory receptor 8D4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGM9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 8D4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGM9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100693,,,,https://pharos.nih.gov/idg/targets/Q8NGM9,,,,,,,,,,,,,OR8D4,,,Q8NGM9,,,,,,,,Olfactory receptor 8D4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000061,"[""LEU159 in PLK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000061,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU159 in PLK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400429,"[""KCNJ2 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400429,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ2 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1159,"[""functional gastric disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_76,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1159,,,,UMLS_CUI:C0013396|ICD9CM:536.8,,,disease_ontology,,DOID:1159,,,,,,,,,,,,,,,,,,,functional gastric disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100525,"[""Olfactory receptor 2g3""]",,"An olfactory receptor 2G3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2G3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100525,,,,https://pharos.nih.gov/idg/targets/Q8NGZ4,,,,,,,,,,,,,OR2G3,,,Q8NGZ4,,,,,,,,Olfactory receptor 2g3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400338,"[""ABCC family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400338,,,,,,,,,,,,,,,,,,,,,,,,,,,,ABCC family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100163,"[""Probable g-protein coupled receptor 171""]",,"A G-protein coupled receptor 171 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14626] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300053,,,,,,,,"A G-protein coupled receptor 171 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14626] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100163,,,,https://pharos.nih.gov/idg/targets/O14626,,,,,,,,,,,,,GPR171,H963,,O14626,,,,,,,,Probable g-protein coupled receptor 171,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000041,"[""medulla oblongata""]",,The part of the vertebrate brain that is continuous posteriorly with the spinal cord and that contains the centers controlling involuntary vital functions.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The part of the vertebrate brain that is continuous posteriorly with the spinal cord and that contains the centers controlling involuntary vital functions.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000041,,,,,,,BrendaTissueOBO,metepencephalon,BTO:0000041,,,,,,,,,,,,,,,,,,,medulla oblongata,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001033,"[""prostate cancer cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001019,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001033,,,,,,,BrendaTissueOBO,CaP cell|prostate carcinoma cell line|prostate tumor cell line|PCa cell line|PCa cell|prostate gland cancer cell line|CaP cell line,BTO:0001033,,,,,,,,,,,,,,,,,,,prostate cancer cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200100,"[""DAPK3 gene""]",,"Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells.  These results suggest that DAPK3 may play a role in the induction of apoptosis. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400146,,,,,,,,"Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells.  These results suggest that DAPK3 may play a role in the induction of apoptosis. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200100,,,,,,,,,,,,,,,,1613,DAPK3,ZIPK,,,,,,,,,,DAPK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02390001,"[""Aminergic GPCR""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300001,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02390001,,,,,,,,,,,,,,,,,,,,,,,,,,,,Aminergic GPCR,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200687,"[""OR8B3 gene""]",,"An olfactory receptor 8B3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 8B3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200687,,,,,,,,,,,,,,,,390271,OR8B3,,,,,,,,,,,OR8B3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400557,"[""Kv10.2/KCNH5 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400448,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400557,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv10.2/KCNH5 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100404,"[""Olfactory receptor 51Q1""]",,"An olfactory receptor 51Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH59] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 51Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH59] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100404,,,,https://pharos.nih.gov/idg/targets/Q8NH59,,,,,,,,,,,,,OR51Q1,,,Q8NH59,,,,,,,,Olfactory receptor 51Q1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13774,"[""Addison's disease""]",,An adrenal cortical hypofunction that is characterized by insufficient steroid hormone production by the adrenal glands.,false,,,http://purl.obolibrary.org/obo/DOID_10493,,,,,,,,An adrenal cortical hypofunction that is characterized by insufficient steroid hormone production by the adrenal glands.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13774,,,,SNOMEDCT_US_2016_03_01:68588005|MESH:D000224|SNOMEDCT_US_2016_03_01:373662000|OMIM:103230|ICD10CM:E27.1|SNOMEDCT_US_2016_03_01:154707007|UMLS_CUI:C0001403|SNOMEDCT_US_2016_03_01:111562000|SNOMEDCT_US_2016_03_01:267483004|SNOMEDCT_US_2016_03_01:363732003|OMIM:240200|SNOMEDCT_US_2016_03_01:367376006|NCI:C26689,"Addison disease, chronic adrenal insufficiency|HYPOADRENOCORTICISM, FAMILIAL|primary hypoadrenalism|primary adrenocortical insufficiency|Addison disease",,disease_ontology,,DOID:13774,,,,,,,,,,,,,,,,,,,Addison's disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13777,"[""epidermodysplasia verruciformis""]",,"An autosomal recessive disease that results_in skin squamous cell carcinoma located_in skin, associated with a high risk of carcinoma. It is characterized by abnormal susceptibility to human papillomaviruses of the skin and has_symptom lesions on the body.",false,,,http://purl.obolibrary.org/obo/DOID_0050737,,,,,,,,"An autosomal recessive disease that results_in skin squamous cell carcinoma located_in skin, associated with a high risk of carcinoma. It is characterized by abnormal susceptibility to human papillomaviruses of the skin and has_symptom lesions on the body.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13777,,,,SNOMEDCT_US_2016_03_01:19138001|MESH:D004819|OMIM:226400|UMLS_CUI:C0014522,,,disease_ontology,,DOID:13777,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,epidermodysplasia verruciformis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000318,"[""NEK9 kinase domain""]",,NIMA (never in mitosis gene a)-related kinase 9; DKFZp434D0935; MGC138306; MGC16714; Nek8; NEK9; NERCC; NERCC1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,NIMA (never in mitosis gene a)-related kinase 9; DKFZp434D0935; MGC138306; MGC16714; Nek8; NEK9; NERCC; NERCC1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000318,,,,,,,,,,,,,,,,,,,200294,,,,,,,,,NEK9 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300465,"[""Nav1.2/SCN2A subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300369,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300465,,,,,,,,,,,,,,,,,,,,,,,,,,,,Nav1.2/SCN2A subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_93,"[""language disorder""]",,A communication disorder that involves the processing of linguistic information.,false,,,http://purl.obolibrary.org/obo/DOID_2033,,,,,,,,A communication disorder that involves the processing of linguistic information.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:93,,,,MESH:D007806|UMLS_CUI:C0023015|ICD10CM:F80.9|SNOMEDCT_US_2016_03_01:62305002|NCI:C97155,,,disease_ontology,,DOID:93,,,,,,,,,,,,,,,,,,,language disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_936,"[""brain disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_331,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:936,,,DOID:8510,SNOMEDCT_US_2016_03_01:155053002|SNOMEDCT_US_2016_03_01:81308009|ICD10CM:G93.9|MESH:D001927|SNOMEDCT_US_2016_03_01:193059005|ICD9CM:348.9|ICD9CM:348.30|ICD10CM:G93.40|SNOMEDCT_US_2016_03_01:193051008|ICD9CM:348.3|NCI:C26920|UMLS_CUI:C0085584|UMLS_CUI:C0006111|NCI:C96413|SNOMEDCT_US_2016_03_01:76011009,encephalopathy,,disease_ontology,,DOID:936,,,,,,,,,,,,,,,,,,,brain disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_930,"[""orbital disease""]",,An adnexa disease that is located_in the eye socket.,false,,,http://purl.obolibrary.org/obo/DOID_0050815,,,,,,,,An adnexa disease that is located_in the eye socket.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:930,,,,SNOMEDCT_US_2016_03_01:194036005|SNOMEDCT_US_2016_03_01:155200004|ICD10CM:H05.9|UMLS_CUI:C0029182|ICD9CM:376.9|SNOMEDCT_US_2016_03_01:267746003|ICD9CM:376|MESH:D009916|SNOMEDCT_US_2016_03_01:11270005|ICD10CM:H05,,,disease_ontology,,DOID:930,,,,,,,,,,,,,,,,,,,orbital disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_934,"[""viral infectious disease""]",,"A disease by infectious agent that results_in infection, has_material_basis_in Viruses.",false,,,http://purl.obolibrary.org/obo/DOID_0050117,,,,,,,,"A disease by infectious agent that results_in infection, has_material_basis_in Viruses.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:934,,,DOID:1329,UMLS_CUI:C0042769|SNOMEDCT_US_2016_03_01:154319002|MESH:D001102|SNOMEDCT_US_2016_03_01:187471008|SNOMEDCT_US_2016_03_01:34014006|NCI:C34396|UMLS_CUI:C0003723|ICD10CM:B34|SNOMEDCT_US_2016_03_01:186619002|ICD9CM:066.9|SNOMEDCT_US_2016_03_01:266188005|ICD10CM:A94|NCI:C3439|SNOMEDCT_US_2016_03_01:40610006|SNOMEDCT_US_2016_03_01:186754003|SNOMEDCT_US_2016_03_01:266116004|SNOMEDCT_US_2016_03_01:266194002|SNOMEDCT_US_2016_03_01:154345006|MESH:D014777|ICD10CM:B34.9|SNOMEDCT_US_2016_03_01:154372003|ICD9CM:060-066.99,virus infection|Viral Infection|Viral disease,,disease_ontology,,DOID:934,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,viral infectious disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1811,"[""reflex sympathetic dystrophy""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_3223,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1811,,,,SNOMEDCT_US_2016_03_01:192921009|SNOMEDCT_US_2016_03_01:393605009|SNOMEDCT_US_2016_03_01:128079007|ICD9CM:337.20|SNOMEDCT_US_2016_03_01:15743005|ICD10CM:G90.5|ICD10CM:M89.0|SNOMEDCT_US_2016_03_01:2103002|SNOMEDCT_US_2016_03_01:156849009|UMLS_CUI:C0034931|ICD9CM:337.2|NCI:C85042|MESH:D012019|SNOMEDCT_US_2016_03_01:403604006|SNOMEDCT_US_2016_03_01:50642008|ICD9CM:337.21|SNOMEDCT_US_2016_03_01:203490000|OMIM:604335|SNOMEDCT_US_2016_03_01:203492008,,,disease_ontology,,DOID:1811,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,reflex sympathetic dystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000404,"[""THR790 in EGFR(S752-I759del)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000404,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR790 in EGFR(S752-I759del),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002315,"[""supporting cell""]",,"Cells that serve to provide support and protection and perhaps contribute to the nutrition of principal or other cells of certain organs; such cells are found in the labyrinth of the inner ear, organ of Corti, olfactory epithelium, taste buds, and seminiferous tubules (Sertoli's cells).",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002322,,,,,,,,"Cells that serve to provide support and protection and perhaps contribute to the nutrition of principal or other cells of certain organs; such cells are found in the labyrinth of the inner ear, organ of Corti, olfactory epithelium, taste buds, and seminiferous tubules (Sertoli's cells).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002315,,,,,,,BrendaTissueOBO,sustentacular cell,BTO:0002315,,,,,,,,,,,,,,,,,,,supporting cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_705,"[""Leber hereditary optic neuropathy""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_1891,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:705,,,,ICD10CM:H47.22|SNOMEDCT_US_2016_03_01:58610003|SNOMEDCT_US_2016_03_01:230510002|NCI:C84808|MESH:D029242|SNOMEDCT_US_2016_03_01:194045006|UMLS_CUI:C0917796|OMIM:535000,Leber's optic atrophy (disorder)|Leber's optic atrophy|Leber's hereditary optic neuropathy,,disease_ontology,,DOID:705,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Leber hereditary optic neuropathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_700,"[""mitochondrial metabolism disease""]",,An inherited metabolic disorder that involves mitochondrial metabolism dysfunction.,false,,,http://purl.obolibrary.org/obo/DOID_655,,,,,,,,An inherited metabolic disorder that involves mitochondrial metabolism dysfunction.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:700,,,,UMLS_CUI:C0751651|SNOMEDCT_US_2016_03_01:240096000|MESH:D028361,,,disease_ontology,,DOID:700,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,mitochondrial metabolism disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_706,"[""mature B-cell neoplasm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_707,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:706,,,,EFO:0000096|NCI:C27910|UMLS_CUI:C1334633,mature B-cell lymphocytic neoplasm,,disease_ontology,,DOID:706,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,mature B-cell neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_707,"[""B-cell lymphoma""]",,A non-Hodgkin lymphoma that has_material_basis_in B cells.,false,,,http://purl.obolibrary.org/obo/DOID_9500|http://purl.obolibrary.org/obo/DOID_0060060,,,,,,,,A non-Hodgkin lymphoma that has_material_basis_in B cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:707,,,,SNOMEDCT_US_2016_03_01:413616009|MESH:D016393|NCI:C3457|SNOMEDCT_US_2016_03_01:109979007|NCI:C27907|SNOMEDCT_US_2016_03_01:1929004|UMLS_CUI:C0079731,B-cell lymphocytic neoplasm,,disease_ontology,,DOID:707,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,B-cell lymphoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100275,"[""Tyrosine-protein kinase lyn""]",,"tyrosine-protein kinase lyn (LYN)  with  no mutation  in a nonphosphorylated state|A tyrosine-protein kinase Lyn that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07948] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300132,,,,,,,,"tyrosine-protein kinase lyn (LYN)  with  no mutation  in a nonphosphorylated state|A tyrosine-protein kinase Lyn that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07948] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100275,,,,https://pharos.nih.gov/idg/targets/P07948,,,,,,,,,,,,,LYN,JTK8,,P07948,,,,,,,,Tyrosine-protein kinase lyn,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000461,"[""HSDM1C1 cell""]",,Mouse Swiss Albino fibrosarcoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000460,,,,,,,,Mouse Swiss Albino fibrosarcoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000461,,,,,,,BrendaTissueOBO,,BTO:0000461,,,,,,,,,,,,,,,,,,,HSDM1C1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391037,"[""RIO1 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300217,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391037,,,,,,,,,,,,,,,,,,,,,,,,,,,,RIO1 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100713,"[""Olfactory receptor 9A4""]",,"An olfactory receptor 9A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGU2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 9A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGU2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100713,,,,https://pharos.nih.gov/idg/targets/Q8NGU2,,,,,,,,,,,,,OR9A4,,,Q8NGU2,,,,,,,,Olfactory receptor 9A4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000319,"[""NIM1 kinase domain""]",,Serine/threonine-protein kinase NIM1; MGC42105; NIM1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase NIM1; MGC42105; NIM1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000319,,,,,,,,,,,,,,,,,,,200295,,,,,,,,,NIM1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300288,"[""MSN subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300187,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300288,,,,,,,,,,,,,,,,,,,,,,,,,,,,MSN subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000419,"[""VAL379 in GCN2(Kin.Dom.2,S808G)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000419,,,,,,,,,,,,,,,,,,,,,,,,,,,,"VAL379 in GCN2(Kin.Dom.2,S808G)",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2444,"[""hyperpituitarism""]",,,false,,,http://purl.obolibrary.org/obo/DOID_53,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2444,,,,SNOMEDCT_US_2016_03_01:10649000|MESH:D006964|UMLS_CUI:C0020506|SNOMEDCT_US_2016_03_01:154698000|SNOMEDCT_US_2016_03_01:267480001,,,disease_ontology,,DOID:2444,,,,,,,,,,,,,,,,,,,hyperpituitarism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050860,"[""colorectal adenoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4610,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050860,lschriml,2014-05-05T03:14:49Z,,,,,disease_ontology,,DOID:0050860,,,,,,,,,,,,,,,,,,,colorectal adenoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300181,"[""NDR family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300181,,,,,,,,,,,,,,,,,,,,,,,,,,,,NDR family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400206,"[""VPS15 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400206,,,,,,,,,,,,,,,,,,,,,,,,,,,,VPS15 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217476,"[""Fushi tarazu f1-like receptors gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00200002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217476,,,,,,,,,,,,,,,,,,,,,,,,,,,,Fushi tarazu f1-like receptors gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004653,"[""pectoral fin""]",,"In fish, one of the pair of fins that are situated one on each side of the fish just behind the gills. Normally they are used for balancing and braking, but in some species, e.g. Exocoetidae, flying fish, the extra-large fins are used for jumping and for gliding over the water surface.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0004649,,,,,,,,"In fish, one of the pair of fins that are situated one on each side of the fish just behind the gills. Normally they are used for balancing and braking, but in some species, e.g. Exocoetidae, flying fish, the extra-large fins are used for jumping and for gliding over the water surface.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004653,mgr,2010-05-05T08:10:42Z,,,,,BrendaTissueOBO,,BTO:0004653,,,,,,,,,,,,,,,,,,,pectoral fin,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2473,"[""opportunistic mycosis""]",,"A systemic mycosis that results_in fungal infection located_in human body of immunocompromised individuals, has_material_basis_in Fungi. The organisms invade via the respiratory tract, alimentary tract, or intravascular devices.",false,,,http://purl.obolibrary.org/obo/DOID_0050136,,,,,,,,"A systemic mycosis that results_in fungal infection located_in human body of immunocompromised individuals, has_material_basis_in Fungi. The organisms invade via the respiratory tract, alimentary tract, or intravascular devices.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2473,,,DOID:0050137,SNOMEDCT_US_2016_03_01:187108005|ICD9CM:118|SNOMEDCT_US_2016_03_01:78999002|UMLS_CUI:C0029119,opportunistic systemic mycoses|Opportunistic mycoses (disorder)|Opportunistic mycosis (disorder),,disease_ontology,,DOID:2473,,,,,,,,,,,,,,,,,,,opportunistic mycosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000562,"[""heart""]",,1: A hollow muscular organ of vertebrate animals that by its rhythmic contraction acts as a force pump maintaining the circulation of the blood. 2: A structure in an invertebrate animal functionally analogous to the vertebrate heart.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,1: A hollow muscular organ of vertebrate animals that by its rhythmic contraction acts as a force pump maintaining the circulation of the blood. 2: A structure in an invertebrate animal functionally analogous to the vertebrate heart.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000562,,,,,,,BrendaTissueOBO,Herz,BTO:0000562,,,,,,,,,,,,,,,,,,,heart,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2571,"[""Langerhans-cell histiocytosis""]",,A histiocytosis that is characterized by clonal proliferation of Langerhans cells.,false,,,http://purl.obolibrary.org/obo/DOID_2529|http://purl.obolibrary.org/obo/DOID_3405,,,,,,,,A histiocytosis that is characterized by clonal proliferation of Langerhans cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2571,,,DOID:10624|DOID:10620|DOID:2554|DOID:10623|DOID:2553|DOID:10625|DOID:10617|DOID:9582|DOID:10618,SNOMEDCT_US_2016_03_01:190960001|ICD10CM:C96.0|ICD10CM:C96.6|SNOMEDCT_US_2016_03_01:188659009|NCI:C6920|SNOMEDCT_US_2016_03_01:267510005|OMIM:604856|SNOMEDCT_US_2016_03_01:65399007|MESH:D006646|MESH:C538636|SNOMEDCT_US_2016_03_01:154773005|SNOMEDCT_US_2016_03_01:234439008|NCI:C3107|SNOMEDCT_US_2016_03_01:236957004|ICD10CM:C96.5|UMLS_CUI:C0019621|SNOMEDCT_US_2016_03_01:118614007|SNOMEDCT_US_2016_03_01:188655003|SNOMEDCT_US_2016_03_01:110450007|OMIM:246400|ICD9CM:202.5|SNOMEDCT_US_2016_03_01:188654004|SNOMEDCT_US_2016_03_01:190956004|NCI:C3160|SNOMEDCT_US_2016_03_01:128811003|SNOMEDCT_US_2016_03_01:128809007|SNOMEDCT_US_2016_03_01:269628007|SNOMEDCT_US_2016_03_01:128812005|SNOMEDCT_US_2016_03_01:366059005|UMLS_CUI:C0023381|SNOMEDCT_US_2016_03_01:190955000|SNOMEDCT_US_2016_03_01:67574008|SNOMEDCT_US_2016_03_01:39795003|SNOMEDCT_US_2016_03_01:154583006,"Letterer-Siwe disease|Letterer-Siwe disease of lymph nodes of head, face and neck (disorder)|Letterer-Siwe disease of intrapelvic lymph nodes (disorder)|Letterer-Siwe disease involving lymph nodes of head, face and neck|Langerhans cell granulomatosis|Letterer-Siwe disease involving lymph nodes of multiple sites|Letterer-Siwe disease of intra-abdominal lymph nodes (disorder)|Letterer-Siwe disease of lymph nodes of head, face and/or neck (disorder)|Langerhan's cell histiocytosis (disorder)|Letterer-Siwe disease of lymph nodes of axilla and upper limb (disorder)|Letterer-Siwe disease of intrapelvic lymph nodes|Letterer-Siwe disease of spleen (disorder)|Letterer-Siwe disease involving intra-abdominal lymph nodes|Letterer-Siwe disease involving intrapelvic lymph nodes|Letterer-Siwe disease involving lymph nodes of axilla and upper limb|Histiocytosis X|Letterer-Siwe disease of lymph nodes of multiple sites|Letterer-Siwe disease of intrathoracic lymph nodes|Letterer-Siwe disease of lymph nodes of multiple sites (disorder)|Letterer-Siwe disease of spleen|Letterer-Siwe disease involving lymph nodes of inguinal region and lower limb|Letterer-Siwe disease of lymph nodes of inguinal region amd/or lower limb|Letterer-Siwe disease involving intrathoracic lymph nodes|Letterer-Siwe disease of lymph nodes of inguinal region and/or lower limb (disorder)|Letterer-Siwe disease of intra-abdominal lymph nodes|Letterer-Siwe disease involving spleen|Letterer-Siwe disease of intrathoracic lymph nodes (disorder)|Letterer-Siwe disease of lymph nodes of inguinal region and lower limb (disorder)|Letterer-Siwe disease involving lymph nodes of head, face, and neck|Letterer-Siwe disease of lymph nodes of axilla and/or upper limb (disorder)|Letterer-Siwe disease of lymph nodes of axilla and/or upper limb",,disease_ontology,,DOID:2571,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Langerhans-cell histiocytosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200226,"[""GRPR gene""]",,"A gastrin-releasing peptide receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30550] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400026,,,,,,,,"A gastrin-releasing peptide receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30550] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200226,,,,,,,,,,,,,,,,2925,GRPR,,,,,,,,,,,GRPR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000271,"[""MINK kinase domain""]",,Misshapen-like kinase 1 (zebrafish); B55; hMINK; hMINKbeta; MAP4K6; MGC21111; MINK; MINK/ZC3; MINK1; YSK2; ZC3,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Misshapen-like kinase 1 (zebrafish); B55; hMINK; hMINKbeta; MAP4K6; MGC21111; MINK; MINK/ZC3; MINK1; YSK2; ZC3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000271,,,,,,,,,,,,,,,,,,,200262,,,,,,,,,MINK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200091,"[""ORAI1 gene""]",,"The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400344,,,,,,,,"The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200091,,,,,,,,,,,,,,,,84876,ORAI1,CRACM1|TMEM142A,,,,,,,,,,ORAI1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300536,"[""Kv1.5/KCNA5 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300436,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300536,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv1.5/KCNA5 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200305,"[""OR10G8 gene""]",,"An olfactory receptor 10G8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10G8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200305,,,,,,,,,,,,,,,,219869,OR10G8,,,,,,,,,,,OR10G8 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200244,"[""PRKCI gene""]",,"This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400279,,,,,,,,"This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200244,,,,,,,,,,,,,,,,5584,PRKCI,DXS1179E,,,,,,,,,,PRKCI gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100283,"[""Phospholemman""]",,"A phospholemman that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00168] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300348,,,,,,,,"A phospholemman that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00168] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100283,,,,https://pharos.nih.gov/idg/targets/O00168,,,,,,,,,,,,,FXYD1,PLM,,O00168,,,,,,,,Phospholemman,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400150,"[""DYRK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400111,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400150,,,,,,,,,,,,,,,,,,,,,,,,,,,,DYRK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000345,"[""THR325 in TGFBR2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000345,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR325 in TGFBR2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2368,"[""gangliosidosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1927,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2368,,,,SNOMEDCT_US_2016_03_01:50967008|MESH:D005733|UMLS_CUI:C0017083|ICD10CM:E75.10,mucolipidosis type IV,,disease_ontology,,DOID:2368,,,,,,,,,,,,,,,,,,,gangliosidosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001001,"[""parietal lobe""]",,"The upper central lobe of the cerebral hemisphere, separated from the temporal lobe below by the lateral sulcus, but continuous at the posterior end of that sulcus, and separated from the frontal lobe by the central sulcus. Behind, it is continuous with the occipital lobe on the lateral surface, but separated from it by the parietooccipital sulcus on the medial surface.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The upper central lobe of the cerebral hemisphere, separated from the temporal lobe below by the lateral sulcus, but continuous at the posterior end of that sulcus, and separated from the frontal lobe by the central sulcus. Behind, it is continuous with the occipital lobe on the lateral surface, but separated from it by the parietooccipital sulcus on the medial surface.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001001,,,,,,,BrendaTissueOBO,parietal cortex,BTO:0001001,,,,,,,,,,,,,,,,,,,parietal lobe,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2602,"[""chondroma""]",,A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern.,false,,,http://purl.obolibrary.org/obo/DOID_0060084,,,,,,,,A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2602,,,,SNOMEDCT_US_2016_03_01:187899007|SNOMEDCT_US_2016_03_01:188980001|SNOMEDCT_US_2016_03_01:189885004|SNOMEDCT_US_2016_03_01:154611005|SNOMEDCT_US_2016_03_01:269638002|NCI:C53459|SNOMEDCT_US_2016_03_01:31186001|MESH:D002812|UMLS_CUI:C0936248,Chondroma NOS (morphologic abnormality)|Chondroma (morphologic abnormality)|central Chondroma,,disease_ontology,,DOID:2602,,,,,,,,,,,,,,,,,,,chondroma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000430,"[""TEC kinase domain""]",,Tyrosine-protein kinase Tec; MGC126760; MGC126762; PSCTK4; TEC,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Tyrosine-protein kinase Tec; MGC126760; MGC126762; PSCTK4; TEC,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000430,,,,,,,,,,,,,,,,,,,200431,,,,,,,,,TEC kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300345,"[""Cation channel sperm-associated family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300345,,,,,,,,,,,,,,,,,,,,,,,,,,,,Cation channel sperm-associated family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13208,"[""background diabetic retinopathy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_8947,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13208,,,,SNOMEDCT_US_2016_03_01:390834004|UMLS_CUI:C0004606|ICD9CM:362.01|SNOMEDCT_US_2016_03_01:154680004|ICD9CM:362.03|SNOMEDCT_US_2016_03_01:390718008|SNOMEDCT_US_2016_03_01:31411005|NCI:C34408|NCI:C35668,Non proliferative diabetic retinopathy|Non-Proliferative Diabetic Retinopathy,,disease_ontology,,DOID:13208,,,,,,,,,,,,,,,,,,,background diabetic retinopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13207,"[""proliferative diabetic retinopathy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_8947,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13207,,,,NCI:C84457|UMLS_CUI:C0154830|SNOMEDCT_US_2016_03_01:154679002|ICD9CM:362.02|SNOMEDCT_US_2016_03_01:59276001,PDR,,disease_ontology,,DOID:13207,,,,,,,,,,,,,,,,,,,proliferative diabetic retinopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13209,"[""right bundle branch block""]",,,false,,,http://purl.obolibrary.org/obo/DOID_10273,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13209,,,,ICD9CM:426.51|UMLS_CUI:C0155704|SNOMEDCT_US_2016_03_01:46319007,Right bundle branch block with left posterior fascicular block (disorder),,disease_ontology,,DOID:13209,,,,,,,,,,,,,,,,,,,right bundle branch block,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100149,"[""ATP-sensitive inward rectifier potassium channel 10""]",,"An ATP-sensitive inward rectifier potassium channel 10 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P78508] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300421,,,,,,,,"An ATP-sensitive inward rectifier potassium channel 10 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P78508] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100149,,,,https://pharos.nih.gov/idg/targets/P78508,,,,,,,,,,,,,KCNJ10,,,P78508,,,,,,,,ATP-sensitive inward rectifier potassium channel 10,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000291,"[""PHE90 in CAMK2G""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000291,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE90 in CAMK2G,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200721,"[""HCRTR1 gene""]",,An orexin receptor type 1 that is encoded in the genome of human. [Reactome:REACT_17344] ,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,An orexin receptor type 1 that is encoded in the genome of human. [Reactome:REACT_17344] ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200721,,,,,,,,,,,,,,,,3061,HCRTR1,,,,,,,,,,,HCRTR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400184,"[""LRRK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400107,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400184,,,,,,,,,,,,,,,,,,,,,,,,,,,,LRRK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200602,"[""OR4N4 gene""]",,"An olfactory receptor 4N4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N0Y3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4N4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8N0Y3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200602,,,,,,,,,,,,,,,,102723532|283694,OR4N4,,,,,,,,,,,OR4N4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200501,"[""STK33 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400135,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200501,,,,,,,,,,,,,,,,65975,STK33,,,,,,,,,,,STK33 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_679,"[""basal ganglia disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_936,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:679,,,,SNOMEDCT_US_2016_03_01:70835005|UMLS_CUI:C0004782|CSP:2057-3403|MESH:D001480,,,disease_ontology,,DOID:679,,,,,,,,,,,,,,,,,,,basal ganglia disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_678,"[""progressive supranuclear palsy""]",,"A movement disease characterized by serious and progressive problems with control of gait and balance, along with complex eye movement and thinking problems. It involves gradual deterioration and death of specific volumes of the brain.",false,,,http://purl.obolibrary.org/obo/DOID_480,,,,,,,,"A movement disease characterized by serious and progressive problems with control of gait and balance, along with complex eye movement and thinking problems. It involves gradual deterioration and death of specific volumes of the brain.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:678,,,,ICD10CM:G23.1|SNOMEDCT_US_2016_03_01:28978003|ORDO:683|OMIM:610898|NCI:C85028|OMIM:609454|SNOMEDCT_US_2016_03_01:192975003|UMLS_CUI:C0038868|MESH:D013494|OMIM:601104|SNOMEDCT_US_2016_03_01:192976002,progressive supranuclear ophthalmoplegia|Steele-Richardson-Olszewski syndrome,,disease_ontology,,DOID:678,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,progressive supranuclear palsy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_674,"[""cleft palate""]",,"An orofacial cleft characterized by a fissure of the soft and/or hard palate, due to faulty fusion of the two plates of the skull that form the hard palate.",false,,,http://purl.obolibrary.org/obo/DOID_0050567,,,,,,,,"An orofacial cleft characterized by a fissure of the soft and/or hard palate, due to faulty fusion of the two plates of the skull that form the hard palate.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:674,,,,SNOMEDCT_US_2016_03_01:156940009|MESH:D002972|SNOMEDCT_US_2016_03_01:253986002|SNOMEDCT_US_2016_03_01:268196005|NCI:C87069|SNOMEDCT_US_2016_03_01:204593009|ICD9CM:749.00|SNOMEDCT_US_2016_03_01:87979003|ORDO:99772|ICD9CM:749.0|UMLS_CUI:C0008925|ICD10CM:Q35.9|ICD10CM:Q35|SNOMEDCT_US_2016_03_01:204605001,Uranostaphyloschisis (disorder)|Palatoschisis|cleft velum,,disease_ontology,,DOID:674,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,cleft palate,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_676,"[""juvenile rheumatoid arthritis""]",,A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located_in joint.,false,,,http://purl.obolibrary.org/obo/DOID_7148,,,,,,,,A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located_in joint.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:676,,,DOID:1264|DOID:10129|DOID:675,MESH:D001171|UMLS_CUI:C0157918|ICD9CM:714.32|NCI:C26979|SNOMEDCT_US_2016_03_01:7441009|ICD9CM:714.3|OMIM:604302|SNOMEDCT_US_2016_03_01:201809006|ICD9CM:714.33|ICD9CM:714.31|NCI:C61279|UMLS_CUI:C0409667|SNOMEDCT_US_2016_03_01:74391003|SNOMEDCT_US_2016_03_01:83793004|UMLS_CUI:C0157917|SNOMEDCT_US_2016_03_01:201798003|ORDO:92|ICD10CM:M08.40|ICD10CM:M08.4|SNOMEDCT_US_2016_03_01:201799006|UMLS_CUI:C0157916|SNOMEDCT_US_2016_03_01:201803007|SNOMEDCT_US_2016_03_01:75822003,monarticular juvenile rheumatoid arthritis|juvenile chronic polyarthritis|Pauciarticular onset juvenile chronic arthritis|juvenile idiopathic arthritis|acute juvenile rheumatoid arthritis|pauciarticular juvenile arthritis|systemic juvenile rheumatoid arthritis,,disease_ontology,,DOID:676,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,juvenile rheumatoid arthritis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002205,"[""large cell lung cancer cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000762,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002205,,,,,,,BrendaTissueOBO,large cell carcinoma cell line,BTO:0002205,,,,,,,,,,,,,,,,,,,large cell lung cancer cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002612,"[""filopodium""]",,"A slender filamentous pseudopodium with a pointed end, branched or unbranched, consisting mostly of ectoplasm.",false,,,http://purl.obolibrary.org/obo/BTO_0002610|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A slender filamentous pseudopodium with a pointed end, branched or unbranched, consisting mostly of ectoplasm.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002612,,,,,,,BrendaTissueOBO,,BTO:0002612,,,,,,,,,,,,,,,,,,,filopodium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100266,"[""Tyrosine-protein kinase lck""]",,A tyrosine-protein kinase Lck that is encoded in the genome of human. |tyrosine-protein kinase lck (LCK)  with  no mutation  in a nonphosphorylated state,false,,,http://www.drugtargetontology.org/dto/DTO_03300132,,,,,,,,A tyrosine-protein kinase Lck that is encoded in the genome of human. |tyrosine-protein kinase lck (LCK)  with  no mutation  in a nonphosphorylated state,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100266,,,,https://pharos.nih.gov/idg/targets/P06239,,,,,,,,,,,,,LCK,,,P06239,,,,,,,,Tyrosine-protein kinase lck,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100687,"[""Olfactory receptor 8b3""]",,"An olfactory receptor 8B3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 8B3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100687,,,,https://pharos.nih.gov/idg/targets/Q8NGG8,,,,,,,,,,,,,OR8B3,,,Q8NGG8,,,,,,,,Olfactory receptor 8b3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000638,"[""interrenal cell""]",,Interrenal cells in elasmobranchs and bony fishes represent the equivalent of the mammalian adrenal cortex. The interrenal cells' appearance varies greatly in response to stress and reproduction. These cells produce corticosteroids with cortisol being the most quantitatively important.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Interrenal cells in elasmobranchs and bony fishes represent the equivalent of the mammalian adrenal cortex. The interrenal cells' appearance varies greatly in response to stress and reproduction. These cells produce corticosteroids with cortisol being the most quantitatively important.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000638,,,,,,,BrendaTissueOBO,,BTO:0000638,,,,,,,,,,,,,,,,,,,interrenal cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400053,"[""Purinoceptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400053,,,,,,,,,,,,,,,,,,,,,,,,,,,,Purinoceptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400123,"[""Alpha family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400108,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400123,,,,,,,,,,,,,,,,,,,,,,,,,,,,Alpha family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200417,"[""PIM1 gene""]",,"The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400207,,,,,,,,"The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200417,,,,,,,,,,,,,,,,5292,PIM1,,,,,,,,,,,PIM1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200009,"[""CHRNA4 gene""]",,"This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400493,,,,,,,,"This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200009,,,,,,,,,,,,,,,,1137,CHRNA4,NACRA4,,,,,,,,,,CHRNA4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000298,"[""MST3 kinase domain""]",,"Serine/threonine kinase 24 (STE20 homolog, yeast); MST3; MST3B; STE20; STK24; STK3",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Serine/threonine kinase 24 (STE20 homolog, yeast); MST3; MST3B; STE20; STK24; STK3",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000298,,,,,,,,,,,,,,,,,,,200275,,,,,,,,,MST3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200480,"[""SNRK gene""]",,"SNRK is a member of the sucrose nonfermenting (SNF)-related kinase family of serine/threonine kinases (Kertesz et al., 2002 [PubMed 12234663]).[supplied by OMIM, Apr 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03491038,,,,,,,,"SNRK is a member of the sucrose nonfermenting (SNF)-related kinase family of serine/threonine kinases (Kertesz et al., 2002 [PubMed 12234663]).[supplied by OMIM, Apr 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200480,,,,,,,,,,,,,,,,54861,SNRK,KIAA0096|SNFRK,,,,,,,,,,SNRK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001365,"[""thalamus""]",,The largest subdivision of the diencephalon that consists chiefly of an ovoid mass of nuclei in each lateral wall of the third ventricle and functions in the integration of sensory information.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The largest subdivision of the diencephalon that consists chiefly of an ovoid mass of nuclei in each lateral wall of the third ventricle and functions in the integration of sensory information.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001365,,,,,,,BrendaTissueOBO,thalamus dorsalis|dorsal thalamus,BTO:0001365,,,,,,,,,,,,,,,,,,,thalamus,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300517,"[""GABRG1 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300517,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRG1 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300150,"[""DYRK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300111,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300150,,,,,,,,,,,,,,,,,,,,,,,,,,,,DYRK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001078,"[""placenta""]",,The vascular organ in mammals except monotremes and marsupials that unites the fetus to the maternal uterus and mediates its metabolic exchanges through a more or less intimate association of uterine mucosal with chorionic and usually allantoic tissues; also: an analogous organ in another animal.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003099,,,,,,,,The vascular organ in mammals except monotremes and marsupials that unites the fetus to the maternal uterus and mediates its metabolic exchanges through a more or less intimate association of uterine mucosal with chorionic and usually allantoic tissues; also: an analogous organ in another animal.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001078,,,,,,,BrendaTissueOBO,,BTO:0001078,,,,,,,,,,,,,,,,,,,placenta,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000036,"[""gastric adenocarcinoma cell""]",,"A cell of any of a group of common stomach cancers, usually located in the antrum; it may present as a bulky mass with central ulceration invading the wall, a mass that narrows the antral lumen, a polypoid lesion, or a tumor that spreads superficially over the mucosal surface. It is common in Japan, Chile, Iceland, and Finland but the incidence is decreasing in North America and elsewhere. There may be links to certain dietary substances such as nitrosamines and benzpyrene.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000498|http://purl.obolibrary.org/obo/BTO_0000604,,,,,,,,"A cell of any of a group of common stomach cancers, usually located in the antrum; it may present as a bulky mass with central ulceration invading the wall, a mass that narrows the antral lumen, a polypoid lesion, or a tumor that spreads superficially over the mucosal surface. It is common in Japan, Chile, Iceland, and Finland but the incidence is decreasing in North America and elsewhere. There may be links to certain dietary substances such as nitrosamines and benzpyrene.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000036,,,,,,,BrendaTissueOBO,gastric carcinoma cell|adenocarcinoma cell of the stomach,BTO:0000036,,,,,,,,,,,,,,,,,,,gastric adenocarcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400099,"[""Endothelin type B gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400038,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400099,,,,,,,,,,,,,,,,,,,,,,,,,,,,Endothelin type B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002979,"[""secretion""]",,Material that is secreted as a result of the activity of a gland; this activity may range from separating a specific substance of the blood to the elaboration of a new chemical substance.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Material that is secreted as a result of the activity of a gland; this activity may range from separating a specific substance of the blood to the elaboration of a new chemical substance.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002979,,,,,,,BrendaTissueOBO,,BTO:0002979,,,,,,,,,,,,,,,,,,,secretion,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200049,"[""CACNB2 gene""]",,"This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_01400334,,,,,,,,"This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200049,,,,,,,,,,,,,,,,783,CACNB2,CACNLB2|MYSB,,,,,,,,,,CACNB2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300560,"[""Kv12.1/KCNH8 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300448,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300560,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv12.1/KCNH8 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200214,"[""KCNK2 gene""]",,"This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400359,,,,,,,,"This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200214,,,,,,,,,,,,,,,,3776,KCNK2,TREK|TREK1,,,,,,,,,,KCNK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80242,"[""Endothelin-2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16012,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80242,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80242,,,,,Endothelin-2,,CHEBI:80242,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000306,"[""teratocarcinoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001560,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000306,,,,,,,BrendaTissueOBO,,BTO:0000306,,,,,,,,,,,,,,,,,,,teratocarcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002919,"[""retinoblastoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000711,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002919,,,,,,,BrendaTissueOBO,,BTO:0002919,,,,,,,,,,,,,,,,,,,retinoblastoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_15632,"[""5(S)-HPETE""]","(5S,6E,8Z,11Z,14Z)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid|CCCCC\C=C/C\C=C/C\C=C/C=C/[C@H](CCCC(O)=O)OO|5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid|C20H32O4|(6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate|(5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid|5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate|(S)-5-HPETE|5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid|5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid|336.230|336.46568|JNUUNUQHXIOFDA-JGKLHWIESA-N|InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1|(6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid|0|5S-HpETE|(5S,6E,8Z,11Z,14Z)-5-Hydroperoxyicosa-6,8,11,14-tetraenoate","An icosatetraenoic acid in which the double bonds are located at the 6-7, 8-9, 11-12, and 14-15 positions and have E, Z, Z, and Z geometry, respectively, and in which the pro-S hydrogen is substituted by a hydroperoxy group.",false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,Reaxys:5282501|KEGG:C05356|CAS:71774-08-8|HMDB:HMDB11135|LIPID_MAPS_instance:LMFA03060012,"An icosatetraenoic acid in which the double bonds are located at the 6-7, 8-9, 11-12, and 14-15 positions and have E, Z, Z, and Z geometry, respectively, and in which the pro-S hydrogen is substituted by a hydroperoxy group.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:60942|CHEBI:20573|CHEBI:18601|CHEBI:2061|CHEBI:10924,,"(5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid|5(S)-HPETE",,chebi_ontology,"(5S,6E,8Z,11Z,14Z)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid|CCCCC\C=C/C\C=C/C\C=C/C=C/[C@H](CCCC(O)=O)OO|5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid|C20H32O4|(6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate|(5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid|5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate|(S)-5-HPETE|5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid|5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid|336.230|336.46568|JNUUNUQHXIOFDA-JGKLHWIESA-N|InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1|(6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid|0|5S-HpETE|(5S,6E,8Z,11Z,14Z)-5-Hydroperoxyicosa-6,8,11,14-tetraenoate",,,CHEBI:15632,,,,,,,,,,,,,,,,,,,,,,,CHEBI:15632,,,,,5(S)-HPETE,,CHEBI:15632,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300422,"[""KCNJ11 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300422,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ11 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200190,"[""KCNC2 gene""]",,"The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400542,,,,,,,,"The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200190,,,,,,,,,,,,,,,,3747,KCNC2,,,,,,,,,,,KCNC2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100808,"[""Transmembrane protein adipocyte-associated 1""]",,"A transmembrane protein adipocyte-associated 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86W33] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300090,,,,,,,,"A transmembrane protein adipocyte-associated 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86W33] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100808,,,,https://pharos.nih.gov/idg/targets/Q86W33,,,,,,,,,,,,,TPRA1,GPR175|TMEM227,,Q86W33,,,,,,,,Transmembrane protein adipocyte-associated 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000271,"[""PHE691 in FLT3(D835Y)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000271,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE691 in FLT3(D835Y),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004621,"[""OCI-AML5 cell""]",,Human acute myeloid leukemia cell line; established from the peripheral blood of a 77-year-old man with acute myeloid leukemia.,false,,,http://purl.obolibrary.org/obo/BTO_0001883|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human acute myeloid leukemia cell line; established from the peripheral blood of a 77-year-old man with acute myeloid leukemia.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004621,mgr,2010-04-13T09:22:50Z,,,,,BrendaTissueOBO,OCI-AML-5 cell|OCI/AML-5 cell|OCI AML5 cell,BTO:0004621,,,,,,,,,,,,,,,,,,,OCI-AML5 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100092,"[""Calsenilin""]",,"A calsenilin that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y2W7] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,"A calsenilin that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y2W7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100092,,,,https://pharos.nih.gov/idg/targets/Q9Y2W7,,,,,,,,,,,,,KCNIP3,CSEN|DREAM|KCHIP3,,Q9Y2W7,,,,,,,,Calsenilin,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1037,"[""lymphoblastic leukemia""]",,A leukemia that has_material_basis_in lymphoblasts (immature white blood cells).,false,,,http://purl.obolibrary.org/obo/DOID_1240,,,,,,,,A leukemia that has_material_basis_in lymphoblasts (immature white blood cells).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1037,,,,MESH:D007945|SNOMEDCT_US_2016_03_01:269631008|SNOMEDCT_US_2016_03_01:190033006|SNOMEDCT_US_2016_03_01:93170002|ICD9CM:204.9|ICD10CM:C91|SNOMEDCT_US_2016_03_01:188731001|UMLS_CUI:C0023448|ICD10CM:C91.9|SNOMEDCT_US_2016_03_01:32280000|ICD10CM:C91.90|SNOMEDCT_US_2016_03_01:188725004|NCI:C7539|SNOMEDCT_US_2016_03_01:154587007|ICD9CM:204,,,disease_ontology,,DOID:1037,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,lymphoblastic leukemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10375,"[""suppression amblyopia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_10376,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10375,,,,SNOMEDCT_US_2016_03_01:35600002|MESH:D000550|ICD9CM:368.01|ICD10CM:H53.03|UMLS_CUI:C0750903,Strabismic amblyopia,,disease_ontology,,DOID:10375,,,,,,,,,,,,,,,,,,,suppression amblyopia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10376,"[""amblyopia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5614,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10376,,,,ICD10CM:H53.00|SNOMEDCT_US_2016_03_01:155145007|SNOMEDCT_US_2016_03_01:267726008|SNOMEDCT_US_2016_03_01:387742006|UMLS_CUI:C0002418|CSP:1114-9655|MESH:D000550|ICD9CM:368.00|SNOMEDCT_US_2016_03_01:193637007|SNOMEDCT_US_2016_03_01:111517004|SNOMEDCT_US_2016_03_01:267627009|NCI:C118764,,,disease_ontology,,DOID:10376,,,,,,,,,,,,,,,,,,,amblyopia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10378,"[""disuse amblyopia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_10376,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10378,,,,ICD10CM:H53.01|UMLS_CUI:C0152189|SNOMEDCT_US_2016_03_01:21457000|ICD9CM:368.02|SNOMEDCT_US_2016_03_01:193638002,Deprivation amblyopia,,disease_ontology,,DOID:10378,,,,,,,,,,,,,,,,,,,disuse amblyopia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_332,"[""amyotrophic lateral sclerosis""]",,"A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing.",false,,,http://purl.obolibrary.org/obo/DOID_231,,,,,,,,"A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:332,,,,ICD9CM:335.20|MESH:D000690|EFO:0000253|OMIM:PS105400|SNOMEDCT_US_2016_03_01:86044005|KEGG:05014|UMLS_CUI:C0002736|ICD10CM:G12.21|NCI:C34373,"motor neuron disease, bulbar|Lou Gehrig's disease|ALS",,disease_ontology,,DOID:332,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,amyotrophic lateral sclerosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_338,"[""cranial nerve neoplasm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:338,,,,,,,,,,,,,,,,,,,,,,,,,,,,cranial nerve neoplasm,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_331,"[""central nervous system disease""]",,A nervous system disease that affects either the spinal cord (myelopathy) or brain (encephalopathy) of the central nervous system.,false,,,http://purl.obolibrary.org/obo/DOID_863,,,,,,,,A nervous system disease that affects either the spinal cord (myelopathy) or brain (encephalopathy) of the central nervous system.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:331,,,,SNOMEDCT_US_2016_03_01:267702006|SNOMEDCT_US_2016_03_01:192641002|ICD10CM:G96.9|SNOMEDCT_US_2016_03_01:23853001|SNOMEDCT_US_2016_03_01:275539005|NCI:C2934|SNOMEDCT_US_2016_03_01:267144009|UMLS_CUI:C0007682|SNOMEDCT_US_2016_03_01:154981003|SNOMEDCT_US_2016_03_01:155049004|SNOMEDCT_US_2016_03_01:138748005|SNOMEDCT_US_2016_03_01:193076009|SNOMEDCT_US_2016_03_01:155059003|SNOMEDCT_US_2016_03_01:267700003|SNOMEDCT_US_2016_03_01:267679005|SNOMEDCT_US_2016_03_01:194566008|MESH:D002493,,,disease_ontology,,DOID:331,,,,,,,,,,,,,,,,,,,central nervous system disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_334,"[""histrionic personality disorder""]",,"A personality disorder that is characterized by a pattern of excessive emotionality and attention-seeking, including an excessive need for approval and inappropriately seductive behavior, usually beginning in early adulthood.",false,,,http://purl.obolibrary.org/obo/DOID_1510,,,,,,,,"A personality disorder that is characterized by a pattern of excessive emotionality and attention-seeking, including an excessive need for approval and inappropriately seductive behavior, usually beginning in early adulthood.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:334,,,,UMLS_CUI:C0019681|ICD10CM:F60.4|SNOMEDCT_US_2016_03_01:268758001|MESH:D006677|SNOMEDCT_US_2016_03_01:154900000|NCI:C92634|ICD9CM:301.5|SNOMEDCT_US_2016_03_01:191764009|ICD9CM:301.50|SNOMEDCT_US_2016_03_01:55341008|SNOMEDCT_US_2016_03_01:191767002|SNOMEDCT_US_2016_03_01:192489002,,,disease_ontology,,DOID:334,,,,,,,,,,,,,,,,,,,histrionic personality disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200798,"[""TAS2R8 gene""]",,"A taste receptor type 2 member 8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400014,,,,,,,,"A taste receptor type 2 member 8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200798,,,,,,,,,,,,,,,,50836,TAS2R8,,,,,,,,,,,TAS2R8 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100570,"[""Olfactory receptor 4c5""]",,"An olfactory receptor 4C5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4C5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGB2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100570,,,,https://pharos.nih.gov/idg/targets/Q8NGB2,,,,,,,,,,,,,OR4C5,,,Q8NGB2,,,,,,,,Olfactory receptor 4c5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100597,"[""Olfactory receptor 4k17""]",,"An olfactory receptor 4K17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4K17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100597,,,,https://pharos.nih.gov/idg/targets/Q8NGC6,,,,,,,,,,,,,OR4K17,,,Q8NGC6,,,,,,,,Olfactory receptor 4k17,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100352,"[""Myosin-iiib""]",,"A myosin-IIIB that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WXR4] |myosin-IIIb (MYO3B)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300298,,,,,,,,"A myosin-IIIB that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WXR4] |myosin-IIIb (MYO3B)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100352,,,,https://pharos.nih.gov/idg/targets/Q8WXR4,,,,,,,,,,,,,MYO3B,,,Q8WXR4,,,,,,,,Myosin-iiib,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200104,"[""DCLK3 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400147,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200104,,,,,,,,,,,,,,,,85443,DCLK3,DCAMKL3|DCDC3C|KIAA1765,,,,,,,,,,DCLK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3529,"[""central core myopathy""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_422,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3529,,,,SNOMEDCT_US_2016_03_01:43152001|OMIM:117000|ICD10CM:G71.2|NCI:C83010|MESH:D020512|UMLS_CUI:C0751951,central core disease (disorder)|central core disease,,disease_ontology,,DOID:3529,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,central core myopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217564,"[""ESRRB gene""]",,"This gene encodes a protein with similarity to the estrogen receptor. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_00217473,,,,,,,,"This gene encodes a protein with similarity to the estrogen receptor. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217564,,,,,,,,,,,,,,,,2103,ESRRB,ERRB2|ESRL2|NR3B2,,,,,,,,,,ESRRB gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002781,"[""mesenteric vein""]",,One of the large veins which return blood from the intestines.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000234,,,,,,,,One of the large veins which return blood from the intestines.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002781,,,,,,,BrendaTissueOBO,,BTO:0002781,,,,,,,,,,,,,,,,,,,mesenteric vein,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004641,"[""tracheal cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004641,mgr,2010-04-16T09:16:55Z,,,,,BrendaTissueOBO,,BTO:0004641,,,,,,,,,,,,,,,,,,,tracheal cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001844,"[""tooth enamel""]",,"The hard, calcareous substance covering the exposed portion of a tooth.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The hard, calcareous substance covering the exposed portion of a tooth.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001844,,,,,,,BrendaTissueOBO,enamel,BTO:0001844,,,,,,,,,,,,,,,,,,,tooth enamel,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000542,"[""granulosa cell""]",,One of the estrogen-secreting cells of the epithelial lining of a graafian follicle or its follicular precursor.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,One of the estrogen-secreting cells of the epithelial lining of a graafian follicle or its follicular precursor.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000542,,,,,,,BrendaTissueOBO,ovarian granulosa cell,BTO:0000542,,,,,,,,,,,,,,,,,,,granulosa cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200239,"[""KCNS3 gene""]",,"Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_01400568,,,,,,,,"Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200239,,,,,,,,,,,,,,,,3790,KCNS3,,,,,,,,,,,KCNS3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200509,"[""STRADA gene""]",,"The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400187,,,,,,,,"The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200509,,,,,,,,,,,,,,,,92335,STRADA,LYK5|STRAD,,,,,,,,,,STRADA gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000790,"[""pharyngeal cancer cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000819,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000790,,,,,,,BrendaTissueOBO,pharynx carcinoma cell line,BTO:0000790,,,,,,,,,,,,,,,,,,,pharyngeal cancer cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001437,"[""embryonic carcinoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000669,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001437,,,,,,,BrendaTissueOBO,,BTO:0001437,,,,,,,,,,,,,,,,,,,embryonic carcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000244,"[""M3K13 kinase domain""]",,Mitogen-activated protein kinase kinase kinase 13; LZK; MAP3K13; MEKK13; MGC133196,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase kinase kinase 13; LZK; MAP3K13; MEKK13; MGC133196,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000244,,,,,,,,,,,,,,,,,,,200233,,,,,,,,,M3K13 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200514,"[""TAOK1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400318,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200514,,,,,,,,,,,,,,,,57551,TAOK1,KIAA1361|MAP3K16|MARKK,,,,,,,,,,TAOK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200063,"[""TMEM37 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400391,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200063,,,,,,,,,,,,,,,,140738,TMEM37,PR,,,,,,,,,,TMEM37 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100651,"[""Olfactory receptor 6b1""]",,"An olfactory receptor 6B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95007] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95007] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100651,,,,https://pharos.nih.gov/idg/targets/O95007,,,,,,,,,,,,,OR6B1,,,O95007,,,,,,,,Olfactory receptor 6b1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300473,"[""Nav1.6/SCN8A subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300369,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300473,,,,,,,,,,,,,,,,,,,,,,,,,,,,Nav1.6/SCN8A subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200551,"[""OR2T7 gene""]",,"An olfactory receptor 2T7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7T2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2T7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7T2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200551,,,,,,,,,,,,,,,,81458,OR2T7,OR2T7P,,,,,,,,,,OR2T7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400136,"[""CDK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400111,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400136,,,,,,,,,,,,,,,,,,,,,,,,,,,,CDK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100827,"[""Putative olfactory receptor 13c6""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100827,,,,https://pharos.nih.gov/idg/targets/Q8NH95,,,,,,,,,,,,,OR13C6P,,,Q8NH95,,,,,,,,Putative olfactory receptor 13c6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300418,"[""GRIK3 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300418,,,,,,,,,,,,,,,,,,,,,,,,,,,,GRIK3 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200485,"[""OR1E2 gene""]",,"An olfactory receptor 1E2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47887] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1E2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47887] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200485,,,,,,,,,,,,,,,,8388,OR1E2,OR1E4,,,,,,,,,,OR1E2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200782,"[""TAS2R30 gene""]",,"A taste receptor type 2 member 30 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59541] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400014,,,,,,,,"A taste receptor type 2 member 30 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59541] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200782,,,,,,,,,,,,,,,,259293,TAS2R30,TAS2R47,,,,,,,,,,TAS2R30 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200146,"[""GPR141 gene""]",,"A G-protein coupled receptor 141 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q7Z602] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 141 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q7Z602] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200146,,,,,,,,,,,,,,,,353345,GPR141,PGR13,,,,,,,,,,GPR141 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300154,"[""IRE family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300154,,,,,,,,,,,,,,,,,,,,,,,,,,,,IRE family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3672,"[""rhabdoid cancer""]",,"A childhood kidney neoplasm that is located_in the in the kidney as well as other locations outside the kidneys such as the liver, muscle, heart, lung, soft tissues, skin, the central nervous system.",false,,,http://purl.obolibrary.org/obo/DOID_3675,,,,,,,,"A childhood kidney neoplasm that is located_in the in the kidney as well as other locations outside the kidneys such as the liver, muscle, heart, lung, soft tissues, skin, the central nervous system.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3672,,,,SNOMEDCT_US_2016_03_01:83118000|UMLS_CUI:C0206743|NCI:C3808|SNOMEDCT_US_2016_03_01:189812005|MESH:D018335,Rhabdoid sarcoma|malignant rhabdoid tumour,,disease_ontology,rhabdoid tumor,DOID:3672,,,,,,,,,,,,,,,,,,,rhabdoid cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000348,"[""PIK3CA(I800L) kinase domain""]",,"Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000348,,,,,,,,,,,,,,,,,,,200330,,,,,,,,,PIK3CA(I800L) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100030,"[""Bestrophin-1""]",,"A bestrophin-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76090] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300331,,,,,,,,"A bestrophin-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76090] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100030,,,,https://pharos.nih.gov/idg/targets/O76090,,,,,,,,,,,,,BEST1,VMD2,,O76090,,,,,,,,Bestrophin-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000574,"[""hematopoietic cell""]",,A blood cell.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A blood cell.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000574,,,,,,,BrendaTissueOBO,haemopoietic cell|haematopoietic cell|hemopoietic cell|blood cell,BTO:0000574,,,,,,,,,,,,,,,,,,,hematopoietic cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200404,"[""OR51Q1 gene""]",,"An olfactory receptor 51Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH59] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 51Q1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH59] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200404,,,,,,,,,,,,,,,,390061,OR51Q1,,,,,,,,,,,OR51Q1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10718,"[""giardiasis""]",,"A parasitic protozoa infectious disease that involves infection of the small intestine by a single-celled enteric protozoan parasite Giardia intestinalis. The symptoms include greasy and malodorous stools, diarrhea, abdominal pain, bloating, nausea, and vomiting.",false,,,http://purl.obolibrary.org/obo/DOID_2789,,,,,,,,"A parasitic protozoa infectious disease that involves infection of the small intestine by a single-celled enteric protozoan parasite Giardia intestinalis. The symptoms include greasy and malodorous stools, diarrhea, abdominal pain, bloating, nausea, and vomiting.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10718,,,,ICD10CM:A07.1|SNOMEDCT_US_2016_03_01:266176008|UMLS_CUI:C0017536|MESH:D005873|SNOMEDCT_US_2016_03_01:154275004|ICD9CM:007.1|SNOMEDCT_US_2016_03_01:10679007|SNOMEDCT_US_2016_03_01:58265007|SNOMEDCT_US_2016_03_01:266075009|SNOMEDCT_US_2016_03_01:186124000,beaver feaver|Infection by Giardia lamblia,,disease_ontology,,DOID:10718,,,,,,,,,,,,,,,,,,,giardiasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100299,"[""Putative olfactory receptor 10d4""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100299,,,,https://pharos.nih.gov/idg/targets/Q8NGN7,,,,,,,,,,,,,OR10D4P,OR10D4,,Q8NGN7,,,,,,,,Putative olfactory receptor 10d4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100326,"[""Olfactory receptor 10x1""]",,"An olfactory receptor 10X1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10X1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100326,,,,https://pharos.nih.gov/idg/targets/Q8NGY0,,,,,,,,,,,,,OR10X1,OR10X1P,,Q8NGY0,,,,,,,,Olfactory receptor 10x1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000317,"[""NEK7 kinase domain""]",,NIMA (never in mitosis gene a)-related kinase 7; NEK7,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,NIMA (never in mitosis gene a)-related kinase 7; NEK7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000317,,,,,,,,,,,,,,,,,,,200293,,,,,,,,,NEK7 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100492,"[""Olfactory receptor 1J1""]",,"An olfactory receptor 1J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100492,,,,https://pharos.nih.gov/idg/targets/Q8NGS3,,,,,,,,,,,,,OR1J1,,,Q8NGS3,,,,,,,,Olfactory receptor 1J1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004721,"[""myeloid dendritic cell""]",,"The most common division of dendritic cells is myeloid versus plasmacytoid. The myeloid dendritic cells are developed from myeloid precursors and are most similar to monocytes. They are made up of at least two subsets: 1. the more common mDC-1, which is a major stimulator of T cells and 2. the extremely rare mDC-2, which may have a function in fighting wound infection. They secrete IL-12.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002042,,,,,,,,"The most common division of dendritic cells is myeloid versus plasmacytoid. The myeloid dendritic cells are developed from myeloid precursors and are most similar to monocytes. They are made up of at least two subsets: 1. the more common mDC-1, which is a major stimulator of T cells and 2. the extremely rare mDC-2, which may have a function in fighting wound infection. They secrete IL-12.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004721,mgr,2010-07-23T09:04:22Z,,,,,BrendaTissueOBO,mDC cell,BTO:0004721,,,,,,,,,,,,,,,,,,,myeloid dendritic cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000935,"[""LAN-5 cell""]",,Human neuroblastoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000932,,,,,,,,Human neuroblastoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000935,,,,,,,BrendaTissueOBO,LAN5 cell,BTO:0000935,,,,,,,,,,,,,,,,,,,LAN-5 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100153,"[""Probable g-protein coupled receptor 150""]",,"A G-protein coupled receptor 150 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8NGU9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A G-protein coupled receptor 150 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8NGU9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100153,,,,https://pharos.nih.gov/idg/targets/Q8NGU9,,,,,,,,,,,,,GPR150,,,Q8NGU9,,,,,,,,Probable g-protein coupled receptor 150,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400298,"[""NinaC subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400187,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400298,,,,,,,,,,,,,,,,,,,,,,,,,,,,NinaC subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300319,"[""TESK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300182,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300319,,,,,,,,,,,,,,,,,,,,,,,,,,,,TESK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000396,"[""RSK2(Kin.Dom.1-N-terminal) kinase domain""]",,"Ribosomal protein S6 kinase, 90kDa, polypeptide 3; CLS; HU-3; ISPK-1; MAPKAPK1B; MRX19; p90-RSK2; pp90RSK2; RPS6KA3; RSK; RSK2; S6K-alpha3",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Ribosomal protein S6 kinase, 90kDa, polypeptide 3; CLS; HU-3; ISPK-1; MAPKAPK1B; MRX19; p90-RSK2; pp90RSK2; RPS6KA3; RSK; RSK2; S6K-alpha3",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000396,,,,,,,,,,,,,,,,,,,"200388, 200401",,,,,,,,,RSK2(Kin.Dom.1-N-terminal) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100284,"[""Neuropeptide y receptor type 5""]",,"A neuropeptide Y receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15761] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300071,,,,,,,,"A neuropeptide Y receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15761] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100284,,,,https://pharos.nih.gov/idg/targets/Q15761,,,,,,,,,,,,,NPY5R,NPYR5,,Q15761,,,,,,,,Neuropeptide y receptor type 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100551,"[""Olfactory receptor 2T7""]",,"An olfactory receptor 2T7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7T2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2T7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7T2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100551,,,,https://pharos.nih.gov/idg/targets/P0C7T2,,,,,,,,,,,,,OR2T7,OR2T7P,,P0C7T2,,,,,,,,Olfactory receptor 2T7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002038,"[""osteocyte""]",,A cell that is characteristic of adult bone and is isolated in a lacuna of the bone substance.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002050,,,,,,,,A cell that is characteristic of adult bone and is isolated in a lacuna of the bone substance.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002038,,,,,,,BrendaTissueOBO,,BTO:0002038,,,,,,,,,,,,,,,,,,,osteocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400402,"[""CNGA1 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400343,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400402,,,,,,,,,,,,,,,,,,,,,,,,,,,,CNGA1 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100446,"[""Olfactory receptor 5AC2""]",,"An olfactory receptor 5AC2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZP5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5AC2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZP5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100446,,,,https://pharos.nih.gov/idg/targets/Q9NZP5,,,,,,,,,,,,,OR5AC2,,,Q9NZP5,,,,,,,,Olfactory receptor 5AC2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200315,"[""OR10J5 gene""]",,"An olfactory receptor 10J5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHC4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10J5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHC4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200315,,,,,,,,,,,,,,,,127385,OR10J5,,,,,,,,,,,OR10J5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200479,"[""OR1B1 gene""]",,"An olfactory receptor 1B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 1B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGR6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200479,,,,,,,,,,,,,,,,347169,OR1B1,,,,,,,,,,,OR1B1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300153,"[""EPH family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300153,,,,,,,,,,,,,,,,,,,,,,,,,,,,EPH family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400122,"[""ALK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400122,,,,,,,,,,,,,,,,,,,,,,,,,,,,ALK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000439,"[""eye""]",,"An organ of sight; especially: a nearly spherical hollow organ that is lined with a sensitive retina, is lodged in a bony orbit in the skull, is the vertebrate organ of sight, and is normally paired.",false,,,http://purl.obolibrary.org/obo/BTO_0000202|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"An organ of sight; especially: a nearly spherical hollow organ that is lined with a sensitive retina, is lodged in a bony orbit in the skull, is the vertebrate organ of sight, and is normally paired.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000439,,,,,,,BrendaTissueOBO,visual system|visual apparatus,BTO:0000439,,,,,,,,,,,,,,,,,,,eye,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000120,"[""MET135 in MARK4""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000120,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET135 in MARK4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3690,"[""brachial plexus neuropathy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_870,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3690,,,,ICD10CM:G54.0|UMLS_CUI:C0700251|NCI:C27194|MESH:D020516|SNOMEDCT_US_2016_03_01:3548001,Brachial plexus disorder|brachial plexopathy,,disease_ontology,,DOID:3690,,,,,,,,,,,,,,,,,,,brachial plexus neuropathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8596,"[""scarlet fever""]",,"An upper respiratory tract disease described as an acute contagious disease caused by Group A bacteria of the genus Streptococcus (especially various strains of S. pyogenes) and characterized by inflammation of the nose, throat, and mouth, generalized toxemia, and a red rash.",false,,,http://purl.obolibrary.org/obo/DOID_974,,,,,,,,"An upper respiratory tract disease described as an acute contagious disease caused by Group A bacteria of the genus Streptococcus (especially various strains of S. pyogenes) and characterized by inflammation of the nose, throat, and mouth, generalized toxemia, and a red rash.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8596,,,DOID:8597,SNOMEDCT_US_2016_03_01:154303009|SNOMEDCT_US_2016_03_01:154301006|NCI:C94575|UMLS_CUI:C0036285|MESH:D012541|SNOMEDCT_US_2016_03_01:186357007|ICD10CM:A38.9|SNOMEDCT_US_2016_03_01:154304003|SNOMEDCT_US_2016_03_01:186362008|UMLS_CUI:C0343487|ICD9CM:034.1|ICD9CM:034|SNOMEDCT_US_2016_03_01:30242009|ICD10CM:A38,Scarlatina,,disease_ontology,,DOID:8596,,,,,,,,,,,,,,,,,,,scarlet fever,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100163,"[""Atp-sensitive inward rectifier potassium channel 8""]",,"An ATP-sensitive inward rectifier potassium channel 8 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15842] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300434,,,,,,,,"An ATP-sensitive inward rectifier potassium channel 8 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15842] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100163,,,,https://pharos.nih.gov/idg/targets/Q15842,,,,,,,,,,,,,KCNJ8,,,Q15842,,,,,,,,Atp-sensitive inward rectifier potassium channel 8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000370,"[""THR670 in KIT(D816H)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000370,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR670 in KIT(D816H),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4231,"[""histiocytoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_201,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4231,,,,SNOMEDCT_US_2016_03_01:302843004|SNOMEDCT_US_2016_03_01:128741006|NCI:C35765|MESH:D051642|SNOMEDCT_US_2016_03_01:72079004|UMLS_CUI:C1509147|SNOMEDCT_US_2016_03_01:154614002|SNOMEDCT_US_2016_03_01:189773000,,,disease_ontology,,DOID:4231,,,,,,,,,,,,,,,,,,,histiocytoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000366,"[""THR663 in CSF1R""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000366,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR663 in CSF1R,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100426,"[""Olfactory receptor 52k2""]",,"An olfactory receptor 52K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 52K2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100426,,,,https://pharos.nih.gov/idg/targets/Q8NGK3,,,,,,,,,,,,,OR52K2,,,Q8NGK3,,,,,,,,Olfactory receptor 52k2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200351,"[""MYO3A gene""]",,"The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400298,,,,,,,,"The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200351,,,,,,,,,,,,,,,,53904,MYO3A,,,,,,,,,,,MYO3A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2340,"[""craniosynostosis""]",,A synostosis that results_in premature fusion located_in skull.,false,,,http://purl.obolibrary.org/obo/DOID_11971,,,,,,,,A synostosis that results_in premature fusion located_in skull.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2340,,,,OMIM:604757|MESH:D003398|ICD10CM:Q75.0|NCI:C84655|ORDO:1531|OMIM:600775|SNOMEDCT_US_2016_03_01:205414007|OMIM:615529|OMIM:123100|OMIM:600593|OMIM:182212|SNOMEDCT_US_2016_03_01:205411004|SNOMEDCT_US_2016_03_01:57219006|OMIM:615314|UMLS_CUI:C0010278,Premature closure of cranial sutures,,disease_ontology,,DOID:2340,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].
OMIM mapping by NeuroDevNet. [LS].",,craniosynostosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100690,"[""Olfactory receptor 8B12""]",,"An olfactory receptor 8B12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 8B12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGG6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100690,,,,https://pharos.nih.gov/idg/targets/Q8NGG6,,,,,,,,,,,,,OR8B12,,,Q8NGG6,,,,,,,,Olfactory receptor 8B12,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002392,"[""SGC-7901 cell""]",,Human gastric cancer cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000787,,,,,,,,Human gastric cancer cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002392,,,,,,,BrendaTissueOBO,SGC7901 cell,BTO:0002392,,,,,,,,,,,,,,,,,,,SGC-7901 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400287,"[""KHS subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400187,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400287,,,,,,,,,,,,,,,,,,,,,,,,,,,,KHS subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100035,"[""Aurora kinase a""]",,aurora kinase a (AURKA)  with  no mutation  in a nonphosphorylated state|An aurora kinase A that is encoded in the genome of human. [PRO:KER] ,false,,,http://www.drugtargetontology.org/dto/DTO_03300130,,,,,,,,aurora kinase a (AURKA)  with  no mutation  in a nonphosphorylated state|An aurora kinase A that is encoded in the genome of human. [PRO:KER] ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100035,,,,https://pharos.nih.gov/idg/targets/O14965,,,,,,,,,,,,,AURKA,AIK|AIRK1|ARK1|AURA|AYK1|BTAK|IAK1|STK15|STK6,,O14965,,,,,,,,Aurora kinase a,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100007,"[""Neuronal acetylcholine receptor subunit alpha-2""]",,"A neuronal acetylcholine receptor subunit alpha-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15822] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300491,,,,,,,,"A neuronal acetylcholine receptor subunit alpha-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15822] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100007,,,,https://pharos.nih.gov/idg/targets/Q15822,,,,,,,,,,,,,CHRNA2,,,Q15822,,,,,,,,Neuronal acetylcholine receptor subunit alpha-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400141,"[""PDGFR family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400141,,,,,,,,,,,,,,,,,,,,,,,,,,,,PDGFR family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6682,"[""spondylolisthesis""]",,A bone structure disease that has_material_basis_in displacement located_in set of vertebrae.,false,,,http://purl.obolibrary.org/obo/DOID_0080010,,,,,,,,A bone structure disease that has_material_basis_in displacement located_in set of vertebrae.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6682,,,,SNOMEDCT_US_2016_03_01:268349005|OMIM:184200|NCI:C35033|ICD10CM:M43.1|UMLS_CUI:C0038016|MESH:D013168|ICD10CM:M43.10|SNOMEDCT_US_2016_03_01:157003009|SNOMEDCT_US_2016_03_01:274152003,,,disease_ontology,,DOID:6682,,,,,,,,,,,,,,,,,,,spondylolisthesis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200807,"[""TAAR9 gene""]",,"A trace amine-associated receptor 9 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96RI9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A trace amine-associated receptor 9 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96RI9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200807,,,,,,,,,,,,,,,,134860,TAAR9,TA3|TAR3|TRAR3,,,,,,,,,,TAAR9 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000300,"[""SER280 in TGFBR1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29999,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000300,,,,,,,,,,,,,,,,,,,,,,,,,,,,SER280 in TGFBR1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002581,"[""MEG-01 cell""]",,Human chronic myeloid leukemia in megakaryocytic blast crisis established from the bone marrow of a 55-year-old man with chronic myeloid leukemia (CML) in megakaryocytic blast crisis in 1983.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002580,,,,,,,,Human chronic myeloid leukemia in megakaryocytic blast crisis established from the bone marrow of a 55-year-old man with chronic myeloid leukemia (CML) in megakaryocytic blast crisis in 1983.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002581,,,,,,,BrendaTissueOBO,,BTO:0002581,,,,,,,,,,,,,,,,,,,MEG-01 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200007,"[""ABL2 gene""]",,"This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400117,,,,,,,,"This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200007,,,,,,,,,,,,,,,,27,ABL2,ABLL|ARG,,,,,,,,,,ABL2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300452,"[""Polycystin subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300360,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300452,,,,,,,,,,,,,,,,,,,,,,,,,,,,Polycystin subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005112,"[""TRAMP-C1 cell""]",,This cell line was derived in 1996 from a heterogeneous 32 week primary tumor in the prostate of a PB-Tag C57BL/6 (TRAMP) mouse.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001033,,,,,,,,This cell line was derived in 1996 from a heterogeneous 32 week primary tumor in the prostate of a PB-Tag C57BL/6 (TRAMP) mouse.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005112,XPMUser,2011-05-05T10:17:21Z,,,,,BrendaTissueOBO,,BTO:0005112,,,,,,,,,,,,,,,,,,,TRAMP-C1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200232,"[""KCNQ1 gene""]",,"This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400561,,,,,,,,"This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200232,,,,,,,,,,,,,,,,3784,KCNQ1,KCNA8|KCNA9|KVLQT1,,,,,,,,,,KCNQ1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000212,"[""MET86 in TBK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000212,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET86 in TBK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400180,"[""SYK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400180,,,,,,,,,,,,,,,,,,,,,,,,,,,,SYK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000231,"[""MET96 in IKKB""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000231,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET96 in IKKB,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100527,"[""Olfactory receptor 2H1""]",,"An olfactory receptor 2H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZK4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZK4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100527,,,,https://pharos.nih.gov/idg/targets/Q9GZK4,,,,,,,,,,,,,OR2H1,OR2H6|OR2H8,,Q9GZK4,,,,,,,,Olfactory receptor 2H1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400595,"[""TRPV6 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400484,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400595,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPV6 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000416,"[""SRPK1 kinase domain""]",,SRSF protein kinase 1; SFRS protein kinase 1; Serine/arginine-rich protein-specific kinase 1; SFRSK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,SRSF protein kinase 1; SFRS protein kinase 1; Serine/arginine-rich protein-specific kinase 1; SFRSK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000416,,,,,,,,,,,,,,,,,,,200417,,,,,,,,,SRPK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200478,"[""SLK gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400315,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200478,,,,,,,,,,,,,,,,9748,SLK,KIAA0204|STK2,,,,,,,,,,SLK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4331,"[""burning mouth syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_403,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4331,,,,NCI:C62545|MESH:D002054|UMLS_CUI:C0006430|SNOMEDCT_US_2016_03_01:399165002|SNOMEDCT_US_2016_03_01:111349000,Orodynia|Stomatopyrosis,,disease_ontology,,DOID:4331,,,,,,,,,,,,,,,,,,,burning mouth syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004659,"[""exoskeleton""]",,"Exoskeleton or shell, including those of mollusks, turtles, insects and crustaceans.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000634,,,,,,,,"Exoskeleton or shell, including those of mollusks, turtles, insects and crustaceans.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004659,mgr,2010-05-05T09:24:54Z,,,,,BrendaTissueOBO,shell,BTO:0004659,,,,,,,,,,,,,,,,,,,exoskeleton,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200159,"[""KCNJ3 gene""]",,"Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, May 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400430,,,,,,,,"Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, May 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200159,,,,,,,,,,,,,,,,3760,KCNJ3,GIRK1,,,,,,,,,,KCNJ3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000165,"[""MET384 in EIF2AK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000165,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET384 in EIF2AK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300178,"[""RSK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300178,,,,,,,,,,,,,,,,,,,,,,,,,,,,RSK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200617,"[""OR5B21 gene""]",,"An olfactory receptor 5B21 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NL26] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5B21 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NL26] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200617,,,,,,,,,,,,,,,,219968,OR5B21,,,,,,,,,,,OR5B21 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000417,"[""VAL100 in YANK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000417,,,,,,,,,,,,,,,,,,,,,,,,,,,,VAL100 in YANK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200163,"[""GRK7 gene""]",,"This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400271,,,,,,,,"This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200163,,,,,,,,,,,,,,,,131890,GRK7,GPRK7,,,,,,,,,,GRK7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200302,"[""OR10G4 gene""]",,"An olfactory receptor 10G4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10G4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGN3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200302,,,,,,,,,,,,,,,,390264,OR10G4,,,,,,,,,,,OR10G4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_16044,"[""L-methionine residue""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_33700,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:16044,,,CHEBI:8535|CHEBI:29983|CHEBI:43924|CHEBI:14937,RESID:AA0013|KEGG:C03023|PDBeChem:MET_LL,L-methionine residue,,chebi_ontology,L-methionine|L-methionyl|C5H9NOS|Met|131.19710|131.040|-Met-|0|Protein L-methionine|M,CHEBI:16044,http://purl.obolibrary.org/obo/chebi#3_STAR,,,,,,,,,,,,,,,,,,L-methionine residue,,,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002404,"[""YMB-1 cell""]",,Human breast cancer cell line; established from a 55 year-old human female.,false,,,http://purl.obolibrary.org/obo/BTO_0004086|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human breast cancer cell line; established from a 55 year-old human female.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002404,,,,,,,BrendaTissueOBO,YMB1 cell,BTO:0002404,,,,,,,,,,,,,,,,,,,YMB-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100057,"[""Cyclin-dependent kinase 10""]",,"A cyclin-dependent kinase 10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15131] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391033,,,,,,,,"A cyclin-dependent kinase 10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15131] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100057,,,,https://pharos.nih.gov/idg/targets/Q15131,,,,,,,,,,,,,CDK10,,,Q15131,,,,,,,,Cyclin-dependent kinase 10,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200039,"[""ACVR2B gene""]",,"Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400252,,,,,,,,"Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200039,,,,,,,,,,,,,,,,93,ACVR2B,,,,,,,,,,,ACVR2B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100636,"[""Olfactory receptor 5M1""]",,"An olfactory receptor 5M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100636,,,,https://pharos.nih.gov/idg/targets/Q8NGP8,,,,,,,,,,,,,OR5M1,,,Q8NGP8,,,,,,,,Olfactory receptor 5M1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300045,"[""GABA-B receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300004,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300045,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABA-B receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4926,"[""bronchiolo-alveolar adenocarcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3910,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4926,,,,SNOMEDCT_US_2016_03_01:112677002|SNOMEDCT_US_2016_03_01:373627005|UMLS_CUI:C0007120|NCI:C2923|SNOMEDCT_US_2016_03_01:36310008|SNOMEDCT_US_2016_03_01:307595008|MESH:D002282,Bronchiolo-alveolar adenocarcinoma (morphologic abnormality)|Bronchioloalveolar adenocarcinoma|Alveolar adenocarcinoma (morphologic abnormality)|Bronchioloalveolar carcinoma (disorder)|Bronchioalveolar lung carcinoma,,disease_ontology,,DOID:4926,,,,,,,,,,,,,,,,,,,bronchiolo-alveolar adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200106,"[""FZD4 gene""]",,"A frizzled-4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9ULV1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400043,,,,,,,,"A frizzled-4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9ULV1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200106,,,,,,,,,,,,,,,,8322,FZD4,,,,,,,,,,,FZD4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400551,"[""Kv6.3/KCNG3 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400447,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400551,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv6.3/KCNG3 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300014,"[""Taste 2 receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300014,,,,,,,,,,,,,,,,,,,,,,,,,,,,Taste 2 receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000069,"[""LEU240 in SGK3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000069,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU240 in SGK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100351,"[""Olfactory receptor 14A2""]",,"An olfactory receptor 14A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R54] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 14A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R54] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100351,,,,https://pharos.nih.gov/idg/targets/Q96R54,,,,,,,,,,,,,OR14A2,OR5AX1|OR5AX1P,,Q96R54,,,,,,,,Olfactory receptor 14A2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200250,"[""MAS1L gene""]",,"A mas-related G-protein coupled receptor MRG that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35410] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400063,,,,,,,,"A mas-related G-protein coupled receptor MRG that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35410] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200250,,,,,,,,,,,,,,,,116511,MAS1L,MRG,,,,,,,,,,MAS1L gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300508,"[""GABRA3 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300508,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRA3 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200594,"[""NMRK1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200594,,,,,,,,,,,,,,,,,,,,,,,,,,,,NMRK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200545,"[""OR2T1 gene""]",,"An olfactory receptor 2T1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43869] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2T1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43869] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200545,,,,,,,,,,,,,,,,26696,OR2T1,,,,,,,,,,,OR2T1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200196,"[""JAK1 gene""]",,"Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein.  JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400167,,,,,,,,"Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein.  JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200196,,,,,,,,,,,,,,,,3716,JAK1,JAK1A|JAK1B,,,,,,,,,,JAK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_7633,"[""macular holes""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5679,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:7633,,,,NCI:C34795|SNOMEDCT_US_2016_03_01:232006002|UMLS_CUI:C0024441|MESH:D012167|SNOMEDCT_US_2016_03_01:193388002,Macular hole,,disease_ontology,,DOID:7633,,,,,,,,,,,,,,,,,,,macular holes,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100282,"[""Mitogen-activated protein kinase kinase kinase 19""]",,"A mitogen-activated protein kinase kinase kinase 19 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q56UN5] |mitogen-activated protein kinase kinase kinase 19 (YSK4)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300186,,,,,,,,"A mitogen-activated protein kinase kinase kinase 19 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q56UN5] |mitogen-activated protein kinase kinase kinase 19 (YSK4)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100282,,,,https://pharos.nih.gov/idg/targets/Q56UN5,,,,,,,,,,,,,MAP3K19,RCK|YSK4,,Q56UN5,,,,,,,,Mitogen-activated protein kinase kinase kinase 19,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300308,"[""PLK2 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300211,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300308,,,,,,,,,,,,,,,,,,,,,,,,,,,,PLK2 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200089,"[""CLK4 gene""]",,"The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400140,,,,,,,,"The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200089,,,,,,,,,,,,,,,,57396,CLK4,,,,,,,,,,,CLK4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13148,"[""acute cystitis""]",,A cystitis characterized by a sudden onset or severe symptoms.,false,,,http://purl.obolibrary.org/obo/DOID_1679,,,,,,,,A cystitis characterized by a sudden onset or severe symptoms.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13148,,,,UMLS_CUI:C0149523|SNOMEDCT_US_2016_03_01:197833009|ICD10CM:N30.0|SNOMEDCT_US_2016_03_01:155883005|ICD9CM:595.0|NCI:C26934|SNOMEDCT_US_2016_03_01:68226007|SNOMEDCT_US_2016_03_01:266628008,urinary tract infection,,disease_ontology,,DOID:13148,,,,,,,,,,,,,,,,,,,acute cystitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13141,"[""uveitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3480,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13141,,,,SNOMEDCT_US_2016_03_01:155116005|SNOMEDCT_US_2016_03_01:267719008|NCI:C26909|UMLS_CUI:C0042164|SNOMEDCT_US_2016_03_01:193499001|ICD10CM:H20.9|MESH:D014605|SNOMEDCT_US_2016_03_01:128473001|SNOMEDCT_US_2016_03_01:75614007,,,disease_ontology,,DOID:13141,,,,,,,,,,,,,,,,,,,uveitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000228,"[""C-1300 cell""]",,Mouse neuroblastoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000932,,,,,,,,Mouse neuroblastoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000228,,,,,,,BrendaTissueOBO,C1300 cell,BTO:0000228,,,,,,,,,,,,,,,,,,,C-1300 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100304,"[""Amiloride-sensitive sodium channel subunit beta""]",,"An amiloride-sensitive sodium channel subunit beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51168] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300478,,,,,,,,"An amiloride-sensitive sodium channel subunit beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51168] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100304,,,,https://pharos.nih.gov/idg/targets/P51168,,,,,,,,,,,,,SCNN1B,,,P51168,,,,,,,,Amiloride-sensitive sodium channel subunit beta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200255,"[""MCHR1 gene""]",,"A melanin-concentrating hormone receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99705] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400052,,,,,,,,"A melanin-concentrating hormone receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99705] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200255,,,,,,,,,,,,,,,,2847,MCHR1,GPR24|SLC1,,,,,,,,,,MCHR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400134,"[""BUB family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400134,,,,,,,,,,,,,,,,,,,,,,,,,,,,BUB family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200695,"[""OR8G2 gene""]",,"An olfactory receptor 8G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15614] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 8G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15614] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200695,,,,,,,,,,,,,,,,26492,OR8G2,OR8G2P|OR8G4,,,,,,,,,,OR8G2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000193,"[""IKKE kinase domain""]",,Inhibitor of nuclear factor kappa-B kinase subunit epsilon,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Inhibitor of nuclear factor kappa-B kinase subunit epsilon,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000193,,,,,,,,,,,,,,,,,,,200196,,,,,,,,,IKKE kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004726,"[""embryonic brain""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000142|http://purl.obolibrary.org/obo/UBERON_0000955,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004726,mgr,2010-08-20T08:29:57Z,,,,,BrendaTissueOBO,,BTO:0004726,,,,,,,,,,,,,,,,,,,embryonic brain,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000101,"[""CSNK1G3 kinase domain""]",,"Casein kinase 1, gamma 3; CK1g3; CSNK1G3",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Casein kinase 1, gamma 3; CK1g3; CSNK1G3",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000101,,,,,,,,,,,,,,,,,,,200102,,,,,,,,,CSNK1G3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004868,"[""anaplastic large cell lymphoma cell line""]",,"An aggressive (rapidly progressing) type of non-Hodgkins lymphoma that is usually of the T-cell type. The cancer cells express a marker called CD30 or Ki-1 on the surface, and may appear in the lymph nodes, skin, bones, soft tissues, lungs, or liver.",false,,,http://purl.obolibrary.org/obo/BTO_0000104|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"An aggressive (rapidly progressing) type of non-Hodgkins lymphoma that is usually of the T-cell type. The cancer cells express a marker called CD30 or Ki-1 on the surface, and may appear in the lymph nodes, skin, bones, soft tissues, lungs, or liver.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004868,mgr,2010-10-11T03:55:47Z,,,,,BrendaTissueOBO,ALCL cell line,BTO:0004868,,,,,,,,,,,,,,,,,,,anaplastic large cell lymphoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100419,"[""Olfactory receptor 52E6""]",,"An olfactory receptor 52E6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 52E6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100419,,,,https://pharos.nih.gov/idg/targets/Q96RD3,,,,,,,,,,,,,OR52E6,,,Q96RD3,,,,,,,,Olfactory receptor 52E6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000899,"[""myeloma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000583,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000899,,,,,,,BrendaTissueOBO,,BTO:0000899,,,,,,,,,,,,,,,,,,,myeloma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200759,"[""RXFP3 gene""]",,"A relaxin-3 receptor 1 that is encoded in the genome of human. [PRO:CNx, Reactome:REACT_21738] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A relaxin-3 receptor 1 that is encoded in the genome of human. [PRO:CNx, Reactome:REACT_21738] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200759,,,,,,,,,,,,,,,,51289,RXFP3,RLN3R1|SALPR,,,,,,,,,,RXFP3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000939,"[""basal cell""]",,One of the innermost cells of the deeper epidermis of the skin.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001470,,,,,,,,One of the innermost cells of the deeper epidermis of the skin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000939,,,,,,,BrendaTissueOBO,,BTO:0000939,,,,,,,,,,,,,,,,,,,basal cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200407,"[""PHKG2 gene""]",,"Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9C, also known as autosomal liver glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400205,,,,,,,,"Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9C, also known as autosomal liver glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200407,,,,,,,,,,,,,,,,5261,PHKG2,,,,,,,,,,,PHKG2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100609,"[""Nucleoside diphosphate kinase homolog 5""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100609,,,,,,,,,,,,,,,,,NME5,,,P56597,,,,,,,,Nucleoside diphosphate kinase homolog 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060388,"[""chromosomal deletion syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0080014,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060388,elvira,2015-09-28T15:48:41Z,,,,,disease_ontology,,DOID:0060388,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,chromosomal deletion syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3908,"[""non-small cell lung carcinoma""]",,A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.,false,,,http://purl.obolibrary.org/obo/DOID_3905,,,,,,,,A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3908,,,,SNOMEDCT_US_2016_03_01:254637007|UMLS_CUI:C0007131|KEGG:05223|NCI:C2926|MESH:D002289|EFO:0003060,NSCLC|Non-small cell lung cancer (disorder),,disease_ontology,,DOID:3908,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,non-small cell lung carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80290,"[""Humanin""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16068,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80290,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80290,,,,,Humanin,,CHEBI:80290,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002435,"[""colorectal mucosa""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0000642|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002435,,,,,,,BrendaTissueOBO,,BTO:0002435,,,,,,,,,,,,,,,,,,,colorectal mucosa,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1557,"[""hypersensitivity reaction type III disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060056,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1557,,,,UMLS_CUI:C0020951|MESH:D007105,immune complex disease,,disease_ontology,,DOID:1557,,,,,,,,,,,,,,,,,,,hypersensitivity reaction type III disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300151,"[""PEK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300151,,,,,,,,,,,,,,,,,,,,,,,,,,,,PEK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100061,"[""Cyclin-dependent kinase 15""]",,"cyclin-dependent kinase 15 (CDK15)  with  no mutation  in a nonphosphorylated state|A cyclin-dependent kinase 15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96Q40] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300256,,,,,,,,"cyclin-dependent kinase 15 (CDK15)  with  no mutation  in a nonphosphorylated state|A cyclin-dependent kinase 15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96Q40] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100061,,,,https://pharos.nih.gov/idg/targets/Q96Q40,,,,,,,,,,,,,CDK15,ALS2CR7|PFTK2,,Q96Q40,,,,,,,,Cyclin-dependent kinase 15,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300426,"[""KCNJ15 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300426,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ15 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1680,"[""chronic cystitis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1679,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1680,,,,SNOMEDCT_US_2016_03_01:197842002|SNOMEDCT_US_2016_03_01:197839008|ICD10CM:N30.2|UMLS_CUI:C0156268|ICD9CM:595.2|SNOMEDCT_US_2016_03_01:198536006,,,disease_ontology,,DOID:1680,,,,,,,,,,,,,,,,,,,chronic cystitis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200266,"[""LCK gene""]",,"This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400132,,,,,,,,"This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200266,,,,,,,,,,,,,,,,3932,LCK,,,,,,,,,,,LCK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100312,"[""Transmembrane channel-like protein 4""]",,"A transmembrane channel-like protein 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z404] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300372,,,,,,,,"A transmembrane channel-like protein 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z404] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100312,,,,https://pharos.nih.gov/idg/targets/Q7Z404,,,,,,,,,,,,,TMC4,,,Q7Z404,,,,,,,,Transmembrane channel-like protein 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300224,"[""SGK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300224,,,,,,,,,,,,,,,,,,,,,,,,,,,,SGK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001551,"[""free-living state""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000284,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001551,,,,,,,BrendaTissueOBO,,BTO:0001551,,,,,,,,,,,,,,,,,,,free-living state,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11504,"[""autonomic neuropathy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_11465,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11504,,,,UMLS_CUI:C0259749|CSP:2049-9000|SNOMEDCT_US_2016_03_01:277879009|CSP:2042-2001|NCI:C27033,,,disease_ontology,,DOID:11504,,,,,,,,,,,,,,,,,,,autonomic neuropathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11502,"[""mitral valve insufficiency""]",,,false,,,http://purl.obolibrary.org/obo/DOID_61,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11502,,,DOID:11737|DOID:13947,ICD10CM:Q23.3|UMLS_CUI:C0264774|SNOMEDCT_US_2016_03_01:29928006|MESH:D008944|ICD9CM:746.6|SNOMEDCT_US_2016_03_01:48724000|SNOMEDCT_US_2016_03_01:233857005|NCI:C50888|UMLS_CUI:C0158619|ICD9CM:396.3|UMLS_CUI:C0026266|SNOMEDCT_US_2016_03_01:194977007|SNOMEDCT_US_2016_03_01:194736003|NCI:C50852,congenital mitral regurgitation|congenital mitral insufficiency|Congenital insufficiency of mitral valve (disorder)|Mitral valve incompetence|mitral regurgitation,,disease_ontology,,DOID:11502,,,,,,,,,,,,,,,,,,,mitral valve insufficiency,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11503,"[""diabetic autonomic neuropathy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_9743|http://purl.obolibrary.org/obo/DOID_11504,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11503,,,,NCI:C27068|MESH:D003929|SNOMEDCT_US_2016_03_01:50620007|UMLS_CUI:C0271686,Diabetic autonomic neuropathy (disorder),,disease_ontology,,DOID:11503,,,,,,,,,,,,,,,,,,,diabetic autonomic neuropathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11506,"[""suppurative otitis media""]",,A otitis media which involves inflammation of the middle ear with infected effusion containing pus.,false,,,http://purl.obolibrary.org/obo/DOID_10754,,,,,,,,A otitis media which involves inflammation of the middle ear with infected effusion containing pus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11506,,,,SNOMEDCT_US_2016_03_01:267758003|ICD9CM:382|SNOMEDCT_US_2016_03_01:194258000|ICD9CM:382.4|UMLS_CUI:C0029888|ICD10CM:H66.4|SNOMEDCT_US_2016_03_01:194285007|ICD10CM:H66.40|SNOMEDCT_US_2016_03_01:155229002|MESH:D010035|SNOMEDCT_US_2016_03_01:39288006|ICD10CM:H66|SNOMEDCT_US_2016_03_01:38394007|SNOMEDCT_US_2016_03_01:194280002,Otitis media with effusion - purulent|Purulent otitis media,,disease_ontology,,DOID:11506,,,,,,,,,,,,,,,,,,,suppurative otitis media,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100060,"[""Y1156 in ALK(C1156Y)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100060,,,,,,,,,,,,,,,,,,,,,,,,,,,,Y1156 in ALK(C1156Y),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200231,"[""HRH2 gene""]",,"A histamine H2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25021] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400061,,,,,,,,"A histamine H2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25021] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200231,,,,,,,,,,,,,,,,3274,HRH2,,,,,,,,,,,HRH2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200276,"[""PKD1L2 gene""]",,"This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores. This gene appears to be a polymorphic pseudogene in humans, where some individuals contain a non-functional allele. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_01400367,,,,,,,,"This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores. This gene appears to be a polymorphic pseudogene in humans, where some individuals contain a non-functional allele. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200276,,,,,,,,,,,,,,,,114780,PKD1L2,KIAA1879|PC1L2,,,,,,,,,,PKD1L2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000342,"[""PIK3CA(C420R) kinase domain""]",,"Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000342,,,,,,,,,,,,,,,,,,,200324,,,,,,,,,PIK3CA(C420R) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400295,"[""Erk7 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400191,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400295,,,,,,,,,,,,,,,,,,,,,,,,,,,,Erk7 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4674,"[""androgen insensitivity syndrome""]",,"A sex differentiation disease that is characterized by the partial or complete inability of the cell to respond to androgens in individuals with a karyotype of 46,XY resulting in female physical traits but male genetic makeup.",false,,,http://purl.obolibrary.org/obo/DOID_1923,,,,,,,,"A sex differentiation disease that is characterized by the partial or complete inability of the cell to respond to androgens in individuals with a karyotype of 46,XY resulting in female physical traits but male genetic makeup.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4674,,,DOID:4672,NCI:C120191|ICD9CM:259.51|UMLS_CUI:C0039585|ICD9CM:259.5|ICD10CM:E34.50|OMIM:300068|UMLS_CUI:C0936016|SNOMEDCT_US_2016_03_01:190562003|ICD10CM:E34.51|SNOMEDCT_US_2016_03_01:12313004|SNOMEDCT_US_2016_03_01:154713003|NCI:C27226|MESH:D013734|SNOMEDCT_US_2016_03_01:237802009|SNOMEDCT_US_2016_03_01:368851000119102|SNOMEDCT_US_2016_03_01:267486007|SNOMEDCT_US_2016_03_01:52832001|ICD10CM:E34.5,testicular Feminization syndrome|testicular feminization (disorder)|Feminisation - testicular|Goldberg-Maxwell syndrome|Goldberg - Maxwell syndrome|Androgen resistance syndrome (disorder)|testicular feminization|Androgen-Insensitivity Syndrome,,disease_ontology,,DOID:4674,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,androgen insensitivity syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/UBERON_0002110,"[""gallbladder""]",vesica fellea; vesica biliaris,a small organ that aids digestion and stores bile produced by the liver[WP]. Organ with organ cavity which is continuous proximally with the cystic duct and distally terminates in the fundus of the gallbladder[FMA].,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062|http://purl.obolibrary.org/obo/BTO_0000123,,relationship type change: differentiates_from endoderm (AAO:0000139) CHANGED TO: develops_from endoderm (UBERON:0000925)[AAO],,,,,http://www.snomedbrowser.com/Codes/Details/181269000|http://en.wikipedia.org/wiki/Gallbladder|http://linkedlifedata.com/resource/umls/id/C0016976|MA:0000356|OpenCyc:Mx4rvVkGr5wpEbGdrcN5Y29ycA|MAT:0000072|ZFA:0000208|EMAPA:17202|CALOHA:TS-0394|EHDAA:8062|galen:Gallbladder|XAO:0000135|MESH:A03.159.439|BTO:0000493|EHDAA2:0000699|EFO:0000853|EV:0100090|AAO:0010114|TAO:0000208|MIAA:0000072|VHOG:0000221|FMA:7202|UMLS:C0016976|ncithesaurus:Gallbladder,a small organ that aids digestion and stores bile produced by the liver[WP]. Organ with organ cavity which is continuous proximally with the cystic duct and distally terminates in the fundus of the gallbladder[FMA].,,http://upload.wikimedia.org/wikipedia/commons/thumb/f/f4/Abdomal_organs.svg/200px-Abdomal_organs.svg.png|http://upload.wikimedia.org/wikipedia/commons/3/3f/Illu_pancrease.svg,,,,,,,,"Membranous muscular sac in which the bile from the liver remains stored until it is required. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]|Organ attached to the liver which stores bile and empties into the duodenum via the bile duct as needed for digestion.[AAO]",,,,,,,,,,,,,,,,,,,,,,,,,,gall bladder,,uberon,vesica fellea; vesica biliaris,,"The presence of a gallbladder appears to be a primitive trait. It is found in most fish and all adult reptiles and amphibians and has been well conserved in mammals, for the most part.[well established][VHOG]",,,,,,,,,,,,,,,,,,,,,,,,UBERON:0002110,,,"Rats do not have a gallbladder, but produce bile. The bile flows directly from the liver through the (hepatic) bile duct into the small intestine (Hebel and Stromberg, 1988)",,gallbladder,,UBERON:0002110,,http://purl.obolibrary.org/obo/uberon.owl,http://purl.obolibrary.org/obo/uberon/core#efo_slim|http://purl.obolibrary.org/obo/uberon/core#organ_slim|http://purl.obolibrary.org/obo/uberon/core#vertebrate_core|http://purl.obolibrary.org/obo/uberon/core#uberon_slim,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/UBERON_0002114,"[""duodenum""]",upper intestine|proximal intestine,"The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one).",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,http://en.wikipedia.org/wiki/Duodenum|http://linkedlifedata.com/resource/umls/id/C0013303|http://www.snomedbrowser.com/Codes/Details/181247007|OpenCyc:Mx4rv4LJDpwpEbGdrcN5Y29ycA|EV:0100073|BTO:0000365|MIAA:0000044|ncithesaurus:Duodenum|galen:Duodenum|UMLS:C0013303|AAO:0010402|FMA:7206|MESH:A03.492.411.620.270|XAO:0000236|VHOG:0000052|MA:0000338|GAID:284|EMAPA:18852|EFO:0000851|CALOHA:TS-0214|MAT:0000044,"The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one).",,http://upload.wikimedia.org/wikipedia/commons/b/b3/Tractus_intestinalis_duodenum.svg,,,http://purl.obolibrary.org/obo/NCBITaxon_7955,,,,,"The fixed portion of the small intestine deeply lodged in the posterior wall of the abdomen and extending from the pylorus to the beginning of the jejunum. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]",,,,,,,,,,,,,,,,,,,,,,,,,,,,uberon,upper intestine|proximal intestine,duodenal,,,,,,,,,,,,,,,,,,,,,,,,,UBERON:0002114,,,,,duodenum,,UBERON:0002114,,http://purl.obolibrary.org/obo/uberon.owl,http://purl.obolibrary.org/obo/uberon/core#efo_slim|http://purl.obolibrary.org/obo/uberon/core#vertebrate_core|http://purl.obolibrary.org/obo/uberon/core#uberon_slim,,,,,,,,,,,,,,,,,,,,,,"In fish, the divisions of the small intestine are not as clear, and the terms anterior intestine or proximal intestine may be used instead of duodenum.|In humans, the duodenum is a hollow jointed tube about 10–15 inches (25–38 centimetres) long connecting the stomach to the jejunum. It begins with the duodenal bulb and ends at the ligament of Treitz.",,
http://purl.obolibrary.org/obo/UBERON_0002113,"[""kidney""]",reniculate kidney,A paired organ which has the production of urine as its primary function.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001491|http://purl.obolibrary.org/obo/BTO_0000431|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,http://en.wikipedia.org/wiki/Kidney|http://www.snomedbrowser.com/Codes/Details/181414000|http://linkedlifedata.com/resource/umls/id/C0022646|GAID:423|AAO:0000250|BTO:0000671|FMA:7203|EV:0100096|EFO:0000929|ncithesaurus:Kidney|galen:Kidney|MAT:0000119|OpenCyc:Mx4rvVjlYpwpEbGdrcN5Y29ycA|CALOHA:TS-0510|XAO:0003267|MESH:A05.810.453|UMLS:C0022646|MA:0000368|MIAA:0000119,A paired organ which has the production of urine as its primary function.,,,,,,,,,,One of either of a pair of structures lying on either side of the dorsal aorta in which fluid balance is regulated and waste is excreted out in the form of urine.[AAO],http://purl.obolibrary.org/obo/FMA_264815,,,,,,,,,,,,,,,,,,,,,,,,,,reniculate kidney,uberon,,renal,,,,,,,,,,,,,,,,,,,,,,,,,UBERON:0002113,,,,,kidney,,UBERON:0002113,,http://purl.obolibrary.org/obo/uberon.owl,http://purl.obolibrary.org/obo/uberon/core#efo_slim|http://purl.obolibrary.org/obo/uberon/core#organ_slim|http://purl.obolibrary.org/obo/uberon/core#vertebrate_core|http://purl.obolibrary.org/obo/uberon/core#major_organ|http://purl.obolibrary.org/obo/uberon/core#uberon_slim,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200140,"[""GPR126 gene""]",,"A G-protein coupled receptor 126 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86SQ4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,"A G-protein coupled receptor 126 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86SQ4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200140,,,,,,,,,,,,,,,,57211,GPR126,DREG|VIGR,,,,,,,,,,GPR126 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200308,"[""MAST3 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400160,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200308,,,,,,,,,,,,,,,,23031,MAST3,KIAA0561,,,,,,,,,,MAST3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002639,"[""NS20Y cell""]",,Mouse neuroblastoma cell line established from a A/Jax mouse strain with neuroblastoma C1300. Cells were described to be aneuploid and to contain high specific activity of choline acetyltransferase.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000932,,,,,,,,Mouse neuroblastoma cell line established from a A/Jax mouse strain with neuroblastoma C1300. Cells were described to be aneuploid and to contain high specific activity of choline acetyltransferase.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002639,,,,,,,BrendaTissueOBO,NS-20Y cell|NS20-Y cell,BTO:0002639,,,,,,,,,,,,,,,,,,,NS20Y cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200394,"[""PDIK1L gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400202,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200394,,,,,,,,,,,,,,,,149420,PDIK1L,CLIK1L,,,,,,,,,,PDIK1L gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000392,"[""RPS6KA5(Kin.Dom.1-N-terminal) kinase domain""]",,"Ribosomal protein S6 kinase, 90kDa, polypeptide 5; MGC1911; MSK1; MSPK1; RLPK; RPS6KA5",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Ribosomal protein S6 kinase, 90kDa, polypeptide 5; MGC1911; MSK1; MSPK1; RLPK; RPS6KA5",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000392,,,,,,,,,,,,,,,,,,,"200393, 200394",,,,,,,,,RPS6KA5(Kin.Dom.1-N-terminal) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200335,"[""TRPV3 gene""]",,"This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400592,,,,,,,,"This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200335,,,,,,,,,,,,,,,,162514,TRPV3,,,,,,,,,,,TRPV3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000375,"[""THR670 in KIT(V559D,V654A)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000375,,,,,,,,,,,,,,,,,,,,,,,,,,,,"THR670 in KIT(V559D,V654A)",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000412,"[""THR96 in SIK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000412,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR96 in SIK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200012,"[""ACVR1 gene""]",,"Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400246,,,,,,,,"Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200012,,,,,,,,,,,,,,,,90,ACVR1,ACVRLK2,,,,,,,,,,ACVR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1787,"[""pericarditis""]",,A pericardium disease that is characterized by an inflammation of the pericardium and has_symptom chest pain.,false,,,http://purl.obolibrary.org/obo/DOID_0050829,,,,,,,,A pericardium disease that is characterized by an inflammation of the pericardium and has_symptom chest pain.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1787,,,,SNOMEDCT_US_2016_03_01:3238004|NCI:C34915|UMLS_CUI:C0031046|MESH:D010493,,,disease_ontology,,DOID:1787,,,,,,,,,,,,,,,,,,,pericarditis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001949,"[""HUVEC cell""]",,"A convenient source of human endothelial cells are those that line the large vein in the umbilical cord which is usually discarded together with the placenta after childbirth. The cells can be removed as a fairly pure suspension by mild enzymatic treatment of the vein followed by some mechanical distraction and will grow relatively easily in culture, retaining their differentiated characteristics for several passages.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001520,,,,,,,,"A convenient source of human endothelial cells are those that line the large vein in the umbilical cord which is usually discarded together with the placenta after childbirth. The cells can be removed as a fairly pure suspension by mild enzymatic treatment of the vein followed by some mechanical distraction and will grow relatively easily in culture, retaining their differentiated characteristics for several passages.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001949,,,,,,,BrendaTissueOBO,human umbilical vein endothelial cell|HUVEC,BTO:0001949,,,,,,,,,,,,,,,,,,,HUVEC cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100150,"[""Fibroblast growth factor receptor 2""]",,"fibroblast growth factor receptor 2 (FGFR2)  with  no mutation  in a nonphosphorylated state|A fibroblast growth factor receptor 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P21802] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300158,,,,,,,,"fibroblast growth factor receptor 2 (FGFR2)  with  no mutation  in a nonphosphorylated state|A fibroblast growth factor receptor 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P21802] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100150,,,,https://pharos.nih.gov/idg/targets/P21802,,,,,,,,,,,,,FGFR2,BEK|KGFR|KSAM,,P21802,,,,,,,,Fibroblast growth factor receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300576,"[""MCOLN3 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300452,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300576,,,,,,,,,,,,,,,,,,,,,,,,,,,,MCOLN3 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200809,"[""TRHR gene""]",,"A thyrotropin-releasing hormone receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P34981] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A thyrotropin-releasing hormone receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P34981] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200809,,,,,,,,,,,,,,,,7201,TRHR,,,,,,,,,,,TRHR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00102000,"[""Nuclear hormone receptor""]",,"Nuclear hormone receptor proteins form a class of ligand activated proteins that, when bound to specific sequences of DNA serve as on-off switches for transcription within the cell nucleus. These switches control the development and differentiation of skin, bone and behavioral centers in the brain, as well as the continual regulation of reproductive tissues.",false,,,http://purl.obolibrary.org/obo/PR_000000001,,,,,,,,"Nuclear hormone receptor proteins form a class of ligand activated proteins that, when bound to specific sequences of DNA serve as on-off switches for transcription within the cell nucleus. These switches control the development and differentiation of skin, bone and behavioral centers in the brain, as well as the continual regulation of reproductive tissues.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00102000,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.ks.uiuc.edu/Research/pro_DNA/ster_horm_rec/,Nuclear hormone receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200047,"[""BRAF gene""]",,"This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400126,,,,,,,,"This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200047,,,,,,,,,,,,,,,,673,BRAF,BRAF1|RAFB1,,,,,,,,,,BRAF gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200142,"[""GRIK4 gene""]",,"This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_01400419,,,,,,,,"This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200142,,,,,,,,,,,,,,,,2900,GRIK4,GRIK,,,,,,,,,,GRIK4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000183,"[""CCL7""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000183,,,,,,,,,,,,,,,,,,,,,,,,,,,,CCL7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100015,"[""Neuronal acetylcholine receptor subunit beta-2""]",,"A neuronal acetylcholine receptor subunit beta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P17787] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300499,,,,,,,,"A neuronal acetylcholine receptor subunit beta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P17787] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100015,,,,https://pharos.nih.gov/idg/targets/P17787,,,,,,,,,,,,,CHRNB2,,,P17787,,,,,,,,Neuronal acetylcholine receptor subunit beta-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300225,"[""SGK071 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300225,,,,,,,,,,,,,,,,,,,,,,,,,,,,SGK071 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000096,"[""CSK kinase domain""]",,C-src tyrosine kinase; CSK; MGC117393,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,C-src tyrosine kinase; CSK; MGC117393,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000096,,,,,,,,,,,,,,,,,,,200095,,,,,,,,,CSK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300025,"[""Bradykinin receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300025,,,,,,,,,,,,,,,,,,,,,,,,,,,,Bradykinin receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200433,"[""OR52N5 gene""]",,"An olfactory receptor 52N5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH56] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 52N5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH56] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200433,,,,,,,,,,,,,,,,390075,OR52N5,,,,,,,,,,,OR52N5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100815,"[""Vasopressin v1a receptor""]",,"A vasopressin V1a receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P37288] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A vasopressin V1a receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P37288] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100815,,,,https://pharos.nih.gov/idg/targets/P37288,,,,,,,,,,,,,AVPR1A,AVPR1,,P37288,,,,,,,,Vasopressin v1a receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200322,"[""MAPK10 gene""]",,"The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400293,,,,,,,,"The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200322,,,,,,,,,,,,,,,,5602,MAPK10,JNK3|JNK3A|PRKM10,,,,,,,,,,MAPK10 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200274,"[""LTK gene""]",,"The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400122,,,,,,,,"The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200274,,,,,,,,,,,,,,,,4058,LTK,TYK1,,,,,,,,,,LTK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200772,"[""SSTR3 gene""]",,"A somatostatin receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32745] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A somatostatin receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32745] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200772,,,,,,,,,,,,,,,,6753,SSTR3,,,,,,,,,,,SSTR3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000283,"[""MLK2 kinase domain""]",,Mitogen-activated protein kinase kinase kinase 10; MAP3K10; MEKK10; MLK2; MST,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase kinase kinase 10; MAP3K10; MEKK10; MLK2; MST,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000283,,,,,,,,,,,,,,,,,,,200268,,,,,,,,,MLK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003953,"[""endomesoderm""]",,An embryonic blastomere or cell layer not yet differentiated into mesoderm and endoderm but destined to give rise to both.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000556|http://purl.obolibrary.org/obo/BTO_0001473,,,,,,,,An embryonic blastomere or cell layer not yet differentiated into mesoderm and endoderm but destined to give rise to both.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003953,,,,,,,BrendaTissueOBO,mesendoderm,BTO:0003953,,,,,,,,,,,,,,,,,,,endomesoderm,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000416,"[""VAL100 in YANK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000416,,,,,,,,,,,,,,,,,,,,,,,,,,,,VAL100 in YANK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300504,"[""Epsilon/CHRNE sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300504,,,,,,,,,,,,,,,,,,,,,,,,,,,,Epsilon/CHRNE sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200385,"[""PAK2 gene""]",,"The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400303,,,,,,,,"The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200385,,,,,,,,,,,,,,,,5062,PAK2,,,,,,,,,,,PAK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001981,"[""sebum""]",,Fatty lubricant matter secreted by sebaceous glands of the skin.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Fatty lubricant matter secreted by sebaceous glands of the skin.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001981,,,,,,,BrendaTissueOBO,,BTO:0001981,,,,,,,,,,,,,,,,,,,sebum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000743,"[""pre-B-lymphocyte cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000743,,,,,,,BrendaTissueOBO,pre-B-cell line,BTO:0000743,,,,,,,,,,,,,,,,,,,pre-B-lymphocyte cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1063,"[""interstitial nephritis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_10952,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1063,,,,MESH:D009395|SNOMEDCT_US_2016_03_01:28689008|NCI:C26834|UMLS_CUI:C0027707|SNOMEDCT_US_2016_03_01:264536006|ICD10CM:N12,renal tubulo-interstitial disease,,disease_ontology,,DOID:1063,,,,,,,,,,,,,,,,,,,interstitial nephritis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10632,"[""Wolfram syndrome""]",,"An autosomal recessive disease that is characterized by diabetes mellitus, optic atrophy, and deafness as well as various other possible disorders and has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the gene encoding wolframin (WFS1).",false,,,http://purl.obolibrary.org/obo/DOID_0050737,,,,,,,,"An autosomal recessive disease that is characterized by diabetes mellitus, optic atrophy, and deafness as well as various other possible disorders and has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the gene encoding wolframin (WFS1).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10632,,,,MESH:D014929|UMLS_CUI:C0043207|SNOMEDCT_US_2016_03_01:70694009|NCI:C35133,Diabetes mellitus AND insipidus with optic atrophy AND deafness (disorder)|DIDMOAD|WFS,,disease_ontology,,DOID:10632,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,Wolfram syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100455,"[""2-5a-dependent ribonuclease""]",,"A 2-5A-dependent ribonuclease that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q05823] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300218,,,,,,,,"A 2-5A-dependent ribonuclease that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q05823] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100455,,,,https://pharos.nih.gov/idg/targets/Q05823,,,,,,,,,,,,,RNASEL,RNS4,,Q05823,,,,,,,,2-5a-dependent ribonuclease,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_15555,"[""prostaglandin D2""]","
(5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate
|
(5Z,13E,15S)-9a,15-dihydroxy-11-oxoprosta-5,13-dien-1-oate
|
(5Z,9-alpha,13E,15S)-9,15-dihydroxy-11-oxo-Prosta-5,13-dien-1-oate
|9S,15S-Dihydroxy-11-oxo-5Z,13E-prostadienoate|
(5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoic acid
|PGD2|9S,15S-Dihydroxy-11-oxo-5Z,13E-prostadienoic acid|
(5Z)-7-[(1R,2R,5S)-5-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-3-oxocyclopentyl]hept-5-enoic acid
|
(5z,13e)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoic acid
|
(5Z,13E,15S)-9a,15-dihydroxy-11-oxoprosta-5,13-dien-1-oic acid
|
(5Z,13E)-(15S)-9a,15-Dihydroxy-11-oxoprosta-5,13-dienoate
|
(5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoic acid
|
(5Z,13E)-(15S)-9,15-dihydroxy-11-oxoprosta-5,13-dienoic acid
|
InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1
|
(5Z,13E)-(15S)-9,15-dihydroxy-11-oxoprosta-5,13-dienoate
|
(5Z,9alpha,13E,15S)-9,15-dihydroxy-11-oxo-prosta-5,13-dien-1-oic acid
|
(5Z,13E)-(15S)-9a,15-Dihydroxy-11-oxoprosta-5,13-dienoic acid
|
(5Z,9alpha,13E,15S)-9,15-dihydroxy-11-oxo-prosta-5,13-dien-1-oate
|
(5Z,13E,15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate
|C20H32O5|
CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)[C@@H](O)CC1=O
|11-Dehydroprostaglandin F2-alpha|
(5Z,9-alpha,13E,15S)-9,15-dihydroxy-11-oxo-Prosta-5,13-dien-1-oic acid
|11-Dehydroprostaglandin F2alpha|
(5z,13e)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
|
(5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
|BHMBVRSPMRCCGG-OUTUXVNYSA-N","
A member of the class of prostaglandins D that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9 and 15 and an oxo group at position 11 (the 5Z,9alpha,13E,15S- stereoisomer).
",false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,CiteXplore:15843042|PDBeChem:PG2|CiteXplore:3002327|CiteXplore:16289250|CiteXplore:806102|CiteXplore:24447364|CiteXplore:8182221|CiteXplore:7712673|CiteXplore:20671299|CiteXplore:2526527|DrugBank:DB02056|CiteXplore:9836493|CiteXplore:24456221|CiteXplore:24298012|KEGG COMPOUND:41598-07-6|CiteXplore:3462506|CiteXplore:11423836|HMDB:HMDB01403|ChemIDplus:41598-07-6|CiteXplore:12148545|CiteXplore:3139758|CiteXplore:6809826|CiteXplore:8757220|Wikipedia:Prostaglandin D2|CiteXplore:7979442|KEGG COMPOUND:C00696|Wikipedia:Prostaglandin_D2|CiteXplore:3862115|CiteXplore:1373750|CiteXplore:6430299|CiteXplore:2723663|Reaxys:2170623|LIPID MAPS:LMFA03010004|CiteXplore:380688|CiteXplore:3890960|CiteXplore:2835791|MetaCyc:5Z13E-15S-9-ALPHA15-DIHYDROXY-11-O|CiteXplore:3511806,"
A member of the class of prostaglandins D that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9 and 15 and an oxo group at position 11 (the 5Z,9alpha,13E,15S- stereoisomer).
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:10916|CHEBI:246|CHEBI:45044|CHEBI:26321,,"Prostaglandin D2|
(5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dien-1-oic acid
",,chebi_ontology,"
(5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate
|
(5Z,13E,15S)-9a,15-dihydroxy-11-oxoprosta-5,13-dien-1-oate
|
(5Z,9-alpha,13E,15S)-9,15-dihydroxy-11-oxo-Prosta-5,13-dien-1-oate
|9S,15S-Dihydroxy-11-oxo-5Z,13E-prostadienoate|
(5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoic acid
|PGD2|9S,15S-Dihydroxy-11-oxo-5Z,13E-prostadienoic acid|
(5Z)-7-[(1R,2R,5S)-5-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-3-oxocyclopentyl]hept-5-enoic acid
|
(5z,13e)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoic acid
|
(5Z,13E,15S)-9a,15-dihydroxy-11-oxoprosta-5,13-dien-1-oic acid
|
(5Z,13E)-(15S)-9a,15-Dihydroxy-11-oxoprosta-5,13-dienoate
|
(5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoic acid
|
(5Z,13E)-(15S)-9,15-dihydroxy-11-oxoprosta-5,13-dienoic acid
|
InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1
|
(5Z,13E)-(15S)-9,15-dihydroxy-11-oxoprosta-5,13-dienoate
|
(5Z,9alpha,13E,15S)-9,15-dihydroxy-11-oxo-prosta-5,13-dien-1-oic acid
|
(5Z,13E)-(15S)-9a,15-Dihydroxy-11-oxoprosta-5,13-dienoic acid
|
(5Z,9alpha,13E,15S)-9,15-dihydroxy-11-oxo-prosta-5,13-dien-1-oate
|
(5Z,13E,15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate
|C20H32O5|
CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)[C@@H](O)CC1=O
|11-Dehydroprostaglandin F2-alpha|
(5Z,9-alpha,13E,15S)-9,15-dihydroxy-11-oxo-Prosta-5,13-dien-1-oic acid
|11-Dehydroprostaglandin F2alpha|
(5z,13e)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
|
(5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
|BHMBVRSPMRCCGG-OUTUXVNYSA-N",,,CHEBI:15555,,,,,,,,,,,,,,,,,,,,,,,CHEBI:15555,,,,,PGD2|prostaglandin D2,,CHEBI:15555,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000328,"[""THR315 in ABL1(F317I)-phosphorylated""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000328,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR315 in ABL1(F317I)-phosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400335,"[""Calcium homeostasis modulator calcium channel (calhm-c) family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400335,,,,,,,,,,,,,,,,,,,,,,,,,,,,Calcium homeostasis modulator calcium channel (calhm-c) family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100210,"[""Potassium voltage-gated channel subfamily H member 6""]",,"A voltage-gated potassium channel KCNH6 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9H252] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300558,,,,,,,,"A voltage-gated potassium channel KCNH6 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9H252] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100210,,,,https://pharos.nih.gov/idg/targets/Q9H252,,,,,,,,,,,,,KCNH6,ERG2,,Q9H252,,,,,,,,Potassium voltage-gated channel subfamily H member 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005180,"[""pterygium""]",,A fleshy mass of thickened conjunctiva that grows over part of the cornea usually from the inner side of the eyeball and causes a disturbance of vision.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A fleshy mass of thickened conjunctiva that grows over part of the cornea usually from the inner side of the eyeball and causes a disturbance of vision.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005180,XPMUser,2011-08-30T01:02:10Z,,,,,BrendaTissueOBO,,BTO:0005180,,,,,,,,,,,,,,,,,,,pterygium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100472,"[""Serine/threonine-protein kinase sgk2""]",,"A serine/threonine-protein kinase Sgk2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HBY8] |serine/threonine-protein kinase sgk2 (SGK2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300224,,,,,,,,"A serine/threonine-protein kinase Sgk2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HBY8] |serine/threonine-protein kinase sgk2 (SGK2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100472,,,,https://pharos.nih.gov/idg/targets/Q9HBY8,,,,,,,,,,,,,SGK2,,,Q9HBY8,,,,,,,,Serine/threonine-protein kinase sgk2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400169,"[""PKA family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400169,,,,,,,,,,,,,,,,,,,,,,,,,,,,PKA family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000358,"[""PIP5K1A kinase domain""]",,"Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha; PIP5K1A",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha; PIP5K1A",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000358,,,,,,,,,,,,,,,,,,,200340,,,,,,,,,PIP5K1A kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003673,"[""nephrotome""]",,The modified part of a somite of a vertebrate embryo that develops into a segmental excretory tubule of the primitive kidney.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The modified part of a somite of a vertebrate embryo that develops into a segmental excretory tubule of the primitive kidney.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003673,,,,,,,BrendaTissueOBO,intermediate cell mass,BTO:0003673,,,,,,,,,,,,,,,,,,,nephrotome,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300546,"[""Kv4.2/KCND2 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300444,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300546,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv4.2/KCND2 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001966,"[""cervical cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001966,,,,,,,BrendaTissueOBO,,BTO:0001966,,,,,,,,,,,,,,,,,,,cervical cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000236,"[""MET99 in MST2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000236,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET99 in MST2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003744,"[""liposarcoma cell line""]",,"Cell line of a malignant tumor that arises in fat cells in deep soft tissue, such as that inside the thigh. Most frequent in middle-aged and older adults (age 40 and above), liposarcomas are the most common of all soft-tissue sarcomas.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000400,,,,,,,,"Cell line of a malignant tumor that arises in fat cells in deep soft tissue, such as that inside the thigh. Most frequent in middle-aged and older adults (age 40 and above), liposarcomas are the most common of all soft-tissue sarcomas.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003744,,,,,,,BrendaTissueOBO,,BTO:0003744,,,,,,,,,,,,,,,,,,,liposarcoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100605,"[""NAD kinase""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100605,,,,,,,,,,,,,,,,,NADK,,,O95544,,,,,,,,NAD kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000250,"[""MAK kinase domain""]",,Male germ cell-associated kinase; dJ417M14.2; MAK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Male germ cell-associated kinase; dJ417M14.2; MAK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000250,,,,,,,,,,,,,,,,,,,200234,,,,,,,,,MAK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000491,"[""excretion""]",,"The matter, such as urine or sweat, that is excreted from the blood, tissues, or organs.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The matter, such as urine or sweat, that is excreted from the blood, tissues, or organs.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000491,,,,,,,BrendaTissueOBO,,BTO:0000491,,,,,,,,,,,,,,,,,,,excretion,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100362,"[""Serine/threonine-protein kinase nek8""]",,"A serine/threonine-protein kinase Nek8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86SG6] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300197,,,,,,,,"A serine/threonine-protein kinase Nek8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86SG6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100362,,,,https://pharos.nih.gov/idg/targets/Q86SG6,,,,,,,,,,,,,NEK8,JCK|NEK12A,,Q86SG6,,,,,,,,Serine/threonine-protein kinase nek8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000896,"[""bag cell neuron""]",,"Cluster of electrically coupled neurons in the abdominal ganglion of Aplysia that are homogeneous, easily dissected out and release peptides that stimulate egg laying.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Cluster of electrically coupled neurons in the abdominal ganglion of Aplysia that are homogeneous, easily dissected out and release peptides that stimulate egg laying.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000896,,,,,,,BrendaTissueOBO,,BTO:0000896,,,,,,,,,,,,,,,,,,,bag cell neuron,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000403,"[""THR790 in EGFR(L861Q)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000403,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR790 in EGFR(L861Q),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000241,"[""PHE113 in CSNK2A1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000241,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE113 in CSNK2A1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000286,"[""MP2K1 kinase domain""]",,Dual specificity mitogen-activated protein kinase kinase 1; mitogen-activated protein kinase kinase 1; MAP2K1; MAPKK1; MEK1; MEK1/MAP2K1; MKK1; PRKMK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Dual specificity mitogen-activated protein kinase kinase 1; mitogen-activated protein kinase kinase 1; MAP2K1; MAPKK1; MEK1; MEK1/MAP2K1; MKK1; PRKMK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000286,,,,,,,,,,,,,,,,,,,200251,,,,,,,,,MP2K1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100033,"[""Beta-1 adrenergic receptor""]",,"A beta-1 adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08588] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300094,,,,,,,,"A beta-1 adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08588] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100033,,,,https://pharos.nih.gov/idg/targets/P08588,,,,,,,,,,,,,ADRB1,ADRB1R|B1AR,,P08588,,,,,,,,Beta-1 adrenergic receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000126,"[""MET1419 in MAP3K4""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000126,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET1419 in MAP3K4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000335,"[""PGFRB kinase domain""]",,"Platelet-derived growth factor receptor, beta polypeptide; CD140B; JTK12; PDGFR; PDGFR1; PDGFRB; PDGFR-b; PDGFRbeta; PEGFR-beta",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Platelet-derived growth factor receptor, beta polypeptide; CD140B; JTK12; PDGFR; PDGFR1; PDGFRB; PDGFR-b; PDGFRbeta; PEGFR-beta",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000335,,,,,,,,,,,,,,,,,,,200313,,,,,,,,,PGFRB kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000239,"[""LRRK2 kinase domain""]",,Leucine-rich repeat serine/threonine-protein kinase 2; AURA17; DARDARIN; LRRK2; PARK8; RIPK7; ROCO2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Leucine-rich repeat serine/threonine-protein kinase 2; AURA17; DARDARIN; LRRK2; PARK8; RIPK7; ROCO2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000239,,,,,,,,,,,,,,,,,,,200229,,,,,,,,,LRRK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000913,"[""nasal polyp""]",,"Focal accumulations of edema fluid in the mucosa of the nose, with hyperplasia of the associated submucosal connective tissue.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Focal accumulations of edema fluid in the mucosa of the nose, with hyperplasia of the associated submucosal connective tissue.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000913,,,,,,,BrendaTissueOBO,,BTO:0000913,,,,,,,,,,,,,,,,,,,nasal polyp,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100454,"[""Rhodopsin kinase""]",,"A rhodopsin kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15835] |rhodopsin kinase (GRK1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300271,,,,,,,,"A rhodopsin kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15835] |rhodopsin kinase (GRK1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100454,,,,https://pharos.nih.gov/idg/targets/Q15835,,,,,,,,,,,,,GRK1,RHOK,,Q15835,,,,,,,,Rhodopsin kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100460,"[""Tyrosine-protein kinase transmembrane receptor ror2""]",,"A tyrosine-protein kinase transmembrane receptor ROR2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q01974] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300219,,,,,,,,"A tyrosine-protein kinase transmembrane receptor ROR2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q01974] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100460,,,,https://pharos.nih.gov/idg/targets/Q01974,,,,,,,,,,,,,ROR2,NTRKR2,,Q01974,,,,,,,,Tyrosine-protein kinase transmembrane receptor ror2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000245,"[""M3K2 kinase domain""]",,Mitogen-activated protein kinase kinase kinase 2; MAP3K2; MEKK2; MEKK2/MAP3K2; MEKK2B,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase kinase kinase 2; MAP3K2; MEKK2; MEKK2/MAP3K2; MEKK2B,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000245,,,,,,,,,,,,,,,,,,,200237,,,,,,,,,M3K2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000004,"[""ABL1(E255K) kinase domain""]",,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000004,,,,,,,,,,,,,,,,,,,200003,,,,,,,,,ABL1(E255K) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002600,"[""astrocyte cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0001531|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002600,,,,,,,BrendaTissueOBO,,BTO:0002600,,,,,,,,,,,,,,,,,,,astrocyte cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200601,"[""OR4N2 gene""]",,"An olfactory receptor 4N2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4N2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200601,,,,,,,,,,,,,,,,390429,OR4N2,,,,,,,,,,,OR4N2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200157,"[""PIKFYVE gene""]",,"Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400323,,,,,,,,"Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200157,,,,,,,,,,,,,,,,200576,PIKFYVE,KIAA0981|PIP5K3,,,,,,,,,,PIKFYVE gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400324,"[""Other small molecule kinase gene""]",,"Other small molecule kinase is a kinase enzyme that catalyzes the phosphorylation of a small molecule substrate other than a carbohydrate, nucleoside, nucleotide, lipid, etc.",false,,,http://www.drugtargetontology.org/dto/DTO_03400103,,,,,,,,"Other small molecule kinase is a kinase enzyme that catalyzes the phosphorylation of a small molecule substrate other than a carbohydrate, nucleoside, nucleotide, lipid, etc.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400324,,,,,,,,,,,,,,,,,,,,,,,,,,,,Other small molecule kinase gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300262,"[""CDK7 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300136,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300262,,,,,,,,,,,,,,,,,,,,,,,,,,,,CDK7 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117471,"[""Coup-tf-like receptors""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00102000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117471,,,,,,,,,,,,,,,,,,,,,,,,,,,,Coup-tf-like receptors,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000620,"[""ileum""]",,The last division of the small intestine extending between the jejunum and large intestine.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The last division of the small intestine extending between the jejunum and large intestine.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000620,,,,,,,BrendaTissueOBO,distal intestine|posterior intestine|intestinum ileum|lower intestine,BTO:0000620,,,,,,,,,,,,,,,,,,,ileum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100781,"[""Taste receptor type 2 member 20""]",,"A taste receptor type 2 member 20 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59543] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300014,,,,,,,,"A taste receptor type 2 member 20 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59543] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100781,,,,https://pharos.nih.gov/idg/targets/P59543,,,,,,,,,,,,,TAS2R20,TAS2R49,,P59543,,,,,,,,Taste receptor type 2 member 20,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000397,"[""RSK2(Kin.Dom.2-C-terminal) kinase domain""]",,Ribosomal protein S6 kinase alpha 3; KS6A3; S6K-alpha-3; p90-RSK 3; MAPKAPK-1b; pp90RSK2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Ribosomal protein S6 kinase alpha 3; KS6A3; S6K-alpha-3; p90-RSK 3; MAPKAPK-1b; pp90RSK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000397,,,,,,,,,,,,,,,,,,,200475,,,,,,,,,RSK2(Kin.Dom.2-C-terminal) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3081,"[""cystic lymphangioma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1475,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3081,,,,SNOMEDCT_US_2016_03_01:40225001|UMLS_CUI:C0206620|SNOMEDCT_US_2016_03_01:399882002|MESH:D018191|SNOMEDCT_US_2016_03_01:423984004|NCI:C3724,cystic Hygroma,,disease_ontology,,DOID:3081,,,,,,,,,,,,,,,,,,,cystic lymphangioma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002101,"[""multiple myeloma cell""]",,A malignant proliferation of plasma cells in bone marrow causing numerous tumors and characterized by the presence of abnormal proteins in the blood.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000898,,,,,,,,A malignant proliferation of plasma cells in bone marrow causing numerous tumors and characterized by the presence of abnormal proteins in the blood.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002101,,,,,,,BrendaTissueOBO,plasma cell myeloma cell,BTO:0002101,,,,,,,,,,,,,,,,,,,multiple myeloma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000716,"[""pancreatic beta cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000716,,,,,,,BrendaTissueOBO,,BTO:0000716,,,,,,,,,,,,,,,,,,,pancreatic beta cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000111,"[""MET126 in AAK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000111,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET126 in AAK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400015,"[""Taste 1 receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400004,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400015,,,,,,,,,,,,,,,,,,,,,,,,,,,,Taste 1 receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100320,"[""Mitogen-activated protein kinase 8""]",,"A mitogen-activated protein kinase 8 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P45983] |mitogen-activated protein kinase 8 (JNK1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300293,,,,,,,,"A mitogen-activated protein kinase 8 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P45983] |mitogen-activated protein kinase 8 (JNK1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100320,,,,https://pharos.nih.gov/idg/targets/P45983,,,,,,,,,,,,,MAPK8,JNK1|PRKM8|SAPK1|SAPK1C,,P45983,,,,,,,,Mitogen-activated protein kinase 8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001464,"[""wing disc""]",,"The entire dorsal mesothoracic disc (wing, notal, and pleural parts), in the larval stage of Drosophila.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The entire dorsal mesothoracic disc (wing, notal, and pleural parts), in the larval stage of Drosophila.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001464,,,,,,,BrendaTissueOBO,wing imaginal disc,BTO:0001464,,,,,,,,,,,,,,,,,,,wing disc,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000454,"[""ULK3 kinase domain""]",,Serine/threonine-protein kinase ULK3; Unc-51-like kinase 3 (C. elegans); DKFZp434C131; FLJ90566; ULK3,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase ULK3; Unc-51-like kinase 3 (C. elegans); DKFZp434C131; FLJ90566; ULK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000454,,,,,,,,,,,,,,,,,,,200457,,,,,,,,,ULK3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200604,"[""FN3KRP gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200604,,,,,,,,,,,,,,,,,,,,,,,,,,,,FN3KRP gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200448,"[""RIOK2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400311,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200448,,,,,,,,,,,,,,,,55781,RIOK2,,,,,,,,,,,RIOK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100067,"[""Calcium-activated chloride channel regulator family member 3""]",,"A calcium-activated chloride channel regulator family member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y6N3] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300339,,,,,,,,"A calcium-activated chloride channel regulator family member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y6N3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100067,,,,https://pharos.nih.gov/idg/targets/Q9Y6N3,,,,,,,,,,,,,CLCA3P,CLCA3,,Q9Y6N3,,,,,,,,Calcium-activated chloride channel regulator family member 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217556,"[""NR2E1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00217470,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217556,,,,,,,,,,,,,,,,7101,NR2E1,TLX,,,,,,,,,,NR2E1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003680,"[""Mo-B cell""]",,Human Caucasian peripheral blood hairy cell leukaemia B-lymphoblast cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0003681,,,,,,,,Human Caucasian peripheral blood hairy cell leukaemia B-lymphoblast cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003680,,,,,,,BrendaTissueOBO,Mo B cell,BTO:0003680,,,,,,,,,,,,,,,,,,,Mo-B cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400409,"[""Glycine receptor subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400328,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400409,,,,,,,,,,,,,,,,,,,,,,,,,,,,Glycine receptor subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004991,"[""UM-UC-14 cell""]",,Human transitional cell carcinoma of the renal pelvis.,false,,,http://purl.obolibrary.org/obo/BTO_0003192|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human transitional cell carcinoma of the renal pelvis.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004991,XPMUser,2011-02-26T05:04:41Z,,,,,BrendaTissueOBO,,BTO:0004991,,,,,,,,,,,,,,,,,,,UM-UC-14 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003280,"[""sessile cell""]",,A permanently attached or established cell: not free to move about.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002322,,,,,,,,A permanently attached or established cell: not free to move about.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003280,,,,,,,BrendaTissueOBO,,BTO:0003280,,,,,,,,,,,,,,,,,,,sessile cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002637,"[""respiratory epithelium cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002637,,,,,,,BrendaTissueOBO,airway epithelium cell line,BTO:0002637,,,,,,,,,,,,,,,,,,,respiratory epithelium cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100006,"[""Tyrosine-protein kinase abl1""]",,"tyrosine-protein kinase abl1 (ABL1(Q252H)-nonphosphorylated)  with  mutation H252 in ABL1(Q252H)-nonphosphorylated in a nonphosphorylated state|tyrosine-protein kinase abl1 (ABL1(H396P)-phosphorylated)  with  mutation P396 in ABL1(H396P)-phosphorylated in a phosphorylated state|tyrosine-protein kinase abl1 (ABL1(M351T))  with  mutation T351 in ABL1(M351T) in a nonphosphorylated state|tyrosine-protein kinase abl1 (ABL1(H396P)-nonphosphorylated)  with  mutation P396 in ABL1(H396P)-nonphosphorylated in a nonphosphorylated state|tyrosine-protein kinase abl1 (ABL1(F317I)-nonphosphorylated)  with  mutation I317 in ABL1(F317I)-nonphosphorylated in a nonphosphorylated state|tyrosine-protein kinase abl1 (ABL1(Q252H)-phosphorylated)  with  mutation H252 in ABL1(Q252H)-phosphorylated in a phosphorylated state|tyrosine-protein kinase abl1 (ABL1(T315I)-nonphosphorylated)  with  mutation I315 in ABL1(T315I)-nonphosphorylated in a nonphosphorylated state|tyrosine-protein kinase abl1 (ABL1-phosphorylated)  with  no mutation  in a phosphorylated state|tyrosine-protein kinase abl1 (ABL1(T315I)-phosphorylated)  with  mutation I315 in ABL1(T315I)-phosphorylated in a phosphorylated state|tyrosine-protein kinase abl1 (ABL1(E255K))  with  mutation K255 in ABL1(E255K) in a nonphosphorylated state|A tyrosine-protein kinase ABL1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00519] |tyrosine-protein kinase abl1 (ABL1(F317I)-phosphorylated)  with  mutation I317 in ABL1(F317I)-phosphorylated in a phosphorylated state|tyrosine-protein kinase abl1 (ABL1(F317L)-nonphosphorylated)  with  mutation L317 in ABL1(F317L)-nonphosphorylated in a nonphosphorylated state|tyrosine-protein kinase abl1 (ABL1(Y253F)-phosphorylated)  with  mutation F253 in ABL1(Y253F)-phosphorylated in a phosphorylated state|tyrosine-protein kinase abl1 (ABL1(Y253F))  with  mutation F253 in ABL1(Y253F) in a nonphosphorylated state|tyrosine-protein kinase abl1 (ABL1(F317L)-phosphorylated)  with  mutation L317 in ABL1(F317L)-phosphorylated in a phosphorylated state|tyrosine-protein kinase abl1 (ABL1(E255K)-phosphorylated)  with  mutation K255 in ABL1(E255K)-phosphorylated in a phosphorylated state|tyrosine-protein kinase abl1 (ABL1(M351T)-phosphorylated)  with  mutation T351 in ABL1(M351T)-phosphorylated in a phosphorylated state|tyrosine-protein kinase abl1 (ABL1-nonphosphorylated)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300117,,,,,,,,"tyrosine-protein kinase abl1 (ABL1(Q252H)-nonphosphorylated)  with  mutation H252 in ABL1(Q252H)-nonphosphorylated in a nonphosphorylated state|tyrosine-protein kinase abl1 (ABL1(H396P)-phosphorylated)  with  mutation P396 in ABL1(H396P)-phosphorylated in a phosphorylated state|tyrosine-protein kinase abl1 (ABL1(M351T))  with  mutation T351 in ABL1(M351T) in a nonphosphorylated state|tyrosine-protein kinase abl1 (ABL1(H396P)-nonphosphorylated)  with  mutation P396 in ABL1(H396P)-nonphosphorylated in a nonphosphorylated state|tyrosine-protein kinase abl1 (ABL1(F317I)-nonphosphorylated)  with  mutation I317 in ABL1(F317I)-nonphosphorylated in a nonphosphorylated state|tyrosine-protein kinase abl1 (ABL1(Q252H)-phosphorylated)  with  mutation H252 in ABL1(Q252H)-phosphorylated in a phosphorylated state|tyrosine-protein kinase abl1 (ABL1(T315I)-nonphosphorylated)  with  mutation I315 in ABL1(T315I)-nonphosphorylated in a nonphosphorylated state|tyrosine-protein kinase abl1 (ABL1-phosphorylated)  with  no mutation  in a phosphorylated state|tyrosine-protein kinase abl1 (ABL1(T315I)-phosphorylated)  with  mutation I315 in ABL1(T315I)-phosphorylated in a phosphorylated state|tyrosine-protein kinase abl1 (ABL1(E255K))  with  mutation K255 in ABL1(E255K) in a nonphosphorylated state|A tyrosine-protein kinase ABL1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00519] |tyrosine-protein kinase abl1 (ABL1(F317I)-phosphorylated)  with  mutation I317 in ABL1(F317I)-phosphorylated in a phosphorylated state|tyrosine-protein kinase abl1 (ABL1(F317L)-nonphosphorylated)  with  mutation L317 in ABL1(F317L)-nonphosphorylated in a nonphosphorylated state|tyrosine-protein kinase abl1 (ABL1(Y253F)-phosphorylated)  with  mutation F253 in ABL1(Y253F)-phosphorylated in a phosphorylated state|tyrosine-protein kinase abl1 (ABL1(Y253F))  with  mutation F253 in ABL1(Y253F) in a nonphosphorylated state|tyrosine-protein kinase abl1 (ABL1(F317L)-phosphorylated)  with  mutation L317 in ABL1(F317L)-phosphorylated in a phosphorylated state|tyrosine-protein kinase abl1 (ABL1(E255K)-phosphorylated)  with  mutation K255 in ABL1(E255K)-phosphorylated in a phosphorylated state|tyrosine-protein kinase abl1 (ABL1(M351T)-phosphorylated)  with  mutation T351 in ABL1(M351T)-phosphorylated in a phosphorylated state|tyrosine-protein kinase abl1 (ABL1-nonphosphorylated)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100006,,,,https://pharos.nih.gov/idg/targets/P00519,,,,,,,,,,,,,ABL1,ABL|JTK7,,P00519,,,,,,,,Tyrosine-protein kinase abl1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001260,"[""smooth muscle""]",,"Muscle tissue that lacks cross striations, that is made up of elongated spindle-shaped cells having a central nucleus, and that is found in vertebrate visceral structures (as the stomach and bladder) as thin sheets performing functions not subject to conscious control by the mind and in all or most of the musculature of invertebrates other than arthropods.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0002385|http://purl.obolibrary.org/obo/BTO_0000887,,,,,,,,"Muscle tissue that lacks cross striations, that is made up of elongated spindle-shaped cells having a central nucleus, and that is found in vertebrate visceral structures (as the stomach and bladder) as thin sheets performing functions not subject to conscious control by the mind and in all or most of the musculature of invertebrates other than arthropods.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001260,,,,,,,BrendaTissueOBO,,BTO:0001260,,,,,,,,,,,,,,,,,,,smooth muscle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003632,"[""cervicovaginal fluid""]",,The fluid of the uterine cervix and the vagina.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The fluid of the uterine cervix and the vagina.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003632,,,,,,,BrendaTissueOBO,,BTO:0003632,,,,,,,,,,,,,,,,,,,cervicovaginal fluid,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_229,"[""female reproductive system disease""]",,"A reproductive system disease that impairs the ability to reproduce and is located in the uterus, vagina, cervix, ovaries or fallopian tubes.",false,,,http://purl.obolibrary.org/obo/DOID_15,,,,,,,,"A reproductive system disease that impairs the ability to reproduce and is located in the uterus, vagina, cervix, ovaries or fallopian tubes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:229,,,,ICD9CM:629.9|MESH:D005831|UMLS_CUI:C0017411|SNOMEDCT_US_2016_03_01:198486002|SNOMEDCT_US_2016_03_01:244938009|SNOMEDCT_US_2016_03_01:266680004|SNOMEDCT_US_2016_03_01:156032001|SNOMEDCT_US_2016_03_01:310789003|SNOMEDCT_US_2016_03_01:156066005|SNOMEDCT_US_2016_03_01:38233001,,,disease_ontology,,DOID:229,,,,,,,,,,,,,,,,,,,female reproductive system disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_227,"[""ankylosis""]",,"Ankylosis is a arthropathy where there is a stiffness of a joint, the result of injury or disease. The rigidity may be complete or partial and may be due to inflammation of the tendinous or muscular structures outside the joint or of the tissues of the joint itself.",false,,,http://purl.obolibrary.org/obo/DOID_381,,,,,,,,"Ankylosis is a arthropathy where there is a stiffness of a joint, the result of injury or disease. The rigidity may be complete or partial and may be due to inflammation of the tendinous or muscular structures outside the joint or of the tissues of the joint itself.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:227,,,,MESH:D000844|ICD9CM:718.50|ICD10CM:M24.6|SNOMEDCT_US_2016_03_01:202323002|SNOMEDCT_US_2016_03_01:36504009|ICD9CM:718.5|SNOMEDCT_US_2016_03_01:111227009|UMLS_CUI:C0003090|SNOMEDCT_US_2016_03_01:156559001|SNOMEDCT_US_2016_03_01:156569007|SNOMEDCT_US_2016_03_01:202297005,,,disease_ontology,,DOID:227,,,,,,,,,,,,,,,,,,,ankylosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_224,"[""transient cerebral ischemia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2316,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:224,,,DOID:2315,SNOMEDCT_US_2016_03_01:155404005|ICD9CM:435.8|MESH:D002546|SNOMEDCT_US_2016_03_01:195207009|NCI:C50781|UMLS_CUI:C0155728|UMLS_CUI:C0007787|SNOMEDCT_US_2016_03_01:38609002|ICD10CM:G45.9|SNOMEDCT_US_2016_03_01:266314007|SNOMEDCT_US_2016_03_01:266257000|SNOMEDCT_US_2016_03_01:313242003|SNOMEDCT_US_2016_03_01:195196001,TRANSIENT ISCHEMIC ATTACK|Transient cerebral ischaemia NOS|Transient ischemic attacks (disorder)|transient ischemic attack|Transient cerebral ischaemia|TIA|TIA - Transient ischaemic attack|Transient cerebral ischemia (disorder) [Ambiguous],,disease_ontology,,DOID:224,,,,,,,,,,,,,,,,,,,transient cerebral ischemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_225,"[""syndrome""]",,A disease comprised of a group of signs and symptoms that occur together and characterize a particular abnormality.,false,,,http://purl.obolibrary.org/obo/DOID_4,,,,,,,,A disease comprised of a group of signs and symptoms that occur together and characterize a particular abnormality.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:225,,,,MESH:D013577|SNOMEDCT_US_2016_03_01:64572001|NCI:C28193|UMLS_CUI:C0039082,,,disease_ontology,,DOID:225,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12987,"[""agranulocytosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_615,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12987,,,,SNOMEDCT_US_2016_03_01:310589001|NCI:C2863|SNOMEDCT_US_2016_03_01:191336001|SNOMEDCT_US_2016_03_01:72885007|UMLS_CUI:C0001824|SNOMEDCT_US_2016_03_01:191350006|ICD10CM:D70|SNOMEDCT_US_2016_03_01:165508008|SNOMEDCT_US_2016_03_01:142919000|SNOMEDCT_US_2016_03_01:417672002|SNOMEDCT_US_2016_03_01:17182001|MESH:D000380|SNOMEDCT_US_2016_03_01:154830007,Granulocytopenic disorder|Granulopenia|granulocytopenia,,disease_ontology,,DOID:12987,,,,,,,,,,,,,,,,,,,agranulocytosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000467,"[""flight muscle""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0002385|http://purl.obolibrary.org/obo/BTO_0000887,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000467,,,,,,,BrendaTissueOBO,,BTO:0000467,,,,,,,,,,,,,,,,,,,flight muscle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004242,"[""vitellarium""]",,"The female system is unusual in that it is separated into two structures: the ovaries and the vitellaria, often known as the vitelline glands or yolk glands. The cells of the vitellaria form yolk and eggshell components.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The female system is unusual in that it is separated into two structures: the ovaries and the vitellaria, often known as the vitelline glands or yolk glands. The cells of the vitellaria form yolk and eggshell components.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004242,,,,,,,BrendaTissueOBO,vitelline gland|yolk gland,BTO:0004242,,,,,,,,,,,,,,,,,,,vitellarium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001333,"[""sympathetic ganglion""]",,"Any of the aggregations of cell bodies of primarily adrenergic neurons of the sympathetic nervous system, including the ganglia of the sympathetic trunks, the intermediate ganglia, the prevertebral ganglia, and some ganglionic cells in the autonomic plexuses.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000497,,,,,,,,"Any of the aggregations of cell bodies of primarily adrenergic neurons of the sympathetic nervous system, including the ganglia of the sympathetic trunks, the intermediate ganglia, the prevertebral ganglia, and some ganglionic cells in the autonomic plexuses.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001333,,,,,,,BrendaTissueOBO,ganglion sympathicum|ganglion sympatheticum,BTO:0001333,,,,,,,,,,,,,,,,,,,sympathetic ganglion,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003726,"[""SHP-77 cell""]",,Small cell lung cancer cell line; established in 1977; derived from a non-encapsulated primary lung tumor from the apical portion of the upper lobe of the left lung. This cell line is an unusual undifferentiated large cell variant of small cell lung carcinoma.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002206,,,,,,,,Small cell lung cancer cell line; established in 1977; derived from a non-encapsulated primary lung tumor from the apical portion of the upper lobe of the left lung. This cell line is an unusual undifferentiated large cell variant of small cell lung carcinoma.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003726,,,,,,,BrendaTissueOBO,,BTO:0003726,,,,,,,,,,,,,,,,,,,SHP-77 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_47,"[""prostate disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_48,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:47,,,,ICD9CM:602.9|SNOMEDCT_US_2016_03_01:30281009|UMLS_CUI:C0033575|MESH:D011469|NCI:C26865|SNOMEDCT_US_2016_03_01:197979000|ICD10CM:N42.9,,,disease_ontology,,DOID:47,,,,,,,,,,,,,,,,,,,prostate disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_471,"[""skin hemangioma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_255|http://purl.obolibrary.org/obo/DOID_3165,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:471,,,,SNOMEDCT_US_2016_03_01:254773009|SNOMEDCT_US_2016_03_01:189195009|UMLS_CUI:C0687140|NCI:C4905|SNOMEDCT_US_2016_03_01:93471006,Angioma of the skin|Angiomatous naevus of skin|hemangioma of skin (disorder),,disease_ontology,,DOID:471,,,,,,,,,,,,,,,,,,,skin hemangioma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001616,"[""colorectal cancer cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0001614|http://purl.obolibrary.org/obo/BTO_0000797|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001532,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001616,,,,,,,BrendaTissueOBO,CRC cell line,BTO:0001616,,,,,,,,,,,,,,,,,,,colorectal cancer cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100032,"[""Beta-adrenergic receptor kinase 2""]",,"A beta-adrenergic receptor kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35626] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300250,,,,,,,,"A beta-adrenergic receptor kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35626] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100032,,,,https://pharos.nih.gov/idg/targets/P35626,,,,,,,,,,,,,ADRBK2,BARK2|GRK3,,P35626,,,,,,,,Beta-adrenergic receptor kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000311,"[""THR227 in WNK3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000311,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR227 in WNK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000764,"[""lung fibroblast""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000452,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000764,,,,,,,BrendaTissueOBO,,BTO:0000764,,,,,,,,,,,,,,,,,,,lung fibroblast,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200446,"[""OR5AC2 gene""]",,"An olfactory receptor 5AC2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZP5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5AC2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZP5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200446,,,,,,,,,,,,,,,,81050,OR5AC2,,,,,,,,,,,OR5AC2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200799,"[""TAS2R9 gene""]",,"A taste receptor type 2 member 9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400014,,,,,,,,"A taste receptor type 2 member 9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYW1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200799,,,,,,,,,,,,,,,,50835,TAS2R9,,,,,,,,,,,TAS2R9 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200176,"[""HUNK gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491034,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200176,,,,,,,,,,,,,,,,30811,HUNK,MAKV,,,,,,,,,,HUNK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200114,"[""GABBR2 gene""]",,"A gamma-aminobutyric acid type B receptor subunit 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75899] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400045,,,,,,,,"A gamma-aminobutyric acid type B receptor subunit 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75899] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200114,,,,,,,,,,,,,,,,9568,GABBR2,GPR51|GPRC3B,,,,,,,,,,GABBR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000280,"[""PHE79 in MAK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000280,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE79 in MAK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2154,"[""nephroblastoma""]",,A kidney cancer that affects the kidneys and typically located_in children.,false,,,http://purl.obolibrary.org/obo/DOID_263,,,,,,,,A kidney cancer that affects the kidneys and typically located_in children.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2154,,,DOID:5177|DOID:5180,SNOMEDCT_US_2016_03_01:302849000|UMLS_CUI:C1333015|NCI:C3267|OMIM:194070|NCI:C27730|SNOMEDCT_US_2016_03_01:25081006|UMLS_CUI:C0027708|MESH:D009396|UMLS_CUI:C1332219|NCI:C6180|NCI:C40407|SNOMEDCT_US_2016_03_01:31470003,adult renal Wilms' tumor|adult nephroblastoma|renal Wilms tumor|childhood renal Wilms' cancer,,disease_ontology,Wilms' tumor|childhood renal Wilms tumor,DOID:2154,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,nephroblastoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4960,"[""bone marrow cancer""]",,A hematopoietic cancer that derives_from the blood-forming stem cells of the bone marrow.,false,,,http://purl.obolibrary.org/obo/DOID_4961|http://purl.obolibrary.org/obo/DOID_2531,,,,,,,,A hematopoietic cancer that derives_from the blood-forming stem cells of the bone marrow.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4960,,,DOID:2356|DOID:2761,MESH:D009196|SNOMEDCT_US_2016_03_01:414794006|SNOMEDCT_US_2016_03_01:20921005|EFO:0004251|SNOMEDCT_US_2016_03_01:425333006|UMLS_CUI:C0027022|ICD10CM:D47.1|SNOMEDCT_US_2016_03_01:128925001|SNOMEDCT_US_2016_03_01:188772004,bone marrow neoplasm|bone Marrow tumor|malignant neoplasm of bone marrow|malignant bone Marrow tumor,,disease_ontology,,DOID:4960,,,,,,,,,,,,,,,,,,,bone marrow cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001138,"[""somatic embryo""]",,"An organized embryonic structure morphologically similar to a zygotic embryo but initiated from somatic non-zygotic cells. Under in vitro conditions, somatic embryos go through developmental processes similar to embryos of zygotic origin.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000379,,,,,,,,"An organized embryonic structure morphologically similar to a zygotic embryo but initiated from somatic non-zygotic cells. Under in vitro conditions, somatic embryos go through developmental processes similar to embryos of zygotic origin.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001138,,,,,,,BrendaTissueOBO,somatic embryoid,BTO:0001138,,,,,,,,,,,,,,,,,,,somatic embryo,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100154,"[""Receptor-type tyrosine-protein kinase flt3""]",,"receptor-type tyrosine-protein kinase flt3 (FLT3(ITD))  with  mutation ITD in FLT3(ITD) in a nonphosphorylated state|A receptor-type tyrosine-protein kinase FLT3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P36888] |receptor-type tyrosine-protein kinase flt3 (FLT3(K663Q))  with  mutation Q663 in FLT3(K663Q) in a nonphosphorylated state|receptor-type tyrosine-protein kinase flt3 (FLT3(D835H))  with  mutation H835 in FLT3(D835H) in a nonphosphorylated state|receptor-type tyrosine-protein kinase flt3 (FLT3(R834Q))  with  mutation Q834 in FLT3(R834Q) in a nonphosphorylated state|receptor-type tyrosine-protein kinase flt3 (FLT3)  with  no mutation  in a nonphosphorylated state|receptor-type tyrosine-protein kinase flt3 (FLT3(N841I))  with  mutation I841 in FLT3(N841I) in a nonphosphorylated state|receptor-type tyrosine-protein kinase flt3 (FLT3-autoinhibited)  with  no mutation  in a nonphosphorylated state|receptor-type tyrosine-protein kinase flt3 (FLT3(D835Y))  with  mutation Y835 in FLT3(D835Y) in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300141,,,,,,,,"receptor-type tyrosine-protein kinase flt3 (FLT3(ITD))  with  mutation ITD in FLT3(ITD) in a nonphosphorylated state|A receptor-type tyrosine-protein kinase FLT3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P36888] |receptor-type tyrosine-protein kinase flt3 (FLT3(K663Q))  with  mutation Q663 in FLT3(K663Q) in a nonphosphorylated state|receptor-type tyrosine-protein kinase flt3 (FLT3(D835H))  with  mutation H835 in FLT3(D835H) in a nonphosphorylated state|receptor-type tyrosine-protein kinase flt3 (FLT3(R834Q))  with  mutation Q834 in FLT3(R834Q) in a nonphosphorylated state|receptor-type tyrosine-protein kinase flt3 (FLT3)  with  no mutation  in a nonphosphorylated state|receptor-type tyrosine-protein kinase flt3 (FLT3(N841I))  with  mutation I841 in FLT3(N841I) in a nonphosphorylated state|receptor-type tyrosine-protein kinase flt3 (FLT3-autoinhibited)  with  no mutation  in a nonphosphorylated state|receptor-type tyrosine-protein kinase flt3 (FLT3(D835Y))  with  mutation Y835 in FLT3(D835Y) in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100154,,,,https://pharos.nih.gov/idg/targets/P36888,,,,,,,,,,,,,FLT3,CD135|FLK2|STK1,,P36888,,,,,,,,Receptor-type tyrosine-protein kinase flt3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000343,"[""PIK3CA(E542K) kinase domain""]",,"Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000343,,,,,,,,,,,,,,,,,,,200325,,,,,,,,,PIK3CA(E542K) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100445,"[""Olfactory receptor 5ac1""]",,"An olfactory receptor 5AC1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C628] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5AC1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C628] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100445,,,,https://pharos.nih.gov/idg/targets/P0C628,,,,,,,,,,,,,OR5AC1,OR5AC1P,,P0C628,,,,,,,,Olfactory receptor 5ac1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200256,"[""MCHR2 gene""]",,"A melanin-concentrating hormone receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q969V1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400052,,,,,,,,"A melanin-concentrating hormone receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q969V1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200256,,,,,,,,,,,,,,,,84539,MCHR2,GPR145|SLT,,,,,,,,,,MCHR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100573,"[""Ethanolamine kinase 1""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100573,,,,,,,,,,,,,,,,,ETNK1,,,Q9HBU6,,,,,,,,Ethanolamine kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001329,"[""gastrinoma cell""]",,"A tumor cell that secretes gastrin; most are islet cell tumors of non-beta cells in the pancreas, but some are found at sites such as the antrum of the stomach, the hilus of the spleen, or regional lymph nodes. This is the usual cause of Zollinger-Ellison syndrome.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000566,,,,,,,,"A tumor cell that secretes gastrin; most are islet cell tumors of non-beta cells in the pancreas, but some are found at sites such as the antrum of the stomach, the hilus of the spleen, or regional lymph nodes. This is the usual cause of Zollinger-Ellison syndrome.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001329,,,,,,,BrendaTissueOBO,,BTO:0001329,,,,,,,,,,,,,,,,,,,gastrinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100068,"[""Cyclin-dependent kinase 2""]",,A cyclin-dependent kinase 2 that is encoded in the genome of human. |cyclin-dependent kinase 2 (CDK2)  with  no mutation  in a nonphosphorylated state,false,,,http://www.drugtargetontology.org/dto/DTO_03300258,,,,,,,,A cyclin-dependent kinase 2 that is encoded in the genome of human. |cyclin-dependent kinase 2 (CDK2)  with  no mutation  in a nonphosphorylated state,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100068,,,,https://pharos.nih.gov/idg/targets/P24941,,,,,,,,,,,,,CDK2,CDKN2,,P24941,,,,,,,,Cyclin-dependent kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004799,"[""AILNCaP cell""]",,"A prostate cancer cell line, that proliferates under androgen-depleted conditions after emerging from long-term, androgen- depleted culture of the androgen-sensitive prostate cancer cell line LNCaP.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A prostate cancer cell line, that proliferates under androgen-depleted conditions after emerging from long-term, androgen- depleted culture of the androgen-sensitive prostate cancer cell line LNCaP.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004799,mgr,2010-10-05T09:39:11Z,,,,,BrendaTissueOBO,,BTO:0004799,,,,,,,,,,,,,,,,,,,AILNCaP cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100202,"[""G-protein coupled receptor 56""]",,"A G-protein coupled receptor 56 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y653] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,"A G-protein coupled receptor 56 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y653] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100202,,,,https://pharos.nih.gov/idg/targets/Q9Y653,,,,,,,,,,,,,GPR56,ADGRG1|TM7LN4|TM7XN1,,Q9Y653,,,,,,,,G-protein coupled receptor 56,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300370,"[""Sodium channel auxiliary subunit 1-4 (sca-) family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300370,,,,,,,,,,,,,,,,,,,,,,,,,,,,Sodium channel auxiliary subunit 1-4 (sca-) family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200233,"[""CAMKK2 gene""]",,"The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400275,,,,,,,,"The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200233,,,,,,,,,,,,,,,,10645,CAMKK2,CAMKKB|KIAA0787,,,,,,,,,,CAMKK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400264,"[""CHK1 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400116,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400264,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHK1 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200544,"[""TSSK6 gene""]",,"This intronless gene encodes a member of the CAMK (calcium/calmodulin-dependent) serine/threonine protein kinase family. The encoded kinase has a broad expression pattern but is described as testis-specific due to effects on fertility. Male mice which lack the gene encoding a highly similar protein are sterile and have morphologically abnormal sperm. [provided by RefSeq, Jan 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400238,,,,,,,,"This intronless gene encodes a member of the CAMK (calcium/calmodulin-dependent) serine/threonine protein kinase family. The encoded kinase has a broad expression pattern but is described as testis-specific due to effects on fertility. Male mice which lack the gene encoding a highly similar protein are sterile and have morphologically abnormal sperm. [provided by RefSeq, Jan 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200544,,,,,,,,,,,,,,,,83983,TSSK6,SSTK,,,,,,,,,,TSSK6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000225,"[""MET93 in AMPK-alpha2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000225,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET93 in AMPK-alpha2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100438,"[""Olfactory receptor 56a1""]",,"An olfactory receptor 56A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 56A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGH5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100438,,,,https://pharos.nih.gov/idg/targets/Q8NGH5,,,,,,,,,,,,,OR56A1,,,Q8NGH5,,,,,,,,Olfactory receptor 56a1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9589,"[""urethral calculus""]",,,false,,,http://purl.obolibrary.org/obo/DOID_9590,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9589,,,,ICD10CM:N21.1|UMLS_CUI:C0162301|NCI:C26995|SNOMEDCT_US_2016_03_01:20342001|ICD9CM:594.2|SNOMEDCT_US_2016_03_01:155880008,urethral Stone,,disease_ontology,,DOID:9589,,,,,,,,,,,,,,,,,,,urethral calculus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_15741,"[""Succinic acid""]","Dihydrofumaric acid|butanedioic acid|Wormwood acid|acide succinique|Butandisaeure|Succinate|asuccin|acidum succinicum|
InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)
|1,4-Butanedioate|KDYFGRWQOYBRFD-UHFFFAOYSA-N|Ethylenesuccinic acid|1,4-Butanedioic acid|HOOC-CH2-CH2-COOH|Katasuccin|Butanedionic acid|OC(=O)CCC(O)=O|amber acid|acide butanedioique|1,2-ethanedicarboxylic acid|E363|C4H6O4|spirit of amber|Bernsteinsaeure|Dihydrofumarate|1,2-Ethanedicarboxylate","
An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.
",false,,,http://purl.obolibrary.org/obo/CHEBI_33575,,,,,,,CiteXplore:8412012|KEGG COMPOUND:110-15-6|MetaCyc:SUC|CiteXplore:12097436|CiteXplore:19212411|CiteXplore:6882030|CiteXplore:11803021|CiteXplore:22932811|CiteXplore:18953024|Reaxys:1754069|HMDB:HMDB00254|CiteXplore:17439666|CiteXplore:1126459|ChemIDplus:110-15-6|CiteXplore:15059451|CiteXplore:7729054|NIST Chemistry WebBook:110-15-6|CiteXplore:11067816|Wikipedia:Succinic_acid|CiteXplore:24027187|CiteXplore:14687733|ECMDB:ECMDB00254|LIPID MAPS:LMFA01170043|DrugBank:DB00139|PDBeChem:SIN|CiteXplore:7582870|Beilstein:1754069|CiteXplore:9693263|CiteXplore:8013094|CiteXplore:3659829|Wikipedia:Succinic acid|Gmelin:2785|YMDB:YMDB00338|CiteXplore:16143825|CiteXplore:8087979|CiteXplore:21848266|KNApSAcK:C00001205|KEGG COMPOUND:C00042|CiteXplore:20669995,"
An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:9304|CHEBI:22943|CHEBI:45639|CHEBI:26807,,butanedioic acid|SUCCINIC ACID|succinic acid|Succinic acid,,chebi_ontology,"Dihydrofumaric acid|butanedioic acid|Wormwood acid|acide succinique|Butandisaeure|Succinate|asuccin|acidum succinicum|
InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)
|1,4-Butanedioate|KDYFGRWQOYBRFD-UHFFFAOYSA-N|Ethylenesuccinic acid|1,4-Butanedioic acid|HOOC-CH2-CH2-COOH|Katasuccin|Butanedionic acid|OC(=O)CCC(O)=O|amber acid|acide butanedioique|1,2-ethanedicarboxylic acid|E363|C4H6O4|spirit of amber|Bernsteinsaeure|Dihydrofumarate|1,2-Ethanedicarboxylate",,,CHEBI:15741,,,,,,,,,,,,,,,,,,,,,,,CHEBI:15741,,,,,succinic acid|Succinic acid,,CHEBI:15741,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200089,"[""CNGB1 gene""]",,"In humans, the rod photoreceptor cGMP-gated cation channel helps regulate ion flow into the rod photoreceptor outer segment in response to light-induced alteration of the levels of intracellular cGMP. This channel consists of two subunits, alpha and beta, with the protein encoded by this gene representing the beta subunit. Defects in this gene are a cause of cause of retinitis pigmentosa type 45. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_01400406,,,,,,,,"In humans, the rod photoreceptor cGMP-gated cation channel helps regulate ion flow into the rod photoreceptor outer segment in response to light-induced alteration of the levels of intracellular cGMP. This channel consists of two subunits, alpha and beta, with the protein encoded by this gene representing the beta subunit. Defects in this gene are a cause of cause of retinitis pigmentosa type 45. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200089,,,,,,,,,,,,,,,,1258,CNGB1,CNCG2|CNCG3L|CNCG4|RCNC2,,,,,,,,,,CNGB1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400420,"[""GRIK5 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400420,,,,,,,,,,,,,,,,,,,,,,,,,,,,GRIK5 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003877,"[""G-292 cell""]",,Human osteosarcoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000407,,,,,,,,Human osteosarcoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003877,,,,,,,BrendaTissueOBO,G292 cell,BTO:0003877,,,,,,,,,,,,,,,,,,,G-292 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80331,"[""Vasoactive intestinal peptide""]",VIP,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,CAS:37221-79-7|KEGG:C16119,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,VIP,,,CHEBI:80331,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80331,,,,,Vasoactive intestinal peptide,,CHEBI:80331,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004979,"[""glossopharyngeal nerve""]",,"The glossopharyngeal nerve is the ninth (IX) of twelve pairs of cranial nerves. It exits the brainstem out from the sides of the upper medulla, just rostral (closer to the nose) to the vagus nerve.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001104,,,,,,,,"The glossopharyngeal nerve is the ninth (IX) of twelve pairs of cranial nerves. It exits the brainstem out from the sides of the upper medulla, just rostral (closer to the nose) to the vagus nerve.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004979,XPMUser,2011-02-26T10:43:43Z,,,,,BrendaTissueOBO,cranial nerve IX,BTO:0004979,,,,,,,,,,,,,,,,,,,glossopharyngeal nerve,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5557,"[""testicular germ cell cancer""]",,A testicular cancer that has_material_basis_in germ cells.,false,,,http://purl.obolibrary.org/obo/DOID_2998,,,,,,,,A testicular cancer that has_material_basis_in germ cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5557,,,,SNOMEDCT_US_2016_03_01:713577007|OMIM:300228|ORDO:3636504|NCI:C8591|OMIM:273300|MESH:C563236|UMLS_CUI:C1336708,germ cell tumor of testis,,disease_ontology,testicular germ cell neoplasm,DOID:5557,http://purl.obolibrary.org/obo/doid#DO_cancer_slim|http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [LS].",,testicular germ cell cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000187,"[""MET589 in MLCK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000187,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET589 in MLCK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4556,"[""lung large cell carcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4552|http://purl.obolibrary.org/obo/DOID_3908,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4556,,,,NCI:C4450|UMLS_CUI:C0345958|SNOMEDCT_US_2016_03_01:254629004,large cell carcinoma of lung (disorder)|large cell lung carcinoma,,disease_ontology,,DOID:4556,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,lung large cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000855,"[""lymph""]",,"A clear, watery, sometimes faintly yellowish fluid derived from body tissues that contains white blood cells and circulates throughout the lymphatic system, returning to the venous bloodstream through the thoracic duct. Lymph acts to remove bacteria and certain proteins from the tissues, transport fat from the small intestine, and supply mature lymphocytes to the blood.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A clear, watery, sometimes faintly yellowish fluid derived from body tissues that contains white blood cells and circulates throughout the lymphatic system, returning to the venous bloodstream through the thoracic duct. Lymph acts to remove bacteria and certain proteins from the tissues, transport fat from the small intestine, and supply mature lymphocytes to the blood.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000855,,,,,,,BrendaTissueOBO,,BTO:0000855,,,,,,,,,,,,,,,,,,,lymph,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100121,"[""Eukaryotic translation initiation factor 2-alpha kinase 4""]",,"A eukaryotic translation initiation factor 2-alpha kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P2K8] |eukaryotic translation initiation factor 2-alpha kinase 4 (GCN2(Kin.Dom.2,S808G))  with  mutation G808 in GCN2(Kin.Dom.2,S808G) in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300269,,,,,,,,"A eukaryotic translation initiation factor 2-alpha kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P2K8] |eukaryotic translation initiation factor 2-alpha kinase 4 (GCN2(Kin.Dom.2,S808G))  with  mutation G808 in GCN2(Kin.Dom.2,S808G) in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100121,,,,https://pharos.nih.gov/idg/targets/Q9P2K8,,,,,,,,,,,,,EIF2AK4,GCN2|KIAA1338,,Q9P2K8,,,,,,,,Eukaryotic translation initiation factor 2-alpha kinase 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000519,"[""gingiva""]",,The tissue that surrounds the necks of teeth and covers the alveolar parts of the jaws; broadly: the alveolar portion of a jaw with its enveloping soft tissues.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The tissue that surrounds the necks of teeth and covers the alveolar parts of the jaws; broadly: the alveolar portion of a jaw with its enveloping soft tissues.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000519,,,,,,,BrendaTissueOBO,gum,BTO:0000519,,,,,,,,,,,,,,,,,,,gingiva,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000400,"[""sarcoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000400,,,,,,,BrendaTissueOBO,,BTO:0000400,,,,,,,,,,,,,,,,,,,sarcoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000268,"[""PHE655 in MUSK""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000268,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE655 in MUSK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300500,"[""Beta-3/CHRNB3 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300500,,,,,,,,,,,,,,,,,,,,,,,,,,,,Beta-3/CHRNB3 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300381,"[""CACNA1A subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300333,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300381,,,,,,,,,,,,,,,,,,,,,,,,,,,,CACNA1A subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300522,"[""GABRR2 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300522,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRR2 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200160,"[""GRK4 gene""]",,"This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400271,,,,,,,,"This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200160,,,,,,,,,,,,,,,,2868,GRK4,GPRK2L|GPRK4,,,,,,,,,,GRK4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200125,"[""GNRHR gene""]",,"A gonadotropin-releasing hormone I receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30968] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400050,,,,,,,,"A gonadotropin-releasing hormone I receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30968] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200125,,,,,,,,,,,,,,,,2798,GNRHR,GRHR,,,,,,,,,,GNRHR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1754,"[""mitral valve stenosis""]",,A mitral valve disease that is characterized by the narrowing of the orifice of the mitral valve of the heart.,false,,,http://purl.obolibrary.org/obo/DOID_61,,,,,,,,A mitral valve disease that is characterized by the narrowing of the orifice of the mitral valve of the heart.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1754,,,,NCI:C50654|MESH:D008946|SNOMEDCT_US_2016_03_01:194725005|SNOMEDCT_US_2016_03_01:155277002|SNOMEDCT_US_2016_03_01:79619009|UMLS_CUI:C0026269,Mitral stenosis,,disease_ontology,,DOID:1754,,,,,,,,,,,,,,,,,,,mitral valve stenosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100187,"[""Inositol-trisphosphate 3-kinase a""]",,"An inositol-trisphosphate 3-kinase A that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23677] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391019,,,,,,,,"An inositol-trisphosphate 3-kinase A that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23677] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100187,,,,https://pharos.nih.gov/idg/targets/P23677,,,,,,,,,,,,,ITPKA,,,P23677,,,,,,,,Inositol-trisphosphate 3-kinase a,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400448,"[""H (Eag) subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400448,,,,,,,,,,,,,,,,,,,,,,,,,,,,H (Eag) subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100407,"[""Phosphorylase b kinase gamma catalytic chain, liver/testis isoform""]",,"A phosphorylase b kinase gamma catalytic chain, testis/liver isoform that is encoded in the genome of human. |phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHKG2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300205,,,,,,,,"A phosphorylase b kinase gamma catalytic chain, testis/liver isoform that is encoded in the genome of human. |phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHKG2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100407,,,,https://pharos.nih.gov/idg/targets/P15735,,,,,,,,,,,,,PHKG2,,,P15735,,,,,,,,"Phosphorylase b kinase gamma catalytic chain, liver/testis isoform",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005097,"[""skin stem cell""]",,Skin stem cells occur in the basal layer of the epidermis and at the base of hair follicles.,false,,,http://purl.obolibrary.org/obo/BTO_0002666|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Skin stem cells occur in the basal layer of the epidermis and at the base of hair follicles.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005097,XPMUser,2011-03-21T08:25:47Z,,,,,BrendaTissueOBO,,BTO:0005097,,,,,,,,,,,,,,,,,,,skin stem cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000305,"[""THR108 in NEK11""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000305,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR108 in NEK11,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100604,"[""Olfactory receptor 4P4""]",,"An olfactory receptor 4P4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4P4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100604,,,,https://pharos.nih.gov/idg/targets/Q8NGL7,,,,,,,,,,,,,OR4P4,OR4P3P,,Q8NGL7,,,,,,,,Olfactory receptor 4P4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100321,"[""Olfactory receptor 10r2""]",,"An olfactory receptor 10R2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10R2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100321,,,,https://pharos.nih.gov/idg/targets/Q8NGX6,,,,,,,,,,,,,OR10R2,,,Q8NGX6,,,,,,,,Olfactory receptor 10r2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000356,"[""PIM2 kinase domain""]",,Pim-2 oncogene; PIM2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Pim-2 oncogene; PIM2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000356,,,,,,,,,,,,,,,,,,,200338,,,,,,,,,PIM2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100317,"[""Two pore calcium channel protein 1""]",,"A two pore calcium channel protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9ULQ1] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300481,,,,,,,,"A two pore calcium channel protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9ULQ1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100317,,,,https://pharos.nih.gov/idg/targets/Q9ULQ1,,,,,,,,,,,,,TPCN1,KIAA1169|TPC1,,Q9ULQ1,,,,,,,,Two pore calcium channel protein 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001025,"[""peripheral blood mononuclear cell""]",,A mixture of monocytes and lymphocytes; blood leucocytes from which granulocytes have been separated and removed.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000878,,,,,,,,A mixture of monocytes and lymphocytes; blood leucocytes from which granulocytes have been separated and removed.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001025,,,,,,,BrendaTissueOBO,PBM cell|PBMC cell|PBMC,BTO:0001025,,,,,,,,,,,,,,,,,,,peripheral blood mononuclear cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200810,"[""TAS1R1 gene""]",,"A taste receptor type 1 member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7RTX1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400015,,,,,,,,"A taste receptor type 1 member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7RTX1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200810,,,,,,,,,,,,,,,,80835,TAS1R1,GPR70|T1R1|TR1,,,,,,,,,,TAS1R1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_7725,"[""epilepsy with generalized tonic-clonic seizures""]",,An adolescence-adult electroclinical syndrome starting in adolescence exhibiting generalized tonic-clonic seizures as the only seizure type.,false,,,http://purl.obolibrary.org/obo/DOID_0050705,,,,,,,,An adolescence-adult electroclinical syndrome starting in adolescence exhibiting generalized tonic-clonic seizures as the only seizure type.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:7725,,,,SNOMEDCT_US_2016_03_01:352818000|MESH:D004830|UMLS_CUI:C0014549|NCI:C3022,"tonic-clonic epilepsy|Grand Mal epilepsy|Epileptic seizures, tonic-clonic",,disease_ontology,,DOID:7725,,,,,,,,,,,,,,,,,,,epilepsy with generalized tonic-clonic seizures,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100129,"[""Glycine receptor subunit alpha-4""]",,"A glycine receptor subunit alpha-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5JXX5] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300528,,,,,,,,"A glycine receptor subunit alpha-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5JXX5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100129,,,,https://pharos.nih.gov/idg/targets/Q5JXX5,,,,,,,,,,,,,GLRA4,,,Q5JXX5,,,,,,,,Glycine receptor subunit alpha-4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003674,"[""temporomandibular joint""]",,The joint that connects the lower jaw to the skull.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001686,,,,,,,,The joint that connects the lower jaw to the skull.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003674,,,,,,,BrendaTissueOBO,TMJ,BTO:0003674,,,,,,,,,,,,,,,,,,,temporomandibular joint,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80262,"[""beta-Neoendorphin""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16040,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80262,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80262,,,,,beta-Neoendorphin,,CHEBI:80262,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200237,"[""KCNS1 gene""]",,"Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400566,,,,,,,,"Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200237,,,,,,,,,,,,,,,,3787,KCNS1,,,,,,,,,,,KCNS1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9207,"[""periodic limb movement disorder""]",,A sleep disorder that involves involuntary limb movement during sleep.,false,,,http://purl.obolibrary.org/obo/DOID_535,,,,,,,,A sleep disorder that involves involuntary limb movement during sleep.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9207,,,,UMLS_CUI:C0751774|ICD10CM:G47.61|MESH:D020189|SNOMEDCT_US_2016_03_01:418763003|ICD9CM:327.51,nocturnal myoclonus,,disease_ontology,,DOID:9207,,,,,,,,,,,,,,,,,,,periodic limb movement disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100654,"[""Olfactory receptor 6c1""]",,"An olfactory receptor 6C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 6C1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100654,,,,https://pharos.nih.gov/idg/targets/Q96RD1,,,,,,,,,,,,,OR6C1,,,Q96RD1,,,,,,,,Olfactory receptor 6c1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000651,"[""small intestine""]",,"The part of the intestine that lies between the stomach and colon, consists of duodenum, jejunum, and ileum, secretes digestive enzymes, and is the chief site of the absorption of digested nutrients. The proximal portion of the intestine.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The part of the intestine that lies between the stomach and colon, consists of duodenum, jejunum, and ileum, secretes digestive enzymes, and is the chief site of the absorption of digested nutrients. The proximal portion of the intestine.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000651,,,,,,,BrendaTissueOBO,intestinum tenue,BTO:0000651,,,,,,,,,,,,,,,,,,,small intestine,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_15552,"[""prostaglandin I2""]","352.225|InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1|KAQKFAOMNZTLHT-OZUDYXHBSA-N|prostaglandin X|Epoprostenol|Vasocyclin|PGI2|Prostacyclin|[H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)CCCCC)[C@@]1([H])C\C(O2)=C\CCCC(O)=O|352.46508|Flolan|C20H32O5|PGX|(5Z,13E)-(15S)-6,9alpha-Epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate|0|(5Z,9alpha,11alpha,13E,15S)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid",,false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,DrugBank:DB01240|KEGG:D00106|CAS:35121-78-9|KEGG:C01312|Beilstein:1690090|Drug_Central:1034|LIPID_MAPS_instance:LMFA03010087,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:245|CHEBI:10912|CHEBI:26331,,"Prostaglandin I2|(5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoic acid",,chebi_ontology,"352.225|InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1|KAQKFAOMNZTLHT-OZUDYXHBSA-N|prostaglandin X|Epoprostenol|Vasocyclin|PGI2|Prostacyclin|[H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)CCCCC)[C@@]1([H])C\C(O2)=C\CCCC(O)=O|352.46508|Flolan|C20H32O5|PGX|(5Z,13E)-(15S)-6,9alpha-Epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate|0|(5Z,9alpha,11alpha,13E,15S)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid",,,CHEBI:15552,,,,,,,,,,,,,,,,,,,,,,,CHEBI:15552,,,,,prostaglandin I2,,CHEBI:15552,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004203,"[""RIE-1 cell""]",,Rat intestinal epithelial cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000003,,,,,,,,Rat intestinal epithelial cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004203,,,,,,,BrendaTissueOBO,,BTO:0004203,,,,,,,,,,,,,,,,,,,RIE-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100064,"[""Cadherin egf lag seven-pass g-type receptor 1""]",,"A cadherin EGF LAG seven-pass G-type receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYQ6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300032,,,,,,,,"A cadherin EGF LAG seven-pass G-type receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYQ6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100064,,,,https://pharos.nih.gov/idg/targets/Q9NYQ6,,,,,,,,,,,,,CELSR1,CDHF9|FMI2,,Q9NYQ6,,,,,,,,Cadherin egf lag seven-pass g-type receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000395,"[""THR790 in EGFR(E746-A750del)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000395,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR790 in EGFR(E746-A750del),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4043,"[""skeletal muscle cancer""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4045,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4043,,,,NCI:C6516|UMLS_CUI:C1334619,malignant tumor of Skeletal Muscle,,disease_ontology,,DOID:4043,,,,,,,,,,,,,,,,,,,skeletal muscle cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400388,"[""CACNA1H subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400333,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400388,,,,,,,,,,,,,,,,,,,,,,,,,,,,CACNA1H subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300322,"[""Nucleoside kinase""]",,A Nucleoside kinase is a kinase enzyme that catalyzes the phosphorylation of a nucleoside substrate.,false,,,http://www.drugtargetontology.org/dto/DTO_03300103,,,,,,,,A Nucleoside kinase is a kinase enzyme that catalyzes the phosphorylation of a nucleoside substrate.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300322,,,,,,,,,,,,,,,,,,,,,,,,,,,,Nucleoside kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400336,"[""Calcium channel auxiliary subunit 1-8 (cca) family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400336,,,,,,,,,,,,,,,,,,,,,,,,,,,,Calcium channel auxiliary subunit 1-8 (cca) family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5514,"[""breast squamous cell carcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4680|http://purl.obolibrary.org/obo/DOID_1749,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5514,,,DOID:7300,NCI:C5177|UMLS_CUI:C1336079,SCC of breast|breast primary squamous cell carcinoma|primary squamous cell carcinoma of the breast,,disease_ontology,squamous cell carcinoma of breast|primary squamous cell carcinoma of breast,DOID:5514,,,,,,,,,,,,,,,,,,,breast squamous cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200189,"[""IPMK gene""]",,"This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19. [provided by RefSeq, Dec 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03491019,,,,,,,,"This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19. [provided by RefSeq, Dec 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200189,,,,,,,,,,,,,,,,253430,IPMK,IMPK,,,,,,,,,,IPMK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050581,"[""brachydactyly""]",,A bone development disease characterized by short fingers and toes.,false,,,http://purl.obolibrary.org/obo/DOID_1934,,,,,,,,A bone development disease characterized by short fingers and toes.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050581,,,,OMIM:112500|OMIM:113200|OMIM:113100|OMIM:613382|OMIM:112910|OMIM:112800|OMIM:607004|OMIM:113000|OMIM:113300|OMIM:615072|OMIM:112600|OMIM:301940|OMIM:112700|OMIM:112450|OMIM:611377|OMIM:112440|ORDO:294937,,,disease_ontology,,DOID:0050581,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,brachydactyly,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050580,"[""hereditary lymphedema""]",,"A lymphedema commonly located_in legs, caused_by congenital abnormalities in the lymphatic system.",false,,,http://purl.obolibrary.org/obo/DOID_4977,,,,,,,,"A lymphedema commonly located_in legs, caused_by congenital abnormalities in the lymphatic system.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050580,,,,OMIM:153100|SNOMEDCT_US_2016_03_01:75127007|OMIM:613480|OMIM:611944|SNOMEDCT_US_2016_03_01:205546005|SNOMEDCT_US_2016_03_01:205543002|SNOMEDCT_US_2016_03_01:205542007|ORDO:79452|OMIM:247440|UMLS_CUI:C1313885|OMIM:615907|OMIM:153200|ICD9CM:757.0,Milroy's disease|Nonne-Milroy lymphedema,,disease_ontology,,DOID:0050580,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,hereditary lymphedema,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050585,"[""congenital generalized lipodystrophy""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_811,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050585,,,,OMIM:608594|OMIM:612526|OMIM:269700|OMIM:613327,Beradinelli-Seip syndrome,,disease_ontology,,DOID:0050585,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,congenital generalized lipodystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050589,"[""inflammatory bowel disease""]",,An intestinal disease characterized by inflammation located_in all parts of digestive tract.,false,,,http://purl.obolibrary.org/obo/DOID_5295,,,,,,,,An intestinal disease characterized by inflammation located_in all parts of digestive tract.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050589,,,,SNOMEDCT_US_2016_03_01:24526004|SNOMEDCT_US_2016_03_01:196974002|KEGG:05321|MESH:D015212|OMIM:PS266600|SNOMEDCT_US_2016_03_01:155759008|SNOMEDCT_US_2016_03_01:266516008|UMLS_CUI:C0021390|EFO:0003767|NCI:C3138,,,disease_ontology,,DOID:0050589,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,inflammatory bowel disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200459,"[""ROR1 gene""]",,"This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400219,,,,,,,,"This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200459,,,,,,,,,,,,,,,,4919,ROR1,NTRKR1,,,,,,,,,,ROR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000402,"[""THR790 in EGFR(L858R,T790M)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000402,,,,,,,,,,,,,,,,,,,,,,,,,,,,"THR790 in EGFR(L858R,T790M)",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000364,"[""THR539 in TNNI3K""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000364,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR539 in TNNI3K,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100027,"[""Alpha-1a adrenergic receptor""]",,"An alpha-1A adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35348] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300093,,,,,,,,"An alpha-1A adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35348] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100027,,,,https://pharos.nih.gov/idg/targets/P35348,,,,,,,,,,,,,ADRA1A,ADRA1C,,P35348,,,,,,,,Alpha-1a adrenergic receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5212,"[""congenital disorder of glycosylation""]",,A carbohydrate metabolic disorder that involves deficient or defective glycosylation of a variety of tissue proteins and/or lipids.,false,,,http://purl.obolibrary.org/obo/DOID_2978,,,,,,,,A carbohydrate metabolic disorder that involves deficient or defective glycosylation of a variety of tissue proteins and/or lipids.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5212,,,,MESH:D018981|NCI:C84615|SNOMEDCT_US_2016_03_01:238049009|OMIM:212066|ORDO:137|OMIM:PS212065|UMLS_CUI:C0282577,carbohydrate-deficient glycoprotein syndrome,,disease_ontology,,DOID:5212,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,congenital disorder of glycosylation,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100291,"[""Olfactory receptor 10a5""]",,"An olfactory receptor 10A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H207] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10A5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H207] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100291,,,,https://pharos.nih.gov/idg/targets/Q9H207,,,,,,,,,,,,,OR10A5,OR10A1,,Q9H207,,,,,,,,Olfactory receptor 10a5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001410,"[""GH3 cell""]",,"Rat pituitary tumor, derived in 1965 from a pituitary tumor induced in a female Wistar/Furth rat ollowing repeated transplantation with the MtT/W5 tumor (originally induced in a female F/Fu rat by cranial X-irradiation).",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000756,,,,,,,,"Rat pituitary tumor, derived in 1965 from a pituitary tumor induced in a female Wistar/Furth rat ollowing repeated transplantation with the MtT/W5 tumor (originally induced in a female F/Fu rat by cranial X-irradiation).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001410,,,,,,,BrendaTissueOBO,,BTO:0001410,,,,,,,,,,,,,,,,,,,GH3 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1521,"[""cecum cancer""]",,A large intestine cancer that is located_in the cecum.,false,,,http://purl.obolibrary.org/obo/DOID_5672,,,,,,,,A large intestine cancer that is located_in the cecum.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1521,,,,MESH:D002430|UMLS_CUI:C0153437|SNOMEDCT_US_2016_03_01:187756005|ICD10CM:C18.0|SNOMEDCT_US_2016_03_01:93736007|SNOMEDCT_US_2016_03_01:154459000|NCI:C9329|SNOMEDCT_US_2016_03_01:363350007|SNOMEDCT_US_2016_03_01:269538009|ICD9CM:153.4,malignant tumor of the cecum|malignant neoplasm of caecum,,disease_ontology,,DOID:1521,,,,,,,,,,,,,,,,,,,cecum cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000078,"[""LEU603 in TYRO3""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000078,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU603 in TYRO3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200600,"[""CKMT1A gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200600,,,,,,,,,,,,,,,,,,,,,,,,,,,,CKMT1A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200369,"[""OR2T11 gene""]",,"An olfactory receptor 2T11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH01] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2T11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH01] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200369,,,,,,,,,,,,,,,,127077,OR2T11,,,,,,,,,,,OR2T11 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000510,"[""hindgut""]",,The caudal portion of the embryonic alimentary canal in vertebrates.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The caudal portion of the embryonic alimentary canal in vertebrates.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000510,,,,,,,BrendaTissueOBO,,BTO:0000510,,,,,,,,,,,,,,,,,,,hindgut,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100250,"[""Mucolipin-2""]",,"A mucolipin-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZK6] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300575,,,,,,,,"A mucolipin-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZK6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100250,,,,https://pharos.nih.gov/idg/targets/Q8IZK6,,,,,,,,,,,,,MCOLN2,,,Q8IZK6,,,,,,,,Mucolipin-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000135,"[""MET154 in MRCKA""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000135,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET154 in MRCKA,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000302,"[""THR103 in SIK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000302,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR103 in SIK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400373,"[""Anion channel tweety (tweety) family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400373,,,,,,,,,,,,,,,,,,,,,,,,,,,,Anion channel tweety (tweety) family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060288,"[""omodysplasia""]",,NT MGI.,false,,,http://purl.obolibrary.org/obo/DOID_2256,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060288,emitraka,2015-02-05T09:58:47Z,,MESH:C537746|OMIM:164745|UMLS_CUI:C2750355|OMIM:258315|MESH:C567664|ORDO:2733|UMLS_CUI:C1850318,,,disease_ontology,,DOID:0060288,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,NT MGI.,,omodysplasia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060287,"[""cornea plana""]",,NT MGI.,false,,,http://purl.obolibrary.org/obo/DOID_10124,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060287,emitraka,2015-02-04T17:04:28Z,,OMIM:121400|ORDO:53691|OMIM:217300|HP:0007720|ICD10CM:Q13.4,flat cornea,,disease_ontology,,DOID:0060287,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,NT MGI.,,cornea plana,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060282,"[""persistent hyperplastic primary vitreous""]",,NT MGI.,false,,,http://purl.obolibrary.org/obo/DOID_9720,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060282,emitraka,2015-02-04T16:21:06Z,,OMIM:221900|UMLS_CUI:C0266568|ORDO:91495|SNOMEDCT_US_2016_03_01:44647001|SNOMEDCT_US_2016_03_01:314270008|OMIM:611308|MESH:D054514|SNOMEDCT_US_2016_03_01:69927002,,,disease_ontology,,DOID:0060282,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,NT MGI.,,persistent hyperplastic primary vitreous,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060281,"[""photosensitive epilepsy""]",,"An epilepsy characterized by seizures triggered by visual stimuli that form patterns in space or time, such as flashing lights.",false,,,http://purl.obolibrary.org/obo/DOID_1826,,,,,,,,"An epilepsy characterized by seizures triggered by visual stimuli that form patterns in space or time, such as flashing lights.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060281,emitraka,2015-02-04T16:15:55Z,,ORDO:166409|OMIM:132100|ICD10CM:G40.8|OMIM:609572|OMIM:609573,photoparoxysmal response|photogenic epilepsy,,disease_ontology,,DOID:0060281,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,NT MGI.,,photosensitive epilepsy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3443,"[""mammary Paget's disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3458,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3443,,,,UMLS_CUI:C1368019|NCI:C7073,Paget cell neoplasm|Paget's disease|Paget's disease of the breast |mammary Paget disease,,disease_ontology,,DOID:3443,,,,,,,,,,,,,,,,,,,mammary Paget's disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_15558,"[""15(S)-HETE""]","(5Z,8Z,11Z,13E,15S)-15-hydroxy-5,8,11,13-eicosatetraenoic acid|(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate|(5Z,8Z,11Z,13E)-(15S)-15-Hydroxyicosa-5,8,11,13-tetraenoic acid|(15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate|320.46628|15S-HETE|320.235|(5Z,8Z,11Z,13E,15S)-15-hydroxyeicosa-5,8,11,13-tetraenoic acid|(15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate|icomucret|InChI=1S/C20H32O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h4-5,8-11,14,17,19,21H,2-3,6-7,12-13,15-16,18H2,1H3,(H,22,23)/b5-4-,10-8-,11-9-,17-14+/t19-/m0/s1|CCCCC[C@H](O)\C=C\C=C/C\C=C/C\C=C/CCCC(O)=O|(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid|(15S)-15-hydroxy-5,8,11-cis-13-trans-eicosatetraenoate|15(S)-hydroxyeicosatetraenoic acid|0|JSFATNQSLKRBCI-VAEKSGALSA-N|(15S)-hydroxyeicosa-(5Z,8Z,11Z,13E)-tetraenoic acid|C20H32O3",An optically active form of 15-HETE having 15(S)-configuration..,false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,HMDB:HMDB03876|PMID:22068350|PMID:18494609|PMID:11212240|PMID:15613483|Reaxys:6125815|KEGG:D08931|CAS:54845-95-3|Beilstein:2470466|LIPID_MAPS_instance:LMFA03060001|KEGG:C04742|PMID:15964853,An optically active form of 15-HETE having 15(S)-configuration..,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:10824|CHEBI:18507|CHEBI:147,,"(5Z,8Z,11Z,13E,15S)-15-hydroxyicosa-5,8,11,13-tetraenoic acid|15(S)-HETE",,chebi_ontology,"(5Z,8Z,11Z,13E,15S)-15-hydroxy-5,8,11,13-eicosatetraenoic acid|(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate|(5Z,8Z,11Z,13E)-(15S)-15-Hydroxyicosa-5,8,11,13-tetraenoic acid|(15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate|320.46628|15S-HETE|320.235|(5Z,8Z,11Z,13E,15S)-15-hydroxyeicosa-5,8,11,13-tetraenoic acid|(15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate|icomucret|InChI=1S/C20H32O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h4-5,8-11,14,17,19,21H,2-3,6-7,12-13,15-16,18H2,1H3,(H,22,23)/b5-4-,10-8-,11-9-,17-14+/t19-/m0/s1|CCCCC[C@H](O)\C=C\C=C/C\C=C/C\C=C/CCCC(O)=O|(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid|(15S)-15-hydroxy-5,8,11-cis-13-trans-eicosatetraenoate|15(S)-hydroxyeicosatetraenoic acid|0|JSFATNQSLKRBCI-VAEKSGALSA-N|(15S)-hydroxyeicosa-(5Z,8Z,11Z,13E)-tetraenoic acid|C20H32O3",,,CHEBI:15558,,,,,,,,,,,,,,,,,,,,,,,CHEBI:15558,,,,,15(S)-HETE,,CHEBI:15558,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100296,"[""Mitogen-activated protein kinase kinase kinase kinase 4""]",,"mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase kinase kinase kinase 4 that is encoded in the genome of human. [PRO:AL, UniProtKB:O95819] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300288,,,,,,,,"mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)  with  no mutation  in a nonphosphorylated state|A mitogen-activated protein kinase kinase kinase kinase 4 that is encoded in the genome of human. [PRO:AL, UniProtKB:O95819] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100296,,,,https://pharos.nih.gov/idg/targets/O95819,,,,,,,,,,,,,MAP4K4,HGK|KIAA0687|NIK,,O95819,,,,,,,,Mitogen-activated protein kinase kinase kinase kinase 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003393,"[""granule cell""]",,"In neuroscience, granule cells refer to tiny neurons (a type of cell) that are around 10 micrometres in diameter. Granule cells are found within the granular layer of the cerebellum, layer 4 of cerebral cortex, the dentate gyrus of the hippocampus, and in the olfactory bulb.",false,,,http://purl.obolibrary.org/obo/BTO_0000938|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"In neuroscience, granule cells refer to tiny neurons (a type of cell) that are around 10 micrometres in diameter. Granule cells are found within the granular layer of the cerebellum, layer 4 of cerebral cortex, the dentate gyrus of the hippocampus, and in the olfactory bulb.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003393,,,,,,,BrendaTissueOBO,,BTO:0003393,,,,,,,,,,,,,,,,,,,granule cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004416,"[""Daltons lymphoma cell""]",,Spontaneous T cell lymphoma.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001825,,,,,,,,Spontaneous T cell lymphoma.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004416,Marion,2010-02-01T01:24:28Z,,,,,BrendaTissueOBO,Dalton's lymphoma cell,BTO:0004416,,,,,,,,,,,,,,,,,,,Daltons lymphoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100009,"[""Activin receptor type-1b""]",,"An activin receptor type-1B that is encoded in the genome of human. [PRO:CNA, UniProtKB:P36896] |activin receptor type-1b (ACVR1B)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300246,,,,,,,,"An activin receptor type-1B that is encoded in the genome of human. [PRO:CNA, UniProtKB:P36896] |activin receptor type-1b (ACVR1B)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100009,,,,https://pharos.nih.gov/idg/targets/P36896,,,,,,,,,,,,,ACVR1B,ACVRLK4|ALK4,,P36896,,,,,,,,Activin receptor type-1b,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100240,"[""Lysophosphatidic acid receptor 3""]",,"A lysophosphatidic acid receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UBY5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302007,,,,,,,,"A lysophosphatidic acid receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UBY5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100240,,,,https://pharos.nih.gov/idg/targets/Q9UBY5,,,,,,,,,,,,,LPAR3,EDG7|LPA3,,Q9UBY5,,,,,,,,Lysophosphatidic acid receptor 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5199,"[""ureteral obstruction""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1426|http://purl.obolibrary.org/obo/DOID_5200,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5199,,,,ICD9CM:593.4|UMLS_CUI:C0029866|SNOMEDCT_US_2016_03_01:197807001,,,disease_ontology,,DOID:5199,,,,,,,,,,,,,,,,,,,ureteral obstruction,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002896,"[""HM-1 ES cell""]",,Murine embryonic stem cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001581,,,,,,,,Murine embryonic stem cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002896,,,,,,,BrendaTissueOBO,HM-1 cell,BTO:0002896,,,,,,,,,,,,,,,,,,,HM-1 ES cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000391,"[""DLD-1 cell""]",,Human colon adenocarcinoma established from a colorectal adenocarcinoma.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001913,,,,,,,,Human colon adenocarcinoma established from a colorectal adenocarcinoma.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000391,,,,,,,BrendaTissueOBO,,BTO:0000391,,,,,,,,,,,,,,,,,,,DLD-1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000720,"[""plant form""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001461,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000720,,,,,,,BrendaTissueOBO,,BTO:0000720,,,,,,,,,,,,,,,,,,,plant form,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200003,"[""HTR3C gene""]",,"The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit C of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. Genes encoding subunits C, D and E form a cluster on chromosome 3. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01409932,,,,,,,,"The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit C of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. Genes encoding subunits C, D and E form a cluster on chromosome 3. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200003,,,,,,,,,,,,,,,,170572,HTR3C,,,,,,,,,,,HTR3C gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002290,"[""primary cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002290,,,,,,,BrendaTissueOBO,,BTO:0002290,,,,,,,,,,,,,,,,,,,primary cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200009,"[""ACVR1B gene""]",,"This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400246,,,,,,,,"This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200009,,,,,,,,,,,,,,,,91,ACVR1B,ACVRLK4|ALK4,,,,,,,,,,ACVR1B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001191,"[""root tip""]",,The root tip is the tip of the root and contains the root cap and the apical meristem -the actively growing region.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The root tip is the tip of the root and contains the root cap and the apical meristem -the actively growing region.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001191,,,,,,,BrendaTissueOBO,,BTO:0001191,,,,,,,,,,,,,,,,,,,root tip,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200434,"[""OR52P1P gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200434,,,,,,,,,,,,,,,,81248,OR52P1P,OR52P1,,,,,,,,,,OR52P1P gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000002,"[""CCL19""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000002,,,,,,,,,,,,,,,,,,,,,,,,,,,,CCL19,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200316,"[""MAPK3 gene""]",,"The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400292,,,,,,,,"The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200316,,,,,,,,,,,,,,,,5595,MAPK3,ERK1|PRKM3,,,,,,,,,,MAPK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400100,"[""P2Y receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400053,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400100,,,,,,,,,,,,,,,,,,,,,,,,,,,,P2Y receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200812,"[""TAS1R3 gene""]",,"A taste receptor type 1 member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7RTX0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400015,,,,,,,,"A taste receptor type 1 member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7RTX0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200812,,,,,,,,,,,,,,,,83756,TAS1R3,T1R3|TR3,,,,,,,,,,TAS1R3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100407,"[""Olfactory receptor 51V1""]",,"An olfactory receptor 51V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H2C8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 51V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H2C8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100407,,,,https://pharos.nih.gov/idg/targets/Q9H2C8,,,,,,,,,,,,,OR51V1,OR51A12,,Q9H2C8,,,,,,,,Olfactory receptor 51V1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300393,"[""CLCNKA subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300341,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300393,,,,,,,,,,,,,,,,,,,,,,,,,,,,CLCNKA subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100585,"[""Olfactory receptor 4E2""]",,"An olfactory receptor 4E2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4E2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100585,,,,https://pharos.nih.gov/idg/targets/Q8NGC2,,,,,,,,,,,,,OR4E2,,,Q8NGC2,,,,,,,,Olfactory receptor 4E2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200710,"[""OR8U9 gene""]",,"An olfactory receptor 8U9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7N5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 8U9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C7N5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200710,,,,,,,,,,,,,,,,504190,OR8U9,,,,,,,,,,,OR8U9 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1682,"[""congenital heart disease""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_114,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1682,,,,SNOMEDCT_US_2016_03_01:156926008|MESH:D006330|SNOMEDCT_US_2016_03_01:204413006|UMLS_CUI:C0018798|SNOMEDCT_US_2016_03_01:13213009|SNOMEDCT_US_2016_03_01:268315002|ICD9CM:746.9|SNOMEDCT_US_2016_03_01:156911006|SNOMEDCT_US_2016_03_01:204405005|NCI:C34666|SNOMEDCT_US_2016_03_01:268318000|ICD10CM:Q24.9,congenital heart defect|Heart Malformation|Congenital anomaly of heart|Congenital Heart Defects|heart defect,,disease_ontology,Heart-congenital defect,DOID:1682,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,congenital heart disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12804,"[""mucopolysaccharidosis IV""]",,A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzymes galactose 6-sulfate sulfatase (Type A) or beta-galactosidase (Type B) needed to break down the keratan sulfate sugar chain.,false,,,http://purl.obolibrary.org/obo/DOID_12798,,,,,,,,A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzymes galactose 6-sulfate sulfatase (Type A) or beta-galactosidase (Type B) needed to break down the keratan sulfate sugar chain.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12804,,,DOID:14767,UMLS_CUI:C0026707|SNOMEDCT_US_2016_03_01:124449003|NCI:C84901|SNOMEDCT_US_2016_03_01:254074007|ICD10CM:E76.210|OMIM:253010|ICD10CM:E76.219|SNOMEDCT_US_2016_03_01:130197005|MESH:D009085|SNOMEDCT_US_2016_03_01:190936000|OMIM:253000|SNOMEDCT_US_2016_03_01:378007|SNOMEDCT_US_2016_03_01:78856008|UMLS_CUI:C0086651|NCI:C61263|SNOMEDCT_US_2016_03_01:7259005,"galactosamine-6-sulfatase deficiency|Mucopolysaccharidosis, MPS-IV|deficiency of chondroitinsulphatase|deficiency of N-acetylgalactosamine-6-sulphatase","mucopolysaccharidosis type IVA|MPS IV - Morquio syndrome B|chondroosteodystrophy|Mucopolysaccharidosis, MPS-IV-A (disorder)|Morquio syndrome A|Osteochondrodystrophy|Mucopolysaccharidosis type IVB|Morquio A disease|MPS IV - Morquio syndrome A",disease_ontology,,DOID:12804,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,mucopolysaccharidosis IV,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12800,"[""mucopolysaccharidosis VI""]",,A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme N-acetylgalactosamine 4-sulfatase.,false,,,http://purl.obolibrary.org/obo/DOID_12798,,,,,,,,A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme N-acetylgalactosamine 4-sulfatase.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12800,,,,OMIM:253200|SNOMEDCT_US_2016_03_01:69463008|MESH:D009087|SNOMEDCT_US_2016_03_01:190936000|NCI:C61264|SNOMEDCT_US_2016_03_01:52677002|UMLS_CUI:C0026709,Maroteaux - Lamy syndrome|MPS VI - Maroteaux-Lamy syndrome|arylsulfatase B deficiency|deficiency of N-acetylgalactosamine-4-sulfatase (disorder)|Maroteaux-Lamy syndrome,,disease_ontology,,DOID:12800,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,mucopolysaccharidosis VI,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050696,"[""fetal alcohol spectrum disorder""]",,"A specific developmental disorder and physical disorder that is characterized by physical, behavioral and learning birth defects resulting from maternal ingestion of alcohol during pregnancy.",false,,,http://purl.obolibrary.org/obo/DOID_0060038,,,,,,,,"A specific developmental disorder and physical disorder that is characterized by physical, behavioral and learning birth defects resulting from maternal ingestion of alcohol during pregnancy.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050696,lschriml,2011-12-01T01:01:25Z,,,,,disease_ontology,,DOID:0050696,,,,,,,,,,,,,,,,,,,fetal alcohol spectrum disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050699,"[""Dent disease""]",,"A renal tubular transport disease that is characterized by  tubular proteinuria, hypercalciuria, calcium nephrolithiasis, nephrocalcinosis and chronic kidney failure and has_material_basis_in X-linked recessive inheritance of mutations in the CLCN5 gene or OCRL1 gene.",false,,,http://purl.obolibrary.org/obo/DOID_447,,,,,,,,"A renal tubular transport disease that is characterized by  tubular proteinuria, hypercalciuria, calcium nephrolithiasis, nephrocalcinosis and chronic kidney failure and has_material_basis_in X-linked recessive inheritance of mutations in the CLCN5 gene or OCRL1 gene.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050699,lschriml,2015-03-12T14:32:47Z,,ORDO:1652|UMLS_CUI:C0878681|OMIM:300555|OMIM:300009|UMLS_CUI:C1845167|MESH:C538212|MESH:C564487|UMLS_CUI:C1848336|SNOMEDCT_US_2016_03_01:444645005|NCI:C123260|MESH:D057973,Dent disease 2|Dent disease 1|Dent's disease,,disease_ontology,,DOID:0050699,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,Dent disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000051,"[""BMPR1B kinase domain""]",,"Bone morphogenetic protein receptor, type IB; ALK6; ALK-6; BMPR1B; CDw293",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Bone morphogenetic protein receptor, type IB; ALK6; ALK-6; BMPR1B; CDw293",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000051,,,,,,,,,,,,,,,,,,,200051,,,,,,,,,BMPR1B kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100620,"[""Olfactory receptor 5d14""]",,"An olfactory receptor 5D14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5D14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100620,,,,https://pharos.nih.gov/idg/targets/Q8NGL3,,,,,,,,,,,,,OR5D14,,,Q8NGL3,,,,,,,,Olfactory receptor 5d14,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200231,"[""KCNN4 gene""]",,"The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400437,,,,,,,,"The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200231,,,,,,,,,,,,,,,,3783,KCNN4,IK1|IKCA1|KCA4|SK4,,,,,,,,,,KCNN4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200321,"[""OR10R2 gene""]",,"An olfactory receptor 10R2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10R2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200321,,,,,,,,,,,,,,,,343406,OR10R2,,,,,,,,,,,OR10R2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200155,"[""GPR152 gene""]",,"A G-protein coupled receptor 152 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDT2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400052,,,,,,,,"A G-protein coupled receptor 152 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDT2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200155,,,,,,,,,,,,,,,,390212,GPR152,PGR5,,,,,,,,,,GPR152 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4897,"[""bile duct carcinoma""]",,A bile duct cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.,false,,,http://purl.obolibrary.org/obo/DOID_305|http://purl.obolibrary.org/obo/DOID_4606,,,,,,,,A bile duct cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4897,,,,MESH:D001650|SNOMEDCT_US_2016_03_01:70179006|NCI:C27814|UMLS_CUI:C0740277,,,disease_ontology,,DOID:4897,,,,,,,,,,,,,,,,,,,bile duct carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200026,"[""AMHR2 gene""]",,"This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400252,,,,,,,,"This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200026,,,,,,,,,,,,,,,,269,AMHR2,AMHR|MISR2,,,,,,,,,,AMHR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001221,"[""sciatic nerve""]",,"The largest nerve of the body: origin, sacral plexus-L4-S3; it leaves the pelvis through the greater sciatic foramen; branches, divides into the tibial and common peroneal nerves, usually in lower third of thigh; distribution-see individual branches, in this table; modality, general sensory and motor.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000925,,,,,,,,"The largest nerve of the body: origin, sacral plexus-L4-S3; it leaves the pelvis through the greater sciatic foramen; branches, divides into the tibial and common peroneal nerves, usually in lower third of thigh; distribution-see individual branches, in this table; modality, general sensory and motor.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001221,,,,,,,BrendaTissueOBO,nervus sciaticus|nervus ischiadicus,BTO:0001221,,,,,,,,,,,,,,,,,,,sciatic nerve,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001530,"[""glioblastoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000101,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001530,,,,,,,BrendaTissueOBO,,BTO:0001530,,,,,,,,,,,,,,,,,,,glioblastoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100578,"[""Probable gluconokinase""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100578,,,,,,,,,,,,,,,,,IDNK,,,Q5T6J7,,,,,,,,Probable gluconokinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000216,"[""culture condition""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000216,,,,,,,BrendaTissueOBO,,BTO:0000216,,,,,,,,,,,,,,,,,,,culture condition,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100777,"[""Taste receptor type 2 member 13""]",,"A taste receptor type 2 member 13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYV9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300014,,,,,,,,"A taste receptor type 2 member 13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYV9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100777,,,,https://pharos.nih.gov/idg/targets/Q9NYV9,,,,,,,,,,,,,TAS2R13,,,Q9NYV9,,,,,,,,Taste receptor type 2 member 13,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200633,"[""OR5K4 gene""]",,"An olfactory receptor 5K4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NMS3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5K4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NMS3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200633,,,,,,,,,,,,,,,,403278,OR5K4,,,,,,,,,,,OR5K4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200085,"[""CNGA1 gene""]",,"The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400402,,,,,,,,"The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200085,,,,,,,,,,,,,,,,1259,CNGA1,CNCG|CNCG1,,,,,,,,,,CNGA1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000262,"[""clove""]",,One of the small bulbs (as in garlic) developed in the axils of the scales of a large bulb.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000159,,,,,,,,One of the small bulbs (as in garlic) developed in the axils of the scales of a large bulb.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000262,,,,,,,BrendaTissueOBO,,BTO:0000262,,,,,,,,,,,,,,,,,,,clove,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100340,"[""Dual specificity mitogen-activated protein kinase kinase 7""]",,"dual specificity mitogen-activated protein kinase kinase 7 (MP2K7)  with  no mutation  in a nonphosphorylated state|A dual specificity mitogen-activated protein kinase kinase 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14733] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300194,,,,,,,,"dual specificity mitogen-activated protein kinase kinase 7 (MP2K7)  with  no mutation  in a nonphosphorylated state|A dual specificity mitogen-activated protein kinase kinase 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14733] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100340,,,,https://pharos.nih.gov/idg/targets/O14733,,,,,,,,,,,,,MAP2K7,JNKK2|MEK7|MKK7|PRKMK7|SKK4,,O14733,,,,,,,,Dual specificity mitogen-activated protein kinase kinase 7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_15746,"[""spermine""]","C10H26N4|PFNFFQXMRSDOHW-UHFFFAOYSA-N|N,N'-Bis(3-aminopropyl)-1,4-butanediamine|4,9-diazadodecane-1,12-diamine|NCCCNCCCCNCCCN|202.216|4,9-diaza-1,12-dodecanediamine|InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2|0|202.34040","A polyazaalkane that is tetradecane in which the carbons at positions 1, 5, 10 and 14 are replaced by nitrogens. Spermine has broad actions on cellular metabolism.",false,,,http://purl.obolibrary.org/obo/CHEBI_32952,,,,,,,PMID:15145762|PMID:8524182|PMID:16253230|PMID:10873205|PMID:19593412|PMID:23506248|PMID:15972654|HMDB:HMDB01256|DrugBank:DB00127|Reaxys:1750791|PMID:7721849|PMID:15308338|PDBeChem:SPM|PMID:23418509|PMID:16146631|MetaCyc:SPERMINE|PMID:11341774|PMID:11543598|PMID:19962967|PMID:9151701|PMID:23820617|PMID:23289636|PMID:11805860|PMID:23887925|PMID:22735334|Gmelin:454653|PMID:7521253|PMID:10930630|PMID:15500473|PMID:19275753|KNApSAcK:C00001432|PMID:16664713|Beilstein:1750791|PMID:8832899|CAS:71-44-3|KEGG:C00750|Wikipedia:Spermine,"A polyazaalkane that is tetradecane in which the carbons at positions 1, 5, 10 and 14 are replaced by nitrogens. Spermine has broad actions on cellular metabolism.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:45583|CHEBI:15098|CHEBI:9219|CHEBI:26734,,"N,N'-bis(3-aminopropyl)butane-1,4-diamine|SPERMINE|Spermine",,chebi_ontology,"C10H26N4|PFNFFQXMRSDOHW-UHFFFAOYSA-N|N,N'-Bis(3-aminopropyl)-1,4-butanediamine|4,9-diazadodecane-1,12-diamine|NCCCNCCCCNCCCN|202.216|4,9-diaza-1,12-dodecanediamine|InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2|0|202.34040",,,CHEBI:15746,,,,,,,,,,,,,,,,,,,,,,,CHEBI:15746,,,,,spermine,,CHEBI:15746,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100042,"[""P576 in KIT(L576P)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100042,,,,,,,,,,,,,,,,,,,,,,,,,,,,P576 in KIT(L576P),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_3165,"[""bradykinin""]","Callidin I|Kallidin 9|BK|
InChI=1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
|Kallidin I|C50H73N15O11|
N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
|
L-Arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-Arginine
|QXZGBUJJYSLZLT-FDISYFBBSA-N|L-bradykinin|
(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-(2-{[(2S)-1-{[(2S)-1-[(2S)-2-amino-5-carbamimidamidopentanoyl]pyrrolidin-2-yl]carbonyl}pyrrolidin-2-yl]formamido}acetamido)-3-phenylpropanamido]-3-hydroxypropanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanamido]-5-carbamimidamidopentanoic acid
","
A linear nonapeptide messenger belonging to the kinin group of proteins, with amino acid sequence RPPGFSPFR. Enzymatically produced from kallidin in the blood, it is a powerful vasodilator that causes smooth muscle contraction, and may mediate inflammation.
",false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,ChemIDplus:58-82-2|CiteXplore:19212411|HMDB:HMDB04246|CiteXplore:11975815|KEGG COMPOUND:C00306|CiteXplore:18127230|CiteXplore:13446366,"
A linear nonapeptide messenger belonging to the kinin group of proteins, with amino acid sequence RPPGFSPFR. Enzymatically produced from kallidin in the blood, it is a powerful vasodilator that causes smooth muscle contraction, and may mediate inflammation.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,"
L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-arginine
|Bradykinin",,chebi_ontology,"Callidin I|Kallidin 9|BK|
InChI=1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
|Kallidin I|C50H73N15O11|
N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
|
L-Arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-Arginine
|QXZGBUJJYSLZLT-FDISYFBBSA-N|L-bradykinin|
(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-(2-{[(2S)-1-{[(2S)-1-[(2S)-2-amino-5-carbamimidamidopentanoyl]pyrrolidin-2-yl]carbonyl}pyrrolidin-2-yl]formamido}acetamido)-3-phenylpropanamido]-3-hydroxypropanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanamido]-5-carbamimidamidopentanoic acid
",,,CHEBI:3165,,,,,,,,,,,,,,,,,,,,,,,CHEBI:3165,,,,,bradykinin|Bradykinin,,CHEBI:3165,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200014,"[""CHRNA1 gene""]",,"The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha subunits and 1 each of the beta, gamma, and delta subunits. This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Nov 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_01400498,,,,,,,,"The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha subunits and 1 each of the beta, gamma, and delta subunits. This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Nov 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200014,,,,,,,,,,,,,,,,1134,CHRNA1,ACHRA|CHNRA,,,,,,,,,,CHRNA1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000368,"[""ear""]",,The organ of hearing.,false,,,http://purl.obolibrary.org/obo/BTO_0000202|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The organ of hearing.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000368,,,,,,,BrendaTissueOBO,auditory apparatus|auris|auditory system,BTO:0000368,,,,,,,,,,,,,,,,,,,ear,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000287,"[""MP2K2 kinase domain""]",,Dual specificity mitogen-activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2; FLJ26075; MAP2K2; MAPKK2; MEK2; MEK2/MAP2K2; MKK2; PRKMK2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Dual specificity mitogen-activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2; FLJ26075; MAP2K2; MAPKK2; MEK2; MEK2/MAP2K2; MKK2; PRKMK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000287,,,,,,,,,,,,,,,,,,,200252,,,,,,,,,MP2K2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000109,"[""bacteroid""]",,An irregularly shaped bacterium (as a rhizobium) found especially in root nodules of legumes.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000284,,,,,,,,An irregularly shaped bacterium (as a rhizobium) found especially in root nodules of legumes.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000109,,,,,,,BrendaTissueOBO,,BTO:0000109,,,,,,,,,,,,,,,,,,,bacteroid,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200294,"[""SCN3B gene""]",,"Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400468,,,,,,,,"Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200294,,,,,,,,,,,,,,,,55800,SCN3B,KIAA1158,,,,,,,,,,SCN3B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100366,"[""Olfactory receptor 2AP1""]",,"An olfactory receptor 2AP1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2AP1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100366,,,,https://pharos.nih.gov/idg/targets/Q8NGE2,,,,,,,,,,,,,OR2AP1,OR2AP1P,,Q8NGE2,,,,,,,,Olfactory receptor 2AP1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300571,"[""KCa5.1/KCNU1 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300437,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300571,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCa5.1/KCNU1 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100109,"[""Diacylglycerol kinase theta""]",,"A diacylglycerol kinase theta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P52824] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391025,,,,,,,,"A diacylglycerol kinase theta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P52824] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100109,,,,https://pharos.nih.gov/idg/targets/P52824,,,,,,,,,,,,,DGKQ,DAGK4,,P52824,,,,,,,,Diacylglycerol kinase theta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2945,"[""severe acute respiratory syndrome""]",,"A viral infectious disease that results_in infection located_in respiratory tract, has_material_basis_in SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom dry cough, and has_symptom hypoxia.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in infection located_in respiratory tract, has_material_basis_in SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom dry cough, and has_symptom hypoxia.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2945,,,,NCI:C85064|ICD10CM:J12.81|ICD9CM:079.82|SNOMEDCT_US_2016_03_01:398447004|MESH:D045169|UMLS_CUI:C1175175,SARS|SARS-CoV infection,,disease_ontology,,DOID:2945,http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,severe acute respiratory syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9892,"[""median arcuate ligament syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0050828|http://purl.obolibrary.org/obo/DOID_225,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9892,,,,ICD9CM:447.4|ICD10CM:I77.4|UMLS_CUI:C0152098|SNOMEDCT_US_2016_03_01:9250002,Harjola-Marable syndrome|Celiac artery compression syndrome|Marable's syndrome,,disease_ontology,,DOID:9892,,,,,,,,,,,,,,,,,,,median arcuate ligament syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000522,"[""gland""]",,"A cell, group of cells, or organ of endothelial origin that selectively removes materials from the blood, concentrates or alters them, and secretes them for further use in the body or for elimination from the body.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A cell, group of cells, or organ of endothelial origin that selectively removes materials from the blood, concentrates or alters them, and secretes them for further use in the body or for elimination from the body.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000522,,,,,,,BrendaTissueOBO,Druese|glandula,BTO:0000522,,,,,,,,,,,,,,,,,,,gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100405,"[""Phosphoglycerate kinase 1""]",,"A phosphoglycerate kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00558] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391013,,,,,,,,"A phosphoglycerate kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00558] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100405,,,,https://pharos.nih.gov/idg/targets/P00558,,,,,,,,,,,,,PGK1,PGKA,,P00558,,,,,,,,Phosphoglycerate kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200258,"[""MRGPRE gene""]",,"A mas-related G-protein coupled receptor E that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86SM8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400063,,,,,,,,"A mas-related G-protein coupled receptor E that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86SM8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200258,,,,,,,,,,,,,,,,116534,MRGPRE,GPR167|MRGE,,,,,,,,,,MRGPRE gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300535,"[""Kv1.4/KCNA4 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300436,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300535,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv1.4/KCNA4 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200078,"[""CXCR4 gene""]",,"A C-X-C chemokine receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P61073] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400097,,,,,,,,"A C-X-C chemokine receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P61073] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200078,,,,,,,,,,,,,,,,7852,CXCR4,,,,,,,,,,,CXCR4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100639,"[""Olfactory receptor 5M9""]",,"An olfactory receptor 5M9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5M9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100639,,,,https://pharos.nih.gov/idg/targets/Q8NGP3,,,,,,,,,,,,,OR5M9,,,Q8NGP3,,,,,,,,Olfactory receptor 5M9,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100599,"[""Creatine kinase B-type""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100599,,,,,,,,,,,,,,,,,CKB,,,P12277,,,,,,,,Creatine kinase B-type,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200617,"[""PCK1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200617,,,,,,,,,,,,,,,,,,,,,,,,,,,,PCK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000449,"[""TYK2(JH1domain-catalytic) kinase domain""]",,Non-receptor tyrosine-protein kinase TYK2; Tyrosine kinase 2; JTK1; TYK2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Non-receptor tyrosine-protein kinase TYK2; Tyrosine kinase 2; JTK1; TYK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000449,,,,,,,,,,,,,,,,,,,"200450, 200452",,,,,,,,,TYK2(JH1domain-catalytic) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300315,"[""SLK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300187,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300315,,,,,,,,,,,,,,,,,,,,,,,,,,,,SLK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300316,"[""LKB subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300116,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300316,,,,,,,,,,,,,,,,,,,,,,,,,,,,LKB subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_7061,"[""precursor B lymphoblastic lymphoma/leukemia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5600|http://purl.obolibrary.org/obo/DOID_707,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:7061,,,,UMLS_CUI:C0862030|NCI:C8936,,,disease_ontology,,DOID:7061,,,,,,,,,,,,,,,,,,,precursor B lymphoblastic lymphoma/leukemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80295,"[""Urocortin I""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16080,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80295,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80295,,,,,Urocortin I,,CHEBI:80295,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2383,"[""neonatal jaundice""]",,"A pigmentation disease characterized by a high level of bilirubin in the blood, causing a yellowing of the skin and other tissues of a newborn infant.",false,,,http://purl.obolibrary.org/obo/DOID_10123,,,,,,,,"A pigmentation disease characterized by a high level of bilirubin in the blood, causing a yellowing of the skin and other tissues of a newborn infant.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2383,,,,ICD10CM:P59.9|SNOMEDCT_US_2016_03_01:31482007|SNOMEDCT_US_2016_03_01:111470007|MESH:D007567|SNOMEDCT_US_2016_03_01:276549000|SNOMEDCT_US_2016_03_01:30235009|SNOMEDCT_US_2016_03_01:299968002|SNOMEDCT_US_2016_03_01:206474007|SNOMEDCT_US_2016_03_01:387712008|NCI:C99246|UMLS_CUI:C0022353,neonatal hyperbilirubinemia|neonatal icterus,,disease_ontology,,DOID:2383,,,,,,,,,,,,,,,,,,,neonatal jaundice,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000204,"[""carotid body""]",,"A small cluster of chemoreceptive and supporting cells located near the bifurcation of the internal carotid artery. The carotid body, which is richly supplied with fenestrated capillaries, senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control.",false,,,http://purl.obolibrary.org/obo/BTO_0000202|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A small cluster of chemoreceptive and supporting cells located near the bifurcation of the internal carotid artery. The carotid body, which is richly supplied with fenestrated capillaries, senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000204,,,,,,,BrendaTissueOBO,,BTO:0000204,,,,,,,,,,,,,,,,,,,carotid body,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100574,"[""Olfactory receptor 4c13""]",,"An olfactory receptor 4C13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4C13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100574,,,,https://pharos.nih.gov/idg/targets/Q8NGP0,,,,,,,,,,,,,OR4C13,,,Q8NGP0,,,,,,,,Olfactory receptor 4c13,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100590,"[""Olfactory receptor 4k1""]",,"An olfactory receptor 4K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 4K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100590,,,,https://pharos.nih.gov/idg/targets/Q8NGD4,,,,,,,,,,,,,OR4K1,,,Q8NGD4,,,,,,,,Olfactory receptor 4k1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200117,"[""GABRE gene""]",,"The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants have been identified, but only one is thought to encode a protein. [provided by RefSeq, Oct 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400516,,,,,,,,"The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants have been identified, but only one is thought to encode a protein. [provided by RefSeq, Oct 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200117,,,,,,,,,,,,,,,,2564,GABRE,,,,,,,,,,,GABRE gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8566,"[""herpes simplex""]",,"A viral infectious disease that results_in_formation_of lesions, located_in mouth, located_in face, located_in genitalia, or located_in hands, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, which are transmitted_by direct contact with an active lesion or body fluid of an infected person.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in_formation_of lesions, located_in mouth, located_in face, located_in genitalia, or located_in hands, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, which are transmitted_by direct contact with an active lesion or body fluid of an infected person.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8566,,,DOID:9012|DOID:9239|DOID:8763,ICD10CM:B00.9|MESH:D006561|ICD9CM:054|UMLS_CUI:C0019348|ICD10CM:B00|SNOMEDCT_US_2016_03_01:186534002|SNOMEDCT_US_2016_03_01:154332007|SNOMEDCT_US_2016_03_01:88594005|SNOMEDCT_US_2016_03_01:266191005,Herpesvirus hominis disease,,disease_ontology,,DOID:8566,,,,,,,,,,,,,,,,,,,herpes simplex,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100045,"[""Voltage-dependent T-type calcium channel subunit alpha-1H""]",,"A voltage-dependent T-type calcium channel subunit alpha-1H that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95180] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300388,,,,,,,,"A voltage-dependent T-type calcium channel subunit alpha-1H that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95180] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100045,,,,https://pharos.nih.gov/idg/targets/O95180,,,,,,,,,,,,,CACNA1H,,,O95180,,,,,,,,Voltage-dependent T-type calcium channel subunit alpha-1H,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200178,"[""GCK gene""]",,"Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03491017,,,,,,,,"Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200178,,,,,,,,,,,,,,,,2645,GCK,,,,,,,,,,,GCK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2575,"[""barbiturate dependence""]",,A drug dependence that involves the continued use of barbiturates despite problems related to use of the substance.,false,,,http://purl.obolibrary.org/obo/DOID_9974,,,,,,,,A drug dependence that involves the continued use of barbiturates despite problems related to use of the substance.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2575,,,,SNOMEDCT:231472009|ICD9CM:304.11|UMLS_CUI:C0154482,,,disease_ontology,,DOID:2575,,,,,,,,,,,,,,,,,,,barbiturate dependence,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9370,"[""exophthalmos""]",,An eye disease that is characterized by a bulging of the eye anteriorly out of the orbit.,false,,,http://purl.obolibrary.org/obo/DOID_5614,,,,,,,,An eye disease that is characterized by a bulging of the eye anteriorly out of the orbit.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9370,,,,NCI:C118763|SNOMEDCT_US_2016_03_01:18265008|SNOMEDCT_US_2016_03_01:155200004|UMLS_CUI:C0015300|NCI:C87114|SNOMEDCT_US_2016_03_01:267746003|ICD9CM:376.30|MESH:D005094|ICD10CM:H05.20,proptosis,,disease_ontology,,DOID:9370,,,,,,,,,,,,,,,,,,,exophthalmos,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400433,"[""KCNJ6 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400433,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ6 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003650,"[""optic ganglion""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000497,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003650,,,,,,,BrendaTissueOBO,,BTO:0003650,,,,,,,,,,,,,,,,,,,optic ganglion,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000223,"[""MET92 in ULK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000223,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET92 in ULK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9975,"[""cocaine dependence""]",,A drug dependence that is a psychological dependency on the regular use of cocaine.,false,,,http://purl.obolibrary.org/obo/DOID_9974,,,,,,,,A drug dependence that is a psychological dependency on the regular use of cocaine.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9975,,,,SNOMEDCT_US_2016_03_01:191834008|SNOMEDCT_US_2016_03_01:191830004|SNOMEDCT_US_2016_03_01:31956009|MESH:D019970|SNOMEDCT_US_2016_03_01:192254002|UMLS_CUI:C0600427|ICD9CM:304.20|NCI:C34492|SNOMEDCT_US_2016_03_01:191829009|SNOMEDCT_US_2016_03_01:286934009|ICD9CM:304.2|ICD10CM:F14.2,,,disease_ontology,,DOID:9975,,,,,,,,,,,,,,,,,,,cocaine dependence,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002817,"[""esophageal cancer cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0003640|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002817,,,,,,,BrendaTissueOBO,,BTO:0002817,,,,,,,,,,,,,,,,,,,esophageal cancer cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000261,"[""PHE301 in DYRK2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000261,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE301 in DYRK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200612,"[""NME6 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200612,,,,,,,,,,,,,,,,,,,,,,,,,,,,NME6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200488,"[""SRPK3 gene""]",,"This gene encodes a protein kinase similar to a protein kinase which is specific for the SR (serine/arginine-rich domain) family of splicing factors. A highly similar protein has been shown to play a role in muscle development in mice. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400226,,,,,,,,"This gene encodes a protein kinase similar to a protein kinase which is specific for the SR (serine/arginine-rich domain) family of splicing factors. A highly similar protein has been shown to play a role in muscle development in mice. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200488,,,,,,,,,,,,,,,,26576,SRPK3,MSSK1|STK23,,,,,,,,,,SRPK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100423,"[""Olfactory receptor 52I2""]",,"An olfactory receptor 52I2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH67] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 52I2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH67] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100423,,,,https://pharos.nih.gov/idg/targets/Q8NH67,,,,,,,,,,,,,OR52I2,,,Q8NH67,,,,,,,,Olfactory receptor 52I2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400151,"[""PEK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400151,,,,,,,,,,,,,,,,,,,,,,,,,,,,PEK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100312,"[""Olfactory receptor 10J1""]",,"An olfactory receptor 10J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30954] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30954] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100312,,,,https://pharos.nih.gov/idg/targets/P30954,,,,,,,,,,,,,OR10J1,,,P30954,,,,,,,,Olfactory receptor 10J1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5810,"[""adenosine deaminase deficiency""]",,"A severe combined immunodeficiency that is caused by a defective enzyme, adenosine deaminase (ADA), necessary for the breakdown of purines. Lack of ADA causes accumulation of dATP.",false,,,http://purl.obolibrary.org/obo/DOID_627,,,,,,,,"A severe combined immunodeficiency that is caused by a defective enzyme, adenosine deaminase (ADA), necessary for the breakdown of purines. Lack of ADA causes accumulation of dATP.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5810,,,,OMIM:102700|UMLS_CUI:C0268124|SNOMEDCT_US_2016_03_01:190738006|SNOMEDCT_US_2016_03_01:124523006|NCI:C3962|CSP:1560-6660|SNOMEDCT_US_2016_03_01:190999009|ICD10CM:D81.3|SNOMEDCT_US_2016_03_01:44940001,ADA ,,disease_ontology,,DOID:5810,,,,,,,,,,,,,,,,,,,adenosine deaminase deficiency,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001043,"[""adult""]",,Fully developed and mature: GROWN-UP.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000284,,,,,,,,Fully developed and mature: GROWN-UP.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001043,,,,,,,BrendaTissueOBO,adult stage,BTO:0001043,,,,,,,,,,,,,,,,,,,adult,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200241,"[""LPAR4 gene""]",,"A lysophosphatidic acid receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99677] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402007,,,,,,,,"A lysophosphatidic acid receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99677] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200241,,,,,,,,,,,,,,,,2846,LPAR4,GPR23|LPA4|P2RY9,,,,,,,,,,LPAR4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300582,"[""TRPC7 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300482,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300582,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPC7 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200053,"[""CAMKV gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400135,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200053,,,,,,,,,,,,,,,,79012,CAMKV,,,,,,,,,,,CAMKV gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100644,"[""Olfactory receptor 5r1""]",,"An olfactory receptor 5R1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH85] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5R1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH85] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100644,,,,https://pharos.nih.gov/idg/targets/Q8NH85,,,,,,,,,,,,,OR5R1,OR5R1P,,Q8NH85,,,,,,,,Olfactory receptor 5r1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400131,"[""PDHK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400108,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400131,,,,,,,,,,,,,,,,,,,,,,,,,,,,PDHK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400342,"[""Intracellular chloride channel (clic) family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400342,,,,,,,,,,,,,,,,,,,,,,,,,,,,Intracellular chloride channel (clic) family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400303,"[""PAKA subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400187,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400303,,,,,,,,,,,,,,,,,,,,,,,,,,,,PAKA subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100298,"[""Serine/threonine-protein kinase mak""]",,"serine/threonine-protein kinase mak (MAK)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase MAK that is encoded in the genome of human. [PRO:DNx, UniProtKB:P20794] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300162,,,,,,,,"serine/threonine-protein kinase mak (MAK)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase MAK that is encoded in the genome of human. [PRO:DNx, UniProtKB:P20794] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100298,,,,https://pharos.nih.gov/idg/targets/P20794,,,,,,,,,,,,,MAK,,,P20794,,,,,,,,Serine/threonine-protein kinase mak,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100071,"[""Cyclin-dependent-like kinase 5""]",,cyclin-dependent-like kinase 5 (CDK5)  with  no mutation  in a nonphosphorylated state|A cell division protein kinase 5 that is encoded in the genome of human. ,false,,,http://www.drugtargetontology.org/dto/DTO_03300261,,,,,,,,cyclin-dependent-like kinase 5 (CDK5)  with  no mutation  in a nonphosphorylated state|A cell division protein kinase 5 that is encoded in the genome of human. ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100071,,,,https://pharos.nih.gov/idg/targets/Q00535,,,,,,,,,,,,,CDK5,CDKN5,,Q00535,,,,,,,,Cyclin-dependent-like kinase 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400463,"[""Nav1.1/SCN1A subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400369,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400463,,,,,,,,,,,,,,,,,,,,,,,,,,,,Nav1.1/SCN1A subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000362,"[""urinary bladder cancer cell""]",,Cancer cell of the organ responsible for temporarily holding urine after it leaves the kidneys.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Cancer cell of the organ responsible for temporarily holding urine after it leaves the kidneys.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000362,,,,,,,BrendaTissueOBO,urinary bladder carcinoma cell|bladder cancer cell|bladder carcinoma cell|bladder tumour cell,BTO:0000362,,,,,,,,,,,,,,,,,,,urinary bladder cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200504,"[""STK38 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400181,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200504,,,,,,,,,,,,,,,,11329,STK38,NDR1,,,,,,,,,,STK38 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100295,"[""Mitogen-activated protein kinase kinase kinase kinase 3""]",,"A mitogen-activated protein kinase kinase kinase kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IVH8] |mitogen-activated protein kinase kinase kinase kinase 3 (M4K3)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300287,,,,,,,,"A mitogen-activated protein kinase kinase kinase kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IVH8] |mitogen-activated protein kinase kinase kinase kinase 3 (M4K3)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100295,,,,https://pharos.nih.gov/idg/targets/Q8IVH8,,,,,,,,,,,,,MAP4K3,RAB8IPL1,,Q8IVH8,,,,,,,,Mitogen-activated protein kinase kinase kinase kinase 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000926,"[""ophthalmic nerve""]",,"The one of the three major branches or divisions of the trigeminal nerve that supply sensory fibers to the lacrimal gland, eyelids, ciliary muscle, nose, forehead, and adjoining parts.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The one of the three major branches or divisions of the trigeminal nerve that supply sensory fibers to the lacrimal gland, eyelids, ciliary muscle, nose, forehead, and adjoining parts.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000926,,,,,,,BrendaTissueOBO,ophthalmic division,BTO:0000926,,,,,,,,,,,,,,,,,,,ophthalmic nerve,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100637,"[""Serine/threonine-protein kinase rio3""]",,"A serine/threonine-protein kinase RIO3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14730] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391036,,,,,,,,"A serine/threonine-protein kinase RIO3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14730] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100637,,,,https://pharos.nih.gov/idg/targets/O14730,,,,,,,,,,,,,RIOK3,SUDD,,O14730,,,,,,,,Serine/threonine-protein kinase rio3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200590,"[""OR4K1 gene""]",,"An olfactory receptor 4K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4K1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200590,,,,,,,,,,,,,,,,79544,OR4K1,,,,,,,,,,,OR4K1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000133,"[""MET153 in MRCKB""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000133,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET153 in MRCKB,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300469,"[""Nav1.4/SCN4A subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300369,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300469,,,,,,,,,,,,,,,,,,,,,,,,,,,,Nav1.4/SCN4A subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100156,"[""Inward rectifier potassium channel 18""]",,"An inward rectifier potassium channel 18 that is encoded in the genome of human. [PRO:DNx, UniProtKB:B7U540] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300423,,,,,,,,"An inward rectifier potassium channel 18 that is encoded in the genome of human. [PRO:DNx, UniProtKB:B7U540] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100156,,,,https://pharos.nih.gov/idg/targets/B7U540,,,,,,,,,,,,,KCNJ18,,,B7U540,,,,,,,,Inward rectifier potassium channel 18,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005739,"[""transfer cell""]",,"A type of plant cell specialized for the short-distance high-volume transport of materials. Transfer cells have numerous knobs and ridges on the inner surface of the primary cell wall. These greatly increase the surface area of the plasma membrane, which follows the contours of the protuberances. The expanded plasma membrane can accommodate a large number of transport proteins, which are responsible for transporting materials in or out of the cell. Transfer cells are found mainly in salt-secreting glands and in regions where photosynthate (sugar) is loaded or unloaded into sieve elements of phloem.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A type of plant cell specialized for the short-distance high-volume transport of materials. Transfer cells have numerous knobs and ridges on the inner surface of the primary cell wall. These greatly increase the surface area of the plasma membrane, which follows the contours of the protuberances. The expanded plasma membrane can accommodate a large number of transport proteins, which are responsible for transporting materials in or out of the cell. Transfer cells are found mainly in salt-secreting glands and in regions where photosynthate (sugar) is loaded or unloaded into sieve elements of phloem.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005739,Marion,2015-04-27T11:26:58Z,,,,,BrendaTissueOBO,,BTO:0005739,,,,,,,,,,,,,,,,,,,transfer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100083,"[""D(3) dopamine receptor""]",,"A D(3) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35462] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300037,,,,,,,,"A D(3) dopamine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35462] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100083,,,,https://pharos.nih.gov/idg/targets/P35462,,,,,,,,,,,,,DRD3,,,P35462,,,,,,,,D(3) dopamine receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2834,"[""acquired polycythemia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_8432,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2834,,,,SNOMEDCT_US_2016_03_01:44865000|NCI:C27178|UMLS_CUI:C1318533|ICD9CM:289.0|ICD10CM:D75.1|SNOMEDCT_US_2016_03_01:154835002|SNOMEDCT_US_2016_03_01:191374009,"secondary polycythemia|secondary polycythemia (disorder)|secondary polycythemia NOS (disorder)|secondary Polycythemia|Polycythemia, secondary",,disease_ontology,,DOID:2834,,,,,,,,,,,,,,,,,,,acquired polycythemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200012,"[""CHRNA7 gene""]",,"The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400496,,,,,,,,"The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200012,,,,,,,,,,,,,,,,1139|89832,CHRNA7,NACHRA7,,,,,,,,,,CHRNA7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200285,"[""RYR2 gene""]",,"This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400461,,,,,,,,"This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200285,,,,,,,,,,,,,,,,6262,RYR2,,,,,,,,,,,RYR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000495,"[""gametophyte""]",,The individual or generation of a plant exhibiting alternation of generations that bears sex organs.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000720,,,,,,,,The individual or generation of a plant exhibiting alternation of generations that bears sex organs.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000495,,,,,,,BrendaTissueOBO,,BTO:0000495,,,,,,,,,,,,,,,,,,,gametophyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10892,"[""hypospadias""]",,A physical disorder characterized by an abnormally placed urethral opening on the underside of the penis or on the perineum.,false,,,http://purl.obolibrary.org/obo/DOID_0080015,,,,,,,,A physical disorder characterized by an abnormally placed urethral opening on the underside of the penis or on the perineum.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10892,,,,MESH:D007021|OMIM:300633|OMIM:300758|OMIM:146450|ICD10CM:Q54.9|ORDO:440|SNOMEDCT_US_2016_03_01:416010008|OMIM:300856|UMLS_CUI:C0848558|ICD10CM:Q54|NCI:C40341,familial hypospadias,,disease_ontology,,DOID:10892,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,hypospadias,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000444,"[""TRKC kinase domain""]",,"Neurotrophic tyrosine kinase, receptor, type 3; gp145(trkC); NTRK3; TRKC",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Neurotrophic tyrosine kinase, receptor, type 3; gp145(trkC); NTRK3; TRKC",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000444,,,,,,,,,,,,,,,,,,,200445,,,,,,,,,TRKC kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000669,"[""embryonic cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000669,,,,,,,BrendaTissueOBO,,BTO:0000669,,,,,,,,,,,,,,,,,,,embryonic cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200251,"[""RPS6KA1 gene""]",,"This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400280,,,,,,,,"This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200251,,,,,,,,,,,,,,,,6195,RPS6KA1,MAPKAPK1A|RSK1,,,,,,,,,,RPS6KA1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400217,"[""RIO family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400108,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400217,,,,,,,,,,,,,,,,,,,,,,,,,,,,RIO family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300132,"[""SRC family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300132,,,,,,,,,,,,,,,,,,,,,,,,,,,,SRC family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100292,"[""Mitogen-activated protein kinase kinase kinase mlk4""]",,A mitogen-activated protein kinase kinase kinase that is encoded in the genome of human. ,false,,,http://www.drugtargetontology.org/dto/DTO_03300165,,,,,,,,A mitogen-activated protein kinase kinase kinase that is encoded in the genome of human. ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100292,,,,https://pharos.nih.gov/idg/targets/Q5TCX8,,,,,,,,,,,,,MLK4,KIAA1804,,Q5TCX8,,,,,,,,Mitogen-activated protein kinase kinase kinase mlk4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100364,"[""Olfactory receptor 2aj1""]",,"An olfactory receptor 2AJ1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2AJ1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGZ0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100364,,,,https://pharos.nih.gov/idg/targets/Q8NGZ0,,,,,,,,,,,,,OR2AJ1,OR2AJ1P,,Q8NGZ0,,,,,,,,Olfactory receptor 2aj1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9060,"[""pityriasis versicolor""]",,"A superficial mycosis that is a chronic, superficial fungal infection of the skin caused by Malassezia furfur, which is characterized by well-demarcated white, pink, fawn, or brownish lesions, often coalescing, and covered with thin furfuraceous scales.",false,,,http://purl.obolibrary.org/obo/DOID_0050133,,,,,,,,"A superficial mycosis that is a chronic, superficial fungal infection of the skin caused by Malassezia furfur, which is characterized by well-demarcated white, pink, fawn, or brownish lesions, often coalescing, and covered with thin furfuraceous scales.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9060,,,,NCI:C82981|MESH:D014010|SNOMEDCT_US_2016_03_01:154395007|NCI:C112833|ICD10CM:B36.0|ICD9CM:111.0|UMLS_CUI:C0040262|SNOMEDCT_US_2016_03_01:56454009,Pityriasis versicolor (disorder)|Infection by Pityrosporum furfur,,disease_ontology,,DOID:9060,,,,,,,,,,,,,,,,,,,pityriasis versicolor,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400550,"[""Kv6.2/KCNG2 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400447,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400550,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv6.2/KCNG2 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200360,"[""NEK6 gene""]",,"The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400197,,,,,,,,"The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200360,,,,,,,,,,,,,,,,10783,NEK6,,,,,,,,,,,NEK6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100435,"[""Olfactory receptor 52R1""]",,"An olfactory receptor 52R1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 52R1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100435,,,,https://pharos.nih.gov/idg/targets/Q8NGF1,,,,,,,,,,,,,OR52R1,,,Q8NGF1,,,,,,,,Olfactory receptor 52R1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001819,"[""stria vascularis""]",,"The upper part of the spiral ligament of the scala media that contains numerous small blood vessels; A layer of vascular tissue consisting of epithelial cells, mesothelial cells, and probably some neuroectoderm; it covers the outer wall of the cochlear duct and is thought to secrete the endolymph.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The upper part of the spiral ligament of the scala media that contains numerous small blood vessels; A layer of vascular tissue consisting of epithelial cells, mesothelial cells, and probably some neuroectoderm; it covers the outer wall of the cochlear duct and is thought to secrete the endolymph.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001819,,,,,,,BrendaTissueOBO,vascular stria of cochlear duct|stria vascularis ductus cochlearis,BTO:0001819,,,,,,,,,,,,,,,,,,,stria vascularis,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300228,"[""ULK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300228,,,,,,,,,,,,,,,,,,,,,,,,,,,,ULK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000206,"[""JNK1 kinase domain""]",,Mitogen-activated protein kinase 8; JNK; JNK1; JNK1A2; JNK21B1/2; MAPK8; PRKM8; SAPK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Mitogen-activated protein kinase 8; JNK; JNK1; JNK1A2; JNK21B1/2; MAPK8; PRKM8; SAPK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000206,,,,,,,,,,,,,,,,,,,200211,,,,,,,,,JNK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100464,"[""Ovarian cancer G-protein coupled receptor 1""]",,"A sphingosylphosphorylcholine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15743] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A sphingosylphosphorylcholine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15743] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100464,,,,https://pharos.nih.gov/idg/targets/Q15743,,,,,,,,,,,,,GPR68,OGR1,,Q15743,,,,,,,,Ovarian cancer G-protein coupled receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200324,"[""OR10V1 gene""]",,"An olfactory receptor 10V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10V1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGI7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200324,,,,,,,,,,,,,,,,390201,OR10V1,,,,,,,,,,,OR10V1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200096,"[""FFAR3 gene""]",,"A free fatty acid receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14843] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400040,,,,,,,,"A free fatty acid receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14843] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200096,,,,,,,,,,,,,,,,2865,FFAR3,GPR41,,,,,,,,,,FFAR3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000412,"[""epiphyseal growth plate""]",,The disk or plate of cartilage interposed between the epiphysis and the shaft of the bone during the period of growth; by its growth the bone increases in length.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000206,,,,,,,,The disk or plate of cartilage interposed between the epiphysis and the shaft of the bone during the period of growth; by its growth the bone increases in length.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000412,,,,,,,BrendaTissueOBO,epiphyseal cartilage|cartilago epiphysialis|physis|epiphyseal growth disk|growth plate|epiphyseal disk,BTO:0000412,,,,,,,,,,,,,,,,,,,epiphyseal growth plate,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000235,"[""LIMK1 kinase domain""]",,LIM domain kinase 1; LIMK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,LIM domain kinase 1; LIMK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000235,,,,,,,,,,,,,,,,,,,200225,,,,,,,,,LIMK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000098,"[""CSNK1A1L kinase domain""]",,"Casein kinase 1, alpha 1-like; CK1; CK1a2; CSNK1A1L; MGC33182",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Casein kinase 1, alpha 1-like; CK1; CK1a2; CSNK1A1L; MGC33182",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000098,,,,,,,,,,,,,,,,,,,200097,,,,,,,,,CSNK1A1L kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200312,"[""OR10J1 gene""]",,"An olfactory receptor 10J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30954] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30954] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200312,,,,,,,,,,,,,,,,26476,OR10J1,,,,,,,,,,,OR10J1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100183,"[""Inhibitor of nuclear factor kappa-b kinase subunit epsilon""]",,"inhibitor of nuclear factor kappa-b kinase subunit epsilon (IKKE)  with  no mutation  in a nonphosphorylated state|An inhibitor of nuclear factor kappa-B kinase subunit epsilon encoded in the genome of human. [PMID:10882136, PMID:17327220, PRO:CNA, Reactome:REACT_21591] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300164,,,,,,,,"inhibitor of nuclear factor kappa-b kinase subunit epsilon (IKKE)  with  no mutation  in a nonphosphorylated state|An inhibitor of nuclear factor kappa-B kinase subunit epsilon encoded in the genome of human. [PMID:10882136, PMID:17327220, PRO:CNA, Reactome:REACT_21591] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100183,,,,https://pharos.nih.gov/idg/targets/Q14164,,,,,,,,,,,,,IKBKE,IKKE|IKKI|KIAA0151,,Q14164,,,,,,,,Inhibitor of nuclear factor kappa-b kinase subunit epsilon,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200240,"[""LPAR3 gene""]",,"A lysophosphatidic acid receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UBY5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402007,,,,,,,,"A lysophosphatidic acid receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UBY5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200240,,,,,,,,,,,,,,,,23566,LPAR3,EDG7|LPA3,,,,,,,,,,LPAR3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050801,"[""androgenic alopecia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_987,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050801,lschriml,2013-11-21T12:48:07Z,,OMIM:612421|OMIM:300710|OMIM:109200,"alopecia androgenetica, male pattern baldness|androgenetic alopecia",,disease_ontology,,DOID:0050801,,,,,,,,,,,,,,,,,,,androgenic alopecia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000023,"[""ILE902 in TIE2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30009,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000023,,,,,,,,,,,,,,,,,,,,,,,,,,,,ILE902 in TIE2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200748,"[""PTGIR gene""]",,"A prostacyclin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43119] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A prostacyclin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43119] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200748,,,,,,,,,,,,,,,,5739,PTGIR,PRIPR,,,,,,,,,,PTGIR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200562,"[""OR3A2 gene""]",,"An olfactory receptor 3A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47893] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 3A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47893] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200562,,,,,,,,,,,,,,,,4995,OR3A2,OLFRA04,,,,,,,,,,OR3A2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300550,"[""Kv6.2/KCNG2 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300447,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300550,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv6.2/KCNG2 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100010,"[""E600 in BRAF(V600E)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100010,,,,,,,,,,,,,,,,,,,,,,,,,,,,E600 in BRAF(V600E),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100361,"[""Olfactory receptor 2ae1""]",,"An olfactory receptor 2AE1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHA4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2AE1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHA4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100361,,,,https://pharos.nih.gov/idg/targets/Q8NHA4,,,,,,,,,,,,,OR2AE1,OR2AE2,,Q8NHA4,,,,,,,,Olfactory receptor 2ae1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80320,"[""Orexin B""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16106|CAS:205599-76-4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80320,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80320,,,,,Orexin B,,CHEBI:80320,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004986,"[""SNU-5 cell""]",,Gastric carcinoma cell line; derived in 1987 by J. Park and associates from ascites of a patient with poorly differentiated carcinoma of the stomach.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000787,,,,,,,,Gastric carcinoma cell line; derived in 1987 by J. Park and associates from ascites of a patient with poorly differentiated carcinoma of the stomach.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004986,XPMUser,2011-02-26T04:43:45Z,,,,,BrendaTissueOBO,,BTO:0004986,,,,,,,,,,,,,,,,,,,SNU-5 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100318,"[""Two pore calcium channel protein 2""]",,"A two pore calcium channel protein 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8NHX9] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300481,,,,,,,,"A two pore calcium channel protein 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8NHX9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100318,,,,https://pharos.nih.gov/idg/targets/Q8NHX9,,,,,,,,,,,,,TPCN2,TPC2,,Q8NHX9,,,,,,,,Two pore calcium channel protein 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3165,"[""skin benign neoplasm""]",,,false,,,http://purl.obolibrary.org/obo/DOID_0060121,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3165,,,,NCI:C3372|UMLS_CUI:C0037286|SNOMEDCT_US_2016_03_01:126488004|MESH:D012878|SNOMEDCT_US_2016_03_01:363230005,neoplasm of skin by site|tumor of the skin|skin neoplasm|neoplasm of skin (disorder),,disease_ontology,,DOID:3165,,,,,,,,,,,,,,,,,,,skin benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200105,"[""DDR1 gene""]",,"Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400148,,,,,,,,"Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200105,,,,,,,,,,,,,,,,780,DDR1,CAK|EDDR1|NEP,,,,,,,,,,DDR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200281,"[""MAP3K15 gene""]",,"The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses. [provided by RefSeq, Jul 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400186,,,,,,,,"The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses. [provided by RefSeq, Jul 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200281,,,,,,,,,,,,,,,,389840,MAP3K15,ASK3,,,,,,,,,,MAP3K15 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100086,"[""Dual specificity protein kinase clk1""]",,"A dual specificity protein kinase CLK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49759] |dual specificity protein kinase clk1 (CLK1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300140,,,,,,,,"A dual specificity protein kinase CLK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49759] |dual specificity protein kinase clk1 (CLK1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100086,,,,https://pharos.nih.gov/idg/targets/P49759,,,,,,,,,,,,,CLK1,CLK,,P49759,,,,,,,,Dual specificity protein kinase clk1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200473,"[""RHO gene""]",,"A rhodopsin that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08100] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A rhodopsin that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08100] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200473,,,,,,,,,,,,,,,,6010,RHO,OPN2,,,,,,,,,,RHO gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100032,"[""Alpha-2c adrenergic receptor""]",,"An alpha-2C adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P18825] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300093,,,,,,,,"An alpha-2C adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P18825] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100032,,,,https://pharos.nih.gov/idg/targets/P18825,,,,,,,,,,,,,ADRA2C,ADRA2L2|ADRA2RL2,,P18825,,,,,,,,Alpha-2c adrenergic receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9149,"[""hard palate cancer""]",,,false,,,http://purl.obolibrary.org/obo/DOID_8618,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9149,,,,UMLS_CUI:C0153375|SNOMEDCT_US_2016_03_01:363387004|ICD10CM:C05.0|SNOMEDCT_US_2016_03_01:93822006|NCI:C3528|ICD9CM:145.2,malignant tumor of hard palate (disorder)|Hard Palate|malignant tumor of the Hard Palate|malignant tumour of hard palate|malignant neoplasm of hard palate,,disease_ontology,,DOID:9149,,,,,,,,,,,,,,,,,,,hard palate cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11383,"[""cryptorchidism""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0080015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11383,,,,MESH:D003456|SNOMEDCT_US_2016_03_01:156967003|UMLS_CUI:C0010417|SNOMEDCT_US_2016_03_01:367721002|SNOMEDCT_US_2016_03_01:37501009|SNOMEDCT_US_2016_03_01:204882004|SNOMEDCT_US_2016_03_01:268226005|ICD10CM:Q53.9|SNOMEDCT_US_2016_03_01:204879009|NCI:C12326|OMIM:219050|SNOMEDCT_US_2016_03_01:204878001|ICD9CM:752.51,Undescended testicle|undescended testicles|Cryptorchism|Undescended testis,,disease_ontology,,DOID:11383,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,cryptorchidism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11389,"[""subdural empyema""]",,,false,,,http://purl.obolibrary.org/obo/DOID_331,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11389,,,,UMLS_CUI:C0038539|SNOMEDCT_US_2016_03_01:37660004|MESH:D013354,Subdural abscess (disorder),,disease_ontology,,DOID:11389,,,,,,,,,,,,,,,,,,,subdural empyema,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000317,"[""THR277 in ACVRL1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000317,,,,,,,,,,,,,,,,,,,,,,,,,,,,THR277 in ACVRL1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200202,"[""AK3 gene""]",,"The protein encoded by this gene is a GTP:ATP phosphotransferase that is found in the mitochondrial matrix. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03491006,,,,,,,,"The protein encoded by this gene is a GTP:ATP phosphotransferase that is found in the mitochondrial matrix. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200202,,,,,,,,,,,,,,,,50808,AK3,AK3L1|AK6|AKL3L,,,,,,,,,,AK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300201,"[""PAN3 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300201,,,,,,,,,,,,,,,,,,,,,,,,,,,,PAN3 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002681,"[""renal vein""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000234,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002681,,,,,,,BrendaTissueOBO,,BTO:0002681,,,,,,,,,,,,,,,,,,,renal vein,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100303,"[""Serine/threonine-protein kinase mark2""]",,"A serine/threonine-protein kinase MARK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7KZI7] |serine/threonine-protein kinase mark2 (MARK2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300290,,,,,,,,"A serine/threonine-protein kinase MARK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7KZI7] |serine/threonine-protein kinase mark2 (MARK2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100303,,,,https://pharos.nih.gov/idg/targets/Q7KZI7,,,,,,,,,,,,,MARK2,EMK1,,Q7KZI7,,,,,,,,Serine/threonine-protein kinase mark2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1247,"[""blood coagulation disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_74,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1247,,,DOID:13997|DOID:9474,SNOMEDCT_US_2016_03_01:127073005|ICD9CM:286|SNOMEDCT_US_2016_03_01:64779008|UMLS_CUI:C0005779|MESH:D001778|SNOMEDCT_US_2016_03_01:191303002|NCI:C2902|SNOMEDCT_US_2016_03_01:267562007|SNOMEDCT_US_2016_03_01:362970003|ICD10CM:D68.9|SNOMEDCT_US_2016_03_01:154815003,postpartum coagulation defect|postpartum coagulation defect with delivery,,disease_ontology,,DOID:1247,,,,,,,,,,,,,,,,,,,blood coagulation disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100591,"[""Adenylate kinase 8""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100591,,,,,,,,,,,,,,,,,AK8,,,Q96MA6,,,,,,,,Adenylate kinase 8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200057,"[""CCR5 gene""]",,"A C-C chemokine receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51681] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400095,,,,,,,,"A C-C chemokine receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51681] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200057,,,,,,,,,,,,,,,,1234,CCR5,CMKBR5,,,,,,,,,,CCR5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002043,"[""ECV-304 cell""]",,"Human urinary bladder carcinoma (derivative of T-24); described as being spontaneously immortalized from the umbilical cord vein of a new-born Japanese boy in 1984; cells were described to have a high proliferative potential in the absence of any growth factors; however, DNA fingerprinting at DSMZ showed clearly that this cell line is in reality a derivative of human urinary bladder carcinoma cell line T-24.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001209,,,,,,,,"Human urinary bladder carcinoma (derivative of T-24); described as being spontaneously immortalized from the umbilical cord vein of a new-born Japanese boy in 1984; cells were described to have a high proliferative potential in the absence of any growth factors; however, DNA fingerprinting at DSMZ showed clearly that this cell line is in reality a derivative of human urinary bladder carcinoma cell line T-24.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002043,,,,,,,BrendaTissueOBO,ECV 304 cell|ECV304 cell,BTO:0002043,,,,,,,,,,,,,,,,,,,ECV-304 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200341,"[""OR13C3 gene""]",,"An olfactory receptor 13C3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 13C3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200341,,,,,,,,,,,,,,,,138803,OR13C3,,,,,,,,,,,OR13C3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491008,"[""DCK/DGK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400322,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491008,,,,,,,,,,,,,,,,,,,,,,,,,,,,DCK/DGK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004518,"[""uterine gland""]",,"Simple or branched, tubular gland extending into the lamina propria-submucosa, secreting mucus, lipids, glycogen, protein.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001979,,,,,,,,"Simple or branched, tubular gland extending into the lamina propria-submucosa, secreting mucus, lipids, glycogen, protein.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004518,mgr,2010-02-11T10:19:34Z,,,,,BrendaTissueOBO,,BTO:0004518,,,,,,,,,,,,,,,,,,,uterine gland,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002912,"[""neuroepithelioma cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0002913|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002912,,,,,,,BrendaTissueOBO,,BTO:0002912,,,,,,,,,,,,,,,,,,,neuroepithelioma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001520,"[""umbilical vein endothelial cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0001519|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001520,,,,,,,BrendaTissueOBO,,BTO:0001520,,,,,,,,,,,,,,,,,,,umbilical vein endothelial cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100033,"[""Bestrophin-4""]",,"A bestrophin-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFU0] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300331,,,,,,,,"A bestrophin-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFU0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100033,,,,https://pharos.nih.gov/idg/targets/Q8NFU0,,,,,,,,,,,,,BEST4,VMD2L2,,Q8NFU0,,,,,,,,Bestrophin-4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200325,"[""OR10W1 gene""]",,"An olfactory receptor 10W1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 10W1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200325,,,,,,,,,,,,,,,,81341,OR10W1,OR10W1P,,,,,,,,,,OR10W1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100398,"[""Olfactory receptor 51H1""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100398,,,,https://pharos.nih.gov/idg/targets/Q8NH63,,,,,,,,,,,,,OR51H1P,OR51H1,,Q8NH63,,,,,,,,Olfactory receptor 51H1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100393,"[""Phosphoenolpyruvate carboxykinase [gtp], mitochondrial""]",,"A phosphoenolpyruvate carboxykinase [GTP], mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16822] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391022,,,,,,,,"A phosphoenolpyruvate carboxykinase [GTP], mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16822] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100393,,,,https://pharos.nih.gov/idg/targets/Q16822,,,,,,,,,,,,,PCK2,PEPCK2,,Q16822,,,,,,,,"Phosphoenolpyruvate carboxykinase [gtp], mitochondrial",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200010,"[""ACVR1C gene""]",,"ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400246,,,,,,,,"ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200010,,,,,,,,,,,,,,,,130399,ACVR1C,ALK7,,,,,,,,,,ACVR1C gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200560,"[""KDR gene""]",,"Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400242,,,,,,,,"Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200560,,,,,,,,,,,,,,,,3791,KDR,FLK1|VEGFR2,,,,,,,,,,KDR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_2700,"[""anandamide""]","arachidonoyl ethanolamide|5,8,11,14-Eicosatetraenoylethanolamide|Arachidonic acid N-(hydroxyethyl)amide|
InChI=1S/C22H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(25)23-20-21-24/h6-7,9-10,12-13,15-16,24H,2-5,8,11,14,17-21H2,1H3,(H,23,25)/b7-6-,10-9-,13-12-,16-15-
|N-arachidonoyl-2-hydroxyethylamide|Arachidonylethanolamide|Anandamide(20:4, N-6)|AEA|
N-(2-Hydroxyethyl)-5,8,11,14-Eicosatetraenamide (all-Z)
|N-(5Z,8Z,11Z,14Z-Eicosatetraenoyl)-ethanolamine|LGEQQWMQCRIYKG-DOFZRALJSA-N|C22H37NO2|
(all-Z)-N-(2-hydroxyethyl)-5,8,11,14-eicosatetraenamide
|N-arachidonoylethanolamine|N-(2-Hydroxyethyl)anachidonamide|N-(5Z,8Z,11Z,14Z-eicosatetraenoyl) ethanolamine|N-(5Z,8Z,11Z,14Z-icosatetraenoyl)-ethanolamide|N-arachidonoyl ethanolamine|C(CCC)C/C=C\C/C=C\C/C=C\C/C=C\CCCC(NCCO)=O|
(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)-5,8,11,14-eicosatetraenamide
|Anandamide (20.4, N-6)","
An N-(polyunsaturated fatty acyl)ethanolamine resulting from the formal condensation of carboxy group of arachidonic acid with amino group of ethanolamine.
",false,,,http://purl.obolibrary.org/obo/CHEBI_18059,,,,,,,Wikipedia:Anandamide|CiteXplore:16957004|CiteXplore:18691603|KEGG COMPOUND:C11695|Reaxys:7079463|CiteXplore:19330032|ChemIDplus:94421-68-8|CiteXplore:8814296|HMDB:HMDB04080|CiteXplore:19817812|LIPID MAPS:LMFA08040001|CiteXplore:15047233|CiteXplore:15997233|Beilstein:7079463|CiteXplore:16118355|CiteXplore:15797258|MetaCyc:CPD-7598|KEGG COMPOUND:94421-68-8,"
An N-(polyunsaturated fatty acyl)ethanolamine resulting from the formal condensation of carboxy group of arachidonic acid with amino group of ethanolamine.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:88116,,"
(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide
|Anandamide",,chebi_ontology,"arachidonoyl ethanolamide|5,8,11,14-Eicosatetraenoylethanolamide|Arachidonic acid N-(hydroxyethyl)amide|
InChI=1S/C22H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(25)23-20-21-24/h6-7,9-10,12-13,15-16,24H,2-5,8,11,14,17-21H2,1H3,(H,23,25)/b7-6-,10-9-,13-12-,16-15-
|N-arachidonoyl-2-hydroxyethylamide|Arachidonylethanolamide|Anandamide(20:4, N-6)|AEA|
N-(2-Hydroxyethyl)-5,8,11,14-Eicosatetraenamide (all-Z)
|N-(5Z,8Z,11Z,14Z-Eicosatetraenoyl)-ethanolamine|LGEQQWMQCRIYKG-DOFZRALJSA-N|C22H37NO2|
(all-Z)-N-(2-hydroxyethyl)-5,8,11,14-eicosatetraenamide
|N-arachidonoylethanolamine|N-(2-Hydroxyethyl)anachidonamide|N-(5Z,8Z,11Z,14Z-eicosatetraenoyl) ethanolamine|N-(5Z,8Z,11Z,14Z-icosatetraenoyl)-ethanolamide|N-arachidonoyl ethanolamine|C(CCC)C/C=C\C/C=C\C/C=C\C/C=C\CCCC(NCCO)=O|
(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)-5,8,11,14-eicosatetraenamide
|Anandamide (20.4, N-6)",,,CHEBI:2700,,,,,,,,,,,,,,,,,,,,,,,CHEBI:2700,,,,,anandamide|Anandamide,,CHEBI:2700,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200467,"[""OPN5 gene""]",,"An opsin-5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q6U736] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"An opsin-5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q6U736] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200467,,,,,,,,,,,,,,,,221391,OPN5,GPR136|PGR12|TMEM13,,,,,,,,,,OPN5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1067,"[""open-angle glaucoma""]",,A glaucoma characterized by optic nerve damage resulting in progressive loss of visual field and increased pressure in the eye due to trabecular blockage.,false,,,http://purl.obolibrary.org/obo/DOID_1686,,,,,,,,A glaucoma characterized by optic nerve damage resulting in progressive loss of visual field and increased pressure in the eye due to trabecular blockage.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1067,,,,SNOMEDCT_US_2016_03_01:193543002|MESH:D005902|OMIM:608696|SNOMEDCT_US_2016_03_01:193538009|ICD10CM:H40.10|OMIM:606689|EFO:0004190|OMIM:609887|ICD10CM:H40.13|SNOMEDCT_US_2016_03_01:193539001|SNOMEDCT_US_2016_03_01:84494001|OMIM:608695|ICD10CM:H40.1|OMIM:601682|SNOMEDCT_US_2016_03_01:111513000|OMIM:609745|OMIM:137750|OMIM:611274|SNOMEDCT_US_2016_03_01:46168003|ICD9CM:365.10|OMIM:177700|ICD9CM:365.13|OMIM:610535|OMIM:613100|OMIM:611276|OMIM:602429|NCI:C34641|OMIM:603383|ICD9CM:365.1|UMLS_CUI:C0017612,glaucoma simplex|pigmentary glaucoma|open angle glaucoma|Wide-angle glaucoma,,disease_ontology,,DOID:1067,,,,,,,,,,,,,,,,,Xref MGI.,,open-angle glaucoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80310,"[""Neuropeptide gamma""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16096,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80310,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80310,,,,,Neuropeptide gamma,,CHEBI:80310,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11983,"[""Prader-Willi syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0080014,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11983,,,,NCI:C75463|MESH:D011218|UMLS_CUI:C0032897|ICD10CM:Q87.1|SNOMEDCT_US_2016_03_01:89392001|ICD9CM:759.81|SNOMEDCT_US_2016_03_01:205794007|OMIM:176270,Prader Willi syndrome,,disease_ontology,,DOID:11983,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Prader-Willi syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11984,"[""hypertrophic cardiomyopathy""]",,An intrinsic cardiomyopathy that has_material_basis_in autosomal dominant inheritance and that is characterized by abnormal  thickening (hypertrophy) of the heart without any obvious cause.,false,,,http://purl.obolibrary.org/obo/DOID_0060036,,,,,,,,An intrinsic cardiomyopathy that has_material_basis_in autosomal dominant inheritance and that is characterized by abnormal  thickening (hypertrophy) of the heart without any obvious cause.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11984,,,DOID:11986,MESH:D002312|ICD9CM:425.1|SNOMEDCT_US_2016_03_01:266301006|NCI:C34449|OMIM:PS192600|SNOMEDCT_US_2016_03_01:389999002|SNOMEDCT_US_2016_03_01:233873004|KEGG:05410|ICD9CM:425.11|SNOMEDCT_US_2016_03_01:389998005|ICD10CM:I42.1|SNOMEDCT_US_2016_03_01:15471000|SNOMEDCT_US_2016_03_01:83978005|MESH:D024741|UMLS_CUI:C0007194|SNOMEDCT_US_2016_03_01:45227007|UMLS_CUI:C0949658|ORDO:155|SNOMEDCT_US_2016_03_01:155351008|NCI:C84773,hypertrophic obstructive cardiomyopathy|familial hypertrophic cardiomyopathy,,disease_ontology,,DOID:11984,,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,hypertrophic cardiomyopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_885,"[""fascioliasis""]",,"A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Fasciola hepatica or Fasciola gigantica. During the acute phase, manifestations include abdominal pain, hepatomegaly, fever, vomiting, diarrhea, urticaria and eosinophilia. Occasionally, infection occurs in intestinal wall, lungs, subcutaneous tissue, and pharyngeal mucosa.",false,,,http://purl.obolibrary.org/obo/DOID_883,,,,,,,,"A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Fasciola hepatica or Fasciola gigantica. During the acute phase, manifestations include abdominal pain, hepatomegaly, fever, vomiting, diarrhea, urticaria and eosinophilia. Occasionally, infection occurs in intestinal wall, lungs, subcutaneous tissue, and pharyngeal mucosa.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:885,,,,ICD9CM:121.3|ICD10CM:B66.3|SNOMEDCT_US_2016_03_01:111922007|MESH:D005211|SNOMEDCT_US_2016_03_01:187125007|UMLS_CUI:C0015652,Infection by Fasciola (disorder)|Fasciola hepatica infection (disorder)|Liver flukes NOS (disorder)|Sheep liver fluke infection|Liver flukes NOS,,disease_ontology,,DOID:885,,,,,,,,,,,,,,,,,,,fascioliasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_883,"[""parasitic helminthiasis infectious disease""]",,"A parasitic infectious disease that occurs when part of the body is infested with parasitic worms such as cestodes, nematodes and trematodes.",false,,,http://purl.obolibrary.org/obo/DOID_1398,,,,,,,,"A parasitic infectious disease that occurs when part of the body is infested with parasitic worms such as cestodes, nematodes and trematodes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:883,,,DOID:10693|DOID:3563|DOID:932|DOID:458,SNOMEDCT_US_2016_03_01:187542005|ICD10CM:B65-B83|SNOMEDCT_US_2016_03_01:187518006|ICD9CM:120-129.99|SNOMEDCT_US_2016_03_01:27601005|NCI:C84751|SNOMEDCT_US_2016_03_01:154410004|MESH:D006373|ICD9CM:128.9|UMLS_CUI:C0018889|ICD10CM:B83.9|SNOMEDCT_US_2016_03_01:266219000|SNOMEDCT_US_2016_03_01:187189004,helminthosis|helminth infection|helminthiasis|worm infection,,disease_ontology,,DOID:883,,,,,,,,,,,,,,,,,,,parasitic helminthiasis infectious disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000428,"[""TAOK3 kinase domain""]",,Serine/threonine-protein kinase TAO3; TAO kinase 3; DKFZp666H245; DPK; FLJ31808; JIK; MAP3K18; TAO3,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase TAO3; TAO kinase 3; DKFZp666H245; DPK; FLJ31808; JIK; MAP3K18; TAO3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000428,,,,,,,,,,,,,,,,,,,200429,,,,,,,,,TAOK3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200279,"[""PKD2L2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400367,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200279,,,,,,,,,,,,,,,,27039,PKD2L2,,,,,,,,,,,PKD2L2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000277,"[""PHE767 in PRP4""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000277,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE767 in PRP4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200042,"[""CACNA1E gene""]",,"Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400385,,,,,,,,"Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200042,,,,,,,,,,,,,,,,777,CACNA1E,CACH6|CACNL1A6,,,,,,,,,,CACNA1E gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11830,"[""myopia""]",,A refractive error characterized by the inability to see farther objects clearly.,false,,,http://purl.obolibrary.org/obo/DOID_9835,,,,,,,,A refractive error characterized by the inability to see farther objects clearly.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11830,,,,ICD9CM:367.1|OMIM:612717|UMLS_CUI:C0027092|ICD10CM:H52.1|OMIM:615946|OMIM:615420|OMIM:613959|OMIM:300613|OMIM:610320|OMIM:160700|OMIM:612554|OMIM:608908|EFO:0003927|OMIM:614166|OMIM:608367|OMIM:609256|OMIM:609257|OMIM:609259|OMIM:608474|NCI:C102533|OMIM:255500|OMIM:310460|MESH:D009216|OMIM:613969|OMIM:614167|OMIM:603221|SNOMEDCT_US_2016_03_01:57190000|SNOMEDCT_US_2016_03_01:155133003|OMIM:609258|OMIM:609995|OMIM:615431|OMIM:609994,short-sightedness|near vision|near-sightedness,,disease_ontology,,DOID:11830,,,,,,,,,,,,,,,,,Xref MGI.,,myopia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005671,"[""KGN cell""]",,"A steroidogenic human ovarian granulosa-like tumor cell line, from a patient with invasive ovarian granulosa cell carcinoma.",false,,,http://purl.obolibrary.org/obo/BTO_0002285|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A steroidogenic human ovarian granulosa-like tumor cell line, from a patient with invasive ovarian granulosa cell carcinoma.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005671,Marion,2014-09-05T10:19:11Z,,,,,BrendaTissueOBO,,BTO:0005671,,,,,,,,,,,,,,,,,,,KGN cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000204,"[""MET80 in NEK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000204,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET80 in NEK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000020,"[""ABL1(T315I) kinase domain""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000020,,,,,,,,,,,,,,,,,,,,,,,,,,,,ABL1(T315I) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100786,"[""Taste receptor type 2 member 40""]",,"A taste receptor type 2 member 40 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59535] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300014,,,,,,,,"A taste receptor type 2 member 40 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59535] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100786,,,,https://pharos.nih.gov/idg/targets/P59535,,,,,,,,,,,,,TAS2R40,GPR60,,P59535,,,,,,,,Taste receptor type 2 member 40,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100290,"[""Mitogen-activated protein kinase kinase kinase 8""]",,A mitogen-activated protein kinase kinase kinase 8 that is encoded in the genome of human. ,false,,,http://www.drugtargetontology.org/dto/DTO_03300185,,,,,,,,A mitogen-activated protein kinase kinase kinase 8 that is encoded in the genome of human. ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100290,,,,https://pharos.nih.gov/idg/targets/P41279,,,,,,,,,,,,,MAP3K8,COT|ESTF,,P41279,,,,,,,,Mitogen-activated protein kinase kinase kinase 8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100095,"[""Free fatty acid receptor 2""]",,"A free fatty acid receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O15552] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300040,,,,,,,,"A free fatty acid receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O15552] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100095,,,,https://pharos.nih.gov/idg/targets/O15552,,,,,,,,,,,,,FFAR2,FFA2|GPCR43|GPR43,,O15552,,,,,,,,Free fatty acid receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000431,"[""VAL916 in VGFR2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000431,,,,,,,,,,,,,,,,,,,,,,,,,,,,VAL916 in VGFR2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3261,"[""Job's syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_2959,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3261,,,,OMIM:147060|MESH:D007589|UMLS_CUI:C1968689|UMLS_CUI:C2936739,Job syndrome|hyperimmunoglobulin E syndrome,,disease_ontology,,DOID:3261,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Job's syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000102,"[""blood clot""]",,"A semisolid gelatinous mass of coagulated blood that consists of red blood cells, white blood cells, and platelets entrapped in a fibrin network.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"A semisolid gelatinous mass of coagulated blood that consists of red blood cells, white blood cells, and platelets entrapped in a fibrin network.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000102,,,,,,,BrendaTissueOBO,thrombus,BTO:0000102,,,,,,,,,,,,,,,,,,,blood clot,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200151,"[""GPR148 gene""]",,"A G-protein coupled receptor 148 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDV2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 148 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDV2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200151,,,,,,,,,,,,,,,,344561,GPR148,BTR|PGR6,,,,,,,,,,GPR148 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3613,"[""Canavan disease""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_10579,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3613,,,,NCI:C84611|MESH:D017825|UMLS_CUI:C0206307|OMIM:271900|SNOMEDCT_US_2016_03_01:80544005,CANAVAN-VAN BOGAERT-BERTRAND DISEASE|Spongy degeneration of central nervous system,,disease_ontology,,DOID:3613,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Canavan disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200771,"[""SSTR2 gene""]",,"A somatostatin receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30874] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A somatostatin receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30874] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200771,,,,,,,,,,,,,,,,6752,SSTR2,,,,,,,,,,,SSTR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400503,"[""Delta/CHRND sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400503,,,,,,,,,,,,,,,,,,,,,,,,,,,,Delta/CHRND sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1389,"[""polyneuropathy""]",,"A peripheral system disease that is characterized by is damage affecting peripheral nerves (peripheral neuropathy) in roughly the same areas on both sides of the body, featuring weakness, numbness, pins-and-needles, and burning pain.",false,,,http://purl.obolibrary.org/obo/DOID_574,,,,,,,,"A peripheral system disease that is characterized by is damage affecting peripheral nerves (peripheral neuropathy) in roughly the same areas on both sides of the body, featuring weakness, numbness, pins-and-needles, and burning pain.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1389,,,,ICD10CM:A69.22|SNOMEDCT_US_2016_03_01:42345000|SNOMEDCT_US_2016_03_01:193166009|MESH:D011115|SNOMEDCT_US_2016_03_01:155080009|SNOMEDCT_US_2016_03_01:307326004|SNOMEDCT_US_2016_03_01:194530007|ICD10CM:G62.9|UMLS_CUI:C0152025|NCI:C26951|SNOMEDCT_US_2016_03_01:193204000|SNOMEDCT_US_2016_03_01:267706009,,,disease_ontology,,DOID:1389,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,polyneuropathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391012,"[""Type I phosphatidylinositol-4-phosphate 5-kinase family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300323,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391012,,,,,,,,,,,,,,,,,,,,,,,,,,,,Type I phosphatidylinositol-4-phosphate 5-kinase family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_76,"[""stomach disease""]",,A gastrointestinal system disease that is located_in the stomach.,false,,,http://purl.obolibrary.org/obo/DOID_77,,,,,,,,A gastrointestinal system disease that is located_in the stomach.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:76,,,,SNOMEDCT_US_2016_03_01:196598004|MESH:D013272|UMLS_CUI:C0038354|SNOMEDCT_US_2016_03_01:29384001|SNOMEDCT_US_2016_03_01:183927002|SNOMEDCT_US_2016_03_01:266497000|NCI:C26886|SNOMEDCT_US_2016_03_01:155671005,stomach disorder|Gastropathy,,disease_ontology,gastric disease,DOID:76,,,,,,,,,,,,,,,,,,,stomach disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_769,"[""neuroblastoma""]",,An autonomic nervous system neoplasm that derives_from immature nerve cells.,false,,,http://purl.obolibrary.org/obo/DOID_2621,,,,,,,,An autonomic nervous system neoplasm that derives_from immature nerve cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:769,,,,OMIM:613016|OMIM:256700|OMIM:613015|ORDO:635|OMIM:613013|SNOMEDCT_US_2016_03_01:432328008|OMIM:613014|SNOMEDCT_US_2016_03_01:269507008|UMLS_CUI:C0027819|MESH:D009447|SNOMEDCT_US_2016_03_01:189931003|EFO:0000621|SNOMEDCT_US_2016_03_01:87364003|NCI:C3270,neuroblastoma (Schwannian Stroma-Poor),,disease_ontology,,DOID:769,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,neuroblastoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_768,"[""retinoblastoma""]",,A retinal cell cancer and malignant neoplasm of retina and neuroblastoma and neuroendocrine tumors that derives_from the tissues of the retina.,false,,,http://purl.obolibrary.org/obo/DOID_771|http://purl.obolibrary.org/obo/DOID_769,,,,,,,,A retinal cell cancer and malignant neoplasm of retina and neuroblastoma and neuroendocrine tumors that derives_from the tissues of the retina.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:768,,,,OMIM:180200|SNOMEDCT_US_2016_03_01:154553002|SNOMEDCT_US_2016_03_01:189934006|SNOMEDCT_US_2016_03_01:189935007|NCI:C7541|NCI:C6956|SNOMEDCT_US_2016_03_01:134191003|UMLS_CUI:C0035335|MESH:D012175|SNOMEDCT_US_2016_03_01:269614001|SNOMEDCT_US_2016_03_01:370967009|SNOMEDCT_US_2016_03_01:19906005,RB|RB - Retinoblastoma|neuroblastoma of Retina,,disease_ontology,,DOID:768,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,retinoblastoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_767,"[""muscular atrophy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_423,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:767,,,,SNOMEDCT_US_2016_03_01:156721007|SNOMEDCT_US_2016_03_01:155014006|SNOMEDCT_US_2016_03_01:203036002|SNOMEDCT_US_2016_03_01:268104000|SNOMEDCT_US_2016_03_01:267693003|NCI:C94834|UMLS_CUI:C0026846|SNOMEDCT_US_2016_03_01:249827008|MESH:D009133|SNOMEDCT_US_2016_03_01:88092000,Muscle wasting|Wasting - muscle|Amyotrophia,,disease_ontology,,DOID:767,,,,,,,,,,,,,,,,,,,muscular atrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_272,"[""hepatic vascular disease""]",,A vascular disease that is located_in the liver.,false,,,http://purl.obolibrary.org/obo/DOID_178|http://purl.obolibrary.org/obo/DOID_409,,,,,,,,A vascular disease that is located_in the liver.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:272,,,,NCI:C35442|UMLS_CUI:C0400923|SNOMEDCT_US_2016_03_01:235878005,vascular disorder of liver (disorder),,disease_ontology,,DOID:272,,,,,,,,,,,,,,,,,,,hepatic vascular disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100520,"[""Dual specificity testis-specific protein kinase 1""]",,"dual specificity testis-specific protein kinase 1 (TESK1)  with  no mutation  in a nonphosphorylated state|A dual specificity testis-specific protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15569] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300319,,,,,,,,"dual specificity testis-specific protein kinase 1 (TESK1)  with  no mutation  in a nonphosphorylated state|A dual specificity testis-specific protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15569] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100520,,,,https://pharos.nih.gov/idg/targets/Q15569,,,,,,,,,,,,,TESK1,,,Q15569,,,,,,,,Dual specificity testis-specific protein kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001718,"[""embryoid body""]",,"Embryoid bodies are structures resembling embryos, occurring in several types of germ cell tumors.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000809,,,,,,,,"Embryoid bodies are structures resembling embryos, occurring in several types of germ cell tumors.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001718,,,,,,,BrendaTissueOBO,,BTO:0001718,,,,,,,,,,,,,,,,,,,embryoid body,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000347,"[""PIK3CA(H1047Y) kinase domain""]",,"Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA; PI3K-alpha",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000347,,,,,,,,,,,,,,,,,,,200329,,,,,,,,,PIK3CA(H1047Y) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000741,"[""lymphocytic leukemia cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000737,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000741,,,,,,,BrendaTissueOBO,,BTO:0000741,,,,,,,,,,,,,,,,,,,lymphocytic leukemia cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200076,"[""CLCN5 gene""]",,"This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_01400399,,,,,,,,"This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200076,,,,,,,,,,,,,,,,1184,CLCN5,CLCK2,,,,,,,,,,CLCN5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100029,"[""Acid-sensing ion channel 5""]",,"An acid-sensing ion channel 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NY37] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300380,,,,,,,,"An acid-sensing ion channel 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NY37] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100029,,,,https://pharos.nih.gov/idg/targets/Q9NY37,,,,,,,,,,,,,ASIC5,ACCN5|HINAC,,Q9NY37,,,,,,,,Acid-sensing ion channel 5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100522,"[""Inactive serine/threonine-protein kinase tex14""]",,"A testis-expressed protein 14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IWB6] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300233,,,,,,,,"A testis-expressed protein 14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IWB6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100522,,,,https://pharos.nih.gov/idg/targets/Q8IWB6,,,,,,,,,,,,,TEX14,SGK307,,Q8IWB6,,,,,,,,Inactive serine/threonine-protein kinase tex14,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400311,"[""RIO2 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400217,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400311,,,,,,,,,,,,,,,,,,,,,,,,,,,,RIO2 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100065,"[""Cyclin-dependent kinase 19""]",,"A cyclin-dependent kinase 19 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BWU1] |cyclin-dependent kinase 19 (CDK11)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300257,,,,,,,,"A cyclin-dependent kinase 19 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BWU1] |cyclin-dependent kinase 19 (CDK11)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100065,,,,https://pharos.nih.gov/idg/targets/Q9BWU1,,,,,,,,,,,,,CDK19,CDC2L6|CDK11|KIAA1028,,Q9BWU1,,,,,,,,Cyclin-dependent kinase 19,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300330,"[""Amiloride-sensitive sodium channel family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300330,,,,,,,,,,,,,,,,,,,,,,,,,,,,Amiloride-sensitive sodium channel family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9297,"[""lip disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_403,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9297,,,,SNOMEDCT_US_2016_03_01:196563002|UMLS_CUI:C0023760|MESH:D008047|ICD9CM:528.5|SNOMEDCT_US_2016_03_01:90678009|ICD10CM:K13.0|NCI:C26818,disease of lips,,disease_ontology,,DOID:9297,,,,,,,,,,,,,,,,,,,lip disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6658,"[""pulmonary large cell neuroendocrine carcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4556,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6658,,,DOID:5721,NCI:C6875|UMLS_CUI:C1334363|UMLS_CUI:C1265996|NCI:C5672|SNOMEDCT_US_2016_03_01:128628002,,,disease_ontology,,DOID:6658,,,,,,,,,,,,,,,,,,,pulmonary large cell neuroendocrine carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300339,"[""Epithelial chloride channel (e-clc) family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300339,,,,,,,,,,,,,,,,,,,,,,,,,,,,Epithelial chloride channel (e-clc) family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9460,"[""uterine corpus cancer""]",,A uterine cancer that is located_in the uterine corpus.,false,,,http://purl.obolibrary.org/obo/DOID_363,,,,,,,,A uterine cancer that is located_in the uterine corpus.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9460,,,,SNOMEDCT_US_2016_03_01:188194001|SNOMEDCT_US_2016_03_01:371972005|ICD10CM:C54|ICD9CM:182|SNOMEDCT_US_2016_03_01:363442002|UMLS_CUI:C0153574|SNOMEDCT_US_2016_03_01:188200009|SNOMEDCT_US_2016_03_01:93718007|ICD10CM:C54.9|SNOMEDCT_US_2016_03_01:269600001|SNOMEDCT_US_2016_03_01:154526001|NCI:C3556,corpus uteri cancer,,disease_ontology,,DOID:9460,,,,,,,,,,,,,,,,,,,uterine corpus cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5588,"[""lung papillary adenocarcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3112|http://purl.obolibrary.org/obo/DOID_3910,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5588,,,,UMLS_CUI:C1335325|NCI:C5650,Papillary adenocarcinoma of the lung,,disease_ontology,,DOID:5588,,,,,,,,,,,,,,,,,,,lung papillary adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200366,"[""OR2AP1 gene""]",,"An olfactory receptor 2AP1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2AP1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200366,,,,,,,,,,,,,,,,121129,OR2AP1,OR2AP1P,,,,,,,,,,OR2AP1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400014,"[""Taste 2 receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400014,,,,,,,,,,,,,,,,,,,,,,,,,,,,Taste 2 receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5154,"[""borna disease""]",,"A viral infectious disease that results_in infection, which affects dopaminergic neurotransmission located_in central nervous system, has_material_basis_in Borna disease virus, which is transmitted_by contact with infected oronasal secretions. The infection has_symptom mood disturbances, has_symptom behaviour disturbances, has_symptom cognitive disturbances, has_symptom neurologic disturbances, and has_symptom movement impairment.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in infection, which affects dopaminergic neurotransmission located_in central nervous system, has_material_basis_in Borna disease virus, which is transmitted_by contact with infected oronasal secretions. The infection has_symptom mood disturbances, has_symptom behaviour disturbances, has_symptom cognitive disturbances, has_symptom neurologic disturbances, and has_symptom movement impairment.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5154,,,,SNOMEDCT_US_2016_03_01:76851008|MESH:D001890|UMLS_CUI:C0006023,Enzootic encephalomyelitis,,disease_ontology,,DOID:5154,http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,borna disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100422,"[""Olfactory receptor 52i1""]",,"An olfactory receptor 52I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 52I1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGK6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100422,,,,https://pharos.nih.gov/idg/targets/Q8NGK6,,,,,,,,,,,,,OR52I1,,,Q8NGK6,,,,,,,,Olfactory receptor 52i1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200133,"[""GPR114 gene""]",,"A G-protein coupled receptor 114 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,"A G-protein coupled receptor 114 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200133,,,,,,,,,,,,,,,,221188,GPR114,PGR27,,,,,,,,,,GPR114 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5670,"[""comedo carcinoma""]",,A carcinoma that is in situ.,false,,,http://purl.obolibrary.org/obo/DOID_8791,,,,,,,,A carcinoma that is in situ.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5670,,,,UMLS_CUI:C0334370|SNOMEDCT_US_2016_03_01:36425007|SNOMEDCT_US_2016_03_01:189709000|NCI:C4188,Comedocarcinoma,,disease_ontology,,DOID:5670,,,,,,,,,,,,,,,,,,,comedo carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491026,"[""GHMP kinase family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400324,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491026,,,,,,,,,,,,,,,,,,,,,,,,,,,,GHMP kinase family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001244,"[""urinary tract""]",,"The organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001491,,,,,,,,"The organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001244,,,,,,,BrendaTissueOBO,,BTO:0001244,,,,,,,,,,,,,,,,,,,urinary tract,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000428,"[""VAL804 in RET(V804L)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000428,,,,,,,,,,,,,,,,,,,,,,,,,,,,VAL804 in RET(V804L),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000073,"[""LEU483 in RPS6KA4(Kin.Dom.2-C-terminal)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000073,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU483 in RPS6KA4(Kin.Dom.2-C-terminal),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200547,"[""OR2T3 gene""]",,"An olfactory receptor 2T3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH03] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2T3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH03] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200547,,,,,,,,,,,,,,,,343173,OR2T3,,,,,,,,,,,OR2T3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000311,"[""NEK11 kinase domain""]",,NIMA (never in mitosis gene a)-related kinase 11; FLJ23495; NEK11,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,NIMA (never in mitosis gene a)-related kinase 11; FLJ23495; NEK11,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000311,,,,,,,,,,,,,,,,,,,200287,,,,,,,,,NEK11 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400361,"[""MCU family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400361,,,,,,,,,,,,,,,,,,,,,,,,,,,,MCU family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000662,"[""nasopharynx""]",,The upper part of the throat behind the nose. An opening on each side of the nasopharynx leads into the ear.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The upper part of the throat behind the nose. An opening on each side of the nasopharynx leads into the ear.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000662,,,,,,,BrendaTissueOBO,Nasenrachenraum,BTO:0000662,,,,,,,,,,,,,,,,,,,nasopharynx,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400532,"[""Kv1.1/KCNA1 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400436,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400532,,,,,,,,,,,,,,,,,,,,,,,,,,,,Kv1.1/KCNA1 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050793,"[""short QT syndrome""]",,"A heart conduction disease that is characterized by heart arrhythmia defined as a short QT interval on an EKG (less than 300 ms) that does not significantly change with heart rate, tall and peaked T waves, and a structurally normal heart.",false,,,http://purl.obolibrary.org/obo/DOID_10273,,,,,,,,"A heart conduction disease that is characterized by heart arrhythmia defined as a short QT interval on an EKG (less than 300 ms) that does not significantly change with heart rate, tall and peaked T waves, and a structurally normal heart.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050793,lschriml,2013-11-12T12:59:42Z,,OMIM:609620|OMIM:609621|OMIM:609622,,,disease_ontology,,DOID:0050793,,,,,,,,,,,,,,,,,,,short QT syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050792,"[""multiple cutaneous and mucosal venous malformations""]",,An autosomal dominant disease that is characterized by multiple bluish cutaneous or mucosal venous lesions.,false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,An autosomal dominant disease that is characterized by multiple bluish cutaneous or mucosal venous lesions.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050792,lschriml,2013-11-12T12:38:33Z,,OMIM:600195,,,disease_ontology,,DOID:0050792,,,,,,,,,,,,,,,,,,,multiple cutaneous and mucosal venous malformations,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050794,"[""multiple synostoses syndrome""]",,A dysostosis that is characterized by premature joint ankylosis and has_material_basis_in autosomal dominant inhertitance.,false,,,http://purl.obolibrary.org/obo/DOID_1934,,,,,,,,A dysostosis that is characterized by premature joint ankylosis and has_material_basis_in autosomal dominant inhertitance.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050794,lschriml,2013-11-12T01:08:42Z,,OMIM:186500|OMIM:612961|OMIM:610017,,,disease_ontology,,DOID:0050794,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,,,multiple synostoses syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050791,"[""persistent Mullerian duct syndrome""]",,"A pseudohermaphroditism that is characterized by the persistence of Mullerian duct derivatives (i.e. uterus, cervix, fallopian tubes and upper two thirds of vagina) in a phenotypically and karyotypically male.",false,,,http://purl.obolibrary.org/obo/DOID_3765,,,,,,,,"A pseudohermaphroditism that is characterized by the persistence of Mullerian duct derivatives (i.e. uterus, cervix, fallopian tubes and upper two thirds of vagina) in a phenotypically and karyotypically male.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050791,lschriml,2013-11-12T12:26:49Z,,SNOMEDCT_US_2016_03_01:702358005|UMLS_CUI:C1849930|MESH:C536665|NCI:C120188|OMIM:261550,persistent Muellerian duct syndrome,,disease_ontology,,DOID:0050791,,,,,,,,,,,,,,,,,,,persistent Mullerian duct syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050795,"[""cone dystrophy""]",,"A retinal disease that is characterized by the loss of cone cells, the photoreceptors responsible for both central and color vision.",false,,,http://purl.obolibrary.org/obo/DOID_5679,,,,,,,,"A retinal disease that is characterized by the loss of cone cells, the photoreceptors responsible for both central and color vision.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050795,lschriml,2013-11-12T01:19:22Z,,OMIM:610024|OMIM:180020|OMIM:610478|OMIM:610356|OMIM:613093,retinal cone dystrophy,,disease_ontology,,DOID:0050795,,,,,,,,,,,,,,,,,,,cone dystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400064,"[""Motilin receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400064,,,,,,,,,,,,,,,,,,,,,,,,,,,,Motilin receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000526,"[""glioma cell""]",,A tumor cell originating in the neuroglia of the brain or spinal cord.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A tumor cell originating in the neuroglia of the brain or spinal cord.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000526,,,,,,,BrendaTissueOBO,neuroglioma cell|neurogliocytoma cell|neurospongioma cell,BTO:0000526,,,,,,,,,,,,,,,,,,,glioma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200110,"[""DGUOK gene""]",,"In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03491008,,,,,,,,"In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200110,,,,,,,,,,,,,,,,1716,DGUOK,DGK,,,,,,,,,,DGUOK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200062,"[""CCRL2 gene""]",,"A C-C chemokine receptor-like 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00421] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400095,,,,,,,,"A C-C chemokine receptor-like 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00421] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200062,,,,,,,,,,,,,,,,9034,CCRL2,CCR11|CCR6|CKRX|CRAM|HCR,,,,,,,,,,CCRL2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000138,"[""INSL5""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000138,,,,,,,,,,,,,,,,,,,,,,,,,,,,INSL5,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100329,"[""Olfactory receptor 11g2""]",,"An olfactory receptor 11G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 11G2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGC1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100329,,,,https://pharos.nih.gov/idg/targets/Q8NGC1,,,,,,,,,,,,,OR11G2,,,Q8NGC1,,,,,,,,Olfactory receptor 11g2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_22563,"[""Anion""]",Anionen|anions|aniones|.,"
A monoatomic or polyatomic species having one or more elementary charges of the electron.
",false,,,http://purl.obolibrary.org/obo/CHEBI_24870,,,,,,,,"
A monoatomic or polyatomic species having one or more elementary charges of the electron.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,anion|Anion,,chebi_ontology,Anionen|anions|aniones|.,,,CHEBI:22563,,,,,,,,,,,,,,,,,,,,,,,CHEBI:22563,,,,,anion|Anion,,CHEBI:22563,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000044,"[""AURKA kinase domain""]",,Aurora kinase A; AIK; AIRK1; ARK1; Aur2; AURA; AurA/Aur2; AURKA; AURORA2; Aurora-A; Ayk1; BTAK; IAK; IAK1; MGC34538; STK15; STK6; STK7,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Aurora kinase A; AIK; AIRK1; ARK1; Aur2; AURA; AurA/Aur2; AURKA; AURORA2; Aurora-A; Ayk1; BTAK; IAK; IAK1; MGC34538; STK15; STK6; STK7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000044,,,,,,,,,,,,,,,,,,,200044,,,,,,,,,AURKA kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02400095,"[""C-C chemokine receptor gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02400031,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02400095,,,,,,,,,,,,,,,,,,,,,,,,,,,,C-C chemokine receptor gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100002,"[""5-hydroxytryptamine receptor 3B""]",,"A 5-hydroxytryptamine receptor 3B that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95264] ",false,,,http://www.drugtargetontology.org/dto/DTO_01309332,,,,,,,,"A 5-hydroxytryptamine receptor 3B that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95264] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100002,,,,https://pharos.nih.gov/idg/targets/O95264,,,,,,,,,,,,,HTR3B,,,O95264,,,,,,,,5-hydroxytryptamine receptor 3B,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10426,"[""Klippel-Feil syndrome""]",,A physical disorder that has_material_basis_in abnormal segmentation of the vertebra during fetal development which results_in fusion located_in cervical vertebra.,false,,,http://purl.obolibrary.org/obo/DOID_0080015,,,,,,,,A physical disorder that has_material_basis_in abnormal segmentation of the vertebra during fetal development which results_in fusion located_in cervical vertebra.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10426,,,DOID:14747,ICD10CM:Q76.1|SNOMEDCT_US_2016_03_01:268349005|OMIM:118100|SNOMEDCT_US_2016_03_01:388981000|SNOMEDCT_US_2016_03_01:129581007|OMIM:214300|ORDO:2345|SNOMEDCT_US_2016_03_01:157003009|UMLS_CUI:C0022738|NCI:C98967|SNOMEDCT_US_2016_03_01:5601008|OMIM:613702|ICD9CM:756.16|MESH:D007714|SNOMEDCT_US_2016_03_01:205441002,"congenital synostosis of cervical vertebrae|Klippel-Feil deformity, deafness and facial asymmetry|congenital dystrophia brevicollis|autosomal dominant Klippel-Feil syndrome|Klippel-Feil and Turner syndrome",,disease_ontology,,DOID:10426,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,Klippel-Feil syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100471,"[""Serine/threonine-protein kinase sgk1""]",,"A serine/threonine-protein kinase Sgk1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00141] |serine/threonine-protein kinase sgk1 (SGK1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300224,,,,,,,,"A serine/threonine-protein kinase Sgk1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00141] |serine/threonine-protein kinase sgk1 (SGK1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100471,,,,https://pharos.nih.gov/idg/targets/O00141,,,,,,,,,,,,,SGK1,SGK,,O00141,,,,,,,,Serine/threonine-protein kinase sgk1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000429,"[""TBK1 kinase domain""]",,Serine/threonine-protein kinase TBK1; TANK-binding kinase 1; NF-kappa-B-activating kinase; FLJ11330; NAK; T2K; TBK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase TBK1; TANK-binding kinase 1; NF-kappa-B-activating kinase; FLJ11330; NAK; T2K; TBK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000429,,,,,,,,,,,,,,,,,,,200430,,,,,,,,,TBK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300424,"[""KCNJ13 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300424,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ13 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80274,"[""Parathyroid hormone-related peptide (1-36)""]",PTHrP (1-36),,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16052,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,PTHrP (1-36),,,CHEBI:80274,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80274,,,,,Parathyroid hormone-related peptide (1-36),,CHEBI:80274,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11695,"[""portal vein thrombosis""]",,A vein disease that is characterized by a blood clot that forms within the hepatic portal vein.,false,,,http://purl.obolibrary.org/obo/DOID_866|http://purl.obolibrary.org/obo/DOID_272,,,,,,,,A vein disease that is characterized by a blood clot that forms within the hepatic portal vein.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11695,,,,SNOMEDCT_US_2016_03_01:17920008|ICD10CM:I81|ICD9CM:452|SNOMEDCT_US_2016_03_01:155455003|NCI:C78565|UMLS_CUI:C0155773,,,disease_ontology,,DOID:11695,,,,,,,,,,,,,,,,,,,portal vein thrombosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001445,"[""tail bud""]",,The rapidly proliferating mass of cells at the caudal extremity of the embryo; remnant of the primitive node.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001639,,,,,,,,The rapidly proliferating mass of cells at the caudal extremity of the embryo; remnant of the primitive node.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001445,,,,,,,BrendaTissueOBO,tailbud|end bud,BTO:0001445,,,,,,,,,,,,,,,,,,,tail bud,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100198,"[""Tyrosine-protein kinase jak3""]",,"A tyrosine-protein kinase JAK3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P52333] |tyrosine-protein kinase jak3 (JAK3(Kin.Dom.2))  with  no mutation  in a nonphosphorylated state|tyrosine-protein kinase jak3 (JAK3(JH1domain-catalytic))  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300167,,,,,,,,"A tyrosine-protein kinase JAK3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P52333] |tyrosine-protein kinase jak3 (JAK3(Kin.Dom.2))  with  no mutation  in a nonphosphorylated state|tyrosine-protein kinase jak3 (JAK3(JH1domain-catalytic))  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100198,,,,https://pharos.nih.gov/idg/targets/P52333,,,,,,,,,,,,,JAK3,,,P52333,,,,,,,,Tyrosine-protein kinase jak3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200166,"[""GPR176 gene""]",,"A G-protein coupled receptor 176 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14439] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400053,,,,,,,,"A G-protein coupled receptor 176 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14439] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200166,,,,,,,,,,,,,,,,11245,GPR176,,,,,,,,,,,GPR176 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200381,"[""PI4K2A gene""]",,"Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001 [PubMed 11244087]).[supplied by OMIM, Mar 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03491005,,,,,,,,"Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001 [PubMed 11244087]).[supplied by OMIM, Mar 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200381,,,,,,,,,,,,,,,,55361,PI4K2A,,,,,,,,,,,PI4K2A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8619,"[""recurrent hypersomnia""]",,A sleep disorder that involves recurring bouts of excessive amounts of sleepiness.,false,,,http://purl.obolibrary.org/obo/DOID_535,,,,,,,,A sleep disorder that involves recurring bouts of excessive amounts of sleepiness.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8619,,,,MESH:D006970|UMLS_CUI:C0751226|SNOMEDCT_US_2016_03_01:426451004|ICD10CM:G47.13|ICD9CM:327.13,primary recurrent hypersomnia,,disease_ontology,,DOID:8619,,,,,,,,,,,,,,,,,,,recurrent hypersomnia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000393,"[""RPS6KA5(Kin.Dom.2-C-terminal) kinase domain""]",,"Ribosomal protein S6 kinase, 90kDa, polypeptide 5; MGC1911; MSK1; MSK1~b; MSPK1; RLPK; RPS6KA5",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Ribosomal protein S6 kinase, 90kDa, polypeptide 5; MGC1911; MSK1; MSK1~b; MSPK1; RLPK; RPS6KA5",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000393,,,,,,,,,,,,,,,,,,,"200395, 200396",,,,,,,,,RPS6KA5(Kin.Dom.2-C-terminal) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8580,"[""malignant histiocytosis""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3405,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8580,,,DOID:8579,SNOMEDCT_US_2016_03_01:277648007|MESH:D054747|SNOMEDCT_US_2016_03_01:118612006|SNOMEDCT_US_2016_03_01:188643009|SNOMEDCT_US_2016_03_01:128920006|SNOMEDCT_US_2016_03_01:134179007|SNOMEDCT_US_2016_03_01:188690006|SNOMEDCT_US_2016_03_01:66855003|NCI:C7202|SNOMEDCT_US_2016_03_01:8139000|UMLS_CUI:C0019623|ICD10CM:C96.A|ICD9CM:202.3,Stewart's granuloma|Histiocytic medullary reticulosis [obs]|malignant reticulosis|malignant midline reticulosis,,disease_ontology,,DOID:8580,,,,,,,,,,,,,,,,,,,malignant histiocytosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000103,"[""CSNK2A2 kinase domain""]",,"Casein kinase 2, alpha prime polypeptide; CK2A2; CSNK2A1; CSNK2A2; FLJ43934",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Casein kinase 2, alpha prime polypeptide; CK2A2; CSNK2A1; CSNK2A2; FLJ43934",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000103,,,,,,,,,,,,,,,,,,,200104,,,,,,,,,CSNK2A2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100349,"[""Myosin light chain kinase family member 4""]",,"myosin light chain kinase family member 4 (MYLK4)  with  no mutation  in a nonphosphorylated state|A myosin light chain kinase family member 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86YV6] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300196,,,,,,,,"myosin light chain kinase family member 4 (MYLK4)  with  no mutation  in a nonphosphorylated state|A myosin light chain kinase family member 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86YV6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100349,,,,https://pharos.nih.gov/idg/targets/Q86YV6,,,,,,,,,,,,,MYLK4,SGK085,,Q86YV6,,,,,,,,Myosin light chain kinase family member 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400587,"[""TRPM5 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400483,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400587,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPM5 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200549,"[""TYK2 gene""]",,"This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400167,,,,,,,,"This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200549,,,,,,,,,,,,,,,,7297,TYK2,,,,,,,,,,,TYK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400175,"[""PKC family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400175,,,,,,,,,,,,,,,,,,,,,,,,,,,,PKC family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100306,"[""Microtubule-associated serine/threonine-protein kinase 1""]",,"A microtubule-associated serine/threonine-protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y2H9] |microtubule-associated serine/threonine-protein kinase 1 (MAST1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300160,,,,,,,,"A microtubule-associated serine/threonine-protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y2H9] |microtubule-associated serine/threonine-protein kinase 1 (MAST1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100306,,,,https://pharos.nih.gov/idg/targets/Q9Y2H9,,,,,,,,,,,,,MAST1,KIAA0973|SAST,,Q9Y2H9,,,,,,,,Microtubule-associated serine/threonine-protein kinase 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4143,"[""orbital cancer""]",,"A bone cancer that is located_in the area behind the eye and derives_from the orbit or secondarily derives_from an adjacent source (eyelid, paranasal sinus, or intracranial compartment). It results_in the eye pushing forward causing a bulging of the eye called proptosis.",false,,,http://purl.obolibrary.org/obo/DOID_184,,,,,,,,"A bone cancer that is located_in the area behind the eye and derives_from the orbit or secondarily derives_from an adjacent source (eyelid, paranasal sinus, or intracranial compartment). It results_in the eye pushing forward causing a bulging of the eye called proptosis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4143,,,DOID:9984,MESH:D009918|SNOMEDCT_US_2016_03_01:188270008|SNOMEDCT_US_2016_03_01:363462005|NCI:C3562|SNOMEDCT_US_2016_03_01:127003006|UMLS_CUI:C0153626|UMLS_CUI:C0029185|ICD10CM:C69.6|SNOMEDCT_US_2016_03_01:93932000|NCI:C3290|ICD9CM:190.1,orbit cancer|orbital tumor|neoplasm of orbit proper (disorder)|malignant neoplasm of orbit,,disease_ontology,,DOID:4143,,,,,,,,,,,,,,,,,,,orbital cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200605,"[""OR4Q2 gene""]",,"An olfactory receptor 4Q2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C623] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4Q2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C623] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200605,,,,,,,,,,,,,,,,390432,OR4Q2,OR4Q2P,,,,,,,,,,OR4Q2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100117,"[""Galanin receptor type 3""]",,"A galanin receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O60755] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300046,,,,,,,,"A galanin receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O60755] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100117,,,,https://pharos.nih.gov/idg/targets/O60755,,,,,,,,,,,,,GALR3,GALNR3,,O60755,,,,,,,,Galanin receptor type 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200234,"[""KISS1R gene""]",,"A KiSS-1 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q969F8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400062,,,,,,,,"A KiSS-1 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q969F8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200234,,,,,,,,,,,,,,,,84634,KISS1R,AXOR12|GPR54,,,,,,,,,,KISS1R gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000040,"[""CCL16""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000040,,,,,,,,,,,,,,,,,,,,,,,,,,,,CCL16,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9252,"[""amino acid metabolic disorder""]",,An inherited metabolic disorders which impair the synthesis and degradation of amino acids.,false,,,http://purl.obolibrary.org/obo/DOID_655,,,,,,,,An inherited metabolic disorders which impair the synthesis and degradation of amino acids.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9252,,,,SNOMEDCT_US_2016_03_01:190740001|SNOMEDCT_US_2016_03_01:44779003|SNOMEDCT_US_2016_03_01:42930003|ICD9CM:270|SNOMEDCT_US_2016_03_01:154734005|SNOMEDCT_US_2016_03_01:267496003|ICD9CM:270.9|NCI:C97090|SNOMEDCT_US_2016_03_01:190680002|ICD10CM:E72.9|UMLS_CUI:C0002514|MESH:D000592,inborn errors of amino acid metabolism,,disease_ontology,,DOID:9252,,,,,,,,,,,,,,,,,,,amino acid metabolic disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100701,"[""Olfactory receptor 8j1""]",,"An olfactory receptor 8J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 8J1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100701,,,,https://pharos.nih.gov/idg/targets/Q8NGP2,,,,,,,,,,,,,OR8J1,,,Q8NGP2,,,,,,,,Olfactory receptor 8j1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000690,"[""brain cancer cell line""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0000255|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000690,,,,,,,BrendaTissueOBO,brain tumor cell line,BTO:0000690,,,,,,,,,,,,,,,,,,,brain cancer cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12010,"[""anterior ischemic optic neuropathy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1891,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12010,,,,ICD9CM:377.41|MESH:D018917|ICD10CM:H47.01|UMLS_CUI:C0155305|SNOMEDCT_US_2016_03_01:14357004,Ischemic optic neuropathy,,disease_ontology,,DOID:12010,,,,,,,,,,,,,,,,,,,anterior ischemic optic neuropathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060200,"[""amyotrophic lateral sclerosis type 9""]",,An amyotrophic lateral sclerosis that has material basis in mutation in the ANG gene on chromosome 14.,false,,,http://purl.obolibrary.org/obo/DOID_332,,,,,,,,An amyotrophic lateral sclerosis that has material basis in mutation in the ANG gene on chromosome 14.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060200,emitraka,2014-09-16T14:33:09Z,,OMIM:611895,ALS9|amyotrophic lateral sclerosis 9,,disease_ontology,,DOID:0060200,,,,,,,,,,,,,,,,,,,amyotrophic lateral sclerosis type 9,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000619,"[""ileal mucosa""]",,,false,,,http://purl.obolibrary.org/obo/BTO_0000642|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000619,,,,,,,BrendaTissueOBO,,BTO:0000619,,,,,,,,,,,,,,,,,,,ileal mucosa,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200681,"[""OR7D4 gene""]",,"An olfactory receptor 7D4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG98] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 7D4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG98] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200681,,,,,,,,,,,,,,,,125958,OR7D4,OR7D4P,,,,,,,,,,OR7D4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300384,"[""CACNA1D subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300333,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300384,,,,,,,,,,,,,,,,,,,,,,,,,,,,CACNA1D subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000269,"[""MET(M1250T) kinase domain""]",,Hepatocyte growth factor receptor; AUTS9; c-Met; HGFR; MET; RCCP2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Hepatocyte growth factor receptor; AUTS9; c-Met; HGFR; MET; RCCP2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000269,,,,,,,,,,,,,,,,,,,200260,,,,,,,,,MET(M1250T) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300190,"[""MET family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300190,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004684,"[""genital pore""]",,A small opening on the side of the head in some gastropods through which the penis is protruded.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A small opening on the side of the head in some gastropods through which the penis is protruded.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004684,mgr,2010-05-14T09:29:04Z,,,,,BrendaTissueOBO,genital orifice,BTO:0004684,,,,,,,,,,,,,,,,,,,genital pore,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000580,"[""blood cancer cell""]",,"The major forms of blood cancer are lymphoma, leukemia and multiple myeloma. They affect the way a body makes blood and provides immunity from other diseases.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The major forms of blood cancer are lymphoma, leukemia and multiple myeloma. They affect the way a body makes blood and provides immunity from other diseases.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000580,,,,,,,BrendaTissueOBO,,BTO:0000580,,,,,,,,,,,,,,,,,,,blood cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100002,"[""5-hydroxytryptamine receptor 1b""]",,"A 5-hydroxytryptamine receptor 1B that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28222] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302001,,,,,,,,"A 5-hydroxytryptamine receptor 1B that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28222] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100002,,,,https://pharos.nih.gov/idg/targets/P28222,,,,,,,,,,,,,HTR1B,HTR1DB,,P28222,,,,,,,,5-hydroxytryptamine receptor 1b,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8681,"[""paraneoplastic polyneuropathy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2537,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8681,,,,SNOMEDCT_US_2016_03_01:21361000119109|ICD9CM:357.3|MESH:D020364|UMLS_CUI:C0270932|SNOMEDCT_US_2016_03_01:77659000|NCI:C3981,,,disease_ontology,,DOID:8681,,,,,,,,,,,,,,,,,,,paraneoplastic polyneuropathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11782,"[""astigmatism""]",,"A refractive error characterized by the optics of the eye to focus a point object into a sharp focused image on the retina, has_symptom blurred vision.",false,,,http://purl.obolibrary.org/obo/DOID_9835,,,,,,,,"A refractive error characterized by the optics of the eye to focus a point object into a sharp focused image on the retina, has_symptom blurred vision.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11782,,,,SNOMEDCT_US_2016_03_01:193626006|ICD10CM:H52.20|SNOMEDCT_US_2016_03_01:193627002|SNOMEDCT_US_2016_03_01:155134009|UMLS_CUI:C0004106|OMIM:603047|CSP:1116-1831|ICD10CM:H52.2|ICD9CM:367.2|MESH:D001251|HP:0000483|SNOMEDCT_US_2016_03_01:82649003|EFO:0004222|ICD9CM:367.20,,,disease_ontology,,DOID:11782,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,astigmatism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200076,"[""CDKL1 gene""]",,"This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400138,,,,,,,,"This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200076,,,,,,,,,,,,,,,,8814,CDKL1,,,,,,,,,,,CDKL1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100405,"[""Olfactory receptor 51S1""]",,"An olfactory receptor 51S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 51S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGJ8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100405,,,,https://pharos.nih.gov/idg/targets/Q8NGJ8,,,,,,,,,,,,,OR51S1,,,Q8NGJ8,,,,,,,,Olfactory receptor 51S1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000414,"[""TYR262 in IRAK4""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_46858,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000414,,,,,,,,,,,,,,,,,,,,,,,,,,,,TYR262 in IRAK4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200058,"[""CDK12 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400136,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200058,,,,,,,,,,,,,,,,51755,CDK12,CRK7|CRKRS|KIAA0904,,,,,,,,,,CDK12 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100617,"[""Phosphoenolpyruvate carboxykinase, cytosolic [GTP]""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100617,,,,,,,,,,,,,,,,,PCK1,,,P35558,,,,,,,,"Phosphoenolpyruvate carboxykinase, cytosolic [GTP]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002425,"[""MSTO-211H cell""]",,Human mesothelioma cell line; established from the pleural effusion of a 62-year-old Caucasian man with mesothelioma (malignant biphasic) who did not have any prior therapy.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002424,,,,,,,,Human mesothelioma cell line; established from the pleural effusion of a 62-year-old Caucasian man with mesothelioma (malignant biphasic) who did not have any prior therapy.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002425,,,,,,,BrendaTissueOBO,211H cell|MSTO-211 H cell,BTO:0002425,,,,,,,,,,,,,,,,,,,MSTO-211H cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000251,"[""PHE238 in DYRK1A""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_29997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000251,,,,,,,,,,,,,,,,,,,,,,,,,,,,PHE238 in DYRK1A,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200051,"[""CCKAR gene""]",,"A cholecystokinin receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32238] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400030,,,,,,,,"A cholecystokinin receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32238] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200051,,,,,,,,,,,,,,,,886,CCKAR,CCKRA,,,,,,,,,,CCKAR gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100586,"[""Olfactory receptor 4f3/4f16/4f29""]",,An olfactory receptor 4F3/4F16/4F29 that is encoded in the genome of human. ,false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,An olfactory receptor 4F3/4F16/4F29 that is encoded in the genome of human. ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100586,,,,https://pharos.nih.gov/idg/targets/Q6IEY1,,,,,,,,,,,,,OR4F3,OR4F16|OR4F29,,Q6IEY1,,,,,,,,Olfactory receptor 4f3/4f16/4f29,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200277,"[""MAP3K11 gene""]",,"The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400284,,,,,,,,"The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200277,,,,,,,,,,,,,,,,4296,MAP3K11,MLK3|PTK1|SPRK,,,,,,,,,,MAP3K11 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001500,"[""tendril""]",,"A leaf, stipule, or stem modified into a slender spirally coiling sensitive organ serving to attach a climbing plant to its support.",false,,,http://purl.obolibrary.org/obo/BTO_0001300|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000713,,,,,,,,"A leaf, stipule, or stem modified into a slender spirally coiling sensitive organ serving to attach a climbing plant to its support.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001500,,,,,,,BrendaTissueOBO,,BTO:0001500,,,,,,,,,,,,,,,,,,,tendril,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002245,"[""foreskin fibroblast cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001619,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002245,,,,,,,BrendaTissueOBO,,BTO:0002245,,,,,,,,,,,,,,,,,,,foreskin fibroblast cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005577,"[""lung disease specific cell type""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005577,Marion,2014-03-02T21:08:31Z,,,,,BrendaTissueOBO,,BTO:0005577,,,,,,,,,,,,,,,,,,,lung disease specific cell type,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200129,"[""GPR110 gene""]",,"A G-protein coupled receptor 110 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5T601] ",false,,,http://www.drugtargetontology.org/dto/DTO_02402008,,,,,,,,"A G-protein coupled receptor 110 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5T601] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200129,,,,,,,,,,,,,,,,266977,GPR110,PGR19,,,,,,,,,,GPR110 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1932,"[""Angelman syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0080014,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1932,,,,SNOMEDCT_US_2016_03_01:76880004|UMLS_CUI:C0162635|MESH:D017204|OMIM:105830|ICD10CM:Q93.5|NCI:C75462,puppetlike syndrome|happy puppet syndrome,,disease_ontology,,DOID:1932,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Angelman syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10154,"[""small intestine cancer""]",,An intestinal cancer that is located_in the small intestine.,false,,,http://purl.obolibrary.org/obo/DOID_10155,,,,,,,,An intestinal cancer that is located_in the small intestine.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10154,,,,SNOMEDCT_US_2016_03_01:187755009|ICD10CM:C17.9|ICD10CM:C17|SNOMEDCT_US_2016_03_01:363509000|SNOMEDCT_US_2016_03_01:94048009|ICD9CM:152.9|SNOMEDCT_US_2016_03_01:154555009|UMLS_CUI:C0153425|NCI:C7523|SNOMEDCT_US_2016_03_01:269615000,,,disease_ontology,,DOID:10154,,,,,,,,,,,,,,,,,,,small intestine cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10155,"[""intestinal cancer""]",,A gastrointestinal system cancer that is located_in the intestine.,false,,,http://purl.obolibrary.org/obo/DOID_3119,,,,,,,,A gastrointestinal system cancer that is located_in the intestine.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10155,,,,MESH:D007414|SNOMEDCT_US_2016_03_01:363508008|SNOMEDCT_US_2016_03_01:190089002|ICD9CM:159.0|ICD10CM:C26.0|NCI:C4572|UMLS_CUI:C0346627|SNOMEDCT_US_2016_03_01:93838000|SNOMEDCT_US_2016_03_01:187819006,malignant neoplasm of intestine|malignant intestinal tumors,,disease_ontology,,DOID:10155,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,intestinal cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400393,"[""CLCNKA subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400341,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400393,,,,,,,,,,,,,,,,,,,,,,,,,,,,CLCNKA subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000217,"[""KIT(D816V) kinase domain""]",,V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; C-Kit; KIT; PBT; SCFR,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; C-Kit; KIT; PBT; SCFR,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000217,,,,,,,,,,,,,,,,,,,200217,,,,,,,,,KIT(D816V) kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200183,"[""GPR20 gene""]",,"A G-protein coupled receptor 20 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99678] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400053,,,,,,,,"A G-protein coupled receptor 20 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99678] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200183,,,,,,,,,,,,,,,,2843,GPR20,,,,,,,,,,,GPR20 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_63000005,"[""PIP5K""]",,"A Pfam protein family that contains a region from the common kinase core found in the type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K) family as described in [1]. The family consists of various type I, II and III PIP5K enzymes. PIP5K catalyses the formation of phosphoinositol-4,5-bisphosphate via the phosphorylation of phosphatidylinositol-4-phosphate a precursor in the phosphinositide signaling pathway.",false,,,http://www.drugtargetontology.org/dto/DTO_63000000,,,,,,,,"A Pfam protein family that contains a region from the common kinase core found in the type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K) family as described in [1]. The family consists of various type I, II and III PIP5K enzymes. PIP5K catalyses the formation of phosphoinositol-4,5-bisphosphate via the phosphorylation of phosphatidylinositol-4-phosphate a precursor in the phosphinositide signaling pathway.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_63000005,,,,,,,,,,,,,,,,,,,,,,,,,,,,PIP5K,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000852,"[""meristem""]",,A formative plant tissue usually made up of small cells capable of dividing indefinitely and giving rise to similar cells or to cells that differentiate to produce the definitive tissues and organs.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A formative plant tissue usually made up of small cells capable of dividing indefinitely and giving rise to similar cells or to cells that differentiate to produce the definitive tissues and organs.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000852,,,,,,,BrendaTissueOBO,,BTO:0000852,,,,,,,,,,,,,,,,,,,meristem,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200435,"[""OR52R1 gene""]",,"An olfactory receptor 52R1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 52R1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGF1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200435,,,,,,,,,,,,,,,,119695,OR52R1,,,,,,,,,,,OR52R1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100223,"[""Creatine kinase m-type""]",,"A creatine kinase M-type that is encoded in the genome of human. [PRO:DNx, UniProtKB:P06732] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391027,,,,,,,,"A creatine kinase M-type that is encoded in the genome of human. [PRO:DNx, UniProtKB:P06732] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100223,,,,https://pharos.nih.gov/idg/targets/P06732,,,,,,,,,,,,,CKM,CKMM,,P06732,,,,,,,,Creatine kinase m-type,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000403,"[""SBK1 kinase domain""]",,SH3-binding domain kinase 1; Sbk; SBK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,SH3-binding domain kinase 1; Sbk; SBK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000403,,,,,,,,,,,,,,,,,,,200407,,,,,,,,,SBK1 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00400004,"[""Tdark""]",,These are targets about which virtually nothing is known. They do not have known drug or small molecule activities that satisfy the activity thresholds detailed below AND satisfy two or more of the following criteria: (1) A PubMed text-mining score from Jensen Lab < 5 (2) <= 3 Gene RIFs (3) <= 50 Antibodies available according to http://antibodypedia.com|Tdark,false,,,http://www.drugtargetontology.org/dto/DTO_00400001,,,,,,,,These are targets about which virtually nothing is known. They do not have known drug or small molecule activities that satisfy the activity thresholds detailed below AND satisfy two or more of the following criteria: (1) A PubMed text-mining score from Jensen Lab < 5 (2) <= 3 Gene RIFs (3) <= 50 Antibodies available according to http://antibodypedia.com|Tdark,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00400004,,,,,,,,,,,,,,,,,,,,,,,,,,,,Tdark,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200622,"[""OR5D18 gene""]",,"An olfactory receptor 5D18 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5D18 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGL1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200622,,,,,,,,,,,,,,,,219438,OR5D18,,,,,,,,,,,OR5D18 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200103,"[""DCLK2 gene""]",,"This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400147,,,,,,,,"This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200103,,,,,,,,,,,,,,,,166614,DCLK2,DCAMKL2|DCDC3B|DCK2,,,,,,,,,,DCLK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100448,"[""Putative olfactory receptor 5AK3""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100448,,,,https://pharos.nih.gov/idg/targets/Q8NH89,,,,,,,,,,,,,OR5AK3P,OR5AK3,,Q8NH89,,,,,,,,Putative olfactory receptor 5AK3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200251,"[""MCOLN3 gene""]",,"This gene encodes one of members of the mucolipin cation channel proteins. Mutation studies of the highly similar protein in mice have shown that the protein is found in cochlea hair cells, and mutant mice show early-onset hearing loss and balance problems. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400576,,,,,,,,"This gene encodes one of members of the mucolipin cation channel proteins. Mutation studies of the highly similar protein in mice have shown that the protein is found in cochlea hair cells, and mutant mice show early-onset hearing loss and balance problems. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200251,,,,,,,,,,,,,,,,55283,MCOLN3,,,,,,,,,,,MCOLN3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000346,"[""digestive juice""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000346,,,,,,,BrendaTissueOBO,digestive fluid,BTO:0000346,,,,,,,,,,,,,,,,,,,digestive juice,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300272,"[""GSK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300159,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300272,,,,,,,,,,,,,,,,,,,,,,,,,,,,GSK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_786,"[""laryngeal disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_974,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:786,,,,MESH:D007818|ICD10CM:J38.7|SNOMEDCT_US_2016_03_01:60600009|ICD9CM:478.70|UMLS_CUI:C0023051|SNOMEDCT_US_2016_03_01:195863001|NCI:C26810|ICD10CM:S12.8,,,disease_ontology,,DOID:786,,,,,,,,,,,,,,,,,,,laryngeal disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_780,"[""placenta disease""]",,A uterine disease that is located_in the placenta.,false,,,http://purl.obolibrary.org/obo/DOID_345,,,,,,,,A uterine disease that is located_in the placenta.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:780,,,DOID:1815|DOID:5366|DOID:9219,UMLS_CUI:C1335423|MESH:D010922|NCI:C26857|SNOMEDCT_US_2016_03_01:156097009|SNOMEDCT_US_2016_03_01:156069003|SNOMEDCT_US_2016_03_01:23288008|SNOMEDCT_US_2016_03_01:199152008|NCI:C35169|ICD10CM:O43.9|SNOMEDCT_US_2016_03_01:267311008|ICD10CM:O43|SNOMEDCT_US_2016_03_01:156131006|SNOMEDCT_US_2016_03_01:156123001|ICD10CM:O43.90|NCI:C27619|UMLS_CUI:C0032045|SNOMEDCT_US_2016_03_01:172422001|NCI:C34941|UMLS_CUI:C0151864|SNOMEDCT_US_2016_03_01:198881004|SNOMEDCT_US_2016_03_01:173300003|ICD9CM:646.9|SNOMEDCT_US_2016_03_01:90821003|SNOMEDCT_US_2016_03_01:267293009|UMLS_CUI:C0032962|MESH:D011248|SNOMEDCT_US_2016_03_01:125586008|SNOMEDCT_US_2016_03_01:267314000,,,disease_ontology,,DOID:780,,,,,,,,,,,,,,,,,,,placenta disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_784,"[""chronic kidney disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1074,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:784,,,,NCI:C9438|EFO:0003884|SNOMEDCT_US_2016_03_01:90688005|ICD10CM:N18.9|MESH:D007676|UMLS_CUI:C0022661|SNOMEDCT_US_2016_03_01:46177005|ICD9CM:585.6|SNOMEDCT_US_2016_03_01:155856009|SNOMEDCT_US_2016_03_01:197755007|SNOMEDCT_US_2016_03_01:197654000|SNOMEDCT_US_2016_03_01:197655004,CKD|CRF|renal failure - chronic|chronic renal disease|chronic renal failure syndrome|chronic kidney failure,,disease_ontology,,DOID:784,,,,,,,,,,,,,,,,,,,chronic kidney disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100260,"[""Mas-related g-protein coupled receptor member g""]",,"A mas-related G-protein coupled receptor G that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86SM5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300063,,,,,,,,"A mas-related G-protein coupled receptor G that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q86SM5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100260,,,,https://pharos.nih.gov/idg/targets/Q86SM5,,,,,,,,,,,,,MRGPRG,GPR169|MRGG,,Q86SM5,,,,,,,,Mas-related g-protein coupled receptor member g,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200164,"[""GSK3A gene""]",,"This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400272,,,,,,,,"This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200164,,,,,,,,,,,,,,,,2931,GSK3A,,,,,,,,,,,GSK3A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300139,"[""RAD53 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300139,,,,,,,,,,,,,,,,,,,,,,,,,,,,RAD53 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200219,"[""CAMK2B gene""]",,"The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_03400172,,,,,,,,"The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200219,,,,,,,,,,,,,,,,816,CAMK2B,CAM2|CAMK2|CAMKB,,,,,,,,,,CAMK2B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391004,"[""AK2 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03391014,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391004,,,,,,,,,,,,,,,,,,,,,,,,,,,,AK2 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003960,"[""nasopharyngeal carcinoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000790,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003960,,,,,,,BrendaTissueOBO,,BTO:0003960,,,,,,,,,,,,,,,,,,,nasopharyngeal carcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_10923,"[""sickle cell anemia""]",,OMIM mapping confirmed by DO. [LS].,false,,,http://purl.obolibrary.org/obo/DOID_0050737,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:10923,,,DOID:12924|DOID:13024,ICD10CM:D57|NCI:C34383|SNOMEDCT_US_2016_03_01:191195005|SNOMEDCT_US_2016_03_01:127040003|UMLS_CUI:C0002895|NCI:C34676|ICD10CM:D57.2|ICD9CM:282.63|ICD10CM:D57.1|SNOMEDCT_US_2016_03_01:191194009|ICD9CM:282.6|SNOMEDCT_US_2016_03_01:80046004|ICD10CM:D57.20|SNOMEDCT_US_2016_03_01:276267006|OMIM:603903|SNOMEDCT_US_2016_03_01:154798006|ICD9CM:282.60|MESH:D006450|SNOMEDCT_US_2016_03_01:191199004|SNOMEDCT_US_2016_03_01:417357006|UMLS_CUI:C0019034|SNOMEDCT_US_2016_03_01:35434009|MESH:D000755,drepanocytosis|Hb-S/Hb-C disease|Sickle-cell/Hb-C disease without crisis|Hb SC disease|Hemoglobin S disease without crisis (disorder)|hemoglobin SC disease|Hb-SS disease without crisis,,disease_ontology,,DOID:10923,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [LS].,,sickle cell anemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000011,"[""3T3-L1 cell""]",,L1 is a continuous substrain of 3T3 Swiss albino developed through clonal isolation. Cells undergo a pre-adipose to adipose like conversion as they progress from a rapidly dividing to a confluent and contact inhibited state. A high serum content in the medium enhances fat accumulation.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,L1 is a continuous substrain of 3T3 Swiss albino developed through clonal isolation. Cells undergo a pre-adipose to adipose like conversion as they progress from a rapidly dividing to a confluent and contact inhibited state. A high serum content in the medium enhances fat accumulation.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000011,,,,,,,BrendaTissueOBO,NIH3T3-L1 cell,BTO:0000011,,,,,,,,,,,,,,,,,,,3T3-L1 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200476,"[""SIK2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400314,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200476,,,,,,,,,,,,,,,,23235,SIK2,KIAA0781|QIK|SNF1LK2,,,,,,,,,,SIK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000782,"[""T-lymphocyte""]",,"Any of several lymphocytes (as a helper T cell) that differentiate in the thymus, possess highly specific cell-surface antigen receptors, and include some that control the initiation or suppression of cell-mediated and humoral immunity (as by the regulation of T and B cell maturation and proliferation) and others that lyse antigen-bearing cells.",false,,,http://purl.obolibrary.org/obo/BTO_0000775|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"Any of several lymphocytes (as a helper T cell) that differentiate in the thymus, possess highly specific cell-surface antigen receptors, and include some that control the initiation or suppression of cell-mediated and humoral immunity (as by the regulation of T and B cell maturation and proliferation) and others that lyse antigen-bearing cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000782,,,,,,,BrendaTissueOBO,T-cell|T cell|T lymphocyte,BTO:0000782,,,,,,,,,,,,,,,,,,,T-lymphocyte,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4724,"[""brain edema""]",,,false,,,http://purl.obolibrary.org/obo/DOID_936,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4724,,,,SNOMEDCT_US_2016_03_01:85974009|SNOMEDCT_US_2016_03_01:2032001|UMLS_CUI:C1527311|MESH:D001929,intracranial swelling|wet brain,,disease_ontology,,DOID:4724,,,,,,,,,,,,,,,,,,,brain edema,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4843,"[""subependymal glioma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4844,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4843,,,,MESH:D018315|NCI:C3795|SNOMEDCT_US_2016_03_01:189910001|UMLS_CUI:C0206725|SNOMEDCT_US_2016_03_01:4553004,mixed subependymoma-ependymoma|Subependymal astrocytoma|WHO grade I Ependymal tumor|Subependymal astrocytoma NOS,,disease_ontology,,DOID:4843,,,,,,,,,,,,,,,,,,,subependymal glioma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100506,"[""Olfactory receptor 1S1""]",,"An olfactory receptor 1S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH92] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH92] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100506,,,,https://pharos.nih.gov/idg/targets/Q8NH92,,,,,,,,,,,,,OR1S1,,,Q8NH92,,,,,,,,Olfactory receptor 1S1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001785,"[""branchial arch""]",,"One of a series of bony or cartilaginous arches that develop in the walls of the mouth cavity and pharynx of a vertebrate embryo, consist typically of a curved segmented bar or rod on each side meeting the contralateral bar or rod at the ventral end, and correspond to the gill arches of fishes and amphibians.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"One of a series of bony or cartilaginous arches that develop in the walls of the mouth cavity and pharynx of a vertebrate embryo, consist typically of a curved segmented bar or rod on each side meeting the contralateral bar or rod at the ventral end, and correspond to the gill arches of fishes and amphibians.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001785,,,,,,,BrendaTissueOBO,visceral arch|pharyngeal arch,BTO:0001785,,,,,,,,,,,,,,,,,,,branchial arch,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000075,"[""CXCL11""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000075,,,,,,,,,,,,,,,,,,,,,,,,,,,,CXCL11,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100238,"[""Serine/threonine-protein kinase d1""]",,"serine/threonine-protein kinase d1 (KPCD1)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15139] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300176,,,,,,,,"serine/threonine-protein kinase d1 (KPCD1)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15139] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100238,,,,https://pharos.nih.gov/idg/targets/Q15139,,,,,,,,,,,,,PRKD1,PKD|PKD1|PRKCM,,Q15139,,,,,,,,Serine/threonine-protein kinase d1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9455,"[""lipid storage disease""]",,A lysosomal storage disease that involves the accumulation of harmful amounts of lipids (fats) in some of the body's cells and tissues.,false,,,http://purl.obolibrary.org/obo/DOID_3211,,,,,,,,A lysosomal storage disease that involves the accumulation of harmful amounts of lipids (fats) in some of the body's cells and tissues.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9455,,,DOID:10583,SNOMEDCT_US_2016_03_01:10741005|MESH:D008064|SNOMEDCT_US_2016_03_01:190797004|SNOMEDCT_US_2016_03_01:11455007|UMLS_CUI:C0023794|UMLS_CUI:C0029591|SNOMEDCT_US_2016_03_01:154744007|SNOMEDCT_US_2016_03_01:267437005|ICD9CM:272.8|SNOMEDCT_US_2016_03_01:190798009|ICD9CM:272.7|SNOMEDCT_US_2016_03_01:267438000|SNOMEDCT_US_2016_03_01:190792005|ICD10CM:E75.6|SNOMEDCT_US_2016_03_01:190805007,Lipoidosis|Lipoid storage diseas|inborn lipid storage disorder|lipoidosis,,disease_ontology,,DOID:9455,,,,,,,,,,,,,,,,,,,lipid storage disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200284,"[""RYR1 gene""]",,"This gene encodes a ryanodine receptor found in skeletal muscle. The encoded protein functions as a calcium release channel in the sarcoplasmic reticulum but also serves to connect the sarcoplasmic reticulum and transverse tubule. Mutations in this gene are associated with malignant hyperthermia susceptibility, central core disease, and minicore myopathy with external ophthalmoplegia. Alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400460,,,,,,,,"This gene encodes a ryanodine receptor found in skeletal muscle. The encoded protein functions as a calcium release channel in the sarcoplasmic reticulum but also serves to connect the sarcoplasmic reticulum and transverse tubule. Mutations in this gene are associated with malignant hyperthermia susceptibility, central core disease, and minicore myopathy with external ophthalmoplegia. Alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200284,,,,,,,,,,,,,,,,6261,RYR1,RYDR,,,,,,,,,,RYR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100470,"[""Uncharacterized serine/threonine-protein kinase sgk494""]",,An uncharacterized serine/threonine-protein kinase SgK494 that is encoded in the genome of human. ,false,,,http://www.drugtargetontology.org/dto/DTO_03300223,,,,,,,,An uncharacterized serine/threonine-protein kinase SgK494 that is encoded in the genome of human. ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100470,,,,https://pharos.nih.gov/idg/targets/Q96LW2,,,,,,,,,,,,,SGK494,,,Q96LW2,,,,,,,,Uncharacterized serine/threonine-protein kinase sgk494,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400349,"[""Phospholemman (plm) family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400349,,,,,,,,,,,,,,,,,,,,,,,,,,,,Phospholemman (plm) family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050572,"[""cone-rod dystrophy""]",,A retinal degeneration that characterized by progressive deterioration of the cone and rod photoreceptor cells.,false,,,http://purl.obolibrary.org/obo/DOID_8466,,,,,,,,A retinal degeneration that characterized by progressive deterioration of the cone and rod photoreceptor cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050572,,,,OMIM:602093|OMIM:600977|ORDO:1872|ICD10CM:H35.5|OMIM:300476|OMIM:613660|OMIM:600624|OMIM:615374|OMIM:300085|OMIM:614500|OMIM:615163|OMIM:612775|OMIM:603649|OMIM:615860|OMIM:601777|OMIM:608194|OMIM:610283|OMIM:615973|OMIM:604116|OMIM:304020|OMIM:610381|OMIM:605549|OMIM:120970|OMIM:607476|OMIM:612657,cone-rod dystrophy 5|cone-rod retinal dystrophy,,disease_ontology,,DOID:0050572,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,cone-rod dystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050578,"[""occult macular dystrophy""]",,A macular degeneration that is characterized by a central cone dysfunction leading to a loss of vision with a normal fundus and normal fluorescein angiography findings.,false,,,http://purl.obolibrary.org/obo/DOID_4448,,,,,,,,A macular degeneration that is characterized by a central cone dysfunction leading to a loss of vision with a normal fundus and normal fluorescein angiography findings.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050578,,,,OMIM:613587,,,disease_ontology,,DOID:0050578,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,occult macular dystrophy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050576,"[""Senior-Loken syndrome""]",,"An autosomal recessive genetic disease characterized by progressive wasting of the filtering unit of the kidney (nephronophthisis), with or without medullary cystic renal disease, and progressive eye disease.",false,,,http://purl.obolibrary.org/obo/DOID_0050737,,,,,,,,"An autosomal recessive genetic disease characterized by progressive wasting of the filtering unit of the kidney (nephronophthisis), with or without medullary cystic renal disease, and progressive eye disease.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050576,,,,OMIM:610189|ORDO:3156|OMIM:606995|OMIM:609254|OMIM:613615|OMIM:606996|ICD10CM:Q61.5|OMIM:266900,Loken Senior syndrome|renal-retinal syndrome,,disease_ontology,,DOID:0050576,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,Senior-Loken syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0050577,"[""Sensenbrenner syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050737,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0050577,,,,OMIM:218330|OMIM:613610,Levin syndrome|cranioectodermal dysplasia,,disease_ontology,,DOID:0050577,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Sensenbrenner syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300186,"[""STE11 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300113,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300186,,,,,,,,,,,,,,,,,,,,,,,,,,,,STE11 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001168,"[""rennet""]",,"1: The inner lining of the fourth stomach of calves and other young ruminants. 2: A dried extract made from the stomach lining of a ruminant, used in cheesemaking to curdle milk.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000024,,,,,,,,"1: The inner lining of the fourth stomach of calves and other young ruminants. 2: A dried extract made from the stomach lining of a ruminant, used in cheesemaking to curdle milk.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001168,,,,,,,BrendaTissueOBO,,BTO:0001168,,,,,,,,,,,,,,,,,,,rennet,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300194,"[""STE7 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300113,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300194,,,,,,,,,,,,,,,,,,,,,,,,,,,,STE7 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000514,"[""germ""]",,A small mass of living substance capable of developing into an organism or one of its parts.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000174|http://purl.obolibrary.org/obo/BTO_0000720,,,,,,,,A small mass of living substance capable of developing into an organism or one of its parts.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000514,,,,,,,BrendaTissueOBO,,BTO:0000514,,,,,,,,,,,,,,,,,,,germ,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100009,"[""D559 in KIT(V559D)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100009,,,,,,,,,,,,,,,,,,,,,,,,,,,,D559 in KIT(V559D),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001543,"[""metanephron""]",,"The primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord; Either member of the final and most caudal pair of the three successive pairs of vertebrate renal organs that functions as a permanent adult kidney in reptiles, birds, and mammals but is not present at all in lower forms.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord; Either member of the final and most caudal pair of the three successive pairs of vertebrate renal organs that functions as a permanent adult kidney in reptiles, birds, and mammals but is not present at all in lower forms.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001543,,,,,,,BrendaTissueOBO,definitive kidney|hind kidney|definite kidney|metanephros,BTO:0001543,,,,,,,,,,,,,,,,,,,metanephron,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100289,"[""Sodium channel protein type 1 subunit alpha""]",,"A sodium channel protein type 1 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35498] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300463,,,,,,,,"A sodium channel protein type 1 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35498] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100289,,,,https://pharos.nih.gov/idg/targets/P35498,,,,,,,,,,,,,SCN1A,NAC1|SCN1,,P35498,,,,,,,,Sodium channel protein type 1 subunit alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400159,"[""GSK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400111,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400159,,,,,,,,,,,,,,,,,,,,,,,,,,,,GSK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200570,"[""WNK4 gene""]",,"This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_03400244,,,,,,,,"This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200570,,,,,,,,,,,,,,,,65266,WNK4,PRKWNK4,,,,,,,,,,WNK4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004152,"[""UACC-62 cell""]",,Human melanoma cell line.,false,,,http://purl.obolibrary.org/obo/BTO_0000849|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Human melanoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004152,,,,,,,BrendaTissueOBO,UACC 62 cell|UACC62 cell,BTO:0004152,,,,,,,,,,,,,,,,,,,UACC-62 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12326,"[""chronic pulmonary heart disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_8515,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12326,,,,ICD9CM:416.8|SNOMEDCT_US_2016_03_01:194887007|UMLS_CUI:C0155673|SNOMEDCT_US_2016_03_01:194889005,,,disease_ontology,,DOID:12326,,,,,,,,,,,,,,,,,,,chronic pulmonary heart disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200102,"[""DCLK1 gene""]",,"This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400147,,,,,,,,"This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200102,,,,,,,,,,,,,,,,9201,DCLK1,DCAMKL1|DCDC3A|KIAA0369,,,,,,,,,,DCLK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1701,"[""steroid inherited metabolic disorder""]",,A lipid metabolism disorder that involves defects in steroid metabolism.,false,,,http://purl.obolibrary.org/obo/DOID_3146,,,,,,,,A lipid metabolism disorder that involves defects in steroid metabolism.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1701,,,,MESH:D043202|UMLS_CUI:C1257809,,,disease_ontology,,DOID:1701,,,,,,,,,,,,,,,,,,,steroid inherited metabolic disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100006,"[""5-hydroxytryptamine receptor 2A""]",,"A 5-hydroxytryptamine receptor 2A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28223] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302002,,,,,,,,"A 5-hydroxytryptamine receptor 2A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28223] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100006,,,,https://pharos.nih.gov/idg/targets/P28223,,,,,,,,,,,,,HTR2A,HTR2,,P28223,,,,,,,,5-hydroxytryptamine receptor 2A,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200653,"[""OR6B3 gene""]",,"An olfactory receptor 6B3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGW1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6B3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGW1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200653,,,,,,,,,,,,,,,,150681,OR6B3,OR6B3P,,,,,,,,,,OR6B3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200081,"[""CLIC3 gene""]",,"Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400342,,,,,,,,"Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200081,,,,,,,,,,,,,,,,9022,CLIC3,,,,,,,,,,,CLIC3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000013,"[""ABL1(H396P)-nonphosphorylated kinase domain""]",,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",false,,,http://www.drugtargetontology.org/dto/DTO_61000012,,,,,,,,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000013,,,,,,,,,,,,,,,,,,,"200011, 200012",,,,,,,,,ABL1(H396P)-nonphosphorylated kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_0900052,"[""[Leu31,Pro34]PYY (human)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_0900052,,,,,,,,,,,,,,,,,,,,,,,,,,,,"[Leu31,Pro34]PYY (human)",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2583,"[""agammaglobulinemia""]",,A B cell deficiency that is caused by a reduction in all types of gamma globulins.,false,,,http://purl.obolibrary.org/obo/DOID_2115,,,,,,,,A B cell deficiency that is caused by a reduction in all types of gamma globulins.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2583,,,DOID:618,OMIM:615214|SNOMEDCT_US_2016_03_01:119249001|UMLS_CUI:C0001768|ICD10CM:D80.1|ICD9CM:279.00|OMIM:613502|NCI:C26931|SNOMEDCT_US_2016_03_01:190977001|OMIM:613506|SNOMEDCT_US_2016_03_01:267512002|UMLS_CUI:C0086438|SNOMEDCT_US_2016_03_01:119250001|OMIM:612692|OMIM:613500|OMIM:601495|SNOMEDCT_US_2016_03_01:81282009|MESH:D000361|SNOMEDCT_US_2016_03_01:190978006|OMIM:613501,hypogammaglobulinemia|IGHM|mu heavy chain deficiency,,disease_ontology,,DOID:2583,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,agammaglobulinemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200170,"[""KCNAB2 gene""]",,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400356,,,,,,,,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200170,,,,,,,,,,,,,,,,8514,KCNAB2,KCNA2B|KCNK2,,,,,,,,,,KCNAB2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80161,"[""Galanin""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG COMPOUND:C15901,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80161,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80161,,,,,Galanin,,CHEBI:80161,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000320,"[""NLK kinase domain""]",,Serine/threonine-protein kinase NLK; Nemo-like kinase; DKFZp761G1211; FLJ21033,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase NLK; Nemo-like kinase; DKFZp761G1211; FLJ21033,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000320,,,,,,,,,,,,,,,,,,,200296,,,,,,,,,NLK kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4307,"[""polyradiculopathy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4308,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4307,,,,MESH:D011128|UMLS_CUI:C0032586|SNOMEDCT_US_2016_03_01:75572007|NCI:C34934,Polyradiculopathy (disorder),,disease_ontology,,DOID:4307,,,,,,,,,,,,,,,,,,,polyradiculopathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000653,"[""iris""]",,"The circular pigmented membrane behind the cornea, perforated by the pupil; the most anterior portion of the vascular tunic of the eye, it is made up of a flat bar of circular muscular fibers surrounding the pupil, a thin layer of smooth muscle fibers by which the pupil is dilated, thus regulating the amount of light entering the eye, and posteriorly two layers of pigmented epithelial cells.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The circular pigmented membrane behind the cornea, perforated by the pupil; the most anterior portion of the vascular tunic of the eye, it is made up of a flat bar of circular muscular fibers surrounding the pupil, a thin layer of smooth muscle fibers by which the pupil is dilated, thus regulating the amount of light entering the eye, and posteriorly two layers of pigmented epithelial cells.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000653,,,,,,,BrendaTissueOBO,,BTO:0000653,,,,,,,,,,,,,,,,,,,iris,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300376,"[""Acid-sensing ion channel 1 (ASIC1) subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300330,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300376,,,,,,,,,,,,,,,,,,,,,,,,,,,,Acid-sensing ion channel 1 (ASIC1) subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100416,"[""Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma""]",,phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1C)  with  no mutation  in a nonphosphorylated state|A phosphatidylinositol 4-phosphate 5-kinase type-1 gamma that is encoded in the genome of human. [Reactome:REACT_20457] ,false,,,http://www.drugtargetontology.org/dto/DTO_03391012,,,,,,,,phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1C)  with  no mutation  in a nonphosphorylated state|A phosphatidylinositol 4-phosphate 5-kinase type-1 gamma that is encoded in the genome of human. [Reactome:REACT_20457] ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100416,,,,https://pharos.nih.gov/idg/targets/O60331,,,,,,,,,,,,,PIP5K1C,KIAA0589,,O60331,,,,,,,,Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100202,"[""Potassium voltage-gated channel subfamily g member 2""]",,"A voltage-gated potassium channel KCNG2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UJ96] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300550,,,,,,,,"A voltage-gated potassium channel KCNG2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UJ96] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100202,,,,https://pharos.nih.gov/idg/targets/Q9UJ96,,,,,,,,,,,,,KCNG2,KCNF2,,Q9UJ96,,,,,,,,Potassium voltage-gated channel subfamily g member 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001501,"[""hair""]",,1: A slender threadlike outgrowth of the epidermis of an animal; especially: one of the usually pigmented filaments that form the characteristic coat of a mammal. 2: The hairy covering of an animal or a body part; especially: the coating of hairs on a human head.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,1: A slender threadlike outgrowth of the epidermis of an animal; especially: one of the usually pigmented filaments that form the characteristic coat of a mammal. 2: The hairy covering of an animal or a body part; especially: the coating of hairs on a human head.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001501,,,,,,,BrendaTissueOBO,,BTO:0001501,,,,,,,,,,,,,,,,,,,hair,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100239,"[""Serine/threonine-protein kinase d2""]",,"serine/threonine-protein kinase d2 (KPCD2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BZL6] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300176,,,,,,,,"serine/threonine-protein kinase d2 (KPCD2)  with  no mutation  in a nonphosphorylated state|A serine/threonine-protein kinase D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BZL6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100239,,,,https://pharos.nih.gov/idg/targets/Q9BZL6,,,,,,,,,,,,,PRKD2,PKD2,,Q9BZL6,,,,,,,,Serine/threonine-protein kinase d2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/UBERON_0000955,"[""brain""]",the brain|encephalon|suprasegmental levels of nervous system|suprasegmental structures|synganglion,"The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP].",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/UBERON_0001062,,,,,,,http://linkedlifedata.com/resource/umls/id/C0006104|http://www.snomedbrowser.com/Codes/Details/258335003|http://en.wikipedia.org/wiki/Brain|http://linkedlifedata.com/resource/umls/id/C1269537|GAID:571|ABA:Brain|galen:Brain|BAMS:Br|MA:0000168|XAO:0000010|NeuroNames:21|EHDAA:6485|UMLS:C0006104|NIF_GrossAnatomy:birnlex_796|CALOHA:TS-0095|ZFA:0000008|FMA:50801|OpenCyc:Mx4rvVjT65wpEbGdrcN5Y29ycA|FBbt:00005095|AAO:0010478|EHDAA:2641|EHDAA2:0000183|MAT:0000098|MESH:A08.186.211|MIAA:0000098|EMAPA:16894|BAMS:Brain|TAO:0000008|BTO:0000142|ncithesaurus:Brain|UMLS:C1269537|VHOG:0000157|BILA:0000135|EFO:0000302|EV:0100164,"The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP].",,,,,,,,,,"Part of the central nervous system situated within the cranium and composed of both nerve cell bodies and nerve fibers.[AAO]|Cavitated compound organ which is comprised of gray and white matter and surrounds the cerebral ventricular system.[TAO]|The part of the central nervous system contained within the cranium, comprising the forebrain, midbrain, hindbrain, and metencephalon. It is derived from the anterior part of the embryonic neural tube (or the encephalon). Does not include retina. (CUMBO)",,,,,,,,,,,,,,,,,,,,,,,,,,,,uberon,the brain|encephalon|suprasegmental levels of nervous system|suprasegmental structures|synganglion,," (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2).[well established][VHOG]",,,,,,,,,,,,,,,,,,,,,,,,UBERON:0000955,,,include synganglion?,,brain,,UBERON:0000955,,http://purl.obolibrary.org/obo/uberon.owl,http://purl.obolibrary.org/obo/uberon/core#efo_slim|http://purl.obolibrary.org/obo/uberon/core#cumbo|http://purl.obolibrary.org/obo/uberon/core#vertebrate_core|http://purl.obolibrary.org/obo/uberon/core#major_organ|http://purl.obolibrary.org/obo/uberon/core#uberon_slim,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200278,"[""MAP3K12 gene""]",,"This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400165,,,,,,,,"This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200278,,,,,,,,,,,,,,,,7786,MAP3K12,ZPK,,,,,,,,,,MAP3K12 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200219,"[""KCNK7 gene""]",,"This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; however, it may require other non-pore-forming proteins for activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400359,,,,,,,,"This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; however, it may require other non-pore-forming proteins for activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200219,,,,,,,,,,,,,,,,10089,KCNK7,,,,,,,,,,,KCNK7 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13868,"[""hypoactive sexual desire disorder""]",,,false,,,http://purl.obolibrary.org/obo/DOID_10132,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13868,,,,SNOMEDCT_US_2016_03_01:270903007|NCI:C94337|MESH:D020018|SNOMEDCT_US_2016_03_01:78889008|SNOMEDCT_US_2016_03_01:112096004|UMLS_CUI:C0020594|ICD10CM:F52.0|ICD9CM:302.71|SNOMEDCT_US_2016_03_01:192464008,Lack or loss of sexual desire,,disease_ontology,,DOID:13868,,,,,,,,,,,,,,,,,,,hypoactive sexual desire disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100536,"[""Tribbles homolog 2""]",,"A tribbles homolog 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92519] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300237,,,,,,,,"A tribbles homolog 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92519] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100536,,,,https://pharos.nih.gov/idg/targets/Q92519,,,,,,,,,,,,,TRIB2,TRB2,,Q92519,,,,,,,,Tribbles homolog 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200445,"[""RAF1 gene""]",,"This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400126,,,,,,,,"This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200445,,,,,,,,,,,,,,,,5894,RAF1,RAF,,,,,,,,,,RAF1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000057,"[""Alpha-ketoglutaric acid""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_33575,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000057,,,,,,,,,,,,,,,,,,,,,,,,,,,,Alpha-ketoglutaric acid,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100078,"[""Cyclin-dependent kinase-like 3""]",,"cyclin-dependent kinase-like 3 (CDKL3)  with  no mutation  in a nonphosphorylated state|A cyclin-dependent kinase-like 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IVW4] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300138,,,,,,,,"cyclin-dependent kinase-like 3 (CDKL3)  with  no mutation  in a nonphosphorylated state|A cyclin-dependent kinase-like 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IVW4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100078,,,,https://pharos.nih.gov/idg/targets/Q8IVW4,,,,,,,,,,,,,CDKL3,NKIAMRE,,Q8IVW4,,,,,,,,Cyclin-dependent kinase-like 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200129,"[""GLRA4 gene""]",,"This gene encodes a protein which has a neurotransmitter-gated ion-channel ligand binding domain. The encoded protein is very similar to a mouse protein which is a subunit of the retinal glycine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400528,,,,,,,,"This gene encodes a protein which has a neurotransmitter-gated ion-channel ligand binding domain. The encoded protein is very similar to a mouse protein which is a subunit of the retinal glycine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200129,,,,,,,,,,,,,,,,441509,GLRA4,,,,,,,,,,,GLRA4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9590,"[""lower urinary tract calculus""]",,A urinary system disease that is located_in the lower urinary tract and is characterized by the formation of a stone.,false,,,http://purl.obolibrary.org/obo/DOID_18,,,,,,,,A urinary system disease that is located_in the lower urinary tract and is characterized by the formation of a stone.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9590,,,,SNOMEDCT_US_2016_03_01:197832004|ICD9CM:594|SNOMEDCT_US_2016_03_01:155881007|SNOMEDCT_US_2016_03_01:155878002|UMLS_CUI:C0156264|ICD10CM:N21.9|ICD9CM:594.9|SNOMEDCT_US_2016_03_01:79509009|SNOMEDCT_US_2016_03_01:197828005|ICD10CM:N21,,,disease_ontology,,DOID:9590,,,,,,,,,,,,,,,,,,,lower urinary tract calculus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_121,"[""vaginal disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_229,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:121,,,,NCI:C26910|SNOMEDCT_US_2016_03_01:156015000|UMLS_CUI:C0042251|SNOMEDCT_US_2016_03_01:25658005|SNOMEDCT_US_2016_03_01:286989007|SNOMEDCT_US_2016_03_01:266665005|SNOMEDCT_US_2016_03_01:156018003|MESH:D014623,,,disease_ontology,,DOID:121,,,,,,,,,,,,,,,,,,,vaginal disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_127,"[""leiomyoma""]",,A cell type benign neoplasm that is a benign tumor of smooth muscle cells.,false,,,http://purl.obolibrary.org/obo/DOID_0060084,,,,,,,,A cell type benign neoplasm that is a benign tumor of smooth muscle cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:127,,,,MESH:D007889|SNOMEDCT_US_2016_03_01:189788005|NCI:C3157|SNOMEDCT_US_2016_03_01:189787000|UMLS_CUI:C0023267|SNOMEDCT_US_2016_03_01:702978006|SNOMEDCT_US_2016_03_01:189793008,leiomyomatous neoplasm (morphologic abnormality)|leiomyomatous tumor,,disease_ontology,,DOID:127,,,,,,,,,,,,,,,,,,,leiomyoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_120,"[""female reproductive organ cancer""]",,"A reproductive organ cancer that is manifested in the female genitals. This includes organs such as the ovaries, fallopian tubes, uterus, cervix, vagina and vulva.",false,,,http://purl.obolibrary.org/obo/DOID_193,,,,,,,,"A reproductive organ cancer that is manifested in the female genitals. This includes organs such as the ovaries, fallopian tubes, uterus, cervix, vagina and vulva.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:120,,,DOID:1244|DOID:1281,UMLS_CUI:C0699889|SNOMEDCT_US_2016_03_01:188207007|NCI:C4913|ICD10CM:C57|MESH:D005833|NCI:C3053|UMLS_CUI:C0153585|ICD9CM:184|SNOMEDCT_US_2016_03_01:126907002|UMLS_CUI:C0017416,malignant neoplasm of female genital organ|female reproductive cancer|malignant Gynecologic tumor,,disease_ontology,,DOID:120,,,,,,,,,,,,,,,,,,,female reproductive organ cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100633,"[""Olfactory receptor 5k4""]",,"An olfactory receptor 5K4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NMS3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 5K4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A6NMS3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100633,,,,https://pharos.nih.gov/idg/targets/A6NMS3,,,,,,,,,,,,,OR5K4,,,A6NMS3,,,,,,,,Olfactory receptor 5k4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000155,"[""FAK2 kinase domain""]",,Protein-tyrosine kinase 2-beta; CADTK; CAKB; FADK2; FAK2; PKB; PTK; PTK2B; PYK2; RAFTK,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Protein-tyrosine kinase 2-beta; CADTK; CAKB; FADK2; FAK2; PKB; PTK; PTK2B; PYK2; RAFTK,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000155,,,,,,,,,,,,,,,,,,,200367,,,,,,,,,FAK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_81664,"[""LL-37""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C18313,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:81664,,,,,,,,,,,,,,,,,,,,,,,CHEBI:81664,,,,,LL-37,,CHEBI:81664,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200783,"[""TAS2R31 gene""]",,"A taste receptor type 2 member 44 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59538] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400014,,,,,,,,"A taste receptor type 2 member 44 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59538] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200783,,,,,,,,,,,,,,,,259290,TAS2R31,TAS2R44,,,,,,,,,,TAS2R31 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1123,"[""spondyloarthropathy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_381,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1123,,,,SNOMEDCT_US_2016_03_01:372109003|SNOMEDCT_US_2016_03_01:357182002|MESH:D025242|UMLS_CUI:C0949691|OMIM:106300|SNOMEDCT_US_2016_03_01:8847002|SNOMEDCT_US_2016_03_01:359173000,spondylarthrosis|spondarthropathy,,disease_ontology,,DOID:1123,,,,,,,,,,,,,,,,,,,spondyloarthropathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01390005,"[""sodium channel""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01390005,,,,,,,,,,,,,,,,,,,,,,,,,,,,sodium channel,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300263,"[""CDK9 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300136,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300263,,,,,,,,,,,,,,,,,,,,,,,,,,,,CDK9 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300459,"[""NR1/GRIN1 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300459,,,,,,,,,,,,,,,,,,,,,,,,,,,,NR1/GRIN1 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_13476,"[""supraglottis cancer""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2596,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:13476,,,,SNOMEDCT_US_2016_03_01:269558005|NCI:C3545|ICD10CM:C32.1|ICD9CM:161.1|SNOMEDCT_US_2016_03_01:154482003|SNOMEDCT_US_2016_03_01:94080006|SNOMEDCT_US_2016_03_01:187842004|UMLS_CUI:C0153484,Ca larynx - supraglottis|malignant Supraglottic tumor|malignant neoplasm of supraglottis|malignant neoplasm of extrinsic larynx|malignant tumor of supraglottis (disorder)|supraglottis|Ca larynx - supraglottis (disorder),,disease_ontology,,DOID:13476,,,,,,,,,,,,,,,,,,,supraglottis cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3577,"[""Sertoli cell tumor""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4757,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3577,,,,UMLS_CUI:C0036769|SNOMEDCT_US_2016_03_01:128857001|MESH:D012707|SNOMEDCT_US_2016_03_01:189738002|SNOMEDCT_US_2016_03_01:89089007|NCI:C39976,tubular androblastoma NOS (morphologic abnormality),,disease_ontology,,DOID:3577,,,,,,,,,,,,,,,,,,,Sertoli cell tumor,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002050,"[""osteogenic cell""]",,One of the cell's in the inner layer of the periosteum that forms osseous tissue.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,One of the cell's in the inner layer of the periosteum that forms osseous tissue.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002050,,,,,,,BrendaTissueOBO,,BTO:0002050,,,,,,,,,,,,,,,,,,,osteogenic cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001792,"[""portal vein""]",,"A vein that conducts blood from the digestive organs, spleen, pancreas, and gallbladder to the liver.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000234,,,,,,,,"A vein that conducts blood from the digestive organs, spleen, pancreas, and gallbladder to the liver.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001792,,,,,,,BrendaTissueOBO,,BTO:0001792,,,,,,,,,,,,,,,,,,,portal vein,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400218,"[""Other-UNIQUE family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400218,,,,,,,,,,,,,,,,,,,,,,,,,,,,Other-UNIQUE family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200356,"[""NEK2 gene""]",,"This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_03400197,,,,,,,,"This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200356,,,,,,,,,,,,,,,,4751,NEK2,NEK2A|NLK1,,,,,,,,,,NEK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000629,"[""ink""]",,"The black protective secretion of a cephalopod; The ink is composed mostly of melanin and has been used as the artists pigment, sepia.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The black protective secretion of a cephalopod; The ink is composed mostly of melanin and has been used as the artists pigment, sepia.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000629,,,,,,,BrendaTissueOBO,,BTO:0000629,,,,,,,,,,,,,,,,,,,ink,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004052,"[""bone marrow stem cell""]",,Bone marrow stem cells are the most primitive cells in the marrow. From them all the various types of blood cells are descended.,false,,,http://purl.obolibrary.org/obo/BTO_0002666|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Bone marrow stem cells are the most primitive cells in the marrow. From them all the various types of blood cells are descended.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004052,,,,,,,BrendaTissueOBO,BMSC cell|Knochenmarkstammzelle|Knochenmark-Stammzelle,BTO:0004052,,,,,,,,,,,,,,,,,,,bone marrow stem cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100485,"[""Olfactory receptor 1e2""]",,"An olfactory receptor 1E2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47887] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 1E2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47887] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100485,,,,https://pharos.nih.gov/idg/targets/P47887,,,,,,,,,,,,,OR1E2,OR1E4,,P47887,,,,,,,,Olfactory receptor 1e2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100752,"[""Psychosine receptor""]",,"A psychosine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8IYL9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A psychosine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8IYL9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100752,,,,https://pharos.nih.gov/idg/targets/Q8IYL9,,,,,,,,,,,,,GPR65,TDAG8,,Q8IYL9,,,,,,,,Psychosine receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_29103,"[""potassium(1+)""]",POTASSIUM ION|Potassium(1+) ion|Potassium monocation|K+|Potassium ion(1+)|Potassium cation|Potassium (K+)|InChI=1S/K/q+1|Potassium ion (K+)|Potassium ion (K1+)|K(+)|Potassium (ion)|Kalium|K|Potassium ion(+)|NPYPAHLBTDXSSS-UHFFFAOYSA-N|potassium|[K+]|Potassium(+),A monoatomic monocation obtained from potassium.,false,,,http://purl.obolibrary.org/obo/CHEBI_36916,,,,,,,CiteXplore:1893277|PDBeChem:K|CiteXplore:11401244|KEGG DRUG:D08403|CiteXplore:17883675|Wikipedia:Potassium|CiteXplore:24023812|Gmelin:15203|KEGG COMPOUND:C00238|CiteXplore:297449|MetaCyc:K%2b|HMDB:HMDB00586|NIST Chemistry WebBook:24203-36-9|CiteXplore:9263178,A monoatomic monocation obtained from potassium.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:26219|CHEBI:8345|CHEBI:49685,,potassium(1+) ion|potassium cation|potassium(I) cation|Potassium(1+)|potassium(1+),,chebi_ontology,POTASSIUM ION|Potassium(1+) ion|Potassium monocation|K+|Potassium ion(1+)|Potassium cation|Potassium (K+)|InChI=1S/K/q+1|Potassium ion (K+)|Potassium ion (K1+)|K(+)|Potassium (ion)|Kalium|K|Potassium ion(+)|NPYPAHLBTDXSSS-UHFFFAOYSA-N|potassium|[K+]|Potassium(+),,,CHEBI:29103,,,,,,,,,,,,,,,,,,,,,,,CHEBI:29103,,,,,potassium(1+),,CHEBI:29103,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100743,"[""Prostaglandin e2 receptor ep1 subtype""]",,"A prostaglandin E2 receptor EP1 subtype that is encoded in the genome of human. [PRO:WCB, UniProtKB:P34995] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A prostaglandin E2 receptor EP1 subtype that is encoded in the genome of human. [PRO:WCB, UniProtKB:P34995] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100743,,,,https://pharos.nih.gov/idg/targets/P34995,,,,,,,,,,,,,PTGER1,,,P34995,,,,,,,,Prostaglandin e2 receptor ep1 subtype,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100554,"[""Olfactory receptor 2v2""]",,"An olfactory receptor 2V2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R30] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2V2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96R30] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100554,,,,https://pharos.nih.gov/idg/targets/Q96R30,,,,,,,,,,,,,OR2V2,OR2V3,,Q96R30,,,,,,,,Olfactory receptor 2v2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11512,"[""Budd-Chiari syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_272,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11512,,,,ICD10CM:I82.0|MESH:D006502|SNOMEDCT_US_2016_03_01:38739001|UMLS_CUI:C0019154|SNOMEDCT_US_2016_03_01:195436007,hepatic vein thrombosis,,disease_ontology,,DOID:11512,,,,,,,,,,,,,,,,,,,Budd-Chiari syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11516,"[""hypertensive heart disease""]",,A heart disease that is caused by high blood pressure.,false,,,http://purl.obolibrary.org/obo/DOID_114,,,,,,,,A heart disease that is caused by high blood pressure.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11516,,,,SNOMEDCT_US_2016_03_01:194769003|ICD10CM:I11.9|SNOMEDCT_US_2016_03_01:194772005|ICD9CM:402|UMLS_CUI:C0152105|ICD9CM:402.9|SNOMEDCT_US_2016_03_01:64715009|SNOMEDCT_US_2016_03_01:155297007|ICD10CM:I11,,,disease_ontology,,DOID:11516,,,,,,,,,,,,,,,,,,,hypertensive heart disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100030,"[""Alpha-2a adrenergic receptor""]",,"An alpha-2A adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08913] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300093,,,,,,,,"An alpha-2A adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08913] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100030,,,,https://pharos.nih.gov/idg/targets/P08913,,,,,,,,,,,,,ADRA2A,ADRA2R|ADRAR,,P08913,,,,,,,,Alpha-2a adrenergic receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400452,"[""Polycystin subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400360,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400452,,,,,,,,,,,,,,,,,,,,,,,,,,,,Polycystin subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200521,"[""TESK2 gene""]",,"This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400182,,,,,,,,"This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200521,,,,,,,,,,,,,,,,10420,TESK2,,,,,,,,,,,TESK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003848,"[""adenoid cystic carcinoma cell""]",,"A type of cancer that most often develops in the salivary glands of the head and neck. It may arise in other sites such as the skin, lacrimal gland, trachea, breast, cervix and prostate.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002773,,,,,,,,"A type of cancer that most often develops in the salivary glands of the head and neck. It may arise in other sites such as the skin, lacrimal gland, trachea, breast, cervix and prostate.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003848,,,,,,,BrendaTissueOBO,adenoid cystic cancer cell,BTO:0003848,,,,,,,,,,,,,,,,,,,adenoid cystic carcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12785,"[""diabetic polyneuropathy""]",,,false,,,http://purl.obolibrary.org/obo/DOID_9743,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12785,,,,MESH:D003929|ICD9CM:357.2|SNOMEDCT_US_2016_03_01:193182005|UMLS_CUI:C0271680|SNOMEDCT_US_2016_03_01:190349003|SNOMEDCT_US_2016_03_01:49455004,Polyneuropathy in diabetes|Diabetic polyneuropathy (disorder)|Diabetes mellitus with polyneuropathy,,disease_ontology,,DOID:12785,,,,,,,,,,,,,,,,,,,diabetic polyneuropathy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12783,"[""migraine without aura""]",,A migraine that is characterized by migraine headaches that are not accompanied by an aura.,false,,,http://purl.obolibrary.org/obo/DOID_6364,,,,,,,,A migraine that is characterized by migraine headaches that are not accompanied by an aura.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12783,,,,OMIM:607501|SNOMEDCT_US_2016_03_01:56097005|MESH:D020326|NCI:C117004|ICD9CM:346.1|ICD10CM:G43.0|ICD10CM:G43.009|SNOMEDCT_US_2016_03_01:193029000|SNOMEDCT_US_2016_03_01:193027003|UMLS_CUI:C0338480,common migraine,,disease_ontology,,DOID:12783,,,,,,,,,,,,,,,,,Xref MGI.,,migraine without aura,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200599,"[""OR4M1 gene""]",,"An olfactory receptor 4M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4M1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGD0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200599,,,,,,,,,,,,,,,,441670,OR4M1,,,,,,,,,,,OR4M1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000409,"[""SIK2 kinase domain""]",,Serine/threonine-protein kinase SIK2; salt-inducible kinase 2; DKFZp434K1115; KIAA0781; LOH11CR1I; QIK; SIK2; SNF1LK2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase SIK2; salt-inducible kinase 2; DKFZp434K1115; KIAA0781; LOH11CR1I; QIK; SIK2; SNF1LK2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000409,,,,,,,,,,,,,,,,,,,200411,,,,,,,,,SIK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100186,"[""Potassium voltage-gated channel subfamily A member 7""]",,"A voltage-gated potassium channel subunit KCNA7 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q96RP8] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300538,,,,,,,,"A voltage-gated potassium channel subunit KCNA7 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q96RP8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100186,,,,https://pharos.nih.gov/idg/targets/Q96RP8,,,,,,,,,,,,,KCNA7,,,Q96RP8,,,,,,,,Potassium voltage-gated channel subfamily A member 7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100335,"[""Olfactory receptor 11h12""]",,"An olfactory receptor 11H12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:B2RN74] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 11H12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:B2RN74] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100335,,,,https://pharos.nih.gov/idg/targets/B2RN74,,,,,,,,,,,,,OR11H12,,,B2RN74,,,,,,,,Olfactory receptor 11h12,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100227,"[""Hydroxycarboxylic acid receptor 1""]",,"A hydroxycarboxylic acid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BXC0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300060,,,,,,,,"A hydroxycarboxylic acid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BXC0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100227,,,,https://pharos.nih.gov/idg/targets/Q9BXC0,,,,,,,,,,,,,HCAR1,GPR104|GPR81|HCA1,,Q9BXC0,,,,,,,,Hydroxycarboxylic acid receptor 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300290,"[""MARK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300116,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300290,,,,,,,,,,,,,,,,,,,,,,,,,,,,MARK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300035,"[""Cannabinoid receptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300035,,,,,,,,,,,,,,,,,,,,,,,,,,,,Cannabinoid receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200178,"[""GPR15 gene""]",,"A G-protein coupled receptor 15 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49685] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A G-protein coupled receptor 15 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49685] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200178,,,,,,,,,,,,,,,,2838,GPR15,,,,,,,,,,,GPR15 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200541,"[""TSSK2 gene""]",,"TSSK2 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400238,,,,,,,,"TSSK2 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200541,,,,,,,,,,,,,,,,23617,TSSK2,DGSG|SPOGA2|STK22B,,,,,,,,,,TSSK2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391015,"[""Thymidine kinase family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300322,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391015,,,,,,,,,,,,,,,,,,,,,,,,,,,,Thymidine kinase family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400356,"[""Voltage-gated potassium channel -subunit (kv) family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400356,,,,,,,,,,,,,,,,,,,,,,,,,,,,Voltage-gated potassium channel -subunit (kv) family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100048,"[""R858 and M790 in EGFR(L858R,T790M)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100048,,,,,,,,,,,,,,,,,,,,,,,,,,,,"R858 and M790 in EGFR(L858R,T790M)",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100089,"[""Dual specificity protein kinase clk4""]",,"A dual specificity protein kinase CLK4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HAZ1] |dual specificity protein kinase clk4 (CLK4)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300140,,,,,,,,"A dual specificity protein kinase CLK4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HAZ1] |dual specificity protein kinase clk4 (CLK4)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100089,,,,https://pharos.nih.gov/idg/targets/Q9HAZ1,,,,,,,,,,,,,CLK4,,,Q9HAZ1,,,,,,,,Dual specificity protein kinase clk4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100305,"[""Map/microtubule affinity-regulating kinase 4""]",,"A MAP/microtubule affinity-regulating kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96L34] |MAP/microtubule affinity-regulating kinase 4 (MARK4)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300290,,,,,,,,"A MAP/microtubule affinity-regulating kinase 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96L34] |MAP/microtubule affinity-regulating kinase 4 (MARK4)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100305,,,,https://pharos.nih.gov/idg/targets/Q96L34,,,,,,,,,,,,,MARK4,KIAA1860|MARKL1,,Q96L34,,,,,,,,Map/microtubule affinity-regulating kinase 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100282,"[""Plasmolipin""]",,"A plasmolipin that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y342] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,"A plasmolipin that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y342] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100282,,,,https://pharos.nih.gov/idg/targets/Q9Y342,,,,,,,,,,,,,PLLP,PMLP|TM4SF11,,Q9Y342,,,,,,,,Plasmolipin,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400155,"[""FAK family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400155,,,,,,,,,,,,,,,,,,,,,,,,,,,,FAK family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003281,"[""planktonic cell""]",,A plankton-like cell. That means the passively floating or weakly swimming usually minute animal and plant life of a body of water.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002322,,,,,,,,A plankton-like cell. That means the passively floating or weakly swimming usually minute animal and plant life of a body of water.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003281,,,,,,,BrendaTissueOBO,,BTO:0003281,,,,,,,,,,,,,,,,,,,planktonic cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200289,"[""SCN1A gene""]",,"The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, mainly in nerve and muscle. Voltage-sensitive sodium channels are heteromeric complexes consisting of a large central pore-forming glycosylated alpha subunit, and two smaller auxiliary beta subunits. This gene encodes the large alpha subunit, and mutations in this gene have been associated with several epilepsy, convulsion and migraine disorders. Alternative splicing results in multiple transcript variants. The RefSeq Project has decided to create four representative RefSeq records. Three of the transcript variants are supported by experimental evidence and the fourth contains alternate 5' untranslated exons, the exact combination of which have not been experimentally confirmed for the full-length transcript.[provided by RefSeq, Jan 2011]",false,,,http://www.drugtargetontology.org/dto/DTO_01400463,,,,,,,,"The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, mainly in nerve and muscle. Voltage-sensitive sodium channels are heteromeric complexes consisting of a large central pore-forming glycosylated alpha subunit, and two smaller auxiliary beta subunits. This gene encodes the large alpha subunit, and mutations in this gene have been associated with several epilepsy, convulsion and migraine disorders. Alternative splicing results in multiple transcript variants. The RefSeq Project has decided to create four representative RefSeq records. Three of the transcript variants are supported by experimental evidence and the fourth contains alternate 5' untranslated exons, the exact combination of which have not been experimentally confirmed for the full-length transcript.[provided by RefSeq, Jan 2011]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200289,,,,,,,,,,,,,,,,6323,SCN1A,NAC1|SCN1,,,,,,,,,,SCN1A gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000050,"[""Neuromedin S-33""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000050,,,,,,,,,,,,,,,,,,,,,,,,,,,,Neuromedin S-33,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100293,"[""Olfactory receptor 10A7""]",,"An olfactory receptor 10A7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE5] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10A7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGE5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100293,,,,https://pharos.nih.gov/idg/targets/Q8NGE5,,,,,,,,,,,,,OR10A7,,,Q8NGE5,,,,,,,,Olfactory receptor 10A7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200593,"[""IP6K3 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03491041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200593,,,,,,,,,,,,,,,,,,,,,,,,,,,,IP6K3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2213,"[""hemorrhagic disease""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1247,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2213,,,,MESH:D006474|SNOMEDCT_US_2016_03_01:191437009|UMLS_CUI:C0019087|SNOMEDCT_US_2016_03_01:191331006|ICD9CM:287.9|ICD10CM:D69.9|SNOMEDCT_US_2016_03_01:191327000|SNOMEDCT_US_2016_03_01:268884000,Hemorrhagic diathesis|Hemorrhagic disease,,disease_ontology,,DOID:2213,,,,,,,,,,,,,,,,,,,hemorrhagic disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200549,"[""OR2T5 gene""]",,"An olfactory receptor 2T5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IEZ7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2T5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IEZ7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200549,,,,,,,,,,,,,,,,401993,OR2T5,,,,,,,,,,,OR2T5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000235,"[""MET98 in CAMK1D""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000235,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET98 in CAMK1D,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200237,"[""LGR6 gene""]",,"A leucine-rich repeat-containing G-protein coupled receptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HBX8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A leucine-rich repeat-containing G-protein coupled receptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HBX8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200237,,,,,,,,,,,,,,,,59352,LGR6,,,,,,,,,,,LGR6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002348,"[""toe""]",,1. Any of the five digits of the foot. 2. The anterior part of a horse's hoof.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,1. Any of the five digits of the foot. 2. The anterior part of a horse's hoof.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002348,,,,,,,BrendaTissueOBO,hindlimb digit|digitipedis,BTO:0002348,,,,,,,,,,,,,,,,,,,toe,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9146,"[""visceral leishmaniasis""]",,"A leishmaniasis that is the most severe form of the disease caused by protozoan parasites of the Leishmania genus, resulting in the infection of the internal organs such as liver, spleen and bone marrow. The symptoms include fever, weight loss, and an enlarged spleen and liver.",false,,,http://purl.obolibrary.org/obo/DOID_9065,,,,,,,,"A leishmaniasis that is the most severe form of the disease caused by protozoan parasites of the Leishmania genus, resulting in the infection of the internal organs such as liver, spleen and bone marrow. The symptoms include fever, weight loss, and an enlarged spleen and liver.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9146,,,,OMIM:608207|UMLS_CUI:C0023290|NCI:C34771|ICD10CM:B55.0|MESH:D007898|ICD9CM:085.0|SNOMEDCT_US_2016_03_01:186803007|ORDO:507|OMIM:611382|OMIM:611381|SNOMEDCT_US_2016_03_01:48115004,Kala-Azar|Infection by visceral leishmaniasis,,disease_ontology,,DOID:9146,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,Xref MGI.,,visceral leishmaniasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_36916,"[""Cation""]",cationes|Kation|cations|.|Kationen,"
A monoatomic or polyatomic species having one or more elementary charges of the proton.
",false,,,http://purl.obolibrary.org/obo/CHEBI_24870,,,,,,,KEGG COMPOUND:C01373,"
A monoatomic or polyatomic species having one or more elementary charges of the proton.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:3473|CHEBI:23058,,cation|Cation,,chebi_ontology,cationes|Kation|cations|.|Kationen,,,CHEBI:36916,,,,,,,,,,,,,,,,,,,,,,,CHEBI:36916,,,,,cation|Cation,,CHEBI:36916,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200577,"[""OR4D1 gene""]",,"An olfactory receptor 4D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15615] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15615] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200577,,,,,,,,,,,,,,,,26689,OR4D1,OR4D3,,,,,,,,,,OR4D1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100019,"[""I315 in ABL1(T315I)-nonphosphorylated""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100019,,,,,,,,,,,,,,,,,,,,,,,,,,,,I315 in ABL1(T315I)-nonphosphorylated,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200261,"[""MRGPRX1 gene""]",,"A mas-related G-protein coupled receptor X1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96LB2] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400063,,,,,,,,"A mas-related G-protein coupled receptor X1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96LB2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200261,,,,,,,,,,,,,,,,259249,MRGPRX1,MRGX1|SNSR3|SNSR4,,,,,,,,,,MRGPRX1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000014,"[""GLN626 in JAK2(Kin.Dom.2)""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30011,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000014,,,,,,,,,,,,,,,,,,,,,,,,,,,,GLN626 in JAK2(Kin.Dom.2),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_5411,"[""lung oat cell carcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5409,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:5411,,,,SNOMEDCT_US_2016_03_01:189555001|NCI:C3915|SNOMEDCT_US_2016_03_01:76817009|UMLS_CUI:C0262584|SNOMEDCT_US_2016_03_01:74364000|MESH:D018288,poorly differentiated Endocrine neoplasm|Oat cell carcinoma (morphologic abnormality)|oat cell carcinoma,,disease_ontology,,DOID:5411,,,,,,,,,,,,,,,,,,,lung oat cell carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200705,"[""OR8K3 gene""]",,"An olfactory receptor 8K3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH51] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 8K3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH51] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200705,,,,,,,,,,,,,,,,219473,OR8K3,,,,,,,,,,,OR8K3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200550,"[""OR2T6 gene""]",,"An olfactory receptor 2T6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHC8] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 2T6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHC8] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200550,,,,,,,,,,,,,,,,254879,OR2T6,OR2T6P|OR2T9,,,,,,,,,,OR2T6 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300279,"[""PKC iota subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300175,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300279,,,,,,,,,,,,,,,,,,,,,,,,,,,,PKC iota subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200286,"[""NTSR1 gene""]",,"A neurotensin receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30989] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400072,,,,,,,,"A neurotensin receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30989] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200286,,,,,,,,,,,,,,,,4923,NTSR1,NTRR,,,,,,,,,,NTSR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200290,"[""SCN1B gene""]",,"Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]",false,,,http://www.drugtargetontology.org/dto/DTO_01400464,,,,,,,,"Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200290,,,,,,,,,,,,,,,,6324,SCN1B,,,,,,,,,,,SCN1B gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9258,"[""Waardenburg's syndrome""]",,"An autosomal disease characterized by varying degrees of deafness, minor defects in structures arising from the neural crest and pigmentation anomalies of the hair, the skin and/or the iris of both eyes.",false,,,http://purl.obolibrary.org/obo/DOID_0050736,,,,,,,,"An autosomal disease characterized by varying degrees of deafness, minor defects in structures arising from the neural crest and pigmentation anomalies of the hair, the skin and/or the iris of both eyes.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9258,,,,SNOMEDCT_US_2016_03_01:47434006|OMIM:600193|OMIM:608890|ORDO:3440|OMIM:613266|NCI:C75008|UMLS_CUI:C0079661|MESH:D014849|OMIM:193500|UMLS_CUI:C1847800|OMIM:193510|OMIM:613265|ORDO:894|OMIM:606662|ORDO:896|OMIM:611584|UMLS_CUI:C3266898|NCI:C85222|OMIM:148820|ORDO:895|OMIM:277580,"van der Hoeve Halbertsona Waardenburg syndrome|Waardenburg Shah syndrome|Waardenburg syndrome|Waardenburg, types I and/or II|Waardenburg-Klein syndrome",,disease_ontology,,DOID:9258,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,Waardenburg's syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200452,"[""OR5AR1 gene""]",,"An olfactory receptor 5AR1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5AR1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200452,,,,,,,,,,,,,,,,219493,OR5AR1,,,,,,,,,,,OR5AR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060074,"[""ductal carcinoma in situ""]",,,false,,,http://purl.obolibrary.org/obo/DOID_8791,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060074,lschriml,2011-06-08T12:19:28Z,,,,,disease_ontology,,DOID:0060074,,,,,,,,,,,,,,,,,,,ductal carcinoma in situ,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060071,"[""pre-malignant neoplasm""]",,"A disease of cellular proliferation that results in abnormal growths in the body, which do not invade or destroy the surrounding tissue but, given enough time, will transform into a cancer.",false,,,http://purl.obolibrary.org/obo/DOID_14566,,,,,,,,"A disease of cellular proliferation that results in abnormal growths in the body, which do not invade or destroy the surrounding tissue but, given enough time, will transform into a cancer.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060071,lschriml,2011-05-11T12:18:41Z,,,,,disease_ontology,,DOID:0060071,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,pre-malignant neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060073,"[""lymphatic system cancer""]",,An immune system cancer that is located_in the lymphatic system and is characterized by uncontrolled cellular proliferation of lymphoid tissue.,false,,,http://purl.obolibrary.org/obo/DOID_0060083|http://purl.obolibrary.org/obo/DOID_75,,,,,,,,An immune system cancer that is located_in the lymphatic system and is characterized by uncontrolled cellular proliferation of lymphoid tissue.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060073,lschriml,2011-05-11T01:05:14Z,,,,,disease_ontology,,DOID:0060073,,,,,,,,,,,,,,,,,,,lymphatic system cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060072,"[""benign neoplasm""]",,A disease of cellular proliferation that results in abnormal growths in the body which lack the ability to metastasize.,false,,,http://purl.obolibrary.org/obo/DOID_14566,,,,,,,,A disease of cellular proliferation that results in abnormal growths in the body which lack the ability to metastasize.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060072,lschriml,2011-05-11T12:18:41Z,,,,,disease_ontology,,DOID:0060072,http://purl.obolibrary.org/obo/doid#DO_MGI_slim,,,,,,,,,,,,,,,,,,benign neoplasm,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0060075,"[""estrogen-receptor positive breast cancer""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1612,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0060075,lschriml,2011-06-08T12:23:02Z,,,,,disease_ontology,,DOID:0060075,,,,,,,,,,,,,,,,,,,estrogen-receptor positive breast cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300166,"[""IRAK family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300107,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300166,,,,,,,,,,,,,,,,,,,,,,,,,,,,IRAK family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400103,"[""Non-protein kinase gene""]",,A non-protein kinase is a kinase enzyme that modifies any non-protein substrates by chemically adding phosphate groups to them.,false,,,http://www.drugtargetontology.org/dto/DTO_03400101,,,,,,,,A non-protein kinase is a kinase enzyme that modifies any non-protein substrates by chemically adding phosphate groups to them.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400103,,,,,,,,,,,,,,,,,,,,,,,,,,,,Non-protein kinase gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200204,"[""KCNG4 gene""]",,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member functions as a modulatory subunit. The gene has strong expression in brain. Multiple alternatively spliced variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_01400552,,,,,,,,"Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member functions as a modulatory subunit. The gene has strong expression in brain. Multiple alternatively spliced variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200204,,,,,,,,,,,,,,,,93107,KCNG4,KCNG3,,,,,,,,,,KCNG4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217555,"[""NR2C2 gene""]",,"This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]",false,,,http://www.drugtargetontology.org/dto/DTO_00217469,,,,,,,,"This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217555,,,,,,,,,,,,,,,,7182,NR2C2,TAK1|TR4,,,,,,,,,,NR2C2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100635,"[""Pyruvate kinase PKLR""]",,"A pyruvate kinase isozymes R/L that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30613] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300324,,,,,,,,"A pyruvate kinase isozymes R/L that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30613] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100635,,,,https://pharos.nih.gov/idg/targets/P30613,,,,,,,,,,,,,PKLR,,,P30613,,,,,,,,Pyruvate kinase PKLR,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200741,"[""PTGDR2 gene""]",,"A prostaglandin D2 receptor DP2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5Y4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A prostaglandin D2 receptor DP2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5Y4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200741,,,,,,,,,,,,,,,,11251,PTGDR2,CRTH2|DL1R|GPR44,,,,,,,,,,PTGDR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100232,"[""Histamine H3 receptor""]",,"A histamine H3 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5N1] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300061,,,,,,,,"A histamine H3 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y5N1] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100232,,,,https://pharos.nih.gov/idg/targets/Q9Y5N1,,,,,,,,,,,,,HRH3,GPCR97,,Q9Y5N1,,,,,,,,Histamine H3 receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_49713,"[""lithium(1+)""]","Li|LITHIUM ION|InChI=1S/Li/q+1|Li(+)|Li(+) cation|lithium|lithium, ion|Lithium element|Lithium atom|Lithium, ion (Li1+)|HBBGRARXTFLTSG-UHFFFAOYSA-N|lithium cation|Li(+) ion|[Li+]",An alkali metal cation that has formula Li.,false,,,http://purl.obolibrary.org/obo/CHEBI_36916,,,,,,,HMDB:HMDB05949|NIST Chemistry WebBook:17341-24-1|MetaCyc:LI%2b|ChemIDplus:17341-24-1|CiteXplore:17688381|DrugBank:DB01356|CiteXplore:17288494|CiteXplore:16244392|CiteXplore:24023812|CiteXplore:22546835|KEGG COMPOUND:7439-93-2|CiteXplore:17316163|CiteXplore:5256500|Gmelin:15205|CiteXplore:20453535|PDBeChem:LI|CiteXplore:8110911,An alkali metal cation that has formula Li.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,CHEBI:30143|CHEBI:49711,,lithium(1+)|lithium(1+) ion|lithium(I) cation,,chebi_ontology,"Li|LITHIUM ION|InChI=1S/Li/q+1|Li(+)|Li(+) cation|lithium|lithium, ion|Lithium element|Lithium atom|Lithium, ion (Li1+)|HBBGRARXTFLTSG-UHFFFAOYSA-N|lithium cation|Li(+) ion|[Li+]",,,CHEBI:49713,,,,,,,,,,,,,,,,,,,,,,,CHEBI:49713,,,,,lithium(1+),,CHEBI:49713,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000016,"[""ABL1(M351T)-phosphorylated kinase domain""]",,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",false,,,http://www.drugtargetontology.org/dto/DTO_61000015,,,,,,,,"C-abl oncogene 1, receptor tyrosine kinase; ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000016,,,,,,,,,,,,,,,,,,,200015,,,,,,,,,ABL1(M351T)-phosphorylated kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6595,"[""gastric tubular adenocarcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_3717|http://purl.obolibrary.org/obo/DOID_4929,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6595,,,,NCI:C5473|UMLS_CUI:C1333791,tubular adenocarcinoma of stomach,,disease_ontology,,DOID:6595,,,,,,,,,,,,,,,,,,,gastric tubular adenocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001744,"[""jugular vein""]",,Any of several large veins of the neck that drain blood from the head.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000234,,,,,,,,Any of several large veins of the neck that drain blood from the head.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001744,,,,,,,BrendaTissueOBO,vena jugularis,BTO:0001744,,,,,,,,,,,,,,,,,,,jugular vein,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3635,"[""congenital myasthenic syndrome""]",,"A neuromuscular junction disease that is characterized by weakness and easy fatiguability resulting from a genetic defect at the junction where the nerve stimulates muscle activity that result in muscle weakness and may affect nerve cells (presynaptic), muscle cells (postsynaptic) or the space between nerve and muscle cells (synaptic).",false,,,http://purl.obolibrary.org/obo/DOID_439,,,,,,,,"A neuromuscular junction disease that is characterized by weakness and easy fatiguability resulting from a genetic defect at the junction where the nerve stimulates muscle activity that result in muscle weakness and may affect nerve cells (presynaptic), muscle cells (postsynaptic) or the space between nerve and muscle cells (synaptic).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3635,,,,NCI:C84647|SNOMEDCT_US_2016_03_01:230672006|OMIM:PS601462|ORDO:590|UMLS_CUI:C0751882|MESH:D020294,familial limb-girdle myasthenia,,disease_ontology,,DOID:3635,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,Xref MGI.,,congenital myasthenic syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400343,"[""Cyclic nucleotide-gated cation channel family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400343,,,,,,,,,,,,,,,,,,,,,,,,,,,,Cyclic nucleotide-gated cation channel family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03491022,"[""Phosphoenolpyruvate carboxykinase [GTP] family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400324,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03491022,,,,,,,,,,,,,,,,,,,,,,,,,,,,Phosphoenolpyruvate carboxykinase [GTP] family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_09000618,"[""Cathepsin G""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_09000618,,,,,,,,,,,,,,,,,,,,,,,,,,,,Cathepsin G,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100151,"[""Fibroblast growth factor receptor 3""]",,"fibroblast growth factor receptor 3 (FGFR3)  with  no mutation  in a nonphosphorylated state|A fibroblast growth factor receptor 3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P22607] |fibroblast growth factor receptor 3 (FGFR3(G697C))  with  mutation C697 in FGFR3(G697C) in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300158,,,,,,,,"fibroblast growth factor receptor 3 (FGFR3)  with  no mutation  in a nonphosphorylated state|A fibroblast growth factor receptor 3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P22607] |fibroblast growth factor receptor 3 (FGFR3(G697C))  with  mutation C697 in FGFR3(G697C) in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100151,,,,https://pharos.nih.gov/idg/targets/P22607,,,,,,,,,,,,,FGFR3,JTK4,,P22607,,,,,,,,Fibroblast growth factor receptor 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000079,"[""LEU620 in AXL""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000079,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU620 in AXL,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200688,"[""OR8B4 gene""]",,"An olfactory receptor 8B4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RC9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 8B4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RC9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200688,,,,,,,,,,,,,,,,283162,OR8B4,OR8B4P,,,,,,,,,,OR8B4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001090,"[""mouth""]",,"The natural opening through which food passes into the body of an animal and which in vertebrates is typically bounded externally by the lips and internally by the pharynx and encloses the tongue, gums, and teeth.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The natural opening through which food passes into the body of an animal and which in vertebrates is typically bounded externally by the lips and internally by the pharynx and encloses the tongue, gums, and teeth.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001090,,,,,,,BrendaTissueOBO,oral cavity|vestibulum oris|oral fissure|cavitas oris|rima oris|oral vestibule|vestibule of mouth|buccal cavity|cavum oris|mouth cavity,BTO:0001090,,,,,,,,,,,,,,,,,,,mouth,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000155,"[""MET267 in GRK1""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000155,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET267 in GRK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100243,"[""Lysophosphatidic acid receptor 6""]",,"An oleoyl-L-alpha-lysophosphatidic acid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43657] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302007,,,,,,,,"An oleoyl-L-alpha-lysophosphatidic acid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P43657] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100243,,,,https://pharos.nih.gov/idg/targets/P43657,,,,,,,,,,,,,LPAR6,P2RY5,,P43657,,,,,,,,Lysophosphatidic acid receptor 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_75431,"[""ghrelin""]","
CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
|GSSFLSPEHQRVQQRKESKKPPAKLQPR|BGHSOEHUOOAYMY-JTZMCQEISA-N|Ghrelin (human)|Motilin-related peptide|Human ghrelin|
InChI=1S/C141H235N47O41/c1-73(2)62-92(123(213)175-90(42-48-107(150)196)135(225)185-58-22-37-102(185)132(222)176-91(138(228)229)34-21-57-160-141(155)156)177-116(206)79(28-11-15-51-142)164-112(202)76(7)162-130(220)100-35-24-60-187(100)137(227)103-38-25-61-188(103)134(224)89(31-14-18-54-145)174-115(205)81(30-13-17-53-144)168-128(218)97(69-190)181-121(211)87(43-49-109(198)199)170-113(203)80(29-12-16-52-143)165-114(204)82(32-19-55-158-139(151)152)166-117(207)84(39-45-104(147)193)169-119(209)86(41-47-106(149)195)173-133(223)111(75(5)6)184-122(212)83(33-20-56-159-140(153)154)167-118(208)85(40-46-105(148)194)171-126(216)95(65-78-67-157-72-161-78)180-120(210)88(44-50-110(200)201)172-131(221)101-36-23-59-186(101)136(226)99(71-192)183-124(214)93(63-74(3)4)178-125(215)94(64-77-26-9-8-10-27-77)179-129(219)98(70-191)182-127(217)96(68-189)163-108(197)66-146/h8-10,26-27,67,72-76,79-103,111,189-192H,11-25,28-66,68-71,142-146H2,1-7H3,(H2,147,193)(H2,148,194)(H2,149,195)(H2,150,196)(H,157,161)(H,162,220)(H,163,197)(H,164,202)(H,165,204)(H,166,207)(H,167,208)(H,168,218)(H,169,209)(H,170,203)(H,171,216)(H,172,221)(H,173,223)(H,174,205)(H,175,213)(H,176,222)(H,177,206)(H,178,215)(H,179,219)(H,180,210)(H,181,211)(H,182,217)(H,183,214)(H,184,212)(H,198,199)(H,200,201)(H,228,229)(H4,151,152,158)(H4,153,154,159)(H4,155,156,160)/t76-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,111-/m0/s1
|C141H235N47O41|Gastric MLTRP|
Gly-Ser-Ser-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg
","
A 28-membered appetite-stimulating polypeptide consisting of Gly, Ser, Ser, Phe, Leu, Ser, Pro, Glu, His, Gln, Arg, Val, Gln, Gln, Arg, Lys, Glu, Ser, Lys, Lys, Pro, Pro, Ala, Lys, Leu, Gln, Pro and Arg residues joined in sequence.
",false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG COMPOUND:C16025|CiteXplore:23524619|Reaxys:10148432|CiteXplore:23278489|CiteXplore:23982275|CiteXplore:23159561|CiteXplore:23652399|CiteXplore:23631903|CiteXplore:23481295|CiteXplore:23178701|CiteXplore:23359315|CiteXplore:23652386|CiteXplore:23804489|CiteXplore:23808302|CiteXplore:23843943|CiteXplore:23317782|CiteXplore:23624808|CiteXplore:23704134|CiteXplore:23778458|CiteXplore:23428971|CiteXplore:23652420|CiteXplore:23965296|CiteXplore:23989358|CiteXplore:23698230|CiteXplore:23316086|Wikipedia:Ghrelin|CiteXplore:23847595|CiteXplore:23307791|ChemIDplus:304853-26-7,"
A 28-membered appetite-stimulating polypeptide consisting of Gly, Ser, Ser, Phe, Leu, Ser, Pro, Glu, His, Gln, Arg, Val, Gln, Gln, Arg, Lys, Glu, Ser, Lys, Lys, Pro, Pro, Ala, Lys, Leu, Gln, Pro and Arg residues joined in sequence.
",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,"
glycyl-L-seryl-L-seryl-L-phenylalanyl-L-leucyl-L-seryl-L-prolyl-L-alpha-glutamyl-L-histidyl-L-glutaminyl-L-arginyl-L-valyl-L-glutaminyl-L-glutaminyl-L-arginyl-L-lysyl-L-alpha-glutamyl-L-seryl-L-lysyl-L-lysyl-L-prolyl-L-prolyl-L-alanyl-L-lysyl-L-leucyl-L-glutaminyl-L-prolyl-L-arginine
",,chebi_ontology,"
CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
|GSSFLSPEHQRVQQRKESKKPPAKLQPR|BGHSOEHUOOAYMY-JTZMCQEISA-N|Ghrelin (human)|Motilin-related peptide|Human ghrelin|
InChI=1S/C141H235N47O41/c1-73(2)62-92(123(213)175-90(42-48-107(150)196)135(225)185-58-22-37-102(185)132(222)176-91(138(228)229)34-21-57-160-141(155)156)177-116(206)79(28-11-15-51-142)164-112(202)76(7)162-130(220)100-35-24-60-187(100)137(227)103-38-25-61-188(103)134(224)89(31-14-18-54-145)174-115(205)81(30-13-17-53-144)168-128(218)97(69-190)181-121(211)87(43-49-109(198)199)170-113(203)80(29-12-16-52-143)165-114(204)82(32-19-55-158-139(151)152)166-117(207)84(39-45-104(147)193)169-119(209)86(41-47-106(149)195)173-133(223)111(75(5)6)184-122(212)83(33-20-56-159-140(153)154)167-118(208)85(40-46-105(148)194)171-126(216)95(65-78-67-157-72-161-78)180-120(210)88(44-50-110(200)201)172-131(221)101-36-23-59-186(101)136(226)99(71-192)183-124(214)93(63-74(3)4)178-125(215)94(64-77-26-9-8-10-27-77)179-129(219)98(70-191)182-127(217)96(68-189)163-108(197)66-146/h8-10,26-27,67,72-76,79-103,111,189-192H,11-25,28-66,68-71,142-146H2,1-7H3,(H2,147,193)(H2,148,194)(H2,149,195)(H2,150,196)(H,157,161)(H,162,220)(H,163,197)(H,164,202)(H,165,204)(H,166,207)(H,167,208)(H,168,218)(H,169,209)(H,170,203)(H,171,216)(H,172,221)(H,173,223)(H,174,205)(H,175,213)(H,176,222)(H,177,206)(H,178,215)(H,179,219)(H,180,210)(H,181,211)(H,182,217)(H,183,214)(H,184,212)(H,198,199)(H,200,201)(H,228,229)(H4,151,152,158)(H4,153,154,159)(H4,155,156,160)/t76-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,111-/m0/s1
|C141H235N47O41|Gastric MLTRP|
Gly-Ser-Ser-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg
",,,CHEBI:75431,,,,,,,,,,,,,,,,,,,,,,,CHEBI:75431,,,,,Ghrelin|ghrelin,,CHEBI:75431,,http://purl.obolibrary.org/obo/chebi.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200336,"[""OR11L1 gene""]",,"An olfactory receptor 11L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX0] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 11L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGX0] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200336,,,,,,,,,,,,,,,,391189,OR11L1,,,,,,,,,,,OR11L1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300433,"[""KCNJ6 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300433,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ6 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200254,"[""RPS6KA4 gene""]",,"This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400281,,,,,,,,"This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200254,,,,,,,,,,,,,,,,8986,RPS6KA4,MSK2,,,,,,,,,,RPS6KA4 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000906,"[""myeloid cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000906,,,,,,,BrendaTissueOBO,,BTO:0000906,,,,,,,,,,,,,,,,,,,myeloid cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200569,"[""WNK3 gene""]",,"This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400244,,,,,,,,"This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200569,,,,,,,,,,,,,,,,65267,WNK3,KIAA1566|PRKWNK3,,,,,,,,,,WNK3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100230,"[""Histamine H1 receptor""]",,"A histamine H1 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35367] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300061,,,,,,,,"A histamine H1 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35367] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100230,,,,https://pharos.nih.gov/idg/targets/P35367,,,,,,,,,,,,,HRH1,,,P35367,,,,,,,,Histamine H1 receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002572,"[""MEF cell""]",,Mouse embryonic fibroblast cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001958,,,,,,,,Mouse embryonic fibroblast cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002572,,,,,,,BrendaTissueOBO,,BTO:0002572,,,,,,,,,,,,,,,,,,,MEF cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005259,"[""oropharyngeal carcinoma cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000790,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005259,XPMUser,2011-10-03T09:15:20Z,,,,,BrendaTissueOBO,,BTO:0005259,,,,,,,,,,,,,,,,,,,oropharyngeal carcinoma cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400225,"[""SGK071 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400225,,,,,,,,,,,,,,,,,,,,,,,,,,,,SGK071 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_05390003,"[""Putative metabolic drug target""]",,,false,,,http://purl.obolibrary.org/obo/PR_000000001,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_05390003,,,,,,,,,,,,,,,,,,,,,,,,,,,,Putative metabolic drug target,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3459,"[""breast carcinoma""]",,A breast cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.,false,,,http://purl.obolibrary.org/obo/DOID_1612|http://purl.obolibrary.org/obo/DOID_305,,,,,,,,A breast cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3459,,,,SNOMEDCT_US_2016_03_01:154513000|UMLS_CUI:C0678222|SNOMEDCT_US_2016_03_01:286898006|SNOMEDCT_US_2016_03_01:254838004|EFO:0000305|NCI:C4872,carcinoma of breast|Mammary carcinoma,,disease_ontology,,DOID:3459,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,breast carcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100732,"[""P2Y purinoceptor 11""]",,"A P2Y purinoceptor 11 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96G91] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300100,,,,,,,,"A P2Y purinoceptor 11 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96G91] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100732,,,,https://pharos.nih.gov/idg/targets/Q96G91,,,,,,,,,,,,,P2RY11,,,Q96G91,,,,,,,,P2Y purinoceptor 11,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62100039,"[""M804 in RET(V804M)""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_62100000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_62100039,,,,,,,,,,,,,,,,,,,,,,,,,,,,M804 in RET(V804M),,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100782,"[""Taste receptor type 2 member 30""]",,"A taste receptor type 2 member 30 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59541] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300014,,,,,,,,"A taste receptor type 2 member 30 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59541] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100782,,,,https://pharos.nih.gov/idg/targets/P59541,,,,,,,,,,,,,TAS2R30,TAS2R47,,P59541,,,,,,,,Taste receptor type 2 member 30,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300396,"[""ClC-2/CLCN2 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300341,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300396,,,,,,,,,,,,,,,,,,,,,,,,,,,,ClC-2/CLCN2 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002502,"[""kinetoplastid""]",,Pertaining or relating to protozoa of the order Kinetoplastida.,false,,,http://purl.obolibrary.org/obo/BTO_0002503|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Pertaining or relating to protozoa of the order Kinetoplastida.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002502,,,,,,,BrendaTissueOBO,,BTO:0002502,,,,,,,,,,,,,,,,,,,kinetoplastid,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001252,"[""tibia""]",,The shin bone: the inner and larger bone of the leg below the knee; it articulates with the femur and head of the fibula above and with the talus below.,false,,,http://purl.obolibrary.org/obo/UBERON_0001474|http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000140,,,,,,,,The shin bone: the inner and larger bone of the leg below the knee; it articulates with the femur and head of the fibula above and with the talus below.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001252,,,,,,,BrendaTissueOBO,,BTO:0001252,,,,,,,,,,,,,,,,,,,tibia,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300163,"[""INSR family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300163,,,,,,,,,,,,,,,,,,,,,,,,,,,,INSR family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_7427,"[""anthrax disease""]",,"A primary bacterial infectious disease that results_in infection located_in skin, located_in lung lymph nodes or located_in gastrointestinal tract, has_material_basis_in Bacillus anthracis, transmitted_by contact with infected animals or animal products, transmitted_by airborne spores or transmitted_by ingestion of undercooked meat from infected animals and has_symptom skin ulcer, has_symptom nausea, has_symptom poor appetite, has_symptom bloody diarrhea, has_symptom fever or has_symptom shortness of breath.",false,,,http://purl.obolibrary.org/obo/DOID_37|http://purl.obolibrary.org/obo/DOID_0050338,,,,,,,,"A primary bacterial infectious disease that results_in infection located_in skin, located_in lung lymph nodes or located_in gastrointestinal tract, has_material_basis_in Bacillus anthracis, transmitted_by contact with infected animals or animal products, transmitted_by airborne spores or transmitted_by ingestion of undercooked meat from infected animals and has_symptom skin ulcer, has_symptom nausea, has_symptom poor appetite, has_symptom bloody diarrhea, has_symptom fever or has_symptom shortness of breath.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:7427,,,,ICD9CM:022|UMLS_CUI:C0003175|SNOMEDCT_US_2016_03_01:409498004|SNOMEDCT_US_2016_03_01:186304006|ICD9CM:022.9|ICD10CM:A22.9|NCI:C84565|SNOMEDCT_US_2016_03_01:154295005|SNOMEDCT_US_2016_03_01:17540007|SNOMEDCT_US_2016_03_01:187302001|ICD10CM:A22|MESH:D000881,,,disease_ontology,,DOID:7427,http://purl.obolibrary.org/obo/doid#gram-positive_bacterial_infectious_disease|http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,anthrax disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100414,"[""Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha""]",,"A phosphatidylinositol 4-phosphate 5-kinase type-1 alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99755] |phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1A)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300323,,,,,,,,"A phosphatidylinositol 4-phosphate 5-kinase type-1 alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99755] |phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1A)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100414,,,,https://pharos.nih.gov/idg/targets/Q99755,,,,,,,,,,,,,PIP5K1A,,,Q99755,,,,,,,,Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100119,"[""Gamma-aminobutyric acid receptor subunit gamma-2""]",,"A gamma-aminobutyric acid receptor subunit gamma-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P18507] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300518,,,,,,,,"A gamma-aminobutyric acid receptor subunit gamma-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P18507] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100119,,,,https://pharos.nih.gov/idg/targets/P18507,,,,,,,,,,,,,GABRG2,,,P18507,,,,,,,,Gamma-aminobutyric acid receptor subunit gamma-2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200238,"[""PRKD1 gene""]",,"PRKD1 is a serine/threonine kinase that regulates a variety of cellular functions, including membrane receptor signaling, transport at the Golgi, protection from oxidative stress at the mitochondria, gene transcription, and regulation of cell shape, motility, and adhesion (summary by Eiseler et al., 2009 [PubMed 19329994]).[supplied by OMIM, Nov 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400176,,,,,,,,"PRKD1 is a serine/threonine kinase that regulates a variety of cellular functions, including membrane receptor signaling, transport at the Golgi, protection from oxidative stress at the mitochondria, gene transcription, and regulation of cell shape, motility, and adhesion (summary by Eiseler et al., 2009 [PubMed 19329994]).[supplied by OMIM, Nov 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200238,,,,,,,,,,,,,,,,5587,PRKD1,PKD|PKD1|PRKCM,,,,,,,,,,PRKD1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100188,"[""Inositol-trisphosphate 3-kinase b""]",,"An inositol-trisphosphate 3-kinase B that is encoded in the genome of human. [PRO:DNx, UniProtKB:P27987] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391019,,,,,,,,"An inositol-trisphosphate 3-kinase B that is encoded in the genome of human. [PRO:DNx, UniProtKB:P27987] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100188,,,,https://pharos.nih.gov/idg/targets/P27987,,,,,,,,,,,,,ITPKB,,,P27987,,,,,,,,Inositol-trisphosphate 3-kinase b,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200637,"[""OR5M3 gene""]",,"An olfactory receptor 5M3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP4] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5M3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGP4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200637,,,,,,,,,,,,,,,,219482,OR5M3,,,,,,,,,,,OR5M3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100218,"[""Potassium channel subfamily k member 6""]",,"A potassium channel subfamily K member 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y257] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300359,,,,,,,,"A potassium channel subfamily K member 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y257] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100218,,,,https://pharos.nih.gov/idg/targets/Q9Y257,,,,,,,,,,,,,KCNK6,TOSS|TWIK2,,Q9Y257,,,,,,,,Potassium channel subfamily k member 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001156,"[""node""]",,The point on a stem at which leaves and buds are attached.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,The point on a stem at which leaves and buds are attached.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001156,,,,,,,BrendaTissueOBO,stem node,BTO:0001156,,,,,,,,,,,,,,,,,,,node,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400371,"[""Tmem38 family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400371,,,,,,,,,,,,,,,,,,,,,,,,,,,,Tmem38 family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200176,"[""GPER1 gene""]",,"A G-protein coupled estrogen receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99527] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400056,,,,,,,,"A G-protein coupled estrogen receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99527] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200176,,,,,,,,,,,,,,,,2852,GPER1,CEPR|CMKRL2|DRY12|GPER|GPR30,,,,,,,,,,GPER1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100360,"[""Olfactory receptor 2A25""]",,"An olfactory receptor 2A25 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A4D2G3] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2A25 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A4D2G3] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100360,,,,https://pharos.nih.gov/idg/targets/A4D2G3,,,,,,,,,,,,,OR2A25,OR2A25P|OR2A27,,A4D2G3,,,,,,,,Olfactory receptor 2A25,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100395,"[""[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial""]",,"A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15118] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300131,,,,,,,,"A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15118] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100395,,,,https://pharos.nih.gov/idg/targets/Q15118,,,,,,,,,,,,,PDK1,PDHK1,,Q15118,,,,,,,,"[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial",,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200572,"[""OR4C11 gene""]",,"An olfactory receptor 4C11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IEV9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 4C11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IEV9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200572,,,,,,,,,,,,,,,,219429,OR4C11,OR4C11P,,,,,,,,,,OR4C11 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200349,"[""OR13H1 gene""]",,"An olfactory receptor 13H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG92] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 13H1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NG92] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200349,,,,,,,,,,,,,,,,347468,OR13H1,,,,,,,,,,,OR13H1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300415,"[""GRID2 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300351,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300415,,,,,,,,,,,,,,,,,,,,,,,,,,,,GRID2 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100109,"[""Frizzled-7""]",,"A frizzled-7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75084] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300043,,,,,,,,"A frizzled-7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75084] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100109,,,,https://pharos.nih.gov/idg/targets/O75084,,,,,,,,,,,,,FZD7,,,O75084,,,,,,,,Frizzled-7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300395,"[""ClC-1/CLCN1 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300341,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300395,,,,,,,,,,,,,,,,,,,,,,,,,,,,ClC-1/CLCN1 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_6688,"[""autoimmune lymphoproliferative syndrome""]",,"A hypersensitivity reaction type IV disease that is an inherited disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes). It is characterized by the production of an abnormally large number of lymphocytes. Accumulation of excess lymphocytes results in enlargement of the lymph nodes, the liver, and the spleen.",false,,,http://purl.obolibrary.org/obo/DOID_2916,,,,,,,,"A hypersensitivity reaction type IV disease that is an inherited disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes). It is characterized by the production of an abnormally large number of lymphocytes. Accumulation of excess lymphocytes results in enlargement of the lymph nodes, the liver, and the spleen.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:6688,,,,SNOMEDCT_US_2016_03_01:702444009|ICD9CM:279.41|NCI:C37864|ICD10CM:D47.9|ORDO:3261|OMIM:601859|ICD10CM:D89.82|UMLS_CUI:C1328840|CSP:1560-5548|MESH:D056735,Canale-Smith syndrome|ALPS (autoimmune lymphoproliferative syndrome),,disease_ontology,,DOID:6688,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,autoimmune lymphoproliferative syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100116,"[""Dual specificity tyrosine-phosphorylation-regulated kinase 3""]",,"A dual specificity tyrosine-phosphorylation-regulated kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43781] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300267,,,,,,,,"A dual specificity tyrosine-phosphorylation-regulated kinase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43781] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100116,,,,https://pharos.nih.gov/idg/targets/O43781,,,,,,,,,,,,,DYRK3,,,O43781,,,,,,,,Dual specificity tyrosine-phosphorylation-regulated kinase 3,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400590,"[""TRPV1 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400484,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400590,,,,,,,,,,,,,,,,,,,,,,,,,,,,TRPV1 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4226,"[""endometrial stromal sarcoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_5166,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4226,,,,NCI:C8973|UMLS_CUI:C0206630|SNOMEDCT_US_2016_03_01:70555003|MESH:D018203|SNOMEDCT_US_2016_03_01:699356008,"endometrial stromal sarcoma, high grade|ESS|Undifferentiated endometrial sarcoma",,disease_ontology,,DOID:4226,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,endometrial stromal sarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200323,"[""TRPC5 gene""]",,"This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_01400580,,,,,,,,"This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200323,,,,,,,,,,,,,,,,7224,TRPC5,TRP5,,,,,,,,,,TRPC5 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_0001816,"[""angiosarcoma""]",,"A malignant Vascular tumor that results_in rapidly proliferating, extensively infiltrating anaplastic cells derives_from blood vessels and derived_from the lining of irregular blood-filled spaces.",false,,,http://purl.obolibrary.org/obo/DOID_1115,,,,,,,,"A malignant Vascular tumor that results_in rapidly proliferating, extensively infiltrating anaplastic cells derives_from blood vessels and derived_from the lining of irregular blood-filled spaces.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:0001816,,,DOID:267|DOID:4508,NCI:C9275|UMLS_CUI:C0854893|NCI:C3088|SNOMEDCT_US_2016_03_01:403977003|SNOMEDCT_US_2016_03_01:39000009|MESH:D006394|UMLS_CUI:C0018923|SNOMEDCT_US_2016_03_01:33176006,hemangiosarcoma,,disease_ontology,,DOID:0001816,http://purl.obolibrary.org/obo/doid#NCIthesaurus,,,,,,,,,,,,,,,,,,angiosarcoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100068,"[""Cysteinyl leukotriene receptor 2""]",,"A cysteinyl leukotriene receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NS75] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300033,,,,,,,,"A cysteinyl leukotriene receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NS75] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100068,,,,https://pharos.nih.gov/idg/targets/Q9NS75,,,,,,,,,,,,,CYSLTR2,CYSLT2|CYSLT2R,,Q9NS75,,,,,,,,Cysteinyl leukotriene receptor 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100099,"[""Death-associated protein kinase 2""]",,"death-associated protein kinase 2 (DAPK2)  with  no mutation  in a nonphosphorylated state|A death-associated protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UIK4] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300146,,,,,,,,"death-associated protein kinase 2 (DAPK2)  with  no mutation  in a nonphosphorylated state|A death-associated protein kinase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UIK4] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100099,,,,https://pharos.nih.gov/idg/targets/Q9UIK4,,,,,,,,,,,,,DAPK2,,,Q9UIK4,,,,,,,,Death-associated protein kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00117501,"[""Retinoic acid receptor rxr-alpha""]",,"A retinoic acid receptor RXR-alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P19793] ",false,,,http://www.drugtargetontology.org/dto/DTO_00117468,,,,,,,,"A retinoic acid receptor RXR-alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P19793] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00117501,,,,https://pharos.nih.gov/idg/targets/P19793,,,,,,,,,,,,,RXRA,,,P19793,,,,,,,,Retinoic acid receptor rxr-alpha,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100504,"[""Serine/threonine-protein kinase 38""]",,A serine/threonine-protein kinase 38 that is encoded in the genome of human. [PRO:KER] |serine/threonine-protein kinase 38 (NDR1)  with  no mutation  in a nonphosphorylated state,false,,,http://www.drugtargetontology.org/dto/DTO_03300181,,,,,,,,A serine/threonine-protein kinase 38 that is encoded in the genome of human. [PRO:KER] |serine/threonine-protein kinase 38 (NDR1)  with  no mutation  in a nonphosphorylated state,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100504,,,,https://pharos.nih.gov/idg/targets/Q15208,,,,,,,,,,,,,STK38,NDR1,,Q15208,,,,,,,,Serine/threonine-protein kinase 38,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000566,"[""pancreatic islet cancer cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000566,,,,,,,BrendaTissueOBO,,BTO:0000566,,,,,,,,,,,,,,,,,,,pancreatic islet cancer cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000007,"[""HEK-293 cell""]",,Established from a human primary embryonal kidney transformed by adenovirus type 5.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002733|http://purl.obolibrary.org/obo/BTO_0000067,,,,,,,,Established from a human primary embryonal kidney transformed by adenovirus type 5.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000007,,,,,,,BrendaTissueOBO,HEK293 cell|A-293 cell|human embryonic kidney cell|HEK cell|293 cell|A293 cell|human embryonal kidney cell,BTO:0000007,,,,,,,,,,,,,,,,,,,HEK-293 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80298,"[""Gonadotropin-releasing hormone II""]",GnRH-II|Gonadoliberin-II,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16084,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,GnRH-II|Gonadoliberin-II,,,CHEBI:80298,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80298,,,,,Gonadotropin-releasing hormone II,,CHEBI:80298,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3594,"[""choriocarcinoma""]",,,false,,,http://purl.obolibrary.org/obo/DOID_2021,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3594,,,,NCI:C2948|ICD10CM:C58|SNOMEDCT_US_2016_03_01:44769000|SNOMEDCT_US_2016_03_01:189444004|UMLS_CUI:C0008497|MESH:D002822|SNOMEDCT_US_2016_03_01:188188009,Chorioepithelioma,,disease_ontology,,DOID:3594,,,,,,,,,,,,,,,,,,,choriocarcinoma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12401,"[""intermittent explosive disorder""]",,An impulse control disorder that involves the episodic inability to control violent impulses with a disproportionate degree of aggressiveness.,false,,,http://purl.obolibrary.org/obo/DOID_10937,,,,,,,,An impulse control disorder that involves the episodic inability to control violent impulses with a disproportionate degree of aggressiveness.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12401,,,DOID:9404,UMLS_CUI:C0152183|ICD10CM:F63.81|SNOMEDCT_US_2016_03_01:192096007|SNOMEDCT_US_2016_03_01:231527003|MESH:D007174|NCI:C94332|SNOMEDCT_US_2016_03_01:268757006|SNOMEDCT_US_2016_03_01:192488005|ICD10CM:F60.3|SNOMEDCT_US_2016_03_01:191759005|UMLS_CUI:C0021776|ICD9CM:312.34|ICD9CM:301.3|SNOMEDCT_US_2016_03_01:40987004,explosive personality disorder,,disease_ontology,,DOID:12401,,,,,,,,,,,,,,,,,,,intermittent explosive disorder,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1240,"[""leukemia""]",,A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells.,false,,,http://purl.obolibrary.org/obo/DOID_2531,,,,,,,,A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1240,,,DOID:9145,SNOMEDCT_US_2016_03_01:190071003|SNOMEDCT_US_2016_03_01:190024009|ICD9CM:208.9|SNOMEDCT_US_2016_03_01:87163000|ICD10CM:C95|UMLS_CUI:C0023418|SNOMEDCT_US_2016_03_01:93143009|ICD10CM:C95.90|SNOMEDCT_US_2016_03_01:190029004|NCI:C3161|ICD10CM:C95.9|MESH:D007938|SNOMEDCT_US_2016_03_01:190025005|SNOMEDCT_US_2016_03_01:154598008|SNOMEDCT_US_2016_03_01:188762002|SNOMEDCT_US_2016_03_01:188767008|ICD9CM:208|SNOMEDCT_US_2016_03_01:255049003,,,disease_ontology,,DOID:1240,http://purl.obolibrary.org/obo/doid#DO_cancer_slim,,,,,,,,,,,,,,,,,,leukemia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02300094,"[""Beta adrenoceptor""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_02300022,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02300094,,,,,,,,,,,,,,,,,,,,,,,,,,,,Beta adrenoceptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200669,"[""OR6S1 gene""]",,"An olfactory receptor 6S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH40] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 6S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH40] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200669,,,,,,,,,,,,,,,,341799,OR6S1,,,,,,,,,,,OR6S1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100227,"[""Ketohexokinase""]",,"A ketohexokinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P50053] ",false,,,http://www.drugtargetontology.org/dto/DTO_03391032,,,,,,,,"A ketohexokinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P50053] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100227,,,,https://pharos.nih.gov/idg/targets/P50053,,,,,,,,,,,,,KHK,,,P50053,,,,,,,,Ketohexokinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100079,"[""Cyclin-dependent kinase-like 4""]",,"A cyclin-dependent kinase-like 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5MAI5] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300138,,,,,,,,"A cyclin-dependent kinase-like 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5MAI5] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100079,,,,https://pharos.nih.gov/idg/targets/Q5MAI5,,,,,,,,,,,,,CDKL4,,,Q5MAI5,,,,,,,,Cyclin-dependent kinase-like 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200139,"[""ERBB2 gene""]",,"This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400152,,,,,,,,"This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200139,,,,,,,,,,,,,,,,2064,ERBB2,HER2|MLN19|NEU,,,,,,,,,,ERBB2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0000031,"[""fruit peduncle""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0000031,,,,,,,BrendaTissueOBO,,BTO:0000031,,,,,,,,,,,,,,,,,,,fruit peduncle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100012,"[""5-hydroxytryptamine receptor 7""]",,"A 5-hydroxytryptamine receptor 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P34969] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302006,,,,,,,,"A 5-hydroxytryptamine receptor 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P34969] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100012,,,,https://pharos.nih.gov/idg/targets/P34969,,,,,,,,,,,,,HTR7,,,P34969,,,,,,,,5-hydroxytryptamine receptor 7,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217562,"[""ESR2 gene""]",,"This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_00217472,,,,,,,,"This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217562,,,,,,,,,,,,,,,,2100,ESR2,ESTRB|NR3A2,,,,,,,,,,ESR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100131,"[""Adhesion G-protein coupled receptor G4""]",,"A G-protein coupled receptor 112 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF6] ",false,,,http://www.drugtargetontology.org/dto/DTO_02302008,,,,,,,,"A G-protein coupled receptor 112 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IZF6] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100131,,,,https://pharos.nih.gov/idg/targets/Q8IZF6,,,,,,,,,,,,,GPR112,ADGRG4,,Q8IZF6,,,,,,,,Adhesion G-protein coupled receptor G4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100509,"[""Olfactory receptor 2A2""]",,"An olfactory receptor 2A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF42] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2A2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IF42] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100509,,,,https://pharos.nih.gov/idg/targets/Q6IF42,,,,,,,,,,,,,OR2A2,OR2A17P|OR2A2P,,Q6IF42,,,,,,,,Olfactory receptor 2A2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300430,"[""KCNJ3 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300353,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300430,,,,,,,,,,,,,,,,,,,,,,,,,,,,KCNJ3 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200355,"[""NEK1 gene""]",,"The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]",false,,,http://www.drugtargetontology.org/dto/DTO_03400197,,,,,,,,"The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200355,,,,,,,,,,,,,,,,4750,NEK1,KIAA1901,,,,,,,,,,NEK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300212,"[""WEE family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300212,,,,,,,,,,,,,,,,,,,,,,,,,,,,WEE family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100242,"[""Potassium channel subfamily U member 1""]",,"A potassium channel subfamily U member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A8MYU2] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300571,,,,,,,,"A potassium channel subfamily U member 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:A8MYU2] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100242,,,,https://pharos.nih.gov/idg/targets/A8MYU2,,,,,,,,,,,,,KCNU1,KCNMA3|KCNMC1|SLO3,,A8MYU2,,,,,,,,Potassium channel subfamily U member 1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002363,"[""pancreatic ductal carcinoma cell""]",,Carcinoma that arises from the pancreatic ducts. It accounts for the majority of cancers derived from the pancreas.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Carcinoma that arises from the pancreatic ducts. It accounts for the majority of cancers derived from the pancreas.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002363,,,,,,,BrendaTissueOBO,pancreatic duct cell carcinoma cell|ductal carcinoma of the pancreas|duct-cell carcinoma cell of the pancreas|pancreas duct-cell carcinoma cell|PDC cell|duct cell carcinoma cell of the pancreas,BTO:0002363,,,,,,,,,,,,,,,,,,,pancreatic ductal carcinoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005454,"[""corpus cavernosum""]",,Either of the columns of erectile tissue forming the body of the clitoris or penis.,false,,,http://purl.obolibrary.org/obo/BTO_0000081|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Either of the columns of erectile tissue forming the body of the clitoris or penis.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005454,XPMUser,2013-09-06T09:39:31Z,,,,,BrendaTissueOBO,,BTO:0005454,,,,,,,,,,,,,,,,,,,corpus cavernosum,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200494,"[""STK38L gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400181,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200494,,,,,,,,,,,,,,,,23012,STK38L,KIAA0965|NDR2,,,,,,,,,,STK38L gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100273,"[""Leucine-rich repeat serine/threonine-protein kinase 2""]",,"leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2(G2019S))  with  mutation S2019 in LRRK2(G2019S) in a nonphosphorylated state|leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)  with  no mutation  in a nonphosphorylated state|A leucine-rich repeat serine/threonine-protein kinase 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q5S007] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300184,,,,,,,,"leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2(G2019S))  with  mutation S2019 in LRRK2(G2019S) in a nonphosphorylated state|leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)  with  no mutation  in a nonphosphorylated state|A leucine-rich repeat serine/threonine-protein kinase 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q5S007] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100273,,,,https://pharos.nih.gov/idg/targets/Q5S007,,,,,,,,,,,,,LRRK2,PARK8,,Q5S007,,,,,,,,Leucine-rich repeat serine/threonine-protein kinase 2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2043,"[""hepatitis B""]",,"A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus, which is transmitted_by sexual contact, transmitted_by blood transfusions, and transmitted_by fomites like needles or syringes. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.",false,,,http://purl.obolibrary.org/obo/DOID_37|http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus, which is transmitted_by sexual contact, transmitted_by blood transfusions, and transmitted_by fomites like needles or syringes. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2043,,,DOID:2042|DOID:12592|DOID:12591,MESH:D019694|UMLS_CUI:C0019163|NCI:C3097|MESH:D006509|SNOMEDCT_US_2016_03_01:66071002|EFO:0004197|SNOMEDCT_US_2016_03_01:186625003|SNOMEDCT_US_2016_03_01:266195001|SNOMEDCT_US_2016_03_01:154348008,hepatitis B infection|chronic hepatitis B,,disease_ontology,Serum hepatitis,DOID:2043,http://purl.obolibrary.org/obo/doid#sexually_transmitted_infectious_disease,,,,,,,,,,,,,,,,,,hepatitis B,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200429,"[""PKN3 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400210,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200429,,,,,,,,,,,,,,,,29941,PKN3,PKNBETA,,,,,,,,,,PKN3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3343,"[""glycoproteinosis""]",,A lysosomal storage disease that is characterized by a deficiency of the enzyme alpha-N -acetyl neuraminidase (sialidase).,false,,,http://purl.obolibrary.org/obo/DOID_3211,,,,,,,,A lysosomal storage disease that is characterized by a deficiency of the enzyme alpha-N -acetyl neuraminidase (sialidase).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3343,,,,ICD10:E77.1|OMIM:256550|UMLS_CUI:C0026697|NCI:C61267|SNOMEDCT_US_2016_03_01:70528007|MESH:D009081,Mucolipidosis type I|sialidosis,,disease_ontology,,DOID:3343,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,OMIM mapping submitted by NeuroDevNet. [LS].,,glycoproteinosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100214,"[""G-protein coupled receptor 87""]",,"A G-protein coupled receptor 87 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BY21] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300053,,,,,,,,"A G-protein coupled receptor 87 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9BY21] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100214,,,,https://pharos.nih.gov/idg/targets/Q9BY21,,,,,,,,,,,,,GPR87,GPR95,,Q9BY21,,,,,,,,G-protein coupled receptor 87,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0005578,"[""lymphangioleiomyomatosis disease specific cell type""]",,"Lymphangioleiomyomatosis is a rare lung disease that results in a proliferation of disorderly smooth muscle growth (leiomyoma) throughout the lungs, in the bronchioles, alveolar septa, perivascular spaces, and lymphatics, resulting in the obstruction of small airways (leading to pulmonary cyst formation and pneumothorax) and lymphatics (leading to chylous pleural effusion).",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0005577,,,,,,,,"Lymphangioleiomyomatosis is a rare lung disease that results in a proliferation of disorderly smooth muscle growth (leiomyoma) throughout the lungs, in the bronchioles, alveolar septa, perivascular spaces, and lymphatics, resulting in the obstruction of small airways (leading to pulmonary cyst formation and pneumothorax) and lymphatics (leading to chylous pleural effusion).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0005578,Marion,2014-03-02T21:08:53Z,,,,,BrendaTissueOBO,LAM cell,BTO:0005578,,,,,,,,,,,,,,,,,,,lymphangioleiomyomatosis disease specific cell type,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002708,"[""GT1-7 cell""]",,Immortalized female rat hypothalamus gonadotropin-releasing hormone (GnRH) neurons.,false,,,http://purl.obolibrary.org/obo/BTO_0000947|http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,Immortalized female rat hypothalamus gonadotropin-releasing hormone (GnRH) neurons.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002708,,,,,,,BrendaTissueOBO,,BTO:0002708,,,,,,,,,,,,,,,,,,,GT1-7 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100209,"[""Casein kinase i isoform delta""]",,"casein kinase i isoform delta (CSNK1D)  with  no mutation  in a nonphosphorylated state|A casein kinase I isoform delta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48730] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300170,,,,,,,,"casein kinase i isoform delta (CSNK1D)  with  no mutation  in a nonphosphorylated state|A casein kinase I isoform delta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48730] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100209,,,,https://pharos.nih.gov/idg/targets/P48730,,,,,,,,,,,,,CSNK1D,HCKID,,P48730,,,,,,,,Casein kinase i isoform delta,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1395,"[""schistosomiasis""]",,"A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus Schistosoma. The symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria.",false,,,http://purl.obolibrary.org/obo/DOID_883,,,,,,,,"A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus Schistosoma. The symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1395,,,,ICD9CM:120.8|SNOMEDCT_US_2016_03_01:187116001|UMLS_CUI:C0029827|SNOMEDCT_US_2016_03_01:187121003,,,disease_ontology,,DOID:1395,,,,,,,,,,,,,,,,,,,schistosomiasis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3044,"[""food allergy""]",,"A hypersensitivity reaction type I disease that is an abnormal response to a food, triggered by the body's immune system.",false,,,http://purl.obolibrary.org/obo/DOID_1205,,,,,,,,"A hypersensitivity reaction type I disease that is an abnormal response to a food, triggered by the body's immune system.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3044,,,,SNOMEDCT_US_2016_03_01:52332009|UMLS_CUI:C0016470|SNOMEDCT_US_2016_03_01:157801005|MESH:D005512|SNOMEDCT_US_2016_03_01:414285001|SNOMEDCT_US_2016_03_01:213018006,food hypersensitivity,,disease_ontology,,DOID:3044,,,,,,,,,,,,,,,,,,,food allergy,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200307,"[""MAST2 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400160,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200307,,,,,,,,,,,,,,,,23139,MAST2,KIAA0807|MAST205,,,,,,,,,,MAST2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_90,"[""degenerative disc disease""]",,A bone deterioration disease that has_material_basis_in gradual dehydration and tears located_in intervertebral disc.,false,,,http://purl.obolibrary.org/obo/DOID_0080007,,,,,,,,A bone deterioration disease that has_material_basis_in gradual dehydration and tears located_in intervertebral disc.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:90,,,DOID:7943,EFO:0004994|SNOMEDCT_US_2016_03_01:156633005|NCI:C27156|UMLS_CUI:C0410606,cervical disc degenerative disease|intervertebral disc degeneration|vertebral disc disease|lumbar disc degeneration,,disease_ontology,,DOID:90,,,,,,,,,,,,,,,,,,,degenerative disc disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_906,"[""peroxisomal disease""]",,An inherited metabolic disorder that involves peroxisome malfunction.,false,,,http://purl.obolibrary.org/obo/DOID_655,,,,,,,,An inherited metabolic disorder that involves peroxisome malfunction.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:906,,,,UMLS_CUI:C0282528|NCI:C85005|MESH:D018901|ICD10CM:E71.50|ICD9CM:277.86|ICD10CM:E71.5|SNOMEDCT_US_2016_03_01:238059005,peroxisomal disorder,,disease_ontology,,DOID:906,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,peroxisomal disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_900,"[""hepatopulmonary syndrome""]",,,false,,,http://purl.obolibrary.org/obo/DOID_409,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:900,,,,ICD9CM:573.5|ICD10CM:K76.81|MESH:D020065|SNOMEDCT_US_2016_03_01:371067004|UMLS_CUI:C0600452,Hepatopulmonary syndrome (disorder),,disease_ontology,,DOID:900,,,,,,,,,,,,,,,,,,,hepatopulmonary syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_905,"[""Zellweger syndrome""]",,A peroxisomal disease that is characterized by the reduction or absence of functional peroxisomes in the cells of an individual that has_material_basis_in autosomal recessive inheritance of a mutation in the peroxisome biogenesis factor (PEX) genes.,false,,,http://purl.obolibrary.org/obo/DOID_906,,,,,,,,A peroxisomal disease that is characterized by the reduction or absence of functional peroxisomes in the cells of an individual that has_material_basis_in autosomal recessive inheritance of a mutation in the peroxisome biogenesis factor (PEX) genes.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:905,,,,ORDO:912|NCI:C85239|MESH:D015211|ICD10CM:E71.510|SNOMEDCT_US_2016_03_01:88469006|UMLS_CUI:C0043459|OMIM:214100,cerebrohepatorenal syndrome |congenital iron overload|peroxisome biogenesis disorder,,disease_ontology,,DOID:905,http://purl.obolibrary.org/obo/doid#DO_rare_slim|http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,"OMIM mapping confirmed by DO. [LS].
OMIM mapping confirmed by DO. [SN].",,Zellweger syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000032,"[""LEU1157 in MET""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_30006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000032,,,,,,,,,,,,,,,,,,,,,,,,,,,,LEU1157 in MET,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200106,"[""DDR2 gene""]",,"Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400148,,,,,,,,"Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200106,,,,,,,,,,,,,,,,4921,DDR2,NTRKR3|TKT|TYRO10,,,,,,,,,,DDR2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000198,"[""IRAK4 kinase domain""]",,Interleukin-1 receptor-associated kinase 4; IPD1; NY-REN-64; REN64,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Interleukin-1 receptor-associated kinase 4; IPD1; NY-REN-64; REN64,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000198,,,,,,,,,,,,,,,,,,,200201,,,,,,,,,IRAK4 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03391038,"[""SNRK subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300116,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03391038,,,,,,,,,,,,,,,,,,,,,,,,,,,,SNRK subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100041,"[""Tyrosine-protein kinase blk""]",,"tyrosine-protein kinase blk (BLK)  with  no mutation  in a nonphosphorylated state|A tyrosine-protein kinase BLK that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51451] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300132,,,,,,,,"tyrosine-protein kinase blk (BLK)  with  no mutation  in a nonphosphorylated state|A tyrosine-protein kinase BLK that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51451] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100041,,,,https://pharos.nih.gov/idg/targets/P51451,,,,,,,,,,,,,BLK,,,P51451,,,,,,,,Tyrosine-protein kinase blk,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200393,"[""OR51E2 gene""]",,"An olfactory receptor 51E2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H255] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 51E2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H255] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200393,,,,,,,,,,,,,,,,81285,OR51E2,PSGR,,,,,,,,,,OR51E2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100072,"[""Cyclin-dependent kinase 6""]",,"A cyclin-dependent kinase 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q00534] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300260,,,,,,,,"A cyclin-dependent kinase 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q00534] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100072,,,,https://pharos.nih.gov/idg/targets/Q00534,,,,,,,,,,,,,CDK6,CDKN6,,Q00534,,,,,,,,Cyclin-dependent kinase 6,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000072,"[""CDK14 kinase domain""]",,Cyclin-dependent kinase 14; serine/threonine-protein kinase PFTAIRE-1; PFTK1,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Cyclin-dependent kinase 14; serine/threonine-protein kinase PFTAIRE-1; PFTK1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000072,,,,,,,,,,,,,,,,,,,200318,,,,,,,,,CDK14 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1443,"[""cerebral degeneration""]",,,false,,,http://purl.obolibrary.org/obo/DOID_936,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1443,,,,ICD9CM:331.9|UMLS_CUI:C0154671|SNOMEDCT_US_2016_03_01:73768007|SNOMEDCT_US_2016_03_01:267688001|SNOMEDCT_US_2016_03_01:192824002|SNOMEDCT_US_2016_03_01:418143002|SNOMEDCT_US_2016_03_01:267579001|SNOMEDCT_US_2016_03_01:154998003|SNOMEDCT_US_2016_03_01:52522001|SNOMEDCT_US_2016_03_01:267686002|SNOMEDCT_US_2016_03_01:154994001,Brain degeneration,,disease_ontology,,DOID:1443,,,,,,,,,,,,,,,,,,,cerebral degeneration,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000386,"[""RIPK5 kinase domain""]",,Dual serine/threonine and tyrosine protein kinase; DSTYK; DustyPK; HDCMD38P; KIAA0472; RIP5; RIPK5; SgK496,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Dual serine/threonine and tyrosine protein kinase; DSTYK; DustyPK; HDCMD38P; KIAA0472; RIP5; RIPK5; SgK496,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000386,,,,,,,,,,,,,,,,,,,200380,,,,,,,,,RIPK5 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11267,"[""keratomalacia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1237,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11267,,,,ICD9CM:371.45|MESH:C536156|UMLS_CUI:C0152455|SNOMEDCT_US_2016_03_01:85149007|SNOMEDCT_US_2016_03_01:193827004|ICD10CM:H18.44,,,disease_ontology,,DOID:11267,,,,,,,,,,,,,,,,,,,keratomalacia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11266,"[""hemorrhagic fever with renal syndrome""]",,"A viral infectious disease that is a hemorrhagic fever, located_in kidney, has_material_basis_in Hantaan virus, has_material_basis_in Dobrava-Belgrade virus, has_material_basis_in Seoul virus, or has_material_basis_in Puumala virus, which are carried and transmitted_by rodents. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure.",false,,,http://purl.obolibrary.org/obo/DOID_37|http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that is a hemorrhagic fever, located_in kidney, has_material_basis_in Hantaan virus, has_material_basis_in Dobrava-Belgrade virus, has_material_basis_in Seoul virus, or has_material_basis_in Puumala virus, which are carried and transmitted_by rodents. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11266,,,,MESH:D006480|ICD10CM:A98.5|SNOMEDCT_US_2016_03_01:102455002|ICD9CM:078.6|UMLS_CUI:C0019101|NCI:C84753|SNOMEDCT_US_2016_03_01:186701001|SNOMEDCT_US_2016_03_01:364756009|SNOMEDCT_US_2016_03_01:70826003,"Hemorrhagic fever, Russian|Puumala virus nephropathy (disorder)|Hemorrhagic nephrosonephritis|HFRS",,disease_ontology,,DOID:11266,http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,hemorrhagic fever with renal syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11260,"[""rabies""]",,"A viral infectious disease that results_in inflammation located_in brain or located_in spinal cord, has_material_basis_in Rabies virus, which is transmitted_by bite of an infected animal, or transmitted_by contact of mucous membranes with saliva of an infected animal. The infection has_symptom fever, has_symptom headache, has_symptom prickling or itching sensation at the site of bite, has_symptom anxiety, has_symptom confusion, has_symptom agitation, has_symptom delirium, has_symptom difficulty swallowing, has_symptom hydrophobia, and has_symptom paralysis.",false,,,http://purl.obolibrary.org/obo/DOID_934,,,,,,,,"A viral infectious disease that results_in inflammation located_in brain or located_in spinal cord, has_material_basis_in Rabies virus, which is transmitted_by bite of an infected animal, or transmitted_by contact of mucous membranes with saliva of an infected animal. The infection has_symptom fever, has_symptom headache, has_symptom prickling or itching sensation at the site of bite, has_symptom anxiety, has_symptom confusion, has_symptom agitation, has_symptom delirium, has_symptom difficulty swallowing, has_symptom hydrophobia, and has_symptom paralysis.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11260,,,,SNOMEDCT_US_2016_03_01:14168008|SNOMEDCT_US_2016_03_01:275370001|ICD10CM:A82|SNOMEDCT_US_2016_03_01:186644005|UMLS_CUI:C0034494|ICD9CM:071|ICD10CM:A82.9|NCI:C28182|SNOMEDCT_US_2016_03_01:187393002|MESH:D011818,Lyssa,,disease_ontology,,DOID:11260,http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,rabies,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_11262,"[""ornithosis""]",,"A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Chlamydia psittaci, which is transmitted_by inhaling aerosolized dried droppings or transmitted_by contact with infected birds. The infection has_symptom fever, has_symptom headache, has_symptom rash, has_symptom chills, and has_symptom pneumonia.",false,,,http://purl.obolibrary.org/obo/DOID_0050338,,,,,,,,"A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Chlamydia psittaci, which is transmitted_by inhaling aerosolized dried droppings or transmitted_by contact with infected birds. The infection has_symptom fever, has_symptom headache, has_symptom rash, has_symptom chills, and has_symptom pneumonia.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:11262,,,,SNOMEDCT_US_2016_03_01:154367007|SNOMEDCT_US_2016_03_01:266200005|ICD9CM:073|UMLS_CUI:C0029291|SNOMEDCT_US_2016_03_01:186653003|ICD9CM:073.9|MESH:D009956|SNOMEDCT_US_2016_03_01:75116005|SNOMEDCT_US_2016_03_01:154369005|ICD10CM:A70|NCI:C34873|SNOMEDCT_US_2016_03_01:186657002,psittacosis,,disease_ontology,,DOID:11262,http://purl.obolibrary.org/obo/doid#gram-negative_bacterial_infectious_disease|http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease,,,,,,,,,,,,,,,,,,ornithosis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100534,"[""Olfactory receptor 2l2""]",,"An olfactory receptor 2L2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH16] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2L2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH16] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100534,,,,https://pharos.nih.gov/idg/targets/Q8NH16,,,,,,,,,,,,,OR2L2,OR2L12|OR2L4P,,Q8NH16,,,,,,,,Olfactory receptor 2l2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003800,"[""PCCL-3 cell""]",,Normal rat thyroid cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001876,,,,,,,,Normal rat thyroid cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003800,,,,,,,BrendaTissueOBO,PCCl3 cell|PCCL3 cell,BTO:0003800,,,,,,,,,,,,,,,,,,,PCCL-3 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100087,"[""Dual specificity protein kinase clk2""]",,"A dual specificity protein kinase CLK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49760] |dual specificity protein kinase clk2 (CLK2)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300140,,,,,,,,"A dual specificity protein kinase CLK2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49760] |dual specificity protein kinase clk2 (CLK2)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100087,,,,https://pharos.nih.gov/idg/targets/P49760,,,,,,,,,,,,,CLK2,,,P49760,,,,,,,,Dual specificity protein kinase clk2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001057,"[""neural tube""]",,A dorsal tubular structure in the vertebrate embryo formed by longitudinal folding of the neural plate and differentiating into the brain and spinal cord.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,A dorsal tubular structure in the vertebrate embryo formed by longitudinal folding of the neural plate and differentiating into the brain and spinal cord.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001057,,,,,,,BrendaTissueOBO,,BTO:0001057,,,,,,,,,,,,,,,,,,,neural tube,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80340,"[""Adrenomedullin 2""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16128,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80340,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80340,,,,,Adrenomedullin 2,,CHEBI:80340,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2382,"[""kernicterus""]",,A brain disease that is characterized by hyperbilirubinemia-induced brain dysfunction.,false,,,http://purl.obolibrary.org/obo/DOID_936,,,,,,,,A brain disease that is characterized by hyperbilirubinemia-induced brain dysfunction.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2382,,,,ICD10CM:P57|UMLS_CUI:C0022610|MESH:D007647|SNOMEDCT_US_2016_03_01:230770008|SNOMEDCT_US_2016_03_01:206479002|SNOMEDCT_US_2016_03_01:268880009|SNOMEDCT_US_2016_03_01:74925009|ICD10CM:P57.9|SNOMEDCT_US_2016_03_01:157135006|SNOMEDCT_US_2016_03_01:50143004|NCI:C84799,bilirubin encephalopathy,,disease_ontology,,DOID:2382,,,,,,,,,,,,,,,,,,,kernicterus,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000092,"[""CLK3 kinase domain""]",,Dual specificity protein kinase CLK3; CDC-like kinase 3; CLK3; FLJ22858; PHCLK3; PHCLK3/152,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Dual specificity protein kinase CLK3; CDC-like kinase 3; CLK3; FLJ22858; PHCLK3; PHCLK3/152,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000092,,,,,,,,,,,,,,,,,,,200092,,,,,,,,,CLK3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100264,"[""Mas-related G-protein coupled receptor member X4""]",,"A mas-related G-protein coupled receptor X4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96LA9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300063,,,,,,,,"A mas-related G-protein coupled receptor X4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96LA9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100264,,,,https://pharos.nih.gov/idg/targets/Q96LA9,,,,,,,,,,,,,MRGPRX4,MRGX4|SNSR5|SNSR6,,Q96LA9,,,,,,,,Mas-related G-protein coupled receptor member X4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001391,"[""tracheal smooth muscle""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0001660,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001391,,,,,,,BrendaTissueOBO,,BTO:0001391,,,,,,,,,,,,,,,,,,,tracheal smooth muscle,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004148,"[""cervical spine""]",,That portion of the spine comprising the cervical vertebrae. The neck area of the spine.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,That portion of the spine comprising the cervical vertebrae. The neck area of the spine.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004148,,,,,,,BrendaTissueOBO,,BTO:0004148,,,,,,,,,,,,,,,,,,,cervical spine,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200368,"[""NRBP1 gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400198,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200368,,,,,,,,,,,,,,,,29959,NRBP1,BCON3|NRBP,,,,,,,,,,NRBP1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_4479,"[""pseudohypoaldosteronism""]",,,false,,,http://purl.obolibrary.org/obo/DOID_447,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:4479,,,,UMLS_CUI:C0033805|MESH:D011546|NCI:C85034|SNOMEDCT_US_2016_03_01:77098009,,,disease_ontology,,DOID:4479,http://purl.obolibrary.org/obo/doid#DO_FlyBase_slim,,,,,,,,,,,,,,,,,,pseudohypoaldosteronism,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100110,"[""Gamma-aminobutyric acid receptor subunit alpha-4""]",,"A gamma-aminobutyric acid receptor subunit alpha-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48169] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300509,,,,,,,,"A gamma-aminobutyric acid receptor subunit alpha-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48169] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100110,,,,https://pharos.nih.gov/idg/targets/P48169,,,,,,,,,,,,,GABRA4,,,P48169,,,,,,,,Gamma-aminobutyric acid receptor subunit alpha-4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300375,"[""Acetylcholine receptor subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300328,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300375,,,,,,,,,,,,,,,,,,,,,,,,,,,,Acetylcholine receptor subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100468,"[""Delta-type opioid receptor""]",,"A delta-type opioid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41143] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A delta-type opioid receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41143] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100468,,,,https://pharos.nih.gov/idg/targets/P41143,,,,,,,,,,,,,OPRD1,OPRD,,P41143,,,,,,,,Delta-type opioid receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01400575,"[""MCOLN2 sub-subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01400452,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01400575,,,,,,,,,,,,,,,,,,,,,,,,,,,,MCOLN2 sub-subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100121,"[""Gamma-aminobutyric acid receptor subunit pi""]",,"A gamma-aminobutyric acid receptor subunit pi that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00591] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300520,,,,,,,,"A gamma-aminobutyric acid receptor subunit pi that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00591] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100121,,,,https://pharos.nih.gov/idg/targets/O00591,,,,,,,,,,,,,GABRP,,,O00591,,,,,,,,Gamma-aminobutyric acid receptor subunit pi,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_8515,"[""Cor pulmonale""]",,A congestive heart failure that involves a failure of the right side of the heart and is characterized by an enlargement of the right ventricle of the heart as a response to increased resistance or high blood pressure in the lungs.,false,,,http://purl.obolibrary.org/obo/DOID_6000,,,,,,,,A congestive heart failure that involves a failure of the right side of the heart and is characterized by an enlargement of the right ventricle of the heart as a response to increased resistance or high blood pressure in the lungs.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:8515,,,,ICD10CM:I27.81|UMLS_CUI:C0034072|ICD10CM:I27.9|SNOMEDCT_US_2016_03_01:83291003|SNOMEDCT_US_2016_03_01:194879006|SNOMEDCT_US_2016_03_01:266294009|MESH:D011660|SNOMEDCT_US_2016_03_01:286952009|SNOMEDCT_US_2016_03_01:155329000|SNOMEDCT_US_2016_03_01:155323004|SNOMEDCT_US_2016_03_01:274096000,cardiopulmonary disease|pulmonary heart disease,,disease_ontology,,DOID:8515,,,,,,,,,,,,,,,,,,,Cor pulmonale,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1271,"[""capillary disease""]",,A vascular disease that is located_in the capillaries.,false,,,http://purl.obolibrary.org/obo/DOID_178,,,,,,,,A vascular disease that is located_in the capillaries.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1271,,,,SNOMEDCT_US_2016_03_01:58729003|SNOMEDCT_US_2016_03_01:266324004|SNOMEDCT_US_2016_03_01:195250004|SNOMEDCT_US_2016_03_01:195390003|ICD10CM:I78.9|SNOMEDCT_US_2016_03_01:155449008|UMLS_CUI:C0155765|SNOMEDCT_US_2016_03_01:155446001|SNOMEDCT_US_2016_03_01:57223003|SNOMEDCT_US_2016_03_01:195380006|ICD9CM:448|ICD10CM:I78,disease of capillaries,,disease_ontology,,DOID:1271,,,,,,,,,,,,,,,,,,,capillary disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12716,"[""newborn respiratory distress syndrome""]",,"A respiratory failure that is characterized by deficiency of the surfactant coating the inner surface of the lungs, by failure of the lungs to expand and contract properly during breathing with resulting collapse, and by the accumulation of a protein-containing film lining the alveoli and their ducts.",false,,,http://purl.obolibrary.org/obo/DOID_11162,,,,,,,,"A respiratory failure that is characterized by deficiency of the surfactant coating the inner surface of the lungs, by failure of the lungs to expand and contract properly during breathing with resulting collapse, and by the accumulation of a protein-containing film lining the alveoli and their ducts.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12716,,,DOID:13859|DOID:11395,SNOMEDCT_US_2016_03_01:26168007|UMLS_CUI:C0020192|OMIM:267450|MESH:D006819|ICD10CM:P22.0|SNOMEDCT_US_2016_03_01:46775006|SNOMEDCT_US_2016_03_01:206281003,pulmonary hyaline membrane disease|HMD - Hyaline membrane disease|pulmonary hypoperfusion syndrome of newborn|respiratory distress syndrome of newborn|Neonatal respiratory Distress syndrome|hyaline membrane disease,,disease_ontology,,DOID:12716,,,,,,,,,,,,,,,,,,,newborn respiratory distress syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12714,"[""Ellis-Van Creveld syndrome""]",,OMIM mapping confirmed by DO. [SN].,false,,,http://purl.obolibrary.org/obo/DOID_0050737,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12714,,,,OMIM:225500|ICD9CM:756.55|MESH:D004613|UMLS_CUI:C0013903|SNOMEDCT_US_2016_03_01:62501005|ICD10CM:Q77.6|NCI:C84684,Ellis-van Creveld syndrome|Chondroectodermal dysplasia|Chondroectodermal dysplasia (disorder),,disease_ontology,,DOID:12714,,,,,,,,,,,,,,,,,OMIM mapping confirmed by DO. [SN].,,Ellis-Van Creveld syndrome,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_12712,"[""nephronophthisis""]",,An autosomal recessive disease that is characterized by a chronic tubulointerstitial nephritis that progress to terminal renal failure during the second decade (juvenile form) or before the age of 5 years (infantile form) resulting from dysfunction of ciliary proteins (ciliopathy).,false,,,http://purl.obolibrary.org/obo/DOID_0050737,,,,,,,,An autosomal recessive disease that is characterized by a chronic tubulointerstitial nephritis that progress to terminal renal failure during the second decade (juvenile form) or before the age of 5 years (infantile form) resulting from dysfunction of ciliary proteins (ciliopathy).,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:12712,,,,OMIM:602088|ORDO:655|OMIM:613824|OMIM:614845|OMIM:616217|OMIM:611498|OMIM:614844|OMIM:613550|OMIM:613820|OMIM:256100|UMLS_CUI:C0687120|OMIM:615382|OMIM:615862|SNOMEDCT_US_2016_03_01:204958008|OMIM:614377|OMIM:613159|SNOMEDCT_US_2016_03_01:204961009|OMIM:606966|OMIM:604387|ICD10CM:Q61.5|NCI:C123200,medullary cystic kidney|medullary cystic disease,,disease_ontology,,DOID:12712,http://purl.obolibrary.org/obo/doid#DO_rare_slim,,,,,,,,,,,,,,,,"Xref MGI.
OMIM mapping confirmed by DO. [SN].",,nephronophthisis,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003478,"[""SNU-638 cell""]",,Human gastric cancer cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000787,,,,,,,,Human gastric cancer cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003478,,,,,,,BrendaTissueOBO,SNU638 cell,BTO:0003478,,,,,,,,,,,,,,,,,,,SNU-638 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300299,"[""NIM1 subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300116,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300299,,,,,,,,,,,,,,,,,,,,,,,,,,,,NIM1 subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200784,"[""TAS2R38 gene""]",,"A taste receptor type 2 member 38 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59533] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400014,,,,,,,,"A taste receptor type 2 member 38 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59533] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200784,,,,,,,,,,,,,,,,5726,TAS2R38,PTC,,,,,,,,,,TAS2R38 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200770,"[""SSTR1 gene""]",,"A somatostatin receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30872] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400002,,,,,,,,"A somatostatin receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30872] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200770,,,,,,,,,,,,,,,,6751,SSTR1,,,,,,,,,,,SSTR1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000178,"[""GRK4 kinase domain""]",,G protein-coupled receptor kinase 4; GPRK2L; GPRK4; GRK4; GRK4a; IT11,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,G protein-coupled receptor kinase 4; GPRK2L; GPRK4; GRK4; GRK4a; IT11,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000178,,,,,,,,,,,,,,,,,,,200181,,,,,,,,,GRK4 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100537,"[""Olfactory receptor 2l8""]",,"An olfactory receptor 2L8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY9] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 2L8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGY9] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100537,,,,https://pharos.nih.gov/idg/targets/Q8NGY9,,,,,,,,,,,,,OR2L8,,,Q8NGY9,,,,,,,,Olfactory receptor 2l8,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100257,"[""Ribosomal protein s6 kinase beta-1""]",,"A ribosomal protein S6 kinase beta-1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P23443] |ribosomal protein s6 kinase beta-1 (S6K1)  with  no mutation  in a nonphosphorylated state",false,,,http://www.drugtargetontology.org/dto/DTO_03300282,,,,,,,,"A ribosomal protein S6 kinase beta-1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P23443] |ribosomal protein s6 kinase beta-1 (S6K1)  with  no mutation  in a nonphosphorylated state",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100257,,,,https://pharos.nih.gov/idg/targets/P23443,,,,,,,,,,,,,RPS6KB1,STK14A,,P23443,,,,,,,,Ribosomal protein s6 kinase beta-1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002872,"[""embryonic hippocampal cell line""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002871|http://purl.obolibrary.org/obo/BTO_0003036,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002872,,,,,,,BrendaTissueOBO,,BTO:0002872,,,,,,,,,,,,,,,,,,,embryonic hippocampal cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200156,"[""FYN gene""]",,"This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400132,,,,,,,,"This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200156,,,,,,,,,,,,,,,,2534,FYN,,,,,,,,,,,FYN gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000099,"[""CSNK1D kinase domain""]",,"Casein kinase 1, delta; CK1d; CSNK1D; HCKID",false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,"Casein kinase 1, delta; CK1d; CSNK1D; HCKID",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000099,,,,,,,,,,,,,,,,,,,200098,,,,,,,,,CSNK1D kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80305,"[""Kisspeptin-14""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16091,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80305,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80305,,,,,Kisspeptin-14,,CHEBI:80305,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200213,"[""CSNK1G3 gene""]",,"This gene encodes a member of a family of serine/threonine protein kinases that phosphorylate caseins and other acidic proteins. A related protein in the African clawed frog participates in the transmission of Wnt/beta-catenin signaling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400170,,,,,,,,"This gene encodes a member of a family of serine/threonine protein kinases that phosphorylate caseins and other acidic proteins. A related protein in the African clawed frog participates in the transmission of Wnt/beta-catenin signaling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200213,,,,,,,,,,,,,,,,1456,CSNK1G3,,,,,,,,,,,CSNK1G3 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100753,"[""Platelet-activating factor receptor""]",,"A platelet-activating factor receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25105] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300002,,,,,,,,"A platelet-activating factor receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25105] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100753,,,,https://pharos.nih.gov/idg/targets/P25105,,,,,,,,,,,,,PTAFR,PAFR,,P25105,,,,,,,,Platelet-activating factor receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400163,"[""INSR family gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400163,,,,,,,,,,,,,,,,,,,,,,,,,,,,INSR family gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200731,"[""P2RY10 gene""]",,"A P2Y purinoceptor 10 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00398] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400100,,,,,,,,"A P2Y purinoceptor 10 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00398] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200731,,,,,,,,,,,,,,,,27334,P2RY10,,,,,,,,,,,P2RY10 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002715,"[""UM-SCC-38 cell""]",,Human neck squamous cell carcinoma cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0002709,,,,,,,,Human neck squamous cell carcinoma cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002715,,,,,,,BrendaTissueOBO,SCC-38 cell|SCC38 cell|UMSCC-38 cell|UMSCC38 cell,BTO:0002715,,,,,,,,,,,,,,,,,,,UM-SCC-38 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_1891,"[""optic nerve disease""]",,A cranial nerve disease that is located_in the optic nerve.,false,,,http://purl.obolibrary.org/obo/DOID_5656,,,,,,,,A cranial nerve disease that is located_in the optic nerve.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:1891,,,,SNOMEDCT_US_2016_03_01:77157004|SNOMEDCT_US_2016_03_01:267741008|MESH:D009901|UMLS_CUI:C0029132|NCI:C79698|SNOMEDCT_US_2016_03_01:194037001,optic neuropathy|optic nerve disorder|disorder of the second nerve,,disease_ontology,,DOID:1891,,,,,,,,,,,,,,,,,,,optic nerve disease,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200468,"[""POMK gene""]",,"This gene encodes a protein that may be involved in the presentation of the laminin-binding O-linked carbohydrate chain of alpha-dystroglycan (a-DG), which forms transmembrane linkages between the extracellular matrix and the exoskeleton. Some pathogens use this O-linked carbohydrate unit for host entry. Loss of function compound heterozygous mutations in this gene were found in a human patient affected by the Walker-Warburg syndrome (WWS) phenotype. Mice lacking this gene contain misplaced neurons (heterotopia) in some regions of the brain, possibly from defects in neuronal migration. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400218,,,,,,,,"This gene encodes a protein that may be involved in the presentation of the laminin-binding O-linked carbohydrate chain of alpha-dystroglycan (a-DG), which forms transmembrane linkages between the extracellular matrix and the exoskeleton. Some pathogens use this O-linked carbohydrate unit for host entry. Loss of function compound heterozygous mutations in this gene were found in a human patient affected by the Walker-Warburg syndrome (WWS) phenotype. Mice lacking this gene contain misplaced neurons (heterotopia) in some regions of the brain, possibly from defects in neuronal migration. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200468,,,,,,,,,,,,,,,,84197,POMK,SGK196,,,,,,,,,,POMK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03100056,"[""Cell division cycle 7-related protein kinase""]",,"A cell division cycle 7-related protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00311] ",false,,,http://www.drugtargetontology.org/dto/DTO_03300137,,,,,,,,"A cell division cycle 7-related protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00311] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03100056,,,,https://pharos.nih.gov/idg/targets/O00311,,,,,,,,,,,,,CDC7,CDC7L1,,O00311,,,,,,,,Cell division cycle 7-related protein kinase,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200155,"[""FRK gene""]",,"The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]",false,,,http://www.drugtargetontology.org/dto/DTO_03400132,,,,,,,,"The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200155,,,,,,,,,,,,,,,,2444,FRK,PTK5|RAK,,,,,,,,,,FRK gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000226,"[""KPCD2 kinase domain""]",,Protein kinase D2; HSPC187; PKD2; PRKD2,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Protein kinase D2; HSPC187; PKD2; PRKD2,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000226,,,,,,,,,,,,,,,,,,,200360,,,,,,,,,KPCD2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400266,"[""Dyrk1 subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400150,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400266,,,,,,,,,,,,,,,,,,,,,,,,,,,,Dyrk1 subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200736,"[""ADCYAP1R1 gene""]",,"A pituitary adenylate cyclase-activating polypeptide type I receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41586] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400003,,,,,,,,"A pituitary adenylate cyclase-activating polypeptide type I receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41586] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200736,,,,,,,,,,,,,,,,117,ADCYAP1R1,,,,,,,,,,,ADCYAP1R1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100755,"[""Parathyroid hormone 2 receptor""]",,"A parathyroid hormone 2 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49190] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300084,,,,,,,,"A parathyroid hormone 2 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49190] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100755,,,,https://pharos.nih.gov/idg/targets/P49190,,,,,,,,,,,,,PTH2R,PTHR2,,P49190,,,,,,,,Parathyroid hormone 2 receptor,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000382,"[""RIOK3 kinase domain""]",,RIO kinase 3 (yeast); DKFZp779L1370; RIOK3; SUDD,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,RIO kinase 3 (yeast); DKFZp779L1370; RIOK3; SUDD,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000382,,,,,,,,,,,,,,,,,,,200376,,,,,,,,,RIOK3 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217538,"[""NR1D1 gene""]",,"This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_00217463,,,,,,,,"This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217538,,,,,,,,,,,,,,,,9572,NR1D1,EAR1|HREV|THRAL,,,,,,,,,,NR1D1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100136,"[""Glutamate receptor 4""]",,"A glutamate receptor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48058] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300413,,,,,,,,"A glutamate receptor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48058] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100136,,,,https://pharos.nih.gov/idg/targets/P48058,,,,,,,,,,,,,GRIA4,GLUR4,,P48058,,,,,,,,Glutamate receptor 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0001345,"[""T-24 cell""]",,"Human urinary bladder carcinoma, established from the primary tumor of an 81-year-old Caucasian woman with urinary bladder carcinoma (transitional cell carcinoma, grade III) in 1970; described to produce a variety of cytokines (e.g. G-CSF, IL-6 and SCF) and to carry a p53 mutation.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000792,,,,,,,,"Human urinary bladder carcinoma, established from the primary tumor of an 81-year-old Caucasian woman with urinary bladder carcinoma (transitional cell carcinoma, grade III) in 1970; described to produce a variety of cytokines (e.g. G-CSF, IL-6 and SCF) and to carry a p53 mutation.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0001345,,,,,,,BrendaTissueOBO,T24 cell,BTO:0001345,,,,,,,,,,,,,,,,,,,T-24 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2848,"[""melancholia""]",,,false,,,http://purl.obolibrary.org/obo/DOID_1596,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2848,,,,UMLS_CUI:C0025193|NCI:C34812|SNOMEDCT_US_2016_03_01:35489007|MESH:D003866,,,disease_ontology,,DOID:2848,,,,,,,,,,,,,,,,,,,melancholia,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004608,"[""Henles loop""]",,"The long U-shaped part of the renal tubule, extending through the medulla from the end of the proximal convoluted tubule. It begins with a descending limb comprising the proximal straight tubule and the thin tubule, followed by the ascending limb the distal straight tubule, and ending at the distal convoluted tubule.",false,,,http://www.drugtargetontology.org/dto/DTO_00000018,,,,,,,,"The long U-shaped part of the renal tubule, extending through the medulla from the end of the proximal convoluted tubule. It begins with a descending limb comprising the proximal straight tubule and the thin tubule, followed by the ascending limb the distal straight tubule, and ending at the distal convoluted tubule.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004608,mgr,2010-04-13T11:09:09Z,,,,,BrendaTissueOBO,loop of Henle,BTO:0004608,,,,,,,,,,,,,,,,,,,Henles loop,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300346,"[""Phagocyte (gp91(phox)) nadph oxidase family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300346,,,,,,,,,,,,,,,,,,,,,,,,,,,,Phagocyte (gp91(phox)) nadph oxidase family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000088,"[""CHK2 kinase domain""]",,Serine/threonine-protein kinase Chk2; CHK2 checkpoint homolog,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Serine/threonine-protein kinase Chk2; CHK2 checkpoint homolog,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000088,,,,,,,,,,,,,,,,,,,200088,,,,,,,,,CHK2 kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01100329,"[""Transient receptor potential cation channel subfamily M member 4""]",,"A transient receptor potential cation channel subfamily M member 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TD43] ",false,,,http://www.drugtargetontology.org/dto/DTO_01300586,,,,,,,,"A transient receptor potential cation channel subfamily M member 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TD43] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01100329,,,,https://pharos.nih.gov/idg/targets/Q8TD43,,,,,,,,,,,,,TRPM4,LTRPC4,,Q8TD43,,,,,,,,Transient receptor potential cation channel subfamily M member 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004502,"[""vascular cambium""]",,Cambium that produces secondary phloem on its outer side and secondary xylem on its inner side.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000170,,,,,,,,Cambium that produces secondary phloem on its outer side and secondary xylem on its inner side.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004502,Marion,2010-02-08T12:48:00Z,,,,,BrendaTissueOBO,,BTO:0004502,,,,,,,,,,,,,,,,,,,vascular cambium,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03300137,"[""CDC7 family""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03300104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03300137,,,,,,,,,,,,,,,,,,,,,,,,,,,,CDC7 family,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01200154,"[""KCNJ15 gene""]",,"Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_01400426,,,,,,,,"Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01200154,,,,,,,,,,,,,,,,3772,KCNJ15,KCNJ14,,,,,,,,,,KCNJ15 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0003147,"[""juvenile leaf""]",,"Distinct from adult leaves, being characterized by particular anatomical traits namely, wax and trichome distribution, presence or absence of epidermal cell types, cell wall shape and biochemistry. The first juvenile leaves are e.g. the embryonic leaves found in the grass kernel (caryopsis).",false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000713,,,,,,,,"Distinct from adult leaves, being characterized by particular anatomical traits namely, wax and trichome distribution, presence or absence of epidermal cell types, cell wall shape and biochemistry. The first juvenile leaves are e.g. the embryonic leaves found in the grass kernel (caryopsis).",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0003147,,,,,,,BrendaTissueOBO,,BTO:0003147,,,,,,,,,,,,,,,,,,,juvenile leaf,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100294,"[""Olfactory receptor 10AC1""]",,"An olfactory receptor 10AC1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH08] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300013,,,,,,,,"An olfactory receptor 10AC1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NH08] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100294,,,,https://pharos.nih.gov/idg/targets/Q8NH08,,,,,,,,,,,,,OR10AC1,OR10AC1P,,Q8NH08,,,,,,,,Olfactory receptor 10AC1,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_9415,"[""allergic asthma""]",,"An asthma that is characterized by symptoms that are triggered by an allergic reaction caused by inhaled allergens such as dust mite allergen, pet dander, pollen and mold. Allergic asthma is airway obstruction and inflammation that is partially reversible with medication. The disease has_symptom coughing, has_symptom wheezing, has_symptom shortness of breath or has_symptom rapid breathing, and has_symptom chest tightness.",false,,,http://purl.obolibrary.org/obo/DOID_2841,,,,,,,,"An asthma that is characterized by symptoms that are triggered by an allergic reaction caused by inhaled allergens such as dust mite allergen, pet dander, pollen and mold. Allergic asthma is airway obstruction and inflammation that is partially reversible with medication. The disease has_symptom coughing, has_symptom wheezing, has_symptom shortness of breath or has_symptom rapid breathing, and has_symptom chest tightness.",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:9415,,,DOID:9416|DOID:9417,SNOMEDCT_US_2016_03_01:195972005|ICD10CM:J45|SNOMEDCT_US_2016_03_01:266358007|SNOMEDCT_US_2016_03_01:266396008|SNOMEDCT_US_2016_03_01:233680000|SNOMEDCT_US_2016_03_01:389146007|SNOMEDCT_US_2016_03_01:195968006|ICD9CM:493.0|SNOMEDCT_US_2016_03_01:389145006|UMLS_CUI:C0155877|SNOMEDCT_US_2016_03_01:16862005|SNOMEDCT_US_2016_03_01:155575009,extrinsic asthma with acute exacerbation|extrinsic asthma with status asthmaticus,,disease_ontology,atopic asthma,DOID:9415,,,,,,,,,,,,,,,,,,,allergic asthma,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_01300521,"[""GABRR1 sub-subfamily""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_01300408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_01300521,,,,,,,,,,,,,,,,,,,,,,,,,,,,GABRR1 sub-subfamily,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200344,"[""OR13C8 gene""]",,"An olfactory receptor 13C8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS7] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 13C8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NGS7] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200344,,,,,,,,,,,,,,,,138802,OR13C8,,,,,,,,,,,OR13C8 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0004467,"[""LbetaT2 cell""]",,Murine pituitary gonadotrope cell line.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000427,,,,,,,,Murine pituitary gonadotrope cell line.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0004467,Marion,2010-02-04T09:45:37Z,,,,,BrendaTissueOBO,,BTO:0004467,,,,,,,,,,,,,,,,,,,LbetaT2 cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_00217459,"[""Dax-like receptors gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00200002,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_00217459,,,,,,,,,,,,,,,,,,,,,,,,,,,,Dax-like receptors gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_2696,"[""Leydig cell tumor""]",,,false,,,http://purl.obolibrary.org/obo/DOID_4757,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:2696,,,,SNOMEDCT_US_2016_03_01:45002009|SNOMEDCT_US_2016_03_01:189739005|NCI:C3188|UMLS_CUI:C0023601|MESH:D007984,Leydig cell neoplasm,,disease_ontology,,DOID:2696,,,,,,,,,,,,,,,,,,,Leydig cell tumor,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02100283,"[""Neuropeptide Y receptor type 4""]",,"A neuropeptide Y receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P50391] ",false,,,http://www.drugtargetontology.org/dto/DTO_02300071,,,,,,,,"A neuropeptide Y receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P50391] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02100283,,,,https://pharos.nih.gov/idg/targets/P50391,,,,,,,,,,,,,NPY4R,PPYR1,,P50391,,,,,,,,Neuropeptide Y receptor type 4,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200642,"[""OR5P2 gene""]",,"An olfactory receptor 5P2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZ92] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 5P2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZ92] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200642,,,,,,,,,,,,,,,,120065,OR5P2,,,,,,,,,,,OR5P2 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_61000371,"[""PRKR kinase domain""]",,Eukaryotic translation initiation factor 2-alpha kinase 2; EIF2AK1; EIF2AK2; MGC126524; PKR; PRKR,false,,,http://www.drugtargetontology.org/dto/DTO_61000000,,,,,,,,Eukaryotic translation initiation factor 2-alpha kinase 2; EIF2AK1; EIF2AK2; MGC126524; PKR; PRKR,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_61000371,,,,,,,,,,,,,,,,,,,200364,,,,,,,,,PRKR kinase domain,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002628,"[""B-lymphoblastoma cell""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000774,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002628,,,,,,,BrendaTissueOBO,,BTO:0002628,,,,,,,,,,,,,,,,,,,B-lymphoblastoma cell,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03400305,"[""PASK subfamily gene""]",,,false,,,http://www.drugtargetontology.org/dto/DTO_03400116,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03400305,,,,,,,,,,,,,,,,,,,,,,,,,,,,PASK subfamily gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/BTO_0002406,"[""eosinophilic leukemia cell line""]",,A form of granulocytic leukemia cell line characterized by abnormal numbers of or a predomination of eosinophilic granulocytes in the tissues and blood.,false,,,http://www.drugtargetontology.org/dto/DTO_00000018|http://purl.obolibrary.org/obo/BTO_0000737,,,,,,,,A form of granulocytic leukemia cell line characterized by abnormal numbers of or a predomination of eosinophilic granulocytes in the tissues and blood.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,BTO:0002406,,,,,,,BrendaTissueOBO,,BTO:0002406,,,,,,,,,,,,,,,,,,,eosinophilic leukemia cell line,,,,http://purl.obolibrary.org/obo/bto.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200499,"[""STK25 gene""]",,"This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]",false,,,http://www.drugtargetontology.org/dto/DTO_03400297,,,,,,,,"This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200499,,,,,,,,,,,,,,,,10494,STK25,SOK1|YSK1,,,,,,,,,,STK25 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_62000099,"[""MET1059 in INSRR""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16044,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,http://www.drugtargetontology.org/dto/DTO_00000002,,,,,,,,,,,dto:DTO_62000099,,,,,,,,,,,,,,,,,,,,,,,,,,,,MET1059 in INSRR,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/DOID_3953,"[""adrenal gland cancer""]",,An endocrine gland cancer located_in the adrenal glands which are located above the kidneys.,false,,,http://purl.obolibrary.org/obo/DOID_170|http://purl.obolibrary.org/obo/DOID_9553,,,,,,,,An endocrine gland cancer located_in the adrenal glands which are located above the kidneys.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,DOID:3953,,,DOID:11007,UMLS_CUI:C0001624|ICD10CM:C74.9|SNOMEDCT_US_2016_03_01:188338005|NCI:C2859|MESH:D000310|UMLS_CUI:C0750887|SNOMEDCT_US_2016_03_01:93665005|SNOMEDCT_US_2016_03_01:188337000|ICD9CM:194.0|ICD10CM:C74|SNOMEDCT_US_2016_03_01:127021009|SNOMEDCT_US_2016_03_01:363355002|NCI:C9338,adrenal neoplasm|malignant Adrenal tumor|tumor of the Adrenal gland|adrenal cancer|neoplasm of adrenal gland (disorder)|malignant neoplasm of adrenal gland,,disease_ontology,,DOID:3953,http://purl.obolibrary.org/obo/doid#TopNodes_DOcancerslim,,,,,,,,,,,,,,,,,,adrenal gland cancer,,,,http://purl.obolibrary.org/obo/doid.owl,,,,,,,,,,,,,,,,,,,,,,,,,
http://purl.obolibrary.org/obo/CHEBI_80330,"[""Peptide YY""]",,,false,,,http://purl.obolibrary.org/obo/CHEBI_16670,,,,,,,KEGG:C16118,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,chebi_ontology,,,,CHEBI:80330,,,,,,,,,,,,,,,,,,,,,,,CHEBI:80330,,,,,Peptide YY,,CHEBI:80330,,http://purl.obolibrary.org/obo/chebi.owl,http://purl.oboInOwllibrary.org/oboInOwl/chebi#2_STAR,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_02200335,"[""OR11H12 gene""]",,"An olfactory receptor 11H12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:B2RN74] ",false,,,http://www.drugtargetontology.org/dto/DTO_02400013,,,,,,,,"An olfactory receptor 11H12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:B2RN74] ",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_02200335,,,,,,,,,,,,,,,,440153,OR11H12,,,,,,,,,,,OR11H12 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
http://www.drugtargetontology.org/dto/DTO_03200098,"[""DAPK1 gene""]",,"Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]",false,,,http://www.drugtargetontology.org/dto/DTO_03400146,,,,,,,,"Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,dto:DTO_03200098,,,,,,,,,,,,,,,,1612,DAPK1,DAPK,,,,,,,,,,DAPK1 gene,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
